Ji-Ming Ye

Ji-Ming Ye

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Ji-Ming Ye

Ji-Ming Ye

Publications by authors named "Ji-Ming Ye"

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Bouchardatine analogue alleviates NAFLD/NASH in high fat fed mice via blunting ATP synthase activity.

Br J Pharmacol 2019 May 21. Epub 2019 May 21.

Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bph.14713
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http://dx.doi.org/10.1111/bph.14713DOI Listing
May 2019

Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice.

Acta Pharmacol Sin 2019 Apr 18. Epub 2019 Apr 18.

Center for Drug Safety Evaluation and Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

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http://dx.doi.org/10.1038/s41401-019-0220-1DOI Listing
April 2019

Bouchardatine suppresses rectal cancer in mice by disrupting its metabolic pathways via activating the SIRT1-PGC-1α-UCP2 axis.

Eur J Pharmacol 2019 Apr 24;854:328-337. Epub 2019 Apr 24.

Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.

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http://dx.doi.org/10.1016/j.ejphar.2019.04.029DOI Listing
April 2019

Matrine Protects Against MCD-Induced Development of NASH via Upregulating HSP72 and Downregulating mTOR in a Manner Distinctive From Metformin.

Front Pharmacol 2019 24;10:405. Epub 2019 Apr 24.

Lipid Biology and Metabolic Disease Laboratory, School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia.

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http://dx.doi.org/10.3389/fphar.2019.00405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491841PMC
April 2019

Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice.

Acta Pharmacol Sin 2019 Mar 4. Epub 2019 Mar 4.

State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, 210023, China.

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http://dx.doi.org/10.1038/s41401-018-0208-2DOI Listing
March 2019

DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats.

Int J Mol Med 2019 Feb 18;43(2):749-760. Epub 2018 Dec 18.

School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan 650500, P.R. China.

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http://dx.doi.org/10.3892/ijmm.2018.4034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317674PMC
February 2019

Matrine reduces cigarette smoke-induced airway neutrophilic inflammation by enhancing neutrophil apoptosis.

Clin Sci (Lond) 2019 Feb 18;133(4):551-564. Epub 2019 Feb 18.

School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia

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http://dx.doi.org/10.1042/CS20180912DOI Listing
February 2019

Repurposing matrine for the treatment of hepatosteatosis and associated disorders in glucose homeostasis in mice.

Acta Pharmacol Sin 2018 Nov 6;39(11):1753-1759. Epub 2018 Jul 6.

School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia.

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http://www.nature.com/articles/s41401-018-0016-8
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http://dx.doi.org/10.1038/s41401-018-0016-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289344PMC
November 2018

Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice.

J Endocrinol 2018 Nov 1. Epub 2018 Nov 1.

X Shen, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, China.

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http://dx.doi.org/10.1530/JOE-18-0432DOI Listing
November 2018

Isosteviol ameliorates diabetic cardiomyopathy in rats by inhibiting ERK and NF-κB signaling pathways.

J Endocrinol 2018 Jul 2;238(1):47-60. Epub 2018 May 2.

Institute of Biomedical & Pharmaceutical ScienceGuangdong University of Technology, Guangzhou, China

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http://dx.doi.org/10.1530/JOE-17-0681DOI Listing
July 2018

Design, synthesis and biological evaluation of novel bouchardatine analogs as potential inhibitors of adipogenesis/lipogenesis in 3T3-L1 adipocytes.

Eur J Med Chem 2018 Mar 31;147:90-101. Epub 2018 Jan 31.

Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangzhou, 510006, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.01.089DOI Listing
March 2018

Angiotensin II Causes β-Cell Dysfunction Through an ER Stress-Induced Proinflammatory Response.

Endocrinology 2017 10;158(10):3162-3173

School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology University, Bundoora, Victoria 3083, Australia.

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http://dx.doi.org/10.1210/en.2016-1879DOI Listing
October 2017

Natural alkaloid bouchardatine ameliorates metabolic disorders in high-fat diet-fed mice by stimulating the sirtuin 1/liver kinase B-1/AMPK axis.

