Publications by authors named "Jia Chen"

1,284 Publications

  • Page 1 of 1

Predictive value of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score and lymphocyte-to-monocyte ratio (LMR) in patients with non-small cell lung cancer after radical lung cancer surgery.

Ann Transl Med 2021 Jun;9(12):976

Department of Oncology, Nantong University, Nantong, China.

Background: Examining the analytical worth of the preoperative hemoglobin, albumin, lymphocyte, platelet (HALP) score and lymphocyte-to-monocyte ratio (LMR) within diseased persons having non-small cell lung cancer (NSCLC) after radical lung cancer surgery.

Methods: Clinical data concerning 238 diseased persons with NSCLC who underwent radical lung cancer resection within Nantong Cancer Hospital between January 2009 and October 2015 had been looking back studied. ROC curve had been employed in regulating optimal critical worth of HALP and LMR that had been 48.00 and 6.30 singly. A 5-year amplification observed survival concerning diseased persons, and clinicopathological stuff assessed using statistics procedure. Kaplan Meier method, log rank test had been exploited from the point of view to analyze for surviving, and Cox regression analysis had been exploited for univariate and multivariate analysis. Eventually, a nomogram had been produced to examine the confirmation internally.

Results: Kaplan Meier survival assessment revealed top HALP class's overall survival (OS) was significantly higher than below HALP class's (P<0.001), and high LMR group's OS was also greater than below LMR class's (P=0.001). Patients possessing average continuance period of 4 years. Further stratified study revealed high HALP class possessed notable OS as compared below HALP class (P=0.0002), and top LMR class possessed considerable OS as compared to below LMR class (P=0.003) in lung adenocarcinoma. In non-adenocarcinoma, there was no substantial difference in OS between two classes (P>0.05). Preoperative HALP and LMR remained independent risk constituents for tumor progression (P=0.005, P=0.028), lymph node metastasis and level of differentiation also had a certain effect on tumor progression (P<0.05), according to Cox multivariate analysis. Rise in HALP and LMR will help diseased persons having NSCLC live longer. The nomogram's c-index in inside validation was 0.672 (95% confidence interval: 0.626-0.718).

Conclusions: Preoperative HALP versus LMR are independent predictive aspect within NSCLC diseased persons linked to clinicopathological features, and has a particular value in determining bodement.
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http://dx.doi.org/10.21037/atm-21-2120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267290PMC
June 2021

Efficiency and Toxicity of Ruxolitinib as a Salvage Treatment for Steroid-Refractory Chronic Graft-Versus-Host Disease.

Front Immunol 2021 30;12:673636. Epub 2021 Jun 30.

National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, China.

Graft-versus-host disease (GVHD), especially steroid-refractory GVHD, remains a life-threatening complication after hematopoietic stem cell transplantation (HSCT). The effect of the JAK1/2 kinase inhibitor ruxolitinib on treating steroid-refractory acute GVHD has been verified by the REACH1/2 study; however, its safety and efficacy in patients with steroid-refractory chronic GVHD (SR-cGVHD) remain unclear. In this retrospective study, 70 patients received ruxolitinib as a salvage therapy for SR-cGVHD. Twenty-four weeks after ruxolitinib treatment, the overall response rate (ORR) was 74.3% (52/70), including 34 patients who achieved complete remission (CR) and 18 who achieved partial remission (PR). The main adverse event was cytopenia, which occurred in 51.4% (36/70) of patients. After ruxolitinib treatment, the percentage of CD4 cells increased from 18.20% to 23.22% (<0.001), while the percentages of NK (CD16CD56) cells and regulatory T cells (CD4CD127 CD25) decreased (<0.001, <0.001). Among the B cell subsets, the proportion of total B cells approximately tripled from 3.69% to 11.16% (<0.001). Moreover, we observed a significant increase in IL-10 levels after ruxolitinib treatment (=0.025) and a remarkable decrease in levels of suppression of tumorigenicity 2 (ST2) from 229.90 ng/ml to 72.65 ng/ml. The median follow-up after the initiation of ruxolitinib treatment was 401 (6-1076) days. The estimated one-year overall survival rate of the whole group was 66.0% (54.4-77.6%, 95% CI), and the one-year overall survival rate of patients with mild and moderate cGVHD was 69.6% (57.4-81.8%, 95% CI), which was better than that of patients with severe cGVHD (31.3%, 0.0-66.2%, 95% CI) (=0.002). Patients who achieved a CR and PR achieved better survival outcomes (84.5%, 73.9-95.1%, 95% CI) than those who showed NR to ruxolitinib treatments (16.7%, 0-34.3%, 95% CI) (<0.001). At the final follow-up, cGVHD relapse occurred in six patients after they reduced or continued their ruxolitinib doses. Collectively, our results suggest that ruxolitinib is potentially a safe and effective treatment for SR-cGVHD.
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http://dx.doi.org/10.3389/fimmu.2021.673636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278571PMC
June 2021

Taxonomic description of Pseudomonas rhizovicinus sp. nov., isolated from the rhizosphere of a desert shrub Haloxylon ammodendron.

Antonie Van Leeuwenhoek 2021 Jul 16. Epub 2021 Jul 16.

Center for Grassland Microbiome, State Key Laboratory of Grassland Agro-Ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, 730000, People's Republic of China.

A Gram-negative aerobic bacterium, strain M30-35, was isolated from the rhizosphere of Haloxylon ammodendron in Tengger desert, Gansu province, northwest China. Our previous research indicated that strain M30-35 can promote the growth of ryegrass (Lolium perenne L.). In this study, strain M30-35 was subjected to a polyphasic taxonomic study. Phylogenetic analysis of the 16S rRNA gene and two other housekeeping genes (gyrB, rpoD) showed that strain M30-35 is a member of Pseudomonas anguilliseptica group. The average nucleotide identity (ANI) scores for strains KMM 3042 and FR1439 were 76.5% and 83.7%, respectively, and DNA-DNA hybridization (DDH) were 21.6% and 26.6%, respectively, and the rates were less than the threshold range for species determination. The dominant cellular fatty acids of strain M30-35 were C (22.7%), summed feature 3 (Cω7c and/or Cω6c; 18.5%), summed feature 8 (Cω7c and/or Cω6c; 23.1%). The major polar lipids were diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylglycerol, phospholipid and aminophospholipid and the predominant respiratory quinone was ubiquinone (Q9). On the basis of above data, it can be concluded that strain M30-35 represents a novel species in the genus Pseudomonas, for which the name Pseudomonas rhizovicinus sp. nov. is proposed. The type strain is M30-35 (= MCCC 1K03247 = KCTC 52664).
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http://dx.doi.org/10.1007/s10482-021-01612-9DOI Listing
July 2021

ICP registration with DCA descriptor for 3D point clouds.

