Publications by authors named "Jiachen Zhou"

28 Publications

  • Page 1 of 1

Associations between cancer family history and esophageal cancer and precancerous lesions in high-risk areas of China.

Chin Med J (Engl) 2022 Jan 13. Epub 2022 Jan 13.

Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, China National Central Cancer Registry, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Background: Family clustering of esophageal cancer (EC) has been found in high-risk areas of China. However, the relationships between cancer family history and esophageal cancer and precancerous lesions (ECPL) have not been comprehensively reported in recent years. This study aimed to provide evidence for identification of high-risk populations.

Methods: This study was conducted in five high-risk areas in China from 2017 to 2019, based on the National Cohort of Esophageal Cancer. The permanent residents aged 40 to 69 years were examined by endoscopy, and pathological examination was performed for suspicious lesions. Information on demographic characteristics, environmental factors, and cancer family history was collected. Unconditional logistic regression was applied to evaluate odds ratios between family history related factors and ECPL.

Results: Among 33,008 participants, 6143 (18.61%) reported positive family history of EC. The proportion of positive family history varied significantly among high-risk areas. After adjusting for risk factors, participants with a family history of positive cancer, gastric and esophageal cancer or EC had 1.49-fold (95% confidence interval [CI]: 1.36-1.62), 1.52-fold (95% CI: 1.38-1.67), or 1.66-fold (95% CI: 1.50-1.84) higher risks of ECPL, respectively. Participants with single or multiple first-degree relatives (FDR) of positive EC history had 1.65-fold (95% CI: 1.47-1.84) or 1.93-fold (95% CI: 1.46-2.54) higher risks of ECPL. Participants with FDRs who developed EC before 35, 45, and 50 years of age had 4.05-fold (95% CI: 1.30-12.65), 2.11-fold (95% CI: 1.37-3.25), and 1.91-fold (95% CI: 1.44-2.54) higher risks of ECPL, respectively.

Conclusions: Participants with positive family history of EC had significantly higher risk of ECPL. This risk increased with the number of EC positive FDRs and EC family history of early onset. Distinctive genetic risk factors of the population in high-risk areas of China require further investigation.

Trial Registration: http://www.chictr.org.cn/, ChiCTR-EOC-17010553.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/CM9.0000000000001939DOI Listing
January 2022

Prediction models for gastric cancer risk in the general population: a systematic review.

Cancer Prev Res (Phila) 2022 Jan 11. Epub 2022 Jan 11.

National Central Cancer Registry, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Risk prediction models for gastric cancer (GC) could identify high-risk individuals in the general population. The objective of this study was to systematically review the available evidence about the construction and verification of GC predictive models. We searched PubMed, Embase, and Cochrane Library databases for articles that developed or validated GC risk prediction models up to November 2021. Data extracted included study characteristics, predictor selection, missing data, and evaluation metrics. Risk of bias (ROB) was assessed using the Prediction model study Risk Of Bias Assessment Tool (PROBAST). We identified a total of 12 original risk prediction models that fulfilled the criteria for analysis. The area under the receiver operating characteristic curve ranged from 0.73 to 0.93 in derivation sets (n=6), 0.68 to 0.90 in internal validation sets (n=5), 0.71 to 0.92 in external validation sets (n=7). The higher-performing models usually include age, salt preference, Helicobacter pylori, smoking, BMI, family history, pepsinogen and sex. According to PROBAST, at least one domain with a high ROB was present in all studies mainly due to methodologic limitations in the analysis domain. In conclusion, although some risk prediction models including similar predictors have displayed sufficient discriminative abilities, many have a high ROB due to methodological limitations and are not externally validated efficiently. Future prediction models should adherence to well-established standards and guidelines to benefit GC screening.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1158/1940-6207.CAPR-21-0426DOI Listing
January 2022

Risk Prediction Model for Esophageal Cancer Among General Population: A Systematic Review.

Front Public Health 2021 1;9:680967. Epub 2021 Dec 1.

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

The risk prediction model is an effective tool for risk stratification and is expected to play an important role in the early detection and prevention of esophageal cancer. This study sought to summarize the available evidence of esophageal cancer risk predictions models and provide references for their development, validation, and application. We searched PubMed, EMBASE, and Cochrane Library databases for original articles published in English up to October 22, 2021. Studies that developed or validated a risk prediction model of esophageal cancer and its precancerous lesions were included. Two reviewers independently extracted study characteristics including predictors, model performance and methodology, and assessed risk of bias and applicability with PROBAST (Prediction model Risk Of Bias Assessment Tool). A total of 20 studies including 30 original models were identified. The median area under the receiver operating characteristic curve of risk prediction models was 0.78, ranging from 0.68 to 0.94. Age, smoking, body mass index, sex, upper gastrointestinal symptoms, and family history were the most commonly included predictors. None of the models were assessed as low risk of bias based on PROBST. The major methodological deficiencies were inappropriate date sources, inconsistent definition of predictors and outcomes, and the insufficient number of participants with the outcome. This study systematically reviewed available evidence on risk prediction models for esophageal cancer in general populations. The findings indicate a high risk of bias due to several methodological pitfalls in model development and validation, which limit their application in practice.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpubh.2021.680967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671165PMC
December 2021

Global patterns of breast cancer incidence and mortality: A population-based cancer registry data analysis from 2000 to 2020.

