Publications by authors named "Ji Ding"

18 Publications

  • Page 1 of 1

Construction of chitosan scaffolds with controllable microchannel for tissue engineering and regenerative medicine.

Mater Sci Eng C Mater Biol Appl 2021 Jul 13;126:112178. Epub 2021 May 13.

College of Life Sciences, Key Laboratory of Bioactive Materials (Ministry of Education), State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China. Electronic address:

Microchannels are effective means of enabling the functional performance of tissue engineering scaffolds. Chitosan, a partial deacetylation derivative of chitin, exhibiting excellent biocompatibility, has been widely used in clinical practice. However, development of chitosan scaffolds with controllable microchannels architecture remains an engineering challenge. Here, we generated chitosan scaffolds with adjustable microchannel by combining a 3D printing microfiber templates-leaching method and a freeze-drying method. We can precisely control the arrangement, diameter and density of microchannel within chitosan scaffolds. Moreover, the integrated bilayer scaffolds with the desired structural parameters in each layer were fabricated and exhibited no delamination. The flow rate and volume of the simulated fluid can be modulated by diverse channels architecture. Additionally, the microchannel structure promoted cell survival, proliferation and distribution in vitro, and improved cell and tissue ingrowth and vascular formation in vivo. This study opens a new road for constructing chitosan scaffolds, and can further extend their application scope across tissue engineering and regenerative medicine.
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http://dx.doi.org/10.1016/j.msec.2021.112178DOI Listing
July 2021

Impact of acute kidney injury on in-hospital outcomes in Chinese patients with community acquired pneumonia.

BMC Pulm Med 2021 May 1;21(1):143. Epub 2021 May 1.

Department of Nephrology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, 210006, Jiangsu, China.

Background: Acute kidney injury (AKI) is a frequent complication of community acquired pneumonia (CAP). However, the impact of AKI on in-hospital outcomes of patients with CAP in the Chinese population remains unclear.

Methods: Patients diagnosed with CAP were evaluated in this retrospective observational study. Multiple Cox regression models were employed to identify the association between AKI and in-hospital mortality and 30-day mortality, respectively.

Results: A total of 4213 patients were recruited; 950 (22.5%) patients were diagnosed with AKI. Independent risk factors for AKI were age, male gender, hypertension, cardiac dysfunction, diabetes, chronic kidney disease, acute respiratory failure, use of diuretics, use of vasoactive drugs, and CURB-65. Cox proportional hazards regression revealed AKI, use of angiotensin receptor blocker, hypertension, CURB-65, acute respiratory failure, and use of vasoactive drugs to be independent risk factors for both in-hospital and 30-day mortality. Compared to patients without AKI, those suffering AKI were found to have 1.31-fold (HR 1.31, 95% CI, 1.04-1.66; P = 0.023) and 1.29-fold (HR 1.29, 95% CI, 1.02-1.62; P = 0.033) increased in-hospital and 30-day mortality risks, respectively. In addition, patients with AKI were likely to require admission to intensive care unit (ICU) (42.9% versus 11.4%; P < 0.001), mechanical ventilation (33.8% versus 9.3%; P < 0.001), invasive mechanical ventilation (25.9% versus 5.8%; P < 0.001), non-invasive mechanical ventilation (25.4% versus 7.1%; P < 0.001), and experienced a longer duration of hospital stay (14 days versus 10 days; P < 0.001) than those without AKI. However, no significant difference in ICU stay (11 days versus 10 days; P = 0.099) and duration of mechanical ventilation (8 days versus 8 days; P = 0.369) between AKI and non-AKI groups was found.

Conclusion: AKI was common in Chinese patients with CAP. Patients with CAP who developed AKI had worse in-hospital outcomes.
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http://dx.doi.org/10.1186/s12890-021-01511-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088559PMC
May 2021

Effect of Different Deposition Pressure on Diamond Films Deposited by Hot Filament Chemical Vapor Deposition.

J Nanosci Nanotechnol 2021 Aug;21(8):4512-4518

Global Frontier R&D Center for Hybrid Interface Materials, Pusan National University, Busan 46241, South Korea.

