Publications by authors named "Ji Li"

1,796 Publications

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Nav1.8 in keratinocytes contributes to ROS-mediated inflammation in inflammatory skin diseases.

Redox Biol 2022 Aug 5;55:102427. Epub 2022 Aug 5.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China; Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. Electronic address:

Reactive oxygen species (ROS)-activated proinflammatory signals in keratinocytes play a crucial role in the immunoregulation of inflammatory skin diseases, including rosacea and psoriasis. Nav1.8 is a voltage-gated sodium ion channel, and its abnormal expression in the epidermal layer contributes to pain hypersensitivity in the skin. However, whether and how epidermal Nav1.8 is involved in skin immunoregulation remains unclear. This study was performed to identify the therapeutic role of Nav1.8 in inflammatory skin disorders. We found that Nav1.8 expression was significantly upregulated in the epidermis of rosacea and psoriasis skin lesions. Nav1.8 knockdown ameliorated skin inflammation in LL37-and imiquimod-induced inflammation mouse models. Transcriptome sequencing results indicated that Nav1.8 regulated the expression of pro-inflammatory mediators (IL1β and IL6) in keratinocytes, thereby contributing to immune infiltration in inflammatory skin disorders. In vitro, tumor necrosis factor alpha (TNFα), a cytokine that drives the development of various inflammatory skin disorders, increased Nav1.8 expression in keratinocytes. Knockdown of Nav1.8 eliminated excess ROS production, thereby attenuating the TNFα-induced production of inflammatory mediators; however, a Nav1.8 blocker did not have the same effect. Mechanistically, Nav1.8 reduced superoxide dismutase 2 (SOD2) activity by directly binding to SOD2 to prevent its deacetylation and mitochondrial localization, subsequently inducing ROS accumulation. Collectively, our study describes a central role for Nav1.8 in regulating pro-inflammatory responses in the skin and indicates a novel therapeutic strategy for rosacea and psoriasis.
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http://dx.doi.org/10.1016/j.redox.2022.102427DOI Listing
August 2022

Eosinophilic myocarditis complicated by right ventricle outflow tract thrombus.

QJM 2022 Aug 11. Epub 2022 Aug 11.

Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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http://dx.doi.org/10.1093/qjmed/hcac190DOI Listing
August 2022

Investigation on maintenance hemodialysis patients with mineral and bone disorder in Anhui province, China.

Int Urol Nephrol 2022 Aug 11. Epub 2022 Aug 11.

Department of Nephrology, The Second Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, China.

Background: Chronic kidney disease-mineral bone disorder (CKD-MBD) is a common comorbidity in patients with CKD. The study aims to describe the control rates of serum-corrected calcium (Ca), phosphate (P) and intact parathyroid hormone (iPTH) and its risk factors among maintenance hemodialysis (MHD) patients in Anhui Province of China.

Methods: The study was conducted in 27 hemodialysis centers of Anhui Province between January 1st 2020 and December 31th 2020. Chi-square test was used to compare the control rates of serum-corrected Ca, P and iPTH between the present study and DOPPS 4 or Anhui Province in 2014. Binary logistic regression analysis was used to explore the risk factors of the control rates of serum-corrected Ca, P and iPTH.

Results: A total of 3 025 MHD patients were recruited in this study, with a mean age of 54.8 (SD: 12.8) years, and 60.1% were males. According to the Chinese Diagnosis and Treatment Guidelines for CKD-MBD, the control rates of serum-corrected Ca, P and iPTH in the present study were 57.9%, 20.0% and 56.0%, respectively. Based on KDOQI guidelines (2003), the control rates of the above indicators were 43.1%, 35.3% and 22.3%, respectively. The control rates of serum-corrected Ca, P and iPTH in this study were lower than those of DOPPS 4 (P < 0.001). Compared to the results of Anhui Province in 2014, the control rate of corrected Ca was higher (P < 0.001) and the control rate of iPTH was lower (P = 0.005). Age, residential area, BMI, dialysis vintage, albumin and hemoglobin levels were factors of serum-corrected Ca, P and iPTH not within target range.

Conclusion: The control rates of serum-corrected Ca, P and iPTH in MHD patients in Anhui Province are relatively low. Monitoring and management should be strengthened to improve the prognosis of patients undergoing dialysis.
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http://dx.doi.org/10.1007/s11255-022-03328-9DOI Listing
August 2022

Comparison of Modified Broström Procedure with or without Suture Tape Augmentation Technique for the Chronic Lateral Ankle Instability.

Biomed Res Int 2022 27;2022:6172280. Epub 2022 Jul 27.

Senior Department of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital, No. 51, Fucheng Road, Haidian District, 100048 Beijing, China.

Purpose: To compare the clinical outcomes of the modified Broström repair (MBR) with or without suture tape augmentation (STA) for managing the chronic lateral ankle instability.

Methods: 72 patients with chronic lateral ankle instability treated at our hospital from January 2018 to July 2019 were included, with 37 patients receiving the MBR and 35 treated by the MBR with STA. The clinical efficacy of the two techniques was assessed in terms of VAS, AOFAS, and Karlsson scores and by physical examination in follow-ups.

Results: In all 72 patients, operations were successful, and the patients were followed up for 29.3 months on average (range, 24-43 months). There were no significant differences in preoperative pain, AOFAS, and Karlsson scores between the two groups. Compared with preoperative findings, all the functional scores were significantly improved in both groups 3 months after the operation and at the last follow-up. Three months after the operation, the STA group had significantly lower VAS and higher AOFAS scores than the isolated MBR group, suggesting that patients in the STA group suffered less pain and achieved better functional improvement. However, the VAS and functional scores at the last follow-up and the Karlsson score at 3 months postoperatively showed no intragroup difference in both groups.

