Publications by authors named "Jia Zhu"

465 Publications

Potential mechanism of oral baicalin treating psoriasis via suppressing Wnt signaling pathway and inhibiting Th17/IL-17 axis by activating PPARγ.

Phytother Res 2022 Jul 2. Epub 2022 Jul 2.

Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.

Psoriasis (PSO), an immune-mediated chronic inflammatory skin disease, has seriously affected the quality of patients' life. It is urgent to find effective medicines with lower costs and less side effects. Baicalin (HQG) is the main bioactive substance from Scutellaria baicalensis with effects of anti-inflammation and immunoregulation. Herein, we explored the effect of oral HQG treating PSO and its potential mechanism. Firstly, network pharmacology was used to predict that HQG may act on Estrogen, TNF-alpha (tumor necrosis factor, TNF), interleukin-17 (IL-17) signaling pathways and Th17 cell differentiation, especially the key targets including TNF, Proto-oncogene tyrosine-protein kinase Src, Peroxisome proliferator-activated receptor gamma and Matrix metalloproteinase-9. Imiquimod (IMQ)-induced mice were then used to study the effects of HQG treating PSO. HQG could significantly ameliorate the skin lesions, decrease the level of inflammatory factors and inhibit Th1/Th17 cell differentiation in IMQ-induced mice. Finally, transcriptome analysis of skin lesions integrated with the prediction of network pharmacology further demonstrated that the potential mechanism may be associated with suppressing Wnt signaling pathway and inhibiting Th17/IL-17 axis by activating PPARγ. In conclusion, this study suggested that HQG may be a promising agent for further studies in the search for therapeutic strategies to treat PSO in the future.
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http://dx.doi.org/10.1002/ptr.7546DOI Listing
July 2022

IDO1 plays a tumor-promoting role via MDM2-mediated suppression of the p53 pathway in diffuse large B-cell lymphoma.

Cell Death Dis 2022 Jun 27;13(6):572. Epub 2022 Jun 27.

Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong Province, China.

With the intensive therapeutic strategies, diffuse large B-cell lymphoma (DLBCL) is still a fatal disease due to its progressive characteristics. Indoleamine 2,3-dioxygenase 1 (IDO1) is a key regulator that catalyzes the commitment step of the kynurenine pathway in the immune system, its aberrant activation may contribute to malignant cell escape eradication. However, the role of IDO1 in DLBCL progression remains elusive. Our study showed IDO1 expression was upregulated in DLBCL and was associated with a poor prognosis and low overall survival. Inhibition of IDO1 suppressed DLBCL cell proliferation in vitro and impeded xenograft tumorigenesis in vivo. RNA-seq analyses revealed MDM2 was downregulated while TP53 was upregulated in IDO1 inhibition OCI-Ly10 cells. Mechanistically, IDO1 inhibition decreased the expression of MDM2, a major negative regulator of p53, and restored p53 expression in OCI-Ly3 and OCI-Ly10 cells, resulting in cell cycle arrest and apoptosis. IDO1 inhibition induced cell apoptosis coupled with PUMA and BAX upregulation, as well as BCL2 and BCL-XL downregulation. In addition, p21, a p53 transcriptional target, was upregulated in cell cycle arrest. Taken together, this study revealed IDO1 is essential for the proliferation of DLBCL cells and may be a potential therapeutic target for the treatment of DLBCL.
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http://dx.doi.org/10.1038/s41419-022-05021-2DOI Listing
June 2022

Immune-Related LncRNAs as Prognostic Factors for Pediatric Rhabdoid Tumor of the Kidney.

Dis Markers 2022 15;2022:4752184. Epub 2022 Jun 15.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.

Background: Immune-related long noncoding RNAs (IrlncRNAs) are recognized as important prognostic factors in a variety of cancers, but thus far, their prognostic value in pediatric rhabdoid tumor of the kidney (pRTK) has not been reported. Here, we clarified the associations between IrlncRNAs and overall survival (OS) of pRTK patients and constructed a model to predict their prognosis.

Methods: We accessed RNA sequencing data and corresponding clinical data of pRTK from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database. An expression profile of immune-related genes (Irgenes) and lncRNAs of pRTK was extracted from the RNA sequencing data. IrlncRNAs were defined by co-expression analysis of lncRNAs and Irgenes. The limma R package was used to identify differential expression IrlncRNAs. Univariate and multivariate Cox regression analyses were conducted to build a prognostic IrlncRNAs model. The performance of this prognostic model was validated by multimethods, like ROC curve analysis.

Results: A total of 1097 IrlncRNAs were defined. Univariate Cox regression analysis identified 7 IrlncRNAs (AC004791.2, AP003068.23, RP11-54O7.14, RP11-680F8.1, TBC1D3P1-DHX40P1, TUNAR, and XXbac-BPG308K3.5) and were significantly associated with OS. Multivariate regression analysis constructed the best prognostic model based on the expression of AC004791.2, AP003068.23, RP11-54O7.14, TBC1D3P1-DHX40P1, and TUNAR. According to the prognostic model, a risk score of each patient was calculated, and patients were divided into high-risk and low-risk groups accordingly. The survival time of low-risk patients was significantly better than high-risk patients ( < 0.001). Univariate (hazard ratio 1.098, 95% confidence interval 1.048-1.149, value <0.001) and multivariate (hazard ratio 1.095, 95% confidence interval 1.043-1.150, value <0.001) analyses confirmed that the prognostic model was reliable and independent in prediction of OS. Time-dependent ROC analysis showed that 1-year survival AUC of prognostic model, stage, age, and sex was 0.824, 0.673, 0.531, and 0.495, respectively, which suggested that the prognostic model was the best predictor of survival in pRTK patients.

Conclusions: The prognostic model based on 5 IrlncRNAs was robust and could better predict the survival of pRTK than other clinical factors. Additionally, the mechanism of regulation and action of prognosis-associated lncRNAs could provide new avenues for basic research to explore the mechanism of tumor initiation and development in order to prevent and treat pRTK.
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http://dx.doi.org/10.1155/2022/4752184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217527PMC
June 2022

Potential shared therapeutic and hepatotoxic mechanisms of Tripterygium wilfordii polyglycosides treating three kinds of autoimmune skin diseases by regulating IL-17 signaling pathway and Th17 cell differentiation.

J Ethnopharmacol 2022 Jun 21;296:115496. Epub 2022 Jun 21.

Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China. Electronic address:

Ethnopharmacological Relevance: Tripterygium wilfordii polyglycosides (TWP) are extracted from Tripterygium wilfordii Hook. f., which has the significant effects of anti-inflammation and immunosuppression and has been widely used to treat autoimmune diseases in traditional Chinese medicine.

