Publications by authors named "Jia He"

697 Publications

A Case of Systemic Severe Bullous Pemphigoid Caused by Long-Term Sintilimab Treatment for Renal Cell Carcinoma.

Clin Cosmet Investig Dermatol 2022 10;15:1611-1614. Epub 2022 Aug 10.

Department of Dermatology, Affiliated Hospital of North Sichuan Medical College, Nanchong, People's Republic of China.

Immune-related adverse events have been reported in relation to programmed cell death protein-1 (PD-1). However, there are few reports on PD-1 inhibitor-induced bullous pemphigoid. We report the case of a patient who developed bullous pemphigoid following long-term administration of sintilimab for renal cell carcinoma. He developed scattered erythema, blisters, and generalized pruritus for 1 week before admission. Histopathology showed subepidermal blisters and direct immunofluorescence showed linear deposition of immunoglobulin G and complement 3 on the basement membrane; the level of BP180 was 146.93U/mL. A regimen containing methylprednisolone, minocycline, and niacinamide was administered and the patient was discharged following resolution of symptoms.
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http://dx.doi.org/10.2147/CCID.S374449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375974PMC
August 2022

Mannose ameliorates experimental colitis by protecting intestinal barrier integrity.

Nat Commun 2022 Aug 16;13(1):4804. Epub 2022 Aug 16.

The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong, 510900, China.

Metabolite alteration has been associated with the pathogenesis of inflammatory bowel disease (IBD), including colitis. Mannose, a natural bioactive monosaccharide that is involved in metabolism and synthesis of glycoproteins, exhibits anti-inflammatory and anti-oxidative activities. We show here that the circulating level of mannose is increased in patients with IBD and mice with experimental colitis. Mannose treatment attenuates intestinal barrier damage in two mouse colitis models, dextran sodium sulfate (DSS)-induced colitis and spontaneous colitis in IL-10-deficient mice. We demonstrate that mannose treatment enhanced lysosomal integrity and limited the release of cathepsin B, preventing mitochondrial dysfunction and myosin light chain kinase (MLCK)-induced tight junction disruption in the context of intestinal epithelial damage. Mannose exerts a synergistic therapeutic effect with mesalamine on mouse colitis. Cumulatively, the results indicate that mannose supplementation may be an optional approach to the treatment of colitis and other diseases associated with intestinal barrier dysfunction.
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http://dx.doi.org/10.1038/s41467-022-32505-8DOI Listing
August 2022

The adsorption-release behavior of sediment phosphorus in a typical "grass-algae" coexisting lake and its influence mechanism during the transition sensitive period.

Chemosphere 2022 Aug 8;307(Pt 3):135903. Epub 2022 Aug 8.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China; Institute of Water Environment Research, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China.

In the early stage of eutrophication, the coexistence of "grass and algae" in lakes is obvious. Understanding the P sorption-desorption behavior in natural sediments during the ecologically sensitive transition period has important scientific value for predicting the deterioration of lake ecosystems and formulating restoration measures, but the related mechanisms are still unclear. In this study, the analysis results of sedimentary dissolved organic matter (DOM) fractions, extractable Fe (hydr)oxide fractions and P adsorption experiments showed that sedimentary DOM fractions, especially the tyrosine-like protein fractions and microbial humic-like fractions, played a part in determining the EPC and K values of sediments in the plateau lake environment. The compound effect of amorphous Fe (hydr)oxides and sedimentary OM affected the increase of sedimentary P adsorption. Interestingly, these phenomena were strongly correlated with water depth. Furthermore, the distribution of water depth to aquatic plants indirectly regulated the values of sedimentary EPC and K. Meanwhile, the ability of submerged plants to control the sedimentary EPCandK values will be forced to shift shallowly, thereby forcing a significant reduction of areas with low EPC and high K values. This not only enhanced the risk of endogenous P release in lakes, but also accelerated the further deterioration of aquatic ecosystems. Therefore, studying the long-term scale changes of sedimentary EPC and K values can help to understand the duration of the lake ecological transition period and prevent the transitional deterioration of ecosystem.
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http://dx.doi.org/10.1016/j.chemosphere.2022.135903DOI Listing
August 2022

Chinese nurses' perceptions on toxic leadership behaviors of nurse managers: A qualitative study.

J Nurs Manag 2022 Aug 8. Epub 2022 Aug 8.

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

Aim: To explore the perceptions of Chinese registered nurses on toxic leadership behaviors of nurse managers and to determine its type, cause, and response measures.

Background: The nurse manager is the front-line leader of the nurses who provide services directly to patients. Previous evidence suggests that toxic leadership behaviors of nurse managers do exist, and it is necessary to understand the specifics of it.

Methods: We used phenomenological research methods to conduct semi-structured in-depth interviews among 12 nurses at a tertiary hospital in Wuhan over the period from January to March 2022. And the data were analyzed using Colaizzi 7-step analysis method.

Results: Four themes were discovered: (a) nurses' perceptions of toxic leadership behaviors; (b) toxic leadership behaviors of nurse managers; (c) reasons for toxic leadership behaviors of nurse managers; (d) measures for toxic leadership behaviors of nurse managers.

Conclusion: Chinese nurses are exposed to the toxic leadership of nurse managers for multiple reasons and respond differently.

Implications For Nursing Management: This study helps nursing managers identify which behaviors are harmful to the nurse which require special attention in developing strategies to buffer against nurse managers' toxic leadership.
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http://dx.doi.org/10.1111/jonm.13758DOI Listing
August 2022

Case Report: A Huge Calabash Heart: A Rare Case of Supracardiac Total Anomalous Pulmonary Venous Return.

Front Cardiovasc Med 2022 13;9:942808. Epub 2022 Jul 13.

The Second Xiangya Hospital of Central South University, Changsha, China.

A 46-year-old woman was admitted to the cardiovascular department because of a 3-month history of palpitations and exertional dyspnea. She had a history of a successful pregnancy at a very young age. The chest radiograph presented a "calabash" configuration. Echocardiogram discovered a large atrial septal defect with a suspected pulmonary vein abnormality. Cardiac CT revealed supracardiac total anomalous pulmonary venous return, whereby, all the pulmonary veins drain into a vertical vein and, finally, to the superior vena cava. Cardiac catheterization was consistent with anomalous pulmonary venous drainage without pulmonary hypertension. Finally, she underwent a successful surgical repair and appeared asymptomatic before her discharge.
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http://dx.doi.org/10.3389/fcvm.2022.942808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326046PMC
July 2022

The abundance of bifidobacterium in relation to visceral obesity and serum uric acid.

