Jesus F Bermejo-Martin

Jesus F Bermejo-Martin

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Jesus F Bermejo-Martin

Jesus F Bermejo-Martin

Publications by authors named "Jesus F Bermejo-Martin"

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Current gaps in sepsis immunology: new opportunities for translational research.

Lancet Infect Dis 2019 Oct 17. Epub 2019 Oct 17.

Hospital Universitario Río Hortega, Valladolid, Spain; Group for Biomedical Research in Sepsis, Instituto de Investigación Biomédica de Salamanca, Salamanca, Spain; Centro de Investigación Biomedica En Red-Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(19)30567-5DOI Listing
October 2019

Simultaneous Depression of Immunological Synapse and Endothelial Injury is Associated with Organ Dysfunction in Community-Acquired Pneumonia.

J Clin Med 2019 Sep 6;8(9). Epub 2019 Sep 6.

Centro de Investigación Biomédica En Red-Enfermedades Respiratorias (CibeRes, 58 CB06/06/0028), Instituto de salud Carlos III (ISCIII), Av. de Monforte de Lemos, 5, 59 28029 Madrid, Spain.

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https://www.mdpi.com/2077-0383/8/9/1404
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http://dx.doi.org/10.3390/jcm8091404DOI Listing
September 2019

Lymphopenic community-acquired pneumonia is associated with a dysregulated immune response and increased severity and mortality.

J Infect 2019 Jun 6;78(6):423-431. Epub 2019 Apr 6.

Center for Biomedical Research Network in Respiratory Diseases (CIBERES, CB06/06/0028), Madrid, Spain; Pneumology Department, Hospital Clínic / Institut D'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.jinf.2019.04.006DOI Listing
June 2019

Lymphocytopenia as a Predictor of Mortality in Patients with ICU-Acquired Pneumonia.

J Clin Med 2019 Jun 13;8(6). Epub 2019 Jun 13.

Pneumology Department, Respiratory Institute (ICR), Hospital Clinic of Barcelona - Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) - University of Barcelona, Ciber de Enfermedades Respiratorias (CIBERES), ICREA Academia, 08036 Barcelona, Spain.

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http://dx.doi.org/10.3390/jcm8060843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617552PMC
June 2019

Impact of Lymphocyte and Neutrophil Counts on Mortality Risk in Severe Community-Acquired Pneumonia with or without Septic Shock.

J Clin Med 2019 May 27;8(5). Epub 2019 May 27.

Laboratory of Biomedical Research in Sepsis (BioSepsis), Hospital Clínico Universitario de Valladolid, Instituto de Investigación Biomédica de Salamanca (IBSAL), 37007 Salamanca, Spain.

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http://dx.doi.org/10.3390/jcm8050754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572378PMC
May 2019

Composed endotypes to guide antibiotic discontinuation in sepsis.

Crit Care 2019 Apr 24;23(1):140. Epub 2019 Apr 24.

Group for Biomedical Research in Sepsis (BioSepsis), Hospital Clínico Universitario de Valladolid/IECSCYL, Av. Ramón y Cajal, 3, 47003, Valladolid, Spain.

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http://dx.doi.org/10.1186/s13054-019-2439-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482544PMC
April 2019

Shared Features of Endothelial Dysfunction between Sepsis and Its Preceding Risk Factors (Aging and Chronic Disease).

J Clin Med 2018 Oct 30;7(11). Epub 2018 Oct 30.

Group for Biomedical Research in Sepsis (Bio∙Sepsis), Hospital Clínico Universitario de Valladolid/IECSCYL, Av. Ramón y Cajal, 3, 47003 Valladolid, Spain.

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http://dx.doi.org/10.3390/jcm7110400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262336PMC
October 2018

New Organ Failure as an Alternative Endpoint to Develop Diagnostic Criteria for Sepsis.

Chest 2018 05;153(5):1278

Servei de Medicina Intensiva, Hospital de Mataró, Mataró, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.chest.2017.11.046DOI Listing
May 2018

Pre-sepsis: A necessary concept to complete the SEPSIS-3 picture?

J Crit Care 2018 04 29;44:148. Epub 2017 Oct 29.

Group for Biomedical research in Sepsis (Bio Sepsis), Hospital Clínico Universitario de Valladolid/IECSCYL, Av. Ramón y Cajal, 3, 47003 Valladolid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jcrc.2017.10.041DOI Listing
April 2018

Immunological profiling to assess disease severity and prognosis in community-acquired pneumonia.