Opt Express 2021 Jun;29(13):20423-20439

Widely used in three-dimensional (3D) modeling, reverse engineering and other fields, point cloud registration aims to find the translation and rotation matrix between two point clouds obtained from different perspectives, and thus correctly match the two point clouds. As the most common point cloud registration method, ICP algorithm, however, requires a good initial value, not too large transformation between the two point clouds, and also not too much occlusion; Otherwise, the iteration would fall into a local minimum. To solve this problem, this paper proposes an ICP registration algorithm based on the local features of point clouds. With this algorithm, a robust and efficient 3D local feature descriptor (density, curvature and normal angle, DCA) is firstly designed by combining the density, curvature, and normal information of the point clouds, then based on the feature description, the correspondence between the point clouds and also the initial registration result are found, and finally, the aforementioned result is used as the initial value of ICP to achieve fine tuning of the registration result. The experimental results on public data sets show that the improved ICP algorithm boosts good registration accuracy and robustness, and a fast running speed as well.
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http://dx.doi.org/10.1364/OE.425622DOI Listing
June 2021

Zearalenone promotes apoptosis of mouse Leydig cells by targeting phosphatase and tensin homolog and thus inhibiting the PI3K/AKT signal pathway.

Environ Sci Pollut Res Int 2021 Jul 15. Epub 2021 Jul 15.

College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China.

Zearalenone (ZEA) is a mycotoxin with estrogenic activity whose main effect is to impair the reproductive systems of animals. It leads to reproductive disorders in livestock and thus causes serious losses to agriculture and animal husbandry. This study aims to examine whether ZEA induces toxicity in Leydig cells through the PI3K/AKT signaling pathway and also to investigate the role played by the upstream phosphatase and tensin homolog (PTEN) gene. An adenovirus vector model was constructed to interfere with the PTEN gene to investigate whether ZEA promotes the apoptosis of TM3 cells through the PI3K/AKT pathway. Apoptosis was detected cytometrically and the protein expression levels of PTEN, AKT, p-AKT, Bax, and Bcl-2 were evaluated via western blot analysis. The results show that ZEA induces apoptosis of TM3 cells. PTEN expression is significantly increased (P < 0.01), Bax expression is increased (P < 0.05), AKT and p-AKT expression of anti-apoptotic protein is significantly decreased (P < 0.01), and Bcl-2 protein expression is decreased (P < 0.05) in the ZEA group compared with the control group. In the shRNA+ZEA group, the expression levels of PTEN and Bax proteins are significantly decreased (P < 0.01), AKT protein is significantly increased (P < 0.01), and p-AKT protein is increased (P < 0.05) compared with the ZEA group. This study thus demonstrates that ZEA promotes apoptosis of TM3 cells by targeting PTEN and thus inhibiting the PI3K/AKT signal pathway.
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http://dx.doi.org/10.1007/s11356-021-15282-7DOI Listing
July 2021

Recent advance on chemistry and bioactivities of secondary metabolites from Viburnum plants: An update.

Chem Biodivers 2021 Jul 13. Epub 2021 Jul 13.

Yangzhou University, College of Bioscience and Biotechnology, No.12 Wenhui East Road, Yangzhou City, 225009, Yangzhou, CHINA.

Viburnum species are a group of small trees or shrubs that are of great ornamental and medicinal values. Some of them have been used for a long time both as conventional and ethnic medicine. Viburnum fruits, eaten in fresh and processed forms, have been revealed to contain various health-promoting nutrients. With the increasing research on Viburnum plants, they are considered to be an abundant resource of bioactive natural products possessing diverse pharmacological properties and unique chemical structures, that is powerfully proved by the existence of structurally novel vibsane-type diterpenoids which only occur in Viburnum species, newly discovered lignan constituents with unusual side chains and other noteworthy natural components. This review describes 185 new and 228 known secondary metabolites from Viburnum genus between 2008 and 2020, including their chemical structures, sources and bioactivities, and highlights the corresponding structure-activity relationships.
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http://dx.doi.org/10.1002/cbdv.202100404DOI Listing
July 2021

The effect of laparoscopic sleeve gastrectomy on type 2 diabetes remission outcomes in patients with body mass index higher than 25 kg/m but lower than 32.5 kg/m.

Asian J Surg 2021 Jul 7. Epub 2021 Jul 7.

Department of Weight Loss and Metabolic Surgery, China-Japan Union Hospital of Jilin University, Jilin, China. Electronic address:

Background: The effect of laparoscopic sleeve gastrectomy (LSG) in the treatment of type 2 diabetes (T2D) patients with body mass index (BMI is calculated by dividing weight in kilograms by height in meters squared) higher than 25 kg/m but lower than 32.5 kg/m, especially in East Asian population characterized by abdominal obesity, are still unclear. This study aims to explore the effect of LSG in T2D patients with BMI higher than 25 kg/m but lower than 32.5 kg/m.

Methods: A total of 49 T2D patients with BMI(25-32.5 kg/m) treated successfully with LSG were included in our study. The effect of LSG on T2D remission outcomes at 12 and 24 months after operation was analyzed.

