Publications by authors named "Jesper Q Svejstrup"

86Publications

Multiplex Cell Fate Tracking by Flow Cytometry.

Methods Protoc 2020 Jul 17;3(3). Epub 2020 Jul 17.

Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

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http://dx.doi.org/10.3390/mps3030050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565161PMC
July 2020

The ASC-1 Complex Disassembles Collided Ribosomes.

Mol Cell 2020 08 23;79(4):603-614.e8. Epub 2020 Jun 23.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447978PMC
August 2020

Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver.

Cell 2020 Jun;181(6):1395-1405.e11

Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298618PMC
June 2020

Using TT-seq for profiling nascent transcription and measuring transcript elongation.

Nat Protoc 2020 02 8;15(2):604-627. Epub 2020 Jan 8.

Mechanisms of Transcription Laboratory, The Francis Crick Institute, London, UK.

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http://dx.doi.org/10.1038/s41596-019-0262-3DOI Listing
February 2020

Watch Out for Those Terrible Twos! Dinucleotide Accumulation Dysregulates Mitochondrial Transcription.

Mol Cell 2019 12;76(5):696-698

Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.11.002DOI Listing
December 2019

Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability.

Mol Cell 2019 10 10;76(1):57-69.e9. Epub 2019 Sep 10.

Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.07.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863433PMC
October 2019

A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin.

Structure 2019 08 13;27(8):1316-1325.e6. Epub 2019 Jun 13.

Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.str.2019.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688830PMC
August 2019

SCAF4 and SCAF8, mRNA Anti-Terminator Proteins.

Cell 2019 06 16;177(7):1797-1813.e18. Epub 2019 May 16.

Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.04.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579486PMC
June 2019

Genome-wide reconstitution of chromatin transactions reveals that RSC preferentially disrupts H2AZ-containing nucleosomes.

Genome Res 2019 06 16;29(6):988-998. Epub 2019 May 16.

Mechanisms of Transcription Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom.

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http://dx.doi.org/10.1101/gr.243139.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581049PMC
June 2019

Analysis of RNA polymerase II ubiquitylation and proteasomal degradation.

Methods 2019 04 13;159-160:146-156. Epub 2019 Feb 13.

Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2019.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617506PMC
April 2019

The Cellular Response to Transcription-Blocking DNA Damage.

Trends Biochem Sci 2018 05;43(5):327-341

Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2018.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929563PMC
May 2018

UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene.

Cell 2017 02 16;168(5):843-855.e13. Epub 2017 Feb 16.

Mechanisms of Transcription Laboratory, The Francis Crick Institute, Clare Hall Laboratories, South Mimms EN6 3LD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332558PMC
February 2017

Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation.

Cell Rep 2016 Mar 10;14(11):2554-61. Epub 2016 Mar 10.

Mechanisms of Transcription Laboratory, Clare Hall Laboratories, The Francis Crick Institute, South Mimms, Hertfordshire EN6 3LD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.02.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806223PMC
March 2016

Retention of the Native Epigenome in Purified Mammalian Chromatin.

PLoS One 2015 6;10(8):e0133246. Epub 2015 Aug 6.

Mechanisms of Transcription Laboratory, Clare Hall Laboratories, The Francis Crick Insitute, London Research Institute, South Mimms, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133246PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527833PMC
May 2016

Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease.

Proc Natl Acad Sci U S A 2014 Oct 23;111(40):14454-9. Epub 2014 Sep 23.

Mechanisms of Transcription Laboratory, Cancer Research UK London Research Institute, South Mimms EN6 3LD, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1412569111
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http://dx.doi.org/10.1073/pnas.1412569111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210037PMC
October 2014

RECQL5 controls transcript elongation and suppresses genome instability associated with transcription stress.

Cell 2014 May 15;157(5):1037-49. Epub 2014 May 15.

Mechanisms of Transcription Laboratory, Clare Hall Laboratories, Cancer Research UK London Research Institute, South Mimms, EN6 3LD, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674140047
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http://dx.doi.org/10.1016/j.cell.2014.03.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032574PMC
May 2014

Proteasome-mediated processing of Def1, a critical step in the cellular response to transcription stress.

Cell 2013 Aug;154(5):983-995

Mechanisms of Transcription Laboratory, Clare Hall Laboratories, Cancer Research UK London Research Institute, South Mimms EN6 3LD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2013.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778974PMC
August 2013

Synovial sarcoma mechanisms: a series of unfortunate events.

Cell 2013 Mar;153(1):11-2

Cancer Research UK, London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, UK.

