Publications by authors named "Jia Ming Tian"

5 Publications

  • Page 1 of 1

Adjuvanted-influenza vaccination in patients infected with HIV: a systematic review and meta-analysis of immunogenicity and safety.

Hum Vaccin Immunother 2020 03 1;16(3):612-622. Epub 2019 Nov 1.

Medical school, Hunan University of Chinese Medicine, Changsha, Hunan, China.

Adjuvanted-influenza vaccination is an efficient method for enhancing the immunogenicity of influenza split-virus vaccines for preventing influenza. However, the medical community's understanding of its performance in patients infected with HIV remains limited. To identify the advantages, we conducted a systematic review and meta-analysis with randomized controlled trials (RCTs) and cohort and case-control studies that have the immunogenicity and safety of influenza vaccines in patients infected with HIV as outcomes. We searched six different databases, and 1698 patients infected with HIV in 11 studies were included. Statistical analysis was performed to calculate the pooled standardized mean differences (SMD) or relative risk (RR) and 95% confidence interval (CI). Regarding immunogenicity, the pooled SMD of GMT (Geometric mean titer) for A/H1N1 was 0.61 (95%CI (0.40,0.82)), the pooled RR of seroconversion was 1.34 (95%CI (0.91,1.98)) for the H1N1 vaccine, 1.27(95%CI (0.64,2.52)) for the H3N2 vaccine, 1.19(95%CI (0.97,1.46)) for the B-type influenza vaccine. The pooled RR of seroprotection was 1.61 (95%CI (1.00,2.58)) for the H1N1 vaccine, 1.06 (95%CI(0.83,1.35)) for the H3N2 vaccine, and 1.13(95%CI(0.91,1.41)) for the B-type vaccine. Adjuvanted-influenza vaccination showed good general tolerability in patients infected with HIV, with the only significant increase being the rate of local pain at the injection site (RR = 2.03, 95%CI (1.06,3.86)). In conclusion, all studies evaluating injected adjuvanted influenza vaccination among patients infected with HIV showed acceptable levels of safety and immunogenicity.
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March 2020

Simultaneous determination of six components in commercial Roukou Wuwei pills using ultra-high-performance liquid chromatography with diode-array detector.

Biomed Chromatogr 2019 Dec 2;33(12):e4677. Epub 2019 Sep 2.

Department of Pharmacy, Hebei North University, Zhangjiakou, P.R. China.

An efficient ultra-performance liquid chromatography with diode-array detector method was established for simultaneous determination of six active components in Roukou Wuwei pills, namely gallic acid, piperine, costundide, dehydrocostus lactone, isoalantolactone and alantolactone. Chromatographic separation of six components was successfully achieved on an Waters BEH C column (50 × 2.1 mm, 1.7 μm) with a mobile phase composed of acetonitrile and water using a gradient elution. Gallic acid and piperine were detected at 270 nm and 343 nm, respectively; while costundide, dehydrocostus lactone, isoalantolactone and alantolactone were simultaneously measured at 225 nm. All six calibration curves showed good linearity (R  ≥ 0.9994) between the peak area of each component and corresponding concentration. Relative standard deviations for inter- and intra-day precisions were <0.45 and 0.77%, respectively. The mean recovery rates ranged from 96.72 to 102.2% with relative standard deviations <2.07%. The developed method was validated in terms of linearity, precision and accuracy and then successfully applied for the quality control of commercial Roukou Wuwei samples.
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December 2019

Effects of calcium fertilizer application on absorption and distribution of nutrients in peanut under salt stress.

Ying Yong Sheng Tai Xue Bao 2018 Oct;29(10):3302-3310

Shandong Peanut Research Institute, Qingdao 266100, Shandong, China.