A hot filament chemical vapor deposition (HFCVD) method was adopted to deposit diamond films at deposition pressures ranging from 2-6 kPa. The effects of deposition pressure on the deposition rate, phase structure, and microstructure of diamond films were investigated. The surface morphology, grain size, micro-structure, and growth rate of the diamond films were analyzed using scanning electron microscopy, X-ray diffraction (XRD), and Raman spectrometry. The experimental results showed that granules on the surface exhibited increasingly compact structure with increasing deposition pressure. The diamond films deposited at various pressures have good compactness, and the particles on the film surfaces are arranged in an ordered manner. All films exhibited orientation along the (111) plane, which was the significant characteristic XRD peak of each diamond film. The (111) peak intensity was the strongest for the film prepared at 2 kPa deposition pressure. Overall, the deposition rate and grain size decreased with increasing deposition pressure, provided other deposition conditions remained unchanged. However, the densification of the microstructure and the nucleation density increased with increasing deposition pressure. Secondary nucleation became more pronounced as deposition pressure increased, and grain size decreased as nucleation density increased.
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http://dx.doi.org/10.1166/jnn.2021.19435DOI Listing
August 2021

Biomimetic angle-ply multi-lamellar scaffold for annulus fibrosus tissue engineering.

J Mater Sci Mater Med 2020 Jul 23;31(8):67. Epub 2020 Jul 23.

Tianjin Medical University, Tianjin, PR China.

Constructing a biomimetic scaffold that replicates the complex architecture of intervertebral disc annulus fibrosus (AF) remains a major goal in AF tissue engineering. In this study, a biomimetic angle-ply multi-lamellar polycaprolactone/silk fibroin (PCL/SF) AF scaffold was fabricated. Wet-spinning was used to obtain aligned PCL/SF microfiber sheets, and these were excised into strips with microfibers aligned at +30° or -30° relative to the strip long axis. This was followed by stacking two strips with opposing fiber alignment and wrapping them concentrically around a mandrel. Our results demonstrated that the scaffold possessed spatial structure and mechanical properties comparable to natural AF. The scaffold supported rabbit AF cells adhesion, proliferation, infiltration and guided oriented growth and extracellular matrix deposition. In conclusion, our angle-ply multi-lamellar scaffold offers a potential solution for AF replacement therapy and warrants further attention in future investigations.
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http://dx.doi.org/10.1007/s10856-020-06404-7DOI Listing
July 2020

[SLFN14 inhibits LINE-1 transposition activity].

Yi Chuan 2020 Jul;42(7):669-679

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Long interspersed nuclear element-1 (LINE-1) is the only active autonomous transposon in the human genome. Its transposition frequently induces host genome instability, leading to a variety of genetic diseases, including cancers. The host factors play important roles in inhibiting LINE-1 retrotransposition. As an important component of the immune system, the host factor SLFN14 has antiviral activity. Our laboratory shows that SLFN14 possesses potent inhibitory activity against LINE-1 retrotransposition. To explore the potential mechanism of SLFN14 inhibition, we analyzed its effects on transcription, translation, reverse transcription and insertion in the LINE-1 replication cycle. We confirmed that SLFN14 could suppress the LINE-1 mRNA level by affecting its transcription and degradation, thereby diminishing the protein and cDNA levels of LINE-1, which eventually block the LINE-1 retrotransposition. Further, by mapping the active domains of SLFN14, we found its inhibitory activity on LINE-1 being closely related to its endoribonuclease and ribosome binding domains. These results demonstrate the mechanism of SLFN14 in regulating LINE-1 replication, which further provide new insights for improving the regulation network of host factors for controlling genomic instability caused by LINE-1 replication.
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http://dx.doi.org/10.16288/j.yczz.20-081DOI Listing
July 2020

Correlation between C slope and cervical lordosis in patients after expansive open-door laminoplasty.

Br J Neurosurg 2020 Aug 16;34(4):419-422. Epub 2020 Apr 16.

No. 1 Department of Spine Surgery, Tianjin Union Medical Center, Tianjin, China.