Conclusion: MBR with or without STA could achieve good results for the treatment of chronic lateral ankle instability. Compared with the widely used MBR, combining with STA may be more effective in promoting rehabilitation in early term.
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http://dx.doi.org/10.1155/2022/6172280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348917PMC
August 2022

AcMYB1 Interacts With AcbHLH1 to Regulate Anthocyanin Biosynthesis in .

Front Plant Sci 2022 19;13:886313. Epub 2022 Jul 19.

Key Laboratory of South China Agricultural Plant Molecular Analysis and Gene Improvement, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China.

is one of the most popular foliage plants with abundant leaf phenotypes; therefore, anthocyanin coloration is a vital economic trait in . However, the molecular mechanisms underlying anthocyanin biosynthesis and its regulation remain unclear. In this study, and , transcription factor genes related to an R2R3-myeloblast (MYB) and a basic helix-loop-helix (bHLH), respectively, were isolated from "Red Valentine" and functionally characterized. AcMYB1 and AcbHLH1 were found to interact by Y2H and BiFC assay. was grouped into the AN2 subgroup and shared high homology with the known regulators of anthocyanin biosynthesis. Gene expression analysis showed that both and have similar expression patterns to anthocyanin structural genes and correlate with anthocyanin distribution in different tissues of . Light strongly promoted anthocyanin accumulation by upregulating the expression of anthocyanin-related genes in leaves. Ectopic expression of in tobacco remarkably increased anthocyanin accumulation in both vegetative and reproductive tissues at various developmental stages. These results provide insights into the regulation of anthocyanin biosynthesis in and are useful for breeding new cultivars with enhanced ornamental value.
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http://dx.doi.org/10.3389/fpls.2022.886313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344012PMC
July 2022

Distinct Denitrifying Phenotypes of Predominant Bacteria Modulate Nitrous Oxide Metabolism in Two Typical Cropland Soils.

Microb Ecol 2022 Aug 2. Epub 2022 Aug 2.

State Key Laboratory of Microbial Metabolism, and Joint International Research Laboratory of Metabolic & Developmental Sciences, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.

Denitrifying nitrous oxide (NO) emissions in agroecosystems result from variations in microbial composition and soil properties. However, the microbial mechanisms of differential NO emissions in agricultural soils are less understood. In this study, microcosm experiments using two main types of Chinese cropland soil were conducted with different supplements of nitrate and glucose to simulate the varying nitrogen and carbon conditions. The results show that NO accumulation in black soil (BF) was significantly higher than that in fluvo-aquic soil (FF) independent of nitrogen and carbon. The abundance of most denitrifying genes was significantly higher in FF, but the ratios of genes responsible for NO production (nirS and nirK) to the gene responsible for NO reduction (nosZ) did not significantly differ between the two soils. However, the soils showed obvious discrepancies in denitrifying bacterial communities, with a higher abundance of NO-generating bacteria in BF and a higher abundance of NO-reducing bacteria in FF. High accumulation of NO was verified by the bacterial isolates of Rhodanobacter predominated in BF due to a lack of NO reduction capacity. The dominance of Castellaniella and others in FF led to a rapid reduction in NO and thus less NO accumulation, as demonstrated when the corresponding isolate was inoculated into the studied soils. Therefore, the different phenotypes of NO metabolism of the distinct denitrifiers predominantly colonized the two soils, causing differing NO accumulation. This knowledge would help to develop a strategy for mitigating NO emissions in agricultural soils by regulating the phenotypes of NO metabolism.
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http://dx.doi.org/10.1007/s00248-022-02085-7DOI Listing
August 2022

Recurrence risk stratification and treatment strategies of patients with stage IVa-b hypopharyngeal squamous cell carcinoma.

Head Neck 2022 Sep;44(9):2030-2039

ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.

Background: Optimal treatment strategies for patients with stage IVa-b hypopharyngeal squamous cell carcinoma (HSCC) remain controversial. This study aimed to examine the high-risk factors of postoperative tumor recurrence after surgical resection of HSCC and devise individualized postoperative adjuvant treatment (POAT).

Methods: Overall, 218 patients with stage IVa-b HSCC who received surgery as initial treatment and with negative surgical margins were evaluated. Independent risk factors of recurrence were identified, and survival outcomes were compared according to recurrence risk and POAT use.

Results: POAT significantly improved recurrence-free survival (RFS) and overall survival (OS) only in the high-risk patients (p = 0.003 and 0.018, respectively). Compared with postoperative radiotherapy alone, postoperative chemoradiotherapy (pCRT) achieved significantly better RFS (p = 0.035) and OS (p = 0.048).

Conclusions: POATs are recommended for high-risk patients with stage Iva-b HSCC, with pCRT achieving superior outcomes. Regular re-examination after tumor resection is sufficient for low-risk patients.
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http://dx.doi.org/10.1002/hed.27074DOI Listing
September 2022

Detecting COVID-19 patients via MLES-Net deep learning models from X-Ray images.

BMC Med Imaging 2022 07 30;22(1):135. Epub 2022 Jul 30.

School of Computer and Communication Engineering, Changsha University of Science and Technology, Changsha, 410114, China.

Background: Corona Virus Disease 2019 (COVID-19) first appeared in December 2019, and spread rapidly around the world. COVID-19 is a pneumonia caused by novel coronavirus infection in 2019. COVID-19 is highly infectious and transmissible. By 7 May 2021, the total number of cumulative number of deaths is 3,259,033. In order to diagnose the infected person in time to prevent the spread of the virus, the diagnosis method for COVID-19 is extremely important. To solve the above problems, this paper introduces a Multi-Level Enhanced Sensation module (MLES), and proposes a new convolutional neural network model, MLES-Net, based on this module.