Sci Rep 2022 Jul 29;12(1):13073. Epub 2022 Jul 29.

Shulan (Hangzhou) Hospital Affiliated to Zhejiang, Shuren University Shulan International Medical College, Hangzhou, China.

Gut microbiome has been shown to play a role in the development of obesity in recent studies. Most of these studies on obesity were based on the BMI classification criteria, which doesn't distinguish Visceral adipose tissue (VAT) from subcutaneous adipose tissue (SAT). Some studies showed that VAT has a higher risk of inducing metabolic diseases than SAT. This study focused on the visceral obesity defined by increased visceral fat area. The present study was designed to investigate the association of visceral obesity with gut predominant microbiota and metabolic status. This study included 372 healthy individuals from medical examination center in Shulan Hangzhou Hospital. Quantitative polymerase chain reaction (q-PCR) technique was used to detect ten kinds of gut predominant bacteria in fresh feces. Visceral fat area (VFA) was measured by the bioimpedance analyzer (INBODY720, Korea). The abundance of Bifidobacterium significantly decreased in the visceral obesity group. Compared with the lean group, Visceral obesity group had significantly higher levels of LDL, TG, FBG, serum uric acid (SUA) and lower levels of HDL. SUA was an independent impact factor for Bifidobacterium. SUA was negatively correlated with Bifidobacterium and positively correlated with VFA. In the mediation analysis, SUA showed significant mediation effect. SUA may be a mediating factor between decreased Bifidobacterium and increased VAT.
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http://dx.doi.org/10.1038/s41598-022-17417-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338261PMC
July 2022

Development of the Volatile Fingerprint of Qu Aurantii Fructus by HS-GC-IMS.

Molecules 2022 Jul 15;27(14). Epub 2022 Jul 15.

Zhejiang Institute for Food and Drug Control, Hangzhou 310052, China.

Volatile components are important active ingredients of Rutaceae. In this study, HS-GC-IMS (headspace-gas chromatography-ion mobility spectrometry) was used to study the volatile compounds of Qu Aurantii Fructus, and a total of 174 peaks were detected, 102 volatile organic compounds (131 peaks) were identified. To compare the volatile compounds of Qu Aurantii Fructus with its similar medical herb, Aurantii Fructus, and their common adulterants, principal component analysis (PCA) and cluster analysis (CA) were performed based on the signal intensity of all the detected peaks. The results showed that Qu Aurantii Fructus and Aurantii Fructus ( L.) were clustered into one group, while their common adulterants could be well distinguished in a relatively independent space. In order to distinguish Qu Aurantii Fructus from Aurantii Fructus, the peaks other than the average intensity ±2 standard deviation (95% confidence interval) were taken as the characteristic components by using the Gallery Plot plug-in software. Additionally, the fingerprint method was established based on the characteristic compounds, which can be used to distinguish among Qu Aurantii Fructus, Aurantii Fructus and their common adulterants quickly and effectively. We found that the characteristic components with higher content of Qu Aurantii Fructus were nerol, decanal, coumarin and linalool. This study provides a novel method for rapid and effective identification of Qu Aurantii Fructus and a new dimension to recognize the relationship between Qu Aurantii Fructus and Aurantii Fructus.
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http://dx.doi.org/10.3390/molecules27144537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316875PMC
July 2022

Positive Correlation of the Gene Rearrangements and Evolutionary Rates in the Mitochondrial Genomes of Thrips (Insecta: Thysanoptera).

Insects 2022 Jun 27;13(7). Epub 2022 Jun 27.

MOA Key Lab of Pest Monitoring and Green Management, Department of Entomology, College of Plant Protection, China Agricultural University, Beijing 100193, China.

Extensive gene rearrangement is characteristic in the mitogenomes of thrips (Thysanoptera), but the historical process giving rise to the contemporary gene rearrangement pattern remains unclear. To better understand the evolutionary processes of gene rearrangement in the mitogenomes of thrips, we sequenced the mitogenome of the banded thrip species . First, we found a novel mitochondrial gene order in this species. This mitogenome is 16,947 bp in length and encodes the typical 37 coding genes (13 protein-coding genes, 22 tRNA genes, and two rRNA genes) of insects. The gene arrangement was dramatically different from the putative ancestral mitogenome, with 26 genes being translocated, eight of which were inverted. Moreover, we found a novel, conserved gene block, , which has not been previously reported in the mitogenomes of thrips. With this newly assembled mitogenome, we compared mitogenome sequences across Thysanoptera to assess the evolutionary processes giving rise to the current gene rearrangement pattern in thrips. Seven identical gene blocks were shared by two sequenced banded thrip mitogenomes, while the reversal of combined with TDRL events resulted in the different gene orders of these two species. In phylogenetic analysis, the monophyly of the suborders and families of Thysanoptera was well supported. Across the gene orders of 14 thrips, only two conserved gene blocks, and , could be found. Correlation analysis showed that the degree of gene rearrangement was positively correlated with the non-synonymous substitution rate in thrips. Our study suggests that the mitogenomes of thrips remain stable over long evolutionary timescales after massive rearrangement during early diversification.
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http://dx.doi.org/10.3390/insects13070585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321049PMC
June 2022

Positive Interactions between and on Goji Berry Plants.

Insects 2022 Jun 24;13(7). Epub 2022 Jun 24.

Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

The gall mite and the psyllid are serious Goji berry pests. The mite can be phoretic on the psyllid to overwinter, but it is unclear whether the vector can obtain benefits from the phoront during the growing season. After detachment, the mite shares the same habitat with its vector, so there are very likely to be interspecific interactions. To better understand whether the interactions are positive or negative, information on relationships between abundances of and on leaves is needed. Here, abundance was represented by the egg abundance because the inactive nymphs develop on the same sites after hatching. (1) We found a positive linear relationship between the gall diameter and the mite abundance in the gall (one more millimeter on gall diameter for every 30 mites increase), which provided a way to rapidly estimate mite abundances in the field by measuring gall diameters. (2) There was a positive relationship between the abundance of mites and psyllid eggs on leaves. (3) Both species had positive effects on each other's habitat selections. More importantly, the interactions of the two species prevented leaf abscission induced by (leaf lifespan increased by 62.9%), increasing the continuation of the psyllid population. Our study suggests positive interactions between two pests during the growing season. The positive relationship between and egg abundances highlights the increasing need for novel methods for Goji berry pest management. In practice, control can be efficient by eliminating its vector . Both pests can be controlled together, which reduces chemical usage.
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http://dx.doi.org/10.3390/insects13070577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316154PMC
June 2022

Anti-Aging Effect of the Stromal Vascular Fraction/Adipose-Derived Stem Cells in a Mouse Model of Skin Aging Induced by UVB Irradiation.

