Jesper Olsen

Jesper Olsen

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Jesper Olsen

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Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites.

Cell 2019 Oct;179(2):543-560.e26

Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences, Blegdamsvej 3b, DK-2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.09.008DOI Listing
October 2019

Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.

Nucleic Acids Res 2019 Sep;47(15):8004-8018

Department of Cellular and Molecular Medicine, Center for Chromosome Stability and Center for Healthy Aging, University of Copenhagen, Copenhagen 2200, Denmark.

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http://dx.doi.org/10.1093/nar/gkz510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735892PMC
September 2019

Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.

Nucleic Acids Res 2019 09;47(15):8332

Department of Cellular and Molecular Medicine, Center for Chromosome Stability and Center for Healthy Aging, University of Copenhagen, Copenhagen 2200, Denmark.

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http://dx.doi.org/10.1093/nar/gkz591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736055PMC
September 2019

Palaeoproteomic identification of breast milk protein residues from the archaeological skeletal remains of a neonatal dog.

Sci Rep 2019 Sep 6;9(1):12841. Epub 2019 Sep 6.

Section for Evolutionary Genomics, The GLOBE Institute, University of Copenhagen, Øster Voldgade 5-7, 1350, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41598-019-49183-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731306PMC
September 2019

Increased serological, cancer-associated protein biomarker levels at diagnosis of large bowel adenoma: Risk of subsequent primary malignancy?

Acta Oncol 2019 7;58(sup1):S42-S48. Epub 2018 Dec 7.

a Department of Surgical Gastroenterology, Center for Surgical Research , Hvidovre Hospital , Hvidovre , Denmark.

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http://dx.doi.org/10.1080/0284186X.2018.1540885DOI Listing
August 2019

Alternative Translation Initiation Generates a Functionally Distinct Isoform of the Stress-Activated Protein Kinase MK2.

Cell Rep 2019 Jun;27(10):2859-2870.e6

Institute of Cell Biochemistry, Hannover Medical School (MHH), Carl-Neuberg-Str. 1, 30625 Hannover, Germany; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.024DOI Listing
June 2019

Protein Aggregation Capture on Microparticles Enables Multipurpose Proteomics Sample Preparation.

Mol Cell Proteomics 2019 May 4;18(5):1027-1035. Epub 2019 Mar 4.

From the ‡The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Denmark;

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http://dx.doi.org/10.1074/mcp.TIR118.001270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495262PMC
May 2019

GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling.

Cell Rep 2019 Mar;26(13):3511-3521.e4

Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.03.006DOI Listing
March 2019

Limits for Resolving Isobaric Tandem Mass Tag Reporter Ions Using Phase-Constrained Spectrum Deconvolution.

J Proteome Res 2018 11 28;17(11):4008-4016. Epub 2018 Sep 28.

The Novo Nordisk Foundation Center for Protein Research , University of Copenhagen , 2200 Copenhagen , Denmark.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.8b00381
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http://dx.doi.org/10.1021/acs.jproteome.8b00381DOI Listing
November 2018

Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma.

Sci Signal 2018 11 20;11(557). Epub 2018 Nov 20.

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1126/scisignal.aap9752DOI Listing
November 2018

Quantitative metaproteomics of medieval dental calculus reveals individual oral health status.

Nat Commun 2018 11 20;9(1):4744. Epub 2018 Nov 20.

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen N, Denmark.

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http://www.nature.com/articles/s41467-018-07148-3
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http://dx.doi.org/10.1038/s41467-018-07148-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246597PMC
November 2018

SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability.

Nucleic Acids Res 2018 10;46(18):9484-9495

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1093/nar/gky719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182143PMC
October 2018

Carbon-14 bomb pulse dating shows that tendinopathy is preceded by years of abnormally high collagen turnover.

FASEB J 2018 09 23;32(9):4763-4775. Epub 2018 Mar 23.

Department of Orthopedic Surgery M, Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.

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https://www.fasebj.org/doi/10.1096/fj.201701569R
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http://dx.doi.org/10.1096/fj.201701569RDOI Listing
September 2018

PKD Phosphorylation as Novel Pathway of KV11.1 Regulation.

Cell Physiol Biochem 2018 27;47(4):1742-1750. Epub 2018 Jun 27.

