Jerry Pelletier

Jerry Pelletier

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Jerry Pelletier

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Correction for Dauber et al., "The Herpes Simplex Virus 1 vhs Protein Enhances Translation of Viral True Late mRNAs and Virus Production in a Cell Type-Dependent Manner".

J Virol 2019 Sep 13;93(17). Epub 2019 Aug 13.

Li Ka Shing Institute of Virology, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2

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http://dx.doi.org/10.1128/JVI.00985-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694810PMC
September 2019

Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors.

Cell Chem Biol 2019 Sep 10. Epub 2019 Sep 10.

Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada; Department of Oncology, McGill University, Montreal, Canada; Rosalind & Morris Goodman Cancer Research Centre, McGill University, Montreal, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.08.008DOI Listing
September 2019

Intercepted Retro-Nazarov Reaction: Syntheses of Amidino-Rocaglate Derivatives and Their Biological Evaluation as eIF4A Inhibitors.

J Am Chem Soc 2019 Aug 30;141(32):12891-12900. Epub 2019 Jul 30.

Department of Chemistry, Center for Molecular Discovery (BU-CMD) , Boston University , 590 Commonwealth Avenue , Boston , Massachusetts 02215 , United States of America.

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http://dx.doi.org/10.1021/jacs.9b06446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693944PMC
August 2019

The Organizing Principles of Eukaryotic Ribosome Recruitment.

Annu Rev Biochem 2019 Jun;88:307-335

Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada; email: ,

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https://www.annualreviews.org/doi/10.1146/annurev-biochem-01
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http://dx.doi.org/10.1146/annurev-biochem-013118-111042DOI Listing
June 2019

Tracing MYC Expression for Small Molecule Discovery.

Cell Chem Biol 2019 May 14;26(5):699-710.e6. Epub 2019 Mar 14.

Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada; The Rosalind and Morris Goodman Cancer Research Center and the Department of Oncology, McGill University, Montreal, QC, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456193004
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http://dx.doi.org/10.1016/j.chembiol.2019.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525070PMC
May 2019

CRISPR/Cas9 Editing to Facilitate and Expand Drug Discovery.

Curr Gene Ther 2017 ;17(4):275-285

Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Canada.

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http://dx.doi.org/10.2174/1566523217666171121164615DOI Listing
April 2019

USP44 is dispensable for normal hematopoietic stem cell function, lymphocyte development, and B-cell-mediated immune response in a mouse model.

Exp Hematol 2019 Apr 9;72:1-8. Epub 2019 Jan 9.

Department of Physiology, McGill University, Montreal, QC, Canada; McGill University Centre on Complex Traits, McGill University, Montreal, QC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2019.01.001DOI Listing
April 2019

O-GlcNAcylation of core components of the translation initiation machinery regulates protein synthesis.

Proc Natl Acad Sci U S A 2019 Apr 2;116(16):7857-7866. Epub 2019 Apr 2.

Ministry of Education Laboratory of Biosystems Homeostasis & Protection, College of Life Sciences, Zhejiang University, 310058 Hangzhou, China;

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http://dx.doi.org/10.1073/pnas.1813026116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475381PMC
April 2019

Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism.

Proc Natl Acad Sci U S A 2019 02 4;116(8):2925-2934. Epub 2019 Feb 4.

Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montréal, QC, Canada H3A 1A3;

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http://dx.doi.org/10.1073/pnas.1815361116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386685PMC
February 2019

Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation.

Sci Rep 2019 Feb 4;9(1):1265. Epub 2019 Feb 4.

Department of Biochemistry, McGill University, Montreal, Québec, H3G 1Y6, Canada.

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http://dx.doi.org/10.1038/s41598-018-37666-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361980PMC
February 2019

Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for Hepatitis C Viral Infection.

J Am Chem Soc 2019 Jan 11;141(3):1312-1323. Epub 2019 Jan 11.