Cancer Commun (Lond) 2021 11 16;41(11):1183-1194. Epub 2021 Aug 16.

Office for Cancer Registry, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, P. R. China.

Background: Breast cancer is the most commonly diagnosed cancer and leading cause of cancer death among women worldwide but has patterns and trends which vary in different countries. This study aimed to evaluate the global patterns of breast cancer incidence and mortality and analyze its temporal trends for breast cancer prevention and control.

Methods: Breast cancer incidence and mortality data in 2020 were obtained from the GLOBOCAN online database. Continued data from the Cancer Incidence in Five Continents Time Trends, the International Agency for Research on cancer mortality and China National Central Cancer Registry were used to analyze the time trends from 2000 to 2015 through Joinpoint regression, and annual average percent changes of breast cancer incidence and mortality were calculated. Association between Human Development Index and breast cancer incidence and mortality were estimated by linear regression.

Results: There were approximately 2.3 million new breast cancer cases and 685,000 breast cancer deaths worldwide in 2020. Its incidence and mortality varied among countries, with the age-standardized incidence ranging from the highest of 112.3 per 100,000 population in Belgium to the lowest of 35.8 per 100,000 population in Iran, and the age-standardized mortality from the highest of 41.0 per 100,000 population in Fiji to the lowest of 6.4 per 100,000 population in South Korea. The peak age of breast cancer in some Asian and African countries were over 10 years earlier than in European or American countries. As for the trends of breast cancer, the age-standardized incidence rates significantly increased in China and South Korea but decreased in the United States of America (USA) during 2000-2012. Meanwhile, the age-standardized mortality rates significantly increased in China and South Korea but decreased in the United Kingdom, the USA, and Australia during 2000 and 2015.

Conclusions: The global burden of breast cancer is rising fast and varies greatly among countries. The incidence and mortality rates of breast cancer increased rapidly in China and South Korea but decreased in the USA. Increased health awareness, effective prevention strategies, and improved access to medical treatment are extremely important to curb the snowballing breast cancer burden, especially in the most affected countries.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/cac2.12207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626596PMC
November 2021

Surveillance of premalignant gastric cardia lesions: A population-based prospective cohort study in China.

Int J Cancer 2021 11 7;149(9):1639-1648. Epub 2021 Jul 7.

Office of National Central Cancer Registry, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

In our study, we aimed to assess the long-term risk of gastric cardia adenocarcinoma (GCA) for patients with different histological cardia lesions to inform future guidelines for GCA screening in China. We conducted a population-based prospective study among 9740 subjects who underwent upper endoscopy screening during 2005 to 2009 and followed until December 2017. Cumulative incidence and mortality rates of GCA were calculated by the baseline histological diagnoses, and the hazard ratios (HRs), overall and by age and sex, were analyzed by Cox proportional hazards models. During a median follow-up of 10 years, we identified 123 new GCA cases (1.26%) and 31 GCA deaths (0.32%). The age-standardized incidence and mortality rates of GCA were 128.71/100 000 and 35.69/100 000 person-years, and cumulative incidence rate in patients with cardia high-grade dysplasia (CHGD), cardia low-grade dysplasia (CLGD) and atrophic carditis (AC)/cardia intestinal metaplasia (CIM) was 25%, 3.05% and 1.58%, respectively. The progression rate and cancer risk of GCA increased monotonically with each step in Correa's cascade. Individuals aged 50 to 69 years had 4.4 times higher GCA incidence than those aged 40 to 49 years. Patients with CLGD had a significantly higher 3-year GCA incidence than the normal group, while patients with AC/CIM had a comparable GCA risk during 3-year follow-up but a higher risk at 5-year intervals. Our results suggested a postponed starting age of 50 years for GCA screening, immediate treatment for patients with CHGD, a 3-year surveillance interval for patients with CLGD, and a lengthened surveillance interval of 5 years for patients with AC/CIM.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.33720DOI Listing
November 2021

Colorectal cancer burden and trends: Comparison between China and major burden countries in the world.

Chin J Cancer Res 2021 Feb;33(1):1-10

National Central Cancer Registry, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Objective: To summarize the colorectal cancer (CRC) burden and trend in the world, and compare the difference of CRC burden between other countries and China.

Methods: Incidence and mortality data were extracted from the GLOBOCAN2018 and Cancer Incidence in Five Continents. Age-specific incidence trend was conducted by Joinpoint analysis and average annual percent changes were calculated.

Results: About 1.85 million new cases and 0.88 million deaths were expected in 2018 worldwide, including 0.52 million (28.20%) new cases and 0.25 million (28.11%) deaths in China. Hungary had the highest age-standardized incidence and mortality rates in the world, while for China, the incidence and mortality rates were only half of that. CRC incidence and mortality were highly correlated with human development index (HDI). Unlike the rapid increase in Republic of Korea and the downward trend in Canada and Australia, the age-standardized incidence rates by world standard population in China and Norway were rising gradually. The age-specific incidence rate in the age group of 50-59 years in China was increasing rapidly, while in Republic of Korea and Canada, the fastest growing age group was 30-39 years.