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http://dx.doi.org/10.1016/j.cell.2013.03.015DOI Listing
March 2013

RNA polymerase II transcript elongation.

Biochim Biophys Acta 2013 Jan;1829(1)

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http://dx.doi.org/10.1016/j.bbagrm.2012.12.008DOI Listing
January 2013

MultiDsk: a ubiquitin-specific affinity resin.

PLoS One 2012 3;7(10):e46398. Epub 2012 Oct 3.

Mechanisms of Transcription Laboratory, Clare Hall Laboratories, Cancer Research UK London Research Institute, Potters Bar, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046398PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463603PMC
June 2013

RNA polymerase II collision interrupts convergent transcription.

Mol Cell 2012 Nov 4;48(3):365-74. Epub 2012 Oct 4.

Mechanisms of Transcription Laboratory, Clare Hall Laboratories, Cancer Research UK London Research Institute, South Mimms, London EN6 3LD, UK.

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http://www.cell.com/molecular-cell/pdf/S1097-2765(12)00770-8
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http://linkinghub.elsevier.com/retrieve/pii/S109727651200770
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http://dx.doi.org/10.1016/j.molcel.2012.08.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504299PMC
November 2012

Ubiquitylation and degradation of elongating RNA polymerase II: the last resort.

Biochim Biophys Acta 2013 Jan 31;1829(1):151-7. Epub 2012 Aug 31.

Mechanisms of Transcription Laboratory, Cancer Research UK London Research Institute, South Mimms, UK.

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http://dx.doi.org/10.1016/j.bbagrm.2012.08.002DOI Listing
January 2013

Transcription: another mark in the tail.

EMBO J 2012 Jun 22;31(12):2753-4. Epub 2012 May 22.

Mechanisms of Transcription Laboratory, Cancer Research UK London Research Institute, South Mimms, UK.

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http://emboj.embopress.org/cgi/doi/10.1038/emboj.2012.154
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http://dx.doi.org/10.1038/emboj.2012.154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380221PMC
June 2012

DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.

Nature 2012 Mar 25;484(7394):386-9. Epub 2012 Mar 25.

Mechanisms of Transcription Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms EN6 3LD, UK.

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http://www.nature.com/doifinder/10.1038/nature10925
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http://dx.doi.org/10.1038/nature10925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378035PMC
March 2012

Studying RNA-protein interactions in vivo by RNA immunoprecipitation.

Methods Mol Biol 2011 ;791:253-64

Dame Roma Mitchell Cancer Research Laboratories, The University of Adelaide, Adelaide, SA, Australia.

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http://link.springer.com/10.1007/978-1-61779-316-5_19
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http://dx.doi.org/10.1007/978-1-61779-316-5_19DOI Listing
December 2011

GTP-dependent binding and nuclear transport of RNA polymerase II by Npa3 protein.

J Biol Chem 2011 Oct 15;286(41):35553-61. Epub 2011 Aug 15.

Mechanisms of Transcription Laboratory, Clare Hall Laboratories, Cancer Research UK London Research Institute, South Mimms EN6 3LD, UK.

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http://dx.doi.org/10.1074/jbc.M111.286161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195585PMC
October 2011

Role of elongator subunit Elp3 in Drosophila melanogaster larval development and immunity.

Genetics 2011 Apr 1;187(4):1067-75. Epub 2011 Feb 1.

Clare Hall Laboratories, Cancer Research UK London Research Institute, South Mimms EN6 3LD, United Kingdom.

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http://dx.doi.org/10.1534/genetics.110.123893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070516PMC
April 2011

Transcript Elongation by RNA Polymerase II.

Annu Rev Biochem 2010 ;79:271-93

Mechanisms of Transcription Laboratory, Clare Hall Laboratories, Cancer Research UK London Research Institute, South Mimms, Hertfordshire EN6 3LD, United Kingdom.

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http://www.annualreviews.org/doi/10.1146/annurev.biochem.78.
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http://dx.doi.org/10.1146/annurev.biochem.78.062807.091425DOI Listing
June 2010

The interface between transcription and mechanisms maintaining genome integrity.

Trends Biochem Sci 2010 Jun 1;35(6):333-8. Epub 2010 Mar 1.

Clare Hall Laboratories, Cancer Research UK London Research Institute, Blanche Lane, South Mimms, EN6 3LD, UK.

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http://dx.doi.org/10.1016/j.tibs.2010.02.001DOI Listing
June 2010

RNA immunoprecipitation to determine RNA-protein associations in vivo.