Danish National Research Foundation Centre for Cardiac Arrhythmia and Dept. of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1159/000491007DOI Listing
August 2018

Generic Workflow for Mapping of Complex Disulfide Bonds Using In-Source Reduction and Extracted Ion Chromatograms from Data-Dependent Mass Spectrometry.

Anal Chem 2018 07 22;90(13):8202-8210. Epub 2018 Jun 22.

Protein Engineering , Global Research, Novo Nordisk A/S , Novo Nordisk Park , 2760 Måløv , Denmark.

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http://dx.doi.org/10.1021/acs.analchem.8b01603DOI Listing
July 2018

Palaeoproteomic Profiling of Conservation Layers on a 14th Century Italian Wall Painting.

Angew Chem Int Ed Engl 2018 06 26;57(25):7369-7374. Epub 2018 Apr 26.

Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350, Copenhagen, Denmark.

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http://dx.doi.org/10.1002/anie.201713020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032867PMC
June 2018

Molecular basis of Tousled-Like Kinase 2 activation.

Nat Commun 2018 06 28;9(1):2535. Epub 2018 Jun 28.

Structural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41467-018-04941-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023931PMC
June 2018

Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Predictor of Incident Atrial Fibrillation.

J Atr Fibrillation 2018 Apr 30;10(6):1801. Epub 2018 Apr 30.

Department of Cardiology, Copenhagen University Hospital Amager and Hvidovre, Hvidovre, Denmark.

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http://dx.doi.org/10.4022/jafib.1801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009789PMC
April 2018

Large-Scale Phosphoproteomics Reveals Shp-2 Phosphatase-Dependent Regulators of Pdgf Receptor Signaling.

Cell Rep 2018 03;22(10):2784-2796

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Science, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.02.038DOI Listing
March 2018

Benchmarking common quantification strategies for large-scale phosphoproteomics.

Nat Commun 2018 03 13;9(1):1045. Epub 2018 Mar 13.

Novo Nordisk Foundation Center for Protein Research, Proteomics Program, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, 2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41467-018-03309-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849679PMC
March 2018

Widespread erosion on high plateaus during recent glaciations in Scandinavia.

Nat Commun 2018 02 26;9(1):830. Epub 2018 Feb 26.

Scottish Universities Environmental Research Center, AMS Laboratory, East Kilbride, G75 0QF, Scotland, UK.

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http://dx.doi.org/10.1038/s41467-018-03280-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827020PMC
February 2018

Performance Evaluation of the Q Exactive HF-X for Shotgun Proteomics.

J Proteome Res 2018 01 20;17(1):727-738. Epub 2017 Dec 20.

The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen , Blegdamsvej 3b, Copenhagen 2200, Denmark.

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http://dx.doi.org/10.1021/acs.jproteome.7b00602DOI Listing
January 2018

Control of endothelial cell tube formation by Notch ligand intracellular domain interactions with activator protein 1 (AP-1).

J Biol Chem 2018 01 1;293(4):1229-1242. Epub 2017 Dec 1.

From the Department of Molecular Cell Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands and

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http://dx.doi.org/10.1074/jbc.M117.819045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787801PMC
January 2018

Conformation-specific anti-Mad2 monoclonal antibodies for the dissection of checkpoint signaling.

MAbs 2016 May-Jun;8(4):689-97. Epub 2016 Mar 17.

a The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark.

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http://dx.doi.org/10.1080/19420862.2016.1160988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966835PMC
November 2017

Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula.

J Nat Prod 2017 10 20;80(10):2830-2834. Epub 2017 Sep 20.

Department of Drug Design and Pharmacology, University of Copenhagen , DK-2100 Copenhagen Ø, Denmark.

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http://dx.doi.org/10.1021/acs.jnatprod.7b00106DOI Listing
October 2017

Proteomics Reveals Global Regulation of Protein SUMOylation by ATM and ATR Kinases during Replication Stress.

Cell Rep 2017 Oct;21(2):546-558

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.09.059DOI Listing
October 2017

KIT Induces SRC-Mediated Tyrosine Phosphorylation of MITF and Altered Transcription Program in Melanoma.

Mol Cancer Res 2017 09 5;15(9):1265-1274. Epub 2017 Jun 5.

Division of Translational Cancer Research, Lund Stem Cell Center, Lund University, Medicon Village and Department of Oncology, Skåne University Hospital, Lund, Sweden.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-17-0149DOI Listing
September 2017

Complete Mapping of Complex Disulfide Patterns with Closely-Spaced Cysteines by In-Source Reduction and Data-Dependent Mass Spectrometry.

