Jesper V Olsen

Jesper V Olsen

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Jesper V Olsen

Publications by authors named "Jesper V Olsen"

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Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.

Nucleic Acids Res 2019 Jul 3. Epub 2019 Jul 3.

Department of Cellular and Molecular Medicine, Center for Chromosome Stability and Center for Healthy Aging, University of Copenhagen, Copenhagen 2200, Denmark.

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http://dx.doi.org/10.1093/nar/gkz591DOI Listing
July 2019

Alternative Translation Initiation Generates a Functionally Distinct Isoform of the Stress-Activated Protein Kinase MK2.

Cell Rep 2019 Jun;27(10):2859-2870.e6

Institute of Cell Biochemistry, Hannover Medical School (MHH), Carl-Neuberg-Str. 1, 30625 Hannover, Germany; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.024DOI Listing
June 2019

Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.

Nucleic Acids Res 2019 Jun 10. Epub 2019 Jun 10.

Department of Cellular and Molecular Medicine, Center for Chromosome Stability and Center for Healthy Aging, University of Copenhagen, Copenhagen 2200, Denmark.

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http://dx.doi.org/10.1093/nar/gkz510DOI Listing
June 2019

Protein Aggregation Capture on Microparticles Enables Multipurpose Proteomics Sample Preparation.

Mol Cell Proteomics 2019 May 4;18(5):1027-1035. Epub 2019 Mar 4.

From the ‡The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Denmark;

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http://dx.doi.org/10.1074/mcp.TIR118.001270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495262PMC
May 2019

GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling.

Cell Rep 2019 Mar;26(13):3511-3521.e4

Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.03.006DOI Listing
March 2019

Limits for Resolving Isobaric Tandem Mass Tag Reporter Ions Using Phase-Constrained Spectrum Deconvolution.

J Proteome Res 2018 11 28;17(11):4008-4016. Epub 2018 Sep 28.

The Novo Nordisk Foundation Center for Protein Research , University of Copenhagen , 2200 Copenhagen , Denmark.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.8b00381
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http://dx.doi.org/10.1021/acs.jproteome.8b00381DOI Listing
November 2018

Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma.

Sci Signal 2018 Nov 20;11(557). Epub 2018 Nov 20.

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1126/scisignal.aap9752DOI Listing
November 2018

Quantitative metaproteomics of medieval dental calculus reveals individual oral health status.

Nat Commun 2018 11 20;9(1):4744. Epub 2018 Nov 20.

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen N, Denmark.

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http://www.nature.com/articles/s41467-018-07148-3
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http://dx.doi.org/10.1038/s41467-018-07148-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246597PMC
November 2018

SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability.

Nucleic Acids Res 2018 10;46(18):9484-9495

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1093/nar/gky719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182143PMC
October 2018

Generic Workflow for Mapping of Complex Disulfide Bonds Using In-Source Reduction and Extracted Ion Chromatograms from Data-Dependent Mass Spectrometry.

Anal Chem 2018 07 22;90(13):8202-8210. Epub 2018 Jun 22.

Protein Engineering , Global Research, Novo Nordisk A/S , Novo Nordisk Park , 2760 Måløv , Denmark.

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http://dx.doi.org/10.1021/acs.analchem.8b01603DOI Listing
July 2018

Palaeoproteomic Profiling of Conservation Layers on a 14th Century Italian Wall Painting.

Angew Chem Int Ed Engl 2018 06 26;57(25):7369-7374. Epub 2018 Apr 26.

Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350, Copenhagen, Denmark.

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http://dx.doi.org/10.1002/anie.201713020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032867PMC
June 2018

Molecular basis of Tousled-Like Kinase 2 activation.

Nat Commun 2018 06 28;9(1):2535. Epub 2018 Jun 28.

Structural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41467-018-04941-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023931PMC
June 2018

Large-Scale Phosphoproteomics Reveals Shp-2 Phosphatase-Dependent Regulators of Pdgf Receptor Signaling.

Cell Rep 2018 03;22(10):2784-2796

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Science, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.02.038DOI Listing
March 2018

Benchmarking common quantification strategies for large-scale phosphoproteomics.

Nat Commun 2018 03 13;9(1):1045. Epub 2018 Mar 13.

Novo Nordisk Foundation Center for Protein Research, Proteomics Program, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, 2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41467-018-03309-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849679PMC
March 2018

Performance Evaluation of the Q Exactive HF-X for Shotgun Proteomics.

