Publications by authors named "Ji Hong Lim"

56Publications

Molecular Targeting of VEGF with a Suramin Fragment-DOCA Conjugate by Mimicking the Action of Low Molecular Weight Heparins.

Biomolecules 2020 Dec 31;11(1). Epub 2020 Dec 31.

Department of Biotechnology, College of Biomedical & Health Science, Konkuk University, Chungju 27478, Korea.

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December 2020

Cinobufagin Suppresses Melanoma Cell Growth by Inhibiting LEF1.

Int J Mol Sci 2020 Sep 13;21(18). Epub 2020 Sep 13.

Department of Biomedical Chemistry, College of Biomedical & Health Science, Konkuk University, Chungju 27478, Korea.

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September 2020

Ursolic Acid Suppresses Cholesterol Biosynthesis and Exerts Anti-Cancer Effects in Hepatocellular Carcinoma Cells.

Int J Mol Sci 2019 Sep 26;20(19). Epub 2019 Sep 26.

Department of Applied Life Science, Graduate School of Konkuk University, College of Biomedical & Health Science, Konkuk University, Chungju 27478, Korea.

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September 2019

HSF1 Regulates Mevalonate and Cholesterol Biosynthesis Pathways.

Cancers (Basel) 2019 Sep 13;11(9). Epub 2019 Sep 13.

Department of Applied Life Sciences, Graduate School of Konkuk University, College of Biomedical & Health Science, Konkuk University, Chungju 27478, Chungbuk, Korea.

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September 2019

IDH1 Causes Resistance to HDAC Inhibitors by Increasing NANOG in Glioblastoma Cells.

Int J Mol Sci 2019 May 31;20(11). Epub 2019 May 31.

Department of Applied Life Science, Graduate School of Konkuk University, College of Biomedical & Health Science, Konkuk University, Chungju 27478, Chungbuk, Korea.

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May 2019

Thymoquinone Selectively Kills Hypoxic Renal Cancer Cells by Suppressing HIF-1α-Mediated Glycolysis.

Int J Mol Sci 2019 Mar 3;20(5). Epub 2019 Mar 3.

Department of Biomedical Chemistry, College of Biomedical & Health Science, Konkuk University, Chungju 27478, Korea.

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March 2019

Acquired diffuse slate-grey facial dyspigmentation due to henna: an unrecognized cause of pigment contact dermatitis in Korean patients.

Eur J Dermatol 2018 Oct;28(5):644-648

Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

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October 2018

Zerumbone, a Tropical Ginger Sesquiterpene of Roscoe, Attenuates α-MSH-Induced Melanogenesis in B16F10 Cells.

Int J Mol Sci 2018 Oct 13;19(10). Epub 2018 Oct 13.

Department of Biomedical Chemistry, College of Biomedical & Health Science, Konkuk University, Chungju 27478, Chungbuk, Korea.

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October 2018

Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib through Suppression of Cholesterol Metabolism.

Int J Mol Sci 2018 Oct 12;19(10). Epub 2018 Oct 12.

Department of Biomedical Chemistry, College of Biomedical & Health Science, Konkuk University, Chungju 27478, Chungbuk, Korea.

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October 2018

A Case of Stevens-Johnson Syndrome Probably Induced by Herbal Medicine.

Ann Dermatol 2018 Aug 27;30(4):481-483. Epub 2018 Jun 27.

Department of Dermatology, The Catholic University of Korea, Incheon St. Mary's Hospital, Seoul, Korea.

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August 2018

The Effects of Aronia melanocarpa 'Viking' Extracts in Attenuating RANKL-Induced Osteoclastic Differentiation by Inhibiting ROS Generation and c-FOS/NFATc1 Signaling.

Molecules 2018 Mar 8;23(3). Epub 2018 Mar 8.

Department of Applied Life Science, College of Biomedical & Health Science, Konkuk University, Chungju-si, Chungcheongbuk-do 27478, Korea.

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March 2018

Fascaplysin Sensitizes Anti-Cancer Effects of Drugs Targeting AKT and AMPK.