Anal Chem 2017 06 9;89(11):5949-5957. Epub 2017 May 9.

Protein Engineering, Global Research, Novo Nordisk A/S , Novo Nordisk Park, 2760 Måløv, Denmark.

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http://dx.doi.org/10.1021/acs.analchem.7b00424DOI Listing
June 2017

An Optimized Shotgun Strategy for the Rapid Generation of Comprehensive Human Proteomes.

Cell Syst 2017 06 7;4(6):587-599.e4. Epub 2017 Jun 7.

Proteomics Program, Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2017.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493283PMC
June 2017

Proteomic profiling of archaeological human bone.

R Soc Open Sci 2017 Jun 7;4(6):161004. Epub 2017 Jun 7.

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1098/rsos.161004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493901PMC
June 2017

Phosphoproteomics of Primary Cells Reveals Druggable Kinase Signatures in Ovarian Cancer.

Cell Rep 2017 03;18(13):3242-3256

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382236PMC
March 2017

Proteomics insights into DNA damage response and translating this knowledge to clinical strategies.

Proteomics 2017 02 12;17(3-4). Epub 2016 Dec 12.

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1002/pmic.201600018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333460PMC
February 2017

The ubiquitin ligase Cullin5 regulates NDR1/STK38 stability and NF-κB transactivation.

Sci Rep 2017 02 20;7:42800. Epub 2017 Feb 20.

Novo Nordisk Foundation Center for Protein Research, Department of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.

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http://www.nature.com/articles/srep42800
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http://dx.doi.org/10.1038/srep42800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316984PMC
February 2017

52 Genetic Loci Influencing Myocardial Mass.

Authors:
Pim van der Harst Jessica van Setten Niek Verweij Georg Vogler Lude Franke Matthew T Maurano Xinchen Wang Irene Mateo Leach Mark Eijgelsheim Nona Sotoodehnia Caroline Hayward Rossella Sorice Osorio Meirelles Leo-Pekka Lyytikäinen Ozren Polašek Toshiko Tanaka Dan E Arking Sheila Ulivi Stella Trompet Martina Müller-Nurasyid Albert V Smith Marcus Dörr Kathleen F Kerr Jared W Magnani Fabiola Del Greco M Weihua Zhang Ilja M Nolte Claudia T Silva Sandosh Padmanabhan Vinicius Tragante Tõnu Esko Gonçalo R Abecasis Michiel E Adriaens Karl Andersen Phil Barnett Joshua C Bis Rolf Bodmer Brendan M Buckley Harry Campbell Megan V Cannon Aravinda Chakravarti Lin Y Chen Alessandro Delitala Richard B Devereux Pieter A Doevendans Anna F Dominiczak Luigi Ferrucci Ian Ford Christian Gieger Tamara B Harris Eric Haugen Matthias Heinig Dena G Hernandez Hans L Hillege Joel N Hirschhorn Albert Hofman Norbert Hubner Shih-Jen Hwang Annamaria Iorio Mika Kähönen Manolis Kellis Ivana Kolcic Ishminder K Kooner Jaspal S Kooner Jan A Kors Edward G Lakatta Kasper Lage Lenore J Launer Daniel Levy Alicia Lundby Peter W Macfarlane Dalit May Thomas Meitinger Andres Metspalu Stefania Nappo Silvia Naitza Shane Neph Alex S Nord Teresa Nutile Peter M Okin Jesper V Olsen Ben A Oostra Josef M Penninger Len A Pennacchio Tune H Pers Siegfried Perz Annette Peters Yigal M Pinto Arne Pfeufer Maria Grazia Pilia Peter P Pramstaller Bram P Prins Olli T Raitakari Soumya Raychaudhuri Ken M Rice Elizabeth J Rossin Jerome I Rotter Sebastian Schafer David Schlessinger Carsten O Schmidt Jobanpreet Sehmi Herman H W Silljé Gianfranco Sinagra Moritz F Sinner Kamil Slowikowski Elsayed Z Soliman Timothy D Spector Wilko Spiering John A Stamatoyannopoulos Ronald P Stolk Konstantin Strauch Sian-Tsung Tan Kirill V Tarasov Bosco Trinh Andre G Uitterlinden Malou van den Boogaard Cornelia M van Duijn Wiek H van Gilst Jorma S Viikari Peter M Visscher Veronique Vitart Uwe Völker Melanie Waldenberger Christian X Weichenberger Harm-Jan Westra Cisca Wijmenga Bruce H Wolffenbuttel Jian Yang Connie R Bezzina Patricia B Munroe Harold Snieder Alan F Wright Igor Rudan Laurie A Boyer Folkert W Asselbergs Dirk J van Veldhuisen Bruno H Stricker Bruce M Psaty Marina Ciullo Serena Sanna Terho Lehtimäki James F Wilson Stefania Bandinelli Alvaro Alonso Paolo Gasparini J Wouter Jukema Stefan Kääb Vilmundur Gudnason Stephan B Felix Susan R Heckbert Rudolf A de Boer Christopher Newton-Cheh Andrew A Hicks John C Chambers Yalda Jamshidi Axel Visel Vincent M Christoffels Aaron Isaacs Nilesh J Samani Paul I W de Bakker