Cold Spring Harb Protoc 2009 Jun;2009(6):pdb.prot5234

Mechanisms of Gene Transcription Laboratory, Cancer Research UK London Research Institute, South Mimms, Hertfordshire EN6 3LD, UK.

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http://dx.doi.org/10.1101/pdb.prot5234DOI Listing
June 2009

RECQL5 helicase: connections to DNA recombination and RNA polymerase II transcription.

DNA Repair (Amst) 2010 Mar 18;9(3):345-53. Epub 2010 Jan 18.

Mechanisms of Transcription Laboratory, Clare Hall Laboratories, Cancer Research UK London Research Institute, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, United Kingdom.

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http://dx.doi.org/10.1016/j.dnarep.2009.12.008DOI Listing
March 2010

Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation.

Proc Natl Acad Sci U S A 2009 Dec 17;106(49):20705-10. Epub 2009 Nov 17.

Mechanisms of Transcription Laboratory, Clare Hall Laboratories, Cancer Research UK London Research Institute, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0907052106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778569PMC
December 2009

A role for checkpoint kinase-dependent Rad26 phosphorylation in transcription-coupled DNA repair in Saccharomyces cerevisiae.

Mol Cell Biol 2010 Jan 9;30(2):436-46. Epub 2009 Nov 9.

Clare Hall Laboratories, Cancer Research UK London Research Institute, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, United Kingdom.

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http://dx.doi.org/10.1128/MCB.00822-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798469PMC
January 2010

Interacting partners of the Tfb2 subunit from yeast TFIIH.

DNA Repair (Amst) 2010 Jan 7;9(1):33-9. Epub 2009 Nov 7.

Institute for Molecular Medicine Finland, University of Helsinki, Finland.

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http://dx.doi.org/10.1016/j.dnarep.2009.10.002DOI Listing
January 2010

Stability, flexibility, and dynamic interactions of colliding RNA polymerase II elongation complexes.

Mol Cell 2009 Jul;35(2):191-205

Mechanisms of Transcription Laboratory, Clare Hall Laboratories, Cancer Research UK London Research Institute, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S109727650900400
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http://dx.doi.org/10.1016/j.molcel.2009.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791892PMC
July 2009

Direct inhibition of RNA polymerase II transcription by RECQL5.

J Biol Chem 2009 Aug 1;284(35):23197-203. Epub 2009 Jul 1.

Mechanisms of Transcription Laboratory, Clare Hall Laboratories, Cancer Research UK, London Research Institute, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.015750
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http://dx.doi.org/10.1074/jbc.M109.015750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749093PMC
August 2009

An rtt109-independent role for vps75 in transcription-associated nucleosome dynamics.

Mol Cell Biol 2009 Aug 26;29(15):4220-34. Epub 2009 May 26.

Clare Hall Laboratories, Cancer Research UK London Research Institute, Blanche Lane, South Mimms, Hertfordshire, U.K.

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http://dx.doi.org/10.1128/MCB.01882-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715805PMC
August 2009

An iron-sulfur cluster domain in Elp3 important for the structural integrity of elongator.

J Biol Chem 2009 Jan 5;284(1):141-9. Epub 2008 Nov 5.

Clare Hall Laboratories, Cancer Research UK London Research Institute, Blanche Lane, South Mimms EN6 3LD, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M805312200
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http://dx.doi.org/10.1074/jbc.M805312200DOI Listing
January 2009

Reversal of RNA polymerase II ubiquitylation by the ubiquitin protease Ubp3.

Mol Cell 2008 May;30(4):498-506

Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Herts EN6 3LD, UK.

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http://dx.doi.org/10.1016/j.molcel.2008.04.018DOI Listing
May 2008

RNA immunoprecipitation for determining RNA-protein associations in vivo.

Curr Protoc Mol Biol 2006 Aug;Chapter 27:Unit 27.4

Cancer Research UK, London Research Institute, Clare Hall Laboratories, Hertfordshire, UK.

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http://dx.doi.org/10.1002/0471142727.mb2704s75DOI Listing
August 2006

Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.

Mol Cell 2007 Nov;28(3):386-97

Clare Hall Laboratories, Cancer Research UK London Research Institute, Blanche Lane, South Mimms EN6 3LD, UK.

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http://dx.doi.org/10.1016/j.molcel.2007.10.008DOI Listing
November 2007

A role for noncoding transcription in activation of the yeast PHO5 gene.

Proc Natl Acad Sci U S A 2007 May 30;104(19):8011-6. Epub 2007 Apr 30.

