Publications by authors named "Jiahao Chen"

80 Publications

A Survey of Brain-Inspired Intelligent Robots: Integration of Vision, Decision, Motion Control, and Musculoskeletal Systems.

IEEE Trans Cybern 2021 Apr 28;PP. Epub 2021 Apr 28.

Current robotic studies are focused on the performance of specific tasks. However, such tasks cannot be generalized, and some special tasks, such as compliant and precise manipulation, fast and flexible response, and deep collaboration between humans and robots, cannot be realized. Brain-inspired intelligent robots imitate humans and animals, from inner mechanisms to external structures, through an integration of visual cognition, decision making, motion control, and musculoskeletal systems. This kind of robot is more likely to realize the functions that current robots cannot realize and become human friends. With the focus on the development of brain-inspired intelligent robots, this article reviews cutting-edge research in the areas of brain-inspired visual cognition, decision making, musculoskeletal robots, motion control, and their integration. It aims to provide greater insight into brain-inspired intelligent robots and attracts more attention to this field from the global research community.
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http://dx.doi.org/10.1109/TCYB.2021.3071312DOI Listing
April 2021

Microscopic Afterglow Bioimaging by Ultralong Organic Phosphorescent Nanoparticles in Living Cells and Zebrafish.

Anal Chem 2021 04 14;93(16):6516-6522. Epub 2021 Apr 14.

Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, China.

Compared with short-lived emission probes featuring fluorescence imaging , the use of phosphorescent probes imparts the advantage of long-lived signal persistence that distinguishes against background fluorescence interference. However, the realization of ultralong organic phosphorescent (UOP) probes with an ultralong emission lifetime in an aqueous medium is still a challenge. Here, we present a rational strategy for obtaining UOP nanoparticles (NPs) in an air-saturated aqueous medium prepared using an organic phosphor (PDBCz) and a surfactant polymer (PVP), named PDBCz@PVP, showing an ultralong emission lifetime of 284.59 ms and a phosphorescence quantum efficiency of 7.6%. The excellent phosphorescence properties and water solubility of PDBCz@PVP make it a promising candidate for biological imaging. The as-prepared PDBCz@PVP NPs possess excellent luminescence intensity as well as illustrious biocompatibility both in vitro and in vivo. We demonstrate their use as an efficient phosphorescent nanoprobe both in living cells and zebrafish by capturing their afterglow emission signals under microscopy observation for the first time, realizing convenient and fast bioimaging with low cost, which allows for anti-fluorescence interference and shows promise for the future theragnostic applications in nanomedicine.
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http://dx.doi.org/10.1021/acs.analchem.1c00423DOI Listing
April 2021

Comparison of analgesic activities of aconitine in different mice pain models.

PLoS One 2021 1;16(4):e0249276. Epub 2021 Apr 1.

Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.

Aconitine (AC) is the primary bioactive and secondary metabolite alkaloidin of Aconitum species which is accounted for more than 60% of the total diester-diterpenoid alkaloids in Aconite. To evaluate the analgesic effects of AC, 4 different pain models including hot plate assay, acetic acid writhing assay, formalin and CFA induced pain models were adopted in this study. In hot plate experiment, AC treatment at concentration of 0.3 mg/kg and 0.9 mg/kg improved the pain thresholds of mice similar to the positive drug aspirin at the concentration of 200 mg/kg (17.12% and 20.27% VS 19.21%). In acetic acid writhing experiment, AC significantly reduced the number of mice writhing events caused by acetic acid, and the inhibition rates were 68% and 76%. These results demonstrated that AC treatment revealed significant analgesic effects in both acute thermal stimulus pain model and chemically-induced visceral pain model. The biphasic nociceptive responses induced by formalin were significantly inhibited after AC treatment for 1h or 2h. The inhibition rates were 33.23% and 20.25% of AC treatment for 1h at 0.3 mg/kg and 0.9 mg/kg in phase I. In phase II, the inhibition rates of AC and aspirin were 36.08%, 32.48% and 48.82% respectively, which means AC showed similar analgesic effect to non-steroidal anti-inflammatory compounds. In the chronic CFA-induced nociception model, AC treatment also improved mice pain threshold to 131.33% at 0.3 mg/kg, which was similar to aspirin group (152.03%). Above all, our results verified that AC had obviously analgesic effects in different mice pain models.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0249276PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8016268PMC
April 2021

MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism.

Cancer Cell 2021 Apr 4;39(4):529-547.e7. Epub 2021 Mar 4.

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Ruth L. and David S. Gottesman Institute for Stem Cell Research and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Division of Hemato-Oncology, Department of Medicine (Oncology), Albert Einstein College of Medicine - Montefiore Medical Center, Bronx, NY 10461, USA; Blood Cancer Institute, Albert Einstein College of Medicine - Montefiore Medical Center, Bronx, NY 10461, USA; Albert Einstein Cancer Center, Albert Einstein College of Medicine - Montefiore Medical Center, Bronx, NY 10461, USA. Electronic address:

MDMX is overexpressed in the vast majority of patients with acute myeloid leukemia (AML). We report that MDMX overexpression increases preleukemic stem cell (pre-LSC) number and competitive advantage. Utilizing five newly generated murine models, we found that MDMX overexpression triggers progression of multiple chronic/asymptomatic preleukemic conditions to overt AML. Transcriptomic and proteomic studies revealed that MDMX overexpression exerts this function, unexpectedly, through activation of Wnt/β-Catenin signaling in pre-LSCs. Mechanistically, MDMX binds CK1α and leads to accumulation of β-Catenin in a p53-independent manner. Wnt/β-Catenin inhibitors reverse MDMX-induced pre-LSC properties, and synergize with MDMX-p53 inhibitors. Wnt/β-Catenin signaling correlates with MDMX expression in patients with preleukemic myelodysplastic syndromes and is associated with increased risk of progression to AML. Our work identifies MDMX overexpression as a pervasive preleukemic-to-AML transition mechanism in different genetically driven disease subtypes, and reveals Wnt/β-Catenin as a non-canonical MDMX-driven pathway with therapeutic potential for progression prevention and cancer interception.
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http://dx.doi.org/10.1016/j.ccell.2021.02.006DOI Listing
April 2021

Association of Body Mass Index with Risk of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.