Front Surg 2022 8;9:950967. Epub 2022 Jul 8.

Department of Plastic Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China.

Adipose-derived stem cells(ADSCs) have been used for anti-photo-aging. But the purification of ADSCs requires amplification and culture, there is considerable risk of direct treatment for patients. Stromal vascular fraction(SVF) is a biologically and clinically interesting heterogeneous cell population contains ADSCs. There are few reports on anti-aging effects of SVF in photo-aging skin. The present study investigated the anti-aging effect of stromal vascular fraction (SVF) and adipose-derived stem cells (ADSCs) injection in photo-aging skin. The relationship between the dosage of injection and effect was also discussed. Thirty healthy, 6-week-old, nude rats were randomly divided into the control and experimental groups. The experimental group needing ultraviolet B (UVB) irradiation five days per week, and a duration of 8 weeks. According to different dose regimens of SVF and ADSCs, experiment rats were randomly grouped as the model control group, low-dose (LD) treatment group, middle-dose (MD) treatment group and high-dose (HD) treatment group. At 7 and 28 days post-treatment, specimens were harvested for histological and immunohistochemical analysis. We found that certain concentrations of cells (MD and HD groups) could improve the texture of photoaged skin. Changes in the epidermal cell layer were clearly observed after 7 days of treatment. The epidermal layer becomes thinner and more tender. After 28 days of treatment, the dermal tissue was thickened and the collagen content and proportion were improved. All these indicators showed no significant difference between the same dosages in the two treatment groups. Our results demonstrate that SVF may have anti-aging potential in photo-aging skin and the ADSCs play an important role in SVF. SVF maybe a potential agent for photo-anging skin and the most effective dose of SVF was 10 cells /100 µl/injection point. The proper injection interval may be 1.5 cm.
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http://dx.doi.org/10.3389/fsurg.2022.950967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304656PMC
July 2022

Clinical Profile and Prognosis of Hereditary Transthyretin Amyloid Cardiomyopathy: A Single-Center Study in South China.

Front Cardiovasc Med 2022 27;9:900313. Epub 2022 Jun 27.

Department of Cardiovascular Medicine, Second Xiangya Hospital, Central South University, Changsha, China.

Background: Hereditary transthyretin amyloid cardiomyopathy (ATTR-CM) is a genotypically heterogeneous disorder with a poor prognosis. There is limited literature describing the variants responsible for ATTRv in areas outside the United State, the United Kingdom and Europe. This study was performed to describe the clinical characteristics and genotypic profiles of this disease in South China.

Methods: This was a single-center retrospective study that evaluated 29 patients with a confirmed diagnosis of hereditary transthyretin amyloid cardiomyopathy enrolled from January 2016 to November 2021.

Results: 93.1% patients were male and the median age of symptom onset was 53 (46, 62.5) years old. The initial manifestations of ATTR-CM were cardiovascular symptoms (55.2%), neuropathy (41.4%) and vitreous opacity (3.4%). Phenotypes at diagnosis were mixed (82.8%), predominant cardiac (6.9%), neurological (6.9%) and ophthalmic (3.4%). Poor R-wave progression (41%), pseudo-infarct (31%) and low-voltage (31%) patterns were common findings on electrocardiogram. Unexplained increased wall thickness was observed in all 29 patients, with mean septal and posterior wall thicknesses of 14.25 ± 6.26 mm and 15.34 ± 2.84 mm, respectively. Diastolic dysfunction was also seen in all 29 patients, and 17 (58%) had a restrictive fill pattern at diagnosis. Nine different missense mutations of the TTR gene were found in 29 patients from 23 families, with c.349G>T (p.Ala117Ser) the most common mutation. The median survival time after diagnosis was 47.6 (95% CI 37.9-57.4) months, with 1, 3 and 5-year survival rates of 91.2%, 74% and 38% respectively. Patients with advanced heart failure (National Amyloidosis Staging stage II/III) had worse survival than stage I [Breslow (Generalized Wilcoxon), χ2 = 4.693, = 0.03)].

Conclusions: ATTR amyloidosis genotypes and phenotypes are highly heterogeneous. Advanced heart failure predicts a poor prognosis. Understanding the different clinical profiles of ATTR cardiac amyloidosis with different genotype is important to its early recognition.
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http://dx.doi.org/10.3389/fcvm.2022.900313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271707PMC
June 2022

Regulation of signaling pathways in hair follicle stem cells.

Burns Trauma 2022 4;10:tkac022. Epub 2022 Jul 4.

Department of Burn Surgery, The First People's Hospital of Foshan, Foshan 528000, China.

Hair follicle stem cells (HFSCs) reside in the bulge region of the outer root sheath of the hair follicle. They are considered slow-cycling cells that are endowed with multilineage differentiation potential and superior proliferative capacity. The normal morphology and periodic growth of HFSCs play a significant role in normal skin functions, wound repair and skin regeneration. The HFSCs involved in these pathophysiological processes are regulated by a series of cell signal transduction pathways, such as lymphoid enhancer factor/T-cell factor, Wnt/β-catenin, transforming growth factor-β/bone morphogenetic protein, Notch and Hedgehog. The mechanisms of the interactions among these signaling pathways and their regulatory effects on HFSCs have been previously studied, but many mechanisms are still unclear. This article reviews the regulation of hair follicles, HFSCs and related signaling pathways, with the aims of summarizing previous research results, revealing the regulatory mechanisms of HFSC proliferation and differentiation and providing important references and new ideas for treating clinical diseases.
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http://dx.doi.org/10.1093/burnst/tkac022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250793PMC
July 2022

Temporal trends, predictors of blood transfusion and in-hospital outcomes among patients with severe burn injury in the United States-A national database-based analysis.

Transfusion 2022 Aug 5;62(8):1537-1550. Epub 2022 Jul 5.

Department of Health Statistics, The Second Military Medical University, Shanghai, China.

Background: Severe burn can be accompanied by life-threatening bleeding on some occasions, thus, blood transfusion is often required in these patients during their hospitalization. Therefore, we aimed to examine temporal trends, predictors, and in-hospital outcomes of blood transfusion in these patients in the United States.

Methods: The National Inpatient Sample was used to identify severe burn patients between January 2010 and September 2017 in the United States. Trends in the utilization of blood transfusion were analyzed using the Cochran-Armitage trend test. Moreover, propensity score matching (PSM) was employed, and then in-hospital outcomes were compared between these two groups in the matched cohort. Multivariable logistic regressions were further used to validate the results of PSM.

