Publications by authors named "Jesper B Andersen"

88Publications

Structural aberrations are associated with poor survival in patients with clonal cytopenia of undetermined significance.

Haematologica 2020 Nov 12;Online ahead of print. Epub 2020 Nov 12.

Department of Hematology, Rigshospitalet, Copenhagen, Denmark; Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; DanStem, University of Copenhagen, Copenhagen.

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November 2020

Intrahepatic cholangiocarcinoma: A single-cell resolution unraveling the complexity of the tumor microenvironment.

J Hepatol 2020 Nov 6;73(5):1007-1009. Epub 2020 Sep 6.

Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine (CRSA), UMRS 928, F-75012 Paris, France. Electronic address:

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November 2020

Molecular Targets in Cholangiocarcinoma.

Hepatology 2020 Apr 18. Epub 2020 Apr 18.

Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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April 2020

Ancestrally Duplicated Conserved Noncoding Element Suggests Dual Regulatory Roles of HOTAIR in cis and trans.

iScience 2020 Apr 25;23(4):101008. Epub 2020 Mar 25.

Biotech Research and Innovation Centre, Department of Health and Medical Sciences, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark. Electronic address:

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April 2020

Therapeutic Rationale to Target Highly Expressed Aurora kinase A Conferring Poor Prognosis in Cholangiocarcinoma.

J Cancer 2020 3;11(8):2241-2251. Epub 2020 Feb 3.

Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.

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February 2020

Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing.

Nat Commun 2020 01 10;11(1):168. Epub 2020 Jan 10.

Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

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January 2020

A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation.

Nat Commun 2019 11 19;10(1):5220. Epub 2019 Nov 19.

University of Copenhagen, NNF Center for Stem Cell Biology (DanStem), Blegdamsvej 3B, 2200, Copenhagen N, Denmark.

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November 2019

Metabolic rearrangements in primary liver cancers: cause and consequences.

Nat Rev Gastroenterol Hepatol 2019 12 30;16(12):748-766. Epub 2019 Oct 30.

Biotech Research and Innovation Centre (BRIC) Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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December 2019

Identification of a Pan-Gamma-Secretase Inhibitor Response Signature for Notch-Driven Cholangiocarcinoma.

Hepatology 2020 01 19;71(1):196-213. Epub 2019 Aug 19.

Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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January 2020

Epigenome Remodeling in Cholangiocarcinoma.

Trends Cancer 2019 06 4;5(6):335-350. Epub 2019 Jun 4.

Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address:

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June 2019

The positive predictive value of spontaneous subarachnoid hemorrhage diagnoses in the Danish National Patient Register.

Clin Epidemiol 2019 1;11:323-331. Epub 2019 May 1.

Department of Anaesthesia, Centre of Head and Orthopaedics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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May 2019

Molecular perturbations in cholangiocarcinoma: Is it time for precision medicine?

Liver Int 2019 05 24;39 Suppl 1:32-42. Epub 2019 Mar 24.

Department of Health and Medical Sciences, Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen N, Denmark.

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May 2019

Single cell profiling reveals window for immunotherapy in liver cancers.

Hepatobiliary Surg Nutr 2018 Feb;7(1):48-51

Biotech Research & Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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February 2018

Desmoplastic Tumor Microenvironment and Immunotherapy in Cholangiocarcinoma.

Trends Cancer 2018 03 21;4(3):239-255. Epub 2018 Feb 21.

Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, Ole Maaløes Vej 5, 2200, Copenhagen N, Denmark. Electronic address:

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March 2018

Genomic perturbations reveal distinct regulatory networks in intrahepatic cholangiocarcinoma.

Hepatology 2018 09 12;68(3):949-963. Epub 2018 Jun 12.

Biotech Research and Innovation Centre, Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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September 2018

Reply.

Gastroenterology 2018 01 24;154(1):260-261. Epub 2017 Nov 24.

Pontificia Universidad Católica, Fondap Advanced Center for Chronic Diseases, Santiago, Chile.

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January 2018

Epigenome dysregulation in cholangiocarcinoma.

Biochim Biophys Acta Mol Basis Dis 2018 04 20;1864(4 Pt B):1423-1434. Epub 2017 Jun 20.

Biotech Research & Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark. Electronic address:

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April 2018

Association of Aflatoxin and Gallbladder Cancer.