Molecules 2017 Dec 24;23(1). Epub 2017 Dec 24.

Department of Biomedical Chemistry, College of Biomedical & Health Science, Konkuk University, Chungju 27478, Chungbuk, Korea.

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December 2017

Caspase-4 is essential for saikosaponin a-induced apoptosis acting upstream of caspase-2 and γ-H2AX in colon cancer cells.

Oncotarget 2017 Nov 1;8(59):100433-100448. Epub 2017 Nov 1.

Severance Integrative Research Institute for Cerebral & Cardiovascular Diseases (SIRIC), Yonsei University College of Medicine, Seodaemun-gu, Seoul 03722, Republic of Korea.

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November 2017

Prevalence and clinicopathologic characteristics of multiple myeloma with cutaneous involvement: A case series from Korea.

J Am Acad Dermatol 2018 03 6;78(3):471-478.e4. Epub 2017 Nov 6.

Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

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March 2018

Fascaplysin Exerts Anti-Cancer Effects through the Downregulation of Survivin and HIF-1α and Inhibition of VEGFR2 and TRKA.

Int J Mol Sci 2017 Sep 29;18(10). Epub 2017 Sep 29.

Department of Biomedical Chemistry, College of Biomedical & Health Science, Konkuk University, Chungju 27478, Chungbuk, Korea.

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September 2017

Role of Protein Kinases and Their Inhibitors in Radiation Response of Tumor Cells.

Curr Pharm Des 2017 11;23(29):4259-4280

New Drug Development Center, DGMIF, 80 Chumbok-ro, Dong-gu, Daegu 41061, Korea.

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November 2017

Inhibition of NAT10 Suppresses Melanogenesis and Melanoma Growth by Attenuating Microphthalmia-Associated Transcription Factor (MITF) Expression.

Int J Mol Sci 2017 Sep 7;18(9). Epub 2017 Sep 7.

Department of Biomedical Chemistry, College of Biomedical & Health Science, Konkuk University, Chungju 27478, Chungbuk, Korea.

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September 2017

Analysis of apoptosis-associated molecules Erythroid differentiation regulator 1, bcl-2 and p53 in actinic keratosis after treatment with ingenol mebutate.

Exp Dermatol 2017 11 3;26(11):1012-1017. Epub 2017 Jul 3.

Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

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November 2017

Vanillin Suppresses Cell Motility by Inhibiting STAT3-Mediated HIF-1α mRNA Expression in Malignant Melanoma Cells.

Int J Mol Sci 2017 Mar 1;18(3). Epub 2017 Mar 1.

Department of Biomedical Chemistry, College of Biomedical & Health Science, Konkuk University, Chungju 380-701, Korea.

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March 2017

Plumbagin Suppresses α-MSH-Induced Melanogenesis in B16F10 Mouse Melanoma Cells by Inhibiting Tyrosinase Activity.

Int J Mol Sci 2017 Feb 3;18(2). Epub 2017 Feb 3.

Department of Biomedical Chemistry, College of Biomedical and Health Science, Konkuk University, Chungju 380-701, Korea.

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February 2017

Rosacea: Molecular Mechanisms and Management of a Chronic Cutaneous Inflammatory Condition.

Int J Mol Sci 2016 Sep 15;17(9). Epub 2016 Sep 15.

Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea.

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September 2016

A PGC1α-mediated transcriptional axis suppresses melanoma metastasis.

Nature 2016 09 31;537(7620):422-426. Epub 2016 Aug 31.

Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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September 2016

Linear acanthosis nigricans on the anterior neck: Koebner phenomenon observed in a patient with acanthosis nigricans.

J Dermatol 2017 Jul 29;44(7):843-845. Epub 2016 Aug 29.

Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

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July 2017

Preventive and therapeutic effects of blueberry (Vaccinium corymbosum) extract against DSS-induced ulcerative colitis by regulation of antioxidant and inflammatory mediators.

J Nutr Biochem 2016 Feb 26;28:103-13. Epub 2015 Oct 26.