J Proteome Res 2018 01 20;17(1):727-738. Epub 2017 Dec 20.

The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen , Blegdamsvej 3b, Copenhagen 2200, Denmark.

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http://dx.doi.org/10.1021/acs.jproteome.7b00602DOI Listing
January 2018

Control of endothelial cell tube formation by Notch ligand intracellular domain interactions with activator protein 1 (AP-1).

J Biol Chem 2018 01 1;293(4):1229-1242. Epub 2017 Dec 1.

From the Department of Molecular Cell Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands and

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http://dx.doi.org/10.1074/jbc.M117.819045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787801PMC
January 2018

Conformation-specific anti-Mad2 monoclonal antibodies for the dissection of checkpoint signaling.

MAbs 2016 May-Jun;8(4):689-97. Epub 2016 Mar 17.

a The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark.

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http://dx.doi.org/10.1080/19420862.2016.1160988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966835PMC
November 2017

KIT Induces SRC-Mediated Tyrosine Phosphorylation of MITF and Altered Transcription Program in Melanoma.

Mol Cancer Res 2017 09 5;15(9):1265-1274. Epub 2017 Jun 5.

Division of Translational Cancer Research, Lund Stem Cell Center, Lund University, Medicon Village and Department of Oncology, Skåne University Hospital, Lund, Sweden.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-17-0149DOI Listing
September 2017

Complete Mapping of Complex Disulfide Patterns with Closely-Spaced Cysteines by In-Source Reduction and Data-Dependent Mass Spectrometry.

Anal Chem 2017 06 9;89(11):5949-5957. Epub 2017 May 9.

Protein Engineering, Global Research, Novo Nordisk A/S , Novo Nordisk Park, 2760 Måløv, Denmark.

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http://dx.doi.org/10.1021/acs.analchem.7b00424DOI Listing
June 2017

An Optimized Shotgun Strategy for the Rapid Generation of Comprehensive Human Proteomes.

Cell Syst 2017 06 7;4(6):587-599.e4. Epub 2017 Jun 7.

Proteomics Program, Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2017.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493283PMC
June 2017

Proteomic profiling of archaeological human bone.

R Soc Open Sci 2017 Jun 7;4(6):161004. Epub 2017 Jun 7.

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1098/rsos.161004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493901PMC
June 2017

Phosphoproteomics of Primary Cells Reveals Druggable Kinase Signatures in Ovarian Cancer.

Cell Rep 2017 03;18(13):3242-3256

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382236PMC
March 2017

Proteomics insights into DNA damage response and translating this knowledge to clinical strategies.

Proteomics 2017 02 12;17(3-4). Epub 2016 Dec 12.

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1002/pmic.201600018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333460PMC
February 2017

The ubiquitin ligase Cullin5 regulates NDR1/STK38 stability and NF-κB transactivation.

Sci Rep 2017 02 20;7:42800. Epub 2017 Feb 20.

Novo Nordisk Foundation Center for Protein Research, Department of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.

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http://www.nature.com/articles/srep42800
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http://dx.doi.org/10.1038/srep42800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316984PMC
February 2017