To investigate the correlation between C slope and cervical lordosis in patients after expansive open-door laminoplasty (EOLP). We retrospectively analyzed 57 patients who underwent EOLP between June 2013 and January 2017 in the Department of Spinal Surgery of our hospital. The operation time, intraoperative blood loss and follow-up time were recorded. The C slope, C sagittal vertical axis, and C Cobb angle were measured anteroposterior radiograph of the cervical spine preoperatively and postoperatively. All patients were divided into two groups according to the preoperative C slope (C slope ≤20° group and C slope >20° group). The amount of intraoperative bleeding was 220.2 ± 180.9ml, and the operation time was 143.4 ± 51.2min. The average follow-up time was 24.9 ± 10.3months (range12-48 months). The C Cobb angle was 13.49 ± 10.46°at the final follow-up, which was significantly lower than that preoperatively ( = .026). But, The C slope and C sagittal vertical axis showed no significant difference between preoperatively and postoperatively. Preoperative and postoperative C slope and C Cobb angle were positively correlated to age and significant difference was observed. In the group of C slope >20°, significant difference was observed in term of the change of the C Cobb angle and CSVA postoperatively ( = .009 and = .020). However, there was no statistically significant difference detected in these two parameters in the group of C slope ≤20°. This study indicated that C slope could be used as an indicator of the change in the curvature of the cervical spine after EOLP. The loss of cervical curvature after surgery was prone to occur when C slope was greater than 20°, which should be noted in clinical practice.
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http://dx.doi.org/10.1080/02688697.2020.1751066DOI Listing
August 2020

A Multisensor Data Fusion Method Based on Gaussian Process Model for Precision Measurement of Complex Surfaces.

Sensors (Basel) 2020 Jan 3;20(1). Epub 2020 Jan 3.

School of Mechanical Engineering & Automation, Beihang University, Beijing 100083, China.

As multisensor measurement technology is rapidly applied in industrial production, one key issue is the data fusion procedure by combining several datasets from multiple sensors to obtain the overall geometric measurement. In this paper, a multisensor data fusion method based on a Gaussian process model is proposed for complex surface measurements. A robust surface registration method based on the adaptive distance function is firstly used to unify the coordinate systems of different measurement datasets. By introducing an adjustment model, the residuals between several independent datasets from different sensors are then approximated to construct a Gaussian process model-based data fusion system. The proposed method is verified through both simulation verification and actual experiments, indicating that the proposed method can fuse multisensor measurement datasets with better fusion accuracy and faster computational efficiency compared to the existing method.
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http://dx.doi.org/10.3390/s20010278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982780PMC
January 2020

Circular RNA DLGAP4 is down-regulated and negatively correlates with severity, inflammatory cytokine expression and pro-inflammatory gene miR-143 expression in acute ischemic stroke patients.

Int J Clin Exp Pathol 2019 1;12(3):941-948. Epub 2019 Mar 1.

Department of Neurology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.

This study aimed to investigate the expression of circular RNA DLGAP4 (circ-DLGAP4) and its correlation with severity, inflammation, inflammatory cytokine levels as well as microRNA-143 (miR-143) expression in acute ischemic stroke (AIS) patients. One hundred and seventy AIS patients and 170 non-AIS controls were enrolled in this study. PBMC and serum from all participants were collected. Circ-DLGAP4 and miR-143 expression in PBMC were detected by qPCR, and TNF-α, IL-1β, IL-6, IL-8, IL-17 as well as IL-22 expressions in serum were detected by ELISA. The information of CRP, ESR, and National Institutes of Health Stroke Scale (NIHSS) score of AIS patients was collected. PBMC circ-DLGAP4 was down-regulated in AIS patients compared with controls, and ROC curve analysis disclosed that PBMC circ-DLGAP expression had good value in predicting lower AIS risk with area under curve 0.816. Spearman's rank correlation test showed that PBMC circ-DLGAP4 expression negatively correlated with NIHSS score and CRP level in AIS patients. In addition, PBMC circ-DLGAP4 level also was negatively associated with serum expressions of TNF-α, IL-6, IL-8 as well as IL-22. Moreover, PBMC circ-DLGAP4 expression was negatively correlated with PBMC miR-143, and PBMC miR-143 was positively associated with NIHSS score, CRP, ESR, TNF-α, IL-1β, IL-6, IL-8, IL-17, as well as IL-22 levels. Circulating circ-DLGAP4 could serve as a novel biomarker for diagnosis and disease surveillance of AIS and is negatively correlated with inflammation and miR-143 expression in AIS patients.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945178PMC
March 2019

Potential protein biomarkers for systemic lupus erythematosus determined by bioinformatics analysis.

Comput Biol Chem 2019 Dec 31;83:107135. Epub 2019 Oct 31.

