Jerry W Shay

Jerry W Shay

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Jerry W Shay

Publications by authors named "Jerry W Shay"

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In perspective: An update on telomere targeting in cancer.

Mol Carcinog 2019 Sep 6;58(9):1581-1588. Epub 2019 May 6.

University of Texas Southwestern, Department of Cell Biology, Dallas, Texas.

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http://dx.doi.org/10.1002/mc.23035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692182PMC
September 2019

Transient introduction of human telomerase mRNA improves hallmarks of progeria cells.

Aging Cell 2019 Aug 31;18(4):e12979. Epub 2019 May 31.

Department of Cell Biology, UT Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1111/acel.12979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612639PMC
August 2019

Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52.

Genes Dev 2019 07 6;33(13-14):814-827. Epub 2019 Jun 6.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, USA.

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http://dx.doi.org/10.1101/gad.324905.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601508PMC
July 2019

Catalysis-dependent inactivation of human telomerase and its reactivation by intracellular telomerase-activating factors (iTAFs).

J Biol Chem 2019 Jul 11;294(30):11579-11596. Epub 2019 Jun 11.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390

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http://dx.doi.org/10.1074/jbc.RA118.007234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663873PMC
July 2019

Telomeres and telomerase: three decades of progress.

Nat Rev Genet 2019 05;20(5):299-309

Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1038/s41576-019-0099-1DOI Listing
May 2019

NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes telomerase activity in cancer cells.

Oncogene 2019 04 19;38(16):2937-2952. Epub 2018 Dec 19.

School of Kinesiology, University of Michigan, 401 Washtenaw Ave., Ann Arbor Michigan, MI, 48109, USA.

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http://dx.doi.org/10.1038/s41388-018-0639-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474811PMC
April 2019

ddTRAP: A Method for Sensitive and Precise Quantification of Telomerase Activity.

Methods Mol Biol 2018 ;1768:513-529

Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1007/978-1-4939-7778-9_29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046637PMC
February 2019

Long-range telomere regulation of gene expression: Telomere looping and telomere position effect over long distances (TPE-OLD).

Differentiation 2018 Jan - Feb;99:1-9. Epub 2017 Nov 22.

Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.diff.2017.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826875PMC
November 2018

Proton radiation-induced cancer progression.

Life Sci Space Res (Amst) 2018 Nov 18;19:31-42. Epub 2018 Aug 18.

Department of Cell Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd., Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.lssr.2018.08.002DOI Listing
November 2018

Inducing rapid telomere irreparable damage in telomerase-expressing cancers.

Oncotarget 2018 Nov 9;9(88):35803-35804. Epub 2018 Nov 9.

UT Southwestern Medical Center, Department of Cell Biology, Dallas, TX, USA.

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http://dx.doi.org/10.18632/oncotarget.26317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254679PMC
November 2018

Truncated Adenomatous Polyposis Coli Mutation Induces Asef-Activated Golgi Fragmentation.

Mol Cell Biol 2018 09 15;38(17). Epub 2018 Aug 15.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

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http://mcb.asm.org/lookup/doi/10.1128/MCB.00135-18
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http://dx.doi.org/10.1128/MCB.00135-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094051PMC
September 2018

NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer.

Nat Commun 2018 08 6;9(1):3112. Epub 2018 Aug 6.

Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA.

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http://dx.doi.org/10.1038/s41467-018-05582-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079032PMC
August 2018

Induced Telomere Damage to Treat Telomerase Expressing Therapy-Resistant Pediatric Brain Tumors.

Mol Cancer Ther 2018 07 13;17(7):1504-1514. Epub 2018 Apr 13.

Brain Tumor Center, Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://mct.aacrjournals.org/lookup/doi/10.1158/1535-7163.MCT
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http://dx.doi.org/10.1158/1535-7163.MCT-17-0792DOI Listing
July 2018

Telomeres and aging.