J Am Coll Cardiol 2016 09;68(13):1435-1448

Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Epidemiology, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1016/j.jacc.2016.07.729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478167PMC
September 2016

Metaproteomics of saliva identifies human protein markers specific for individuals with periodontitis and dental caries compared to orally healthy controls.

PeerJ 2016 14;4:e2433. Epub 2016 Sep 14.

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.7717/peerj.2433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028799PMC
September 2016

Offline High pH Reversed-Phase Peptide Fractionation for Deep Phosphoproteome Coverage.

Methods Mol Biol 2016 ;1355:179-92

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University ofCopenhagen, Blegdamsvej 3b, 2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/978-1-4939-3049-4_12DOI Listing
August 2016

Simple and Reproducible Sample Preparation for Single-Shot Phosphoproteomics with High Sensitivity.

Methods Mol Biol 2016 ;1355:251-60

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, 2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/978-1-4939-3049-4_17DOI Listing
August 2016

From Phosphosites to Kinases.

Methods Mol Biol 2016 ;1355:307-21

Disease Systems Biology Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, Bldg. 6.2, 2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/978-1-4939-3049-4_21DOI Listing
August 2016

Systems Analysis for Interpretation of Phosphoproteomics Data.

Methods Mol Biol 2016 ;1355:341-60

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, Bldg. 6.1, 2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/978-1-4939-3049-4_23DOI Listing
August 2016

Can Preoperative Sex-Related Differences in Hemostatic Parameters Predict Bleeding in Orthognathic Surgery?

J Oral Maxillofac Surg 2016 Aug 22;74(8):1637-42. Epub 2016 Mar 22.

Associate Professor and Head of Section, Unit for Thrombosis Research, Department of Public Health, University of Southern Denmark, and Department of Clinical Biochemistry, Hospital of South West Denmark, Esbjerg, Denmark.

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http://dx.doi.org/10.1016/j.joms.2016.03.012DOI Listing
August 2016

A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase.

Mol Cell 2016 08 21;63(4):686-695. Epub 2016 Jul 21.

Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.06.024DOI Listing
August 2016

Eye lens radiocarbon reveals centuries of longevity in the Greenland shark (Somniosus microcephalus).

Science 2016 Aug 11;353(6300):702-4. Epub 2016 Aug 11.

Marine Biological Section, University of Copenhagen, Strandpromenaden 5, 3000 Helsingør, Denmark.

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http://dx.doi.org/10.1126/science.aaf1703DOI Listing
August 2016

Recent findings and technological advances in phosphoproteomics for cells and tissues.

Expert Rev Proteomics 2015 ;12(5):469-87

a Proteomics Program, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1586/14789450.2015.1078730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819829PMC
June 2016

Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking.

Nat Struct Mol Biol 2016 06 2;23(6):608-18. Epub 2016 May 2.

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/nsmb.3218DOI Listing
June 2016

Analytic framework for peptidomics applied to large-scale neuropeptide identification.

Nat Commun 2016 May 4;7:11436. Epub 2016 May 4.

Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Blegdamsvej 3b, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1038/ncomms11436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857386PMC
May 2016

Holocene ice marginal fluctuations of the Qassimiut lobe in South Greenland.

Sci Rep 2016 Mar 4;6:22362. Epub 2016 Mar 4.

Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen K, Denmark.