Conclusions: The variations of CRC burden reflect the difference of risk factors, as well as levels of HDI and screening (early detection activities). The burden of CRC in China is high, and the incidence of CRC continues to increase, which may lead to a sustained increase in the burden of CRC in China in the future. Screening should be expanded to control CRC, and focused on young people in China.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2021.01.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7941684PMC
February 2021

Signatures within esophageal microbiota with progression of esophageal squamous cell carcinoma.

Chin J Cancer Res 2020 Dec;32(6):755-767

National Central Cancer Registry, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Objective: Esophageal squamous cell carcinoma (ESCC) is one of the dominant malignances worldwide, but currently there is less focus on the microbiota with ESCC and its precancerous lesions.

Methods: Paired esophageal biopsy and swab specimens were obtained from 236 participants in Linzhou, China. Data from 16S ribosomal RNA gene sequencing were processed using quantitative insights into microbial ecology (QIIME2) and R Studio to evaluate differences. The Wilcoxon rank sum test and Kruskal-Wallis rank sum test were used to compare diversity and characteristic genera by specimens and participant groups. Ordinal logistic regression model was used to build microbiol prediction model.

Results: Microbial diversity was similar between biopsy and swab specimens, including operational taxonomic unit (OTU) numbers and Shannon index. There were variations and similarities of esophageal microbiota among different pathological characteristics of ESCC. Top 10 relative abundance genera in all groups include , , , , , , , , and . Genus , , and showed significantly difference in disease groups when compared to normal control, whereas showed an increasing tendency with the progression of ESCC and others showed a decreasing tendency. About models based on all combinations of characteristic genera, only taken and into model, the prediction performance was the ideal one, of which the area under the curve (AUC) was 0.738.

Conclusions: Esophageal biopsy and swab specimens could yield similar microbial characterization. The combination of and has the potential to predict the progression of ESCC, which is needed to confirm by large-scale, prospective cohort studies.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.06.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797230PMC
December 2020

Lead-time bias in esophageal cancer screening in high-risk areas in China.

Chin J Cancer Res 2020 Aug;32(4):467-475

Cancer Registry Office, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.

Objective: To investigate what extent lead-time bias is likely to affect endoscopic screening effectiveness for esophageal cancer in the high-risk area in China.

Methods: A screening model based on the epidemiological cancer registry data, yielding a population-level incidence and mortality rates, was carried out to simulate study participants in the high-risk area in China, and investigate the effect of lead-time bias on endoscopic screening with control for length bias.

Results: Of 100,000 participants, 6,150 (6.15%) were diagnosed with esophageal squamous dysplasia during the 20-year follow-up period. The estimated lead time ranged from 1.67 to 5.78 years, with a median time of 4.62 years [interquartile range (IQR): 4.07-5.11 years] in the high-risk area in China. Lead-time bias exaggerated screening effectiveness severely, causing more than a 10% overestimation in 5-year cause-specific survival rate and around a 43% reduction in cause-specific hazard ratio. The magnitude of lead-time bias on endoscopic screening for esophageal cancer varied depending on the screening strategies, in which an inverted U-shaped and U-shaped effects were observed in the 5-year cause-specific survival rate and cause-specific hazard ratio respectively concerning a range of ages for primary screening.

Conclusions: Lead-time bias, usually causing an overestimation of screening effectiveness, is an elementary and fundamental issue in cancer screening. Quantification and correction of lead-time bias are essential when evaluating the effectiveness of endoscopic screening in the high-risk area in China.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.21147/j.issn.1000-9604.2020.04.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491548PMC
August 2020

Gas-Phase Photoelectrocatalysis for Breaking Down Nitric Oxide.

Environ Sci Technol 2019 06 14;53(12):7145-7154. Epub 2019 May 14.

International Joint Laboratory of Resource Chemistry SHNU-NUS-PU, Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials , Shanghai Normal University , Shanghai , 200234 PRC.

Photoelectrocatalysis (PEC) produces high-efficiency electron-hole separation by applying a bias voltage between semiconductor-based electrodes to achieve high photocatalytic reaction rates. However, using PEC to treat polluted gas in a gas-phase reaction is difficult because of the lack of a conductive medium. Herein, we report an efficient PEC system to oxidize NO gas by using parallel photoactive composites (TiO nanoribbons-carbon nanotubes) coated on stainless-steel mesh as photoanodes in a gas-phase chamber and Pt foil as the working electrode in a liquid-phase auxiliary cell. Carbon nanotubes (CNTs) were utilized as conductive scaffolds to enhance the interaction between TiO and stainless-steel skeletons for accelerated photogenerated electron transfer. Such a PEC system exhibited super-high performance for the treatment of indoor NO gas (550 ppb) with high selectivity for nitrate under UV-light irradiation owing to the conductive, intertwined network structure of the photoanode, fast photocarrier separation, and longer photogenerated hole lifetime. The photogenerated holes were proven to be the most important active sites for directly driving PEC oxidation of indoor NO gas, even in the absence of water vapor. This work created an efficient PEC air-purification filter for treating indoor polluted air under ambient conditions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.est.9b00986DOI Listing
June 2019

Efficient and Stable Perovskite Photodetectors Based on Thiocyanate-Assisted Film Formation.

ACS Appl Mater Interfaces 2019 Apr 10;11(16):14510-14514. Epub 2019 Apr 10.