Authors:
Jerry W Shay

Curr Opin Cell Biol 2018 06 15;52:1-7. Epub 2017 Dec 15.

Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9039, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2017.12.001DOI Listing
June 2018

Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells.

Mol Cancer Ther 2018 05 21;17(5):943-951. Epub 2018 Feb 21.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0887DOI Listing
May 2018

Reconstituting Mouse Lungs with Conditionally Reprogrammed Human Bronchial Epithelial Cells.

Tissue Eng Part A 2018 04 25;24(7-8):559-568. Epub 2017 Sep 25.

1 Department of Cell Biology, University of Texas Southwestern Medical Center , Dallas, Texas.

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https://www.liebertpub.com/doi/10.1089/ten.tea.2017.0114
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http://dx.doi.org/10.1089/ten.TEA.2017.0114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905853PMC
April 2018

Reflections on telomere dynamics and ageing-related diseases in humans.

Philos Trans R Soc Lond B Biol Sci 2018 03;373(1741)

Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1098/rstb.2016.0436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784057PMC
March 2018

Comparison of telomere length measurement methods.

Philos Trans R Soc Lond B Biol Sci 2018 03;373(1741)

Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA

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http://dx.doi.org/10.1098/rstb.2016.0451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784071PMC
March 2018

Telomere G-Rich Overhang Length Measurement: DSN Method.

Methods Mol Biol 2017 ;1587:55-62

Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA.

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http://dx.doi.org/10.1007/978-1-4939-6892-3_5DOI Listing
February 2018

Telomere Terminal G/C Strand Synthesis: Measuring Telomerase Action and C-Rich Fill-In.

Methods Mol Biol 2017 ;1587:71-82

Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA.

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http://dx.doi.org/10.1007/978-1-4939-6892-3_7DOI Listing
February 2018

A method for measuring the distribution of the shortest telomeres in cells and tissues.

Nat Commun 2017 11 7;8(1):1356. Epub 2017 Nov 7.

Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA.

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http://dx.doi.org/10.1038/s41467-017-01291-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676791PMC
November 2017

Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes.

Mol Cell Biol 2017 Oct 26;37(20). Epub 2017 Sep 26.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

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http://dx.doi.org/10.1128/MCB.00226-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615184PMC
October 2017

New insights into melanoma development.

Authors:
Jerry W Shay

Science 2017 09 28;357(6358):1358-1359. Epub 2017 Sep 28.

The University of Texas Southwestern Medical Center, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1126/science.aao6963DOI Listing
September 2017

Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer.

J Natl Cancer Inst 2017 08;109(8)

Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, USA.

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http://dx.doi.org/10.1093/jnci/djw332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963831PMC
August 2017

Amplification of F-Actin Disassembly and Cellular Repulsion by Growth Factor Signaling.

Dev Cell 2017 07 6;42(2):117-129.e8. Epub 2017 Jul 6.

Departments of Neuroscience and Pharmacology, Harold C. Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564210PMC
July 2017

The Maintenance of Telomere Length in CD28+ T Cells During T Lymphocyte Stimulation.

Sci Rep 2017 07 28;7(1):6785. Epub 2017 Jul 28.

Department of Cell Biology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA.

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http://dx.doi.org/10.1038/s41598-017-05174-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533788PMC
July 2017

Generation of digoxigenin-incorporated probes to enhance DNA detection sensitivity.

Biotechniques 2016 1;60(6):306-9. Epub 2016 Jun 1.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX.

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http://dx.doi.org/10.2144/000114427DOI Listing
June 2017

Mutations, Cancer and the Telomere Length Paradox.

Trends Cancer 2017 04 27;3(4):253-258. Epub 2017 Mar 27.

Department of Cell Biology, UT Southwestern Medical Center, Dallas TX, 75390, USA; Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.

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http://dx.doi.org/10.1016/j.trecan.2017.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903276PMC
April 2017

Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands.