Aim Of Study: In Chinese clinical dermatology, TWP was generally used for the treatment of autoimmune skin diseases including psoriasis (PSO), systemic lupus erythematosus (SLE) and pemphigus (PEM). However, the potential hepatotoxicity (HPT) induced by TWP was also existing with the long-term use of TWP. This study aims to explore the potential shared therapeutic mechanism of TWP treating PSO, SLE, PEM and the possible hepatotoxic mechanism induced by TWP.

Materials And Methods: Network pharmacology was used to predict the potential targets and pathways in this study. The main bioactive compounds in TWP was screened according to TCMSP, PubChem, ChEMBL databases and Lipinski's Rule of Five. The potential targets of these chemical constituents were obtained from PharmMapper, SEA and SIB databases. The related targets of PSO, SLE, PEM and HPT were collected from GeneCards, DrugBank, DisGeNET and CTD databases. The target network construction was performed through STRING database and Cytoscape. GO enrichment, KEGG enrichment and molecular docking were then performed, respectively. In particular, imiquimod (IMQ)-induced PSO model was selected as the representative for the experimental verification of effects and shared therapeutic mechanisms of TWP.

Results: 41 targets were considered as the potential shared targets of TWP treating PSO, SLE and PEM. KEGG enrichment indicated that IL-17 signaling pathway and Th17 cell differentiation were significant in the potential shared therapeutic mechanism of TWP. The animal experimental verification demonstrated that TWP could notably ameliorate skin lesions (P˂0.001), decrease inflammatory response (P˂0.05, P˂0.01, P˂0.001) and inhibit the differentiation of Th1/Th17 cells (P˂0.05, P˂0.01) compared to PSO model group. The molecular docking and qPCR validation then showed that TWP could effectively act on MAPK14, IL-2, IL-6 and suppress Th17 cell differentiation and IL-17 signaling pathway. The possible hepatotoxic mechanism of TWP indicated that there were 145 hepatotoxic targets and it was also associated with IL-17 signaling pathway and Th17 cell differentiation, especially for the key role of ALB, CASP3 and HSP90AA1. Meanwhile, the potential correlations between efficacy and hepatotoxicity of TWP showed that 28 targets were shared by therapeutic and hepatotoxic mechanisms such as IL-6, IL-2, MAPK14, MMP9, ALB, CASP3 and HSP90AA1. These significant relevant targets were also involved in IL-17 signaling pathway and Th17 cell differentiation.

Conclusions: There were shared disease targets in PSO, SLE and PEM, and TWP could treat them by potential shared therapeutic mechanisms of suppressing IL-17 signaling pathway and Th17 cell differentiation. The possible hepatotoxicity induced by TWP was also significantly associated with the regulation of IL-17 signaling pathway and Th17 cell differentiation. Meanwhile, the potential correlations between efficacy and hepatotoxicity of TWP also mainly focused on IL-17 signaling pathway and Th17 cell differentiation, which provided a potential direction for the study of the mechanism of "You Gu Wu Yun" theory of TWP treating autoimmune skin diseases in the future.
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http://dx.doi.org/10.1016/j.jep.2022.115496DOI Listing
June 2022

The relationship between relative telomere length and anti-tuberculosis drug-induced hepatitis : A case-control study.

Therapie 2022 May 25. Epub 2022 May 25.

Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, 211166 Nanjing, China. Electronic address:

Aim: Anti-tuberculosis drug-induced hepatitis (AT-DIH) is a common and serious adverse drug reaction of tuberculosis treatment. Evidence demonstrated that many factors could affect the occurrence of AT-DIH, such as ageing, smoking, alcohol, oxidative stress, etc., while these factors could also promote telomere shortening. Therefore, relative telomere length (RTL) is indirectly related to the occurrence of AT-DIH. The present study aimed to explore and validate this relationship in Chinese tuberculosis patients.

Methods: A 1:4 matched case-control study was undertaken using 202 AT-DIH cases and 808 controls. Logistic regression models were used to estimate the association between RTL and AT-DIH with odds ratios (ORs) and 95% confidence intervals (CIs). The area under receiver operating characteristic curve (AUC) was calculated to estimate the discriminative performance for distinguishing AT-DIH cases from controls.

Results: The average RTL in AT-DIH cases was significantly shorter than that in controls (1.24 vs. 1.46, P=0.002). Patients with longer RTL were at a reduced risk of AT-DIH (OR=0.79, 95% CI: 0.66-0.94, P=0.009), and a dose-response relationship also existed between RTL and lower AT-DIH risk (P for trend=0.012). Under the optimal RTL cut-off value of 1.22, the corresponding AUCs were 0.57 (95% CI: 0.53-0.62, P=0.001) in the univariate model and 0.62 (95% CI: 0.57-0.66, P<0.001) in the multivariate model.

Conclusion: This study showed that the shorter the RTL, the higher the risk of AT-DIH during an anti-tuberculosis treatment. The short RTL could potentially serve as a risk factor or a predictive test of the hepatotoxic risk associated with anti-tuberculosis treatments.
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http://dx.doi.org/10.1016/j.therap.2022.05.007DOI Listing
May 2022

[Impacts of Changes in Meteorological Conditions During COVID-19 Lockdown on PM Concentrations over the Jing-Jin-Ji Region].

Huan Jing Ke Xue 2022 Jun;43(6):2831-2839

Tianjin Environmental Meteorology Center, Tianjin 300074, China.

The Chinese government triggered the immediate implementation of a lockdown policy in China following the outbreak of the COVID-19 pandemic, leading to drastic decreases in air pollutant emissions. However, concentrations of PM and other pollutants increased during the COVID-19 lockdown over the Jing-Jin-Ji region compared with those averaged over 2015-2019, and two PM pollution events occurred during the lockdown. Using the ERA5 reanalysis data, we found that the Jing-Jin-Ji region during the COVID-19 lockdown was characterized by higher relative humidity, lower planetary boundary layer height, and anomalous updraft. These conditions were favorable for condensation and the secondary formation of aerosols and prevented turbulent diffusion of pollutants. Furthermore, we conducted sensitivity tests using the WRF-Chem model and found that (PM) increased by 20-55 μg·m(60%-170%) over the middle region of Jing-Jin-Ji during the COVID-19 lockdown due to changes in meteorological conditions. Furthermore, the enhanced aerosol chemistry and unfavorable diffusion conditions were identified as the key factors driving increases in PM concentrations during the lockdown. Planetary boundary layer height and relative humidity may become the important factors in forecasting PM pollution events over the Jing-Jin-Ji region under the background of emission reduction.
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http://dx.doi.org/10.13227/j.hjkx.202109233DOI Listing
June 2022

Synthesis of Holmium-Oxide Nanoparticles for Near-Infrared Imaging and Dye-Photodegradation.