Br J Pharmacol 2017 08 21;174(15):2457-2470. Epub 2017 Jun 21.

Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.

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http://dx.doi.org/10.1111/bph.13855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513868PMC
August 2017

The superoxide dismutase mimetic tempol blunts diabetes-induced upregulation of NADPH oxidase and endoplasmic reticulum stress in a rat model of diabetic nephropathy.

Eur J Pharmacol 2017 Jul 22;807:12-20. Epub 2017 Apr 22.

Heart Failure Pharmacology, Baker Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia; Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria 3010, Australia; Department of Medicine, Monash University, Melbourne 3004, Clayton 3800, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2017.04.026DOI Listing
July 2017

Discovery of Novel Anti-Diabetic Drugs by Targeting Lipid Metabolism.

Curr Drug Targets 2015 ;16(12):1372-80

Molecular Pharmacology for Diabetes Group, Health Innovations Research Institute and School of Health Sciences, RMIT University, PO Box 71, Melbourne, Victoria 3083, Australia.

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August 2016

Endoplasmic reticulum stress up-regulates Nedd4-2 to induce autophagy.

FASEB J 2016 07 28;30(7):2549-56. Epub 2016 Mar 28.

Lipid Biology and Metabolic Disease Laboratory, School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology (RMIT) University, Melbourne, Victoria, Australia

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http://dx.doi.org/10.1096/fj.201500119DOI Listing
July 2016

Repurposing Drugs to Target the Diabetes Epidemic.

Trends Pharmacol Sci 2016 05 18;37(5):379-389. Epub 2016 Feb 18.

Molecular Pharmacology for Diabetes Group, School of Health and Biomedical Sciences, RMIT University, Melbourne, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2016.01.007DOI Listing
May 2016

Liver glycogen in type 2 diabetic mice is randomly branched as enlarged aggregates with blunted glucose release.

Glycoconj J 2016 Feb 31;33(1):41-51. Epub 2015 Oct 31.

School of Chemistry, University of Melbourne, Victoria, 3010, Australia.

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http://dx.doi.org/10.1007/s10719-015-9631-5DOI Listing
February 2016

Hepatic FoxO1 acetylation is involved in oleanolic acid-induced memory of glycemic control: novel findings from Study 2.

PLoS One 2014 15;9(9):e107231. Epub 2014 Sep 15.

Molecular Pharmacology for Diabetes, Health Innovations Research Institute and School of Health Sciences, Royal Melbourne Institute of Technology, Melbourne, Victoria, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107231PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164604PMC
January 2016

Dietary cholesterol induces hepatic inflammation and blunts mitochondrial function in the liver of high-fat-fed mice.

J Nutr Biochem 2016 Jan 26;27:96-103. Epub 2015 Sep 26.

Health Innovations Research Institute and School of Health Sciences, RMIT University, Melbourne, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2015.08.021DOI Listing
January 2016

Synthesis and Biological Evaluation of Novel Bouchardatine Derivatives as Potential Adipogenesis/Lipogenesis Inhibitors for Antiobesity Treatment.

J Med Chem 2015 Dec 1;58(23):9395-413. Epub 2015 Dec 1.

School of Pharmaceutical Sciences, Sun Yat-Sen University , Guangzhou 510006, People's Republic of China.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01566DOI Listing
December 2015

Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target.

Br J Pharmacol 2015 Sep 14;172(17):4303-18. Epub 2015 Jul 14.

Lipid Biology and Metabolic Disease, Health Innovations Research Institute and School of Health Sciences, RMIT University, Melbourne, Vic, Australia.

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http://dx.doi.org/10.1111/bph.13209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556469PMC
September 2015

Discovery of natural alkaloid bouchardatine as a novel inhibitor of adipogenesis/lipogenesis in 3T3-L1 adipocytes.

Bioorg Med Chem 2015 Aug 5;23(15):4719-27. Epub 2015 Jun 5.