Mechanisms of Transcription Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms EN6 3LD, United Kingdom.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0702431104
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http://dx.doi.org/10.1073/pnas.0702431104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1859995PMC
May 2007

Elongator complex: how many roles does it play?

Curr Opin Cell Biol 2007 Jun 26;19(3):331-6. Epub 2007 Apr 26.

Clare Hall Laboratories, Cancer Research UK London Research Institute, Blanche Lane, South Mimms, EN6 3LD, UK.

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http://dx.doi.org/10.1016/j.ceb.2007.04.005DOI Listing
June 2007

Communication between distant sites in RNA polymerase II through ubiquitylation factors and the polymerase CTD.

Cell 2007 Apr;129(1):57-68

Mechanisms of Transcription Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, UK.

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http://dx.doi.org/10.1016/j.cell.2007.01.046DOI Listing
April 2007

Hyperphosphorylation of the C-terminal repeat domain of RNA polymerase II facilitates dissociation of its complex with mediator.

J Biol Chem 2007 May 21;282(19):14113-20. Epub 2007 Mar 21.

Clare Hall Laboratories, Cancer Research UK London Research Institute, Blanche Lane, South Mimms, UK.

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http://dx.doi.org/10.1074/jbc.M701345200DOI Listing
May 2007

Contending with transcriptional arrest during RNAPII transcript elongation.

Trends Biochem Sci 2007 Apr 8;32(4):165-71. Epub 2007 Mar 8.

Clare Hall Laboratories, Cancer Research UK London Research Institute, South Mimms, London EN6 3LD, UK.

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http://dx.doi.org/10.1016/j.tibs.2007.02.005DOI Listing
April 2007

Vps75, a new yeast member of the NAP histone chaperone family.

J Biol Chem 2007 Apr 7;282(17):12358-62. Epub 2007 Mar 7.

Clare Hall Laboratories, Cancer Research UK London Research Institute, Blanche Lane, South Mimms, EN6 3LD, United Kingdom.

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http://dx.doi.org/10.1074/jbc.C700012200DOI Listing
April 2007

RNA polymerase II: a "nobel" enzyme demystified.

Mol Cell 2006 Dec;24(5):637-642

Stowers Institute for Medical Research, Kansas City, Missouri 64112. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2006.11.016DOI Listing
December 2006

An assay for studying ubiquitylation of RNA polymerase II and other proteins in crude yeast extracts.

Methods Enzymol 2006 ;408:264-73

Cancer Research United Kingdom, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire.

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http://dx.doi.org/10.1016/S0076-6879(06)08016-5DOI Listing
February 2007

Multiple mechanisms confining RNA polymerase II ubiquitylation to polymerases undergoing transcriptional arrest.

Cell 2005 Jun;121(6):913-23

Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Herts EN6 3LD, United Kingdom.

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http://dx.doi.org/10.1016/j.cell.2005.04.010DOI Listing
June 2005

Physical and functional interaction between Elongator and the chromatin-associated Kti12 protein.

J Biol Chem 2005 May 16;280(20):19454-60. Epub 2005 Mar 16.

Cancer Research UK London Research Institute, Clare Hall Laboratories, Hertfordshire, UK.

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http://dx.doi.org/10.1074/jbc.M413373200DOI Listing
May 2005

Interaction of Fcp1 phosphatase with elongating RNA polymerase II holoenzyme, enzymatic mechanism of action, and genetic interaction with elongator.

J Biol Chem 2005 Feb 24;280(6):4299-306. Epub 2004 Nov 24.

Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, EN6 3LD, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M411071200DOI Listing
February 2005

Evidence for distinct mechanisms facilitating transcript elongation through chromatin in vivo.

EMBO J 2004 Oct 30;23(21):4243-52. Epub 2004 Sep 30.

Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.

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http://emboj.embopress.org/cgi/doi/10.1038/sj.emboj.7600433
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http://dx.doi.org/10.1038/sj.emboj.7600433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC524397PMC
October 2004

DNA damage-induced Def1-RNA polymerase II interaction and Def1 requirement for polymerase ubiquitylation in vitro.

J Biol Chem 2004 Jul 27;279(29):29875-8. Epub 2004 May 27.

Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, United Kingdom.

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http://dx.doi.org/10.1074/jbc.C400185200DOI Listing
July 2004

Elongator interactions with nascent mRNA revealed by RNA immunoprecipitation.

Mol Cell 2004 May;14(4):457-64

Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, United Kingdom.

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http://dx.doi.org/10.1016/s1097-2765(04)00239-4DOI Listing
May 2004

Molecular architecture, structure-function relationship, and importance of the Elp3 subunit for the RNA binding of holo-elongator.

