Publications

Cholangiocarcinoma stem-like subset shapes tumor-initiating niche by educating associated macrophages.
J Hepatol 2017 Jan 1;66(1):102-115. Epub 2016 Sep 1.
Center for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Rozzano, Italy; Program for Autoimmune Liver Diseases, International Center for Digestive Health, Department of Medicine and Surgery, University of Milan-Bicocca, Italy. Electronic address:


DNMT1 is a required genomic regulator for murine liver histogenesis and regeneration.
Hepatology 2016 Aug 28;64(2):582-98. Epub 2016 Apr 28.
Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.



Transcriptional, post-transcriptional and chromatin-associated regulation of pri-miRNAs, pre-miRNAs and moRNAs.
Nucleic Acids Res 2016 Apr 15;44(7):3070-81. Epub 2015 Dec 15.
Institute of Clinical Sciences MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK Department of Informatics, University of Bergen, Thormøhlensgate 55, N-5008 Bergen, Norway

A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy.
Mol Pharmacol 2016 Feb 14;89(2):263-72. Epub 2015 Dec 14.
Laboratory of Cell Biology (J-P.G., J.P.M., C-P.W., A.M.C., S.V.A., M.M.G.) and Laboratory of Experimental Carcinogenesis (J.B.A., S.S.T.), Center for Cancer Research, National Cancer Institute, and Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, Office of Science Management and Operations, National Institute of Allergy and Infectious Diseases (S.V.), National Institutes of Health, Bethesda, Maryland; and the Viral Technologies Group and Molecular Detection Group, Protein Expression Laboratory, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, Marylanld (R.K.B., K.P., W.E.B.)


Stimulating translational research: several European life science institutions put their heads together.
Trends Mol Med 2015 Sep 5;21(9):525-7. Epub 2015 Aug 5.
EU-Life Translational Working Group; Centre for Genomic Regulation (CRG), Dr Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain.

MYC activates stem-like cell potential in hepatocarcinoma by a p53-dependent mechanism.
Cancer Res 2014 Oct 4;74(20):5903-13. Epub 2014 Sep 4.
Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.


p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer.
Cell 2014 Jul;158(3):579-92
Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; Howard Hughes Medical Institute, New York, NY 10065, USA. Electronic address:

Epigenetic reprogramming modulates malignant properties of human liver cancer.
Hepatology 2014 Jun 1;59(6):2251-62. Epub 2014 May 1.
Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD.



Molecular constituents of the extracellular matrix in rat liver mounting a hepatic progenitor cell response for tissue repair.
Fibrogenesis Tissue Repair 2013 Dec 20;6(1):21. Epub 2013 Dec 20.
Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.


Modeling pathogenesis of primary liver cancer in lineage-specific mouse cell types.
Gastroenterology 2013 Jul 19;145(1):221-31. Epub 2013 Mar 19.
Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.




Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.
J Exp Med 2011 Sep 29;208(10):1963-76. Epub 2011 Aug 29.
Department of Genetics, Department of Pediatrics, Stanford University, Stanford, CA, USA; Department of Medical Chemistry, University of Liège, B-4000 Liège, Belgium.

Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathways.
Hepatology 2011 Sep 27;54(3):1031-42. Epub 2011 Jul 27.
Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.


An integrated genomic and epigenomic approach predicts therapeutic response to zebularine in human liver cancer.
Sci Transl Med 2010 Oct;2(54):54ra77
Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4262, USA.

Loss of c-Met disrupts gene expression program required for G2/M progression during liver regeneration in mice.
PLoS One 2010 Sep 16;5(9). Epub 2010 Sep 16.
Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.


Post-transcriptional regulation of RNase-L expression is mediated by the 3'-untranslated region of its mRNA.
J Biol Chem 2007 Mar 19;282(11):7950-60. Epub 2007 Jan 19.
University of Maryland, Department of Microbiology and Immunology, Marlene and Stewart Greenebaum Cancer Center, Graduate Program in Molecular Medicine, Baltimore, Maryland 21201, USA.


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