Results: All patients were treated successfully with LSG without conversion. The mean preoperative body weight,BMI, fasting plasma glucose, glycosylated hemoglobin (A1c) and fasting C-peptide were 81.7 ± 10.0 kg, 29.1 ± 2.4 kg/m, 10.4 ± 3.9 mmol/L,8.2 ± 1.5%, and 2.3 ± 1.1 nmol/L,respectively.The age, duration of diabetes and ABCD score were 48.6 ± 9.6 years,6.6 ± 5.1 years, and 2.9 ± 1.5. The mean fasting plasma glucose,A1c, and C-peptide levels were significantly decreased at 12 and 24 months after operation. At postoperative 24 months, 18 out of 49 patients (36.7%) reached diabetes complete remission (A1c levels≤6.0%).14 out of 49 patients (28.6%) reached partial remission (6.0% < A1c levels<6.5%). 8 out of 49 patients (16.3%) reached notable improvement (6.5% < A1c levels<7%). At 24 months after LSG, the complete remission rate of T2D patients with a BMI of 25-27.5 kg/m was 35.3%, the complete remission rate of patients with a BMI of 27.5-30 kg/m was 11.1%, and the complete remission rate of patients with a BMI of 30-32.5 kg/m was 47.8%.At postoperative 24 months, the complete remission rate of T2D patients with ABCD score≤2 was 5.0%, the complete remission rate of patients with ABCD score 3 to 4 was 52.4%, and the complete remission rate of patients with ABCD score≥5 was 75.0%.

Conclusion: Our study demonstrates that LSG could result in a significant effect on T2D in patients with BMI 30-32.5 kg/m. In addition, our study indicates that higher ABCD score can predict a better diabetes remission outcome in diabetes patients with BMI ≤32.5 kg/m.
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http://dx.doi.org/10.1016/j.asjsur.2021.06.001DOI Listing
July 2021

Peg-interferon alpha add-on Tenofovir disoproxil fumarate achieved more HBsAg loss in HBeAg-positive chronic hepatitis B naïve patients.

J Viral Hepat 2021 Jul 6. Epub 2021 Jul 6.

Department of Infectious Diseases, Research Laboratory of Clinical Virology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Several studies have showed that combining peg-interferon alpha (Peg-IFNα) with nucleotide analogues has complementary effects in chronic hepatitis B (CHB), but the optimal regimen and potential mechanisms remain unclear. This was a prospective, longitudinal and multicentre clinical trial (NCT03013556). HBeAg-positive CHB naïve patients were randomly assigned to three groups: tenofovir disoproxil fumarate (TDF) monotherapy for 96 weeks, TDF alone for 48 weeks and sequentially Peg-IFNα added for 48 weeks, TDF de novo combination with Peg-IFNα for 48 weeks then TDF alone for 48 weeks. The primary endpoint was HBeAg seroconversion at week 96 and HBsAg loss as the secondary endpoint. Furthermore, the levels of 12 cytokines in serum were assessed at different time points. A total of 133 patients were included in the analysis. The rates of HBeAg seroconversion at 96 weeks were not significant different among the three groups (p = 0.157). Interestingly, patients in the Peg-IFNα add-on group showed markedly lower HBsAg level compared with the other two groups at week 96. In addition, only three patients in the Peg-IFNα add-on group achieved HBsAg loss. For the following 24 weeks from week 96, no HBsAg reappearance in the three patients and no new patients with HBsAg loss were observed in the three groups. Serum cytokine analysis showed that the baseline level of interferon-inducible protein-10 (IP-10) was strongly higher in HBeAg conversion patients and HBsAg loss patients. Compared with de novo combination and TDF alone, the addition of Peg-IFNα in TDF-treated group might be an effective strategy for HBsAg loss in HBeAg-positive CHB naïve patients.
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http://dx.doi.org/10.1111/jvh.13571DOI Listing
July 2021

Octadecylimidazolium ionic liquids-functionalized carbon dots and their precursor co-immobilized silica as hydrophobic chromatographic stationary phase with enhanced shape selectivity.

Talanta 2021 Oct 13;233:122513. Epub 2021 May 13.

CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China; College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China. Electronic address:

In this work, 1-vinyl-3-octadecylimidazolium bromide ionic liquids ([CVIm]Br) and their derived carbon dots (ImCCDs) were prepared, [CVIm]Br and ImCCDs were grafted on the silica to obtain Sil-ImC and Sil-ImCCDs, respectively, and they were also co-grafted on silica which named Sil-ImC/CDs. Compared with Sil-ImC and Sil-ImCCDs columns, Sil-ImC/CDs column exhibited enhanced selectivity for separation of tetracyclic/tricyclic polycyclic aromatic hydrocarbon (PAH) isomers, and butylbenzene isomers in reversed-phase liquid chromatography, which may be due to the synergistic effect between ImCCDs and [CVIm]Br, the π-π interaction between imidazolium and analytes, etc. Meanwhile, the retention behavior of Sil-ImC/CDs was further evaluated and compared with the commercial C column using different classes of analytes, including standard test mixtures of Tanaka, Engelhardt, SRM869b, SRM870. The results demonstrated that co-grafted column exhibited superior separation performance. And this column was applied to determine the contents of calycosin-7-glucoside, ononin, calycosin and formononetin in the extract of Radix Astragali, which were found that the concentration was 0.25 mg mL, 0.15 mg mL, 0.13 mg mL and 0.30 mg mL, respectively.
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http://dx.doi.org/10.1016/j.talanta.2021.122513DOI Listing
October 2021

Huiyang Shengji Extract Improve Chronic Nonhealing Cutaneous through the TGF-1/Smad3 Signaling Pathway.

Evid Based Complement Alternat Med 2021 9;2021:8881565. Epub 2021 Jun 9.

Beijing Institute of TCM, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, 23 Gallery Backstreet, Dongcheng District, Beijing 100010, China.