Results: Among 27,260 severe burn patients identified during the study period, 2120 patients (7.18%) received blood transfusion. Blood transfusion rates decreased significantly from 9.52% in 2010 to 5.02% in 2017 (p for trend <.001). In the propensity-matched cohort (2120 pairs with and without transfusion), patients transfused were at increased risk of in-hospital mortality (13.3% vs 8.77%, p < .001), overall postoperative complications (88.3% vs 72.59%, p < .001), longer hospital stays (defined as > median hospital stays = 5 d) (73.8% vs 50.6%, p < .001) and increased overall cost (defined as > median overall costs = 30,746) (81.6% vs 57.3%, p < .001). This was also the case for the multivariable analysis.

Conclusions: Blood transfusion following severe burn injury may be associated with worse clinical outcomes. The utility for blood transfusion in burn patients warrants further prospective exploration.
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http://dx.doi.org/10.1111/trf.16999DOI Listing
August 2022

Huoxin pill prevents excessive inflammation and cardiac dysfunction following myocardial infarction by inhibiting adverse Wnt/β‑catenin signaling activation.

Phytomedicine 2022 Sep 26;104:154293. Epub 2022 Jun 26.

Fujian Key Laboratory of Integrative Medicine on Geriatric, Academy of Integrative, Medicine, Fujian University of Traditional Chinese Medicine, 1 Qiuyang Road, Minhou Shangjie, Fuzhou, Fujian 350122, China. Electronic address:

Background: Myocardial infarction (MI) is the most common cause of cardiac injury, resulting in widespread and irreversible damage to the heart. The incidence of MI gives rise to the excessive production of inflammatory cytokines that further promotes myocardial dysfunction. Wnt/β-catenin signaling pathway is adversely activated during MI and plays an important role in the modulation of the inflammatory response following tissue injury. Huoxin pill (HXP) is a Traditional Chinese Medicine formulation that has been long used in the treatment of cardiovascular diseases, however its mechanisms of cardioprotection remain unclear.

Methods: We performed murine models of MI in order to model myocardial ischemic damage and examine the effect and underlying mechanism of HXP in protecting against myocardial ischemic injury. We further constructed conditional cardiomyocyte-specific β-catenin knockout mice and induced surgical MI in order to better understand the role of Wnt/β-catenin signaling following myocardial infarction in the adult heart.

Results: HXP administration strongly protected against cardiac ischemic injury, improved cardiac function, and markedly decreased the expression of pro-inflammatory cytokines following MI. Nuclear activation of β‑catenin resulted in significantly increased nuclear translocation and activation of NF-κB. In contrast, cardiomyocyte-specific deletion of β-catenin decreased NF-κB activation and exhibited beneficial effects following ischemic injury. Hence, HXP protected against MI-induced ischemic injury and excessive inflammatory response via inhibiting Wnt/β‑catenin signaling.

Conclusions: Our study elucidated the role of HXP in protecting against ischemic myocardial injury via preventing MI-induced inflammatory response, which was mediated by its ability to inhibit adverse Wnt/β‑catenin signaling activation. Thus, our study provides the basis for the implementation of HXP as an effective therapeutic strategy in protecting against myocardial ischemic diseases.
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http://dx.doi.org/10.1016/j.phymed.2022.154293DOI Listing
September 2022

A Cardiovascular Disease Prediction Model Based on Routine Physical Examination Indicators Using Machine Learning Methods: A Cohort Study.

Front Cardiovasc Med 2022 17;9:854287. Epub 2022 Jun 17.

Department of Public Health, Shihezi University School of Medicine, Shihezi, China.

Background: Cardiovascular diseases (CVD) are currently the leading cause of premature death worldwide. Model-based early detection of high-risk populations for CVD is the key to CVD prevention. Thus, this research aimed to use machine learning (ML) algorithms to establish a CVD prediction model based on routine physical examination indicators suitable for the Xinjiang rural population.

Method: The research cohort data collection was divided into two stages. The first stage involved a baseline survey from 2010 to 2012, with follow-up ending in December 2017. The second-phase baseline survey was conducted from September to December 2016, and follow-up ended in August 2021. A total of 12,692 participants (10,407 Uyghur and 2,285 Kazak) were included in the study. Screening predictors and establishing variable subsets were based on least absolute shrinkage and selection operator (Lasso) regression, logistic regression forward partial likelihood estimation (FLR), random forest (RF) feature importance, and RF variable importance. The selected subset of variables was compared with L1 regularized logistic regression (L1-LR), RF, support vector machine (SVM), and AdaBoost algorithm to establish a CVD prediction model suitable for this population. The incidence of CVD in this population was then analyzed.

Result: After 4.94 years of follow-up, a total of 1,176 people were diagnosed with CVD (cumulative incidence: 9.27%). In the comparison of discrimination and calibration, the prediction performance of the subset of variables selected based on FLR was better than that of other models. Combining the results of discrimination, calibration, and clinical validity, the prediction model based on L1-LR had the best prediction performance. Age, systolic blood pressure, low-density lipoprotein-L/high-density lipoproteins-C, triglyceride blood glucose index, body mass index, and body adiposity index were all important predictors of the onset of CVD in the Xinjiang rural population.

Conclusion: In the Xinjiang rural population, the prediction model based on L1-LR had the best prediction performance.
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http://dx.doi.org/10.3389/fcvm.2022.854287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247206PMC
June 2022

Synergy effect of CuO on CuCoO for methane catalytic combustion.

RSC Adv 2022 Jun 14;12(27):17490-17497. Epub 2022 Jun 14.

Key Laboratory of Functional Molecule Design and Interface Process China.

Spinel oxides (ABO) have been widely studied as catalysts for methane combustion. Increasing attention was focused on the catalysis properties of the [BO] octahedron; however, the role of the [AO] tetrahedron in the catalytic activity was seldom discussed. Herein, a series of (CuO) -CuCoO ( = 0, 0.1, 0.2) composite oxides were synthesized by a solvothermal method. The structure, morphology, and physicochemical properties of the as-synthesized samples were characterized by the XRD, SEM, BET, and XPS techniques. The results of the catalytic activity tests showed that the coexistence of CuO with CuCoO can improve the catalytic activity. The XPS results demonstrated that there were remarkable Cu ions present in the composite oxides, which can cause increases in the number of oxygen vacancies on the surface of the catalysts. In addition, the redox of Cu and Cu may improve the oxygen exchange capacity for methane oxidation.
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http://dx.doi.org/10.1039/d2ra02237kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194921PMC
June 2022

Amino acids imprinted ZIF-8s for the highly efficient and selective adsorption of antioxidant peptides from silkworm pupa protein.