Department of Rheumatology, Affiliated Hospital of Nantong University, No. 20, XiSi Road, Nantong, Jiangsu Province, 226001, PR China. Electronic address:

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder, and its pathogenesis in males and in cases without accompanying lupus nephritis (LN) is not fully understood. In this study, we identified 90 (82 up- and 8 downregulated) differentially expressed genes (DEGs) common to female LN, female LN and male LN using the GSE65391 and GSE49454 gene expression datasets from Gene Expression Omnibus database (GEO). The protein-protein interaction (PPI) network of 70 DEGs was constructed using STRING and cytoscape, and the Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis showed that the PPI network was significantly enriched in defense response to virus, cytosol, protein binding and measles. Sixteen hubgenes were identified from this PPI network, and Literature Mining Gene Networks molecular of GenCLiP 2.0 showed strong interaction between STAT1, DDX58 and IFIT1. Enrichment analysis of hubgenes in published literature showed the involvement of immune response and interferon-related genes in the pathogenesis of SLE. In addition, the transcription factors STAT1 & 2 and IRF6 & 9 had high Normalized Enrichment Score (NES). The 70 DEGs with PPI network and 16 hubgenes are potential biomarkers of SLE, and can help improve diagnosis and develop individualized therapies.
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http://dx.doi.org/10.1016/j.compbiolchem.2019.107135DOI Listing
December 2019

Elevated serum levels of brain-derived neurotrophic factor and miR-124 in acute ischemic stroke patients and the molecular mechanism.

3 Biotech 2019 Nov 5;9(11):386. Epub 2019 Oct 5.

Department of Neurology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, No 1111 of XianXia Road, Shanghai, 200335 China.

Brain-derived neurotrophic factor (BDNF) and microRNAs (miRNAs) play a significant role in the pathogenesis of acute ischemic stroke (AIS). The present study investigates the elevated expression of BDNF and miR-124 in AIS patients. In the present study, serum samples from AIS patients and healthy controls were collected to determine the regulatory role and mechanism of operation of BDNF and to determine the regulatory miRNAs involved in AIS. Using bioinformatics analysis, we identified putative and regulatory miR-124. The effect of miR-124 on BDNF expression was examined in human neuronal cell lines. Moreover, the function of miR-124 in regulating BDNF was analyzed by assessing the serum level of BDNF in both AIS patients and healthy controls. The results indicate that the BDNF level of AIS patients is very low compared with that of controls. In contrast, real-time polymerase chain reaction (RT-PCR) data revealed a very high serum level of miR-124 in AIS patients relative to healthy individuals. The associations of the National Institutes of Health (NIH) stroke scale (NIHSS) score with BDNF and BDNF-related miR-124 serum levels were calculated using Pearson's/Spearman's correlation coefficient. The findings revealed a negative correlation between NIHSS score and BDNF level, whereas a positive correlation was observed between NIHSS score and miR-124. In addition, the relationship between serum BDNF and miR-124 was negative in AIS patients. In conclusion, this study provides strong evidence that serum BDNF and the BDNF-regulatory miR-124 may serve as molecular markers for AIS.
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http://dx.doi.org/10.1007/s13205-019-1914-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778548PMC
November 2019

Intracranial Atherosclerotic Disease-Related Acute Middle Cerebral Artery Occlusion Can Be Predicted by Diffusion-Weighted Imaging.

Front Neurosci 2019 29;13:903. Epub 2019 Aug 29.

Department of Interventional Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.

The differentiation of large vessel occlusion caused by intracranial atherosclerotic stenosis (ICAS) or intracranial embolism significantly impacts the course of treatment (i.e., intravenous thrombolysis versus mechanical thrombectomy) for acute cerebral infarction. Currently, there is no objective evidence to indicate ICAS-related middle cerebral artery M1 segment occlusion before treatment. In cases of ICAS, it is often observed that the infarct core caused by ICAS-related M1 segment middle cerebral artery occlusion (MCAO) is located in deeper parts of the brain (basal ganglia or semiovoid region). To evaluate whether the location of the infarct core, identified using diffusion-weighted imaging (DWI), can be used to differentiate ICAS from intracranial embolism. Thirty-one consecutive patients diagnosed with acute cerebral infarction caused by middle cerebral artery M1 segment occlusion were retrospectively included based on angiographic findings to distinguish ICAS from embolic occlusion. Patients were divided into two groups based on the location of the infarct core on DWI: in the deep part of the brain (basal ganglia or semiovoid region) or more superficially (i.e., cortex). In 16 patients, the infarct core was mainly in the deep part of the brain on DWI [14 of 16 patients in the ICAS group and only 2 in the non-ICAS group (93.3 vs. 6.7%, respectively; < 0.001)]. The diagnostic sensitivity of DWI for ICAS was 93.3%, with a specificity of 87.5%, a Positive predictive value (PPV) of 87.5%, and an Negative predictive value (NPV) of 93.3%, the accuracy was 88.5%. Intracranial atherosclerotic disease-related acute MCAO can be predicted using DWI.
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http://dx.doi.org/10.3389/fnins.2019.00903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738444PMC
August 2019

Effect of Nitrogen Flow Ratio on Composition, Microstructure, and Mechanical Properties of Cr-B-O-N Films Deposited by Pulsed Direct Current Magnetron Sputtering.

