Jiake Xu - University of Western Australia - Professor

Jiake Xu

University of Western Australia

Professor

Perth, Western Australia | Australia

Main Specialties: Pathology-Anatomic & Clinical

Additional Specialties: Pathology

Jiake Xu - University of Western Australia - Professor

Jiake Xu

Introduction

Primary Affiliation: University of Western Australia - Perth, Western Australia , Australia

Specialties:

Additional Specialties:

Publications

80Publications

1656Reads

903Profile Views

972PubMed Central Citations

Anti-catabolic effect of caffeic acid phenethyl ester, an active component of honeybee propolis on bone loss in ovariectomized mice: a micro-computed tomography study and histological analysis.

Chin Med J (Engl) 2014 ;127(22):3932-6

Department of Orthopaedics, the Second Hospital of Shanxi Medical University, Shanxi Key Lab of Bone and Soft Tissue Injury Repair, Taiyuan, Shanxi 030001, China. Email:

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August 2015
11 Reads
1 Citation
1.020 Impact Factor

Protein kinase C inhibitor, GF109203X attenuates osteoclastogenesis, bone resorption and RANKL-induced NF-κB and NFAT activity.

J Cell Physiol 2015 Jun;230(6):1235-42

Department of Orthopaedic Surgery, Research Centre for Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, Guangxi, China; School of Pathology and Laboratory Medicine, The University of Western Australia, Perth, Western Australia, Australia.

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http://dx.doi.org/10.1002/jcp.24858DOI Listing
June 2015
28 Reads
2 Citations
3.840 Impact Factor

Non-severe burn injury leads to depletion of bone volume that can be ameliorated by inhibiting TNF-α.

Burns 2015 May 8;41(3):558-64. Epub 2014 Oct 8.

Burn Injury Research Unit, School of Surgery, University of Western Australia, Perth, Australia; The Fiona Wood Foundation, Royal Perth Hospital, Perth, Australia; School of Medicine, University of Notre Dame Australia, Fremantle, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.burns.2014.09.004DOI Listing
May 2015
9 Reads
8 Citations
1.840 Impact Factor

Epidermal stem cells cultured on collagen-modified chitin membrane induce in situ tissue regeneration of full-thickness skin defects in mice.

PLoS One 2014 7;9(2):e87557. Epub 2014 Feb 7.

Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital Medical College, Jinan University, Guangzhou, People's Republic of China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087557PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917838PMC
May 2015
26 Reads
3 Citations
3.234 Impact Factor

Macrophage migration inhibitory factor is essential for osteoclastogenic mechanisms in vitro and in vivo mouse model of arthritis.

Cytokine 2015 Apr 31;72(2):135-45. Epub 2015 Jan 31.

Centre for Inflammatory Disease, Monash University, Clayton, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2014.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355090PMC
April 2015
33 Reads
7 Citations
2.664 Impact Factor

Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy.

Nat Med 2015 Mar 9;21(3):288-94. Epub 2015 Feb 9.

1] Institute for Advancing Translational Medicine in Bone &Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. [2] Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China. [3] Academician Chen Xinzi Workroom for Advancing Translational Medicine in Bone &Joint Diseases, Kunshan RNAi Institute, Kunshan Industrial Technology Research Institute, Kunshan, Jiangsu, China. [4] Institute of Integrated Bioinfomedicine &Translational Science, Hong Kong Baptist University Shenzhen Research Institute and Continuing Education, Shenzhen, China. [5] Shum Yiu Foon Shum Bik Chuen Memorial Centre for Cancer and Inflammation Research, Hong Kong Baptist University Shenzhen Research Institute and Continuing Education, Shenzhen, China. [6] Hong Kong Baptist University Branch of State Key Laboratory of Chemo/Biosensing and Chemometrics of Hunan University, Hong Kong, China. [7] Hong Kong Baptist University-Northwestern Polytechnical University Joint Research Centre for Translational Medicine on Musculoskeletal Health in Space, Shenzhen, China. [8] Key Laboratory for Space Bioscience and Biotechnology, Institute of Special Environmental Biophysics, School of Life Science, Northwestern Polytechnical University, Xi'an, China. [9] Institute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Shanghai, China.

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http://dx.doi.org/10.1038/nm.3791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508976PMC
March 2015
80 Reads
40 Citations
27.363 Impact Factor

An effective and practical immunohistochemical protocol for bone specimens characterized by hyaluronidase and pepsin predigestion combined with alkaline phosphatase-mediated chromogenic detection.