Lancet Respir Med 2017 12;5(12):e35-e36

Department of Pneumology, Institut Clinic del Tórax, Hospital Clinic of Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona-SGR 911- Ciber de Enfermedades Respiratorias (Ciberes), Barcelona, Spain.

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http://dx.doi.org/10.1016/S2213-2600(17)30444-7DOI Listing
December 2017

Lymphopenic Community Acquired Pneumonia (L-CAP), an Immunological Phenotype Associated with Higher Risk of Mortality.

EBioMedicine 2017 Oct 21;24:231-236. Epub 2017 Sep 21.

Pulmonology Service, University and Polytechnic Hospital La Fe, Ciber de Enfermedades Respiratorias (Ciberes), Avinguda de Fernando Abril Martorell, 106, 46026 València, Spain.

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http://dx.doi.org/10.1016/j.ebiom.2017.09.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652132PMC
October 2017

Pulmonary transcriptomic responses indicate a dual role of inflammation in pneumonia development and viral clearance during 2009 pandemic influenza infection.

PeerJ 2017 11;5:e3915. Epub 2017 Oct 11.

Laboratory of Biomedical Research in Sepsis (BIOSEPSIS), Hospital Clínico Universitario de Valladolid, Instituto de Estudios de Ciencias de la Salud de Castilla y León (IECSCYL), Valladolid, Spain.

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http://dx.doi.org/10.7717/peerj.3915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640978PMC
October 2017

Characterizing Systemic Immune Dysfunction Syndrome to Fill in the Gaps of SEPSIS-2 and SEPSIS-3 Definitions.

Chest 2017 02;151(2):518-519

Grupo de Investigación Clínica en Infección e Inmunidad, Hospital Clínico Universitario/IECSCYL, Valladolid, Spain.

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http://dx.doi.org/10.1016/j.chest.2016.11.047DOI Listing
February 2017

IgG2 as an independent risk factor for mortality in patients with community-acquired pneumonia.

J Crit Care 2016 10 13;35:115-9. Epub 2016 May 13.

Unidad Medicina Intensiva, Hospital de Mataró, Barcelona, Spain; Universitat Autònoma de Barcelona, Barcelona, Spain; Ciber Enfermedades Respiratorias (CIBERES), Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jcrc.2016.05.005DOI Listing
October 2016

Procalcitonin cannot be used as a biomarker of infection in heart surgery patients with acute kidney injury.

J Crit Care 2016 06 15;33:233-9. Epub 2016 Jan 15.

BioCritic. Group for biomedical Research in Critical care Medicine, Valladolid, Spain; Department of Anesthesiology and Reanimation, Hospital Clinico Universitario de Valladolid, Valladolid, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S08839441160001
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http://dx.doi.org/10.1016/j.jcrc.2016.01.015DOI Listing
June 2016

Defining immunological dysfunction in sepsis: A requisite tool for precision medicine.

J Infect 2016 May 3;72(5):525-36. Epub 2016 Feb 3.

Grupo de Investigación Biomédica en Cuidados Críticos (BioCritic), Hospital Clínico Universitario de Valladolid, Avenida Ramón y Cajal, 3, 47005 Valladolid, Spain; Servicio de Anestesiología y Reanimación, Hospital Clínico Universitario de Valladolid, SACYL, Avenida Ramón y Cajal, 3, 47005 Valladolid, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01634453160002
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http://dx.doi.org/10.1016/j.jinf.2016.01.010DOI Listing
May 2016

Predicting cardiac surgery-associated acute kidney injury: The CRATE score.

J Crit Care 2016 Feb 6;31(1):130-8. Epub 2015 Nov 6.

Department of Anesthesiology and Reanimation, Hospital Clinico Universitario de Valladolid, Valladolid, Spain; Immunity, Risk of Infection and Sepsis group (IRIS), Hospital Clínico Universitario de Valladolid, Valladolid, Spain.

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http://dx.doi.org/10.1016/j.jcrc.2015.11.004DOI Listing
February 2016

Endogenous immunoglobulins and sepsis: New perspectives for guiding replacement therapies.

Int J Antimicrob Agents 2015 Dec 3;46 Suppl 1:S25-8. Epub 2015 Nov 3.

4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2015.10.013DOI Listing
December 2015

Preventing sepsis.

Lancet Infect Dis 2015 Nov;15(11):1259-60

Grupo de Investigación Biomédica en Cuidados Críticos (BioCritic), Hospital Clínico Universitario de Valladolid, SACYL & IECSCYL, 47005 Valladolid, Spain; Servicio de Anestesiología y Reanimación, Hospital Clínico Universitario de Valladolid, SACYL, Valladolid, Spain.