Food Res Int 2022 Jul 26;157:111406. Epub 2022 May 26.

MOE Key Laboratory of New Processing Technology for Nonferrous Metals and Materials, Guangxi Key Laboratory of Processing for Non-ferrous Metals and Featured Materials, School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China; Guangxi Bossco Environmental Protection Technology Co., Ltd, Nanning 530007, China. Electronic address:

Antioxidant peptides from edible protein sources have attracted great attention due to their high activity, easy adsorption and low toxicity. The purpose of this study was to develop a new MOF material with specific recognition and capture ability to achieve the aim of highly efficient and selective antioxidant peptides from silkworm pupa protein hydrolysate-N (SPPH-N). Firstly, Histidine (His) widely presented in antioxidant peptides was used to in-suit construct the modified ZIF-8 material (ZIF-His) with imprinted defective mesopores, based on "molecular imprinting strategy". Then, it was applied to extract antioxidant peptides from SPPH-N. ZIF-His exhibited high adsorption uptake for antioxidant peptides and especially presented specific adsorption property for peptides contained His, tryptophan, phenylalanine and tyrosine. Three peptides with the highest antioxidant activity (FKVPNMY, AVNMVPFPR and VNMVPFPR) from ZIF-His eluent were identified by Nano-LC-MS/MS. These peptides were synthesized and presented the excellent free radicals scavenging activity and the Ferric reducing power.
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http://dx.doi.org/10.1016/j.foodres.2022.111406DOI Listing
July 2022

Metabolic Dysfunction-Associated Fatty Liver Disease Is Associated with the Risk of Incident Cardiovascular Disease: A Prospective Cohort Study in Xinjiang.

Nutrients 2022 Jun 7;14(12). Epub 2022 Jun 7.

Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, China.

In 2020, a group of international experts proposed a new term 'metabolic dysfunction-associated fatty liver disease' (MAFLD) to replace 'non-alcoholic fatty liver disease'. This study aimed to describe the epidemic characteristics of MAFLD, incidence of cardiovascular disease (CVD), and relationship between MAFLD and incident CVD. In 2016, 12,794 Uyghur adults from Kashgar, Xinjiang, were grouped according to the presence or absence of MAFLD. The primary outcome was the occurrence of CVD events. Fatty liver was diagnosed using ultrasound. The prevalence of MAFLD was 16.55%. After excluding patients with previous CVD, 11,444 participants were followed up for a median period of 4.7 years. During the follow-up period, the overall CVD incidence was 10.40% (1190/11,444). The incidence of CVD in the patients with MAFLD was significantly higher than that in the non-MAFLD patients (18.38% vs. 9.02%, < 0.001; multivariable-adjusted hazard ratio = 1.37, 95% CI = 1.20-1.56). The prevalence of MAFLD was relatively low, whereas the incidence of CVD was relatively high among the Uyghur adults in rural Xinjiang. Individuals with MAFLD have a higher risk of developing CVD independent of traditional cardiovascular risk factors, obesity, type 2 diabetes mellitus (T2DM), and dyslipidaemia.
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http://dx.doi.org/10.3390/nu14122361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231197PMC
June 2022

Phase I study of adjuvant immunotherapy with autologous tumor-infiltrating lymphocytes in locally advanced cervical cancer.

J Clin Invest 2022 Aug;132(15)

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine.

BACKGROUNDAdoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) has achieved remarkable clinical efficacy in metastatic cancers such as melanoma and cervical cancer (CC). Here, we explored the safety, feasibility, and preliminary tumor response and performed translational investigations of adjuvant immunotherapy using infusion of autogenous TILs (auto-TILs) following concurrent chemoradiotherapy (CCRT) in patients with CC who had locally advanced disease.METHODSTwenty-seven patients with CC with stage III-IV disease were recruited in this single-center, phase I study. TILs were isolated from lesions in the uterine cervix and generated under good manufacturing practice (GMP) conditions and then infused after CCRT plus i.m. IL-2 injections.RESULTSTILs from 20 of the 27 patients were successfully expanded, with a feasibility of 74.1%. Twelve patients received TILs following CCRT. Adverse events (AEs) were primarily attributable to CCRT. Only 1 (8.3%) patient experienced severe toxicity with a grade 3 hypersensitivity reaction after TIL infusion. No autoimmune AEs, such as pneumonitis, hepatitis, or myocarditis, occurred, and there were no treatment-related mortalities. Nine of 12 patients (75.0%) attained a complete response, with a disease control duration of 9-22 months. Translational investigation showed that the transcriptomic characteristics of the infused TIL products and some immune biomarkers in the tumor microenvironment and serum of patients with CC at baseline were correlated with the clinical response.CONCLUSIONTIL-based ACT following CCRT was safe in an academic center setting, with potentially effective responses in patients with locally advanced CC. "Hot" inflammatory immune environments were beneficial to the clinical efficacy of TIL-based ACT as adjuvant therapy.TRIAL REGISTRATIONClinicalTrials.gov NCT04443296.FUNDINGNational Key R&D Program; Sci-Tech Key Program of the Guangzhou City Science Foundation; the Guangdong Province Sci-Tech International Key Program; the National Natural Science Foundation of China.
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http://dx.doi.org/10.1172/JCI157726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337833PMC
August 2022

A Site Distance Effect Induced by Reactant Molecule Matchup in Single-Atom Catalysts for Fenton-Like Reactions.

Angew Chem Int Ed Engl 2022 Aug 8;61(33):e202207268. Epub 2022 Jul 8.

Department of Chemistry, Tsinghua University, Beijing, 100029, China.

Understanding the site interaction nature of single-atom catalysts (SACs), especially densely populated SACs, is vital for their application to various catalytic reactions. Herein, we report a site distance effect, which emphasizes how well the distance of the adjacent copper atoms (denoted as d ) matches with the reactant peroxydisulfate (PDS) molecular size to determine the Fenton-like reaction reactivity on the carbon-supported SACs. The optimized d in the range of 5-6 Å, which matches the molecular size of PDS, endows the catalyst with a nearly two times higher turnover frequency than that of d beyond this range, accordingly achieving record-breaking kinetics for the oxidation of emerging organic contaminants. Further studies suggest that this site distance effect originates from the alteration of PDS adsorption to a dual-site structure on Cu -Cu sites when d falls within 5-6 Å, significantly enhancing the interfacial charge transfer and consequently resulting in the most efficient catalyst for PDS activation so far.
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http://dx.doi.org/10.1002/anie.202207268DOI Listing
August 2022

Plasma miR-193b-3p Is Elevated in Type 2 Diabetes and Could Impair Glucose Metabolism.