School of Pharmaceutical Sciences, Yat-sen Sun University, Guangzhou 510006, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.05.057DOI Listing
August 2015

Fenofibrate insulates diacylglycerol in lipid droplet/ER and preserves insulin signaling transduction in the liver of high fat fed mice.

Biochim Biophys Acta 2015 Jul 21;1852(7):1511-9. Epub 2015 Apr 21.

Lipid Biology and Metabolic Disease Laboratory, Health Innovations Research Institute and School of Health Sciences, RMIT University, Melbourne, VIC, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09254439150011
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http://dx.doi.org/10.1016/j.bbadis.2015.04.005DOI Listing
July 2015

Restoration of autophagy alleviates hepatic ER stress and impaired insulin signalling transduction in high fructose-fed male mice.

Endocrinology 2015 Jan;156(1):169-81

Lipid Biology and Metabolic Disease Laboratory, Health Innovations Research Institute and School of Health Sciences, RMIT University, Melbourne, Victoria 3083, Australia.

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http://dx.doi.org/10.1210/en.2014-1454DOI Listing
January 2015

IRE1 impairs insulin signaling transduction of fructose-fed mice via JNK independent of excess lipid.

Biochim Biophys Acta 2015 Jan 29;1852(1):156-65. Epub 2014 Nov 29.

Molecular Pharmacology for Diabetes, Health Innovations Research Institute and School of Health Sciences, RMIT University, Melbourne, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.11.017DOI Listing
January 2015

Increasing leucine concentration stimulates mechanistic target of rapamycin signaling and cell growth in C2C12 skeletal muscle cells.

Nutr Res 2014 Nov 2;34(11):1000-7. Epub 2014 Oct 2.

School of Exercise and Nutrition Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.

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http://dx.doi.org/10.1016/j.nutres.2014.09.011DOI Listing
November 2014

Strategies for the discovery and development of anti-diabetic drugs from the natural products of traditional medicines.

J Pharm Pharm Sci 2013 ;16(2):207-16

Molecular Pharmacology for Diabetes Group, Health Innovation Research Institute and School of Health Sciences, RMIT University, Melbourne, VIC, Australia.

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March 2014

Activation of AMPK by bitter melon triterpenoids involves CaMKKβ.

PLoS One 2013 25;8(4):e62309. Epub 2013 Apr 25.

Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062309PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636144PMC
November 2013

Rutaecarpine analogues reduce lipid accumulation in adipocytes via inhibiting adipogenesis/lipogenesis with AMPK activation and UPR suppression.

ACS Chem Biol 2013 Oct 6;8(10):2301-11. Epub 2013 Sep 6.

School of Pharmaceutical Sciences and Institute of Medicinal Chemistry, Sun Yat-sen University , Guangzhou, China.

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http://dx.doi.org/10.1021/cb4003893DOI Listing
October 2013

TanshinoneIIA and cryptotanshinone protect against hypoxia-induced mitochondrial apoptosis in H9c2 cells.

PLoS One 2013 14;8(1):e51720. Epub 2013 Jan 14.

Traditional & Complementary Medicine Program, RMIT Health Innovations Research Institute, School of Health Sciences, RMIT University, Bundoora, Victoria, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051720PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544838PMC
July 2013

Activation of PPARα ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased endoplasmic reticulum stress.

Diabetes 2013 Jun 24;62(6):2095-105. Epub 2013 Jan 24.

Molecular Pharmacology for Diabetes Group, Health Innovations Research Institute and School of Health Sciences, RMIT University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.2337/db12-1397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661626PMC
June 2013

Oleanolic acid reduces hyperglycemia beyond treatment period with Akt/FoxO1-induced suppression of hepatic gluconeogenesis in type-2 diabetic mice.

PLoS One 2012 30;7(7):e42115. Epub 2012 Jul 30.

Molecular Pharmacology for Diabetes, Health Innovations Research Institute and School of Health Sciences, RMIT University, Melbourne, Victoria, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042115PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408432PMC
January 2013

Screening for the efficacy on lipid accumulation in 3T3-L1 cells is an effective tool for the identification of new anti-diabetic compounds.