Methods: Attention has the ability to automatically focus on the key points in various information, and Attention can realize parallelism, which can replace some recurrent neural networks to a certain extent and improve the efficiency of the model. We used the correlation between global and local features to generate the attention mask. First, the feature map was divided into multiple groups, and the initial attention mask was obtained by the dot product of each feature group and the feature after the global pooling. Then the attention masks were normalized. At the same time, there were two scaling and translating parameters in each group so that the normalize operation could be restored. Then, the final attention mask was obtained through the sigmoid function, and the feature of each location in the original feature group was scaled. Meanwhile, we use different classifiers on the network models with different network layers.

Results: The network uses three classifiers, FC module (fully connected layer), GAP module (global average pooling layer) and GAPFC module (global average pooling layer and fully connected layer), to improve recognition efficiency. GAPFC as a classifier can obtain the best comprehensive effect by comparing the number of parameters, the amount of calculation and the detection accuracy. The experimental results show that the MLES-Net56-GAPFC achieves the best overall accuracy rate (95.27%) and the best recognition rate for COVID-19 category (100%).

Conclusions: MLES-Net56-GAPFC has good classification ability for the characteristics of high similarity between categories of COVID-19 X-Ray images and low intra-category variability. Considering the factors such as accuracy rate, number of network model parameters and calculation amount, we believe that the MLES-Net56-GAPFC network model has better practicability.
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http://dx.doi.org/10.1186/s12880-022-00861-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338656PMC
July 2022

Development of prediction model of low anterior resection syndrome for colorectal cancer patients after surgery based on machine-learning technique.

Cancer Med 2022 Jul 28. Epub 2022 Jul 28.

Nursing Department, West China Hospital, Sichuan University, Chengdu, China.

Background: Low anterior resection syndrome (LARS) is a common postoperative complication in patients with colorectal cancer, which seriously affects their postoperative quality of life. At present, the aetiology of LARS is still unclear, but some risk factors have been studied. Accurate prediction and early management of medical intervention are keys to improving the quality of life of such high-risk patients.

Objectives: Based on machine-learning methods, this study used the follow-up results of postoperative patients with colorectal cancer to develop prediction models for LARS and conducted a comparative analysis between the different models.

Methods: A total of 382 patients diagnosed with colorectal cancer and undergoing surgery at West China Hospital from April 2017 to December 2020 were retrospectively selected as the development cohort. Logistic regression, support vector machine, decision tree, random forest and artificial neural network algorithms were used to construct the prediction models of the obtained dataset. The models were internally validated using cross-validation. The area under the curve and Brier score measures were used to evaluate and compare the differentiation and calibration degrees of the models. The sensitivity, specificity, positive predictive value and negative predictive value of the different models were described for clinical use.

Results: A total of 342 patients were included, the incidence of LARS being 47.4% (162/342) during the six-month follow-up. After feature selection, the factors influencing the occurrence of LARS were found to be location, distance, diverting stoma, exsufflation and surgical type. The prediction models based on five machine-learning methods all showed acceptable performance.

Conclusions: The five models developed based on the machine-learning methods showed good prediction performance. However, considering the simplicity of clinical use of the model results, the logistic regression model is most recommended. The clinical applicability of these models will also need to be evaluated with external cohort data.
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http://dx.doi.org/10.1002/cam4.5041DOI Listing
July 2022

A Generative Adversarial Network Based a Rolling Bearing Data Generation Method Towards Fault Diagnosis.

Comput Intell Neurosci 2022 13;2022:7592258. Epub 2022 Jul 13.

Shenyang Aerospace University, Shenyang 110035, China.

As a new generative model, the generative adversarial network (GAN) has great potential in the accuracy and efficiency of generating pseudoreal data. Nowadays, bearing fault diagnosis based on machine learning usually needs sufficient data. If enough near-real data can be generated in the case of insufficient samples in the actual operating condition, the effect of fault diagnosis will be greatly improved. In this study, a new rolling bearing data generation method based on the generative adversarial network (GAN) is proposed, which can be trained adversarially and jointly via a learned embedding, and applied to solve fault diagnosis problems with insufficient data. By analyzing the time-domain characteristics of rolling bearing life cycle monitoring data in actual working conditions, the operation data are divided into three periods, and the construction and training of the generative adversarial network model are carried out. Data generated by adversarial are compared with the real data in the time domain and frequency domain, respectively, and the similarity between the generated data and the real data is verified.
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http://dx.doi.org/10.1155/2022/7592258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300344PMC
July 2022

Age-Independent Cardiac Protection by Pharmacological Activation of Beclin-1 During Endotoxemia and Its Association With Energy Metabolic Reprograming in Myocardium-A Targeted Metabolomics Study.

J Am Heart Assoc 2022 Jul 5;11(14):e025310. Epub 2022 Jul 5.

Department of Surgery, Burn & Shock Trauma Research Institute Loyola University Chicago Stritch School of Medicine Maywood IL.

Background We showed that Beclin-1-dependent autophagy protects the heart in young and adult mice that underwent endotoxemia. Herein, we compared the potential therapeutic effects of Beclin-1 activating peptide, TB-peptide, on endotoxemia-induced cardiac outcomes in young adult and aged mice. We further evaluated lipopolysaccharide (lipopolysaccharide)-induced and TB-peptide treatment-mediated alterations in myocardial metabolism. Methods and Results C57BL/6J mice that were 10 weeks and 24 months old were challenged by lipopolysaccharide using doses at which cardiac dysfunction occurred. Following the treatment of TB-peptide or control vehicle, heart contractility, circulating cytokines, and myocardial autophagy were evaluated. We detected that TB-peptide boosted autophagy, attenuated cytokines, and improved cardiac performance in both young and aged mice during endotoxemia. A targeted metabolomics assay was designed to detect a pool of 361 known metabolites, of which 156 were detected in at least 1 of the heart tissue samples. Lipopolysaccharide-induced impairments were found in glucose and amino acid metabolisms in mice of all ages, and TB-peptide ameliorated these alterations. However, lipid metabolites were upregulated in the young group but moderately downregulated in the aged by lipopolysaccharide, suggesting an age-dependent response. TB-peptide mitigated lipopolysaccharide-mediated trend of lipids in the young mice but had little effect on the aged. (Study registration: Project DOI: https://doi.org/10.21228/M8K11W). Conclusions Pharmacological activation of Beclin-1 by TB-peptide is cardiac protective in both young and aged population during endotoxemia, suggest a therapeutic potential for sepsis-induced cardiomyopathy. Metabolomics analysis suggests that an age-independent protection by TB-peptide is associated with reprograming of energy production via glucose and amino acid metabolisms.
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http://dx.doi.org/10.1161/JAHA.122.025310DOI Listing
July 2022