Front Endocrinol (Lausanne) 2022 27;13:814347. Epub 2022 May 27.

Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Huazhong University of Science and Technology, Wuhan, China.

Objective: To explore differentially expressed miRNAs in type 2 diabetes and their potential cellular functions.

Methods: We screened plasma miRNAs by miRNA array analysis and validated them by TaqMan real-time PCR in 113 newly diagnosed, untreated type 2 diabetes cases and 113 healthy controls. Low-abundance plasma proteins encoded by miR-193b-3p target genes were explored in this study population. We further investigated the potential cellular functions of the differentially expressed miRNAs in HepG2 cells.

Results: miR-193b-3p was differentially expressed in type 2 diabetes cases compared to healthy controls (fold change = 2.01, = 0.006). Plasma levels of triosephosphate isomerase (TPI1, a protein involved in the glycolytic pathway) decreased in type 2 diabetes cases (fold change = 1.37, = 0.002). The effect of miR-193b-3p on TPI1 was verified by transfection of miR-193b-3p into HepG2 cells. miR-193b-3p inhibited the expression of YWHAZ/14-3-3ζ in the PI3K-AKT pathway, subsequently altering the expression of FOXO1 and PCK1. After transfection, cells were incubated in glucose-free medium for another 4 h. Glucose levels in medium from cells with elevated miR-193b-3p levels were significantly higher than those in medium from negative control cells ( = 0.016). In addition, elevated miR-193b-3p reduced glucose uptake by inhibiting insulin receptor (IR) and GLUT2 expression.

Conclusion: Plasma miR-193b-3p levels increased in type 2 diabetes cases, and TPI1 levels decreased in both plasma and HepG2 cells with increased miR-193b-3p levels, while extracellular lactate levels did not significantly changed. Moreover, miR-193b-3p may affect glucose metabolism by directly targeting YWHAZ/14-3-3ζ and upregulating the transcription factor FOXO1 downstream of the PI3K-AKT pathway.
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http://dx.doi.org/10.3389/fendo.2022.814347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197112PMC
May 2022

Haizao Yuhu decoctions including three species of glycyrrhiza protected against propylthiouracil-induced goiter with hypothyroidism in rats via the AMPK/mTOR pathway.

J Ethnopharmacol 2022 Oct 6;296:115443. Epub 2022 Jun 6.

Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address:

Ethnopharmacological Relevance: Glycyrrhiza and sargassum are among the 18 incompatible medicaments according to traditional Chinese medicine (TCM) theory. Although it contains glycyrrhiza and sargassum, Haizao Yuhu decoction (HYD) is a classic prescription widely used as TCM to treat goiter. According to the Chinese Pharmacopoeia, glycyrrhiza is divided into three varieties: Glycyrrhiza uralensis Fish., Glycyrrhiza glabra L., and Glycyrrhiza inflata Bat. Whether the three varieties of glycyrrhiza have different efficacy or toxicity when applied in the HYD is unknown.

Aim Of The Study: To explore whether the HYDs comprising three varieties of glycyrrhiza have different efficacy or toxicity when used to treat goiter in rats and the underlying mechanisms of these HYDs.

Materials And Methods: For two weeks, the goiter model was replicated by intragastric propylthiouracil (PTU) administration. Samples were divided into the control group, model group, euthyrox group, HYD with glycyrrhiza uralensis (HYD-U) group, HYD with glycyrrhiza glabra (HYD-G) group, and HYD with glycyrrhiza inflata (HYD-I) group. After four weeks of treatment, body weight, rectal temperature, thyroid/liver/kidney coefficient, thyroid/liver/kidney function, thyroid/liver/kidney histomorphology, and thyroid ultrastructure were evaluated. Then, real-time quantitative reverse-transcription polymerase chain reaction (RTqPCR), Western blot, and immunofluorescence analyses were performed to detect genes and proteins affecting autophagy and apoptosis in thyroid cells in the AMP-activated Protein Kinases (AMPK)/Mammalian target of rapamycin (mTOR) pathway.

Results: All three HYDs increased thyroid hormones (THs) levels, relieved thyroid pathological tissue and ultrastructure, and activated vital proteins and genes in the AMPK/mTOR pathway. Comparisons among the efficacy of the three HYDs indicated that HYD-U restored the THs most effectively; however, no difference in the anti-goiter effect was observed. Moreover, the three HYDs resulted in no toxicity and promoted the recovery of impaired liver and kidney function caused by PTU. Comparisons among the recovery effects of the three HYDs on the liver and kidney were the same.

Conclusion: Our experiments demonstrated that the three HYDs had outstanding anti-goiter effects and protected liver and kidney function. Their anti-goiter effects were attributed to AMPK/mTOR pathway-induced autophagy and apoptosis. HYD-U resulted in the best THs recovery. It was further indicated that in our present study, glycyrrhiza and sargassum were compatible in the three HYDs, thereby suggesting their safety of compounding in HYD and providing a basis for the research of the 18 incompatible medicaments.
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http://dx.doi.org/10.1016/j.jep.2022.115443DOI Listing
October 2022

Effect of enamel-surface modifications on shear bond strength using different adhesive materials.

BMC Oral Health 2022 06 7;22(1):224. Epub 2022 Jun 7.

Department of Orthodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Diseases, China Medical University, Shenyang, 110002, China.

Background: This study aimed to investigate the effect of enamel-surface modifications on the shear bond strength between ceramic brackets bonded using different adhesive materials and the enamel surface and to identify the most suitable clinical adhesive and bonding method. Whether the non-acid-etching treatment met the clinical bond strength was also determined.

Methods: A total of 108 extracted premolars were divided into nine groups (n = 12) based on the different enamel-surface modification techniques (acid etching, deproteinization, and wetting). Group 1 was bonded with Transbond™ XT adhesive, whereas groups 2-9 were bonded with resin-modified glass ionomer cement (RMGIC). The treatment methods for each group were as follows: groups 1 and 2, acid etching; group 3, acid etching and wetting; group 4, acid etching and deproteinization; group 5, acid etching, deproteinization, and wetting; group 6, deproteinization; group 7, deproteinization and wetting; group 8, without treatment; and group 9, wetting. The samples' shear bond strength was measured using an universal testing machine. Adhesive remnant index (ARI) was examined using a stereomicroscope. The enamel-surface morphology was observed with a scanning electron microscope. One-way ANOVA with Tukey's post-hoc test and chi-square test were used for statistical analysis, and p < 0.05 and α = 0.05 were considered statistically significant.