Histol Histopathol 2015 Mar 29;30(3):331-43. Epub 2014 Sep 29.

Department of Spine Surgery, the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou Guangdong, P.R.China.

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http://dx.doi.org/10.14670/HH-30.331DOI Listing
March 2015
18 Reads
2.100 Impact Factor

Construction and biomechanical properties of polyaxial self-locking anatomical plate based on the geometry of distal tibia.

Biomed Res Int 2014 16;2014:436325. Epub 2014 Jun 16.

Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou 510220, China ; School of Pathology and Laboratory Medicine, The University of Western Australia, Crawley, WA 6009, Australia.

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http://dx.doi.org/10.1155/2014/436325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082832PMC
March 2015
33 Reads

microRNA-103a functions as a mechanosensitive microRNA to inhibit bone formation through targeting Runx2.

J Bone Miner Res 2015 Feb;30(2):330-45

Department of Orthopedic Surgery, Xinhua Hospital, Shanghai JiaoTong University School of Medicine (SJTUSM), Shanghai, China.

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http://dx.doi.org/10.1002/jbmr.2352DOI Listing
February 2015
39 Reads
30 Citations
6.832 Impact Factor

EGFL7 is expressed in bone microenvironment and promotes angiogenesis via ERK, STAT3, and integrin signaling cascades.

J Cell Physiol 2015 Jan;230(1):82-94

School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, WA, Australia.

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http://dx.doi.org/10.1002/jcp.24684DOI Listing
January 2015
80 Reads
4 Citations
3.840 Impact Factor

Triptolide inhibits osteoclast formation, bone resorption, RANKL-mediated NF-қB activation and titanium particle-induced osteolysis in a mouse model.

Mol Cell Endocrinol 2015 Jan 3;399:346-53. Epub 2014 Nov 3.

Orthopaedic Department, Memorial Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2014.10.016DOI Listing
January 2015
22 Reads
8 Citations
4.410 Impact Factor

Differential expression of extracellular-signal-regulated kinase 5 (ERK5) in normal and degenerated human nucleus pulposus tissues and cells.

Biochem Biophys Res Commun 2014 Jul 21;449(4):466-70. Epub 2014 May 21.

Guangzhou Institute of Traumatic Surgery, The Fourth Affiliated Hospital of Medical College, Jinan University, Guangzhou 510220, China; School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia 6009, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.05.042DOI Listing
July 2014
14 Reads
3 Citations
2.300 Impact Factor

Microstructural and compositional features of the fibrous and hyaline cartilage on the medial tibial plateau imply a unique role for the hopping locomotion of kangaroo.

PLoS One 2013 18;8(9):e74303. Epub 2013 Sep 18.

School of Pathology and Laboratory Medicine, The University of Western Australia, Crawley, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074303PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776843PMC
June 2014
15 Reads
3 Citations
3.234 Impact Factor

CHIP/Stub1 functions as a tumor suppressor and represses NF-κB-mediated signaling in colorectal cancer.

Carcinogenesis 2014 May 3;35(5):983-91. Epub 2013 Dec 3.

State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Medicine, National Engineering Laboratory for Anti-tumor Therapeutics, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1093/carcin/bgt393DOI Listing
May 2014
16 Reads
22 Citations
5.334 Impact Factor

A conceptual framework for computational models of Achilles tendon homeostasis.

Wiley Interdiscip Rev Syst Biol Med 2013 Sep-Oct;5(5):523-38. Epub 2013 Jun 11.

Faculty of Engineering, Computing, and Mathematics, The University of Western Australia, Crawley, Western Australia, Australia.

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http://dx.doi.org/10.1002/wsbm.1229DOI Listing
March 2014
8 Reads
5 Citations

New bone formation and microstructure assessed by combination of confocal laser scanning microscopy and differential interference contrast microscopy.

Calcif Tissue Int 2014 Mar 20;94(3):338-47. Epub 2013 Nov 20.

Guangzhou Institute of Traumatic Surgery, The Fourth Affiliated Hospital, Jinan University School of Medicine, 396 Tong Fu Zhonglu Road, Hai Zhu District, Guangzhou, 510220, Guangdong, People's Republic of China,

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http://dx.doi.org/10.1007/s00223-013-9815-6DOI Listing
March 2014
28 Reads
4 Citations
3.272 Impact Factor

The role of SATB2 in skeletogenesis and human disease.