Molecules 2022 May 30;27(11). Epub 2022 May 30.

Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, School of Electrical and Automation Engineering, Nanjing Normal University, Nanjing 210046, China.

The development of multifunctional nanomaterials has received growing research interest, thanks to its ability to combine multiple properties for severing highly demanding purposes. In this work, holmium oxide nanoparticles are synthesized and characterized by various tools including XRD, XPS, and TEM. These nanoparticles are found to emit near-infrared fluorescence (800-1100 nm) under a 785 nm excitation source. Imaging of the animal tissues was demonstrated, and the maximum imaging depth was found to be 2.2 cm. The synthesized nanoparticles also show the capability of facilitating dye (fluorescein sodium salt and rhodamine 6G) degradation under white light irradiation. The synthesized holmium oxide nanoparticles are envisioned to be useful for near-infrared tissue imaging and dye-degradation.
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http://dx.doi.org/10.3390/molecules27113522DOI Listing
May 2022

Molecular-Level Insights into Unique Behavior of Water Molecules Confined in the Heterojunction between One- and Two-Dimensional Nanochannels.

Langmuir 2022 Jun 30;38(23):7300-7311. Epub 2022 May 30.

Institute of Advanced Materials (IAM), State-Province Joint Engineering Laboratory of Zeolite Membrane Materials, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, People's Republic of China.

With the increasing importance of nanoconfined water in various heterostructures, it is quite essential to clarify the influence of nanoconfinement on the unique properties of water molecules in the pivotal heterojunction. In this work, we reported a series of classical molecular dynamics (MD) simulations to explore nanoconfined water in the subnanometer-sized and nanometer-sized heterostructures by adjusting one-dimensional (1-D) carbon nanotubes with different diameters and two-dimensional (2-D) graphene sheets with different interlayer distances. Our simulation results demonstrated that water molecules in the 1-D/2-D heterojunction show an obvious structural rearrangement associated with the remarkable breaking and formation of hydrogen bonds (HBs), and such rearrangements in the subnanometer-sized systems are much more pronounced than those in the nanometer-sized ones. When water molecules in the 1-D/2-D heterojunctions migrate from 2-D to 1-D confinements, the ordered multi-layer structure in the 2-D confinement are completely destroyed and then transform into different circular HB networks near the nanotube orifice for better connecting to the single-file or helical HB network in the 1-D nanotubes. Furthermore, water molecules in the 1-D/2-D heterojunctions can form stronger HBs with those water molecules further away from the 1-D confinement, leading to an asymmetrical orientational distribution near the orifice. More importantly, our comparison results revealed that the 1-D confinement plays a more important role than the 2-D confinement in determining both the structures and dynamics of water molecules in the 1-D/2-D heterojunction.
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http://dx.doi.org/10.1021/acs.langmuir.2c00825DOI Listing
June 2022

Investigation of Whole and Glandular Saliva as a Biomarker for Alzheimer's Disease Diagnosis.

Brain Sci 2022 May 3;12(5). Epub 2022 May 3.

Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.

Salivary Aβ40, Aβ42, t-tau, and -tau 181 are commonly employed in Alzheimer's disease (AD) investigations. However, the collection method of these biomarkers can affect their levels. To assess the impact of saliva collection methods on biomarkers in this study, 15 healthy people were employed in the morning with six saliva collection methods. The chosen methods were then applied in 30 AD patients and 30 non-AD controls. The levels of salivary biomarkers were calculated by a specific enzyme-linked immunosorbent assay. The receiver operating characteristic was utilized to assess salivary biomarkers in AD patients. The results demonstrated that the highest levels of salivary Aβ40, Aβ42, t-tau, and -tau were in different saliva collection methods. The correlations between different saliva biomarkers in the same collection method were different. Salivary Aβ40, Aβ42, t-tau, and -tau had no significant association. Salivary Aβ42 was higher in AD than in non-AD controls. However, -tau/t-tau and Aβ42/Aβ40 had some relevance. The area under the curve for four biomarkers combined in AD diagnosis was 92.11%. An alternate saliva collection method (e.g., USS in Aβ40, UPS in Aβ42, t-tau, SSS in -tau 181) was demonstrated in this study. Moreover, combining numerous biomarkers improves AD diagnosis.
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http://dx.doi.org/10.3390/brainsci12050595DOI Listing
May 2022

High-yield solar-driven atmospheric water harvesting of metal-organic-framework-derived nanoporous carbon with fast-diffusion water channels.

Nat Nanotechnol 2022 May 26. Epub 2022 May 26.

National Laboratory of Solid State Microstructures, College of Engineering and Applied Sciences, Jiangsu Key Laboratory of Artificial Functional Materials and Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing, People's Republic of China.

Solar-driven, sorption-based atmospheric water harvesting (AWH) offers a cost-effective solution to freshwater scarcity in arid areas. Creating AWH devices capable of performing multiple adsorption-desorption cycles per day is crucial for increasing water production rates matching human water requirements. However, achieving rapid-cycling AWH in passive harvesters has been challenging due to sorbents' slow water adsorption-desorption dynamics. Here we report an MOF-derived nanoporous carbon, a sorbent endowed with fast sorption kinetics and excellent photothermal properties, for high-yield AWH. The optimized structure (40% adsorption sites and ~1.0 nm pore size) has superior sorption kinetics due to the minimized diffusion resistance. Moreover, the carbonaceous sorbent exhibits fast desorption kinetics enabled by efficient solar-thermal heating and high thermal conductivity. A rapid-cycling water harvester based on nanoporous carbon derived from metal-organic frameworks can produce 0.18 L kg h of water at 30% relative humidity under one-sun illumination. The proposed design strategy is helpful to develop high-yield, solar-driven AWH for advanced freshwater-generation systems.
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http://dx.doi.org/10.1038/s41565-022-01135-yDOI Listing
May 2022

Smart bioadhesives for wound healing and closure.

Bioact Mater 2023 Jan 26;19:360-375. Epub 2022 Apr 26.

Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, 16802, USA.