Department of Chemistry, Center for Molecular Discovery (BU-CMD) , Boston University , Boston , Massachusetts 02215 , United States.

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http://pubs.acs.org/doi/10.1021/jacs.8b11477
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http://dx.doi.org/10.1021/jacs.8b11477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6583776PMC
January 2019

A cautionary note on the use of cap analogue affinity resins.

Anal Biochem 2018 11 4;560:24-29. Epub 2018 Sep 4.

Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada; Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada; Department of Oncology, McGill University, Montreal, Quebec, H3G 1Y6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ab.2018.09.001DOI Listing
November 2018

Exploring the Impact of Single-Nucleotide Polymorphisms on Translation.

Front Genet 2018 30;9:507. Epub 2018 Oct 30.

Department of Biochemistry, McGill University, Montreal, QC, Canada.

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https://www.frontiersin.org/article/10.3389/fgene.2018.00507
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http://dx.doi.org/10.3389/fgene.2018.00507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218417PMC
October 2018

Therapeutic Opportunities in Eukaryotic Translation.

Cold Spring Harb Perspect Biol 2018 06 1;10(6). Epub 2018 Jun 1.

Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada.

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http://dx.doi.org/10.1101/cshperspect.a032995DOI Listing
June 2018

Beyond molecular tumor heterogeneity: protein synthesis takes control.

Oncogene 2018 05 21;37(19):2490-2501. Epub 2018 Feb 21.

Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1038/s41388-018-0152-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945578PMC
May 2018

Inducible Genome Editing with Conditional CRISPR/Cas9 Mice.

G3 (Bethesda) 2018 05 4;8(5):1627-1635. Epub 2018 May 4.

Department of Biochemistry, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec

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http://dx.doi.org/10.1534/g3.117.300327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940154PMC
May 2018

eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways.

Sci Rep 2018 05 30;8(1):8414. Epub 2018 May 30.

McGill University, Department of Biochemistry, Rosalind and Morris Goodman Cancer Centre, Montreal, Quebec, Canada.

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http://www.nature.com/articles/s41598-018-26625-9
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http://dx.doi.org/10.1038/s41598-018-26625-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976662PMC
May 2018

Desmocollin 1 is abundantly expressed in atherosclerosis and impairs high-density lipoprotein biogenesis.

Eur Heart J 2018 04;39(14):1194-1202

Research Institute of the McGill University Health Center, 1001 Decarie Blvd, Montreal, Quebec H4A 3J1, Canada.

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http://dx.doi.org/10.1093/eurheartj/ehx340DOI Listing
April 2018

Rocaglates as dual-targeting agents for experimental cerebral malaria.

Proc Natl Acad Sci U S A 2018 03 20;115(10):E2366-E2375. Epub 2018 Feb 20.

Department of Biochemistry, McGill University, Montreal, QC, H3G 0B1 Canada;

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http://dx.doi.org/10.1073/pnas.1713000115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877959PMC
March 2018

Eukaryotic initiation factor 4F-sidestepping resistance mechanisms arising from expression heterogeneity.

Curr Opin Genet Dev 2018 02 21;48:89-96. Epub 2017 Nov 21.

Departments of Biochemistry and Oncology, McGill University, Montreal, Quebec, Canada; Goodman Cancer Research Center, McGill University, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2017.11.002DOI Listing
February 2018

Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response.

Endocrinology 2017 11;158(11):4000-4016

Department of Medicine, McGill University and McGill University Health Centre Research Institute, Montreal, Quebec H4A 3J1, Canada.

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http://dx.doi.org/10.1210/en.2017-00396DOI Listing
November 2017

Isoflavones and Rotenoids from the Leaves of Millettia oblata ssp. teitensis.

J Nat Prod 2017 07 30;80(7):2060-2066. Epub 2017 Jun 30.

Department of Chemistry and Molecular Biology, University of Gothenburg , SE-412 96 Gothenburg, Sweden.