Interdisciplinary Materials Research Center, School of Materials Science and Engineering , Tongji University , Shanghai 201804 , P. R. China.

Thiocyanate-based perovskite (SCN-PVSK) photodetectors have been fabricated by introducing lead thiocyanate precursor. Incorporating SCN groups into CHNHPbI can significantly improve the device stability in air. Compared with pure CHNHPbI films, SCN-PVSK films have larger grain size and reduced trap states. The perovskite layers can be prepared by a simple solution method in air. Solvent effects on the crystallization of SCN-PVSK films have also been investigated. It is found that highly uniform, pinhole-free perovskite films can be obtained utilizing the N,N-dimethylformamide (DMF) solution of Pb(SCN). The SCN-PVSK based photodetectors performed a high responsivity of 12.3 A/W and a decent detectivity over 1.3 × 10 Jones. More important, the SCN-PVSK based two-terminal photodetectors, without encapsulation, have shown great stability with 92% of the initial photocurrent being retained after storage in air (relative humidity >50%) for 10 days, whereas the value is only 10% for pure CHNHPbI devices tested under the same conditions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.9b01715DOI Listing
April 2019

A flexible CdS nanorods-carbon nanotubes/stainless steel mesh photoanode for boosted photoelectrocatalytic hydrogen evolution.

Chem Commun (Camb) 2019 Feb;55(19):2741-2744

Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai 200234, China.

An innovative flexible reticular photoanode (CdS-nanorods/CNTs coated on stainless iron mesh) was designed for efficiently driving photoelectrocatalytic (PEC) hydrogen (H2) evolution under visible-light irradiation. Such CdS-NRs/CNTs-based flexible photoanodes exhibited a record-breaking H2 evolution rate (728 mmol h-1 g-1) among the reported CdS-based photoanodes under visible-light irradiation owing to the photoelectron transport channels (CNTs) and high separation efficiency of electrons and holes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9cc00050jDOI Listing
February 2019

Hybrid Field-Effect Transistors and Photodetectors Based on Organic Semiconductor and CsPbI Perovskite Nanorods Bilayer Structure.

Nanomicro Lett 2018 23;10(4):57. Epub 2018 Jun 23.

Key Laboratory of Road and Traffic Engineering of Ministry of Education, Tongji University, Shanghai, 201804, People's Republic of China.

The outstanding performances of nanostructured all-inorganic CsPbX (X = I, Br, Cl) perovskites in optoelectronic applications can be attributed to their unique combination of a suitable bandgap, high absorption coefficient, and long carrier lifetime, which are desirable for photodetectors. However, the photosensing performances of the CsPbI nanomaterials are limited by their low charge-transport efficiency. In this study, a phototransistor with a bilayer structure of an organic semiconductor layer of 2,7-dioctyl [1] benzothieno[3,2-b] [1] benzothiophene and CsPbI nanorod layer was fabricated. The high-quality CsPbI nanorod layer obtained using a simple dip-coating method provided decent transistor performance of the hybrid transistor device. The perovskite layer efficiently absorbs light, while the organic semiconductor layer acts as a transport channel for injected photogenerated carriers and provides gate modulation. The hybrid phototransistor exhibits high performance owing to the synergistic function of the photogating effect and field effect in the transistor, with a photoresponsivity as high as 4300 A W, ultra-high photosensitivity of 2.2 × 10, and excellent stability over 1 month. This study provides a strategy to combine the advantages of perovskite nanorods and organic semiconductors in fabrication of high-performance photodetectors.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40820-018-0210-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199102PMC
June 2018

Intrinsically ionic conductive cellulose nanopapers applied as all solid dielectrics for low voltage organic transistors.

Nat Commun 2018 07 16;9(1):2737. Epub 2018 Jul 16.

Interdisciplinary Materials Research Center, School of Materials Science and Engineering, Tongji University, 201804, Shanghai, China.

Biodegradability, low-voltage operation, and flexibility are important trends for the future organic electronics. High-capacitance dielectrics are essential for low-voltage organic field-effect transistors. Here we report the application of environmental-friendly cellulose nanopapers as high-capacitance dielectrics with intrinsic ionic conductivity. Different with the previously reported liquid/electrolyte-gated dielectrics, cellulose nanopapers can be applied as all-solid dielectrics without any liquid or gel. Organic field-effect transistors fabricated with cellulose nanopaper dielectrics exhibit good transistor performances under operation voltage below 2 V, and no discernible drain current change is observed when the device is under bending with radius down to 1 mm. Interesting properties of the cellulose nanopapers, such as ionic conductivity, ultra-smooth surface (~0.59 nm), high transparency (above 80%) and flexibility make them excellent candidates as high-capacitance dielectrics for flexible, transparent and low-voltage electronics.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-05155-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048164PMC
July 2018

Integration of Biomaterials into Sensors Based on Organic Thin-Film Transistors.

Macromol Rapid Commun 2018 Aug 22;39(15):e1800084. Epub 2018 May 22.

Interdisciplinary Materials Research Center, School of Materials Science and Engineering, Tongji University, Shanghai, 201804, P. R. China.