Cytokine Growth Factor Rev 2014 Feb 25;25(1):35-44. Epub 2013 Dec 25.

The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine (SJTUSM) & Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai 200025, China; Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China. Electronic address:

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http://dx.doi.org/10.1016/j.cytogfr.2013.12.010DOI Listing
February 2014
11 Reads
14 Citations
5.360 Impact Factor

Electrochemical behavior of (Ti 1-x Nb x)5Si3 nanocrystalline films in simulated physiological media.

Acta Biomater 2014 Feb 27;10(2):1005-13. Epub 2013 Sep 27.

School of Mechanical Engineering, University of Adelaide, Adelaide, SA 5005, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2013.09.021DOI Listing
February 2014
59 Reads
1 Citation
6.030 Impact Factor

HtrA1 is upregulated during RANKL-induced osteoclastogenesis, and negatively regulates osteoblast differentiation and BMP2-induced Smad1/5/8, ERK and p38 phosphorylation.

FEBS Lett 2014 Jan 21;588(1):143-50. Epub 2013 Nov 21.

School of Pathology and Laboratory Medicine, University of Western Australia, Perth, WA 6009, Australia; Research Centre for Regenerative Medicine, Department of Orthopaedic Surgery, The First Affiliated Hospital of Guangxi Medical University, Guangxi 530021, China. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2013.11.022DOI Listing
January 2014
8 Reads
5 Citations
3.170 Impact Factor

SC-514, a selective inhibitor of IKKβ attenuates RANKL-induced osteoclastogenesis and NF-κB activation.

Biochem Pharmacol 2013 Dec 30;86(12):1775-83. Epub 2013 Sep 30.

Department of Orthopaedic Surgery, The First Affiliated Hospital of Guangxi Medical University, Guangxi 530021, China; School of Pathology and Laboratory Medicine, The University of Western Australia, Crawley 6009, Western Australia, Australia; Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, Crawley 6009, Western Australia, Australia.

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http://dx.doi.org/10.1016/j.bcp.2013.09.017DOI Listing
December 2013
10 Reads
7 Citations
5.010 Impact Factor

Elastin fibers display a versatile microfibril network in articular cartilage depending on the mechanical microenvironments.

J Orthop Res 2013 Sep 3;31(9):1345-53. Epub 2013 May 3.

School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, 6009, Australia.

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http://dx.doi.org/10.1002/jor.22384DOI Listing
September 2013
16 Reads
4 Citations
2.990 Impact Factor

New insights into the role of sequestosome 1/p62 mutant proteins in the pathogenesis of Paget's disease of bone.

Endocr Rev 2013 Aug 23;34(4):501-24. Epub 2013 Apr 23.

Department of Endocrinology and Diabetes, Level 1, C Block, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, Western Australia 6009, Australia.

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http://dx.doi.org/10.1210/er.2012-1034DOI Listing
August 2013
42 Reads
17 Citations
21.060 Impact Factor

Angiogenic factors in bone local environment.

Cytokine Growth Factor Rev 2013 Jun 20;24(3):297-310. Epub 2013 Apr 20.

Molecular Lab, School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, WA 6009, Australia.

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http://dx.doi.org/10.1016/j.cytogfr.2013.03.008DOI Listing
June 2013
4 Reads
29 Citations
5.360 Impact Factor

Bioreactor design for tendon/ligament engineering.

Tissue Eng Part B Rev 2013 Apr 19;19(2):133-46. Epub 2012 Nov 19.

Centre for Orthopaedic Translational Research, School of Surgery, University of Western Australia, Crawley, Australia.

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http://dx.doi.org/10.1089/ten.TEB.2012.0295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589869PMC
April 2013
6 Reads
8 Citations

HSP90 inhibitors enhance differentiation and MITF (microphthalmia transcription factor) activity in osteoclast progenitors.

Biochem J 2013 Apr;451(2):235-44

Prince Henry's Institute, Monash Medical Centre, Clayton, VIC 3168, Australia.

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http://dx.doi.org/10.1042/BJ20121626DOI Listing
April 2013
17 Reads
7 Citations
4.400 Impact Factor

Disruption of the dynein-dynactin complex unveils motor-specific functions in osteoclast formation and bone resorption.

J Bone Miner Res 2013 Jan;28(1):119-34

Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, Nedlands, WA, Australia.

