Publications

Epigenetic regulation of EC-SOD expression in aging lung fibroblasts: Role of histone acetylation.
Free Radic Biol Med 2017 Nov 27;112:212-223. Epub 2017 Jul 27.
Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Louisville, Louisville, KY 40202, United States; Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY 40202, United States. Electronic address:


Respiratory Health in Migrant Populations: A Crisis Overlooked.
Ann Am Thorac Soc 2017 Feb;14(2):153-159
10 Division of Pulmonary, Critical Care, and Sleep Disorders, Department of Medicine and Department of Pharmacology, University of Louisville Health Sciences Center and Robley Rex Veterans Affairs Medical Center, Louisville, Kentucky.

Open and closed models of intensive care unit have different influences on infectious complications in a tertiary care center: A retrospective data analysis.
Am J Infect Control 2016 Dec 7;44(12):1744-1746. Epub 2016 Jul 7.
Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Disorders Medicine, University of Louisville, Louisville, KY.

Targeting the Mammalian Target of Rapamycin in Lung Cancer.
Am J Med Sci 2016 Nov 21;352(5):507-516. Epub 2016 Aug 21.
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky; Division of Pulmonary, Critical Care, and Sleep Disorders Medicine, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky; Lousiville Veterans Affairs Medical Center, Louisville, Kentucky. Electronic address:

Lung extracellular matrix and redox regulation.
Redox Biol 2016 Aug 18;8:305-15. Epub 2016 Feb 18.
Department of Medicine, Divisions of Pulmonary, Critical Care and Sleep Disorders and Gastroenterology, Hepatology and Nutrition, University of Louisville, Health Sciences Center, Louisville, KY, United States; Department of Pharmacology & Toxicology, University of Louisville, Health Sciences Center, Louisville, KY, United States; Robley Rex Veterans Affairs Medical Center, Louisville, KY, United States. Electronic address:

Chronic Alcohol Exposure Enhances Lipopolysaccharide-Induced Lung Injury in Mice: Potential Role of Systemic Tumor Necrosis Factor-Alpha.
Alcohol Clin Exp Res 2015 Oct 18;39(10):1978-88. Epub 2015 Sep 18.
Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, Kentucky.

Novel link between prostaglandin E2 (PGE2) and cholinergic signaling in lung cancer: The role of c-Jun in PGE2-induced α7 nicotinic acetylcholine receptor expression and tumor cell proliferation.
Thorac Cancer 2015 Jul 14;6(4):488-500. Epub 2015 Jan 14.
Division of Pulmonary, Critical Care and Sleep Disorders Medicine, Department of Medicine, University of Louisville School of Medicine Louisville, Kentucky, USA ; Louisville Veterans Affairs Medical Center Louisville, Kentucky, USA.


Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.
Carcinogenesis 2015 Jun;36 Suppl 1:S254-96
Department of Surgery, The Ohio State University College of Medicine, The James Comprehensive Cancer Center, Columbus, OH 43210, USA.

Open-access biorepository for idiopathic pulmonary fibrosis. The way forward.
Ann Am Thorac Soc 2014 Oct;11(8):1171-5
1 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan.


Aging promotes pro-fibrotic matrix production and increases fibrocyte recruitment during acute lung injury.
Adv Biosci Biotechnol 2014 Jan;5(1):19-30
Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA, USA ; Division of Pulmonary, Allergy and Critical Care Medicine, Atlanta VAMC, Decatur, GA, USA.


Control of fibroblast fibronectin expression and alternative splicing via the PI3K/Akt/mTOR pathway.
Exp Cell Res 2010 Oct 13;316(16):2644-53. Epub 2010 Jul 13.
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Extracellular matrix influences alveolar epithelial claudin expression and barrier function.
Am J Respir Cell Mol Biol 2010 Feb 7;42(2):172-80. Epub 2009 May 7.
Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Emory University School of Medicine, Whitehead Biomedical Research Building, 615 Michael St., Suite 205, Atlanta, GA 30322, USA.

Activation of peroxisome proliferator-activated receptor beta/delta induces lung cancer growth via peroxisome proliferator-activated receptor coactivator gamma-1alpha.
Am J Respir Cell Mol Biol 2009 Mar 5;40(3):325-31. Epub 2008 Sep 5.
Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Whitehead Bioresearch Building, 615 Michael Street, Suite 205-M, Atlanta, GA 30322, USA.

Rosiglitazone inhibits alpha4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor gamma-independent signals.
Mol Cancer Ther 2009 Jan;8(1):110-8
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Whitehead Bioresearch Building, 615 Michael Street, Suite 205-M, Atlanta, GA 30322, USA.

PPARbeta/delta agonist stimulates human lung carcinoma cell growth through inhibition of PTEN expression: the involvement of PI3K and NF-kappaB signals.
Am J Physiol Lung Cell Mol Physiol 2008 Jun 4;294(6):L1238-49. Epub 2008 Apr 4.
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Whitehead Bioresearch Bldg., 615 Michael St., Suite 205-M, Atlanta, GA 30322, USA.


Extracellular cysteine/cystine redox potential controls lung fibroblast proliferation and matrix expression through upregulation of transforming growth factor-beta.
Am J Physiol Lung Cell Mol Physiol 2007 Oct 20;293(4):L972-81. Epub 2007 Jul 20.
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient mice.
Am J Respir Crit Care Med 2007 Jun 15;175(11):1139-50. Epub 2007 Mar 15.
Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Emory University, 615 Michael Street, Suite 205K, Atlanta, GA 30322, USA.

Baclofen, a GABABR agonist, ameliorates immune-complex mediated acute lung injury by modulating pro-inflammatory mediators.
PLoS One 2015 7;10(4):e0121637. Epub 2015 Apr 7.
Department of Medicine, University of Louisville, Louisville, Kentucky, United States of America; Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, Kentucky, United States of America.

BRCA1 185delAG Mutation Enhances Interleukin-1β Expression in Ovarian Surface Epithelial Cells.
Biomed Res Int 2015 19;2015:652017. Epub 2015 Aug 19.
Department of Pathology & Cell Biology, University of South Florida, Tampa, FL 33612, USA ; Department of Obstetrics & Gynecology, University of South Florida, Tampa, FL 33612, USA ; H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.

Differential Regulation of the Extracellular Cysteine/Cystine Redox State (EhCySS) by Lung Fibroblasts from Young and Old Mice.
Oxid Med Cell Longev 2016 25;2016:1561305. Epub 2016 Aug 25.
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, USA; Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Louisville School of Medicine, Louisville, KY, USA; Robley Rex Veterans Affairs Medical Center, Louisville, KY, USA.

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