Publications by authors named "Jessica Frankum"

27Publications

Clinical Reversion Analysis Identifies Hotspot Mutations and Predicted Neoantigens Associated with Therapy Resistance.

Cancer Discov 2020 Oct 22;10(10):1475-1488. Epub 2020 Jul 22.

The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-19-1485DOI Listing
October 2020

Modeling Therapy Resistance in -Mutant Cancers.

Mol Cancer Ther 2017 09 15;16(9):2022-2034. Epub 2017 Jun 15.

The CRUK Gene Function Laboratory and The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.

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http://mct.aacrjournals.org/lookup/doi/10.1158/1535-7163.MCT
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http://dx.doi.org/10.1158/1535-7163.MCT-17-0098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157714PMC
September 2017

Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity.

Oncotarget 2015 May;6(13):10746-58

The CRUK Gene Function Laboratory and Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484416PMC
http://dx.doi.org/10.18632/oncotarget.3628DOI Listing
May 2015

Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers.

Cancer Discov 2015 May 13;5(5):488-505. Epub 2015 Mar 13.

Breakthrough Breast Cancer Research Unit, King's College London, London, United Kingdom. Department of Research Oncology, King's Health Partners AHSC, Life Sciences and Medicine, King's College London, London, United Kingdom. The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-14-1092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490184PMC
May 2015

Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity.

Cancer Res 2014 Jan 15;74(1):287-97. Epub 2013 Nov 15.

Authors' Affiliations: The CRUK Gene Function Laboratory, Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-2541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886090PMC
January 2014

Molecular characterisation of cell line models for triple-negative breast cancers.

BMC Genomics 2012 Nov 14;13:619. Epub 2012 Nov 14.

Breakthrough Breast Cancer Research Unit, Guy's Hospital, King's Health Partners AHSC, King's College London School of Medicine, London SE1 9RT, UK.

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http://dx.doi.org/10.1186/1471-2164-13-619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546428PMC
November 2012

Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells.

EMBO Mol Med 2012 Oct 30;4(10):1087-96. Epub 2012 Aug 30.

The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.

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http://embomolmed.embopress.org/cgi/doi/10.1002/emmm.2012012
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http://dx.doi.org/10.1002/emmm.201201250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491838PMC
October 2012

Functional characterization of EMSY gene amplification in human cancers.

J Pathol 2011 Sep 7;225(1):29-42. Epub 2011 Jul 7.

Molecular Pathology Team, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1002/path.2944DOI Listing
September 2011

Searching for synthetic lethality in cancer.

Curr Opin Genet Dev 2011 Feb 20;21(1):34-41. Epub 2011 Jan 20.

The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S0959437X100017
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http://dx.doi.org/10.1016/j.gde.2010.10.009DOI Listing
February 2011