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http://dx.doi.org/10.1002/jbmr.1725DOI Listing
January 2013
12 Reads
12 Citations
6.832 Impact Factor

Prevention of wear particle-induced osteolysis by a novel V-ATPase inhibitor saliphenylhalamide through inhibition of osteoclast bone resorption.

PLoS One 2012 11;7(4):e34132. Epub 2012 Apr 11.

Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, The People's Republic of China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034132PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324493PMC
August 2012
26 Reads
13 Citations
3.234 Impact Factor

Introduction: Understanding the signalling mechanisms in molecular physiology and diseases.

Clin Exp Pharmacol Physiol 2012 Aug;39(8):658-60

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http://dx.doi.org/10.1111/j.1440-1681.2012.05740.xDOI Listing
August 2012
9 Reads

An overview of the regulation of bone remodelling at the cellular level.

Clin Biochem 2012 Aug 23;45(12):863-73. Epub 2012 Mar 23.

School of Pathology and Laboratory Medicine, The University of Western Australia, Western Australia, Australia.

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http://dx.doi.org/10.1016/j.clinbiochem.2012.03.021DOI Listing
August 2012
20 Reads
56 Citations
2.230 Impact Factor

miR-764-5p promotes osteoblast differentiation through inhibition of CHIP/STUB1 expression.

J Bone Miner Res 2012 Jul;27(7):1607-18

State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Medicine, Tsinghua University, Beijing, China.

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http://dx.doi.org/10.1002/jbmr.1597DOI Listing
July 2012
12 Reads
16 Citations
6.832 Impact Factor

Methotrexate chemotherapy promotes osteoclast formation in the long bone of rats via increased pro-inflammatory cytokines and enhanced NF-κB activation.

Am J Pathol 2012 Jul 27;181(1):121-9. Epub 2012 May 27.

Sansom Institute and the School of Pharmacy and Medical Science, the University of South Australia, Adelaide, Australia.

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http://dx.doi.org/10.1016/j.ajpath.2012.03.037DOI Listing
July 2012
17 Reads
11 Citations
4.591 Impact Factor

Overexpression of hTERT extends replicative capacity of human nucleus pulposus cells, and protects against serum starvation-induced apoptosis and cell cycle arrest.

J Cell Biochem 2012 Jun;113(6):2112-21

Guangzhou Institute of Traumatic Surgery, the Fourth Affiliated Hospital of Medical College, Jinan University, Guangzhou 510220, China.

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http://dx.doi.org/10.1002/jcb.24082DOI Listing
June 2012
4 Reads
5 Citations
3.263 Impact Factor

Receptor activator of NF-κB ligand promotes proliferation of a putative mammary stem cell unique to the lactating epithelium.

Stem Cells 2012 Jun;30(6):1255-64

School of Biomedical, Biomolecular and Chemical Sciences, Subiaco, Western Australia, Australia.

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http://dx.doi.org/10.1002/stem.1092DOI Listing
June 2012
20 Reads
6 Citations
6.523 Impact Factor

Versatile roles of V-ATPases accessory subunit Ac45 in osteoclast formation and function.

PLoS One 2011 4;6(11):e27155. Epub 2011 Nov 4.

Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedics, Shanghai Jiao Tong University School of Medicine, Ninth People's Hospital, Shanghai, The People's Republic of China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027155PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210823PMC
May 2012
15 Reads
11 Citations
3.234 Impact Factor

Membrane-bound receptor activator of NFκB ligand (RANKL) activity displayed by osteoblasts is differentially regulated by osteolytic factors.

Biochem Biophys Res Commun 2012 May 27;422(1):48-53. Epub 2012 Apr 27.

Prince Henry's Institute, Clayton, Australia.

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http://dx.doi.org/10.1016/j.bbrc.2012.04.103DOI Listing
May 2012
27 Reads
7 Citations
2.300 Impact Factor

Paclitaxel inhibits osteoclast formation and bone resorption via influencing mitotic cell cycle arrest and RANKL-induced activation of NF-κB and ERK.

J Cell Biochem 2012 Mar;113(3):946-55

School of Dentistry, University of Western Australia, Nedlands, WA 6009, Australia.

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http://dx.doi.org/10.1002/jcb.23423DOI Listing
March 2012
7 Reads
5 Citations
3.263 Impact Factor

In vitro evaluation of natural marine sponge collagen as a scaffold for bone tissue engineering.

Int J Biol Sci 2011 7;7(7):968-77. Epub 2011 Aug 7.