Results: The ARIs of groups 1-5 and 6-9 were statistically significant (p = 0.000). The enamel surface of groups 1-5 was demineralized, and only a tiny amount of protein remained in groups 7 and 8, whereas a thick layer of protein remained in groups 8 and 9.

Conclusions: RMGIC adhesive did not damage the enamel surface and achieved the required clinical bond strength. The enamel surface was better treated with 5.25% sodium hypochlorite preferably under non-acid-etching conditions.
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http://dx.doi.org/10.1186/s12903-022-02254-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9175421PMC
June 2022

Scalable and Sensitive Humidity-Responsive Polymer Photonic Crystal Films for Anticounterfeiting Application.

ACS Appl Mater Interfaces 2022 Jun 3. Epub 2022 Jun 3.

State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai 200433, P. R. China.

In this study, we fabricate a new kind of ultrasensitive humidity-responsive photonic crystal (HPC) films based on emulsion polymerization and the open mill and bending-induced ordering technique (OM-BIOT) method, which is simple and scalable. The HPC film senses relative humidity (RH) from 9 to 98% for the polymer matrix swells up in high RH and shrinks in low RH, leading to a large reflectance shift (81 nm) and distinct color change. Based on the double-peak reflective spectra of the HPC film, we confirm the gradient swelling hypothesis and find that the thickness is another important factor for controlling the sensitivity and response rate of the HPC film. Except for static humidity, the HPC film can also respond to the dynamic humid flow of blowing and polar solvents, which broadens its application potential. This kind of HPC film shows a vivid structural color, and the humidity-responsive behavior is quick, distinct, energy-free, and reversible, having a great prospect for anticounterfeiting application.
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http://dx.doi.org/10.1021/acsami.2c06273DOI Listing
June 2022

Effect of dissolved organic matter and heavy metals ions on sorption of phenanthrene at sedimentary particle scale.

J Hazard Mater 2022 08 20;436:129175. Epub 2022 May 20.

Kunming Institute of Eco-Environmental Sciences, Kunming, Yunnan 650032, People's Republic of China.

Human activities significantly increase the input of offshore heavy metals and organic pollutants. Although particle-scale and heterogeneous organic matters are fundamentally important to the fate of hydrophobic organic compounds (HOCs), deep understanding of the adsorption mechanism of HOCs on soil/sediment particles under the influence of heavy metal and organic pollution input is needed. This study investigates the effects of exotic DOM and heavy metals ions on the phenanthrene adsorption on sediment fractions. The adsorption experiments demonstrated that exotic DOM increased phenanthrene adsorption amount of sediment, with the greatest enhancement on clay particles (<2 µm). Nevertheless, the mechanism was differentiated accordingly to particle dimensions in terms of increased binding coefficients and mobility of phenanthrene. Furthermore, the introduction of heavy metals considerably enhanced the nonlinear sorption of phenanthrene. The Freundlich exponent N reduced by 0.01-0.24 when adding Cu, Zn and Pb, especially for coarse particles (31-63 µm) fraction. In comparison, the enhancement of nonlinearity adsorption by Cu and Zn is significantly lower than Pb ions. To our knowledge, the particle-scale study broadens the horizon of environmental fate and ecological risk of HOCs in intertidal regions, which is significantly affected by tidal action.
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http://dx.doi.org/10.1016/j.jhazmat.2022.129175DOI Listing
August 2022

Adverse Reactions to Facemasks in Health-Care Workers: A Cross-Sectional Survey.

Clin Cosmet Investig Dermatol 2022 25;15:947-954. Epub 2022 May 25.

The Health Administration Center, Zhejiang Rongjun Hospital, Jiaxing, Zhejiang Province, 314000, People's Republic of China.

Background: Coronavirus disease 2019 (COVID-19) has developed into a worldwide pandemic, which presents several challenges for frontline health-care workers (HCWs). HCWs are highly prone to various skin diseases due to prolonged use of personal protective equipment (PPE). The most frequently used type of PPE is facemasks. To effectively control adverse skin reactions, there is an urgent need for a range of preventive practices.

Methods: This cross-sectional study was conducted at 12 hospitals in Zhejiang province, China. HCWs were invited to participate in the web survey. Data were extracted by two independent reviewers using a predesigned data collection form and analyzed with SPSS 20.0.

Results: A total of 1147 questionnaires were collected, and of these, 1090 (95.03%) were valid and returned. The incidence of chest tightness and shortness of breath and face eczema was significantly higher in HCWs wearing N95 facemasks (41.91%; 31.62%) than in the HCWs wearing medical facemasks (38.05%, = 0.010; 21.91%, = 0.012). The incidence of ear pain and indentation was significantly higher in HCWs wearing hang-facemasks (83.81%) than in HCWs wearing strains-facemasks (61.19%, < 0.001). The incidence of ear pain and indentation was significantly higher in HCWs wearing undiscriminating size code facemasks (79.88%) than in the HCWs wearing discriminating size code facemasks (67.86%, = 0.031). There was a significant reduction (  <  0.001) in the incidence of HCWs without adverse reactions (ADRs) with increasing time wearing facemasks.

Conclusion: Incidence of ADRs does not significantly increase with the durations of mask wear where wearing mask time exceeded 4 hours per day. The medical staff generally wore masks for more than 4 hours per day; therefore, we recommend taking 15 min of rest after 2 hours of mask-wearing. Results in this study support the conclusion that the type of strain-facemasks and discriminating size code facemasks has a lower incidence of ADRs than other type of medical facemasks.
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http://dx.doi.org/10.2147/CCID.S365390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148581PMC
May 2022

The Mechanism of Long Non-coding RNA in Cancer Radioresistance/Radiosensitivity: A Systematic Review.

Front Pharmacol 2022 5;13:879704. Epub 2022 May 5.

Faculty Affairs and Human Resources Management Department, Southwest Medical University, Luzhou, China.