Chronic nonhealing cutaneous wounds are a thorny problem in the field of surgery because of their prolonged and unhealed characteristics. Huiyang Shengji extract (HSE) is an extract of traditional Chinese medicine prescription for treating chronic wounds. This study aims to investigate the regulation of M1 macrophages on fibroblast proliferation and secretion and the intervention mechanism of Huiyang Shengji extract. We found that the effects of HSFs stimulated with paracrine factors from M1 macrophages were as follows: the proliferation of HSFs was reduced, the expression of MKI-67 was downregulated, and the content and gene expression of the inflammation factors and fibroblast MMPs were increased, while the content and gene expression of TIMP-1 are decreased, the content of human fibroblasts secreting type I collagen (COL1A1) and type III collagen (COL3A1) was decreased, and the TGF-1/Smad3 signaling pathway was inhibited. Interestingly, HSE inhibited these effects of M1 macrophages on human fibroblasts after the intervention, and the inhibitory effect was related to the concentration. In conclusion, M1 macrophages caused changes in HSFs and secretion, while HSE has a specific regulatory effect on the proliferation and secretion of fibroblasts caused by M1 macrophages.
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http://dx.doi.org/10.1155/2021/8881565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208873PMC
June 2021

Data Augmentation of Automotive LIDAR Point Clouds under Adverse Weather Situations.

Sensors (Basel) 2021 Jun 30;21(13). Epub 2021 Jun 30.

Electrical and Computer Engineering, Technical University of Munich, Theresienstr. 90, D-80333 München, Germany.

In contrast to previous works on data augmentation using LIDAR (Light Detection and Ranging), which mostly consider point clouds under good weather conditions, this paper uses point clouds which are affected by spray. Spray water can be a cause of phantom braking and understanding how to handle the extra detections caused by it is an important step in the development of ADAS (Advanced Driver Assistance Systems)/AV (Autonomous Vehicles) functions. The extra detections caused by spray cannot be safely removed without considering cases in which real solid objects may be present in the same region in which the detections caused by spray take place. As collecting real examples would be extremely difficult, the use of synthetic data is proposed. Real scenes are reconstructed virtually with an added extra object in the spray region, in a way that the detections caused by this obstacle match the characteristics a real object in the same position would have regarding intensity, echo number and occlusion. The detections generated by the obstacle are then used to augment the real data, obtaining, after occlusion effects are added, a good approximation of the desired training data. This data is used to train a classifier achieving an average F-Score of 92. The performance of the classifier is analyzed in detail based on the characteristics of the synthetic object: size, position, reflection, duration. The proposed method can be easily expanded to different kinds of obstacles and classifier types.
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http://dx.doi.org/10.3390/s21134503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271385PMC
June 2021

The formation, determination and health implications of polar compounds in edible oils: Current status, challenges and perspectives.

Food Chem 2021 Jun 24;364:130451. Epub 2021 Jun 24.

College of Food Science and Engineering, Northwest A&F University, 22 Xinong Road, Yangling 712100, Shaanxi, PR China. Electronic address:

To effectively control the quality of edible oil, polar compounds in edible oils have been studied extensively in the past few decades, particularly in the field of frying. This article critically reviews the formation, determination, and health implications of the polar compounds in edible oils via comprehensive literature research. The challenges and perspectives of polar compounds in edible oils are also discussed. Three chemical reactions, including oxidation, hydrolysis, and polymerization, elaborate polar compound formation. Many techniques are used to determine the total polar compound content of edible oils, with comparative analysis; Fourier transform infrared technique is a relatively ideal method. A major obstacle for nutritional studies focused on polar compounds formed during frying is that few pure compounds have been quantified. To inhibit the formation of the polar compounds effectively, investigations into the applications of enzymatic method in developing new lipophilized antioxidants may be a new direction in research.
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http://dx.doi.org/10.1016/j.foodchem.2021.130451DOI Listing
June 2021

Knockdown of enhancer of rudimentary homolog expression attenuates proliferation, cell cycle and apoptosis of melanoma cells.

Melanoma Res 2021 08;31(4):309-318

Department of Dermatology, Xiangya Hospital, Changsha, Hunan, People's Republic of China. Changsha, Hunan, China.

Early stage or localized melanoma can be surgically resected with satisfactory outcome, whereas advanced malignant melanoma responds to treatment poorly and has a negative prognosis even after surgery, radiotherapy and other comprehensive treatments. Gene therapy targeting various biological signaling pathways has become an increasingly popular area in melanoma research. However, for gene therapy success, it is important to reveal the molecular mechanisms of melanoma tumorigenesis and development. The present study examined the effects of downregulating enhancer of rudimentary homolog (ERH) expression on the proliferation, metastasis and cell cycle of melanoma cells. ERH expression levels in melanoma tissues and cells were determined. Then, ERH gene expression in melanoma cell lines was downregulated or overexpressed by the lentiviral RNA interference technique. Furthermore, we performed cell counting kit-8, clone formation, scratch, transwell migration, subcutaneous tumorigenesis and venous metastasis assays as well as carried out flow cytometry analysis to explore the effects of ERH expression on cell proliferation, cell cycle, apoptosis and metastasis. We found that ERH expression in melanoma tissues and cells was markedly higher than in normal melanin nevus. Suppressing ERH expression by RNA interference in melanoma A375, WM35 and SK28 cell lines inhibited their proliferation and induced cell apoptosis. The cell cycle was also found to be blocked in the G1 phase. However, the metastatic properties of melanoma cells in vitro and in vivo remained largely unaltered by ERH knockdown. Our results show that ERH expression is increased in melanoma. Meanwhile, the proliferation and cell cycle transformation abilities are impaired potentially by downregulating the ERH expression in melanoma cells. Therefore, targeting ERH might serve as a novel therapeutic approach for malignant melanoma.
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http://dx.doi.org/10.1097/CMR.0000000000000747DOI Listing
August 2021

Nonionic surfactants based hydrophobic deep eutectic solvents for liquid-liquid microextraction of Sudan dyes in tomato chili sauces.

Food Chem 2021 Jun 16;364:130373. Epub 2021 Jun 16.

