Jerry Kaplan

Jerry Kaplan

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The mitochondrial iron exporter genes MMT1 and MMT2 in yeast are transcriptionally regulated by Aft1 and Yap1.

J Biol Chem 2020 Jan 2. Epub 2020 Jan 2.

Department of Pathology, University of Utah School of Medicine, United States.

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http://dx.doi.org/10.1074/jbc.RA119.011154DOI Listing
January 2020

The glucose sensor Snf1 and the transcription factors Msn2 and Msn4 regulate transcription of the vacuolar iron importer gene and iron resistance in yeast.

J Biol Chem 2017 09 31;292(37):15577-15586. Epub 2017 Jul 31.

From the Department of Pathology, Division of Microbiology and Immunology, School of Medicine, University of Utah, Salt Lake City, Utah 84132-2501

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http://dx.doi.org/10.1074/jbc.M117.802504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602413PMC
September 2017

Two novel mutations in TMPRSS6 associated with iron-refractory iron deficiency anemia in a mother and child.

Blood Cells Mol Dis 2017 06 9;65:38-40. Epub 2017 Apr 9.

Center for Iron and Heme Disorders, University of Utah, and Division of Hematology/Oncology, Department of Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA.

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http://dx.doi.org/10.1016/j.bcmd.2017.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656052PMC
June 2017

Muscle specific iron deficiency has systemic consequences.

EBioMedicine 2015 Nov 5;2(11):1582-3. Epub 2015 Oct 5.

Department of Pathology, School of Medicine University of Utah, Salt Lake City, Utah.

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http://dx.doi.org/10.1016/j.ebiom.2015.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740307PMC
November 2015

Expression of the yeast cation diffusion facilitators Mmt1 and Mmt2 affects mitochondrial and cellular iron homeostasis: evidence for mitochondrial iron export.

J Biol Chem 2014 Jun 5;289(24):17132-41. Epub 2014 May 5.

From the Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132

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http://dx.doi.org/10.1074/jbc.M114.574723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059154PMC
June 2014

Leishmania-mediated inhibition of iron export promotes parasite replication in macrophages.

PLoS Pathog 2014 Jan 30;10(1):e1003901. Epub 2014 Jan 30.

Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907422PMC
January 2014

The essential nature of iron usage and regulation.

Curr Biol 2013 11 18;23(22):2325. Epub 2013 Nov 18.

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http://dx.doi.org/10.1016/j.cub.2013.10.059DOI Listing
November 2013

The essential nature of iron usage and regulation.

Curr Biol 2013 Aug;23(15):R642-6

Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1016/j.cub.2013.05.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928970PMC
August 2013

Murine macrophages response to iron.

J Proteomics 2012 Dec 23;76 Spec No.:10-27. Epub 2012 Jul 23.

University of Verona, Department of Biotechnology, Strada Le Grazie 15, 37134 Verona, Italy.

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http://dx.doi.org/10.1016/j.jprot.2012.07.018DOI Listing
December 2012

A role for iron-sulfur clusters in the regulation of transcription factor Yap5-dependent high iron transcriptional responses in yeast.

J Biol Chem 2012 Oct 22;287(42):35709-21. Epub 2012 Aug 22.

Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA.

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http://dx.doi.org/10.1074/jbc.M112.395533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471690PMC
October 2012

Ferroportin-mediated iron transport: expression and regulation.

Biochim Biophys Acta 2012 Sep 13;1823(9):1426-33. Epub 2012 Mar 13.

Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA.

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http://dx.doi.org/10.1016/j.bbamcr.2012.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718258PMC
September 2012

Mon1a protein acts in trafficking through the secretory apparatus.

J Biol Chem 2012 Jul 4;287(30):25577-88. Epub 2012 Jun 4.

Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA.

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http://dx.doi.org/10.1074/jbc.M112.354043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408209PMC
July 2012

Regulation of ribonucleotide reductase during iron limitation.

Mol Cell 2011 Dec;44(5):683-4

Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1016/j.molcel.2011.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259026PMC
December 2011

Yap5 protein-regulated transcription of the TYW1 gene protects yeast from high iron toxicity.