Nucleic Acids Res 2017 03;45(5):2615-2628

Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9039, USA.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkw1295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389697PMC
March 2017

c9orf72 Disease-Related Foci Are Each Composed of One Mutant Expanded Repeat RNA.

Cell Chem Biol 2017 Feb 26;24(2):141-148. Epub 2017 Jan 26.

Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2016.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316317PMC
February 2017

Telomere-associated aging disorders.

Ageing Res Rev 2017 Jan 20;33:52-66. Epub 2016 May 20.

University of Texas Southwestern Medical Center, Department of Cell Biology, 5323 Harry Hines Blvd., Dallas, TX 75390, United States. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2016.05.009DOI Listing
January 2017

Regulation of the Human Telomerase Gene TERT by Telomere Position Effect-Over Long Distances (TPE-OLD): Implications for Aging and Cancer.

PLoS Biol 2016 Dec 15;14(12):e2000016. Epub 2016 Dec 15.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.2000016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5169358PMC
December 2016

Genotoxicity of Cytolethal Distending Toxin (CDT) on Isogenic Human Colorectal Cell Lines: Potential Promoting Effects for Colorectal Carcinogenesis.

Front Cell Infect Microbiol 2016 23;6:34. Epub 2016 Mar 23.

Institut National de la Recherche Agronomique UMR 1331, TOXALIM (Research Center in Food Toxicology), Université de Toulouse, INRA, INP-ENVT, INP-EI-Purpan, Université de Toulouse III Paul Sabatier Toulouse, France.

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http://dx.doi.org/10.3389/fcimb.2016.00034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803749PMC
November 2016

TERT Promoter Mutations Enhance Telomerase Activation by Long-Range Chromatin Interactions.

Cancer Discov 2016 11;6(11):1212-1214

Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/2159-8290.CD-16-1050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111399PMC
November 2016

hTERT promotes tumor angiogenesis by activating VEGF via interactions with the Sp1 transcription factor.

Nucleic Acids Res 2016 Oct 20;44(18):8693-8703. Epub 2016 Jun 20.

Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou 311121, China

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http://dx.doi.org/10.1093/nar/gkw549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062966PMC
October 2016

Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer.

Sci Transl Med 2016 10;8(361):361ra140

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaf8127DOI Listing
October 2016

MicroRNAs as potential drug targets for therapeutic intervention in colorectal cancer.

Expert Opin Ther Targets 2015 18;19(12):1705-23. Epub 2015 Jul 18.

a 1 King Abdulaziz University, Center of Excellence in Genomic Medicine Research , Jeddah, Saudi Arabia.

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http://dx.doi.org/10.1517/14728222.2015.1069816DOI Listing
September 2016

Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis.

Cell Rep 2016 08 28;16(6):1614-1628. Epub 2016 Jul 28.

Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981512PMC
August 2016

Organotypic culture in three dimensions prevents radiation-induced transformation in human lung epithelial cells.

Sci Rep 2016 08 19;6:31669. Epub 2016 Aug 19.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, 75235, United States of America.

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http://dx.doi.org/10.1038/srep31669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990973PMC
August 2016

The Metastatic Potential and Chemoresistance of Human Pancreatic Cancer Stem Cells.

PLoS One 2016 9;11(2):e0148807. Epub 2016 Feb 9.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148807PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747523PMC
July 2016

Role of Telomeres and Telomerase in Aging and Cancer.

Authors:
Jerry W Shay

Cancer Discov 2016 06 30;6(6):584-93. Epub 2016 Mar 30.

Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas. Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893918PMC
June 2016

Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies.

Genome Med 2016 06 20;8(1):69. Epub 2016 Jun 20.

Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, 21589, Kingdom of Saudi Arabia.

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http://dx.doi.org/10.1186/s13073-016-0324-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915101PMC
June 2016

Relative Biological Effectiveness of Energetic Heavy Ions for Intestinal Tumorigenesis Shows Male Preponderance and Radiation Type and Energy Dependence in APC(1638N/+) Mice.