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education), and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. Electronic address:

A new type of high-density hydrophobic deep eutectic solvents (DESs) were synthesized with nonionic surfactants as hydrogen bond acceptors and hexafluoroisopropanol (HFIP) as hydrogen bond donor. Brij-35 was selected as the optimal nonionic surfactant for the preparation of Brij-35-HFIP-DES (molar ratio 1:20). A vortex-assisted DES-based liquid-liquid microextraction method was proposed for determination of Sudan dyes in tomato chili sauces. The whole pretreatment process only needs 5 min and 1.1 mL of organic solvent. The method with HPLC-DAD shows high efficiency (enrichment factors 89-176 and extraction rates 61.0-74.6%) and good performance with linearity (R ≥ 0.9997) in 0.04-2 μg g range, detection limits of 0.0045-0.0118 μg g, recoveries of 91.6-104.5% and intra-/inter-day precision below 8.0%. A "DES in water in DES" aggregate microstructure was observed in DES-rich phase. The proposed method is simple, quick, eco-friendly, and suits for the efficient extraction and accurate determination of Sudan dyes in tomato chili sauces.
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http://dx.doi.org/10.1016/j.foodchem.2021.130373DOI Listing
June 2021

Prognostic value of lymphoid marker CD7 expression in acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplantation in first morphological complete remission.

Int J Hematol 2021 Jun 26. Epub 2021 Jun 26.

National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Shizi Street 188, Suzhou, 215006, China.

Although defined as a lymphoid surface marker, CD7 is aberrantly expressed on a subtype of acute myeloid leukemia cells and appears to be associated with an inferior response to chemotherapy. Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative modality but no data has been reported in CD7-positive AML patients. We performed a retrospective analysis involving 141 AML patients who underwent allo-HCT in first morphological complete remission (CR1). The results showed that CD7-positive AML patients had a poor 2-year overall survival (64.5% vs 82.0%, P = 0.040), relapse-free survival (RFS) (56.5% vs 79.4%, P = 0.005), and higher cumulative incidence of relapse (27.0% vs 9.7%, P = 0.003) post-HCT. In addition, expression of CD7 was related to RAS and RUNX1 mutation, and high residual disease level pre-HCT. Multivariate analyses showed CD7 expression at diagnosis was an independent risk factor for RFS (P = 0.016, HR = 0.418) and relapse (P = 0.014, HR = 0.307). We concluded that for AML patients in CR1, CD7 is a negative predictor for allo-transplant outcomes.
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http://dx.doi.org/10.1007/s12185-021-03182-yDOI Listing
June 2021

Synthesis of an AIEgen functionalized cucurbit[7]uril for subcellular bioimaging and synergistic photodynamic therapy and supramolecular chemotherapy.

Chem Sci 2021 Apr 21;12(22):7727-7734. Epub 2021 Apr 21.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau Taipa Macau 999078 China

Aggregation-induced emission (AIE) based fluorophores (AIEgens) have attracted increasing attention for biomedical applications due to their unique optical properties. Here we report an AIE photosensitizer functionalized CB[7], namely AIECB[7], which could spontaneously self-assemble into nanoaggregates in aqueous solutions. Interestingly, the carbonyl-lace of CB[7] may potentially act as a proton acceptor in an acidic environment to fine-tune the fluorescence and singlet oxygen generation of AIECB[7] nanoaggregates by regulating the inner stacking of AIEgens. Additionally, benefiting from the guest-binding properties of CB[7], oxaliplatin was included into AIECB[7] nanoaggregates for combined photodynamic therapy and supramolecular chemotherapy. To show the modular versatility of this supramolecular system, a hypoxia-activatable prodrug banoxantrone (AQ4N) was loaded into AIECB[7] nanoaggregates, which exhibited synergistic antitumor effects on a multicellular tumor spheroid model (MCTS). This work not only provides AIECB[7] for versatile theranostic applications, but also offers important new insights into the design and development of macrocycle-conjugated AIE materials for diverse biomedical applications.
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http://dx.doi.org/10.1039/d1sc01139aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188462PMC
April 2021

Identification of differentially expressed proteins involved in fetal scarless wound healing using a rat model of cleft lip.

Mol Med Rep 2021 Aug 24;24(2). Epub 2021 Jun 24.

Department of Plastic and Reconstructive Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China.

In early pregnancy, fetal skin wounds can heal quickly and undergo a transition period from scarless healing to scar formation. The aim of the present study was to identify potential biomarkers associated with scarless repair of cleft lips, in order to determine the intrinsic factors leading to scar formation in embryonic tissue. A stable model of cleft lip was established using microsurgery by constructing a wedge‑shaped cleft lip‑like defect in fetal rats at gestational age (GA) 16.5 and GA18.5. The GA16.5 and GA18.5 groups were used to model scarless healing and scar formation, respectively. The fetuses were returned to the uterus following surgery, then removed 72 h after the procedure. Macroscopic observation of the cleft defect and histological examination were carried out. Reverse transcription‑quantitative (RT‑q) PCR and parallel reaction monitoring (PRM) were used to detect mRNA and protein expression levels, respectively. The upper‑left lip completely healed 72 h after surgery in the GA16.5 group of fetal rats. However, this was not the case in the GA18.5 group. Histological examination indicated new follicles visible under the epidermis of the scarless group (GA16.5). Scarring was visible on the upper‑left cleft lip wound of the fetal rats in the GA18.5 group. The expression of some growth and pro‑inflammatory factors, including TNF‑α, were also different between two groups. Label‑free quantification was used to identified differentially expressed proteins and five differentially expressed proteins (Smad4, Fabp5, S100a4, S100a8 and S100a9) were identified. The relative expression of these molecules at the mRNA and protein levels were measured using RT‑qPCR and PRM. These molecules may represent potential biomarkers for the scarless repair of fetal rat cleft lip wounds.
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http://dx.doi.org/10.3892/mmr.2021.12235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8240453PMC
August 2021

CRISPR Adventures in China.

Authors:
Caixia Gao Jia Chen

CRISPR J 2021 Jun;4(3):304-306

Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai, PR China; and Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, PR China.

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http://dx.doi.org/10.1089/crispr.2021.29129.gaoDOI Listing
June 2021

What Are the Different Measures of Mobility Telling Us About Surface Transportation CO Emissions During the COVID-19 Pandemic?

J Geophys Res Atmos 2021 Jun 1;126(11):e2021JD034664. Epub 2021 Jun 1.