Sensors based on organic thin-film transistors (OTFTs) present various advantages, including high sensitivity and mechanical flexibility, thus possessing potential applications such as wearable devices and biomedical electronics for health monitoring, etc. However, such applications are partially limited by the biocompatibility, biodegradability, and sensitivity to target analytes of OTFT-based sensors, which can be improved by the incorporation of diverse biomaterials. This article presents a brief review from the viewpoint of the type of the integrated biomaterials, including naturally occurring biomacromolecules such as proteins, enzymes, and deoxyribonucleic acid, as well as biocompatible polymers such as polylactide, poly(lactide-co-glycolide), poly(ethylene glycol), cellulose, polydimethylsiloxane, parylene, etc. It is believed that future work in this field should be devoted to the selectivity, sensitivity, and stability improvement as well as the high-level integration and sophistication on the basis of the OTFT-based sensors for physical, chemical, and biological sensing applications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/marc.201800084DOI Listing
August 2018

Distinguishable Detection of Ultraviolet, Visible, and Infrared Spectrum with High-Responsivity Perovskite-Based Flexible Photosensors.

Small 2018 May 14;14(19):e1800527. Epub 2018 Apr 14.

School of Material Science and Engineering, Tongji University, Shanghai, 201804, P. R. China.

Distinguishable detection of the ultraviolet, visible, and infrared spectrum is promising and significant for the super visual system of artificial intelligences. However, it is challenging to provide a photosensor with such broad spectral response ability. In this work, the ultraviolet, visible, and infrared spectrum is distinguished by developing serial photosensors based on perovskite/carbon nanotube hybrids. Oraganolead halide perovskites (CH NH PbX ) possess remarkable optoelectronic properties and tunable optical band gaps by changing the halogens, and integration with single-walled carbon nanotubes can further improve their photoresponsivities. The CH NH PbCl -based photosensor shows a responsivity up to 10 A W to ultraviolet and no obvious response to visible light, which is superior to that of most ultraviolet sensors. The CH NH PbBr -based photosensor exhibits a high responsivity to visible light. Serial devices of the two hybrid photosensors with comparable electric and sensory performances can distinguish the spectrum of ultraviolet, visible, and infrared even with varying light intensities. The photosensors also demonstrate excellent mechanical flexibility and bending stability. By taking full advantages of the oraganolead halide perovskites, this work provides flexible high-responsivity photosensors specialized for ultraviolet, and gives a simple strategy for distinguishable detection of ultraviolet, visible, and infrared spectrum based on the serial flexible photosensors.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/smll.201800527DOI Listing
May 2018

Photodetectors Based on Organic-Inorganic Hybrid Lead Halide Perovskites.

Adv Sci (Weinh) 2018 01 15;5(1):1700256. Epub 2017 Sep 15.

School of Materials Science and Engineering Tongji University Shanghai 201804 P. R. China.

Recent years have witnessed skyrocketing research achievements in organic-inorganic hybrid lead halide perovskites (OIHPs) in the photovoltaic field. In addition to photovoltaics, more and more studies have focused on OIHPs-based photodetectors in the past two years, due to the remarkable optoelectronic properties of OIHPs. This article summarizes the latest progress in this research field. To begin with, the factors influencing the performance of photodetectors are discussed, including both internal and external factors. In particular, the channel width and the incident power intensities should be taken into account to precisely and objectively evaluate and compare the output performance of different photodetectors. Next, photodetectors fabricated on single-component perovskites in terms of different micromorphologies are discussed, namely, 3D thin-film and single crystalline, 2D nanoplates, 1D nanowires, and 0D nanocrystals, respectively. Then, bilayer structured perovskite-based photodetectors incorporating inorganic and organic semiconductors are discussed to improve the optoelectronic performance of their pristine counterparts. Additionally, flexible OIHPs-based photodetectors are highlighted. Finally, a brief conclusion and outlook is given on the progress and challenges in the field of perovskites-based photodetectors.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/advs.201700256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770665PMC
January 2018

Preparation of Advanced CuO Nanowires/Functionalized Graphene Composite Anode Material for Lithium Ion Batteries.

Materials (Basel) 2017 Jan 17;10(1). Epub 2017 Jan 17.

School of Materials Science and Engineering, Tongji University, Shanghai, 201804, China.

The copper oxide (CuO) nanowires/functionalized graphene (f-graphene) composite material was successfully composed by a one-pot synthesis method. The f-graphene synthesized through the Birch reduction chemistry method was modified with functional group "-(CH₂)₅COOH", and the CuO nanowires (NWs) were well dispersed in the f-graphene sheets. When used as anode materials in lithium-ion batteries, the composite exhibited good cyclic stability and decent specific capacity of 677 mA·h·g after 50 cycles. CuO NWs can enhance the lithium-ion storage of the composites while the f-graphene effectively resists the volume expansion of the CuO NWs during the galvanostatic charge/discharge cyclic process, and provide a conductive paths for charge transportation. The good electrochemical performance of the synthesized CuO/f-graphene composite suggests great potential of the composite materials for lithium-ion batteries anodes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/ma10010072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344618PMC
January 2017

The authors reply.

Crit Care Med 2017 08;45(8):e872-e873

Department of Pharmacy, University of Maryland Medical Center, Baltimore, MD and Department of Pharmacy, Temple University Hospital, Philadelphia, PA;Hospital to Home Division, Philips Healthcare, Baltimore, MD.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000002506DOI Listing
August 2017

Facile Synthesis of a MoS and Functionalized Graphene Heterostructure for Enhanced Lithium-Storage Performance.