College of Biomedical & Health Science, Department of Life Science, Konkuk University, Chungju, 380-701, Republic of Korea. Electronic address:

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February 2016

Small-molecule inhibitors of USP7 induce apoptosis through oxidative and endoplasmic reticulum stress in cancer cells.

Biochem Biophys Res Commun 2016 Jan 6;470(1):181-186. Epub 2016 Jan 6.

Department of Biomedical Chemistry, College of Biomedical & Health Science, Konkuk University, Chungju 380-701, Chungbuk, Republic of Korea. Electronic address:

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January 2016

Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation.

Sci Rep 2016 Jan 7;6:18928. Epub 2016 Jan 7.

Department of Biomedical Chemistry, College of Biomedical &Health Science, Konkuk University, Chungju 380-701, Chungbuk, Republic of Korea.

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January 2016

A potential therapeutic effect of saikosaponin C as a novel dual-target anti-Alzheimer agent.

J Neurochem 2016 Mar 21;136(6):1232-1245. Epub 2016 Jan 21.

Severance Integrative Research Institute for Cerebral & Cardiovascular Diseases (SIRIC), Yonsei University College of Medicine, Seoul, Korea.

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March 2016

Apigenin Attenuates Melanoma Cell Migration by Inducing Anoikis through Integrin and Focal Adhesion Kinase Inhibition.

Molecules 2015 Nov 27;20(12):21157-66. Epub 2015 Nov 27.

Department of Life Sciences, College of Biomedical & Health Science, Konkuk University, Chungju 380-701, Korea.

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November 2015

Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress.

Int J Oncol 2016 Jan 11;48(1):399-408. Epub 2015 Nov 11.

Department of Biomedical Chemistry, College of Biomedical and Health Science, Konkuk University, Chungbuk, Chungju 380-701, Republic of Korea.

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January 2016

Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy.

Int J Mol Sci 2015 Nov 10;16(11):26880-913. Epub 2015 Nov 10.

Department of Physical Therapy, College of Biomedical Science & Engineering, Inje University, Gimhae 50834, Korea.

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November 2015

Differential regulation of HIF-3α in LPS-induced BV-2 microglial cells: Comparison and characterization with HIF-1α.

Brain Res 2015 Jun 3;1610:33-41. Epub 2015 Apr 3.

(a)Department of Biotechnology, Konkuk University, Chungju-si 380-701, Republic of Korea. Electronic address:

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June 2015

Inhibition of the Interleukin-11-STAT3 Axis Attenuates Hypoxia-Induced Migration and Invasion in MDA-MB-231 Breast Cancer Cells.

Authors:
Ji-Hong Lim

Korean J Physiol Pharmacol 2014 Oct 17;18(5):391-6. Epub 2014 Oct 17.

Department of Biomedical Chemistry, College of Biomedical & Health Science, Konkuk University, Chungju 380-701, Korea.

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October 2014

PRMT5 is essential for the eIF4E-mediated 5'-cap dependent translation.

Biochem Biophys Res Commun 2014 Oct 16;452(4):1016-21. Epub 2014 Sep 16.

Departments of Pharmacology and Biomedical Science, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Republic of Korea. Electronic address:

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October 2014

Anticancer activity of hispidin via reactive oxygen species-mediated apoptosis in colon cancer cells.

Anticancer Res 2014 Aug;34(8):4087-93

Department of Applied Biochemistry, College of Biomedical & Health Science, Research Institute of Inflammatory Disease, Konkuk University, Chungju, South Korea

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August 2014

Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression.

Nature 2014 Jun 25;510(7506):547-51. Epub 2014 May 25.

1] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA [2] Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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June 2014

Zinc finger and BTB domain-containing protein 3 is essential for the growth of cancer cells.

Authors:
Ji-Hong Lim

BMB Rep 2014 Jul;47(7):405-10

Department of Biomedical Chemistry, College of Biomedical and Health Science, Konkuk University, Chungju 380-701, Korea.

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July 2014

Targeting mitochondrial oxidative metabolism in melanoma causes metabolic compensation through glucose and glutamine utilization.