Environmental Sensing and Modeling Technical University of Munich (TUM) Munich Germany.

The COVID-19 pandemic led to widespread reductions in mobility and induced observable changes in atmospheric emissions. Recent work has employed novel mobility data sets as a proxy for trace gas emissions from traffic by scaling CO emissions linearly with those near-real-time mobility data. Yet, there has been little work evaluating these emission numbers. Here, we systematically compare these mobility data sets to traffic data from local governments in seven diverse urban and national/state regions to characterize the magnitude of errors that result from using the mobility data. We observe differences in excess of 60% between these mobility data sets and local traffic data. We could not find a general functional relationship between the mobility data and traffic flow over all the regions and observe higher deviations from using such general relationships than the original data. Finally, we give an overview of the potential errors that come from estimating CO emissions using (mobility or traffic) activity data. Future work should be cautious while using these mobility metrics for emission estimates.
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http://dx.doi.org/10.1029/2021JD034664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206752PMC
June 2021

Machine learning-based prediction of survival prognosis in cervical cancer.

BMC Bioinformatics 2021 Jun 16;22(1):331. Epub 2021 Jun 16.

Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Bioengineering College, Chongqing University, Chongqing, 400044, People's Republic of China.

Background: Accurately forecasting the prognosis could improve cervical cancer management, however, the currently used clinical features are difficult to provide enough information. The aim of this study is to improve forecasting capability by developing a miRNAs-based machine learning survival prediction model.

Results: The expression characteristics of miRNAs were chosen as features for model development. The cervical cancer miRNA expression data was obtained from The Cancer Genome Atlas database. Preprocessing, including unquantified data removal, missing value imputation, samples normalization, log transformation, and feature scaling, was performed. In total, 42 survival-related miRNAs were identified by Cox Proportional-Hazards analysis. The patients were optimally clustered into four groups with three different 5-years survival outcome (≥ 90%, ≈ 65%, ≤ 40%) by K-means clustering algorithm base on top 10 survival-related miRNAs. According to the K-means clustering result, a prediction model with high performance was established. The pathways analysis indicated that the miRNAs used play roles involved in the regulation of cancer stem cells.

Conclusion: A miRNAs-based machine learning cervical cancer survival prediction model was developed that robustly stratifies cervical cancer patients into high survival rate (5-years survival rate ≥ 90%), moderate survival rate (5-years survival rate ≈ 65%), and low survival rate (5-years survival rate ≤ 40%).
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http://dx.doi.org/10.1186/s12859-021-04261-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8207793PMC
June 2021

The role and related microbial processes of Mn-dependent anaerobic methane oxidation in reducing methane emissions from constructed wetland-microbial fuel cell.

J Environ Manage 2021 Sep 10;294:112935. Epub 2021 Jun 10.

College of Civil Engineering, Sichuan Agricultural University, Dujiangyan, 611830, PR China.

Anaerobic oxidation of methane (AOM) plays an important role in global carbon cycle and greenhouse gas emission reduction. In this study, an effective green technology to reduce methane emissions was proposed by introducing Mn-dependent anaerobic oxidation of methane (Mn-AOM) and microbial fuel cell (MFC) technology into constructed wetland (CW). The results indicate that the combination of biological methods and bioelectrochemical methods can more effectively control the methane emission from CW than the reported methods. The role of dissimilated metal reduction in methane control in CW and the biochemical process associated with Mn-AOM were also investigated. The results demonstrated that using Mn ore as the matrix and operating MFC effectively reduced methane emissions from CW, and higher COD removal rate was obtained in CW-MFC (Mn) during the 200 days of operation. Methane emission from CW-MFC (Mn) (53.76 mg/m/h) was 55.61% lower than that of CW (121.12 mg/m/h). The highest COD removal rate (99.85%) in CW-MFC (Mn) was obtained. As the dissimilative metal-reducing microorganisms, Geobacter (5.10%) was found enriched in CW-MFC (Mn). The results also showed that the presence of Mn ore was beneficial to the biodiversity of CW-MFCs and the growth of electrochemically active bacteria (EAB) including Proteobacteria (35.32%), Actinobacteria (2.38%) and Acidobacteria (2.06%), while the growth of hydrogenotrophic methanogens Methanobacterium was effectively inhibited. This study proposed an effective way to reduce methane from CW. It also provided reference for low carbon technology of wastewater treatment.
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http://dx.doi.org/10.1016/j.jenvman.2021.112935DOI Listing
September 2021

Giant retroperitoneal myxoma: A case report and literature review.

Int J Surg Case Rep 2021 Jul 29;84:106055. Epub 2021 May 29.

Department of Radiology,The Affiliated Hospital of Guizhou Medical university, Guiyang, China.

Introduction And Importance: Myxoma is a benign tumor and is mesenchymal in origin. Myxomas of the retroperitoneum are extremely rare entities.

Case Presentation: We here report a case of a 67-year-old male who presented with progressive abdominal distention for 3 years. Laboratory investigations revealed a reduction in erythrocytes, lymphocytes, hemoglobin, and an elevation in carbohydrate antigen 19-9. Imaging findings showed a multilocular cystic mass in the right abdomen with thin septa and internal calcifications. Laparotomy revealed that the mass had arisen from the retroperitoneum and the histological study suggested the diagnosis of myxoma.

Discussion: Myxoma features as a "cystic mass" in imaging studies. Therefore, the possibility of a cystic lymphangioma, cystic mesothelioma and myxoma should be considered when a multicystic lesion in the retroperitoneal space is observed. Due to the rarity of retroperitoneal myxomas and lack of specific manifestations and diagnostic methods, preoperative diagnosis is often delayed or incorrect. And until now, only a few cases of retroperitoneal myxoma have been reported.

Conclusion: The report will increase the understanding of the diagnosis and treatment of retroperitoneal myxomas. A brief review of the related literature was also carried out.
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http://dx.doi.org/10.1016/j.ijscr.2021.106055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209073PMC
July 2021

Genetic characterizations of spp. from pet rodents indicate high zoonotic potential of pathogens from chinchillas.