J Nanosci Nanotechnol 2019 Oct;19(10):6826-6833

Global Frontier R&D Center for Hybrid Interface Materials, Pusan National University, Busan 46241, South Korea.

Nano-crystalline CrB₂ and Cr-B-O-N films with various nitrogen flow ratios were deposited using a pulsed direct current (PDC) magnetron sputtering technique. By means of electron probe micro-analysis, X-ray diffraction (XRD), X-ray photoelectron spectroscopy, scanning electron microscopy, high-resolution transmission electron microscopy (HRTEM), and atomic force microscopy, the influences of the nitrogen flow ratio on the phase constituents and microstructures of CrB₂/Cr-B-O-N films were systematically investigated. Mechanical properties including the hardness and elastic modulus were explored by a nano-indentation tester. On increasing the nitrogen flow ratio, the N and O contents in films increased linearly and tended to become saturated, whereas the Cr and B contents decreased. With an increasing nitrogen flow ratio, the microstructure changed from a dense columnar structure to a bulky columnar structure, and then to a fine and stacked dense structure. Meanwhile, the deposition rate also changed with increasing nitrogen flow ratio, owing to the changes in structure. Crystalline phases were observed by the XRD and HRTEM analyses, consisting of several nanometer-size crystallites embedded in an amorphous matrix. The dramatically decreased hardness was attributed to the large fractional volume of the softer amorphous phase BN in films.
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http://dx.doi.org/10.1166/jnn.2019.17127DOI Listing
October 2019

Influence of Cu Content on the Microstructure and Mechanical Properties of Cr-Cu-N Coatings.

Scanning 2018 14;2018:6491279. Epub 2018 Jan 14.

School of Convergence Science, Pusan National University, Busan 609-735, Republic of Korea.

The Cr-Cu-N coatings with various Cu contents (0-25.18 (±0.17) at.%) were deposited on Si wafer and stainless steel (SUS 304) substrates in reactive Ar+N gas mixture by a hybrid coating system combining pulsed DC and RF magnetron sputtering techniques. The influence of Cu content on the coating composition, microstructure, and mechanical properties was investigated. The microstructure of the coatings was significantly altered by the introduction of Cu. The deposited coatings exhibit solid solution structure with different compositions in all of the samples. Addition of Cu is intensively favored for preferred orientation growth along (200) direction by restricting in (111) direction. With increasing Cu content, the surface and cross-sectional morphology of coatings were changed from triangle cone-shaped, columnar feature to broccoli-like and compact glassy microstructure, respectively. The mechanical properties including the residual stress, nanohardness, and toughness of the coatings were explored on the basis of Cu content. The highest hardness was obtained at the Cu content of 1.49 (±0.10) at.%.
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http://dx.doi.org/10.1155/2018/6491279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820591PMC
March 2018

Erratum to: Enhanced Corrosion Resistance of PVD-CrN Coatings by ALD Sealing Layers.

Nanoscale Res Lett 2017 12 2;12(1):319. Epub 2017 May 2.

School of Materials Science and Engineering, Pusan National University, Busan, 46241, South Korea.

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http://dx.doi.org/10.1186/s11671-017-2079-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413459PMC
December 2017

Enhanced Corrosion Resistance of PVD-CrN Coatings by ALD Sealing Layers.

Nanoscale Res Lett 2017 Dec 4;12(1):248. Epub 2017 Apr 4.

School of Materials Science and Engineering, Pusan National University, Busan, 46241, South Korea.