COPD 2021 Feb 16;18(1):101-113. Epub 2021 Feb 16.

Department of Epidemiology and Health Statistics, the School of Public, Health of Qingdao University, Qingdao, Shandong Province, China.

The association between body mass index (BMI) and chronic obstructive pulmonary disease (COPD) remains controversial. Therefore, a meta-analysis was conducted to further evaluate the relationship. A comprehensive literature search was performed in PubMed, Web of Science, EMBASE, China National Knowledge Infrastructure (CNKI), and Wanfang databases to identify eligible articles until July 15, 2020. Random effect model (REM) was used to compute the pooled results with 95% confidence intervals (CIs). We conducted meta-regression and subgroup analysis to explore potential sources of heterogeneity. Publication bias was evaluated by funnel plots and Egger's test. Thirty articles with 1,578,449 participants were included in the meta-analysis. The pooled OR of COPD was 1.96 (95% CI: 1.78-2.17) for the underweight group, 0.80 (95% CI: 0.73-0.87) for overweight group, and 0.86 (95% CI: 0.73-1.02) for obesity group. After further excluding 5 studies of high between-study heterogeneity in sensitivity analysis, the pooled OR of COPD was 0.77 (95% CI: 0.68-0.86) for the obesity group. This meta-analysis indicated that BMI was associated with COPD. Specifically, underweight might increase the risk of COPD; overweight and obesity might reduce the risk of COPD.
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http://dx.doi.org/10.1080/15412555.2021.1884213DOI Listing
February 2021

Antiferromagnetic half-skyrmions and bimerons at room temperature.

Nature 2021 02 3;590(7844):74-79. Epub 2021 Feb 3.

Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.

In the quest for post-CMOS (complementary metal-oxide-semiconductor) technologies, driven by the need for improved efficiency and performance, topologically protected ferromagnetic 'whirls' such as skyrmions and their anti-particles have shown great promise as solitonic information carriers in racetrack memory-in-logic or neuromorphic devices. However, the presence of dipolar fields in ferromagnets, which restricts the formation of ultrasmall topological textures, and the deleterious skyrmion Hall effect, when skyrmions are driven by spin torques, have thus far inhibited their practical implementation. Antiferromagnetic analogues, which are predicted to demonstrate relativistic dynamics, fast deflection-free motion and size scaling, have recently become the subject of intense focus, but they have yet to be experimentally demonstrated in natural antiferromagnetic systems. Here we realize a family of topological antiferromagnetic spin textures in α-FeO-an Earth-abundant oxide insulator-capped with a platinum overlayer. By exploiting a first-order analogue of the Kibble-Zurek mechanism, we stabilize exotic merons and antimerons (half-skyrmions) and their pairs (bimerons), which can be erased by magnetic fields and regenerated by temperature cycling. These structures have characteristic sizes of the order of 100 nanometres and can be chemically controlled via precise tuning of the exchange and anisotropy, with pathways through which further scaling may be achieved. Driven by current-based spin torques from the heavy-metal overlayer, some of these antiferromagnetic textures could emerge as prime candidates for low-energy antiferromagnetic spintronics at room temperature.
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http://dx.doi.org/10.1038/s41586-021-03219-6DOI Listing
February 2021

Calm Hu ram lambs assigned by temperament classification are healthier and have better meat quality than nervous Hu ram lambs.

Meat Sci 2021 May 9;175:108436. Epub 2021 Jan 9.

School of Agriculture and Environment, The University of Western Australia, Crawley 6009, WA, Australia.

The objective of this study was to evaluate the effects of temperament classification (assessed using an arena test) on health and productivity of Hu ram lambs. In experiment one, eight ram lambs classified as calm and eight classified as nervous (selected from 100 ram lambs) were fed individually for 60-days to compare food intake, food digestibility, weight gain, and biochemical indices of health. In experiment two, nine ram lambs classified as calm and nine classified as nervous (selected from 150 ram lambs) were fed in a group and slaughter traits, meat quality, and muscle histology were compared. Calm lambs had higher dry matter digestibility, lower serum TNF-α, higher total antioxidant capacity, higher total superoxide dismutase activity, higher dressing percentage, higher cross-sectional area of loin, higher myofibre density, lower ultimate pH of the meat, and higher meat redness, than nervous lambs. Selection for calm temperament could be beneficial to health, slaughter, and carcass traits in Hu ram lambs.
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http://dx.doi.org/10.1016/j.meatsci.2021.108436DOI Listing
May 2021

Influence of Alanine Transaminase Levels on Alpha-Fetoprotein for Predicting Hepatocellular Carcinoma in Patients with Hepatitis B Infection.

Biomed Res Int 2020 15;2020:2043715. Epub 2020 Dec 15.

Department of Laboratory Medicine, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Purpose: To investigate the influence of alanine transaminase (ALT) on the accuracy of alpha-fetoprotein (AFP) for detecting hepatocellular carcinoma (HCC).

Methods: This retrospective study recruited 799 patients with HCC, cirrhosis, and chronic hepatitis due to hepatitis B infection and healthy adults between July 2017 and January 2019. Comparisons of the area under the receiver operating characteristic curves (AUCs) for detecting HCC in different ALT levels were calculated.