ACS Appl Mater Interfaces 2017 Apr 5;9(15):12907-12913. Epub 2017 Apr 5.

School of Materials Science and Engineering, Tongji University , Shanghai 201804, P. R. China.

A facile strategy was designed for the in situ synthesis of MoS nanospheres on functionalized graphene nanoplates ([email protected]) for use as lithium-ion battery anode materials. A modified Birch reduction was used to exfoliate graphite into few-layer graphene followed by modification with functional groups. Compared to the most common approach of mixing MoS and reduced graphene oxide, our approach provides a way to circumvent the harsh oxidation and destruction of the carbon basal planes. In this process, alkylcarboxyl functional groups on the functionalized graphene (f-graphene) serve as sites where MoS nanospheres crystallize, and thus create bridges between the MoS nanospheres and the graphene layers to effectively facilitate electronic transport and to avoid both the aggregation of MoS and the restacking of graphene. As anode materials, this unique [email protected] heterostructure has a high specific capacity of 1173 mAh g at a current density of 100 mA g and a good rate capacity (910 mAh g at 1600 mA g).
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.7b00248DOI Listing
April 2017

The Obesity Paradox Is Not Observed in Critically Ill Patients on Early Enteral Nutrition.

Crit Care Med 2017 May;45(5):828-834

1Department of Pharmacy, University of Maryland Medical Center, Baltimore, MD. 2Department of Pharmacy, Temple University Hospital, Philadelphia, PA. 3Philips Healthcare, Baltimore, MD.

Objectives: To investigate the association between body mass index and mortality in a large, ICU population and determine if the relationship is observed among a subgroup of patients ordered early enteral nutrition.

Design: Retrospective cohort study within a national clinical mixed ICU database of patients admitted between January 1, 2008, and June 30, 2015.

Setting: Initial ICU admissions among patients monitored by tele-ICU programs and recorded in the Philips eICU Research Institute database.

Patients: A total of 1,042,710 adult patient stays with ICU length of stay more than 24 hours, of which 74,771 were ordered enteral nutrition within the first 48 hours.

Intervention: None.

Measurements And Main Results: Patient stays from 409 ICUs were included. The average age, Acute Physiology and Chronic Health Evaluation IV score, and hospital mortality were 63.6 years, 56.7, and 9.0%, respectively. Hospital mortality among body mass index categories was estimated by multivariable modified Poisson regression models. Compared with the body mass index category 25.0-29.9 kg/m, hospital mortality was higher among underweight (body mass index, < 18.5; relative risk, 1.35; 95% CI, 1.32-1.39), normal weight (body mass index, 18.5-24.9; relative risk, 1.10; 95% CI, 1.09-1.12), and the extremely obese (body mass index, ≥ 50.0; relative risk, 1.10; 95% CI, 1.05-1.15). However, the risk was not statistically different from patients with body mass index 30.0-49.9 kg/m. Among patients ordered early enteral nutrition, the risk of mortality in the body mass index category 25.0-29.9 kg/m was not statistically different from those in the normal weight or extremely obese groups.

Conclusions: A survival advantage for overweight and obese patients was observed in this large cohort of critically ill patients. However, among those ordered early enteral nutrition, the survival disadvantage for body mass index categories less than 25.0 kg/m was minimal or unobservable when compared with higher body mass index categories.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000002326DOI Listing
May 2017

Photodetectors Based on Two-Dimensional Layer-Structured Hybrid Lead Iodide Perovskite Semiconductors.

ACS Appl Mater Interfaces 2016 Oct 21;8(39):25660-25666. Epub 2016 Sep 21.

School of Materials Science and Engineering, Tongji University , Shanghai, 201804, P. R. China.

Hybrid lead iodide perovskite semiconductors have attracted intense research interests recently because of their easy fabrication processes and high power conversion efficiencies in photovoltaic applications. Layer-structured materials have interesting properties such as quantum confinement effect and tunable band gap due to the unique two-dimensional crystalline structures. ⟨100⟩-oriented layer-structured perovskite materials are inherited from three-dimensional ABX perovskite materials with a generalized formula of (RNH)(CHNH)MX, and adopt the Ruddlesden-Popper type crystalline structure. Here we report the synthesis and investigation of three layer-structured perovskite materials with different layer numbers: (CHNH)PbI (n = 1, one-layered perovskite), (CHNH)(CHNH)PbI (n = 2, two-layered perovskite) and (CHNH)(CHNH)PbI (n = 3, three-layered perovskite). Their photoelectronic properties were investigated in related to their molecular structures. Photodetectors based on these two-dimensional (2D) layer-structured perovskite materials showed tunable photoresponse with short response time in milliseconds. The photodetectors based on three-layered perovskite showed better performances than those of the other two devices, in terms of output current, responsivity, I/I ratio, and response time, because of its smaller optical band gap and more condensed microstructure comparing the other two materials. These results revealed the relationship between the molecular structures, film microstructures and the photoresponse properties of 2D layer-structured hybrid perovskites, and demonstrated their potentials as flexible, functional, and tunable semiconductors in optoelectronic applications, by taking advantage of their tunable quantum well molecular structure.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.6b09489DOI Listing
October 2016

Lower Urinary Tract Symptoms and Risk of Bladder Cancer in Men: Results From the Health Professionals Follow-up Study.