Division of Orthopaedic Surgery, Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangzhou, Guangdong 510080, P.R. China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157271PMC
January 2012
9 Reads
6 Citations
4.510 Impact Factor

Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-κB and ERK activation.

FEBS Lett 2011 Sep 6;585(17):2755-62. Epub 2011 Aug 6.

School of Dentistry, Oral Biology Research Laboratory, The University of Western Australia, Nedlands, WA 6009, Australia.

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http://dx.doi.org/10.1016/j.febslet.2011.07.046DOI Listing
September 2011
15 Reads
15 Citations
3.170 Impact Factor

Autologous tenocyte therapy for experimental Achilles tendinopathy in a rabbit model.

Tissue Eng Part A 2011 Aug 10;17(15-16):2037-48. Epub 2011 Jun 10.

Centre for Orthopaedic Research, School of Surgery, University of Western Australia, Nedlands, Western Australia, Australia.

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http://dx.doi.org/10.1089/ten.TEA.2010.0492DOI Listing
August 2011
5 Reads
20 Citations

In situ accumulation of advanced glycation endproducts (AGEs) in bone matrix and its correlation with osteoclastic bone resorption.

Bone 2011 Aug 21;49(2):174-83. Epub 2011 Apr 21.

Department of Health and Kinesiology, The University of Texas at Tyler, Tyler, TX 75799, USA.

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http://dx.doi.org/10.1016/j.bone.2011.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117937PMC
August 2011
10 Reads
14 Citations

EGFL6 promotes endothelial cell migration and angiogenesis through the activation of extracellular signal-regulated kinase.

J Biol Chem 2011 Jun 29;286(25):22035-46. Epub 2011 Apr 29.

School of Pathology and Laboratory Medicine, The Universityof Western Australia, Western Australia 6009, Australia

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http://dx.doi.org/10.1074/jbc.M110.187633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121348PMC
June 2011
56 Reads
22 Citations
4.573 Impact Factor

Tctex-1, a novel interaction partner of Rab3D, is required for osteoclastic bone resorption.

Mol Cell Biol 2011 Apr 24;31(7):1551-64. Epub 2011 Jan 24.

Centre for Orthopaedic Research, School of Surgery, University of Western Australia, Perth 6009, Western Australia, Australia.

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http://dx.doi.org/10.1128/MCB.00834-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135285PMC
April 2011
13 Reads
9 Citations
4.780 Impact Factor

Cellular response and extracellular matrix breakdown in rotator cuff tendon rupture.

Arch Orthop Trauma Surg 2011 Mar 6;131(3):405-11. Epub 2010 Aug 6.

Centre for Orthopaedic Research, School of Surgery, University of Western Australia, M Block, QE2 Medical Centre, Nedlands, Perth, WA, 6009, Australia.

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http://dx.doi.org/10.1007/s00402-010-1157-5DOI Listing
March 2011
17 Reads
7 Citations
1.310 Impact Factor

Mangiferin attenuates osteoclastogenesis, bone resorption, and RANKL-induced activation of NF-κB and ERK.

J Cell Biochem 2011 Jan;112(1):89-97

School of Surgery, The University of Western Australia, Nedlands, Western Australia 6009, Australia.

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http://dx.doi.org/10.1002/jcb.22800DOI Listing
January 2011
13 Reads
19 Citations
3.263 Impact Factor

In chronic lateral epicondylitis, apoptosis and autophagic cell death occur in the extensor carpi radialis brevis tendon.

J Shoulder Elbow Surg 2010 Apr;19(3):355-62

Unit of Orthopaedic Research, School of Surgery, University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.1016/j.jse.2009.07.064DOI Listing
April 2010
22 Reads
10 Citations
2.290 Impact Factor

Caffeic acid phenethyl ester, an active component of honeybee propolis attenuates osteoclastogenesis and bone resorption via the suppression of RANKL-induced NF-kappaB and NFAT activity.

J Cell Physiol 2009 Dec;221(3):642-9

Molecular Orthopaedic Laboratory, Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, Nedlands, Western Australia, Australia.

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http://dx.doi.org/10.1002/jcp.21898DOI Listing
December 2009
10 Reads
9 Citations
3.840 Impact Factor

Natural bone collagen scaffold combined with autologous enriched bone marrow cells for induction of osteogenesis in an ovine spinal fusion model.