Swimming Impedes Intestinal Microbiota and Lipid Metabolites of Tumorigenesis in Colitis-Associated Cancer.

Front Oncol 2022 1;12:929092. Epub 2022 Jul 1.

Department of Endoscopy, Shanghai Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Accumulating data support that regular physical activity potentially inhibits chronic colitis, a risk factor for colitis-associated cancer (CAC). However, possible effects of physical activity on CAC and the underlying mechanisms remain poorly understood.

Methods: A pretreatment of swimming on azoxymethane/dextran sodium sulfate (AOM/DSS)-induced CAC mice was implemented to determine its protective effect. Inflammation and tumorigenesis were assessed using colorectums from C57BL/6 mice. In order to determine how swimming alters colonic lipid metabolism and gene expression, a comparative analysis was conducted. Meanwhile, alterations in intestinal microbiota and short-chain fatty acids (SCFAs) were detected and analyzed. Finally, an integration analysis of colonic lipid metabolism with gene expression and intestinal microbiota was performed respectively.

Result: Swimming pretreatment relieved bowel inflammation and minimized tumor formation. We demonstrated that prostaglandin E2 (PGE2)/PGE2 receptor 2 subtype (EP2) signaling as a potential regulatory target for swimming induces colonic lipid metabolites. Swimming-induced genera, Erysipelatoclostridium, Parabacteroides, Bacteroides, and Rikenellaceae_RC9_gut_group, induced intestinal SCFAs and affected the function of colonic lipid metabolites enriched in glycerophospholipid metabolism and choline metabolism in cancer.

Conclusion: According to our experiments, swimming pretreatment can protect mice from CAC by intervention in the possible link between colonic lipid metabolites and PGE2/EP2 signaling. Further, swimming-induced genera and probiotics promoted glycerophospholipid metabolism and choline metabolism in cancer, the major constituents of colonic lipid metabolites, and increased SCFAs, which were also important mechanisms for the anti-inflammatory and anti-tumorigenic effects of swimming.
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http://dx.doi.org/10.3389/fonc.2022.929092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285133PMC
July 2022

SHF Acts as a Novel Tumor Suppressor in Glioblastoma Multiforme by Disrupting STAT3 Dimerization.

Adv Sci (Weinh) 2022 Jul 17:e2200169. Epub 2022 Jul 17.

Department of Laboratory Medicine, Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu, 214023, China.

Sustained activation of signal transducer and activator of transcription 3 (STAT3) is a critical contributor in tumorigenesis and chemoresistance, thus making it an attractive cancer therapeutic target. Here, SH2 domain-containing adapter protein F (SHF) is identified as a tumor suppressor in glioblastoma Multiforme (GBM) and its negative regulation of STAT3 activity is characterized. Mechanically, SHF selectively binds and inhibits acetylated STAT3 dimerization without affecting STAT3 phosphorylation or acetylation. Additionally, by blocking STAT3-DNMT1 (DNA Methyltransferase 1) interaction, SHF relieves methylation of tumor suppressor genes. The SH2 domain is documented to be essential for SHF's actions on STAT3, and almost entirely replaces the functions of SHF on STAT3 independently. Moreover, the peptide C16 a peptide derived from the STAT3-binding sites of SHF inhibits STAT3 dimerization and STAT3/DNMT1 interaction, and achieves remarkable growth inhibition in GBM cells in vitro and in vivo. These findings strongly identify targeting of the SHF/STAT3 interaction as a promising strategy for developing an optimal STAT3 inhibitor and provide early evidence of the potential clinical efficacy of STAT3 inhibitors such as C16 in GBM.
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http://dx.doi.org/10.1002/advs.202200169DOI Listing
July 2022

Cassava () Slow Anion Channel () Gene Overexpression Enhances Nitrogen Assimilation, Growth, and Yield in Rice.

Front Plant Sci 2022 27;13:932947. Epub 2022 Jun 27.

College of Life Sciences, Neijiang Normal University, Neijiang, China.

Nitrogen is one of the most important nutrient elements required for plant growth and development, which is also immensely related to the efficient use of nitrogen by crop plants. Therefore, plants evolved sophisticated mechanisms and anion channels to extract inorganic nitrogen (nitrate) from the soil or nutrient solutions, assimilate, and recycle the organic nitrogen. Hence, developing crop plants with a greater capability of using nitrogen efficiently is the fundamental research objective for attaining better agricultural productivity and environmental sustainability. In this context, an in-depth investigation has been conducted into the cassava slow type anion channels () gene family, including genome-wide expression analysis, phylogenetic relationships with other related organisms, chromosome localization, and functional analysis. A potential and nitrogen-responsive gene of cassava () was identified and selected for overexpression (OE) analysis in rice, which increased the grain yield and root growth related performance. The morpho-physiological response of OE lines was better under low nitrogen (0.01 mm NHNO) conditions compared to the wild type (WT) and OE lines under normal nitrogen (0.5 mm NHNO) conditions. The relative expression of the gene was higher (about 80-fold) in the OE line than in the wild type. The accumulation and flux assay showed higher accumulation of and more expansion of root cells and grain dimension of OE lines compared to the wild type plants. The results of this experiment demonstrated that the gene may play a vital role in enhancing the efficient use of nitrogen in rice, which could be utilized for high-yielding crop production.
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http://dx.doi.org/10.3389/fpls.2022.932947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271942PMC
June 2022

Management and Analysis of Sports Health Level of the Elderly Based on Deep Learning.