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http://dx.doi.org/10.1016/S1473-3099(15)00374-6DOI Listing
November 2015

Endogenous IgG hypogammaglobulinaemia in critically ill adults with sepsis: systematic review and meta-analysis.

Intensive Care Med 2015 Aug 14;41(8):1393-401. Epub 2015 May 14.

Department of Critical Care Medicine, Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, 1st Floor, East Wing, London, SE17EH, UK,

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http://dx.doi.org/10.1007/s00134-015-3845-7DOI Listing
August 2015

Transcriptomic correlates of organ failure extent in sepsis.

J Infect 2015 May 31;70(5):445-56. Epub 2014 Dec 31.

Grupo de Investigación Biomédica en Cuidados Críticos (BioCritic), Hospital Clínico Universitario de Valladolid, SACYL/IECSYL, Avenida Ramón y Cajal, 3, 47005 Valladolid, Spain; Servicio de Anestesiología, Hospital Clínico Universitario de Valladolid, SACYL, Avenida Ramón y Cajal, 3, 47005 Valladolid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2014.12.010DOI Listing
May 2015

Immunoinformatics and systems biology in personalized medicine.

Methods Mol Biol 2014 ;1184:457-75

Health and Biomedical Informatics Centre, The University of Melbourne, Level 1, 202 Berkeley Street, Parkville, VIC, 3010, Australia.

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http://dx.doi.org/10.1007/978-1-4939-1115-8_25DOI Listing
March 2015

The original sins of clinical trials with intravenous immunoglobulins in sepsis.

Crit Care 2015 Feb 26;19:90. Epub 2015 Feb 26.

Group of Biomedical Research in Critical Care Medicine (BioCritic), Hospital Clínico Universitario de Valladolid, Avda. Ramón y Cajal, 3. 47005, Valladolid, Spain.

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http://dx.doi.org/10.1186/s13054-015-0793-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4343266PMC
February 2015

Hyperimmune serum from healthy vaccinated individuals for Ebola virus disease?

Lancet Glob Health 2014 Dec 30;2(12):e686. Epub 2014 Oct 30.

Hospital Clínico Universitario de Valladolid, SACYL/IECSYL, 47005 Valladolid, Spain. Electronic address:

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http://dx.doi.org/10.1016/S2214-109X(14)70341-9DOI Listing
December 2014

Inflammation and infection in critical care medicine.

Mediators Inflamm 2014 2;2014:456256. Epub 2014 Feb 2.

Department of Microbiology & Immunology, Yerkes National Primate Research Center, Emory University, Rm 3028 Emory Vaccine Center Building 954, Gatewood Road NE, Atlanta, GA 30329, USA.

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http://www.hindawi.com/journals/mi/2014/456256/
Publisher Site
http://dx.doi.org/10.1155/2014/456256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929288PMC
October 2014

Cytokine profiles linked to fatal outcome in infective prosthetic valve endocarditis.

APMIS 2014 Jun 30;122(6):526-9. Epub 2013 Sep 30.

Department of Cardiovascular Surgery, Hospital Universitario de La Princesa, Madrid, Spain; Grupo de Investigación en Sepsis, Valladolid, Spain.

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http://dx.doi.org/10.1111/apm.12189DOI Listing
June 2014

Transcriptomic evidence of impaired immunoglobulin G production in fatal septic shock.

J Crit Care 2014 Apr 2;29(2):307-9. Epub 2013 Dec 2.

Laboratorio de Ciencias Biomédicas en Investigación Clínica (CBIC), Hospital Clínico Universitario de Valladolid, IECSCYL-SACYL, Valladolid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jcrc.2013.11.020DOI Listing
April 2014

IgA level in plasma as a differential factor for influenza infection in severe viral pneumonia.

J Clin Virol 2014 Feb 12;59(2):135-6. Epub 2013 Dec 12.

Unidad de Investigación Biomédica, Hospital Clínico Universitario de Valladolid (ibC), SACYL/IECSCYL, Avda Ramón y Cajal 3, 47005 Valladolid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jcv.2013.12.003DOI Listing
February 2014

Early levels in blood of immunoglobulin M and natural killer cells predict outcome in nonseptic critically ill patients.

J Crit Care 2013 Dec 15;28(6):1110.e7-1110.e10. Epub 2013 Aug 15.