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http://dx.doi.org/10.1021/acs.jnatprod.7b00255DOI Listing
July 2017

A harmine-derived beta-carboline displays anti-cancer effects in vitro by targeting protein synthesis.

Eur J Pharmacol 2017 Jun 18;805:25-35. Epub 2017 Mar 18.

Laboratoire de Cancérologie et Toxicologie Expérimentale, Faculté de Pharmacie, Université Libre de Bruxelles, Brussels, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2017.03.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515283PMC
June 2017

A New Natural Product Analog of Blasticidin S Reveals Cellular Uptake Facilitated by the NorA Multidrug Transporter.

Antimicrob Agents Chemother 2017 06 24;61(6). Epub 2017 May 24.

Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA

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http://dx.doi.org/10.1128/AAC.02635-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444127PMC
June 2017

Data in support of a harmine-derived beta-carboline effects in cancer cells through protein synthesis.

Data Brief 2017 Jun 5;12:546-551. Epub 2017 May 5.

Laboratoire de Cancérologie et Toxicologie Expérimentale, Faculté de Pharmacie, Université Libre de Bruxelles, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.dib.2017.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429240PMC
June 2017

Developing anti-neoplastic biotherapeutics against eIF4F.

Cell Mol Life Sci 2017 05 21;74(9):1681-1692. Epub 2016 Dec 21.

Department of Biochemistry, McGill University, McIntyre Medical Sciences Building, Rm 810, 3655 Drummond St., Montreal, QC, H3G 1Y6, Canada.

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http://link.springer.com/10.1007/s00018-016-2430-8
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http://dx.doi.org/10.1007/s00018-016-2430-8DOI Listing
May 2017

Dependence of p53-deficient cells on the DHX9 DExH-box helicase.

Oncotarget 2017 May;8(19):30908-30921

Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada.

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http://dx.doi.org/10.18632/oncotarget.15889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458177PMC
May 2017

Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations.

Proc Natl Acad Sci U S A 2017 03 1;114(11):E2106-E2115. Epub 2017 Mar 1.

Department of Biochemistry and Groupe de Recherche Axe sur la Structure des Proteines, McGill University, Montreal, QC, Canada H3G 0B1;

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http://dx.doi.org/10.1073/pnas.1612444114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358387PMC
March 2017

Polyoxygenated Cyclohexenes and Other Constituents of Cleistochlamys kirkii Leaves.

J Nat Prod 2017 01 21;80(1):114-125. Epub 2016 Dec 21.

Department of Chemistry and Molecular Biology, University of Gothenburg , SE-412 96 Gothenburg, Sweden.

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http://dx.doi.org/10.1021/acs.jnatprod.6b00759DOI Listing
January 2017

Translation Initiation Factors: Reprogramming Protein Synthesis in Cancer.

Trends Cell Biol 2016 12 15;26(12):918-933. Epub 2016 Jul 15.

Department of Biochemistry, McGill University, Montreal, Quebec, Canada; Gerald Bronfman Department of Oncology, McGill University, Quebec, Canada; The Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2016.06.005DOI Listing
December 2016

A CRISPR/Cas9 Functional Screen Identifies Rare Tumor Suppressors.

Sci Rep 2016 12 16;6:38968. Epub 2016 Dec 16.

Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montreal, Québec, H3G 1Y6, Canada.

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http://dx.doi.org/10.1038/srep38968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159885PMC
December 2016

Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition.

Chemistry 2016 Aug 15;22(34):12006-10. Epub 2016 Jul 15.

Department of Chemistry, Center for Molecular Discovery (BU-CMD), Boston University, 590 Commonwealth Avenue, Boston, MA, 02215, USA.

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http://doi.wiley.com/10.1002/chem.201602953
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http://dx.doi.org/10.1002/chem.201602953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224829PMC
August 2016

Establishment of a Primary Screening Assay for the DHX9 Helicase.