The high demand for rapid wound healing has spurred the development of multifunctional and smart bioadhesives with strong bioadhesion, antibacterial effect, real-time sensing, wireless communication, and on-demand treatment capabilities. Bioadhesives with bio-inspired structures and chemicals have shown unprecedented adhesion strengths, as well as tunable optical, electrical, and bio-dissolvable properties. Accelerated wound healing has been achieved via directly released antibacterial and growth factors, material or drug-induced host immune responses, and delivery of curative cells. Most recently, the integration of biosensing and treatment modules with wireless units in a closed-loop system yielded smart bioadhesives, allowing real-time sensing of the physiological conditions (e.g., pH, temperature, uric acid, glucose, and cytokine) with iterative feedback for drastically enhanced, stage-specific wound healing by triggering drug delivery and treatment to avoid infection or prolonged inflammation. Despite rapid advances in the burgeoning field, challenges still exist in the design and fabrication of integrated systems, particularly for chronic wounds, presenting significant opportunities for the future development of next-generation smart materials and systems.
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http://dx.doi.org/10.1016/j.bioactmat.2022.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062426PMC
January 2023

Multi-Platform Omics Analysis Reveals Molecular Signatures for Pathogenesis and Activity of Systemic Lupus Erythematosus.

Front Immunol 2022 19;13:833699. Epub 2022 Apr 19.

Department of Otolaryngology, Head and Neck Surgery, Children's Hospital Affiliated Capital Institute of Pediatrics, Beijing, China.

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with heterogeneous clinical manifestations and the pathogenesis of SLE is still unclear. Various omics results have been reported for SLE, but the molecular hallmarks of SLE, especially in patients with different disease activity, using an integrated multi-omics approach have not been fully investigated. Here, we collected blood samples from 10 healthy controls (HCs) and 40 SLE patients with different clinical activity including inactive (IA), low activity (LA), and high activity (HA). Using an integrative analysis of proteomic, metabolomic and lipidomic profiles, we report the multi-omics landscape for SLE. The molecular changes suggest that both the complement system and the inflammatory response were activated in SLEs and were associated with disease activity. Additionally, activation of the immunoglobulin mediated immune response were observed in the LA stage of the disease, however this immune response was suppressed slightly in the HA stage. Finally, an imbalance in lipid metabolism, especially in sphingolipid metabolism, accompanied with dysregulated apolipoproteins were observed to contribute to the disease activity of SLE. The multi-omics data presented in this study and the characterization of peripheral blood from SLE patients may thus help provide important clues regarding the pathogenesis of SLE.
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http://dx.doi.org/10.3389/fimmu.2022.833699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063006PMC
April 2022

Prognostic role of SPRY4-IT1 in female breast carcinoma and malignant tumors of the reproductive system: A meta-analysis.

Medicine (Baltimore) 2022 Apr 22;101(16):e28969. Epub 2022 Apr 22.

Hebei General Hospital, Shijiazhuang, Hebei, PR China.

Background: The prognostic value of SPRY4-Intronic transcript 1 (SPRY4-IT1) in women suffering from breast carcinoma and malignant tumors of the reproductive system remains to be ascertained. Therefore, this paper attempted to assess the relationship between SPRY4-IT1 with the clinicopathological indicators and survival analysis in women suffering from breast carcinoma and malignant tumors of their reproductive organs through meta-analysis.

Method: Related literature retrieved from Cochrane Library, Ovid, Embase, PubMed, the CNKI, and the Web of Science databases were reviewed. The latest article search was updated to September 1, 2021. The outcome indicators included as effective measures in the study were hazard ratio (HR), odds ratio (OR), and 95% confidence interval (CI). The Stata 12.0 software was used to analyze the data.

Results: The elevated SPRY4-IT1 levels were indicative of poor overall survival (OS) [HR = 2.44, 95% CI = 1.35-4.43, P < .05], and were not related to Disease-Free Survival (DFS) [HR = 1.61, 95% CI = 0.50-5.18, P = .43] in female patients suffering from malignant tumors. In terms of lymph node metastasis (LNM) for the association between long noncoding RNA SPRY4-IT1(LncRNA SPRY4-IT1) and OS, elevated LncRNA SPRY4-IT1 implied poor OS with LNM [HR = 2.79, 95% CI: 1.81-4.28, P < .001]. Based on the aspect of the LNM for the association between LncRNA SPRY4-IT1 and DFS, SPRY4-IT1 was not correlated with DFS [HR = 0.97, 95% CI: 0.73-1.28, P = .81]. SPRY4-IT1 in the TNM stage was not related to OS [HR = 1.43, 95% CI: 0.55-3.70, P = .46]. In the TNM stage, SPRY4-IT1 was not related to DFS [HR = 1.68, 95% CI: 0.92-3.06, P = .09]. SPRY4-IT1 was found to be associated with lymph node metastasis (OR = 4.15, 95% CI: 2.75-6.25, P = .000) and TNM stage (OR = 2.89, 95% CI: 1.51-7.27 P = .02). No significant correlation was noted between SPRY4-IT1 and the age of the patients (OR = 0.89, 95% CI: 0.61-1.29 P = .54).

Conclusions: Thus, this study provides evidence-based medical evidence for the target treatment of female breast carcinoma and malignant tumors of the reproductive system. The elevated level of SPRY4-IT1 was associated with poor prognosis of female breast cancer patients and of those having malignant tumors in their reproductive organs. In addition, the SPRY4-IT1 expression was also associated with the disease progression and metastasis.
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http://dx.doi.org/10.1097/MD.0000000000028969DOI Listing
April 2022

Heme oxygenase-1 and hemopexin gene polymorphisms and the risk of anti-tuberculosis drug-induced hepatotoxicity in China.

Pharmacogenomics 2022 May 26;23(7):431-441. Epub 2022 Apr 26.

Department of Epidemiology & Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.

To assess whether the risk of anti-tuberculosis drug-induced hepatotoxicity (ATDH) might be influenced by heme oxygenase-1 () and hemopexin () gene polymorphisms. A dynamic anti-tuberculosis treatment cohort was constructed, and the 1:4 matched nested case-control study was analysed. Eight single-nucleotide polymorphisms (SNPs) of the two genes were selected for genotyping and Bonferroni correction was performed to correct for multiple comparison. Overall, 7.8% of patients developed ATDH. SNP rs1807714 in the gene had decreased effects on the risk of moderate and severe hepatotoxicity under the dominant and additive models, and hepatocellular injury under the additive model. SNP rs2682099 in the gene had increased effects on the risk of moderate and severe hepatotoxicity under the recessive model. However, these associations disappeared after Bonferroni correction. and gene polymorphisms might not be associated with susceptibility to ATDH in the Chinese population.
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http://dx.doi.org/10.2217/pgs-2022-0015DOI Listing
May 2022

The role of the genetic variant FECH rs11660001 in the occurrence of anti-tuberculosis drug-induced liver injury.

J Clin Pharm Ther 2022 Apr 25. Epub 2022 Apr 25.

Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.