Urology 2015 Jun 8;85(6):1312-8. Epub 2015 Apr 8.

Department of Epidemiology, School of Public Health, Brown University, Providence, RI; Department of Public Health and Community Medicine, Tufts University Medical School, Boston, MA. Electronic address:

Objective: To understand the association between lower urinary tract symptoms (LUTS) and risk of bladder cancer in a large cohort of men.

Methods: Using data from the Health Professionals Follow-up Study, we examined risk of bladder cancer in relation to severity of LUTS among 30,183 men. During the follow-up period from 1996 until 2010, 476 newly diagnosed cases of bladder cancer occurred. The Cox proportional hazards regression was used to adjust for potential confounders.

Results: Among men with severe LUTS, risk of bladder cancer was 64% higher (relative risk [RR], 1.64; 95% confidence interval [CI], 0.87-3.08) compared with men who reported no LUTS. Subjects with both voiding and storage dysfunction had a significantly higher risk of bladder cancer (RR, 1.60; 95% CI, 1.00-2.56). Among individual urinary symptoms, urinary hesitancy was strongly associated with bladder cancer; those who experienced urinary hesitancy at least 50% of the time had more than twice the risk of bladder cancer (RR, 2.21; 95% CI, 1.29-3.78).

Conclusion: Our findings suggest that LUTS, especially urinary hesitancy, are associated with the development of bladder cancer in men.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urology.2015.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479979PMC
June 2015

Indoor air pollution from solid fuels and peripheral blood DNA methylation: findings from a population study in Warsaw, Poland.

Environ Res 2014 Oct 7;134:325-30. Epub 2014 Sep 7.

Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.

DNA methylation is a potential mechanism linking indoor air pollution to adverse health effects. Fetal and early-life environmental exposures have been associated with altered DNA methylation and play a critical role in progress of diseases in adulthood. We investigated whether exposure to indoor air pollution from solid fuels at different lifetime periods was associated with global DNA methylation and methylation at the IFG2/H19 imprinting control region (ICR) in a population-based sample of non-smoking women from Warsaw, Poland. Global methylation and IFG2/H19 ICR methylation were assessed in peripheral blood DNA from 42 non-smoking women with Luminometric Methylation Assay (LUMA) and quantitative pyrosequencing, respectively. Linear regression models were applied to estimate associations between indoor air pollution and DNA methylation in the blood. Compared to women without exposure, the levels of LUMA methylation for women who had ever exposed to both coal and wood were reduced 6.70% (95% CI: -13.36, -0.04). Using both coal and wood before age 20 was associated with 6.95% decreased LUMA methylation (95% CI: -13.79, -0.11). Further, the negative correlations were more significant with exposure to solid fuels for cooking before age 20. There were no clear associations between indoor solid fuels exposure before age 20 and through the lifetime and IFG2/H19 ICR methylation. Our study of non-smoking women supports the hypothesis that exposure to indoor air pollution from solid fuels, even early-life exposure, has the capacity to modify DNA methylation that can be detected in peripheral blood.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envres.2014.08.017DOI Listing
October 2014

Fluid intake and risk of bladder cancer in the Nurses' Health Studies.

Int J Cancer 2014 Sep 20;135(5):1229-37. Epub 2014 Feb 20.

Department of Epidemiology School of Public Health, Brown University, Providence, RI; Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY.

Increase in fluid intake may reduce bladder cancer risk by decreasing the contact time between carcinogens in urine and bladder epithelium. However, this association has not been examined in a large cohort of women. The association between total fluid intake and bladder cancer risk in two large prospective women's cohorts with 427 incident bladder cancer cases was examined. Detailed information on total fluid intake was collected by repeated food frequency questionnaires over time. Multivariable relative risks (RRs) and 95% confidence intervals (95% CIs) were estimated by using Cox proportional hazards regression models. Results from the two cohorts were pooled together using the random-effects model. Using the average values from the earliest two dietary assessments and lowest quartile as reference, a suggestive inverse association was observed between total fluid intake and overall bladder cancer risk (RR: 0.83, 95% CI: 0.61-1.12, p-value for trend: 0.08), and invasive bladder cancer risk (RR: 0.47, 95% CI: 0.23-0.97, p-value for trend: 0.04). Among heavy cigarette smokers, women with the highest quartile of total fluid intake had a 38% decrease in bladder cancer risk (RR: 0.62, 95% CI: 0.41-0.93, p-value for trend: 0.02). The findings suggested that total fluid intake may reduce bladder cancer risk for female smokers, as well as reduce the risk of invasive bladder cancer.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.28764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213947PMC
September 2014

Determinants and spatial patterns of adult overweight and hypertension in a high HIV prevalence rural South African population.

Health Place 2012 Nov 18;18(6):1300-6. Epub 2012 Sep 18.

Department of Epidemiology, Public Health Program, Brown University, Providence, RI, USA.