Results: Serum ALT and gamma-glutamyl transferase levels were significantly associated with elevated AFP in patients without HCC. The AUC of AFP was higher in patients with ALT ≤ 2 upper limit of normal (ULN) than in patients with ALT > 2 ULN (0.806 vs. 0.611, < 0.001). Nevertheless, there were no significant differences in the AUCs of AFP/(ALT × aspartate aminotransferase (AST)) in patients with ALT ≤ 2 ULN and with ALT > 2 ULN (0.745 vs. 0.769, = 0.68). AFP/(ALT × AST) was better than AFP in patients with ALT > 2 ULN for detecting HCC ( < 0.001).

Conclusions: Higher ALT levels might impair the accuracy of AFP for diagnosing HCC. AFP tests showed better accuracy in patients with ALT ≤ 2 ULN whereas the AFP/(ALT × AST) ratio was recommended in patients with elevated ALT levels.
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http://dx.doi.org/10.1155/2020/2043715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787738PMC
December 2020

Case report of combination therapy with Azacytidine, Enasidenib and Venetoclax in primary refractory AML.

Exp Hematol Oncol 2021 Jan 4;10(1). Epub 2021 Jan 4.

Albert Einstein College of Medicine, Department of Hematology/Oncology, Bronx, NY, USA.

Optimal treatment of acute myeloid leukemia (AML) arising in elderly patients remains a challenge. FDA approval of Ivosidenib and Enasidenib, small molecule inhibitors of isocitrate dehydrogenase enzymes (IDH1 and 2) have opened new avenues of treatment. We present a 60-year-old woman with refractory AML, achieving complete response to the combination therapy of hypomethylating agent, Azacytidine with the IDH2 inhibitor, Enasidenib, and BCL2 inhibitor, Venetoclax. To our knowledge, this is the first case report of a patient with IDH2 mutated refractory AML achieving complete response to combination therapy with azacytidine, enasidenib and venetoclax.
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http://dx.doi.org/10.1186/s40164-020-00186-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784272PMC
January 2021

The synergistic role of Pu.1 and Fms in zebrafish osteoclast-reducing osteopetrosis and possible therapeutic strategies.

J Genet Genomics 2020 09 12;47(9):535-546. Epub 2020 Oct 12.

Division of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou, 510006, China. Electronic address:

Osteoclasts are bone resorption cells of myeloid origin. Osteoclast defects can lead to osteopetrosis, a genetic disorder characterized by bone sclerosis for which there is no effective drug treatment. It is known that Pu.1 and Fms are key regulators in myelopoiesis, and their defects in mice can lead to reduced osteoclast numbers and consequent osteopetrosis. Yet how Pu.1 and Fms genetically interact in the development of osteoclasts and the pathogenesis of osteopetrosis is still unclear. Here, we characterized pu.1;fms double-deficient zebrafish, which exhibited a greater deficiency of functional osteoclasts and displayed more severe osteopetrotic symptoms than the pu.1 or fms single mutants, suggesting a synergistic function of Pu.1 and Fms in the regulation of osteoclast development. We further demonstrated that Pu.1 plays a dominant role in osteoclastogenesis, whereas Fms plays a dominant role in osteoclast maturation. Importantly, treatment with the drug retinoic acid significantly relieved the different degrees of osteopetrosis symptoms in these models by increasing the number of functional osteoclasts. Thus, we report the development of valuable animal models of osteopetrosis, and our results shed light on drug development for antiosteopetrosis therapy.
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http://dx.doi.org/10.1016/j.jgg.2020.09.002DOI Listing
September 2020

The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs.

Toxicol Res (Camb) 2020 Sep 31;9(5):609-621. Epub 2020 Aug 31.

Department of Occupational Health and Occupational Medicine, School of Public Health, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Shandong, Jinan, 250012, China.

This study investigated whether valproic acid (VPA, a histone deacetylase inhibitor) can interfere with the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs). A typical representative compound of PAHs, 7,12-Dimethylbenz[a]anthracene (DMBA), was used to induce rat breast cancer. The results showed that therapeutic concentration of VPA (50 and 100 mg/kg) delayed the occurrence of tumors, reduced tumor formation rate and attenuated tumors growth, and have a protective effect on normal tissues. The macrophage-mediated inflammatory response was found to be associated with the observed effect of VPA. In addition, we screened and validated a possible gene, , which was involved in DMBA-induced breast cancer development and can be inhibited by VPA.
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http://dx.doi.org/10.1093/toxres/tfaa069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7640934PMC
September 2020

The impact of individual lifestyle and status on the acquisition of COVID-19: A case-Control study.

PLoS One 2020 5;15(11):e0241540. Epub 2020 Nov 5.

Department of Critical Care Medicine, Suzhou Dushu Lake Hospital (Dushu Lake Hospital Affiliated to Soochow University), Suzhou, Jiangsu, China.

Background: Coronavirus disease 2019 (COVID-19) has spread to the world. Whether there is an association between lifestyle behaviors and the acquisition of COVID-19 remains unclear.

Methods: In this case-control study, we recruited 105 patients with SARS-CoV-2 infection as a case group from the Wuhan Tongji Hospital (Wuhan, China). For each case two control subjects were recruited. Participants were randomly selected from communities in Wuhan and matched for sex, age (± 2yrs), and pre-existing comorbidities (hypertension and diabetes).