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http://dx.doi.org/10.1038/srep22362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778018PMC
March 2016

Observational evidence for enhanced magnetic activity of superflare stars.

Nat Commun 2016 Mar 24;7:11058. Epub 2016 Mar 24.

Key Laboratory of Optical Astronomy, National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012, China.

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http://dx.doi.org/10.1038/ncomms11058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820840PMC
March 2016

Disulfide Linkage Characterization of Disulfide Bond-Containing Proteins and Peptides by Reducing Electrochemistry and Mass Spectrometry.

Anal Chem 2016 Feb 8;88(3):1585-92. Epub 2016 Jan 8.

Protein Engineering, Novo Nordisk A/S , Novo Nordisk Park, 2760 Måløv, Denmark.

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http://dx.doi.org/10.1021/acs.analchem.5b03148DOI Listing
February 2016

Prevention of Bleeding in Orthognathic Surgery--A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

J Oral Maxillofac Surg 2016 Jan 29;74(1):139-50. Epub 2015 May 29.

Professor and Consultant, Department of Oral and Maxillofacial Surgery, Hospital of South West Denmark, Esbjerg, Denmark; and Institute for Regional Health Sciences, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.

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http://dx.doi.org/10.1016/j.joms.2015.05.031DOI Listing
January 2016

Protein kinase A stimulates Kv7.1 surface expression by regulating Nedd4-2-dependent endocytic trafficking.

Am J Physiol Cell Physiol 2015 Nov 24;309(10):C693-706. Epub 2015 Sep 24.

The Danish National Research Foundation Center for Cardiac Arrhythmia and The Faculty of Health and Medical Sciences, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark; and

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http://dx.doi.org/10.1152/ajpcell.00383.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652078PMC
November 2015

Blood-based Biomarkers at Large Bowel Endoscopy and Prediction of Future Malignancies.

Biomark Cancer 2015 22;7:57-61. Epub 2015 Oct 22.

Department of Surgical Gastroenterology, Hvidovre Hospital, Hvidovre, Denmark. ; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.4137/BIC.S31330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620935PMC
November 2015

Comprehensive identification of SUMO2/3 targets and their dynamics during mitosis.

PLoS One 2014 27;9(6):e100692. Epub 2014 Jun 27.

The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100692PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074068PMC
October 2015

Impact of in Vivo Ischemic Time on RNA Quality--Experiences from a Colon Cancer Biobank.

Biopreserv Biobank 2015 Aug 17;13(4):255-62. Epub 2015 Jul 17.

3 Faculty of Health and Medical Sciences, Copenhagen University , Copenhagen, Denmark .

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http://www.liebertpub.com/doi/10.1089/bio.2015.0009
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http://dx.doi.org/10.1089/bio.2015.0009DOI Listing
August 2015

Clinical implications of intestinal stem cell markers in colorectal cancer.

Clin Colorectal Cancer 2015 Jun 24;14(2):63-71. Epub 2014 Dec 24.

Department of Science, Systems and Models, Roskilde University, Roskilde, Denmark.

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http://dx.doi.org/10.1016/j.clcc.2014.12.004DOI Listing
June 2015

Ubiquitin-specific Protease 11 (USP11) Deubiquitinates Hybrid Small Ubiquitin-like Modifier (SUMO)-Ubiquitin Chains to Counteract RING Finger Protein 4 (RNF4).

J Biol Chem 2015 Jun 12;290(25):15526-37. Epub 2015 May 12.

From the Department of Molecular Cell Biology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands and

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http://dx.doi.org/10.1074/jbc.M114.618132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477612PMC
June 2015

High interleukin-6 mRNA expression is a predictor of relapse in colon cancer.

Anticancer Res 2015 Apr;35(4):2235-40

Department of Science, Systems and Models, Roskilde University, Roskilde, Denmark.

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April 2015

Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation.

Sci Signal 2015 Apr 28;8(374):ra40. Epub 2015 Apr 28.

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1126/scisignal.2005769DOI Listing
April 2015

SILAC-based temporal phosphoproteomics.

Methods Mol Biol 2014 ;1188:125-48

Department of Proteomics, Novo Nordisk Foundation Center for Protein Research, Faculty of Health Science, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/978-1-4939-1142-4_10DOI Listing
March 2015

Serum YKL-40 in risk assessment for colorectal cancer: a prospective study of 4,496 subjects at risk of colorectal cancer.