52 Genetic Loci Influencing Myocardial Mass.

Authors:
Pim van der Harst Jessica van Setten Niek Verweij Georg Vogler Lude Franke Matthew T Maurano Xinchen Wang Irene Mateo Leach Mark Eijgelsheim Nona Sotoodehnia Caroline Hayward Rossella Sorice Osorio Meirelles Leo-Pekka Lyytikäinen Ozren Polašek Toshiko Tanaka Dan E Arking Sheila Ulivi Stella Trompet Martina Müller-Nurasyid Albert V Smith Marcus Dörr Kathleen F Kerr Jared W Magnani Fabiola Del Greco M Weihua Zhang Ilja M Nolte Claudia T Silva Sandosh Padmanabhan Vinicius Tragante Tõnu Esko Gonçalo R Abecasis Michiel E Adriaens Karl Andersen Phil Barnett Joshua C Bis Rolf Bodmer Brendan M Buckley Harry Campbell Megan V Cannon Aravinda Chakravarti Lin Y Chen Alessandro Delitala Richard B Devereux Pieter A Doevendans Anna F Dominiczak Luigi Ferrucci Ian Ford Christian Gieger Tamara B Harris Eric Haugen Matthias Heinig Dena G Hernandez Hans L Hillege Joel N Hirschhorn Albert Hofman Norbert Hubner Shih-Jen Hwang Annamaria Iorio Mika Kähönen Manolis Kellis Ivana Kolcic Ishminder K Kooner Jaspal S Kooner Jan A Kors Edward G Lakatta Kasper Lage Lenore J Launer Daniel Levy Alicia Lundby Peter W Macfarlane Dalit May Thomas Meitinger Andres Metspalu Stefania Nappo Silvia Naitza Shane Neph Alex S Nord Teresa Nutile Peter M Okin Jesper V Olsen Ben A Oostra Josef M Penninger Len A Pennacchio Tune H Pers Siegfried Perz Annette Peters Yigal M Pinto Arne Pfeufer Maria Grazia Pilia Peter P Pramstaller Bram P Prins Olli T Raitakari Soumya Raychaudhuri Ken M Rice Elizabeth J Rossin Jerome I Rotter Sebastian Schafer David Schlessinger Carsten O Schmidt Jobanpreet Sehmi Herman H W Silljé Gianfranco Sinagra Moritz F Sinner Kamil Slowikowski Elsayed Z Soliman Timothy D Spector Wilko Spiering John A Stamatoyannopoulos Ronald P Stolk Konstantin Strauch Sian-Tsung Tan Kirill V Tarasov Bosco Trinh Andre G Uitterlinden Malou van den Boogaard Cornelia M van Duijn Wiek H van Gilst Jorma S Viikari Peter M Visscher Veronique Vitart Uwe Völker Melanie Waldenberger Christian X Weichenberger Harm-Jan Westra Cisca Wijmenga Bruce H Wolffenbuttel Jian Yang Connie R Bezzina Patricia B Munroe Harold Snieder Alan F Wright Igor Rudan Laurie A Boyer Folkert W Asselbergs Dirk J van Veldhuisen Bruno H Stricker Bruce M Psaty Marina Ciullo Serena Sanna Terho Lehtimäki James F Wilson Stefania Bandinelli Alvaro Alonso Paolo Gasparini J Wouter Jukema Stefan Kääb Vilmundur Gudnason Stephan B Felix Susan R Heckbert Rudolf A de Boer Christopher Newton-Cheh Andrew A Hicks John C Chambers Yalda Jamshidi Axel Visel Vincent M Christoffels Aaron Isaacs Nilesh J Samani Paul I W de Bakker

J Am Coll Cardiol 2016 09;68(13):1435-1448

Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Epidemiology, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1016/j.jacc.2016.07.729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478167PMC
September 2016

Metaproteomics of saliva identifies human protein markers specific for individuals with periodontitis and dental caries compared to orally healthy controls.

PeerJ 2016 14;4:e2433. Epub 2016 Sep 14.

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.7717/peerj.2433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028799PMC
September 2016

Offline High pH Reversed-Phase Peptide Fractionation for Deep Phosphoproteome Coverage.

Methods Mol Biol 2016 ;1355:179-92

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University ofCopenhagen, Blegdamsvej 3b, 2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/978-1-4939-3049-4_12DOI Listing
August 2016

Simple and Reproducible Sample Preparation for Single-Shot Phosphoproteomics with High Sensitivity.

Methods Mol Biol 2016 ;1355:251-60

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, 2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/978-1-4939-3049-4_17DOI Listing
August 2016

From Phosphosites to Kinases.

Methods Mol Biol 2016 ;1355:307-21

Disease Systems Biology Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, Bldg. 6.2, 2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/978-1-4939-3049-4_21DOI Listing
August 2016

Systems Analysis for Interpretation of Phosphoproteomics Data.

Methods Mol Biol 2016 ;1355:341-60

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, Bldg. 6.1, 2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/978-1-4939-3049-4_23DOI Listing
August 2016

A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase.

Mol Cell 2016 08 21;63(4):686-695. Epub 2016 Jul 21.

Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.06.024DOI Listing
August 2016

Recent findings and technological advances in phosphoproteomics for cells and tissues.

Expert Rev Proteomics 2015 ;12(5):469-87

a Proteomics Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1586/14789450.2015.1078730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819829PMC
June 2016

Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking.

Nat Struct Mol Biol 2016 06 2;23(6):608-18. Epub 2016 May 2.

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/nsmb.3218DOI Listing
June 2016

Analytic framework for peptidomics applied to large-scale neuropeptide identification.

Nat Commun 2016 May 4;7:11436. Epub 2016 May 4.

Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Blegdamsvej 3b, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1038/ncomms11436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857386PMC
May 2016

Disulfide Linkage Characterization of Disulfide Bond-Containing Proteins and Peptides by Reducing Electrochemistry and Mass Spectrometry.