Results: A total of 105 patients diagnosed with COVID-19 and 210 controls were included. Compared with control group, the case group had higher proportions of lack of sleep (30.5% vs. 14.8%, P = 0.001) and increased physical activities (56.2% vs. 32.9%, P < 0.001). And patients in the case group were more likely to have alopecia (28.6% vs. 10.0%, P < 0.001) than people from the control group. Overall, we found that lack of sleep [adjusted odds ratio (OR) 1.56, 95% confidence interval (CI) 1.03-2.39)], physical activities (≥ 5 times a week) (adjusted OR 2.05, 95%CI 1.39-3.02) and alopecia (adjusted OR 1.73, 95%CI 1.13-2.66) were independent risk factors for COVID-19 infection. Conversely, low-dose alcohol intake (<100g alcohol per week), hand hygiene, and fruits intake (daily) were significantly associated with a decrease in morbidity.

Conclusions: Individual lifestyle behaviors and health status can affect the occurrence of COVID-19.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0241540PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643946PMC
November 2020

Unsupervised Dark-Channel Attention-Guided CycleGAN for Single-Image Dehazing.

Sensors (Basel) 2020 Oct 23;20(21). Epub 2020 Oct 23.

National Key Laboratory of Fundamental Science on Synthetic Vision, Chengdu 610000, China.

In this paper, we propose a new unsupervised attention-based cycle generative adversarial network to solve the problem of single-image dehazing. The proposed method adds an attention mechanism that can dehaze different areas on the basis of the previous generative adversarial network (GAN) dehazing method. This mechanism not only avoids the need to change the haze-free area due to the overall style migration of traditional GANs, but also pays attention to the different degrees of haze concentrations that need to be changed, while retaining the details of the original image. To more accurately and quickly label the concentrations and areas of haze, we innovatively use training-enhanced dark channels as attention maps, combining the advantages of prior algorithms and deep learning. The proposed method does not require paired datasets, and it can adequately generate high-resolution images. Experiments demonstrate that our algorithm is superior to previous algorithms in various scenarios. The proposed algorithm can effectively process very hazy images, misty images, and haze-free images, which is of great significance for dehazing in complex scenes.
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http://dx.doi.org/10.3390/s20216000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660183PMC
October 2020

Charge Accumulation of Amplified Spontaneous Emission in a Conjugated Polymer Chain and Its Dynamical Phonon Spectra.

Molecules 2020 Jun 30;25(13). Epub 2020 Jun 30.

Department of Physics, Zhejiang Normal University, Jinhua 321004, China.

In this article, the detailed photoexcitation dynamics which combines nonadiabatic molecular dynamics with electronic transitions shows the occurrence of amplified spontaneous emission (ASE) in conjugated polymers, accompanied by spontaneous electric polarization. The elaborate molecular dynamic process of ultrafast photoexcitation can be described as follows: Continuous external optical pumping (laser of 70 µJ/cm) not only triggers the appearance of an instantaneous four-level electronic structure but causes population inversion for ASE as well. At the same time, the phonon spectrum of the conjugated polymer changes, and five local infrared lattice vibrational modes form at the two ends, which break the original symmetry in the system and leads to charge accumulation at the ends of the polymer chain without an external electric field. This novel phenomenon gives a brand-new avenue to explain how the lattice vibrations play a role in the evolution of the stimulated emission, which leads to an ultrafast effect in solid conjugated polymers.
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http://dx.doi.org/10.3390/molecules25133003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412338PMC
June 2020

Electrochemical Investigation of Redox Processes of Labile Cu(II)/Cu(I)-Cl Complexes by Scanning Electrochemical Microscopy.

Anal Chem 2020 Aug 17;92(15):10420-10424. Epub 2020 Jul 17.

School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an 710072, P. R. China.

The studies reported here provide detailed information on the kinetics and reaction mechanism determined by the scanning electrochemical microscopy (SECM) for Cu(II)/Cu(I) redox reactions in a system with excess chloride. In positive feedback mode, the tip voltammograms obtained consist of two partially overlapping reduction waves, not one quasi-reversible process as was always thought. The reduced species of CuCl and [CuCl(HO)] could coexist during the time scale of SECM measurements, due to the slowness of the ligand substitution reaction of [CuCl(HO)] to CuCl. The stepwise EC reactions of CuCl have experienced the same electron transfer kinetics as do outer-sphere reactants, while the reactions of [CuCl(HO)] followed concerted EC pathways and much lower rate constants can be obtained, mainly due to the nonadiabatic character of electron transfer (/ = 1.625). The findings of this study can offer valuable insights for analyzing the electrode kinetics of labile complexes of metals in aqueous solutions.
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http://dx.doi.org/10.1021/acs.analchem.0c00797DOI Listing
August 2020

Alcohol, Alcoholic Beverages and Risk of Esophageal Cancer by Histological Type: A Dose-Response Meta-Analysis of Observational Studies.

Alcohol Alcohol 2020 Aug;55(5):457-467

Department of Epidemiology and Health Statistics, The School of Public Health of Qingdao University, 308 Ningxia Road, Qingdao, Shandong 266071, People's Republic of China.

Aims: We conducted a dose-response meta-analysis to explore the association between alcohol and particular alcoholic beverages with risk of esophageal cancer (EC) by histological type [esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)] and whether the association differs according to gender.

Methods: PubMed and Web of Science databases were searched for relevant articles published between January 1960 and December 2019. The pooled relative ratios (RRs) and 95% confidence interval (CI) were calculated with the fixed or random effect model. The dose-response relationship was assessed by restricted cubic spline.

Results: A total of 74 published articles involving 31,105 cases among 3,369,024 participants were included in this meta-analysis. The pooled RRs of the highest versus lowest alcohol intake were 3.67 (95% CI, 2.89,4.67) for EC, 5.11 (95% CI, 3.60,7.25) for ESCC and 0.96 (95% CI, 0.79,1.16) for EAC. The above-mentioned associations were observed in cohort design, for different alcoholic beverages (beer, wine and liquor/spirits) and gender. Evidence of a nonlinear dose-response relationship for EC risk with alcohol intake was found (Pnon-linearity < 0.001), and a linear relationship (Pnon-linearity = 0.216) suggested that the risk of ESCC increased by 33% for every 12.5 g/day increment of alcohol intake.