Comput Intell Neurosci 2022 30;2022:6044320. Epub 2022 Jun 30.

College of Sports Science, Harbin Normal University, Harbin 150025, China.

With the accelerating rate of population aging in China, the health of the elderly has received more and more attention and has become one of the most important issues in the elderly care industry. Because of insufficient research on the personal health of the elderly, the value of medical examination data cannot be fully exploited, many physical indicators have a certain impact on overall health or heart health, and there are few studies on heart health assessment. This paper proposes a deep learning-based elderly management analysis method of human exercise health level, using the exercise health management model to evaluate the heart health level of the elderly. Firstly, the indicators to measure heart health are proposed through traditional expert knowledge and personal health index to analyze heart health. Through dynamic assessment, predict the heart health status at the next time point, analyze possible heart diseases, and provide corresponding methods for the health of the elderly, which helps improve the physical health of the elderly. Quality of life provides assistance to meet the needs of improving the health of older adults.
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http://dx.doi.org/10.1155/2022/6044320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262495PMC
July 2022

UGT1A1 and UGT1A9 Are Responsible for Phase II Metabolism of Tectorigenin and Irigenin In Vitro.

Molecules 2022 Jun 26;27(13). Epub 2022 Jun 26.

Department of Pharmacy, Eye and ENT Hospital, Fudan University, Shanghai 200031, China.

Tectorigenin and irigenin are biologically active isoflavones of (L.) DC. Previous studies indicated that both compounds could be metabolized in vivo; however, the kinetic parameters of enzymes involved in the metabolization of tectorigenin and irigenin have not been identified. The aim of this study was to investigate UGTs involved in the glucuronidation of tectorigenin and irigenin and determine enzyme kinetic parameters using pooled human liver microsomes (HLMs) and recombinant UGTs. Glucuronides of tectorigenin and irigenin were identified using high-performance liquid chromatography (HPLC) coupled with mass spectrometry and quantified by HPLC using a response factor method. The results showed that tectorigenin and irigenin were modified by glucuronidation in HLMs. One metabolite of tectorigenin (M) and two metabolites of irigenin (M1 and M2) were detected. Chemical inhibition and recombinant enzyme experiments revealed that several enzymes could catalyze tectorigenin and irigenin glucuronidation. Among them, UGT1A1 and UGT1A9 were the primary enzymes for both tectorigenin and irigenin; however, the former mostly produced irigenin glucuronide M1, while the latter mostly produced irigenin glucuronide M2. These findings suggest that UGT1A1 and UGT1A9 were the primary isoforms metabolizing tectorigenin and irigenin in HLMs, which could be involved in drug-drug interactions and, therefore, should be monitored in clinical practice.
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http://dx.doi.org/10.3390/molecules27134104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268515PMC
June 2022

The Interaction of and in Neurogenesis and Its Implication in Neurodegenerative Diseases.

Cells 2022 Jun 28;11(13). Epub 2022 Jun 28.

Department of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

Neurogenesis occurs in the brain during embryonic development and throughout adulthood. Neurogenesis occurs in the hippocampus and under normal conditions and persists in two regions of the brain-the subgranular zone (SGZ) in the dentate gyrus of the hippocampus and the subventricular zone (SVZ) of the lateral ventricles. As the critical role in neurogenesis, the neural stem cells have the capacity to differentiate into various cells and to self-renew. This process is controlled through different methods. The mammalian target of rapamycin () controls cellular growth, cell proliferation, apoptosis, and autophagy. The transcription factor (nuclear factor erythroid 2-related factor 2) is a major regulator of metabolism, protein quality control, and antioxidative defense, and is linked to neurogenesis. However, dysregulation in neurogenesis, , and activity have all been associated with neurodegenerative diseases such as Alzheimer's, Huntington's, and Parkinson's. Understanding the role of these complexes in both neurogenesis and neurodegenerative disease could be necessary to develop future therapies. Here, we review both and complexes, their crosstalk and role in neurogenesis, and their implication in neurodegenerative diseases.
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http://dx.doi.org/10.3390/cells11132048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265429PMC
June 2022

CHST15 gene germline mutation is associated with the development of familial myeloproliferative neoplasms and higher transformation risk.

Cell Death Dis 2022 Jul 7;13(7):586. Epub 2022 Jul 7.

Department of Hematology, Institute of Molecular Hematology, The Second XiangYa Hospital, Central South University, Changsha, Hunan, China.

Herein, we describe the clinical and hematological features of three genetically related families predisposed to myeloproliferative neoplasms (MPNs). Using whole-exome sequencing, we identified a c.1367delG mutation(p.Arg456fs) in CHST15 (NM_001270764), a gene encoding a type II transmembraneglycoproteinthat acts as a sulfotransferase and participates in the biosynthesis of chondroitin sulfate E, in germline and somatic cells in familial MPN. CHST15defects caused an increased JAK2V617F allele burden and upregulated p-Stat3 activity,leading to an increase in the proliferative and prodifferentiation potential of transgenic HEL cells. We demonstrated that mutant CHST15 is able to coimmmunoprecipitate the JAK2 protein,suggesting the presence of a CHST15-JAK2-Stat3 signaling axis in familial MPN. Gene expression profiling showed that the FREM1, IFI27 and C4B_2 genes are overexpressed in familial MPN, suggesting the activation of an "inflammatory response-extracellular matrix-immune regulation" signaling network in the CHST15 mutation background.We thus concluded that CHST15 is a novel gene that predisposes to familial MPN and increases the probability of disease development or transformation.
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http://dx.doi.org/10.1038/s41419-022-05035-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263130PMC
July 2022

Exogenous GA promotes flowering in (Orchidaceae) through bolting and lateral flower development regulation.