Cancer Res 2014 Jul 8;74(13):3535-45. Epub 2014 May 8.

Authors' Affiliations: Department of Cancer Biology, Dana-Farber Cancer Institute; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts; and

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July 2014

PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.

Cancer Cell 2013 Mar 14;23(3):287-301. Epub 2013 Feb 14.

Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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March 2013

Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex.

J Biol Chem 2013 Mar 17;288(10):7117-26. Epub 2013 Jan 17.

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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March 2013

Protein arginine methyltransferase 5 is an essential component of the hypoxia-inducible factor 1 signaling pathway.

Biochem Biophys Res Commun 2012 Feb 9;418(2):254-9. Epub 2012 Jan 9.

Department of Pharmacology, Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Republic of Korea.

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February 2012

CITED2 controls the hypoxic signaling by snatching p300 from the two distinct activation domains of HIF-1α.

Biochim Biophys Acta 2011 Dec 8;1813(12):2008-16. Epub 2011 Sep 8.

Department of Pharmacology, Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Chongno-gu, Seoul, Republic of Korea.

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December 2011

von Hippel-Lindau protein adjusts oxygen sensing of the FIH asparaginyl hydroxylase.

Int J Biochem Cell Biol 2011 May 21;43(5):795-804. Epub 2011 Feb 21.

Department of Pharmacology, Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-799, Republic of Korea.

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May 2011

Antihepatoma activity of chaetocin due to deregulated splicing of hypoxia-inducible factor 1α pre-mRNA in mice and in vitro.

Hepatology 2011 Jan 7;53(1):171-80. Epub 2010 Dec 7.

Department of Pharmacology, Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Korea.

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January 2011

CAML promotes prolactin-dependent proliferation of breast cancer cells by facilitating prolactin receptor signaling pathways.

Breast Cancer Res Treat 2011 Nov 3;130(1):19-27. Epub 2010 Dec 3.

Department of Pharmacology, Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, 110-799, Korea.

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November 2011

Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha.

Mol Cell 2010 Jun;38(6):864-78

Department of Pharmacology, Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-799, Korea.

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June 2010

Nutlin-3, an Hdm2 antagonist, inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated inactivation of HIF-1alpha.

Carcinogenesis 2009 Oct 20;30(10):1768-75. Epub 2009 Aug 20.

Department of Pharmacology, Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Korea.

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October 2009

Reactive oxygen species-mediated cyclin D1 degradation mediates tumor growth retardation in hypoxia, independently of p21cip1 and hypoxia-inducible factor.

Cancer Sci 2008 Sep 4;99(9):1798-805. Epub 2008 Jul 4.

Department of Pharmacology, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-799, Korea.

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September 2008

Hypoxia-inducible factor-1alpha obstructs a Wnt signaling pathway by inhibiting the hARD1-mediated activation of beta-catenin.

Cancer Res 2008 Jul;68(13):5177-84

Department of Pharmacology, Seoul National University College of Medicine, Chongno-gu, Seoul, Korea.

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July 2008

ATP6V0C competes with von Hippel-Lindau protein in hypoxia-inducible factor 1alpha (HIF-1alpha) binding and mediates HIF-1alpha expression by bafilomycin A1.

Mol Pharmacol 2007 Mar 18;71(3):942-8. Epub 2006 Dec 18.

Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-799, Korea.

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March 2007

Human arrest defective 1 acetylates and activates beta-catenin, promoting lung cancer cell proliferation.

Cancer Res 2006 Nov;66(22):10677-82

Cancer Research Institute and Departments of Pharmacology and Physiology, Seoul National University College of Medicine, Seoul, Korea.

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November 2006

Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1alpha.

Mol Pharmacol 2006 Dec 28;70(6):1856-65. Epub 2006 Aug 28.

Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-799, Korea.

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December 2006

Ras-dependent induction of HIF-1alpha785 via the Raf/MEK/ERK pathway: a novel mechanism of Ras-mediated tumor promotion.

Oncogene 2004 Dec;23(58):9427-31

Human Genome Research Institute and Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-799, Korea.

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December 2004