Gastroenterology 2017 08 17;153(2):488-494.e1. Epub 2017 Apr 17.

Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

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August 2017

SOX17 regulates cholangiocyte differentiation and acts as a tumor suppressor in cholangiocarcinoma.

J Hepatol 2017 07 22;67(1):72-83. Epub 2017 Feb 22.

Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute - Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain; National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, Instituto de Salud Carlos III), Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain. Electronic address:

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July 2017

Molecular profiling of intrahepatic cholangiocarcinoma: the search for new therapeutic targets.

Expert Rev Gastroenterol Hepatol 2017 Apr 13;11(4):349-356. Epub 2017 Feb 13.

a Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences , University of Copenhagen , Copenhagen N , Denmark.

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April 2017

Genetic Optimization of Liver Cancer Therapy: A Patient-Derived Primary Cancer Cell-Based Model.

Gastroenterology 2017 01 23;152(1):19-21. Epub 2016 Nov 23.

Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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January 2017

Cholangiocarcinoma stem-like subset shapes tumor-initiating niche by educating associated macrophages.

J Hepatol 2017 01 1;66(1):102-115. Epub 2016 Sep 1.

Center for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Rozzano, Italy; Program for Autoimmune Liver Diseases, International Center for Digestive Health, Department of Medicine and Surgery, University of Milan-Bicocca, Italy. Electronic address:

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January 2017

Molecular Pathogenesis and Current Therapy in Intrahepatic Cholangiocarcinoma.

Dig Dis 2016;34(4):440-51. Epub 2016 May 11.

Biotech Research and Innovation Centre (BRIC), Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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January 2017

DNMT1 is a required genomic regulator for murine liver histogenesis and regeneration.

Hepatology 2016 08 28;64(2):582-98. Epub 2016 Apr 28.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.

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August 2016

Heterogeneity Among Liver Cancer--A Hurdle to Optimizing Therapy.

Gastroenterology 2016 Apr 26;150(4):818-21. Epub 2016 Feb 26.

Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark. Electronic address:

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April 2016

Transcriptional, post-transcriptional and chromatin-associated regulation of pri-miRNAs, pre-miRNAs and moRNAs.

Nucleic Acids Res 2016 Apr 15;44(7):3070-81. Epub 2015 Dec 15.

Institute of Clinical Sciences MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK Department of Informatics, University of Bergen, Thormøhlensgate 55, N-5008 Bergen, Norway

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April 2016

A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy.

Mol Pharmacol 2016 Feb 14;89(2):263-72. Epub 2015 Dec 14.

Laboratory of Cell Biology (J-P.G., J.P.M., C-P.W., A.M.C., S.V.A., M.M.G.) and Laboratory of Experimental Carcinogenesis (J.B.A., S.S.T.), Center for Cancer Research, National Cancer Institute, and Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, Office of Science Management and Operations, National Institute of Allergy and Infectious Diseases (S.V.), National Institutes of Health, Bethesda, Maryland; and the Viral Technologies Group and Molecular Detection Group, Protein Expression Laboratory, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, Marylanld (R.K.B., K.P., W.E.B.)

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February 2016

Functional and genetic deconstruction of the cellular origin in liver cancer.

Nat Rev Cancer 2015 Nov;15(11):653-67

Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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November 2015

Liver cancer oncogenomics: opportunities and dilemmas for clinical applications.

Hepat Oncol 2015;2(1):79-93

Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark.

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January 2015

Stimulating translational research: several European life science institutions put their heads together.

Trends Mol Med 2015 Sep 5;21(9):525-7. Epub 2015 Aug 5.

EU-Life Translational Working Group; Centre for Genomic Regulation (CRG), Dr Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain.

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September 2015

Fibrolamellar hepatocellular carcinoma: a rare but distinct type of liver cancer.

Gastroenterology 2015 Apr 24;148(4):707-10. Epub 2015 Feb 24.

Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark. Electronic address:

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April 2015

Impact of microenvironment and stem-like plasticity in cholangiocarcinoma: molecular networks and biological concepts.

J Hepatol 2015 Jan 16;62(1):198-207. Epub 2014 Sep 16.

Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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January 2015

MYC activates stem-like cell potential in hepatocarcinoma by a p53-dependent mechanism.

Cancer Res 2014 Oct 4;74(20):5903-13. Epub 2014 Sep 4.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.