Conclusions: This meta-analysis suggests that alcohol intake might significantly increase the incidence of EC, especially for ESCC.
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http://dx.doi.org/10.1093/alcalc/agaa047DOI Listing
August 2020

Tripartite-motif family protein 35-28 regulates microglia development by preventing necrotic death of microglial precursors in zebrafish.

J Biol Chem 2020 06 12;295(26):8846-8856. Epub 2020 May 12.

Shenzhen Key Laboratory for Neuronal Structural Biology, Biomedical Research Institute, Shenzhen Peking University- The Hong Kong University of Science and Technology Medical Center, Shenzhen, China; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Center of Systems Biology and Human Health, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China; Greater Bay Biomedical Innocenter, Shenzhen Bay Laboratory, Shenzhen, China. Electronic address:

Microglia are tissue-resident macrophages in the central nervous system (CNS) that play essential roles in the regulation of CNS development and homeostasis. Yet, the genetic networks governing microglia development remain incompletely defined. Here, we report the identification and characterization of a microglia-defective zebrafish mutant ( ) isolated from an ethylnitrosourea (ENU)-based genetic screen. We show that mutants harbors a missense point mutation in the gene region encoding the PRY/SPRY domain of the tripartite-motif family protein 35-28 () gene. Time-lapse imaging revealed that the loss of Trim35-28 function causes lytic necrosis of microglial precursors/peripheral macrophages, as indicated by cytoplasmic swelling and membrane rupture of these precursors and accompanied by neutrophil infiltration and systemic inflammation. Intriguingly, the lytic necrosis of microglial precursors in -deficient mutants appeared to depend neither on the canonical pyroptotic nor necroptotic pathways, as inhibition of the key component in each pathway could not rescue the microglia phenotype in -deficient mutants. Finally, results from tissue-specific rescue experiments suggested that Trim35-28 acts cell-autonomously in the survival of microglial precursors. Taken together, the findings of our study reveal Trim35-28 as a regulatory protein essential for microglia development.
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http://dx.doi.org/10.1074/jbc.RA119.012043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324517PMC
June 2020

Surface-Modified Sewage Sludge-Derived Carbonaceous Catalyst as a Persulfate Activator for Phenol Degradation.

Int J Environ Res Public Health 2020 05 8;17(9). Epub 2020 May 8.

College of Navigation, Dalian Maritime University, Dalian 116026, China.

In this study, a catalytic persulfate oxidation process comprising sodium persulfate (PS) and modified sewage sludge-derived carbonaceous catalysts was tested for the degradation of phenol. Sludge-based biochar was modified by high-temperature treatment combined with hydrochloric acid oxidation. The surface properties of carbonaceous catalysts before and after modification were characterized by elemental analysis, N isothermal adsorption-desorption, scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The effects of reaction parameters including catalyst dosage, PS/phenol molar ratio, initial pH and reaction temperature on the degradation rate of phenol were investigated. The kinetics of phenol transformation was explored and the reaction rate appeared pseudo first-order kinetics. In SS-600-HCl/PS system, 91% phenol could be efficiently degraded under certain reaction conditions ([phenol] = 100 mg/L, catalyst dosage = 0.8 g/L, PS/phenol molar ratio = 3/1, pH = 7, 25 °C) in 180 min. Thus, the results showed that the modified sewage sludge-derived carbonaceous catalyst had a better ability to activate PS for phenol degradation.
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http://dx.doi.org/10.3390/ijerph17093286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246733PMC
May 2020

Stronger Stimulation of Waste Activated Sludge Anaerobic Fermentation by a Particular Amount of Micron-Sized Zero Valent Iron.

Appl Biochem Biotechnol 2020 Sep 6;192(1):313-324. Epub 2020 May 6.

College of Architecture and Environment, Sichuan University, Chengdu, 610065, China.

An emerging contaminant, micron-sized zero valent iron (mZVI) has been reported to be accumulated in waste activated sludge (WAS). In the present study, the potential effects of mZVI on WAS anaerobic fermentation performance, as well as the shift of the microbial community composition and function, were assessed. Results from batch experiments indicated that a particular concentration of mZVI (1.5 g/L, in the range of 0.0 to 5.0 g/L) improved volatile fatty acids (VFA) accumulation by 4.84 times that in the control group, the ability (dosage dependent) to remove phosphorus, and the dewaterability of fermented WAS from 126 ± 5 s (control group) to 104 ± 3 s (group with 1.5 g/L mZVI). Furthermore, high-throughput sequencing revealed that mZVI had no significant impact on the shift of microbial community structure, but directly stimulated the functional performance related to anaerobic fermentation. This study will provide new insights into the mZVI application and its effect on WAS utilization.
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http://dx.doi.org/10.1007/s12010-020-03339-1DOI Listing
September 2020

Association of dietary ω-3 and ω-6 fatty acids intake with cognitive performance in older adults: National Health and nutrition examination Survey (NHANES) 2011-2014.

Nutr J 2020 03 28;19(1):25. Epub 2020 Mar 28.

Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, 38 Deng Zhou Street, Qingdao, 266021, Shandong Province, China.

Background: Current evidence on the association of dietary ω-3 and ω-6 fatty acids intake with cognitive performance is inconsistent. Therefore, the aim is to explore the association of dietary ω-3 and ω-6 fatty acids intake with cognitive performance in the U.S. noninstitutionalized population of older adults.