Cancer Epidemiol Biomarkers Prev 2015 Mar 18;24(3):621-6. Epub 2015 Jan 18.

Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Department of Surgical Gastroenterology, Hvidovre Hospital, Hvidovre, Denmark.

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http://dx.doi.org/10.1158/1055-9965.EPI-13-1281DOI Listing
March 2015

SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage.

Cell Rep 2015 Mar 12;10(10):1778-1791. Epub 2015 Mar 12.

Department of Molecular Cell Biology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514456PMC
March 2015

Ctk1 function is necessary for full translation initiation activity in Saccharomyces cerevisiae.

Eukaryot Cell 2015 Jan 21;14(1):86-95. Epub 2014 Nov 21.

Gene Center and Department of Biochemistry, Ludwig Maximilians University of Munich, Munich, Germany Center for Integrated Protein Science Munich (CIPSM), Munich, Germany Institute of Biochemistry, Justus Liebig University Gießen, Gießen, Germany

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http://dx.doi.org/10.1128/EC.00106-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279022PMC
January 2015

Ubiquitin-SUMO circuitry controls activated fanconi anemia ID complex dosage in response to DNA damage.

Mol Cell 2015 Jan 31;57(1):150-64. Epub 2014 Dec 31.

Ubiquitin Signaling Group, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765140094
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http://dx.doi.org/10.1016/j.molcel.2014.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416315PMC
January 2015

Off-line high-pH reversed-phase fractionation for in-depth phosphoproteomics.

J Proteome Res 2014 Dec 4;13(12):6176-86. Epub 2014 Nov 4.

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Science, University of Copenhagen , Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/pr500893mDOI Listing
December 2014

Rapid and deep proteomes by faster sequencing on a benchtop quadrupole ultra-high-field Orbitrap mass spectrometer.

J Proteome Res 2014 Dec 10;13(12):6187-95. Epub 2014 Nov 10.

Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen , Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/pr500985wDOI Listing
December 2014

Analysis of changes in SUMO-2/3 modification during breast cancer progression and metastasis.

J Proteome Res 2014 Sep 7;13(9):3905-18. Epub 2014 Aug 7.

Department of Biological Sciences, Wayne State University , 5047 Gullen Mall, Detroit, Michigan 48202, United States.

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http://dx.doi.org/10.1021/pr500119aDOI Listing
September 2014

Analytical utility of mass spectral binning in proteomic experiments by SPectral Immonium Ion Detection (SPIID).

Mol Cell Proteomics 2014 Aug 3;13(8):1914-24. Epub 2014 Jun 3.

From the ‡Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health Sciences, DK-2200 Copenhagen, Denmark;

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http://dx.doi.org/10.1074/mcp.O113.035915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125726PMC
August 2014