Tissue Eng Part A 2009 Nov;15(11):3547-58

Centre for Orthopaedic Research, School of Surgery, University of Western Australia, Western Australia, Australia.

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http://dx.doi.org/10.1089/ten.TEA.2009.0076DOI Listing
November 2009
11 Reads
3 Citations

Natural bone collagen scaffold combined with OP-1 for bone formation induction in vivo.

J Biomed Mater Res B Appl Biomater 2009 Aug;90(2):778-88

Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, Western Australia 6009, Australia.

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http://dx.doi.org/10.1002/jbm.b.31347DOI Listing
August 2009
22 Reads
2.760 Impact Factor

Proteasome inhibitors impair RANKL-induced NF-kappaB activity in osteoclast-like cells via disruption of p62, TRAF6, CYLD, and IkappaBalpha signaling cascades.

J Cell Physiol 2009 Aug;220(2):450-9

Molecular Orthopaedic Laboratory, Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, Nedlands, Western Australia, Australia.

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http://dx.doi.org/10.1002/jcp.21787DOI Listing
August 2009
13 Reads
13 Citations
3.840 Impact Factor

Sequestosome 1 mutations in Paget's disease of bone in Australia: prevalence, genotype/phenotype correlation, and a novel non-UBA domain mutation (P364S) associated with increased NF-kappaB signaling without loss of ubiquitin binding.

J Bone Miner Res 2009 Jul;24(7):1216-23

Laboratory for Molecular Endocrinology, Western Australian Institute for Medical Research and UWA Centre for Medical Research, University of Western Australia, Nedlands, Australia.

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http://dx.doi.org/10.1359/jbmr.090214DOI Listing
July 2009
12 Reads
8 Citations
6.832 Impact Factor

NF-kappaB modulators in osteolytic bone diseases.

Cytokine Growth Factor Rev 2009 Feb 28;20(1):7-17. Epub 2008 Nov 28.

Centre for Orthopaedic Research, School of Surgery, University of Western Australia, Nedlands, Australia.

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http://dx.doi.org/10.1016/j.cytogfr.2008.11.007DOI Listing
February 2009
12 Reads
34 Citations
5.360 Impact Factor

Mutations within the TNF-like core domain of RANKL impair osteoclast differentiation and activation.

Mol Endocrinol 2009 Jan 13;23(1):35-46. Epub 2008 Nov 13.

Molecular Orthopaedics Laboratory, Centre for Orthopaedic Research, School of Surgery and Pathology, University of Western Australia, Queen Elizabeth II Medical Centre, Second Floor M Block, Nedlands, Western Australia 6009, Australia.

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http://dx.doi.org/10.1210/me.2007-0465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419323PMC
January 2009
10 Reads
3 Citations
4.022 Impact Factor

Scaffolds for tendon and ligament repair: review of the efficacy of commercial products.

Expert Rev Med Devices 2009 Jan;6(1):61-73

Centre for Orthopaedics Research, School of Surgery University of Western Australia, Room 2.33, 2nd Floor, M-Block, QEII Medical Centre, Nedlands, Perth, WA 6009, Australia.

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http://dx.doi.org/10.1586/17434440.6.1.61DOI Listing
January 2009
14 Reads
40 Citations
1.784 Impact Factor

Gene expression profiles of human chondrocytes during passaged monolayer cultivation.

J Orthop Res 2008 Sep;26(9):1230-7

Centre of Orthopaedic Surgery, University of Western Australia, M Block, QEII Medical Centre, Monash Avenue, Nedlands, Western Australia 6009, Australia.

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http://dx.doi.org/10.1002/jor.20523DOI Listing
September 2008
10 Reads
45 Citations
2.990 Impact Factor

Repression of human cytomegalovirus major immediate early gene expression by the cellular transcription factor CCAAT displacement protein.

Virology 2008 Sep 9;378(2):214-25. Epub 2008 Jul 9.

Centre for Virus Research, Westmead Millennium Institute, PO Box 412, Westmead, New South Wales 2145, Australia.

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http://dx.doi.org/10.1016/j.virol.2008.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484626PMC
September 2008
10 Reads
5 Citations
3.321 Impact Factor

Evaluation of insoluble bone gelatin as a carrier for enhancement of osteogenic protein-1-induced intertransverse process lumbar fusion in a rabbit model.

Spine (Phila Pa 1976) 2008 Aug;33(18):1935-42

Centre for Orthopaedic Research, School of Surgery, University of Western Australia, Western Australia, Australia.