Methods: We used data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Intakes of ω-3 and ω-6 fatty acids were obtained through two 24-h dietary recalls and were adjusted by energy. Cognitive performance was evaluated by the Consortium to Establish a Registry for Alzheimer's disease (CERAD) Word Learning sub-test, Animal Fluency test and Digit Symbol Substitution Test (DSST). For each cognitive test, people who scored lower than the lowest quartile in each age group were defined as having low cognitive performance. Binary logistic regression and restricted cubic spline models were applied to evaluate the association of dietary ω-3 and ω-6 fatty acids intake with cognitive performance.

Results: A total of 2496 participants aged 60 years or older were included. In the full-adjusted model, the odds ratios (ORs) with 95% confidence interval (CI) of CERAD test score, Animal Fluency test score and DSST test score were 0.58 (0.38-0.88), 0.68 (0.47-0.99) and 0.59 (0.37-0.92) for the highest versus lowest tertile of dietary ω-3 fatty acids intake, respectively; the ORs with 95% CI of CERAD test score, Animal Fluency test score and DSST test score were 0.48 (0.31-0.75), 0.60 (0.40-0.92) and 0.50 (0.34-0.75) for the highest versus lowest tertile of dietary ω-6 fatty acids intake, respectively. The association between ω-6: ω-3 ratio and cognitive performance was not statistically significant in three tests. In dose-response relationship analysis, L-shaped associations were apparent for ω-3 and ω-6 fatty acids intake with CERAD test score, Animal Fluency test score and DSST test score.

Conclusions: Dietary ω-3 and ω-6 fatty acids intake might be inversely associated with low cognitive performance.
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http://dx.doi.org/10.1186/s12937-020-00547-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103069PMC
March 2020

Supramolecular Energy Materials.

Adv Mater 2020 Apr 12;32(17):e1907247. Epub 2020 Mar 12.

Department of Chemistry, Northwestern University, Evanston, IL, 60208, USA.

Self-assembly is a bioinspired strategy to craft materials for renewable and clean energy technologies. In plants, the alignment and assembly of the light-harvesting protein machinery in the green leaf optimize the ability to efficiently convert light from the sun to form chemical bonds. In artificial systems, strategies based on self-assembly using noncovalent interactions offer the possibility to mimic this functional correlation among molecules to optimize photocatalysis, photovoltaics, and energy storage. One of the long-term objectives of the field described here as supramolecular energy materials is to learn how to design soft materials containing light-harvesting assemblies and catalysts to generate fuels and useful chemicals. Supramolecular energy materials also hold great potential in the design of systems for photovoltaics in which intermolecular interactions in self-assembled structures, for example, in electron donor and acceptor phases, maximize charge transport and avoid exciton recombination. Possible pathways to integrate organic and inorganic structures by templating strategies and electrodeposition to create materials relevant to energy challenges including photoconductors and supercapacitors are also described. The final topic discussed is the synthesis of hybrid perovskites in which organic molecules are used to modify both structure and functions, which may include chemical stability, photovoltaics, and light emission.
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http://dx.doi.org/10.1002/adma.201907247DOI Listing
April 2020

Nitrogen and Phosphorus Co-doped Porous Carbon for High-Performance Supercapacitors.

Front Chem 2020 20;8:105. Epub 2020 Feb 20.

School of Materials Science and Engineering, Jiangxi University of Science and Technology, Ganzhou, China.

As one of the most promising fast energy storage devices, supercapacitor has been attracting intense attention for many emerging applications. However, how to enhance the electrochemical performance of electrode materials is still the main issue among various researches. In this paper, hierarchical porous carbons derived from has been prepared by chemical activation process with the aid of KOH at elevated temperature. Results show that the N, P co-doped porous carbon exhibits excellent electrochemical performance, it owns a specific capacitance of 340.2 F/g at 1 A/g, and obtains outstanding cycling stability of 96.9% of capacitance retention at 10 A/g after 5,000 cycles in a three-electrode system. Moreover, in the two-electrode system, the product still maintains a high specific capacitance of 227.2 F/g at 1 A/g, and achieves good electrochemical cycle stability (94.2% of capacitance retention at 10 A/g after 10,000 cycles); besides, its power/energy density are 3694.084 and 26.289 Wh/kg, respectively. Therefore, the combination of facile synthesis strategy and excellent electrochemical performance makes -based porous carbon as a promising electrode material for supercapacitor.
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http://dx.doi.org/10.3389/fchem.2020.00105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045068PMC
February 2020

Co-delivery of brinzolamide and miRNA-124 by biodegradable nanoparticles as a strategy for glaucoma therapy.

Drug Deliv 2020 Dec;27(1):410-421

Shanghai General Hospital, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai engineering center for precise diagnosis and treatment of eye diseases, Shanghai, China.

Co-delivery nanoparticles with characteristics of intracellular precision release drug have been generally accepted as an effective therapeutic strategy for eye diseases. In this study, we designed a new co-delivery system (miRNA/NP-BRZ) as a lasting therapeutic approach to prevent the neuro-destructive after the long-term treatment of glaucoma. Neuroprotective and intraocular pressure (IOP) response were assessed in and models of glaucoma. At the meaning time, we describe the preparation of miRNA/NP-BRZ, drug release characteristics, intraocular tracing, pharmacokinetic and pharmacodynamics study and toxicity test. We found that miRNA/NP-BRZ could remarkably decrease IOP and significantly prevent retinal ganglion cell (RGC) damages. The new formula of miRNA-124 encapsulated in PEG-PSA-BRZ nanoparticles exhibits high encapsulation efficiency (EE), drug-loading capacity (DC), and stable controlled-release efficacy (EC). Moreover, we also verified that the miRNA/NP-BRZ system is significantly neuroprotective and nontoxic as well as lowering IOP. This study shows our co-delivery drug system would have a wide potential on social and economic benefits for glaucoma.
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http://dx.doi.org/10.1080/10717544.2020.1731861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067192PMC
December 2020

Photoexcitation-induced local phonon spectra and local hot excitons in polymer solar cells.