Anal Chem 2016 Feb 8;88(3):1585-92. Epub 2016 Jan 8.

Protein Engineering, Novo Nordisk A/S , Novo Nordisk Park, 2760 Måløv, Denmark.

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http://dx.doi.org/10.1021/acs.analchem.5b03148DOI Listing
February 2016

Protein kinase A stimulates Kv7.1 surface expression by regulating Nedd4-2-dependent endocytic trafficking.

Am J Physiol Cell Physiol 2015 Nov 24;309(10):C693-706. Epub 2015 Sep 24.

The Danish National Research Foundation Center for Cardiac Arrhythmia and The Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark; and

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http://dx.doi.org/10.1152/ajpcell.00383.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652078PMC
November 2015

Comprehensive identification of SUMO2/3 targets and their dynamics during mitosis.

PLoS One 2014 27;9(6):e100692. Epub 2014 Jun 27.

The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100692PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074068PMC
October 2015

Predicting kinase activity in angiotensin receptor phosphoproteomes based on sequence-motifs and interactions.

PLoS One 2014 10;9(4):e94672. Epub 2014 Apr 10.

Department of Clinical Biochemistry, Glostrup Research Institute, Glostrup Hospital, Glostrup, Denmark; Cellular and Metabolic Research Section, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094672PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983226PMC
June 2015

Ubiquitin-specific Protease 11 (USP11) Deubiquitinates Hybrid Small Ubiquitin-like Modifier (SUMO)-Ubiquitin Chains to Counteract RING Finger Protein 4 (RNF4).

J Biol Chem 2015 Jun 12;290(25):15526-37. Epub 2015 May 12.

From the Department of Molecular Cell Biology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands and

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http://dx.doi.org/10.1074/jbc.M114.618132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477612PMC
June 2015

Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation.

Sci Signal 2015 Apr 28;8(374):ra40. Epub 2015 Apr 28.

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1126/scisignal.2005769DOI Listing
April 2015

SILAC-based temporal phosphoproteomics.

Methods Mol Biol 2014 ;1188:125-48

Department of Proteomics, Novo Nordisk Foundation Center for Protein Research, Faculty of Health Science, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/978-1-4939-1142-4_10DOI Listing
March 2015

SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage.

Cell Rep 2015 Mar 12;10(10):1778-1791. Epub 2015 Mar 12.

Department of Molecular Cell Biology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514456PMC
March 2015

Ctk1 function is necessary for full translation initiation activity in Saccharomyces cerevisiae.

Eukaryot Cell 2015 Jan 21;14(1):86-95. Epub 2014 Nov 21.

Gene Center and Department of Biochemistry, Ludwig Maximilians University of Munich, Munich, Germany Center for Integrated Protein Science Munich (CIPSM), Munich, Germany Institute of Biochemistry, Justus Liebig University Gießen, Gießen, Germany

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http://dx.doi.org/10.1128/EC.00106-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279022PMC
January 2015

Ubiquitin-SUMO circuitry controls activated fanconi anemia ID complex dosage in response to DNA damage.

Mol Cell 2015 Jan 31;57(1):150-64. Epub 2014 Dec 31.

Ubiquitin Signaling Group, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765140094
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http://dx.doi.org/10.1016/j.molcel.2014.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416315PMC
January 2015

Off-line high-pH reversed-phase fractionation for in-depth phosphoproteomics.

J Proteome Res 2014 Dec 4;13(12):6176-86. Epub 2014 Nov 4.

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Science, University of Copenhagen , Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/pr500893mDOI Listing
December 2014

Rapid and deep proteomes by faster sequencing on a benchtop quadrupole ultra-high-field Orbitrap mass spectrometer.

J Proteome Res 2014 Dec 10;13(12):6187-95. Epub 2014 Nov 10.

Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen , Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/pr500985wDOI Listing
December 2014

Analysis of changes in SUMO-2/3 modification during breast cancer progression and metastasis.

J Proteome Res 2014 Sep 7;13(9):3905-18. Epub 2014 Aug 7.

Department of Biological Sciences, Wayne State University , 5047 Gullen Mall, Detroit, Michigan 48202, United States.

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http://dx.doi.org/10.1021/pr500119aDOI Listing
September 2014

Analytical utility of mass spectral binning in proteomic experiments by SPectral Immonium Ion Detection (SPIID).