J Biol Chem 2011 Nov 14;286(44):38488-97. Epub 2011 Sep 14.

Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA.

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http://dx.doi.org/10.1074/jbc.M111.286666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207407PMC
November 2011

The role of ubiquitination in hepcidin-independent and hepcidin-dependent degradation of ferroportin.

Cell Metab 2011 Nov 20;14(5):635-46. Epub 2011 Oct 20.

Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1016/j.cmet.2011.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229915PMC
November 2011

Hepcidin and ferroportin: the new players in iron metabolism.

Semin Liver Dis 2011 Aug 7;31(3):272-9. Epub 2011 Sep 7.

Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, Utah, USA.

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http://dx.doi.org/10.1055/s-0031-1286058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706197PMC
August 2011

Abnormal mitoferrin-1 expression in patients with erythropoietic protoporphyria.

Exp Hematol 2011 Jul 11;39(7):784-94. Epub 2011 May 11.

Department of Medicine and Liver Center, University of Alabama at Birmingham, Birmingham, Alabama 35294-0005, USA.

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http://dx.doi.org/10.1016/j.exphem.2011.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143264PMC
July 2011

Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis.

Mol Cell Biol 2011 Apr 19;31(7):1344-56. Epub 2011 Jan 19.

Department of Medicine, Division of Hematology, Brigham and Women’s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.01010-10
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http://dx.doi.org/10.1128/MCB.01010-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135305PMC
April 2011

Genetic and biochemical analysis of high iron toxicity in yeast: iron toxicity is due to the accumulation of cytosolic iron and occurs under both aerobic and anaerobic conditions.

J Biol Chem 2011 Feb 29;286(5):3851-62. Epub 2010 Nov 29.

Department of Pharmacology, School of Medicine, University of California at San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.M110.190959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030386PMC
February 2011

Decoupling ferritin synthesis from free cytosolic iron results in ferritin secretion.

Cell Metab 2011 Jan;13(1):57-67

Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84132-2501, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S155041311000445
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http://dx.doi.org/10.1016/j.cmet.2010.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035985PMC
January 2011

The molecular basis of iron overload disorders and iron-linked anemias.

Int J Hematol 2011 Jan 7;93(1):14-20. Epub 2011 Jan 7.

Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84312, USA.

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http://link.springer.com/10.1007/s12185-010-0760-0
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http://dx.doi.org/10.1007/s12185-010-0760-0DOI Listing
January 2011

Induction of FPN1 transcription by MTF-1 reveals a role for ferroportin in transition metal efflux.

Blood 2010 Nov 5;116(22):4657-64. Epub 2010 Aug 5.

Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT, USA.

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http://dx.doi.org/10.1182/blood-2010-04-278614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996121PMC
November 2010

Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice.

J Clin Invest 2010 Jul 7;120(7):2395-405. Epub 2010 Jun 7.

Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA.

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http://dx.doi.org/10.1172/JCI42011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898601PMC
July 2010

Human mutation D157G in ferroportin leads to hepcidin-independent binding of Jak2 and ferroportin down-regulation.

Blood 2010 Apr 2;115(14):2956-9. Epub 2010 Feb 2.

Division of Hematology, Department of Medicine, School of Medicine, University of Utah, Salt Lake City, USA.

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http://dx.doi.org/10.1182/blood-2009-10-251306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854436PMC
April 2010

Genetic dissection of a mitochondria-vacuole signaling pathway in yeast reveals a link between chronic oxidative stress and vacuolar iron transport.

J Biol Chem 2010 Apr 5;285(14):10232-42. Epub 2010 Feb 5.

Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA.

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http://dx.doi.org/10.1074/jbc.M109.096859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856228PMC
April 2010

Autophagy, ferritin and iron chelation.

Autophagy 2010 Jan 10;6(1):157. Epub 2010 Jan 10.

Department of Internal Medicine, University of Utah, School of Medicine, Salt Lake City, UT, USA.

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http://dx.doi.org/10.4161/auto.6.1.10587DOI Listing
January 2010

On the mechanism of iron sensing by IRP2: new players, new paradigms.

Nat Chem Biol 2009 Dec;5(12):874-875

Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.