Opt Express 2020 Jan;28(2):1385-1393

In this article, based on nonadiabatic molecular dynamics with electronic transitions, the elaborate ultrafast process of hot excitons in conjugated polymer solar cells is revealed. When an external optical beam/pulse with the intensity of 30 µJ/cm is utilized to excite a conjugated polymer, just within only 50 fs, the electronic transition not only redistributes the electron population in the original molecular orbital, but also starts to localize the electron cloud of excited states and to distort the alternating bonds in the polymer chain. Up to 300 fs, the lattice distortion has been stabilized. During the formation of hot excitons, the prominent self-trapping effect of conjugated polymer triggers the occurrence of local infrared active phonon modes, with five peaks in the phonon spectrum as the hot excitons relax. The characteristic phonon spectrum and infrared modes hence form the fingerprint of the hot excitons of a conjugated polymer, which are readily distinguished from other excitation states in the polymer.
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http://dx.doi.org/10.1364/OE.28.001385DOI Listing
January 2020

Assessing the Microbial Communities in Four Different Daqus by Using PCR-DGGE, PLFA, and Biolog Analyses.

Pol J Microbiol 2020 ;69:1-11

Hunan Wuling Spirits Co., Ltd. , Changde , China.

Daqu made from raw wheat, barley or pea is used as an inoculum for the fermentation of Chinese Baijiu. In this study, the microbial communities of four different types of Daqus (sauce-flavor Wuling Daqu, sauce and strong-flavor Baisha Daqu, strong-flavor Deshan Daqu, and light-flavor Niulanshan Daqu) were analyzed by polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE), phospholipid fatty acid (PLFA) analysis, and Biolog EcoPlates analysis (Biolog). Clear differences were seen between the microbial communities of the four Daqus. PCR-DGGE showed differences in the number and brightness of bands between the Daqus, indicating the presence of unique bacterial species in Deshan Daqu, Wuling Daqu, and Niulanshan Daqu. , , and some unclassified bacteria were unique to Wuling Daqu, Deshan Daqu, and Niulanshan Daqu, respectively. Moreover, some bacterial species were observed in all four Daqus. A total of 26 PLFAs between C12 to C20 were detected from the four Daqus by PLFA analysis. Wuling Daqu had the highest total and fungal biomasses, Baisha Daqu had the highest bacterial biomass, and Niulanshan Daqu had the highest ratio of fungal biomass to bacterial biomass. The Biolog results indicated differences in the carbon source use and mode of the four Daqus, and also demonstrated that each Daqu had varying abilities to utilize different types of carbon sources. The cluster analysis of the three methods showed that the microbial communities of the four Daqus were different. This study also demonstrates the applicability of the three analytical methods in the evaluating of the microbial communities of Daqus.

Daqu made from raw wheat, barley or pea is used as an inoculum for the fermentation of Chinese Baijiu. In this study, the microbial communities of four different types of Daqus (sauce-flavor Wuling Daqu, sauce and strong-flavor Baisha Daqu, strong-flavor Deshan Daqu, and light-flavor Niulanshan Daqu) were analyzed by polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE), phospholipid fatty acid (PLFA) analysis, and Biolog EcoPlates analysis (Biolog). Clear differences were seen between the microbial communities of the four Daqus. PCR-DGGE showed differences in the number and brightness of bands between the Daqus, indicating the presence of unique bacterial species in Deshan Daqu, Wuling Daqu, and Niulanshan Daqu. , , and some unclassified bacteria were unique to Wuling Daqu, Deshan Daqu, and Niulanshan Daqu, respectively. Moreover, some bacterial species were observed in all four Daqus. A total of 26 PLFAs between C12 to C20 were detected from the four Daqus by PLFA analysis. Wuling Daqu had the highest total and fungal biomasses, Baisha Daqu had the highest bacterial biomass, and Niulanshan Daqu had the highest ratio of fungal biomass to bacterial biomass. The Biolog results indicated differences in the carbon source use and mode of the four Daqus, and also demonstrated that each Daqu had varying abilities to utilize different types of carbon sources. The cluster analysis of the three methods showed that the microbial communities of the four Daqus were different. This study also demonstrates the applicability of the three analytical methods in the evaluating of the microbial communities of Daqus.
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http://dx.doi.org/10.33073/pjm-2020-004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256838PMC
December 2020

Stem cell mutations can be detected in myeloma patients years before onset of secondary leukemias.

Blood Adv 2019 12;3(23):3962-3967

Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.

Therapy-related acute myeloid leukemia and myelodysplastic syndromes (t-AML/t-MDS) are secondary hematologic malignancies associated with poor prognosis, warranting insights into their predisposing conditions and cells of origin. We identified patients with myeloma who developed t-AML/t-MDS and analyzed their stem and progenitor cells collected years before the onset of secondary disease. We demonstrate that aberrant stem cells with high CD123 expression can be detected long before the onset of overt leukemia. Rigorous sorting, followed by targeted sequencing, resulted in ultradeep functional depth of sequencing and revealed preexisting mutant hematopoietic stem cell (HSC) clones, mainly harboring TP53 mutations, that became the dominant population at the time of leukemic presentation. Taken together, these data show that HSCs can act as reservoirs for leukemia-initiating cells many years before the onset of myeloid leukemia.
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http://dx.doi.org/10.1182/bloodadvances.2019000731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963234PMC
December 2019

Long noncoding RNA LINC00899 suppresses breast cancer progression by inhibiting miR-425.

Aging (Albany NY) 2019 11 18;11(22):10144-10153. Epub 2019 Nov 18.