Biochem Pharmacol 2012 Sep 20;84(6):830-7. Epub 2012 Jul 20.

Molecular Pharmacology for Diabetes Group, Health Innovations Research Institute and School of Health Sciences, RMIT University, Melbourne, Australia.

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http://dx.doi.org/10.1016/j.bcp.2012.07.003DOI Listing
September 2012

Arctigenin alleviates ER stress via activating AMPK.

Acta Pharmacol Sin 2012 Jul 18;33(7):941-52. Epub 2012 Jun 18.

Department of Tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China.

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http://dx.doi.org/10.1038/aps.2012.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011149PMC
July 2012

High-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice.

Diabetes 2010 Jan 15;59(1):256-65. Epub 2009 Oct 15.

National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db09-02
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http://dx.doi.org/10.2337/db09-0223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797930PMC
January 2010

AMP-activated protein kinase and muscle insulin resistance.

Front Biosci (Landmark Ed) 2009 Jan 1;14:4658-72. Epub 2009 Jan 1.

Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.

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January 2009

Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway.

Chem Biol 2008 Mar;15(3):263-73

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.

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http://dx.doi.org/10.1016/j.chembiol.2008.01.013DOI Listing
March 2008

Rosiglitazone treatment enhances acute AMP-activated protein kinase-mediated muscle and adipose tissue glucose uptake in high-fat-fed rats.

Diabetes 2006 Oct;55(10):2797-804

Diabetes and Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria St., Darlinghurst, NSW 2010, Australia.

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http://dx.doi.org/10.2337/db05-1315DOI Listing
October 2006

High-fat feeding reduces endothelium-dependent vasodilation in rats: differential mechanisms for saturated and unsaturated fatty acids?

Clin Exp Pharmacol Physiol 2006 Aug;33(8):708-13

Institute of Geriatric Medicine, General Hospital of Hebei Province, Shijiazhuang, Hebei, China.

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http://dx.doi.org/10.1111/j.1440-1681.2006.04422.xDOI Listing
August 2006

Both saturated and n-6 polyunsaturated fat diets reduce phosphorylation of insulin receptor substrate-1 and protein kinase B in muscle during the initial stages of in vivo insulin stimulation.

Endocrinology 2005 Dec 8;146(12):5596-603. Epub 2005 Sep 8.

Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1210/en.2005-0481DOI Listing
December 2005

Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms.

Diabetes 2004 Dec;53(12):3258-66

Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia.

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http://dx.doi.org/10.2337/diabetes.53.12.3258DOI Listing
December 2004

Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo.

Biochem Biophys Res Commun 2004 Feb;314(2):580-5

Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA.

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February 2004

Dual PPARalpha /gamma activation provides enhanced improvement of insulin sensitivity and glycemic control in ZDF rats.

Am J Physiol Endocrinol Metab 2003 Apr 10;284(4):E841-54. Epub 2002 Dec 10.

Research and Development, Novo Nordisk, DK-2880 Bagsvaerd, Denmark.

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http://dx.doi.org/10.1152/ajpendo.00348.2002DOI Listing
April 2003

PPARalpha /gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly.

Am J Physiol Endocrinol Metab 2003 Mar;284(3):E531-40

Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia.

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http://dx.doi.org/10.1152/ajpendo.00299.2002DOI Listing
March 2003

Prior thiazolidinedione treatment preserves insulin sensitivity in normal rats during acute fatty acid elevation: role of the liver.

Endocrinology 2002 Dec;143(12):4527-35

Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney, New South Wales 2010, Australia.

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http://dx.doi.org/10.1210/en.2002-220387DOI Listing
December 2002

Peroxisome proliferator activated receptors, fatty acids and muscle insulin resistance.

J R Soc Med 2002 ;95 Suppl 42:14-22

Garvan Institute of Medical Research, St Vincent's Hospital, Sydney, NSW 2010, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1308940PMC
September 2002