We conducted a large population-based survey among adults measuring weight, height, and blood pressure nested within an HIV survey in rural KwaZulu-Natal, South Africa, to identify and characterize clusters of overweight and hypertension in a typical rural African population and to explore whether geographic clusters can be accounted for by established individual-level risk factors. 58.4% of the participants were overweight and 22.6% were hypertensive. One cluster of high prevalence of overweight (RR=1.50, p<0.001) was identified using Kulldorff spatial scan statistic as the most likely cluster, whereas a low-risk cluster was identified in the nearby high-density settlement area (RR=0.62, p<0.05). No geographic clusters of hypertension were identified. After controlling for age, sex, educational attainment, household wealth, marital status, place of residence, and HIV status, no spatial clustering of overweight remained. The results provided clear evidence for the localized clustering of overweight. Identification of clustering of chronic disease could provide additional insights into the prevention and control for the rural South African population.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.healthplace.2012.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989767PMC
November 2012

Smokeless tobacco and risk of head and neck cancer: evidence from a case-control study in New England.

Int J Cancer 2013 Apr 11;132(8):1911-7. Epub 2012 Oct 11.

Department of Epidemiology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA.

Current studies suggesting that smokeless tobacco use increases the risk of head and neck cancer are hampered by small numbers. Consequently, there remains uncertainty in the magnitude and significance of this risk. We examined the relationship between smokeless tobacco use and head and neck squamous cell carcinoma (HNSCC) in a population-based case-control study with 1,046 cases and 1,239 frequency-matched controls. Logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95% CI), adjusting for age, gender, race, education level, cigarette smoking, and alcohol consumption. A nonsignificant elevated association between having ever used smokeless tobacco and HNSCC risk (OR = 1.20, 95% CI: 0.67-2.16) was observed. Individuals who reported 10 or more years of smokeless tobacco use had a significantly elevated risk of HNSCC (OR = 4.06, 95% CI: 1.31-12.64), compared to never users. In an analysis restricted to never cigarette smokers, a statistically significant association was observed between ever use of smokeless tobacco and the risk of HNSCC (OR = 4.21, 95% CI: 1.01-17.57). These findings suggest that long-term use of smokeless tobacco increases the risk of HNSCC.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.27839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552089PMC
April 2013

Environmental tobacco smoke and the risk of pancreatic cancer among non-smokers: a meta-analysis.

Occup Environ Med 2012 Dec 26;69(12):853-7. Epub 2012 Jul 26.

Department of Epidemiology, Brown Public Health Program, Brown University, Box G-S121-2, Providence RI 02912, USA.

Background: Experimental studies have linked exposure to tobacco-specific nitrosamines with pancreatic carcinogenesis. A number of epidemiological studies have examined the association between environmental tobacco smoke (ETS) and risk of pancreatic cancer but they have not yet been jointly summarised.

Objectives: To investigate the association between exposure to ETS and risk of pancreatic cancer by systematically reviewing and synthesising the available evidence.

Methods: We conducted a comprehensive literature search using MEDLINE and EMBASE and manual searching of the reference lists of the relevant research reports and review articles to identify full texts and abstracts published through October 2011. We used the random-effects model to pool summary relative risks (RR) comparing the highest category of exposure to ETS to people who had never been exposed.

Results: Exposure to ETS during childhood was not associated with risk of pancreatic cancer (three prospective and two retrospective studies; summary RR 1.12; 95% CI 0.89 to 1.43). In addition, no association was found with exposure to ETS during adulthood at home (five prospective and three retrospective studies; summary RR 1.23; 95% CI 0.86 to 1.77) or at work (one prospective and two retrospective studies; summary RR 0.94; 95% CI 0.67 to 1.33).

Conclusions: This meta-analysis does not provide evidence for an association between exposure to ETS and risk of pancreatic cancer.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1136/oemed-2012-100844DOI Listing
December 2012

Reexamination of total fluid intake and bladder cancer in the Health Professionals Follow-up Study Cohort.

Am J Epidemiol 2012 Apr 21;175(7):696-705. Epub 2012 Feb 21.

Department of Epidemiology, Brown Public Health Program, Brown University, Providence, RI 02912, USA.

It has been hypothesized that high fluid intake may reduce contact time between carcinogens and bladder epithelium and consequently reduce carcinogenesis. Epidemiologic studies examining fluid intake and bladder cancer have been extremely inconsistent, ranging from strong inverse to strong positive associations. The authors reevaluated the association between fluid intake and bladder cancer among 47,909 participants in the prospective Health Professionals Follow-up Study over a period of 22 years. During follow-up (1986-2008), 823 incident bladder cancer cases were diagnosed. Information on fluid intake was collected by using the food frequency questionnaire at baseline and every 4 years thereafter. Cox proportional hazard regression analysis was used to adjust for risk factors for bladder cancer. Total fluid intake was inversely associated with bladder cancer when the analysis was based on the baseline diet (relative risk = 0.76, 95% confidence interval: 0.60, 0.97), comparing the highest total daily fluid intake quintile (>2,531 mL/day) with the lowest quintile (<1,290 mL/day) (P(trend) = 0.01). However, no association was detected when the analysis was based on recent diet or cumulative updated diet. The updated analysis for total fluid intake and bladder cancer was attenuated compared with the original findings from the first 10-year follow-up period.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/aje/kwr359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324431PMC
April 2012
-->