Hortic Res 2022 22;9:uhac091. Epub 2022 Apr 22.

Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China.

orchids have a high ornamental value, and their flower abundance and timing are both key horticultural traits regulated by phytohormones. All one-flowered have additional lateral buds in the apical bract that fail to develop. In this study, an exogenous gibberellin (GA) application promoted flowering of by inducing its early bolting instead of the floral transition of dominant flowers. Applying GA effectively promoted lateral flower differentiation, resulting in a two-flowered inflorescence. GA-promoted lateral flower formation involved GA interacting with indole-3-acetic acid (IAA) and cytokinins (CTKs), given the decreased CTK content and downregulated expression of CTK synthesis genes, the increased IAA content and downregulated expression of IAA degradation, and the upregulated expression of transport genes. Further, GA acted via , , and expressed in stage 5 to promote bolting, and via expression of , , and to promote flowering. This study provides insight into mechanisms regulating flower development of .
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http://dx.doi.org/10.1093/hr/uhac091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249578PMC
April 2022

Low frequency vibrating magnetic field-triggered magnetic microspheres with a nanoflagellum-like surface for cancer therapy.

J Nanobiotechnology 2022 Jul 6;20(1):316. Epub 2022 Jul 6.

Research Center for Translational Medicine at Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, People's Republic of China.

Background: The magneto-mechanical force killing cancer cells is an interesting and important strategy for cancer therapy.

Results: Novel magnetic microspheres composed of a FeO nanocore, a bovine serum albumin (BSA) matrix, and a rod-like SiO nanoshell, which had flagellum-like surface for force-mediated cancer therapy were developed. One such magnetic microsphere (FeO/BSA/rSiO) at a cancer cell (not leave the cell surface) under a low frequency vibrating magnetic field (VMF) could generate 6.17 pN force. Interestingly, this force could induce cancer cell to generate reactive oxygen species (ROS). The force and force-induced ROS could kill cancer cells. The cell killing efficiency of FeO/BSA/rSiO exposed to a VMF was enhanced with increasing silica nanorod length, and the microspheres with straight nanorods exhibited stronger cell killing ability than those with curled nanorods. FeO/BSA/rSiO triggered by a VMF could efficiently inhibit mouse tumor growth, while these microspheres without a VMF had no significant effect on the cell cycle distribution, cell viability, tumor growth, and mouse health.

Conclusions: These microspheres with unique morphological characteristics under VMF have great potential that can provide a new platform for treating solid tumors at superficial positions whether with hypoxia regions or multidrug resistance.
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http://dx.doi.org/10.1186/s12951-022-01521-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258173PMC
July 2022

High-Dose Dual Therapy Versus Bismuth-Containing Quadruple Therapy for the Treatment of Helicobacter pylori Infection: A Systematic Review with Meta-Analysis.

Turk J Gastroenterol 2022 06;33(6):454-462

Fujian Medical University The Third Clinical Medical College, Fuzhou, Fujian, China; Department of Gastroenterology, The First Affiliated Hospital of Xiamen University Faculty of Medicine, Xiamen, China.

Background: This study aimed to evaluate the efficacy and safety of high-dose dual therapy for Helicobacter pylori (H. pylori) eradication compared to bismuth-containing quadruple therapy.

Methods: The electronic database of PubMed, Embase, and Cochrane Library were searched from inception to March 18, 2021. Randomized, controlled trials that evaluated high-dose dual therapy versus bismuth-containing quadruple therapy for H. pylori infection were included.

Results: We included 6 studies containing 1677 patients with H. pylori infection. This meta-analysis demonstrated that high-dose dual therapy achieved similar eradication rate compared with bismuth-containing quadruple therapy (intention-to-treat: 84.6% vs 83.7%, relative risk (RR) = 1.01, 95% CI: 0.97-1.06, P = .49; per-protocol = 88.4% vs 89.0%, RR = 1.00, 95% CI: 0.97-1.04, P = .99). However, highdose dual therapy showed fewer side effects (13.1% vs 32.0%, RR = 0.51, 95% CI: 0.34-0.78, P = .002) and better compliance (96.1% vs 93.3%, RR = 1.03, 95% CI: 1.00-1.05, P = .03) compared to bismuth-containing quadruple therapy.

Conclusion: This meta-analysis demonstrated that high-dose dual therapy is equally effective with bismuth-containing quadruple therapy in eradicating H. pylori, with fewer side effects and better compliance.
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http://dx.doi.org/10.5152/tjg.2022.21579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317580PMC
June 2022

Genome-Wide Identification of 6-Methyladenosine Associated SNPs as Potential Functional Variants for Type 1 Diabetes.

Front Endocrinol (Lausanne) 2022 16;13:913345. Epub 2022 Jun 16.

Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Objectives: N6-methyladenosine (m6A) is essential in the regulation of the immune system, but the role that its single nucleotide polymorphisms (SNPs) play in the pathogenesis of type 1 diabetes (T1D) remains unknown. This study demonstrated the association between genetic variants in m6A regulators and T1D risk based on a case-control study in a Chinese population.

Methods: The tagging SNPs in m6A regulators were genotyped in 1005 autoantibody-positive patients with T1D and 1257 controls using the Illumina Human OmniZhongHua-8 platform. Islet-specific autoantibodies were examined by radioimmunoprecipitation in all the patients. The mixed-meal glucose tolerance test was performed on 355 newly diagnosed patients to evaluate their residual islet function. The functional annotations for the identified SNPs were performed in silico. Using 102 samples from a whole-genome expression microarray, key signaling pathways associated with m6A regulators in T1D were comprehendingly evaluated.