One Health 2021 Dec 24;13:100269. Epub 2021 May 24.

Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.

spp. are common protozoan pathogens in mammals. With pet rodents being integrated into modern life, the potential roles of them in transmitting parasites to humans need assessments. In the present study, we examined the occurrence of spp. in pet rodents in Guangdong, south China. A total of 697 fecal samples were collected from 11 species of rodents in seven pet shops, one pet market and one farm. spp. were identified by PCR analysis of the small subunit rRNA gene. An overall infection rate of 36.9% (257/697) was obtained, with infection rates varying from 9.3% in chinchillas, 52.3% in guinea pigs, 57.1% in squirrels, to 68.4% in cricetid animals. Nine species and genotypes were identified, including (in 129 guinea pigs), (in 34 hamsters), (in 32 guinea pigs), hamster genotype (in 30 hamsters), (in 24 chinchillas and squirrels), (in 2 chinchillas), ferret genotype (in 2 chipmunks), (in 1 hamster and 1 guinea pig), and chipmunk genotype V (in 1 chinchilla and 1 chipmunk). Sequence analysis of the 60 kDa glycoprotein gene identified three subtype families of , including family XIId in 15 chinchillas, XIIa in 5 chinchillas, and a new subtype family (XIIi) in 1 squirrel. The identification of and in pet rodents suggests that these animals, especially chinchillas, could serve as reservoirs of human-pathogenic spp. Hygiene should be practiced in the rear and care of these animals, and One Health measures should be developed to reduce the occurrence of zoonotic infections due to contact with pet rodents.
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http://dx.doi.org/10.1016/j.onehlt.2021.100269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170418PMC
December 2021

A Prospective Investigation of Bispecific CD19/22 CAR T Cell Therapy in Patients With Relapsed or Refractory B Cell Non-Hodgkin Lymphoma.

Front Oncol 2021 25;11:664421. Epub 2021 May 25.

Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Background: The use of T cells expressing chimeric antigen receptor (CAR T) engineered to target CD19 constitutes breakthrough treatment for relapsed or refractory B cell non-Hodgkin lymphoma (R/R B-NHL). Despite improved outcomes, high relapse rate remains a challenge to overcome. Here, we report the clinical results and the pharmacokinetics of bispecific CD19/22 CAR T in patients with R/R B-NHL.

Methods: We performed a prospective, single-arm study of bispecific CD19/22 CAR T cells in R/R B-NHL. We analyzed the safety and efficacy and investigated the kinetic profiles of the CAR T cells. CAR transgene levels were measured using quantitative polymerase chain reaction, and correlation analyses of pharmacodynamic markers and product characteristics, disease conditions, clinical efficacy and adverse events were performed.

Results: From August 2017 to September 2020, a total of 32 patients with CD19/22 CAR T administration were analyzed. The overall response rate was 79.3%, and the complete response rate was 34.5%. The progression-free survival (PFS) and overall survival (OS) rates at 12 months were 40.0% and 63.3%, respectively. Among patients who had a CR at 3 months, the PFS and OS rates at 12 months were 66.7% and 100%, respectively. Severe cytokine release syndrome (sCRS) (grade 3 and higher) occurred in nine patients (28.1%). Grade 3 or higher neurologic events occurred in four patients (12.5%). One patient died from irreversible severe CRS-associated acute kidney injury. Long-term CAR T cells persistence correlated with clinical efficacy (133 days vs 22 days, P = 0.004). Patients treated with more than three prior therapies and presenting extranodal organ involvement had lower maximal concentration (C) values than other patients. Responders had higher C and area under the curve values than non-responders. Tumour burden and C were potentially associated with the severity of CRS.

Conclusions: This study demonstrates the safety and potential clinical efficacy of bispecific CD19/22 CAR T cells in patients with R/R B-NHL and highlights the importance of measuring kinetic parameters in PB to predict efficacy and safety in clinical applications of CAR T cell therapy.

Clinical Trial Registration: https://www.clinicaltrials.gov/ct2/show/NCT03196830, identifier NCT03196830.
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http://dx.doi.org/10.3389/fonc.2021.664421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185372PMC
May 2021

Upper Lumbar Intradural Disc Herniation: A Rare Case Report and Etiologic Analysis.

J Pain Res 2021 27;14:1475-1481. Epub 2021 May 27.

Department of Orthopaedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, People's Republic of China.

Background: Intradural disc herniation (IDH) is a rare type of disc degeneration that infrequently affects the upper lumbar spine. Pre- and intraoperative diagnosis and surgical management of IDH are challenging. The present case study provides insight into these aspects of upper lumbar IDH and discusses possible mechanisms.

Case Description: A 63-year-old female with a history of chronic lower back and leg pain presented with an acute lumbar sprain that had occurred 1 month prior. The pain progressed and spread to the front of the left thigh, which affected her ability to lift her leg when ascending/descending stairs. Sagittal gadolinium-enhanced magnetic resonance imaging (MRI) revealed a disc protruding into the ventral dural sac showing a hawk-beak sign, and the posterior edge of the disc annulus and local posterior longitudinal ligament was broken. Total L2 laminectomy was performed, and the dorsal side of the dural sac was exposed and incised to enable exploration of the ventral side of the dura. We found two free fragments protruding into the inner wall of the dura through the left ventral dura mater defect. After carefully and completely removing the mass, we repaired the defect and performed internal fixation. Postoperative pathologic analysis confirmed that the mass was nucleus pulposus tissue from the degenerated disc. The patient's pain significantly improved after surgery, and she was able to walk normally at the 1-month follow-up.

Conclusion: Upper lumbar IDH is an extremely rare type of disc degeneration. An enhanced MRI scan can provide diagnostic evidence, but the final diagnosis requires surgical exploration of the path of herniation and pathologic examination of the mass lesion.
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http://dx.doi.org/10.2147/JPR.S297304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166278PMC
May 2021

Molecular Characterization of Chitin Synthase Gene in (Boisduval) and Its Response to Sublethal Concentrations of an Insecticide.

Insects 2021 May 28;12(6). Epub 2021 May 28.