What Is Known And Objective: The pathogenic mechanism of anti-tuberculosis drug-induced liver injury (AT-DILI) is still largely unknown. Recent studies have indicated that rifampicin and isoniazid cotreatment causes the accumulation of endogenous protoporphyrin IX in the liver through the haem biosynthesis pathway. Alanine synthase 1 (ALAS1) and ferrochelatase (FECH) are the rate-limiting enzymes in the production of haem. The present study aimed to investigate the genetic contribution of the ALAS1 and FECH genes to the risk of AT-DILI in an Eastern Chinese Han population.

Methods: A 1:4 matched case-control study was conducted, and eight SNPs in the ALAS1 and FECH genes were detected and assessed. A multivariate conditional logistic regression model was used to estimate the association between genotypes and the risk of AT-DILI by the odds ratios (ORs) with 95% confidence intervals (CIs), with liver disease history, hepatoprotectant use, smoking and drinking history as covariates.

Results And Discussion: Overall, 202 AT-DILI cases and 808 controls were included in this study. The female patients carrying polymorphisms of rs11660001 in FECH had an increased risk of AT-DILI under the dominant and additive models (OR = 1.831, 95% CI: 1.014-3.307, p = 0.045; OR = 1.673, 95% CI: 1.015-2.760, p = 0.044, respectively). The peak aspartate transaminase level was significantly higher in female patients carrying the GA+AA genotype of rs11660001 than in those with the GG genotype during anti-TB treatment (p = 0.032).

What Is New And Conclusion: Based on this 1:4 individual matched case-control study, SNP rs11660001 in the FECH gene may be associated with susceptibility to AT-DILI in Chinese female anti-TB treatment patients. Further studies in larger varied populations are needed to validate our findings.
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http://dx.doi.org/10.1111/jcpt.13672DOI Listing
April 2022

HSV-2-Specific Human Female Reproductive Tract Tissue Resident Memory T Cells Recognize Diverse HSV Antigens.

Front Immunol 2022 31;13:867962. Epub 2022 Mar 31.

Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, United States.

Antigen-specific T persist and protect against skin or female reproductive tract (FRT) HSV infection. As the pathogenesis of HSV differs between humans and model organisms, we focus on humans with well-characterized recurrent genital HSV-2 infection. Human CD8+ T persisting at sites of healed human HSV-2 lesions have an activated phenotype but it is unclear if T can be cultivated . We recovered HSV-specific T from genital skin and ectocervix biopsies, obtained after recovery from recurrent genital HSV-2, using activation by viral antigen. Up to several percent of local T cells were HSV-reactive CD4 and CD8 T cell lines were up to 50% HSV-2-specific after sorting-based enrichment. CD8 T displayed HLA-restricted reactivity to specific HSV-2 peptides with high functional avidities. Reactivity to defined peptides persisted locally over several month and was quite subject-specific. CD4 T derived from biopsies, and from an extended set of cervical cytobrush specimens, also recognized diverse HSV-2 antigens and peptides. Overall we found that HSV-2-specific T are abundant in the FRT between episodes of recurrent genital herpes and maintain competency for expansion. Mucosal sites are accessible for clinical monitoring during immune interventions such as therapeutic vaccination.
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http://dx.doi.org/10.3389/fimmu.2022.867962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9009524PMC
April 2022

The Efficacy and Safety of Anlotinib in Pediatric Patients With Refractory or Recurrent Solid Tumors.

Front Pharmacol 2022 31;13:711704. Epub 2022 Mar 31.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

Refractory or recurrent pediatric solid tumors lack effective treatments, and are associated with dismal outcomes. Hence, there is an urgent need for a novel therapeutic strategy. This study aimed to evaluate the efficacy and safety of anlotinib, a novel oral multi-kinase angiogenesis inhibitor, in pediatric patients with refractory or recurrent solid tumors. This single-institutional, observational retrospective study was conducted in Sun Yat-sen University Cancer Center, China. Refractory or recurrent pediatric solid tumor patients treated with anlotinib between 2018 and 2020 were evaluated. Forty-one and 30 patients were enrolled to evaluate the efficacy and safety of anlotinib, respectively. There was partial response in five patients, stable disease in 22 patients, no patient with complete response, with an objective response ratio of 12.2% (5/41; 95% CI 1.7-22.7). The disease control rate was 65.9% (27/41; 95% CI 50.7-81) and the median progression-free survival was 2.87 months (95% CI 0.86-4.88). The incidence rates of any grade and grade 3-4 adverse events were 80% (24/30) and 23.3% (7/30), respectively. Bleeding (20%, 6/30), hand-foot syndrome (16.7%, 5/30), and diarrhea (13.3%, 4/30) were the most common adverse events. Grade 3-4 adverse events included hypertension, hand-foot syndrome, diarrhea, anemia, and thrombocytopenia. There were no adverse events-related deaths. For heavily pretreated pediatric solid tumors, anlotinib monotherapy and its combination with chemotherapy may be an effective treatment option with tolerable adverse events. It is necessary to monitor blood pressure when using anlotinib in children.
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http://dx.doi.org/10.3389/fphar.2022.711704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008584PMC
March 2022

KDM5B promotes tumorigenesis of Ewing sarcoma via FBXW7/CCNE1 axis.

Cell Death Dis 2022 Apr 15;13(4):354. Epub 2022 Apr 15.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, PR China.

Ewing sarcoma (EwS) is an aggressive tumor that affects children and young adults. Patients with relapsed/refractory diseases have limited treatment options. Targeting the driver fusion oncoproteins of EwS remains a technical problem. Epigenetic mechanisms have been pointed out as key players and alternative therapeutic targets in EwS. Here, we reported that lysine demethylase 5B (KDM5B), a histone demethylase that specifically demethylates tri- and di-methylated H3 Lys-4 (H3K4), was upregulated in EwS and overexpressed KDM5B was correlated with poor outcomes of patients. KDM5B knockdown and KDM5B inhibitor AS-8351 suppressed EwS cell proliferation and induced cell cycle arrest. Bioinformatics analysis revealed that KDM5B mainly influenced the cell cycle pathways in EwS. In mechanistic studies, we found that overexpression of KDM5B resulted in increased CCNE1 protein level, but did not affect the mRNA level of CCNE1. KDM5B upregulation blocked the degradation pathway of CCNE1 by reducing the expression of FBXW7. KDM5B downregulated FBXW7 gene by demethylation of H3K4me3 at promoter region. Moreover, AS-8351 could inhibit tumor growth in nude mice models, indicating the antitumor effect of targeting KDM5B in EwS. Our study uncovered that KDM5B in EwS attenuated FBXW7 transcription and accumulated CCNE1 protein, leading to malignant proliferation of EwS. Epigenetic drug targeting KDM5B could be a potential treatment for EwS.
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http://dx.doi.org/10.1038/s41419-022-04800-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012801PMC
April 2022

Decreased gene expression of K and K channels in hyperthyroid rabbit atria.