Int J Radiat Oncol Biol Phys 2016 May 31;95(1):131-8. Epub 2015 Oct 31.

Department of Biochemistry and Molecular & Cellular Biology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2015.10.057DOI Listing
May 2016

CDDO-Me protects normal lung and breast epithelial cells but not cancer cells from radiation.

PLoS One 2014 23;9(12):e115600. Epub 2014 Dec 23.

Department of Cell Biology, UT Southwestern Medical Center at Dallas, Dallas, Texas, United States of America; Center for Excellence in Genomics Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115600PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275221PMC
April 2016

Comparison of DNA Quantification Methods for Next Generation Sequencing.

Sci Rep 2016 Apr 6;6:24067. Epub 2016 Apr 6.

Department of Cell Biology, 5323 Harry Hines Boulevard, UT Southwestern Medical Center, Dallas, TX 75390-9030, USA.

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http://dx.doi.org/10.1038/srep24067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822169PMC
April 2016

SORBS2 transcription is activated by telomere position effect-over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophy.

Genome Res 2015 Dec 10;25(12):1781-90. Epub 2015 Sep 10.

Department of Cell Biology, UT Southwestern Medical Center, Dallas, Texas 75390, USA; Center for Excellence in Genomics Medicine Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

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http://dx.doi.org/10.1101/gr.190660.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665000PMC
December 2015

Telomerase Repeated Amplification Protocol (TRAP).

Bio Protoc 2015 Nov;5(22)

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, USA;; Center for Excellence in Genomics Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863463PMC
November 2015

Telomere Dysfunction Induced Foci (TIF) Analysis.

Bio Protoc 2015 Nov;5(22)

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, USA; Center for Excellence in Genomics Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972040PMC
November 2015

Telomere Restriction Fragment (TRF) Analysis.

Bio Protoc 2015 Nov;5(22)

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, USA; Center for Excellence in Genomics Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972328PMC
November 2015

A novel telomerase substrate precursor rapidly induces telomere dysfunction in telomerase positive cancer cells but not telomerase silent normal cells.

Oncoscience 2015 22;2(8):693-5. Epub 2015 Aug 22.

University of Texas Southwestern Medical Center, Department of Cell Biology, Dallas, TX, USA ; Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580061PMC
http://dx.doi.org/10.18632/oncoscience.213DOI Listing
October 2015

Peloruside A Inhibits Growth of Human Lung and Breast Tumor Xenografts in an Athymic nu/nu Mouse Model.

Mol Cancer Ther 2015 Aug 8;14(8):1816-23. Epub 2015 Jun 8.

School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0167DOI Listing
August 2015

Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening.

Nat Genet 2015 May 13;47(5):512-7. Epub 2015 Apr 13.

1] Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, USA. [2] Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1038/ng.3278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414891PMC
May 2015

Branching morphogenesis of immortalized human bronchial epithelial cells in three-dimensional culture.

Differentiation 2014 Mar-Apr;87(3-4):119-26. Epub 2014 May 13.

Department of Cell Biology, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA; Center for Excellence in Genomics Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address:

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http://dx.doi.org/10.1016/j.diff.2014.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112006PMC
April 2015

Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs.

Cancer Res 2015 Mar 14;75(5):858-69. Epub 2015 Jan 14.

Department of Radiation Oncology, The Houston Methodist Research Institute, Houston, Texas. Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-2289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351820PMC
March 2015

A primary melanoma and its asynchronous metastasis highlight the role of BRAF, CDKN2A, and TERT.

J Cutan Pathol 2015 Feb 11;42(2):108-17. Epub 2014 Dec 11.

Department of Dermatology, UT Southwestern Medical Center, Dallas, TX, USA; ProPath, Dallas, TX, USA; Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1111/cup.12444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470704PMC
February 2015

Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine.

Cancer Discov 2015 Jan 16;5(1):82-95. Epub 2014 Dec 16.

Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas. Center for Excellence in Genomics Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293221PMC
January 2015

Alternative splicing regulation of telomerase: a new paradigm?