Comb Chem High Throughput Screen 2015 ;18(9):855-61

Rm 810, 3655 Promenade Sir William Osler., McIntyre Medical Sciences Building, Montreal, Quebec, H3G 1Y6, Canada.

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http://dx.doi.org/10.2174/1386207318666151019093433DOI Listing
July 2016

The biology of DHX9 and its potential as a therapeutic target.

Oncotarget 2016 Jul;7(27):42716-42739

Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.18632/oncotarget.8446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173168PMC
July 2016

CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A.

Cell Rep 2016 06 26;15(11):2340-7. Epub 2016 May 26.

Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada; The Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, QC H3G 1Y6, Canada; Department of Oncology, McGill University, Montreal, QC H3G 1Y6, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247163055
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http://dx.doi.org/10.1016/j.celrep.2016.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315212PMC
June 2016

Hippuristanol - A potent steroid inhibitor of eukaryotic initiation factor 4A.

Translation (Austin) 2016 Jan-Jun;4(1):e1137381. Epub 2016 Jan 4.

Department of Biochemistry, McGill University, Montreal, Québec, Canada; The Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Québec, Canada; Department of Oncology, McGill University, Montreal, Québec, Canada.

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http://dx.doi.org/10.1080/21690731.2015.1137381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909409PMC
June 2016

nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs.

Genome Res 2016 05 16;26(5):636-48. Epub 2016 Mar 16.

Lady Davis Institute, SMBD Jewish General Hospital, Montreal, Canada H3T 1E2; Department of Oncology, McGill University, Montreal, Canada H3G 1Y6; Department of Experimental Medicine, McGill University, Montreal, Canada H3G 1Y6; Department of Biochemistry, McGill University, Montreal, Canada H3G 1Y6;

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http://dx.doi.org/10.1101/gr.197566.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864462PMC
May 2016

Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer.

Cell Rep 2016 05 19;15(9):1893-900. Epub 2016 May 19.

Department of Biochemistry, McGill University, Montréal, QC H3G 1Y6, Canada; Goodman Cancer Research Center, McGill University, Montréal, QC H3A 1A3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.04.076DOI Listing
May 2016

Internal translation initiation from HIV-1 transcripts is conferred by a common RNA structure.

Translation (Austin) 2014 29;2(1):e27694. Epub 2014 Jan 29.

Department of Biochemistry and Molecular Genetics and University of Colorado Denver School of Medicine, Aurora, CO USA; Howard Hughes Medical Institute, University of Colorado Denver School of Medicine, Aurora, CO USA.

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http://dx.doi.org/10.4161/trla.27694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705822PMC
January 2016

Translation Inhibition by Rocaglates Is Independent of eIF4E Phosphorylation Status.

Mol Cancer Ther 2016 Jan 19;15(1):136-41. Epub 2015 Nov 19.

Department of Biochemistry, McGill University, Montreal, Québec, Canada. The Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Québec, Canada. Department of Oncology, McGill University, Montreal, Québec, Canada.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707080PMC
January 2016

Protospacer adjacent motif (PAM)-distal sequences engage CRISPR Cas9 DNA target cleavage.

PLoS One 2014 2;9(10):e109213. Epub 2014 Oct 2.

Department of Biochemistry, McGill University, Montreal, Québec, Canada; The Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Québec, Canada; Department of Oncology, McGill University, Montreal, Québec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109213PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183563PMC
December 2015

PAM multiplicity marks genomic target sites as inhibitory to CRISPR-Cas9 editing.

Nat Commun 2015 Dec 8;6:10124. Epub 2015 Dec 8.

Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada.

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http://www.nature.com/articles/ncomms10124
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http://dx.doi.org/10.1038/ncomms10124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686818PMC
December 2015

Differential action of pateamine A on translation of genomic and subgenomic mRNAs from Sindbis virus.

Virology 2015 Oct 5;484:41-50. Epub 2015 Jun 5.