Critical Care Medicine Service, Hospital Clínico Universitario SACYL/SEMICYUC, Avda Ramón y Cajal 3, Valladolid, Spain; Laboratorio de Investigación Médica Avanzada (IMAV), Unidad de Investigación Biomédica, Hospital Clínico Universitario SACYL, Avda Ramón y Cajal 3, Valladolid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jcrc.2013.06.007DOI Listing
December 2013

Immunomodulatory nanoparticles from elastin-like recombinamers: single-molecules for tuberculosis vaccine development.

Mol Pharm 2013 Feb 24;10(2):586-97. Epub 2013 Jan 24.

Bioforge Group, University of Valladolid , CIBER-BBN, Paseo de Belén 11, 47011 Valladolid, Spain.

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http://dx.doi.org/10.1021/mp300325vDOI Listing
February 2013

Beneficial role of endogenous immunoglobulin subclasses and isotypes in septic shock.

J Crit Care 2012 Dec 22;27(6):616-22. Epub 2012 Oct 22.

Anesthesiology and Reanimation Service, Hospital Clínico Universitario-SACYL, 47005 Valladolid, Spain.

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http://dx.doi.org/10.1016/j.jcrc.2012.08.004DOI Listing
December 2012

MCP-1 in urine as biomarker of disease activity in Systemic Lupus Erythematosus.

Cytokine 2012 Nov 3;60(2):583-6. Epub 2012 Aug 3.

Autoimmunity Unit, Internal Medicine Service, Hospital Clínico Universitario de Valladolid-SACYL, Ramón y Cajal 3, 47005 Valladolid, Spain.

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http://dx.doi.org/10.1016/j.cyto.2012.07.009DOI Listing
November 2012

Immunopathogenesis of 2009 pandemic influenza.

Enferm Infecc Microbiol Clin 2012 Oct;30 Suppl 4:18-24

Unidad de Investigación Médica en Infección e Inmunidad (IMI), Investigación Biomédica del Clínico (ibC), Hospital Clínico Universitario, Valladolid, Spain.

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http://dx.doi.org/10.1016/S0213-005X(12)70100-3DOI Listing
October 2012

Evolution of neutrophil apoptosis in septic shock survivors and nonsurvivors.

J Crit Care 2012 Aug 10;27(4):415.e1-11. Epub 2011 Nov 10.

Department of Anaesthesiology and Intensive Care, Hospital Clínico Universitario de Valladolid, 47005 Valladolid, Spain.

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http://dx.doi.org/10.1016/j.jcrc.2011.09.001DOI Listing
August 2012

Genetic polymorphisms located in genes related to immune and inflammatory processes are associated with end-stage renal disease: a preliminary study.

BMC Med Genet 2012 Jul 20;13:58. Epub 2012 Jul 20.

Unidad de Epidemiología Molecular de Enfermedades Infecciosas, Centro Nacional de Microbiología, Instituto de Salud Carlos III (Campus Majadahonda), Carretera Majadahonda-Pozuelo Km 2,2, Majadahonda, Madrid, Spain.

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http://dx.doi.org/10.1186/1471-2350-13-58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412707PMC
July 2012

Genetic polymorphisms located in TGFB1, AGTR1, and VEGFA genes are associated to chronic renal allograft dysfunction.

Cytokine 2012 Jun 19;58(3):321-6. Epub 2012 Mar 19.

Unidad de Epidemiología Molecular de Enfermedades Infecciosas, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain.

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http://dx.doi.org/10.1016/j.cyto.2012.02.017DOI Listing
June 2012

A combined score of pro- and anti-inflammatory interleukins improves mortality prediction in severe sepsis.

Cytokine 2012 Mar 23;57(3):332-6. Epub 2011 Dec 23.

Critical Care Medicine Service, Hospital Clínico Universitario-SACYL/SEMICYUC, Avda Ramón y Cajal 3, 47005 Valladolid, Spain.

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http://dx.doi.org/10.1016/j.cyto.2011.12.002DOI Listing
March 2012

Ventilator-associated pneumonia is an important risk factor for mortality after major cardiac surgery.

J Crit Care 2012 Feb 18;27(1):18-25. Epub 2011 May 18.

Department of Anaesthesiology and Intensive Care, Hospital Clinico Universitario de Valladolid, Valladolid, Spain.

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http://dx.doi.org/10.1016/j.jcrc.2011.03.008DOI Listing
February 2012

[MCP-1 in urine as biomarker of renal lupus in absence of cytokines, interferon-γ and growth factors].

Reumatol Clin 2010 Nov-Dec;6(6):296-8. Epub 2010 Jun 8.