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http://dx.doi.org/10.1097/BRS.0b013e31817e1cf1DOI Listing
August 2008
50 Reads
1 Citation
2.300 Impact Factor

Cytoplasmic terminus of vacuolar type proton pump accessory subunit Ac45 is required for proper interaction with V(0) domain subunits and efficient osteoclastic bone resorption.

J Biol Chem 2008 May 28;283(19):13194-204. Epub 2008 Jan 28.

Molecular Orthopaedic Laboratory, Centre for Orthopaedic Research, School of Surgery and Pathology, University of Western Australia, Nedlands, Western Australia 6009, Australia.

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http://dx.doi.org/10.1074/jbc.M709712200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442344PMC
May 2008
14 Reads
12 Citations
4.573 Impact Factor

Calcium/calmodulin-dependent kinase activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand (RANKL).

J Cell Physiol 2007 Sep;212(3):787-95

Molecular Orthopedic Laboratory, School of Surgery and Pathology, University of Western Australia, Nedlands, WA, Australia.

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http://dx.doi.org/10.1002/jcp.21076DOI Listing
September 2007
16 Reads
19 Citations
3.840 Impact Factor

Autologous tenocyte therapy using porcine-derived bioscaffolds for massive rotator cuff defect in rabbits.

Tissue Eng 2007 Jul;13(7):1479-91

Department of Orthopaedic Surgery, School of Surgery and Pathology, University of Western Australia, Nedlands, Australia.

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http://dx.doi.org/10.1089/ten.2006.0266DOI Listing
July 2007
19 Reads
22 Citations
4.254 Impact Factor

Matrix-induced autologous chondrocyte implantation (MACI): biological and histological assessment.

Tissue Eng 2007 Apr;13(4):737-46

Department of Orthopaedics, School of Pathology and Surgery, University of Western Australia, Nedlands, Perth, Australia.

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http://dx.doi.org/10.1089/ten.2006.0246DOI Listing
April 2007
15 Reads
24 Citations
4.254 Impact Factor

p62 ubiquitin binding-associated domain mediated the receptor activator of nuclear factor-kappaB ligand-induced osteoclast formation: a new insight into the pathogenesis of Paget's disease of bone.

Am J Pathol 2006 Aug;169(2):503-14

Molecular Orthopaedic Laboratory, School of Surgery and Pathology, University of Western Australia, QEII Medical Centre, 2nd Floor M Block, Nedlands, WA, Australia 6009.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698794PMC
August 2006
50 Reads
23 Citations
4.591 Impact Factor

The chondrocyte: biology and clinical application.

Tissue Eng 2006 Jul;12(7):1971-84

Department of Orthopaedic Surgery, Faculty of Medicine and Dentistry, University of Western Australia, Western Australia 6009, Australia.

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http://dx.doi.org/10.1089/ten.2006.12.1971DOI Listing
July 2006
40 Reads
30 Citations
4.254 Impact Factor

A novel mutation (K378X) in the sequestosome 1 gene associated with increased NF-kappaB signaling and Paget's disease of bone with a severe phenotype.

J Bone Miner Res 2006 Jul;21(7):1136-45

Laboratory for Molecular Endocrinology, Western Australian Institute for Medical Research, University of Western Australia, Nedlands.

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http://dx.doi.org/10.1359/jbmr.060405DOI Listing
July 2006
26 Reads
16 Citations
6.832 Impact Factor

Fibrin sealant promotes migration and proliferation of human articular chondrocytes: possible involvement of thrombin and protease-activated receptors.

Int J Mol Med 2006 Apr;17(4):551-8

School of Surgery and Pathology (Orthopaedics), The University of Western Australia, Crawley WA 6009, Australia.

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April 2006
27 Reads
10 Citations
1.880 Impact Factor

Deletion of aspartate 182 in OPG causes juvenile Paget's disease by impairing both protein secretion and binding to RANKL.

J Bone Miner Res 2006 Mar 14;21(3):438-45. Epub 2005 Nov 14.

Department of Medicine, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1359/JBMR.051104DOI Listing
March 2006
21 Reads
6 Citations
6.832 Impact Factor

Thapsigargin modulates osteoclastogenesis through the regulation of RANKL-induced signaling pathways and reactive oxygen species production.

J Bone Miner Res 2005 Aug 28;20(8):1462-71. Epub 2005 Mar 28.