Centro de Biología Molecular Severo Ochoa (CSIC-UAM), C/Nicolás Cabrera, 1, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2015.05.002DOI Listing
October 2015

eIF4AII is dispensable for miRNA-mediated gene silencing.

RNA 2015 Oct 18;21(10):1826-33. Epub 2015 Aug 18.

Department of Biochemistry, McGill University, Montreal, Québec H3G 1Y6, Canada The Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Québec H3G 1Y6, Canada Department of Oncology, McGill University, Montreal, Québec H3G 1Y6, Canada.

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http://dx.doi.org/10.1261/rna.052225.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574758PMC
October 2015

Increased in vitro and in vivo sensitivity of BRCA2-associated pancreatic cancer to the poly(ADP-ribose) polymerase-1/2 inhibitor BMN 673.

Cancer Lett 2015 Aug 9;364(1):8-16. Epub 2015 Apr 9.

Rosalind and Morris Goodman Cancer Research Centre, McGill University, 1160 Pine Ave. West, Montreal, Quebec, Canada H3A 1A3; The Research Institute of the McGill University Health Centre, 1001 Decarie Boulevard, Montreal, Quebec, Canada H4A 3J1. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835150026
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http://dx.doi.org/10.1016/j.canlet.2015.04.003DOI Listing
August 2015

Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing.

Genome Med 2015 Aug 27;7:93. Epub 2015 Aug 27.

Department of Biochemistry, McGill University, Montréal, Québec, H3G 1Y6, Canada.

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http://genomemedicine.com/content/7/1/93
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http://dx.doi.org/10.1186/s13073-015-0215-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550049PMC
August 2015

Targeting the eIF4A RNA helicase as an anti-neoplastic approach.

Biochim Biophys Acta 2015 Jul 16;1849(7):781-91. Epub 2014 Sep 16.

Department of Biochemistry, McGill University, Montreal, Québec, Canada; The Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Québec, Canada; Department of Oncology, McGill University, Montreal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2014.09.006DOI Listing
July 2015

Adapting CRISPR/Cas9 for functional genomics screens.

Methods Enzymol 2014 ;546:193-213

Department of Biochemistry, McGill University, Montreal, Quebec, Canada; Department of Oncology, McGill University, Montreal, Quebec, Canada; The Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-801185-0.00010-6DOI Listing
July 2015

Targeting the translation machinery in cancer.

Nat Rev Drug Discov 2015 Apr 6;14(4):261-78. Epub 2015 Mar 6.

1] Lady Davis Institute for Medical Research, Jewish General Hospital, 3755 Côte-Ste-Catherine Road, Montreal, Quebec, H3T 1E2, Canada. [2] Department of Oncology, McGill University, 546 Pine Avenue West, Montreal, Quebec, H2W 1S6, Canada.

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http://dx.doi.org/10.1038/nrd4505DOI Listing
April 2015

Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm.

J Exp Med 2015 Apr 30;212(4):581-96. Epub 2015 Mar 30.

Institut de Recherches Cliniques de Montréal, Montréal, Québec H2W 1R7, Canada Department of Medicine, Department of Biochemistry, The Rosalind and Morris Goodman Cancer Research Center, and Department of Oncology, McGill University, Montréal, Québec H3A 0G4, Canada Department of Biochemistry and Department of Medicine, Université de Montréal, Montréal, Québec H3T 1J4, Canada Department of Biochemistry and Department of Medicine, Université de Montréal, Montréal, Québec H3T 1J4, Canada

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http://dx.doi.org/10.1084/jem.20141157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387293PMC
April 2015

Targeting the eIF4F translation initiation complex: a critical nexus for cancer development.

Cancer Res 2015 Jan;75(2):250-63

Department of Biochemistry, McGill University, Montreal, Québec, Canada. The Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Québec, Canada.

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http://ruggerolab.ucsf.edu/resources/Publications/Cancer-Res
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-14-2789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299928PMC
January 2015

The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo.

Immunity 2015 Jan 2;42(1):41-54. Epub 2015 Jan 2.