Int J Clin Exp Pathol 2022 15;15(3):145-151. Epub 2022 Mar 15.

School of Basic Medical Sciences, The Second Affiliated Hospital of Shandong First Medical University & Shandong Academy of Medical Science Jinan 250117, Shandong, China.

Cardiac hypertrophy is a common myocardial structural abnormality which may cause heart failure. Many studies have shown that cardiac hypertrophy can be induced by hyperthyroidism. Ligand-gated potassium channels have been reported to be involved in various biological processes in the cardiovascular system, such as GPCR coupled K and metabolism sensor K channel. It is unclear whether the gene expression of K and K was altered in hyperthyroid rabbit atria. We aimed to investigate the expression of K and K genes in rabbit atria in our experimental model. We established an effective hyperthyroidism-induced cardiac hypertrophy animal model through an injection of T4. H&E staining and RT-PCR were used to observe the histomorphological damages and alteration of gene expression. The results showed that the heart weight, heart rate significantly increased in T4-treated rabbits. The systolic pressure increased from 115.60 mmHg to 152.6 mmHg in T4-treated rabbits. The expression of K and K genes was decreased in the atria of hyperthyroidism-induced cardiac hypertrophied rabbits. These findings indicated that the decreased gene expression of K and K may be related to hyperthyroidism-induced cardiac hypertrophy and atrial fibrillation.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986473PMC
March 2022

Correlations of Salivary and Blood Glucose Levels among Six Saliva Collection Methods.

Int J Environ Res Public Health 2022 03 30;19(7). Epub 2022 Mar 30.

Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.

Background: Saliva has been studied as a better indicator of disorders and diseases than blood. Specifically, the salivary glucose level is considered to be an indicator of diabetes mellitus (DM). However, saliva collection methods can affect the salivary glucose level, thereby affecting the correlation between salivary glucose and blood glucose. Therefore, this study aims to identify an ideal saliva collection method and to use this method to determine the population and individual correlations between salivary glucose and blood glucose levels in DM patients and healthy controls. Finally, an analysis of the stability of the individual correlations is conducted.

Methods: This study included 40 age-matched DM patients and 40 healthy controls. In the fasting state, saliva was collected using six saliva collection methods, venous blood was collected simultaneously from each study participant, and both samples were analyzed at the same time using glucose oxidase peroxidase. A total of 20 DM patients and 20 healthy controls were arbitrarily selected from the above participants for one week of daily testing. The correlations between salivary glucose and blood glucose before and after breakfast were analyzed. Finally, 10 DM patients and 10 healthy controls were arbitrarily selected for one month of daily testing to analyze the stability of individual correlations.

Results: Salivary glucose levels were higher in DM patients than healthy controls for the six saliva collection methods. Compared with unstimulated saliva, stimulated saliva had decreased glucose level and increased salivary flow. In addition, unstimulated parotid salivary glucose was most correlated with blood glucose level (R = 0.9153), and the ROC curve area was 0.9316, which could accurately distinguish DM patients. Finally, it was found that the correlations between salivary glucose and blood glucose in different DM patients were quite different. The average correlation before breakfast was 0.83, and the average correlation after breakfast was 0.77. The coefficient of variation of the correlation coefficient before breakfast within 1 month was less than 5%.

Conclusion: Unstimulated parotid salivary glucose level is the highest and is most correlated with blood glucose level, which can be accurately used to distinguish DM patients. Meanwhile, the correlation between salivary glucose and blood glucose was found to be relatively high and stable before breakfast. In general, the unstimulated parotid salivary glucose before breakfast presents an ideal saliva collecting method with which to replace blood-glucose use to detect DM, which provides a reference for the prediction of DM.
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http://dx.doi.org/10.3390/ijerph19074122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8999001PMC
March 2022

Meteorological influences on daily variation and trend of summertime surface ozone over years of 2015-2020: Quantification for cities in the Yangtze River Delta.

Sci Total Environ 2022 Aug 6;834:155107. Epub 2022 Apr 6.

Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, Jiangsu Engineering Technology Research Center of Environmental Cleaning Materials, Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, School of Environmental Science and Engineering, Nanjing University of Information Science & Technology, Nanjing, Jiangsu, China.

We quantify the meteorological influences on daily variations and trends of maximum daily 8-h average ozone (MDA8 O) concentrations by using multiple linear regression (MLR) and Lindeman, Merenda, and Gold (LMG) approaches. Different from previous region-based studies, we pay special attention to meteorological influences at city scale. Over 2015-2019, daily changes in key meteorological parameters could explain 47%-74% of the observed daily variations in summertime MDA8 O concentrations in Yangtze River Delta (YRD) and four cities (Shanghai, Nanjing, Hangzhou, and Hefei), with RH being the top driver. Over years of 2015-2020, daily concentrations of MDA8 O obtained from MLR equations (MDA8O_MLR) of the local cities always had better performance than those of YRD. Compared with the observed daily MDA8 O in June-July-August (JJA) over the studied period, daily MDA8O_MLR of the local cities (of YRD) had correlation coefficients of 0.73 (0.63), 0.75 (0.74), 0.79 (0.78), and 0.76 (0.73) in Shanghai, Nanjing, Hangzhou, and Hefei, respectively, and the MDA8O_MLR of the local cities (of YRD) captured 54% (17%), 63% (51%), 52% (27%) of the observed O-polluted days (days with MDA8 O concentration exceeding 160 μg m) in Shanghai, Nanjing, and Hangzhou, respectively. The meteorologically driven trends (Trend_Met) in MDA8 O were calculated using the established MLR equations. Over 2015-2019, the observed trends (Trend_Obs) and Trend_Met in MDA8 O were mostly positive in YRD, Nanjing, Hangzhou, and Hefei. In Shanghai, Trend_Obs, Trend_Met, and anthropogenically driven trend (estimated as Trend_Obs minus Trend_Met) of MDA8 O in JJA over 2015-2019 were -1.3, +1.0, and -2.3 μg m y, respectively, indicating that the emission control measures alleviated O pollution in this city. Our results suggest that it is necessary to establish MLR equations at city scale to account for the role of meteorology in the actions of O pollution control.
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http://dx.doi.org/10.1016/j.scitotenv.2022.155107DOI Listing
August 2022

Correction: Chemical structure modulation in conductive MOFs by adjusting the oxidation state of the ligand and introducing alkali metal ions.

Chem Commun (Camb) 2022 Apr 14;58(31):4917. Epub 2022 Apr 14.

Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Organic Solids, Institute of Chemistry Chinese Academy of Sciences, Beijing 100190, China.

Correction for 'Chemical structure modulation in conductive MOFs by adjusting the oxidation state of the ligand and introducing alkali metal ions' by Xiaoyu Wu , , 2022, , 2702-2705, DOI: 10.1039/D1CC06407J.
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http://dx.doi.org/10.1039/d2cc90115cDOI Listing
April 2022

Vincristine, Irinotecan, and Temozolomide in Patients With Relapsed/Refractory Neuroblastoma.

Front Oncol 2022 9;12:804310. Epub 2022 Mar 9.

Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Guangzhou, China.

Purpose: The combination of irinotecan, temozolomide and vincristine has been proposed as an effective salvage regimen for some pediatric malignancies. Thus, we sought to evaluate this combination for patients with relapsed and refractory neuroblastoma (NB).

Patients And Methods: In this retrospective study, forty-six patients with relapsed or refractory NB were treated with the combination of vincristine (1.5 mg/m i.v. day 1), irinotecan (50 mg/m/day i.v. days 1-5) and temozolomide (100 mg/m/day p.o. days 1-5) (VIT) during the period 2011-2019. All toxicities were documented.

Results: A total of 251 cycles (median 6 cycles/patient) were administered. A complete response (CR) was achieved in 5 patients, partial response (PR) in 27 patients, stable disease (SD) in 8 patients, and progression disease (PD) in 6 patients, with an overall objective response rate (CR+PR) of 69.6%. Eighteen patients developed diarrhea with Grade 3 or less. Grade 1-2 hematologic toxicity occurred in 10 patients. Grade 3-4 hematologic toxicity developed in 32 patients. VIT was an effective regimen for different metastatic sites. UGT1A*28 genotyping performed in 7 patients revealed wild type. Diarrhea occurred in 4 of them.

Conclusion: The shorter, 5-day VIT regimen is an active and well-tolerated salvage regimen in relapse/refractory NB.
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http://dx.doi.org/10.3389/fonc.2022.804310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961432PMC
March 2022

Interactions between the breast tissue microbiota and host gene regulation in nonpuerperal mastitis.

Microbes Infect 2022 Apr-May;24(3):104904. Epub 2022 Mar 21.

Department of Breast Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, 330000, Jiangxi, China. Electronic address:

Background: Nonpuerperal mastitis (NPM) causes considerable psychological distress in females, since it is difficult to diagnose and treat. A spectrum of etiological factors can lead to NPM. However, the pathogenesis of NPM remains unclear. Here, we aimed to dissect the role of host gene-microbe interactions in NPM.

Methods: We compared the breast tissue microbiome between NPM patients and controls using 16S rRNA sequencing. We also compared the gut microbiome between NPM patients and healthy controls. Moreover, we investigated whether the breast tissue microbiome was associated with an altered gut microbiome in patients with NPM. We analyzed differentially expressed genes in inflammatory tissues of mammary gland from patients with NPM and normal mammary gland tissues from patients with benign and non-infectious breast disease by RNA-sequencing (RNA-seq). Lastly, we explored the association of specific bacterial taxa with differential expression of immune-related genes and differences in infiltrating immune cells.

Results: The breast tissue microbiome from NPM and controls showed significant differences in community composition. The breast tissue shared a relatively small proportion of bacterial communities with the gut in patients with NPM. Ruminococcus (family Ruminococcaceae) of breast tissue was positively correlated with the differentially expression of immune-related genes between NPM patients and controls, including antigen processing and presentation genes (ICAM1, LGMN, THBS1, TAP1, HSPA1B and HSPA1A), cytokine receptor gene IL15RA, and chemokine gene CCN1. Rhizobium of breast tissue was negatively correlated with the differentially expression of the antigen processing and presentation gene HSPA6 between NPM patients and controls. We also found that Ruminococcus (family Ruminococcaceae), Coprococcus, and Clostridium of breast tissue positively correlated with the difference of CD8 T cells between NPM patients and controls.

Conclusions: We preliminarily explored the potential role of host-microbe interactions in NPM. We demonstrate cross-talk between the breast tissue microbiome and the gut microbiome in patients with NPM. We suggest that NPM microbiome composition influences the immune microenvironment of the disease by affecting the transcriptome. This is an exploratory study and further investigation of host-microbe interactions and its potential mechanism in NPM development are warranted.
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http://dx.doi.org/10.1016/j.micinf.2021.104904DOI Listing
March 2022

Highly Sensitive Immunoresistive Sensor for Point-Of-Care Screening for COVID-19.

Biosensors (Basel) 2022 Feb 28;12(3). Epub 2022 Feb 28.

Department of Mechanical Engineering, University of Washington, Seattle, WA 98195, USA.

Current point-of-care (POC) screening of Coronavirus disease 2019 (COVID-19) requires further improvements to achieve highly sensitive, rapid, and inexpensive detection. Here we describe an immunoresistive sensor on a polyethylene terephthalate (PET) film for simple, inexpensive, and highly sensitive COVID-19 screening. The sensor is composed of single-walled carbon nanotubes (SWCNTs) functionalized with monoclonal antibodies that bind to the spike protein of SARS-CoV-2. Silver electrodes are silkscreen-printed on SWCNTs to reduce contact resistance. We determine the SARS-CoV-2 status via the resistance ratio of control- and SARS-CoV-2 sensor electrodes. A combined measurement of two adjacent sensors enhances the sensitivity and specificity of the detection protocol. The lower limit of detection (LLD) of the SWCNT assay is 350 genome equivalents/mL. The developed SWCNT sensor shows 100% sensitivity and 90% specificity in clinical sample testing. Further, our device adds benefits of a small form factor, simple operation, low power requirement, and low assay cost. This highly sensitive film sensor will facilitate rapid COVID-19 screening and expedite the development of POC screening platforms.
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http://dx.doi.org/10.3390/bios12030149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8946488PMC
February 2022

Fabrication of Bi-BiOCl plasmon photocatalysts for removal of aqueous emerging contaminants under visible light.

J Environ Sci (China) 2022 Aug 11;118:87-100. Epub 2022 Jan 11.

School of Construction and Environment Engineering, Shenzhen Polytechnic, Shenzhen 518055, China.