Radioresistance remains a significant challenge in tumor therapy. This systematic review aims to demonstrate the role of long non-coding RNA (lncRNA) in cancer radioresistance/radiosensitivity. The electronic databases Pubmed, Embase, and Google Scholar were searched from January 2000 to December 2021 to identify studies addressing the mechanisms of lncRNAs in tumor radioresistance/sensitivity, each of which required both and experiments. Among the 87 studies identified, lncRNAs were implicated in tumor radioresistance/sensitivity mainly in three paradigms. 1) lncRNAs act on microRNA (miRNA) by means of a sponge, and their downstream signals include some specific molecular biological processes (DNA repair and chromosome stabilization, mRNA or protein stabilization, cell cycle and proliferation, apoptosis-related pathways, autophagy-related pathways, epithelial-mesenchymal transition (EMT), cellular energy metabolism) and some signaling mediators (transcription factors, kinases, some important signal transduction pathways) that regulate various biological processes. 2) lncRNAs directly interact with proteins, affecting the cell cycle and autophagy to contribute to tumor radioresistance. 3) lncRNAs act like transcription factors to initiate downstream signaling pathways and participate in tumor radioresistance. lncRNAs are important regulators involved in tumor radioresistance\sensitivity. Different lncRNAs may participate in the radioresistance with the same regulatory paradigm, and the same lncRNAs may also participate in the radioresistance in different ways. Future research should focus more on comprehensively characterizing the mechanisms of lncRNAs in tumor radioresistance to help us identify corresponding novel biomarkers and develop new lncRNA-based methods to improve radioresistance.
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http://dx.doi.org/10.3389/fphar.2022.879704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117703PMC
May 2022

Water depth determines spatial and temporal phosphorus retention by controlling ecosystem transition and P-binding metal elements.

Water Res 2022 Jul 4;219:118550. Epub 2022 May 4.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, 8 Dayangfang, Beijing 100012, China; National Engineering Laboratory for Lake Pollution Control and Ecological Restoration, Chinese Research Academy of Environmental Sciences, Beijing 100012, China; Institute of Water Environment Research, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. Electronic address:

Shallow lakes are more susceptible to eutrophication than deep lakes. The geochemical and biogeochemical mechanisms controlling the vulnerability to eutrophication for deep lakes and shallow lakes remain unknown. Therefore, we investigated the combined Phosphorus (P) retention mechanism with P fractions, water depth, distribution of P-binding metal elements, and macrophytes coverage in a degrading ecosystem of Erhai Lake. We concluded that different mechanisms control the P retention in deep-water areas and shallow-water areas. In shallow areas covered by macrophytes, the biogeochemical process manipulates the P retention by changing the total organic carbon (TOC), calcium (Ca) distributions and turbulence. In deep areas without macrophyte coverage, the aluminum (Al) and iron (Fe) distributions control the P retention by a physicochemical process. Manganese (Mn) was found to be a potential proxy in tracking the kinetic release and readsorb of redox-sensitive P (BD-P) in deep areas. The historical record and core sample indicate that the hydrological engineering induced water depth variation is a vital factor changing the ecosystem of Erhai Lake by forming a large area of intermediate area where macrophytes could only survive at low water level. The uplift of water level in the 1990s gradually changed the ecosystem of Erhai Lake from macrophyte-dominated to algal-macrophyte concomitant that reduced the accumulation of stable P fractions and their binding metals. Macrophytes were capable to preserve P in biomass in the macrophyte-dominated ecosystem, which released 150% and 72% of more labile organic P (NaOH25-nrP) and BD-P in the sediment after the deterioration than before, respectively. Therefore, water depth is a prerequisite to restoring the P preservation capacity of sediment and the macrophyte ecosystem. Further hydraulic engineering projects should consider the effect of water-level-variation-induced ecosystem transition.
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http://dx.doi.org/10.1016/j.watres.2022.118550DOI Listing
July 2022

The role of perceived discrimination in linking religious practices and well-being: A study among Muslim Afghan refugees in the Netherlands.

Int J Psychol 2022 Aug 10;57(4):445-455. Epub 2022 May 10.

Ministry of Justice and Security, The Hague, The Netherlands.

Minorities facing adverse intergroup contact can experience both increased identification with their ethnic group and decreased identification with a host majority group. First, we argue it is important to understand what is associated with adversity, particularly in previously overlooked samples. Muslim refugee samples are often treated differently and experience more adversity than other immigrants. Second, we combine insights on the role of religiosity in acculturation with the observation that religiosity may not have positive effects in societies that do not value (a specific) religion (religiosity-as-social-value hypothesis) as well as insights from rejection (dis)identification models, to understand which domains of being a Muslim are associated with discrimination, (dis-)identification and well-being. We hypothesized that Muslim religious practices, but not beliefs, coping or values, are associated with increased perceived discrimination, and suggest that this is because practices are highly visible. Data from Muslim Afghan refugees in the Netherlands (N = 183) revealed that indeed only religious practices were related positively to perceived discrimination. Perceived discrimination in turn mediated the relationship between religious practices and dis-identification with the majority group, as well as the relationship between religious practices and well-being. We suggest that the visibility of one's religious behaviour is relevant for acculturation outcomes.
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http://dx.doi.org/10.1002/ijop.12854DOI Listing
August 2022

Dynamic Bayesian network for predicting physiological changes, organ dysfunctions and mortality risk in critical trauma patients.

BMC Med Inform Decis Mak 2022 05 3;22(1):119. Epub 2022 May 3.

Department of Health Statistics, Naval Medical University, No. 800 Xiangyin Road, Shanghai, 200433, China.

Background: Critical trauma patients are particularly prone to increased mortality risk; hence, an accurate prediction of their conditions enables early identification of patients' mortality status. Thus, we aimed to develop and validate a real-time prediction model for physiological changes, organ dysfunctions and mortality risk in critical trauma patients.

Methods: We used Dynamic Bayesian Networks (DBNs) to model complicated relationships of physiological variables across time slices, accessing data of trauma patients from the Medical Information Mart for Intensive Care database (MIMIC-III) (n = 2915) and validated with patients' data from ICU admissions at the Changhai Hospital (ICU-CH) (n = 1909). The DBN model's evaluation included the predictive ability of physiological changes, organ dysfunctions and mortality risk.

Results: Our DBN model included two static variables (age and sex) and 18 dynamic physiological variables. The differences in ratios between the real values and the 24- and 48-h predicted values of most physiological variables were within 5% in the two datasets. The accuracy of our DBN model for predicting renal, hepatic, cardiovascular and hematologic dysfunctions was more than 0.8.The calculated area under the curve (AUC) from receiver operating characteristic curves and 95% confidence interval for predicting the 24- and 48-h mortality risk were 0.977 (0.967-0.988) and 0.958 (0.945-0.971) in the MIMIC-III and 0.967 (0.947-0.987) and 0.946 (0.925-0.967) in ICU-CH.

Conclusions: A DBN is a promising method for predicting medical temporal data such as trauma patients' mortality risk, demonstrated by high AUC scores and validation by a real-life ICU scenario; thus, our DBN prediction model can be used as a real-time tool to predict physiological changes, organ dysfunctions and mortality risk during ICU admissions.
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http://dx.doi.org/10.1186/s12911-022-01803-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063308PMC
May 2022
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