Department of Laboratory Medicine, Key Laboratory of Liver Disease of Guangdong Province, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, P.R. China.

Long non-coding RNAs (lncRNAs) have emerged as important regulators in cancer, including breast cancer. The precise expression pattern of long noncoding RNA 00899 (LINC00899) in breast cancer and its mechanisms of action have not been reported. Here, we found that LINC00899 is downregulated in breast cancer tissues and cell lines. Kaplan-Meier analysis showed that elevated LINC00899 expression is closely associated with better relapse-free survival (RFS) in breast cancer, including the basal, luminal A or luminal B breast cancer subtypes. Gene Ontology terms and Kyoto Encyclopedia of Genes and Genomes pathway analysis suggested that LINC00899 is closely related to several cancer associated processes, including tight junction- and metabolism-associated pathways. Functional assays indicated that LINC00899 overexpression suppresses proliferation, migration and invasion of breast cancer cells in vitro. Moreover, LINC00899 was found to competitively bind miR-425, thereby functioning as a tumor suppressor by enhancing DICER1. Overexpression of miR-425 attenuated the LINC00899-induced inhibition of breast cancer cell proliferation and invasion. These findings highlight the important role of the LINC00899-miR-425-DICER1 axis in breast cancer cell proliferation and invasion, and could potentially lead to new lncRNA-based diagnostics or therapeutics for breast cancer.
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http://dx.doi.org/10.18632/aging.102426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914403PMC
November 2019

Long-term clinical safety and efficacy of drug-coated balloon in the treatment of in-stent restenosis: A meta-analysis and systematic review.

Catheter Cardiovasc Interv 2020 08 12;96(2):E129-E141. Epub 2019 Nov 12.

Department of Cardiology, The Dongguan Affiliated Hospital (Dongguan 5th People's Hospital), Jinan University School of Medicine, Dongguan, China.

Objectives: The aim of this study was to evaluate the long-term clinical safety and efficacy of drug-coated balloon (DCB) in the treatment of in-stent restenosis (ISR).

Background: There is a long-term safety issue in peripheral arterial disease patients treated with paclitaxel-coated balloon, this has also raised concerns on DCB in coronary intervention.

Methods: Nine randomized controlled trials (RCTs) and nine observational studies (OSs) were included with a total of 3,782 patients (1,827 in the DCB group, 1,955 in the drug-eluting stent [DES] group) being analyzed. The primary outcome measure-major adverse cardiovascular events (MACEs), target lesion revascularization (TLR), target vessel revascularization (TVR), myocardial infarction (MI), cardiac death (CD), stent thrombosis (ST), all-cause death (AD), and coronary angiography outcomes included late lumen loss (LLL), minimum luminal diameter (MLD), diameter stenosis (DS) were analyzed.

Results: DCB treatment significantly reduced the LLL (MD: -0.13; [CI -0.23 to -0.03], p = .01). No difference was found for MLD (MD: -0.1; [CI -0.24 to 0.04], p = .17) and DS% (RR = 0.98 [CI 0.80-1.20], p = .86). There was no significant difference in TLR, TVR, MI, CD, ST, AD, and the overall incidence of MACEs between the two groups up to 3 years follow-up. Subgroup analysis for different type of ISR and DES showed no significant difference in the incidence of endpoints, and there is no difference when considering RCTs or OSs only.

Conclusions: The safety and efficacy of the DCB and DES in the treatment of ISR is comparable at up to 3 years follow-up.
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http://dx.doi.org/10.1002/ccd.28572DOI Listing
August 2020

An Ectopic Chemokine Expression Model for Testing Macrophage Recruitment In Vivo.

J Vis Exp 2019 09 25(151). Epub 2019 Sep 25.

Division of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology;

Zebrafish are widely used in basic and biomedical research. Many zebrafish transgenic lines are currently available to label various types of cells. Owing to the transparent embryonic body of zebrafish, it is convenient for us to study the effect of one chemokine on the behavior of a certain type of cells in vivo. Here we provided a workflow to investigate the function of a chemokine on macrophage migration in vivo. We constructed a tissue-specific overexpression plasmid to overexpress IL-34 and injected the plasmid into one-cell stage transgenic fish embryos whose macrophages were specifically labeled by a fluorescent protein. We then used whole mount fluorescent in situ hybridization and immunostaining to detect the pattern of the chemokine expression and the number or location of macrophages. The injected WT embryos were raised to generate a stable transgenic line. Finally, we used confocal live imaging to directly observe macrophage behavior in the stable transgenic fish to study the function of IL-34 on macrophages in vivo.
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http://dx.doi.org/10.3791/60161DOI Listing
September 2019

Palladium(0)-Catalyzed Directed syn-1,2-Carboboration and -Silylation: Alkene Scope, Applications in Dearomatization, and Stereocontrol by a Chiral Auxiliary.

Angew Chem Int Ed Engl 2019 11 8;58(47):17068-17073. Epub 2019 Oct 8.

Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, 92037, USA.

We report the development of palladium(0)-catalyzed syn-selective 1,2-carboboration and -silylation reactions of alkenes containing cleavable directing groups. With B pin or PhMe Si-Bpin as nucleophiles and aryl/alkenyl triflates as electrophiles, a broad range of mono-, di-, tri- and tetrasubstituted alkenes are compatible in these transformations. We further describe a directed dearomative 1,2-carboboration of electron-rich heteroarenes by employing this approach. Through use of a removable chiral directing group, we demonstrate the viability of achieving stereoinduction in Heck-type alkene 1,2-difunctionalization. This work introduces new avenues to access highly functionalized boronates and silanes with precise regio- and stereocontrol.
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http://dx.doi.org/10.1002/anie.201910304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337986PMC
November 2019