Mol Cell Proteomics 2014 Aug 3;13(8):1914-24. Epub 2014 Jun 3.

From the ‡Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health Sciences, DK-2200 Copenhagen, Denmark;

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http://dx.doi.org/10.1074/mcp.O113.035915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125726PMC
August 2014

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

Authors:
Dan E Arking Sara L Pulit Lia Crotti Pim van der Harst Patricia B Munroe Tamara T Koopmann Nona Sotoodehnia Elizabeth J Rossin Michael Morley Xinchen Wang Andrew D Johnson Alicia Lundby Daníel F Gudbjartsson Peter A Noseworthy Mark Eijgelsheim Yuki Bradford Kirill V Tarasov Marcus Dörr Martina Müller-Nurasyid Annukka M Lahtinen Ilja M Nolte Albert Vernon Smith Joshua C Bis Aaron Isaacs Stephen J Newhouse Daniel S Evans Wendy S Post Daryl Waggott Leo-Pekka Lyytikäinen Andrew A Hicks Lewin Eisele David Ellinghaus Caroline Hayward Pau Navarro Sheila Ulivi Toshiko Tanaka David J Tester Stéphanie Chatel Stefan Gustafsson Meena Kumari Richard W Morris Åsa T Naluai Sandosh Padmanabhan Alexander Kluttig Bernhard Strohmer Andrie G Panayiotou Maria Torres Michael Knoflach Jaroslav A Hubacek Kamil Slowikowski Soumya Raychaudhuri Runjun D Kumar Tamara B Harris Lenore J Launer Alan R Shuldiner Alvaro Alonso Joel S Bader Georg Ehret Hailiang Huang W H Linda Kao James B Strait Peter W Macfarlane Morris Brown Mark J Caulfield Nilesh J Samani Florian Kronenberg Johann Willeit J Gustav Smith Karin H Greiser Henriette Meyer Zu Schwabedissen Karl Werdan Massimo Carella Leopoldo Zelante Susan R Heckbert Bruce M Psaty Jerome I Rotter Ivana Kolcic Ozren Polašek Alan F Wright Maura Griffin Mark J Daly David O Arnar Hilma Hólm Unnur Thorsteinsdottir Joshua C Denny Dan M Roden Rebecca L Zuvich Valur Emilsson Andrew S Plump Martin G Larson Christopher J O'Donnell Xiaoyan Yin Marco Bobbo Adamo P D'Adamo Annamaria Iorio Gianfranco Sinagra Angel Carracedo Steven R Cummings Michael A Nalls Antti Jula Kimmo K Kontula Annukka Marjamaa Lasse Oikarinen Markus Perola Kimmo Porthan Raimund Erbel Per Hoffmann Karl-Heinz Jöckel Hagen Kälsch Markus M Nöthen Marcel den Hoed Ruth J F Loos Dag S Thelle Christian Gieger Thomas Meitinger Siegfried Perz Annette Peters Hanna Prucha Moritz F Sinner Melanie Waldenberger Rudolf A de Boer Lude Franke Pieter A van der Vleuten Britt Maria Beckmann Eimo Martens Abdennasser Bardai Nynke Hofman Arthur A M Wilde Elijah R Behr Chrysoula Dalageorgou John R Giudicessi Argelia Medeiros-Domingo Julien Barc Florence Kyndt Vincent Probst Alice Ghidoni Roberto Insolia Robert M Hamilton Stephen W Scherer Jeffrey Brandimarto Kenneth Margulies Christine E Moravec Fabiola del Greco M Christian Fuchsberger Jeffrey R O'Connell Wai K Lee Graham C M Watt Harry Campbell Sarah H Wild Nour E El Mokhtari Norbert Frey Folkert W Asselbergs Irene Mateo Leach Gerjan Navis Maarten P van den Berg Dirk J van Veldhuisen Manolis Kellis Bouwe P Krijthe Oscar H Franco Albert Hofman Jan A Kors André G Uitterlinden Jacqueline C M Witteman Lyudmyla Kedenko Claudia Lamina Ben A Oostra Gonçalo R Abecasis Edward G Lakatta Antonella Mulas Marco Orrú David Schlessinger Manuela Uda Marcello R P Markus Uwe Völker Harold Snieder Timothy D Spector Johan Ärnlöv Lars Lind Johan Sundström Ann-Christine Syvänen Mika Kivimaki Mika Kähönen Nina Mononen Olli T Raitakari Jorma S Viikari Vera Adamkova Stefan Kiechl Maria Brion Andrew N Nicolaides Bernhard Paulweber Johannes Haerting Anna F Dominiczak Fredrik Nyberg Peter H Whincup Aroon D Hingorani Jean-Jacques Schott Connie R Bezzina Erik Ingelsson Luigi Ferrucci Paolo Gasparini James F Wilson Igor Rudan Andre Franke Thomas W Mühleisen Peter P Pramstaller Terho J Lehtimäki Andrew D Paterson Afshin Parsa Yongmei Liu Cornelia M van Duijn David S Siscovick Vilmundur Gudnason Yalda Jamshidi Veikko Salomaa Stephan B Felix Serena Sanna Marylyn D Ritchie Bruno H Stricker Kari Stefansson Laurie A Boyer Thomas P Cappola Jesper V Olsen Kasper Lage Peter J Schwartz Stefan Kääb Aravinda Chakravarti Michael J Ackerman Arne Pfeufer Paul I W de Bakker Christopher Newton-Cheh