Results: Under the additive model, we observed three tag SNPs in the noncoding region of the PRRC2A (rs2260051, rs3130623) and YTHDC2 (rs1862315) gene are associated with T1D risk. Although no association was found between these SNPs and islet function, patients carrying risk variants had a higher positive rate for ZnT8A, GADA, and IA-2A. Further analyses showed that rs2260051[T] was associated with increased expression of PRRC2A mRNA ( = 7.0E-13), and PRRC2A mRNA was significantly higher in peripheral blood mononuclear cell samples from patients with T1D compared to normal samples ( = 0.022). Enrichment analyses indicated that increased PRRC2A expression engages in the most significant hallmarks of cytokine-cytokine receptor interaction, cell adhesion and chemotaxis, and neurotransmitter regulation pathways. The potential role of increased PRRC2A in disrupting immune homeostasis is through the PI3K/AKT pathway and neuro-immune interactions.

Conclusion: This study found intronic variants in PRRC2A and YTHDC2 associated with T1D risk in a Chinese Han population. PRRC2A rs2260051[T] may be implicated in unbalanced immune homeostasis by affecting the expression of PRRC2A mRNA. These findings enriched our understanding of m6A regulators and their intronic SNPs that underlie the pathogenesis of T1D.
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http://dx.doi.org/10.3389/fendo.2022.913345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243540PMC
June 2022

The complete chloroplast genome of Craib 1914, an economically valuable oil crop.

Mitochondrial DNA B Resour 2022 23;7(6):1099-1100. Epub 2022 Jun 23.

Research Institute of Subtropical Forestry, Chinese Academy of Forestry, Hangzhou, China.

Craib 1914 is an industrially valuable oil crop from southern China for which little genetic information is available. Here, we found that its complete chloroplast genome is a circular sequence (156,905 bp) with a large single-copy region (LSC) of 67,724 bp, a small single copy region (SSC) of 18,400 bp, and two inverted repeats (IRs). In total, 130 genes were identified, including 86 protein-coding genes, 36 transfer RNAs, and 8 rRNA genes. Phylogenetic analysis showed that is close to . These results provide valuable information for accelerating research on the evolution of camellias.
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http://dx.doi.org/10.1080/23802359.2022.2087547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246039PMC
June 2022

Future climate change enhances the complexity of plastisphere microbial co-occurrence networks, but does not significantly affect the community assembly.

Sci Total Environ 2022 Jun 28;844:157016. Epub 2022 Jun 28.

UFZ-Helmholtz Centre for Environmental Research, Department of Soil Ecology, Theodor-Lieser-Str. 4, 06120 Halle (Saale), Germany. Electronic address:

Biobased and biodegradable plastics have been intensively used in agriculture as mulching films. They provide a distinctive habitat for soil microbes, yet much less is known about the community assembly and interactions of plastisphere microbiota in soils under future climate change. For the first time, we explored the relative importance of ecological processes and the co-occurrence networks of plastic-associated microbes under ambient and future climates. The drift primarily dominated the community assembly of bacteria and fungi after 180D and 328D incubation in both climate regimes. The neutral community model prediction indicated that the migration rate of the plastisphere community in the later decay phase was lower than that in the early decay phase, contributing to the generation of the specific niches. Furthermore, future climate promoted the complexity and modularity of plastic-associated microbial networks: more competition and cooperation were observed in bacteria (or inter-kingdom) and fungi under future climate conditions, respectively. Overall, our findings strengthened the understanding of ecological processes and interplay of plastisphere microbiota during plastic biodegradation in soils under ambient and future climate regimes.
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http://dx.doi.org/10.1016/j.scitotenv.2022.157016DOI Listing
June 2022

Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state.

Dev Cell 2022 Jul 30;57(14):1758-1775.e7. Epub 2022 Jun 30.

Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA; NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, CA 92697, USA. Electronic address:

Hair follicle stem cells are regulated by dermal papilla fibroblasts, their principal signaling niche. Overactivation of Hedgehog signaling in the niche dramatically accelerates hair growth and induces follicle multiplication in mice. On single-cell RNA sequencing, dermal papilla fibroblasts increase heterogeneity to include new Wnt5a states. Transcriptionally, mutant fibroblasts activate regulatory networks for Gli1, Alx3, Ebf1, Hoxc8, Sox18, and Zfp239. These networks jointly upregulate secreted factors for multiple hair morphogenesis and hair-growth-related pathways. Among these is non-conventional TGF-β ligand Scube3. We show that in normal mouse skin, Scube3 is expressed only in dermal papillae of growing, but not in resting follicles. SCUBE3 protein microinjection is sufficient to induce new hair growth, and pharmacological TGF-β inhibition rescues mutant hair hyper-activation phenotype. Moreover, dermal-papilla-enriched expression of SCUBE3 and its growth-activating effect are partially conserved in human scalp hair follicles. Thus, Hedgehog regulates mesenchymal niche function in the hair follicle via SCUBE3/TGF-β mechanism.
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http://dx.doi.org/10.1016/j.devcel.2022.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344965PMC
July 2022

Regulation and dysregulation of hair regeneration: aiming for clinical application.

Cell Regen 2022 Jul 1;11(1):22. Epub 2022 Jul 1.

Department of Pathology, University of Southern California, Los Angeles, CA, USA.