Photocatalytic oxidation of emerging contaminants (ECs) in water has recently gained extensive attentions. In this study, bismuth oxychloride-based plasmon photocatalysts (Bi-BiOCl) exhibiting high performance were successfully developed by reducing Bi on the surface of BiOCl. Consequently, the photocatalysts were used to remove ECs from water. The effects of developmental process and Bi metal plasmon resonance on the photoelectric performances of Bi-BiOCl were investigated through a series of characterizations. The UV-vis diffuse reflection and photoluminescence spectra revealed that the light absorption range of the photocatalyst gradually increased and the electron recombination rate gradually decreased with the introduction of Bi metals. The optimal removal rates of ciprofloxacin and tetrabromobisphenol A by Bi-BiOCl were 93.8% and 96.4%; the respective reaction rate constants were 5.48 and 4.93 times higher than that of BiOCl. The mechanism study indicated that main reactants in the photocatalytic system were •O radicals and photogenerated holes, and the existence of oxygen vacancies and Bi metals promoted electron transfer in photocatalyst. In conclusion, this research produces a novel, green, highly efficient, and stable visible light photocatalyst for the removal of ECs from water.
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http://dx.doi.org/10.1016/j.jes.2021.08.026DOI Listing
August 2022

A comprehensive analysis of the diagnostic and prognostic value associated with the family members in breast cancer.

Gland Surg 2022 Feb;11(2):389-411

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Background: The solute carrier (SLC) 7 family genes play central roles in cancer cell metabolism as glucose and glutamate transporters. However, their expression and prognostic value in breast cancer (BC) remains to be elucidated.

Methods: Clinical data from BC patients were downloaded from The Cancer Genome Atlas (TCGA) and the Kaplan-Meier (KM) plotter database. The mechanisms underlying the association between expression and overall survival (OS) were explored using Cox regression and log-rank tests. ESTIMATE gives a measure of the immune-cell infiltrates. Single-sample (ss) Gene Set Enrichment Analysis (GSEA) was conducted to quantify immune cell infiltration.

Results: High expression was associated with a poorer survival time in BC patients according to the TCGA and KM plotter data. was associated with good progression-free interval (PFI) and disease-specific survival (DSS) according to the TCGA data. Furthermore, was correlated with good prognosis of OS, distant metastasis-free survival (DMFS), relapse-free survival (RFS), and post-progression survival (PPS) according to the KM plotter data. expression was positively associated with OS, but was not strongly associated with PFI nor DSS in the TCGA data. However, was positively correlated with DMFS and RFS in the KM database analysis. had excellent diagnostic value in BC patients and was strongly correlated with tumor infiltration. T helper 2 (Th2) cells, CD56 bright natural killer (NK) cells, and NK cells were the most strongly correlated with the family genes, suggesting that these genes play a crucial role in BC partly by modulating immune infiltration.

Conclusions: and expression levels may be sensitive biomarkers for predicting BC outcomes. may be a potential diagnostic and prognostic biomarker in BC, but further studies are warranted to verify these results.
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http://dx.doi.org/10.21037/gs-21-909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899434PMC
February 2022

Reconfigurable, Stretchable Strain Sensor with the Localized Controlling of Substrate Modulus by Two-Phase Liquid Metal Cells.

Nanomaterials (Basel) 2022 Mar 7;12(5). Epub 2022 Mar 7.

School of Material and Energy, University of Electronic Science and Technology of China, Chengdu 610054, China.

Strain modulation based on the heterogeneous design of soft substrates is an effective method to improve the sensitivity of stretchable resistive strain sensors. In this study, a novel design for reconfigurable strain modulation in the soft substrate with two-phase liquid cells is proposed. The modulatory strain distribution induced by the reversible phase transition of the liquid metal provides reconfigurable strain sensing capabilities with multiple combinations of operating range and sensitivity. The effectiveness of our strategy is validated by theoretical simulations and experiments on a hybrid carbonous film-based resistive strain sensor. The strain sensor can be gradually switched between a highly sensitive one and a wide-range one by selectively controlling the phases of liquid metal in the cell array with a external heating source. The relative change of sensitivity and operating range reaches a maximum of 59% and 44%, respectively. This reversible heterogeneous design shows great potential to facilitate the fabrication of strain sensors and might play a promising role in the future applications of stretchable strain sensors.
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http://dx.doi.org/10.3390/nano12050882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912465PMC
March 2022

Stretchable 3D Wideband Dipole Antennas from Mechanical Assembly for On-Body Communication.

ACS Appl Mater Interfaces 2022 Mar 7;14(10):12855-12862. Epub 2022 Mar 7.

Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park 16802, Pennsylvania, United States.

The development of wearable/stretchable electronics could largely benefit from advanced stretchable antennas with excellent on-body performance upon mechanical deformations. Despite recent developments of stretchable antennas based on intrinsically stretchable conductors, they are often affected by lossy human tissues and exhibit resonant frequency shifts upon stretching, preventing their applications in on-body wireless communication and powering. This work reports a three-dimensional (3D) stretchable wideband dipole antenna from mechanical assembly to simultaneously reduce the frequency detuning and enhance on-body performance. The large bandwidth is achieved by coupling two resonances from two pairs of radiation arms, which is well-maintained even when the antenna is directly placed on human bodies or stretched over 25%. Such an excellent on-body performance allows the antenna to robustly transmit the wireless data and energy. The design of the 3D stretchable wideband dipole antenna with significantly enhanced on-body wireless communication performance was validated by an experimental demonstration that features a small difference in the wirelessly received power between the on-body and off-body use. The combination of the mechanically assembled 3D geometries and the coupled mechanical-electromagnetic properties can open up new opportunities in deformable 3D antennas and other microwave devices with excellent on-body performance and tunable properties.
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http://dx.doi.org/10.1021/acsami.1c24651DOI Listing
March 2022

Recent Progress in Daytime Radiative Cooling: Advanced Material Designs and Applications.

Small Methods 2022 Apr 25;6(4):e2101379. Epub 2022 Feb 25.

National Laboratory of Solid State Microstructures College of Engineering and Applied Sciences, Jiangsu Key Laboratory of Artificial Functional Materials, Frontiers Science Center For Critical Earth Material Cycling, Nanjing University, Nanjing, 210093, P. R. China.

Passive daytime radiative cooling (PDRC) is emerging as a promising cooling technology. Owing to the high, broadband solar reflectivity and high mid-infrared emissivity, daytime radiative cooling materials can achieve passive net cooling power under direct sunlight. The zero-energy-consumption characteristic enables PDRC to reduce negative environmental issues compared with conventional cooling systems. In this review, the development of advanced daytime radiative cooling designs is summarized, recent progress is highlighted, and potential correlated applications, such as building cooling, photovoltaic cooling, and electricity generation, are introduced. The remaining challenges and opportunities of PDRCs are also indicated. It is expected that this review provides an overall picture of recent PDRC progress and inspires future research regarding the fundamental understanding and practical applications of PDRC.
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http://dx.doi.org/10.1002/smtd.202101379DOI Listing
April 2022
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