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October 2014

Molecular pathogenesis of intrahepatic cholangiocarcinoma.

J Hepatobiliary Pancreat Sci 2015 Feb 1;22(2):101-13. Epub 2014 Sep 1.

Andersen Group, Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, DK-2200, Copenhagen N, Denmark.

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February 2015

p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer.

Cell 2014 Jul;158(3):579-92

Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; Howard Hughes Medical Institute, New York, NY 10065, USA. Electronic address:

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July 2014

Antitumor effects in hepatocarcinoma of isoform-selective inhibition of HDAC2.

Cancer Res 2014 Sep 23;74(17):4752-61. Epub 2014 Jun 23.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.

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September 2014

A perspective on molecular therapy in cholangiocarcinoma: present status and future directions.

Hepat Oncol 2014 Jan;1(1):143-157

National Cancer Institute, Laboratory of Experimental Carcinogenesis, NIH, Building 37, Room 4146A, 37 Convent Drive, Bethesda, MD 20892-4262, USA.

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January 2014

Epigenetic reprogramming modulates malignant properties of human liver cancer.

Hepatology 2014 Jun 1;59(6):2251-62. Epub 2014 May 1.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD.

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June 2014

Molecular constituents of the extracellular matrix in rat liver mounting a hepatic progenitor cell response for tissue repair.

Fibrogenesis Tissue Repair 2013 Dec 20;6(1):21. Epub 2013 Dec 20.

Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.

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December 2013

Targeting the mTOR pathway in hepatocellular carcinoma: current state and future trends.

J Hepatol 2014 Apr 3;60(4):855-65. Epub 2013 Dec 3.

Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD, USA. Electronic address:

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April 2014

Next-generation sequencing: application in liver cancer-past, present and future?

Biology (Basel) 2012 Aug;1(2):383-94

Department of Medicine I, Johannes Gutenberg University, Langenbeckstrasse 1, Mainz 55131, Germany ; Laboratory of Experimental Carcinogenesis, NCI/CCR, NIH, Bethesda, Maryland 20892, USA.

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August 2012

Modeling pathogenesis of primary liver cancer in lineage-specific mouse cell types.

Gastroenterology 2013 Jul 19;145(1):221-231. Epub 2013 Mar 19.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Electronic address:

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July 2013

Genetic profiling of intrahepatic cholangiocarcinoma.

Curr Opin Gastroenterol 2012 May;28(3):266-72

Laboratory of Experimental Carcinogenesis, NCI/CCR, NIH, Bethesda, Maryland 20892-4262, USA.

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May 2012

Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.

J Exp Med 2011 Sep 29;208(10):1963-76. Epub 2011 Aug 29.

Department of Genetics, Department of Pediatrics, Stanford University, Stanford, CA, USA; Department of Medical Chemistry, University of Liège, B-4000 Liège, Belgium.

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September 2011

Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathways.

Hepatology 2011 Sep 27;54(3):1031-42. Epub 2011 Jul 27.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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September 2011

An integrated genomic and epigenomic approach predicts therapeutic response to zebularine in human liver cancer.

Sci Transl Med 2010 Oct;2(54):54ra77

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4262, USA.

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October 2010

Loss of c-Met disrupts gene expression program required for G2/M progression during liver regeneration in mice.

PLoS One 2010 Sep 16;5(9). Epub 2010 Sep 16.

Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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September 2010

Progenitor-derived hepatocellular carcinoma model in the rat.

Hepatology 2010 Apr;51(4):1401-9

Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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April 2010

Ribosomal protein mRNAs are primary targets of regulation in RNase-L-induced senescence.

RNA Biol 2009 Jul-Aug;6(3):305-15. Epub 2009 Jul 23.

Marlene and Stewart Greenebaum Cancer Center, University of Maryland Baltimore, School of Medicine, Baltimore, MD 21201, USA.

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November 2009

Post-transcriptional regulation of RNase-L expression is mediated by the 3'-untranslated region of its mRNA.

J Biol Chem 2007 Mar 19;282(11):7950-60. Epub 2007 Jan 19.

University of Maryland, Department of Microbiology and Immunology, Marlene and Stewart Greenebaum Cancer Center, Graduate Program in Molecular Medicine, Baltimore, Maryland 21201, USA.

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March 2007