J Biol Chem 2004 Jul 11;279(31):32087-92. Epub 2004 May 11.

Cancer Research UK, London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M403361200
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http://dx.doi.org/10.1074/jbc.M403361200DOI Listing
July 2004

The RNA polymerase II transcription cycle: cycling through chromatin.

Biochim Biophys Acta 2004 Mar;1677(1-3):64-73

Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire, EN6 3LD, UK.

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http://dx.doi.org/10.1016/j.bbaexp.2003.10.012DOI Listing
March 2004

Purification of elongating RNA polymerase II and other factors from yeast chromatin.

Methods Enzymol 2003 ;371:491-8

London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S007668790371036
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http://dx.doi.org/10.1016/S0076-6879(03)71036-2DOI Listing
February 2004

Transcription. Histones face the FACT.

Science 2003 Aug;301(5636):1053-5

Cancer Research, London Research Institute, Clare Hall Laboratories, Hertfordshire, UK.

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http://dx.doi.org/10.1126/science.1088901DOI Listing
August 2003

Spreading of Sir3 protein in cells with severe histone H3 hypoacetylation.

Proc Natl Acad Sci U S A 2003 Jun 9;100(13):7551-6. Epub 2003 Jun 9.

Mechanisms of Transcription Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1332299100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164624PMC
June 2003

Incision of a 1,3-intrastrand d(GpTpG)-cisplatin adduct by nucleotide excision repair proteins from yeast.

DNA Repair (Amst) 2002 Sep;1(9):731-41

Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire, UK.

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http://dx.doi.org/10.1016/s1568-7864(02)00080-0DOI Listing
September 2002

Rescue of arrested RNA polymerase II complexes.

J Cell Sci 2003 Feb;116(Pt 3):447-51

Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.

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http://dx.doi.org/10.1242/jcs.00271DOI Listing
February 2003

The NC2 alpha and beta subunits play different roles in vivo.

Genes Dev 2002 Dec;16(24):3265-76

Department Biochimie Médicale, CMU, Geneva 4, Switzerland.

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http://dx.doi.org/10.1101/gad.234002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC187505PMC
December 2002

Transcriptional inhibition of genes with severe histone h3 hypoacetylation in the coding region.

Mol Cell 2002 Oct;10(4):925-33

Mechanisms of Transcription Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, EN6 3LD, Hertfordshire, United Kingdom.

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http://dx.doi.org/10.1016/s1097-2765(02)00647-0DOI Listing
October 2002

Transcription repair coupling factor: a very pushy enzyme.

Mol Cell 2002 Jun;9(6):1151-2

Cancer Research UK London Research Institute, Clare Hall Laboratory, South Mimms, EN6 3LD, UK.

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http://dx.doi.org/10.1016/s1097-2765(02)00553-1DOI Listing
June 2002

Isolation and mass spectrometry of transcription factor complexes.

Methods 2002 Mar;26(3):260-9

Cancer Research UK London Research Institute, Clare Hall Laboratories, Blanche Lane, South Mimms, EN6 3LD, Hertfordshire, UK.

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http://dx.doi.org/10.1016/S1046-2023(02)00030-0DOI Listing
March 2002

Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo.

Proc Natl Acad Sci U S A 2002 Mar;99(6):3517-22

Cancer Research UK., London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, United Kingdom.

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http://dx.doi.org/10.1073/pnas.022042899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122555PMC
March 2002

Chromatin elongation factors.

Curr Opin Genet Dev 2002 Apr;12(2):156-61

Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.

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http://dx.doi.org/10.1016/s0959-437x(02)00281-2DOI Listing
April 2002

A Rad26-Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damage.

Nature 2002 Feb;415(6874):929-33

Mechanisms of Gene Transcription Laboratory, Cancer Research UK, Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, UK.

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http://www.nature.com/articles/415929a
Publisher Site
http://dx.doi.org/10.1038/415929aDOI Listing
February 2002

Mechanisms of transcription-coupled DNA repair.

Nat Rev Mol Cell Biol 2002 Jan;3(1):21-9

Imperial Cancer Research Fund, Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, UK.

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http://www.nature.com/articles/nrm703
Publisher Site
http://dx.doi.org/10.1038/nrm703DOI Listing
January 2002

Purification and characterization of the human elongator complex.

J Biol Chem 2002 Jan 19;277(4):3047-52. Epub 2001 Nov 19.

Mechanisms of Gene Transcription Laboratory, Imperial Cancer Research Fund Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire, EN6 3LD, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110445200DOI Listing
January 2002