Nat Genet 2014 Aug 22;46(8):826-36. Epub 2014 Jun 22.

1] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts, USA. [4] Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA. [5].

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August 2014

PRIME-XS, a European infrastructure for proteomics.

Mol Cell Proteomics 2014 Aug 23;13(8):1901-4. Epub 2014 Jun 23.

From the *Biomolecular Mass Spectrometry and Proteomics Group, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, Utrecht, 3584 CH, The Netherlands;

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August 2014

A direct role of Mad1 in the spindle assembly checkpoint beyond Mad2 kinetochore recruitment.

EMBO Rep 2014 Mar 29;15(3):282-90. Epub 2014 Jan 29.

The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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March 2014

Uncovering SUMOylation dynamics during cell-cycle progression reveals FoxM1 as a key mitotic SUMO target protein.

Mol Cell 2014 Mar 27;53(6):1053-66. Epub 2014 Feb 27.

Department of Molecular Cell Biology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands. Electronic address:

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March 2014

Status of large-scale analysis of post-translational modifications by mass spectrometry.

Mol Cell Proteomics 2013 Dec 1;12(12):3444-52. Epub 2013 Nov 1.

Department of Proteomics, Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Blegdamsvej 3b, DK-2200 Copenhagen, Denmark;

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December 2013

TIMP-1 increases expression and phosphorylation of proteins associated with drug resistance in breast cancer cells.

J Proteome Res 2013 Sep 21;12(9):4136-51. Epub 2013 Aug 21.

Institute of Veterinary Disease Biology, Faculty of Health and Medical Sciences and Sino-Danish Breast Cancer Research Centre, University of Copenhagen, Dyrlægevej 88, 1., 1870 Frederiksberg C, Denmark.

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September 2013

Phosphoproteomics taken to heart.

Cell Cycle 2013 Sep 6;12(17):2707-8. Epub 2013 Aug 6.

Novo Nordisk Foundation Center for Protein Research; Department for Proteomics; Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen, Denmark; The Danish National Research Foundation Centre for Cardiac Arrhythmia; Copenhagen, Denmark.

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September 2013

Functional proteomics defines the molecular switch underlying FGF receptor trafficking and cellular outputs.

Mol Cell 2013 Sep 5;51(6):707-22. Epub 2013 Sep 5.

Department of Proteomics, NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.

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September 2013

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.