In order to solve the problems of nutrient absorption and accumulation and provide theoretical basis for rational amount of calcium fertilization of peanut in saline land, the effects of calcium fertilizer application on absorption and accumulation of nutrients including nitrogen, phosphorus, potassium, calcium and magnesium in peanut under salt stress were examined. Using 'Huayu 25' as experimental material, four Ca levels [T (0), T (75), T (150) and T (225) kg·hm CaO] were set under 0.3% salt stress in a pot experiment. The results showed that nutrient contents in peanut followed the order of nitrogen > potassium > calcium > phosphorus > magnesium. At the seedling stage, leaves were the absorption center of nitrogen and calcium, while stems were the center of phosphorus, potassium and magnesium, with nearly half of nutrient accumulation being distributed in the corresponding growth center. At mature stage, the absorption centers of nitrogen, phosphorus and potassium were transferred to pod. The accumulation of nitrogen and phosphorus in seed kernel reached to 72.3%-78.9%. The absorption centers of calcium and magnesium was still in the leaves and stems, with a distribution ratio of 49.8% and 32.6%, respectively. Salt stress significantly inhibited nutrient absorption and distribution in peanut, especially decreased the nitrogen accumulation in leaves and seed kernels. However, salt stress increased the magnesium accumulation in pod. Exogenous calcium application had significant positive effect on absorption and accumulation of nitrogen, phosphorus, calcium and magnesium in different organs of peanut under salt stress. It had significant adjustment on phosphorus accumulation in seed kernel, which was increased by more than 50%. Appropriate calcium content could significantly promote the peanut nutrient absorption and accumulation under salt stress and improve the distribution ratio of nitrogen, phosphorus, potassium in mature pods of peanut. According to the responses of nutrient absorption and distribution, the optimized application amount for calcium fertilizer under 0.3% salt stress was 150 kg·hm CaO.
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October 2018

Correlations of IFN-γ genetic polymorphisms with susceptibility to breast cancer: a meta-analysis.

Tumour Biol 2014 Jul 16;35(7):6867-77. Epub 2014 Apr 16.

College of Environment and Chemical Engineering, Yanshan University, Hebei Street No. 438, Qinhuangdao, 066004, People's Republic of China.

The meta-analysis was conducted to evaluate the correlations between common genetic polymorphisms in the IFN-γ gene and susceptibility to breast cancer. The following electronic databases were searched without language restrictions: MEDLINE (1966 ~ 2013), the Cochrane Library Database (issue 12, 2013), EMBASE (1980 ~ 2013), CINAHL (1982 ~ 2013), Web of Science (1945 ~ 2013), and the Chinese Biomedical Database (CBM) (1982 ~ 2013). Meta-analysis was performed with the use of the STATA statistical software. Odds ratios (OR) with their 95 % confidence intervals (95 % CIs) were calculated. Nine clinical case-control studies met all the inclusion criteria and were included in this meta-analysis. A total of 1,182 breast cancer patients and 1,525 healthy controls were involved in this meta-analysis. Three functional polymorphisms were assessed, including rs2069705 C>T, rs2430561 T>A, and CA repeats 2/X. Our meta-analysis results indicated that IFN-γ genetic polymorphisms might be significantly associated with an increased risk of breast cancer (allele model: OR = 1.37, 95 % CI = 1.03 ~ 1.83, P = 0.031; dominant model: OR = 1.55, 95 % CI = 1.01 ~ 2.37, P = 0.046; homozygous model: OR = 2.23, 95 % CI = 1.30 ~ 3.82, P = 0.004; respectively), especially the rs2430561 T>A polymorphism. Subgroup analysis based on ethnicity suggested that genetic polymorphisms in the IFN-γ gene were closely correlated with increased breast cancer risk among Asians (allele model: OR = 1.21, 95 % CI = 1.02 ~ 1.58, P = 0.017; dominant model: OR = 3.44, 95 % CI = 2.07 ~ 5.71, P < 0.001; recessive model: OR = 1.58, 95 % CI = 1.06 ~ 2.37, P = 0.025; homozygous model: OR = 1.83, 95 % CI = 1.19 ~ 2.80, P = 0.006; respectively), but not among Caucasians (all P > 0.05). Our meta-analysis supported the hypothesis that IFN-γ genetic polymorphisms may contribute to an increased risk of breast cancer, especially the rs2430561 T>A polymorphism among Asians.
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July 2014

[Study on the optimal extraction process of chaihushugan powder].

Zhong Yao Cai 2009 Nov;32(11):1746-8

Department of Pharmanacy, Hebei North College, Zhangjiakou 075000, China.

Objective: To study the optimal extraction process of chaihushugan powder by orthogonal design.

Methods: RP-HPLC method was developed for the determination of saikosaponin a, ferulic acid, hesperidin and paeoniflorin in chaihushugan powder. The contents of the components and the extraction yield were selected as assessment indices. Four factors were study by L9 (3(4)), including the alcohol concentration, amount of alcohol, duration of extraction and times of extraction.

Results: The optimal extracting condition was 80% alcohol consumed as 10 times of crude herb amount, and extracting two times for 90 min each time.

Conclusion: This study supplies theoretical base for the development of chaihushugan powder formulation.
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November 2009