Trends Genet 2014 Oct 26;30(10):430-8. Epub 2014 Aug 26.

Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390-9039, USA; Center for Excellence in Genomics Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address:

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http://dx.doi.org/10.1016/j.tig.2014.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190675PMC
October 2014

Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations.

J Neurooncol 2014 Aug 3;119(1):17-26. Epub 2014 May 3.

Cancer Center, Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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http://dx.doi.org/10.1007/s11060-014-1456-8DOI Listing
August 2014

Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway.

Clin Cancer Res 2014 Aug 6;20(15):4154-66. Epub 2014 Jun 6.

Hamon Center for Therapeutic Oncology Research, Simmons Comprehensive Cancer Center, Pharmacology, and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas

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http://dx.doi.org/10.1158/1078-0432.CCR-13-3292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438754PMC
August 2014

Quantitative telomerase enzyme activity determination using droplet digital PCR with single cell resolution.

Nucleic Acids Res 2014 Jul 26;42(13):e104. Epub 2014 May 26.

Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390-9039, USA

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http://dx.doi.org/10.1093/nar/gku439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117742PMC
July 2014

Cell biology of disease: Telomeropathies: an emerging spectrum disorder.

J Cell Biol 2014 May;205(3):289-99

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.

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http://www.jcb.org/lookup/doi/10.1083/jcb.201401012
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http://dx.doi.org/10.1083/jcb.201401012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018777PMC
May 2014

Inhibition of microRNA-31-5p protects human colonic epithelial cells against ionizing radiation.

Life Sci Space Res (Amst) 2014 Apr 11;1:67-73. Epub 2014 Feb 11.

Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9039, United States. Electronic address:

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http://dx.doi.org/10.1016/j.lssr.2014.02.001DOI Listing
April 2014

Transcriptomic responses of cancerous and noncancerous human colon cells to sulforaphane and selenium.

Chem Res Toxicol 2014 Mar 13;27(3):377-86. Epub 2014 Jan 13.

Department of Biosystems Science and Engineering, ETH Zurich , Basel 4058, Switzerland.

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http://dx.doi.org/10.1021/tx400427tDOI Listing
March 2014

Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer.

Clin Cancer Res 2014 Mar 31;20(6):1610-22. Epub 2014 Jan 31.

Authors' Affiliations: Departments of Cell Biology; Pathology; Molecular Biology; Plastic Surgery; and Clinical Sciences; Simmons Comprehensive Cancer Center; Hamon Center for Therapeutic Oncology; Departments of Internal Medicine; Pharmacology; and Radiation Oncology, UT Southwestern Medical Center, Dallas; Departments of Thoracic/Head and Neck Medical Oncology; and Translational Molecular Pathology; The University of Texas MD Anderson Cancer Center, Houston, Texas; and Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-13-2589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961755PMC
March 2014

Are short telomeres hallmarks of cancer recurrence?

Authors:
Jerry W Shay

Clin Cancer Res 2014 Feb 23;20(4):779-81. Epub 2013 Dec 23.

Author's Affiliation: Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-3198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944321PMC
February 2014

Regulation of human telomerase splicing by RNA:RNA pairing.

Nat Commun 2014 Feb 28;5:3306. Epub 2014 Feb 28.

UT Southwestern Medical Center, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9039, USA.

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http://dx.doi.org/10.1038/ncomms4306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948165PMC
February 2014

A novel molecular pathway for Snail-dependent, SPARC-mediated invasion in non-small cell lung cancer pathogenesis.

Cancer Prev Res (Phila) 2014 Jan 19;7(1):150-60. Epub 2013 Nov 19.

Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, 37-131 Center for Health Sciences, 10833 Le Conte Avenue, Los Angeles, CA 90095.

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http://cancerpreventionresearch.aacrjournals.org/cgi/doi/10.
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http://dx.doi.org/10.1158/1940-6207.CAPR-13-0263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919444PMC
January 2014