School of Life Sciences, Nanchang University, Nanchang 330031, China.

The carmine spider mite, (Boisduval), is one of the most important acarine pest species. At present, its control remains primarily dependent on using various chemical insecticides/acaricides in agricultural crops worldwide. To clarify the mechanism whereby responds to insecticide exposure, we identified the chitin synthase 1 gene () and then explored the gene expression levels of at different developmental stages of . We also investigated the effects of sublethal concentrations of diflubenzuron on the toxicities and survivals of eggs and larvae as well as expression levels. The full-length cDNA sequence contains an open reading frame (ORF) of 4881 nucleotides that encoded for a 1474 amino acid residues protein. The predicted TcCHS1 protein had a molecular mass of 168.35 kDa and an isoelectric point of 6.26, and its amino acid sequence contained all the signature motifs (EDR, QRRRW and TWGTR) of chitin synthases. The results of phylogenetic analyses demonstrated that the putative CHS1 amino acid sequence of revealed high similarities with chitin synthases in other insects and mites. Additionally, at the molecular level, transcriptional analysis by real-time quantitative PCR in different developmental stages of revealed that mRNA was expressed in all stages, and highest in eggs and female adults, but lowest in deutonymphs. Furthermore, the results of toxicity bioassays indicated that diflubenzuron treatment resulted in high mortality rates in eggs and larvae of . The mRNA expression levels of from the eggs and larvae of were up-regulated in response to sublethal concentrations of diflubenzuron exposures. Together, all these results demonstrate that diflubenzuron has ovicidal and larvicidal effects and may play an important role in the growth and development of and may disrupt the chitin biosynthesis, thereby controlling populations.
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http://dx.doi.org/10.3390/insects12060501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227100PMC
May 2021

A case of tripterygium glycosides-associated AGEP-like drug reaction combined with bullous pemphigoid.

Dermatol Ther 2021 May 31:e15012. Epub 2021 May 31.

Shanghai Skin disease Hospital, Tongji University School of Medicine, Shanghai, China.

Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous drug reaction. Bullous pemphigoid (BP) is an acquired autoimmune disease that might be associated with drugs. There is currently no report of tripterygium glycosides (TG)-induced AGEP-like lesions combined with BP. A 66-year-old male with a 20-year history of psoriasis was prescribed oral TG at 1 mg/kg, three times a day, due to aggravated psoriasis. Seven days later, erythemas, and blisters appeared. After another 3 days, there were two types of blisters: (1) numerous small tension blisters with a lot of neutrophils on the top similar to AGEP combined with BP; (2) a BP. After intravenous injection of methylprednisolone and gamma globulin, the lesions were controlled. This patient developed two types of lesions, including one similar to AGEP combined BP (AGEP-like) and a BP. It is a rare drug reaction induced by TG.
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http://dx.doi.org/10.1111/dth.15012DOI Listing
May 2021

Low-Power Memristive Logic Device Enabled by Controllable Oxidation of 2D HfSe for In-Memory Computing.

Adv Sci (Weinh) 2021 May 29:e2005038. Epub 2021 May 29.

Wuhan National Laboratory for Optoelectronics, School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan, 430074, China.

Memristive logic device is a promising unit for beyond von Neumann computing systems and 2D materials are widely used because of their controllable interfacial properties. Most of these 2D memristive devices, however, are made from semiconducting chalcogenides which fail to gate the off-state current. To this end, a crossbar device using 2D HfSe is fabricated, and then the top layers are oxidized into "high-k" dielectric HfSe O via oxygen plasma treatment, so that the cell resistance can be remarkably increased. This two-terminal Ti/HfSe O /HfSe /Au device exhibits excellent forming-free resistive switching performance with high switching speed (<50 ns), low operation voltage (<3 V), large switching window (10 ), and good data retention. Most importantly, the operation current and the power consumption reach 100 pA and 0.1 fJ to 0.1 pJ, much lower than other HfO based memristors. A functionally complete low-power Boolean logic is experimentally demonstrated using the memristive device, allowing it in the application of energy-efficient in-memory computing.
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http://dx.doi.org/10.1002/advs.202005038DOI Listing
May 2021

Keeping up with the pace of international doctoral education reform: China implements the application-assessment system.

Postgrad Med J 2021 May 26. Epub 2021 May 26.

Department of Psychiatry, Shantou University Mental Health Center, Shantou, China.

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http://dx.doi.org/10.1136/postgradmedj-2021-140205DOI Listing
May 2021

Do Infant Faces Maintain the Attention of Adults With High Avoidant Attachment?

Front Psychol 2021 7;12:631751. Epub 2021 May 7.

School of Psychology, Guizhou Normal University, Guiyang, China.

We investigated whether adults have attentional bias toward infant faces, whether it is moderated by infant facial expression, and the predictive effect of the adult attachment state on it. One hundred unmarried nulliparous college students [50 men and 50 women; aged 17-24 years ( = 19.70, SD = 1.35)] were recruited. Each completed a self-report questionnaire-the Chinese version of the State Adult Attachment Measure (SAAM), and a dot-probe task with a stimulus presentation duration of 500 ms, which used 192 black-and-white photographs of 64 people (32 infants and 32 adults; each person displayed three expressions: happy, neutral, and sad) as the experimental stimuli. The results showed that, at the duration of 500 ms, individuals' attentional bias toward infant faces disappeared, regardless of the facial expression. However, when the interaction between avoidant attachment state and face was controlled, the attentional bias was significant again, and the avoidant attachment state negatively predicted individuals' attentional bias toward infant faces. This indicates that at the suprathreshold stage, there are individual differences in the attentional bias toward infant faces, and high avoidant attachment will weaken individuals' attentional bias toward infant faces. This study advances previous studies that focused only on individuals' attention to infant faces occurring at the early processing stage of attention. The results provide direction for interventions; specifically, changing the attachment state of avoidant individuals can affect their attention to infants, which may promote the establishment of parent-child relationships.
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http://dx.doi.org/10.3389/fpsyg.2021.631751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137973PMC
May 2021
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