Authors:
Marcel den Hoed Mark Eijgelsheim Tõnu Esko Bianca J J M Brundel David S Peal David M Evans Ilja M Nolte Ayellet V Segrè Hilma Holm Robert E Handsaker Harm-Jan Westra Toby Johnson Aaron Isaacs Jian Yang Alicia Lundby Jing Hua Zhao Young Jin Kim Min Jin Go Peter Almgren Murielle Bochud Gabrielle Boucher Marilyn C Cornelis Daniel Gudbjartsson David Hadley Pim van der Harst Caroline Hayward Martin den Heijer Wilmar Igl Anne U Jackson Zoltán Kutalik Jian'an Luan John P Kemp Kati Kristiansson Claes Ladenvall Mattias Lorentzon May E Montasser Omer T Njajou Paul F O'Reilly Sandosh Padmanabhan Beate St Pourcain Tuomo Rankinen Perttu Salo Toshiko Tanaka Nicholas J Timpson Veronique Vitart Lindsay Waite William Wheeler Weihua Zhang Harmen H M Draisma Mary F Feitosa Kathleen F Kerr Penelope A Lind Evelin Mihailov N Charlotte Onland-Moret Ci Song Michael N Weedon Weijia Xie Loic Yengo Devin Absher Christine M Albert Alvaro Alonso Dan E Arking Paul I W de Bakker Beverley Balkau Cristina Barlassina Paola Benaglio Joshua C Bis Nabila Bouatia-Naji Søren Brage Stephen J Chanock Peter S Chines Mina Chung Dawood Darbar Christian Dina Marcus Dörr Paul Elliott Stephan B Felix Krista Fischer Christian Fuchsberger Eco J C de Geus Philippe Goyette Vilmundur Gudnason Tamara B Harris Anna-Liisa Hartikainen Aki S Havulinna Susan R Heckbert Andrew A Hicks Albert Hofman Suzanne Holewijn Femke Hoogstra-Berends Jouke-Jan Hottenga Majken K Jensen Asa Johansson Juhani Junttila Stefan Kääb Bart Kanon Shamika Ketkar Kay-Tee Khaw Joshua W Knowles Angrad S Kooner Jan A Kors Meena Kumari Lili Milani Päivi Laiho Edward G Lakatta Claudia Langenberg Maarten Leusink Yongmei Liu Robert N Luben Kathryn L Lunetta Stacey N Lynch Marcello R P Markus Pedro Marques-Vidal Irene Mateo Leach Wendy L McArdle Steven A McCarroll Sarah E Medland Kathryn A Miller Grant W Montgomery Alanna C Morrison Martina Müller-Nurasyid Pau Navarro Mari Nelis Jeffrey R O'Connell Christopher J O'Donnell Ken K Ong Anne B Newman Annette Peters Ozren Polasek Anneli Pouta Peter P Pramstaller Bruce M Psaty Dabeeru C Rao Susan M Ring Elizabeth J Rossin Diana Rudan Serena Sanna Robert A Scott Jaban S Sehmi Stephen Sharp Jordan T Shin Andrew B Singleton Albert V Smith Nicole Soranzo Tim D Spector Chip Stewart Heather M Stringham Kirill V Tarasov André G Uitterlinden Liesbeth Vandenput Shih-Jen Hwang John B Whitfield Cisca Wijmenga Sarah H Wild Gonneke Willemsen James F Wilson Jacqueline C M Witteman Andrew Wong Quenna Wong Yalda Jamshidi Paavo Zitting Jolanda M A Boer Dorret I Boomsma Ingrid B Borecki Cornelia M van Duijn Ulf Ekelund Nita G Forouhi Philippe Froguel Aroon Hingorani Erik Ingelsson Mika Kivimaki Richard A Kronmal Diana Kuh Lars Lind Nicholas G Martin Ben A Oostra Nancy L Pedersen Thomas Quertermous Jerome I Rotter Yvonne T van der Schouw W M Monique Verschuren Mark Walker Demetrius Albanes David O Arnar Themistocles L Assimes Stefania Bandinelli Michael Boehnke Rudolf A de Boer Claude Bouchard W L Mark Caulfield John C Chambers Gary Curhan Daniele Cusi Johan Eriksson Luigi Ferrucci Wiek H van Gilst Nicola Glorioso Jacqueline de Graaf Leif Groop Ulf Gyllensten Wen-Chi Hsueh Frank B Hu Heikki V Huikuri David J Hunter Carlos Iribarren Bo Isomaa Marjo-Riitta Jarvelin Antti Jula Mika Kähönen Lambertus A Kiemeney Melanie M van der Klauw Jaspal S Kooner Peter Kraft Licia Iacoviello Terho Lehtimäki Marja-Liisa L Lokki Braxton D Mitchell Gerjan Navis Markku S Nieminen Claes Ohlsson Neil R Poulter Lu Qi Olli T Raitakari Eric B Rimm John D Rioux Federica Rizzi Igor Rudan Veikko Salomaa Peter S Sever Denis C Shields Alan R Shuldiner Juha Sinisalo Alice V Stanton Ronald P Stolk David P Strachan Jean-Claude Tardif Unnur Thorsteinsdottir Jaako Tuomilehto Dirk J van Veldhuisen Jarmo Virtamo Jorma Viikari Peter Vollenweider Gérard Waeber Elisabeth Widen Yoon Shin Cho Jesper V Olsen Peter M Visscher Cristen Willer Lude Franke Jeanette Erdmann John R Thompson Arne Pfeufer Nona Sotoodehnia Christopher Newton-Cheh Patrick T Ellinor Bruno H Ch Stricker Andres Metspalu Markus Perola Jacques S Beckmann George Davey Smith Kari Stefansson Nicholas J Wareham Patricia B Munroe Ody C M Sibon David J Milan Harold Snieder Nilesh J Samani Ruth J F Loos

Nat Genet 2013 Jun 14;45(6):621-31. Epub 2013 Apr 14.