Unidad de Enfermedades Autoinmunes, Servicio de Medicina Interna, Hospital Clínico Universitario, Valladolid, España.

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http://dx.doi.org/10.1016/j.reuma.2009.09.015DOI Listing
January 2012

[Gene expression profiling in the first twelve weeks of treatment in chronic hepatitis C patients].

Enferm Infecc Microbiol Clin 2011 Oct 30;29(8):573-80. Epub 2011 Jun 30.

Unidad de Investigación en Infección e Inmunidad, Servicio de Microbiología, Hospital Clínico Universitario, IECSCYL, Valladolid, España.

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http://dx.doi.org/10.1016/j.eimc.2011.04.006DOI Listing
October 2011

Pro- and anti-inflammatory responses are regulated simultaneously from the first moments of septic shock.

Eur Cytokine Netw 2011 Jun;22(2):82-7

Anesthesiology and Reanimation Service, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.

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http://dx.doi.org/10.1684/ecn.2011.0281DOI Listing
June 2011

Host response cytokine signatures in viral and nonviral acute exacerbations of chronic obstructive pulmonary disease.

J Interferon Cytokine Res 2011 May 15;31(5):409-13. Epub 2011 Jan 15.

Translational Medicine Program, Infection and Immunity Unit, Microbiology Service, Hospital Clínico Universitario-IECSCYL, Valladolid, Spain.

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http://dx.doi.org/10.1089/jir.2010.0131DOI Listing
May 2011

Prolonged standard treatment for systemic lupus erythematosus fails to normalize the secretion of innate immunity-related chemokines.

Eur Cytokine Netw 2010 Mar;21(1):71-6

Unidad de Enfermedades Autoinmunes, Servicio de Medicina Interna, Hospital Clínico Universitario, Valladolid, Spain.

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http://dx.doi.org/10.1684/ecn.2009.0176DOI Listing
March 2010

Nasopharyngeal aspirate cytokine levels 1 yr after severe respiratory syncytial virus infection.

Pediatr Allergy Immunol 2009 Dec 28;20(8):791-5. Epub 2009 Feb 28.

Servicio de Pediatría, Hospital Clínico Universitario, 47005 Valladolid, Spain.

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http://dx.doi.org/10.1111/j.1399-3038.2009.00868.xDOI Listing
December 2009

Macrolides for the treatment of severe respiratory illness caused by novel H1N1 swine influenza viral strains.

J Infect Dev Ctries 2009 Apr 30;3(3):159-61. Epub 2009 Apr 30.

National Centre of Influenza, Valladolid, Spain.

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April 2009

Gene expression analysis of host innate immune responses during Lethal H5N1 infection in ferrets.

J Virol 2008 Nov 6;82(22):11308-17. Epub 2008 Aug 6.

Division of Immunology, International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong, P. R. China.

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http://dx.doi.org/10.1128/JVI.00691-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573250PMC
November 2008

Human immunopathogenesis of severe acute respiratory syndrome (SARS).

Virus Res 2008 Apr 19;133(1):13-9. Epub 2007 Mar 19.

University Health Network, MaRS Centre, 101 College Street, Toronto, Ontario M5G 1L7, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S016817020700054
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http://dx.doi.org/10.1016/j.virusres.2007.02.014DOI Listing
April 2008

Predominance of Th2 cytokines, CXC chemokines and innate immunity mediators at the mucosal level during severe respiratory syncytial virus infection in children.

Eur Cytokine Netw 2007 Sep 7;18(3):162-7. Epub 2007 Sep 7.

Lab. de Inmunología de Mucosas, Dept. of Pediatrics and Immunology. Universidad de Valladolid, Facultad de Medicina, Ramón y Cajal 7, Valladolid 47005, Spain.

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http://dx.doi.org/10.1684/ecn.2007.0096DOI Listing
September 2007

Analysis of interaction between dendriplexes and bovine serum albumin.

Biomacromolecules 2007 Jul 21;8(7):2059-62. Epub 2007 Jun 21.

Department of General Biophysics, University of Lodz, Lodz, Poland.

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http://dx.doi.org/10.1021/bm070333pDOI Listing
July 2007

Water-soluble carbosilane dendrimers protect phosphorothioate oligonucleotides from binding to serum proteins.

Org Biomol Chem 2007 Jun 14;5(12):1886-93. Epub 2007 May 14.

Laboratorio de Inmunobiología Molecular, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

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http://dx.doi.org/10.1039/b703989aDOI Listing
June 2007