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

Authors:
Dan E Arking Sara L Pulit Lia Crotti Pim van der Harst Patricia B Munroe Tamara T Koopmann Nona Sotoodehnia Elizabeth J Rossin Michael Morley Xinchen Wang Andrew D Johnson Alicia Lundby Daníel F Gudbjartsson Peter A Noseworthy Mark Eijgelsheim Yuki Bradford Kirill V Tarasov Marcus Dörr Martina Müller-Nurasyid Annukka M Lahtinen Ilja M Nolte Albert Vernon Smith Joshua C Bis Aaron Isaacs Stephen J Newhouse Daniel S Evans Wendy S Post Daryl Waggott Leo-Pekka Lyytikäinen Andrew A Hicks Lewin Eisele David Ellinghaus Caroline Hayward Pau Navarro Sheila Ulivi Toshiko Tanaka David J Tester Stéphanie Chatel Stefan Gustafsson Meena Kumari Richard W Morris Åsa T Naluai Sandosh Padmanabhan Alexander Kluttig Bernhard Strohmer Andrie G Panayiotou Maria Torres Michael Knoflach Jaroslav A Hubacek Kamil Slowikowski Soumya Raychaudhuri Runjun D Kumar Tamara B Harris Lenore J Launer Alan R Shuldiner Alvaro Alonso Joel S Bader Georg Ehret Hailiang Huang W H Linda Kao James B Strait Peter W Macfarlane Morris Brown Mark J Caulfield Nilesh J Samani Florian Kronenberg Johann Willeit J Gustav Smith Karin H Greiser Henriette Meyer Zu Schwabedissen Karl Werdan Massimo Carella Leopoldo Zelante Susan R Heckbert Bruce M Psaty Jerome I Rotter Ivana Kolcic Ozren Polašek Alan F Wright Maura Griffin Mark J Daly David O Arnar Hilma Hólm Unnur Thorsteinsdottir Joshua C Denny Dan M Roden Rebecca L Zuvich Valur Emilsson Andrew S Plump Martin G Larson Christopher J O'Donnell Xiaoyan Yin Marco Bobbo Adamo P D'Adamo Annamaria Iorio Gianfranco Sinagra Angel Carracedo Steven R Cummings Michael A Nalls Antti Jula Kimmo K Kontula Annukka Marjamaa Lasse Oikarinen Markus Perola Kimmo Porthan Raimund Erbel Per Hoffmann Karl-Heinz Jöckel Hagen Kälsch Markus M Nöthen Marcel den Hoed Ruth J F Loos Dag S Thelle Christian Gieger Thomas Meitinger Siegfried Perz Annette Peters Hanna Prucha Moritz F Sinner Melanie Waldenberger Rudolf A de Boer Lude Franke Pieter A van der Vleuten Britt Maria Beckmann Eimo Martens Abdennasser Bardai Nynke Hofman Arthur A M Wilde Elijah R Behr Chrysoula Dalageorgou John R Giudicessi Argelia Medeiros-Domingo Julien Barc Florence Kyndt Vincent Probst Alice Ghidoni Roberto Insolia Robert M Hamilton Stephen W Scherer Jeffrey Brandimarto Kenneth Margulies Christine E Moravec Fabiola del Greco M Christian Fuchsberger Jeffrey R O'Connell Wai K Lee Graham C M Watt Harry Campbell Sarah H Wild Nour E El Mokhtari Norbert Frey Folkert W Asselbergs Irene Mateo Leach Gerjan Navis Maarten P van den Berg Dirk J van Veldhuisen Manolis Kellis Bouwe P Krijthe Oscar H Franco Albert Hofman Jan A Kors André G Uitterlinden Jacqueline C M Witteman Lyudmyla Kedenko Claudia Lamina Ben A Oostra Gonçalo R Abecasis Edward G Lakatta Antonella Mulas Marco Orrú David Schlessinger Manuela Uda Marcello R P Markus Uwe Völker Harold Snieder Timothy D Spector Johan Ärnlöv Lars Lind Johan Sundström Ann-Christine Syvänen Mika Kivimaki Mika Kähönen Nina Mononen Olli T Raitakari Jorma S Viikari Vera Adamkova Stefan Kiechl Maria Brion Andrew N Nicolaides Bernhard Paulweber Johannes Haerting Anna F Dominiczak Fredrik Nyberg Peter H Whincup Aroon D Hingorani Jean-Jacques Schott Connie R Bezzina Erik Ingelsson Luigi Ferrucci Paolo Gasparini James F Wilson Igor Rudan Andre Franke Thomas W Mühleisen Peter P Pramstaller Terho J Lehtimäki Andrew D Paterson Afshin Parsa Yongmei Liu Cornelia M van Duijn David S Siscovick Vilmundur Gudnason Yalda Jamshidi Veikko Salomaa Stephan B Felix Serena Sanna Marylyn D Ritchie Bruno H Stricker Kari Stefansson Laurie A Boyer Thomas P Cappola Jesper V Olsen Kasper Lage Peter J Schwartz Stefan Kääb Aravinda Chakravarti Michael J Ackerman Arne Pfeufer Paul I W de Bakker Christopher Newton-Cheh

Nat Genet 2014 Aug 22;46(8):826-36. Epub 2014 Jun 22.

1] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts, USA. [4] Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA. [5].

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http://dx.doi.org/10.1038/ng.3014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124521PMC
August 2014

PRIME-XS, a European infrastructure for proteomics.

Mol Cell Proteomics 2014 Aug 23;13(8):1901-4. Epub 2014 Jun 23.

From the *Biomolecular Mass Spectrometry and Proteomics Group, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, Utrecht, 3584 CH, The Netherlands;

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http://dx.doi.org/10.1074/mcp.E114.040162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125724PMC
August 2014

Treatment of appendiceal mass--a qualitative systematic review.

Dan Med J 2014 Aug;61(8):A4881

Ny Carlsbergvej 19, 2. th., 1760 København V, Denmark.

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August 2014