Multilayered hard coatings with a CrN matrix and an AlO, TiO, or nanolaminate-AlO/TiO sealing layer were designed by a hybrid deposition process combined with physical vapor deposition (PVD) and atomic layer deposition (ALD). The strategy was to utilize ALD thin films as pinhole-free barriers to seal the intrinsic defects to protect the CrN matrix. The influences of the different sealing layers added in the coatings on the microstructure, surface roughness, and corrosion behaviors were investigated. The results indicated that the sealing layer added by ALD significantly decreased the average grain size and improved the corrosion resistance of the CrN coatings. The insertion of the nanolaminate-AlO/TiO sealing layers resulted in a further increase in corrosion resistance, which was attributed to the synergistic effect of AlO and TiO, both acting as excellent passivation barriers to the diffusion of corrosive substances.
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http://dx.doi.org/10.1186/s11671-017-2020-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380549PMC
December 2017

Endoplasmic reticulum stress contributes to acetylcholine receptor degradation by promoting endocytosis in skeletal muscle cells.

J Neuroimmunol 2016 Jan 26;290:109-14. Epub 2015 Nov 26.

Shanghai Institute of Immunology, Institutes of Medical Sciences, Shanghai Jiaotong University School of Medicine (SJTUSM), Shanghai 200025, China; Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & SJTUSM, Shanghai 200031, China. Electronic address:

After binding by acetylcholine released from a motor neuron, a nicotinic acetylcholine receptor at the neuromuscular junction produces a localized end-plate potential, which leads to muscle contraction. Improper turnover and renewal of acetylcholine receptors contributes to the pathogenesis of myasthenia gravis. In the present study, we demonstrate that endoplasmic reticulum (ER) stress contributes to acetylcholine receptor degradation in C2C12 myocytes. We further show that ER stress promotes acetylcholine receptor endocytosis and lysosomal degradation, which was dampened by blocking endocytosis or treating with lysosome inhibitor. Knockdown of ER stress proteins inhibited acetylcholine receptor endocytosis and degradation, while rescue assay restored its endocytosis and degradation, confirming the effects of ER stress on promoting endocytosis-mediated degradation of junction acetylcholine receptors. Thus, our studies identify ER stress as a factor promoting acetylcholine receptor degradation through accelerating endocytosis in muscle cells. Blocking ER stress and/or endocytosis might provide a novel therapeutic approach for myasthenia gravis.
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http://dx.doi.org/10.1016/j.jneuroim.2015.11.024DOI Listing
January 2016

Clinical significance of joint detection of mALB and NAG for early kidney damage in burn patients.

Minerva Chir 2016 Jun 26;71(3):168-72. Epub 2015 Jun 26.

Department of Plastic Surgery at the Xuzhou Central Hospital, Xuzhou, China -

Background: The aim of this study was to study the clinical significance of joint detection of mALB and NAG in early kidney damage in burn patients.

Methods: Forty-five burn patients of different degrees were selected and divided into mild, moderate, severe, and heavy burns, and normal healthy controls according to their severity. Their b2- macroglobulin (b2-MG), a1-macroglobulin (a1-MG), mALB and N-acetyl-b-D-NAG were tested for 3 days, 1 week, 2 weeks, 4 weeks after the burn, respectively.

Results: The urine concentration change b2-MG, a1-MG, MALB, and NAG are related to the area, depth and degree of the burn. The more serious the burn is, the higher the levels of mALB and NAG (P<0.001 or P<0.01) is.

Conclusions: Early detection of mALB and NAG is helpful for early kidney damage diagnosis in burn patients to prevent further complications.
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June 2016

Designing and optimizing a healthcare kiosk for the community.

Appl Ergon 2015 Mar 6;47:157-69. Epub 2014 Oct 6.

Research Institute of Information Technology, Tsinghua University, Beijing, China.

Investigating new ways to deliver care, such as the use of self-service kiosks to collect and monitor signs of wellness, supports healthcare efficiency and inclusivity. Self-service kiosks offer this potential, but there is a need for solutions to meet acceptable standards, e.g. provision of accurate measurements. This study investigates the design and optimization of a prototype healthcare kiosk to collect vital signs measures. The design problem was decomposed, formalized, focused and used to generate multiple solutions. Systematic implementation and evaluation allowed for the optimization of measurement accuracy, first for individuals and then for a population. The optimized solution was tested independently to check the suitability of the methods, and quality of the solution. The process resulted in a reduction of measurement noise and an optimal fit, in terms of the positioning of measurement devices. This guaranteed the accuracy of the solution and provides a general methodology for similar design problems.
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http://dx.doi.org/10.1016/j.apergo.2014.08.018DOI Listing
March 2015
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