Medical Research Council MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

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June 2013

Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition.

Structure 2013 Jun 9;21(6):986-96. Epub 2013 May 9.

Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, UK.

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June 2013

In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling.

Sci Signal 2013 Jun 4;6(278):rs11. Epub 2013 Jun 4.

Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, DK-2200 Copenhagen, Denmark.

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June 2013

Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells.

Sci Signal 2013 Jan 22;6(259):ra5. Epub 2013 Jan 22.

Division of Toxicology, Leiden/Amsterdam Center for Drug Research, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands.

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January 2013

Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.

Mol Cell Proteomics 2012 Dec 11;11(12):1578-85. Epub 2012 Jul 11.

Department of Proteomics, The NNF Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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December 2012

A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin.

Endocrinology 2012 Dec 12;153(12):5782-95. Epub 2012 Oct 12.

Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, 2200 Denmark.

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Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.

Cell Rep 2012 Aug 16;2(2):419-31. Epub 2012 Aug 16.

Novo Nordisk Foundation Center for Protein Research, Department for Proteomics, Faculty of Health Sciences, University of Copenhagen, Denmark.

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August 2012

The Ndc80 internal loop is required for recruitment of the Ska complex to establish end-on microtubule attachment to kinetochores.

J Cell Sci 2012 Jul 27;125(Pt 13):3243-53. Epub 2012 Mar 27.

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Optimized fast and sensitive acquisition methods for shotgun proteomics on a quadrupole orbitrap mass spectrometer.

J Proteome Res 2012 Jun 10;11(6):3487-97. Epub 2012 May 10.

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Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

Nat Commun 2012 Jun 6;3:876. Epub 2012 Jun 6.

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June 2012

Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.

Mol Cell 2012 Apr 15;46(2):212-25. Epub 2012 Mar 15.

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April 2012

Proteomic analysis of a pleistocene mammoth femur reveals more than one hundred ancient bone proteins.

J Proteome Res 2012 Feb 14;11(2):917-26. Epub 2011 Dec 14.

Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen , Øster Voldgade 5-7, 1350, Copenhagen, Denmark.

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February 2012

Pre-Clovis mastodon hunting 13,800 years ago at the Manis site, Washington.

Science 2011 Oct;334(6054):351-3

Center for the Study of the First Americans, Department of Anthropology, Texas A&M University, 4352 TAMU, College Station, TX 77843-4352, USA.

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October 2011

GeLCMS for in-depth protein characterization and advanced analysis of proteomes.

Methods Mol Biol 2011 ;753:143-55

Faculty of Health Sciences, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, DK-2200, Denmark.

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September 2011

Pinpointing phosphorylation sites: Quantitative filtering and a novel site-specific x-ion fragment.

J Proteome Res 2011 Jul 28;10(7):2937-48. Epub 2011 Apr 28.

Department for Proteomics, NNF Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3b, DK-2200 Copenhagen, Denmark.

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July 2011

Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.

Sci Signal 2011 Jul 26;4(183):ra48. Epub 2011 Jul 26.

Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark.

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July 2011

Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase.

Genes Dev 2011 Jun 6;25(12):1232-44. Epub 2011 Jun 6.

Department of Cell Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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June 2011

Phosphorylation of the yeast γ-tubulin Tub4 regulates microtubule function.

PLoS One 2011 May 5;6(5):e19700. Epub 2011 May 5.

Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Allianz, Heidelberg, Germany.

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May 2011

Andromeda: a peptide search engine integrated into the MaxQuant environment.

J Proteome Res 2011 Apr 22;10(4):1794-805. Epub 2011 Feb 22.

Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.

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April 2011

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

Sci Signal 2011 Mar 15;4(164):rs3. Epub 2011 Mar 15.

Center for Experimental BioInformatics, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.

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March 2011

Effective representation and storage of mass spectrometry-based proteomic data sets for the scientific community.

Sci Signal 2011 Feb 15;4(160):pe7. Epub 2011 Feb 15.

Center for Protein Research, University of Copenhagen, Faculty of Health Sciences, Blegdamsvej 3b, DK-2200 Copenhagen N, Denmark.

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February 2011