Hair growth and regeneration represents a remarkable example of stem cell function. Recent progress emphasizes the micro- and macro- environment that controls the regeneration process. There is a shift from a stem cell-centered view toward the various layers of regulatory mechanisms that control hair regeneration, which include local growth factors, immune and neuroendocrine signals, and dietary and environmental factors. This is better suited for clinical application in multiple forms of hair disorders: in male pattern hair loss, the stem cells are largely preserved, but androgen signaling diminishes hair growth; in alopecia areata, an immune attack is targeted toward the growing hair follicle without abrogating its regeneration capability. Genome-wide association studies further revealed the genetic bases of these disorders, although the precise pathological mechanisms of the identified loci remain largely unknown. By analyzing the dysregulation of hair regeneration under pathological conditions, we can better address the complex interactions among stem cells, the differentiated progeny, and mesenchymal components, and highlight the critical role of macroenvironment adjustment that is essential for hair growth and regeneration. The poly-genetic origin of these disorders makes the study of hair regeneration an interesting and challenging field.
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http://dx.doi.org/10.1186/s13619-022-00122-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247129PMC
July 2022

The Role of Diabetes Mellitus in the Malignant Pancreatic Cyst Neoplasm Diagnosis and Prognosis.

Cancer Manag Res 2022 22;14:2091-2104. Epub 2022 Jun 22.

Department of Pancreatic Surgery, Pancreatic Disease Institute, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.

Purpose: Pancreatic cyst neoplasm (PCN) is a precursor of pancreatic cancer. Previous studies reported PCN was often concurrent with diabetes. We aim to examine the association between diabetes with PCN malignancy and to detect the potential role of diabetes in PCN management and treatment.

Patients And Methods: A total of 224 patients who were diagnosed with the three major types of PCN (IPMN, MCN, and SCN) and underwent surgical resection were selected. Patients were divided into three groups (normal group, new-onset diabetes group (NODM) (<4years), and long-standing diabetes group (LSDM) (>4years)) according to diabetic history and diagnostic time interval. Diabetes, fast blood glucose level, HbA1c, and insulin resistance level were measured. Malignant PCN (mPCN) radiological features (worrisome features and high-risk stigmata) were analyzed. Pathological features (PCN type, dysplasia grade, tumor stage, and tumor volume) and immunohistology of Ki67 and SMAD4 were performed. Diagnostic efficacy of each variable was determined by the ROC curve. mPCN diagnosis was the main outcome in diagnostic prediction and overall survival as the glucose controlling outcome variables.

Results: Diabetes groups (NODM and LSDM) showed difference with the normal group in age, weight loss, malignancy, CA19-9 value, CEA value, Ki-67 value, tumor volume, pathological grade, and a lowered pancreatic fistula risk. NODM was related to insulin resistance, weight loss, and SMAD4 mutation. NODM (87.3%) and high insulin resistance rate (93.6%) significantly increased the sensitivity of radiological evidence-based mPCN diagnosis. Moreover, long-standing diabetes and elevated HbA1c led to reduced survival in mPCN patients than the normal PCN group. Anti-diabetic drugs showed limited influence on PCN malignancy and tumor volume.

Conclusion: NODM in PCN patients was associated with malignancy, insulin resistance, weight loss, and SMAD4 mutation. Prediabetic status and NODM diagnosis enhanced the diagnostic accuracy of radiological standards (worrisome features and high-risk stigmata). Stable glucose surveillance is necessary for mPCN patients' survival.
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http://dx.doi.org/10.2147/CMAR.S355365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234315PMC
June 2022

Analysis of pilots' EEG map in take-off and landing tasks.

Biomed Tech (Berl) 2022 Jun 28. Epub 2022 Jun 28.

School of Mechatronics Engineering, Shenyang Aerospace University, Shenyang, P. R. China.

The take-off and landing phases are considered the critical stages of aircraft flight. To ensure flight efficiency and safety in the critical stages, this research proposes a method for analyzing and monitoring pilot flight status by β-wave. The focus of the study is β potential changes on the EEG map. First, the proportion of β-wave in the electroencephalogram (EEG) of pilots during take-off and landing increases significantly. Second, the EEG map accurately and intuitively reflects the spatial distribution of potential changes in brain regions. Finally, correlation and machine learning are used for further research of β-wave. The conclusions show that the significant changes in the β-wave caused by take-off and landing can be seen in the EEG map to identify and adjust the pilot's state. Therefore, this research provides more accurate and effective reference information (like the EEG map, correlation and machine learning) for efficient and safe flight training in the critical stages.
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http://dx.doi.org/10.1515/bmt-2021-0418DOI Listing
June 2022

Accelerate sulfamethoxazole degradation and detoxification by persulfate mediated with Fe&dithionite: Experiments and DFT calculation.

J Hazard Mater 2022 08 1;436:129254. Epub 2022 Jun 1.

School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen 518055, China.

Advanced oxidation process (AOPs) is one of the most effective technologies for organic pollutants removal. In this study, diverse reactive species generation and enhanced sulfamethoxazole (SMX) degradation were investigated based on persulfate (PDS) activated by Fe&dithionite (DTN). When involving Fe&dithionite in PDS, SMX degradation efficiency reached 84 % within 30 min following a pseudo-first-order kinetic, which was higher than those in Fe/PDS (50.4 %) and Fe/O/DTN (41.3 %). SO and OH were identified as dominant reactive species with a crucial role of FeSO based on quenching experiment and electron spin resonance (ESR). The contributions of SO, OH, and other species to SMX degradation were 60.1 %, 33.9 %, and 6 %, respectively. In Fe/DTN/PDS system, SMX was effectively degraded under nearly neutral pH (5.0-9.0), with activation energy of 96.04 kJ·mol. The experiments and density functional theory (DFT) calculation demonstrated that three functional groups (benzenesulfonamido, benzene ring, and oxazole ring) were attacked for SMX degradation. Moreover, acute toxicity to Vibrio fischeri has enhanced in the earlier degradation process due to the intermediates and weaken with the continuous reaction. This work not only provides a high-activity SO-AOP for refractory pollutant treatment with possible dual radical generation resources, but elucidated diverse reactive species formation with Fe&dithionite.
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http://dx.doi.org/10.1016/j.jhazmat.2022.129254DOI Listing
August 2022
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