Molecular Orthopaedic Laboratory, School of Surgery and Pathology, and Western Australian Institute for Medical Research, Nedlands, WA 6009, Australia.

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http://dx.doi.org/10.1359/JBMR.050324DOI Listing
August 2005
34 Reads
17 Citations
6.832 Impact Factor

Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption.

Mol Cell Biol 2005 Jun;25(12):5253-69

Unit of Orthopaedics, School of Surgery and Pathology, University of Western Australia, 2nd Floor M Block, QEII Medical Centre, Nedlands, Perth, Western Australia 6009, Australia.

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http://dx.doi.org/10.1128/MCB.25.12.5253-5269.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1140603PMC
June 2005
9 Reads
27 Citations
4.780 Impact Factor

Evidence of reciprocal regulation between the high extracellular calcium and RANKL signal transduction pathways in RAW cell derived osteoclasts.

J Cell Physiol 2005 Feb;202(2):554-62

Molecular Orthopaedic Laboratory, School of Surgery and Pathology, University of Western Australia, Nedlands WA, Australia.

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http://dx.doi.org/10.1002/jcp.20159DOI Listing
February 2005
11 Reads
3 Citations
3.840 Impact Factor

Sesquiterpene lactone parthenolide blocks lipopolysaccharide-induced osteolysis through the suppression of NF-kappaB activity.

J Bone Miner Res 2004 Nov 27;19(11):1905-16. Epub 2004 Sep 27.

Molecular Orthopaedic Laboratory, School of Surgery and Pathology, University of Western Australia, Nedlands, Western Australia, Australia.

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http://dx.doi.org/10.1359/JBMR.040919DOI Listing
November 2004
16 Reads
13 Citations
6.832 Impact Factor

Thapsigargin potentiates TRAIL-induced apoptosis in giant cell tumor of bone.

Bone 2004 Jun;34(6):971-81

Department of Orthopaedics and Traumatology, the Chinese University of Hong Kong, Shatin, N.T., Hongkong SAR, China.

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http://dx.doi.org/10.1016/j.bone.2004.02.005DOI Listing
June 2004
6 Reads
4 Citations

12-O-tetradecanoylphorbol-13-acetate (TPA) inhibits osteoclastogenesis by suppressing RANKL-induced NF-kappaB activation.

J Bone Miner Res 2003 Dec;18(12):2159-68

Department of Orthopaedics, University of Western Australia, Nedlands, Western Australia, Australia.

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http://dx.doi.org/10.1359/jbmr.2003.18.12.2159DOI Listing
December 2003
27 Reads
24 Citations
6.832 Impact Factor

Expression and localization of extracellular matrix metalloproteinase inducer in giant cell tumor of bone.

J Cell Biochem 2003 Aug;89(6):1154-63

Department of Orthopaedic Surgery, University of Western Australia, Nedlands, WA. [corrected].

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http://dx.doi.org/10.1002/jcb.10578DOI Listing
August 2003
22 Reads
2 Citations
3.263 Impact Factor

Expression of caltrin in the baculovirus system and its purification in high yield and purity by cobalt (II) affinity chromatography.

Protein Expr Purif 2003 Jun;29(2):284-90

Department of Orthopaedic Surgery, University of Western Australia, Nedlands, WA 6009, Australia.

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June 2003
8 Reads
1 Citation
1.700 Impact Factor

Effects of Bafilomycin A1: an inhibitor of vacuolar H (+)-ATPases on endocytosis and apoptosis in RAW cells and RAW cell-derived osteoclasts.

J Cell Biochem 2003 Apr;88(6):1256-64

Department of Surgery (Orthopaedics), University of Western Australia, QEII Medical Center, Nedlands WA.

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http://dx.doi.org/10.1002/jcb.10477DOI Listing
April 2003
10 Reads
17 Citations
3.263 Impact Factor

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Ming H Zheng
Ming H Zheng

School of Surgery

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Nathan J Pavlos
Nathan J Pavlos

University of Western Australia

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Shek Man Chim
Shek Man Chim

University of Western Australia

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Jennifer Tickner
Jennifer Tickner

School of Pathology and Laboratory Medicine

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Zhen Lin
Zhen Lin

Tsinghua University

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James H Steer
James H Steer

University of Western Australia

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Jimin Chen
Jimin Chen

University of Western Australia

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Ming-Hao Zheng
Ming-Hao Zheng

University of Western Australia

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