Goodman Cancer Research Centre, McGill University, Montreal, QC, H3G 1Y6, Canada; Department of Physiology, McGill University, Montreal, QC, H3G 1Y6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.12.030DOI Listing
January 2015

Conditional reverse tet-transactivator mouse strains for the efficient induction of TRE-regulated transgenes in mice.

PLoS One 2014 17;9(4):e95236. Epub 2014 Apr 17.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095236PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990578PMC
December 2014

MicroRNAs trigger dissociation of eIF4AI and eIF4AII from target mRNAs in humans.

Mol Cell 2014 Oct;56(1):79-89

Laboratory of Hygienic Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.09.005DOI Listing
October 2014

Regulation of eukaryotic initiation factor 4AII by MyoD during murine myogenic cell differentiation.

PLoS One 2014 23;9(1):e87237. Epub 2014 Jan 23.

Department of Biochemistry, McGill University, Montreal, Quebec, Canada ; The Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Quebec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087237PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900710PMC
September 2014

Translation initiation factor eIF4F modifies the dexamethasone response in multiple myeloma.

Proc Natl Acad Sci U S A 2014 Sep 2;111(37):13421-6. Epub 2014 Sep 2.

Departments of Biochemistry, The Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, QC, Canada H3G 1Y6; Oncology, and

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http://dx.doi.org/10.1073/pnas.1402650111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169926PMC
September 2014

Suppression of the DHX9 helicase induces premature senescence in human diploid fibroblasts in a p53-dependent manner.

J Biol Chem 2014 Aug 2;289(33):22798-814. Epub 2014 Jul 2.

From the Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada, the Department of Oncology, The Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Quebec H3A 1A3, Canada, and

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http://dx.doi.org/10.1074/jbc.M114.568535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132785PMC
August 2014

Single-molecule kinetics of the eukaryotic initiation factor 4AI upon RNA unwinding.

Structure 2014 Jul 5;22(7):941-8. Epub 2014 Jun 5.

Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA; Faculty of Biomedical Engineering, The Technion, Haifa 32000, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.str.2014.04.014DOI Listing
July 2014

Synthesis of the antiproliferative agent hippuristanol and its analogues from hydrocortisone via Hg(II)-catalyzed spiroketalization: structure-activity relationship.

J Med Chem 2014 Mar 11;57(6):2511-23. Epub 2014 Mar 11.

Département de Chimie, Faculté des Sciences et de Génie, Pavillon Alexandre-Vachon, Université Laval , 1045, Avenue de la Médecine, Ville de Québec, Québec, G1V 0A6, Canada.

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http://dx.doi.org/10.1021/jm401799jDOI Listing
March 2014

Perturbations of RNA helicases in cancer.

Wiley Interdiscip Rev RNA 2013 Jul-Aug;4(4):333-49. Epub 2013 May 8.

Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

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http://doi.wiley.com/10.1002/wrna.1163
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http://dx.doi.org/10.1002/wrna.1163DOI Listing
January 2014

Repurposing CRISPR/Cas9 for in situ functional assays.

Genes Dev 2013 Dec;27(23):2602-14

Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6 Canada,;

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http://dx.doi.org/10.1101/gad.227132.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861673PMC
December 2013

Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia.

BMC Pharmacol Toxicol 2013 Nov 13;14:58. Epub 2013 Nov 13.

Departments of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada.

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http://dx.doi.org/10.1186/2050-6511-14-58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225821PMC
November 2013

Throwing a monkey wrench in the motor: targeting DExH/D box proteins with small molecule inhibitors.

Biochim Biophys Acta 2013 Aug 4;1829(8):894-903. Epub 2013 Feb 4.

Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.bbagrm.2013.01.008DOI Listing
August 2013

The von Hippel-Lindau protein pVHL inhibits ribosome biogenesis and protein synthesis.

J Biol Chem 2013 Jun 23;288(23):16588-97. Epub 2013 Apr 23.

Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1074/jbc.M113.455121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675594PMC
June 2013

Requirements for eIF4A and eIF2 during translation of Sindbis virus subgenomic mRNA in vertebrate and invertebrate host cells.

Cell Microbiol 2013 May 20;15(5):823-40. Epub 2012 Dec 20.

Centro de Biología Molecular Severo Ochoa (CSIC-UAM), C/Nicolás Cabrera, 1, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.

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http://dx.doi.org/10.1111/cmi.12079DOI Listing
May 2013

Minor C-geranylated flavanones from Paulownia tomentosa fruits with MRSA antibacterial activity.

Phytochemistry 2013 May 1;89:104-13. Epub 2013 Mar 1.

Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého 1-3, CZ-612 42 Brno, Czech Republic.

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http://dx.doi.org/10.1016/j.phytochem.2013.01.002DOI Listing
May 2013

Inhibitors of translation targeting eukaryotic translation initiation factor 4A.

Methods Enzymol 2012 ;511:437-61

Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/B978-0-12-396546-2.00020-6DOI Listing
October 2012

Tumor progression and metastasis: role of translational deregulation.

Anticancer Res 2012 Aug;32(8):3077-84

Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

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August 2012

A cellular response linking eIF4AI activity to eIF4AII transcription.

RNA 2012 Jul 15;18(7):1373-84. Epub 2012 May 15.

Department of Biochemistry, McGill University, Montreal, Quebec H3G1Y6, Canada.

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http://dx.doi.org/10.1261/rna.033209.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383968PMC
July 2012

The translation inhibitor pateamine A prevents cachexia-induced muscle wasting in mice.

Nat Commun 2012 Jun 12;3:896. Epub 2012 Jun 12.

Department of Biochemistry, Rosalind and Morris Goodman Cancer Center, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/ncomms1899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621420PMC
June 2012

Emerging therapeutics targeting mRNA translation.

Cold Spring Harb Perspect Biol 2012 Apr 1;4(4):a012377. Epub 2012 Apr 1.

Department of Biochemistry and McGill University, Montréal, Québec H3G 1Y6, Canada.

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http://dx.doi.org/10.1101/cshperspect.a012377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312682PMC
April 2012

Synthesis of rocaglamide hydroxamates and related compounds as eukaryotic translation inhibitors: synthetic and biological studies.

J Med Chem 2012 Jan 19;55(1):558-62. Epub 2011 Dec 19.

Department of Chemistry, Center for Chemical Methodology and Library Development (CMLD-BU), Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.

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http://dx.doi.org/10.1021/jm201263kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263355PMC
January 2012

Eukaryotic initiation factor 4F: a vulnerability of tumor cells.

Future Med Chem 2012 Jan;4(1):19-31

Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada.

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http://www.future-science.com/doi/10.4155/fmc.11.150
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http://dx.doi.org/10.4155/fmc.11.150DOI Listing
January 2012

Inhibiting mitochondrial-dependent proteolysis of Mcl-1 promotes resistance to DNA damage.

Cell Cycle 2012 Jan 1;11(1):88-98. Epub 2012 Jan 1.

Department of Biochemistry, McGill University, Montréal, QC, Canada.

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http://dx.doi.org/10.4161/cc.11.1.18408DOI Listing
January 2012

The human insulin mRNA is partly translated via a cap- and eIF4A-independent mechanism.

Biochem Biophys Res Commun 2011 Sep 16;412(4):693-8. Epub 2011 Aug 16.

Department of Medical Cell Biology, Uppsala University, Biomedicum, Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.bbrc.2011.08.030DOI Listing
September 2011

Structural conservation of druggable hot spots in protein-protein interfaces.

Proc Natl Acad Sci U S A 2011 Aug 1;108(33):13528-33. Epub 2011 Aug 1.

Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.

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http://dx.doi.org/10.1073/pnas.1101835108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158149PMC
August 2011