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http://dx.doi.org/10.1038/nchembio.261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503334PMC
December 2009

Specific iron chelators determine the route of ferritin degradation.

Blood 2009 Nov 11;114(20):4546-51. Epub 2009 Aug 11.

Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1182/blood-2009-05-224188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777130PMC
November 2009

Hepcidin is elevated in mice injected with Mycoplasma arthritidis.

J Inflamm (Lond) 2009 Nov 24;6:33. Epub 2009 Nov 24.

Division of Hematology, Department of Internal Medicine, University of Utah, School of Medicine, 30 North 1900 East, Salt Lake City, 84132, Utah, USA.

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http://dx.doi.org/10.1186/1476-9255-6-33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791099PMC
November 2009

Iron acquisition and transcriptional regulation.

Chem Rev 2009 Oct;109(10):4536-52

Department of Biochemistry and Biophysics, Texas A&M University, USA.

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http://pubs.acs.org/doi/abs/10.1021/cr9001676
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http://dx.doi.org/10.1021/cr9001676DOI Listing
October 2009

A new wrinkle in the fold: hepcidin links inflammation to the unfolded protein response.

Cell Metab 2009 Oct;10(4):245-6

Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1016/j.cmet.2009.09.005DOI Listing
October 2009

The ferroportin metal efflux proteins function in iron and cobalt homeostasis in Arabidopsis.

Plant Cell 2009 Oct 27;21(10):3326-38. Epub 2009 Oct 27.

Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, USA.

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http://dx.doi.org/10.1105/tpc.109.069401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782287PMC
October 2009

Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria.

Proc Natl Acad Sci U S A 2009 Sep 4;106(38):16263-8. Epub 2009 Sep 4.

Department of Medicine, Hematology Division, Brigham and Women's Hospital, and Hematology-Oncology Division, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0904519106
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http://dx.doi.org/10.1073/pnas.0904519106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752562PMC
September 2009

Gain-of-function mutations identify amino acids within transmembrane domains of the yeast vacuolar transporter Zrc1 that determine metal specificity.

Biochem J 2009 Aug 13;422(2):273-83. Epub 2009 Aug 13.

Department of Pathology, Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1042/BJ20090853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378827PMC
August 2009

Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2.

Proc Natl Acad Sci U S A 2009 Mar 20;106(10):3800-5. Epub 2009 Feb 20.

Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132-2501, USA.

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http://dx.doi.org/10.1073/pnas.0900453106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656160PMC
March 2009

Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2.

Mol Cell Biol 2009 Feb 15;29(4):1007-16. Epub 2008 Dec 15.

Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.01685-08
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http://dx.doi.org/10.1128/MCB.01685-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643804PMC
February 2009

Serum ferritin regulates blood vessel formation: a role beyond iron storage.

Proc Natl Acad Sci U S A 2009 Feb 4;106(6):1683-4. Epub 2009 Feb 4.

Department of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT 84132-2501, USA.

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http://www.pnas.org/lookup/doi/10.1073/pnas.0813318106
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http://dx.doi.org/10.1073/pnas.0813318106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644094PMC
February 2009

A Tf-independent iron transport system required for organogenesis.

Dev Cell 2009 Jan;16(1):3-4

Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1016/j.devcel.2008.12.013DOI Listing
January 2009

A single amino acid change in the yeast vacuolar metal transporters ZRC1 and COT1 alters their substrate specificity.

J Biol Chem 2008 Dec 16;283(49):33865-73. Epub 2008 Oct 16.

Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA.

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http://dx.doi.org/10.1074/jbc.M804377200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590694PMC
December 2008

The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin.

Cell Metab 2008 Dec 30;8(6):502-11. Epub 2008 Oct 30.

Vita-Salute San Raffaele University, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele, Milan, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S15504131080031
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http://dx.doi.org/10.1016/j.cmet.2008.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648389PMC
December 2008

Control of parasitophorous vacuole expansion by LYST/Beige restricts the intracellular growth of Leishmania amazonensis.

PLoS Pathog 2008 Oct 17;4(10):e1000179. Epub 2008 Oct 17.

Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1000179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562527PMC
October 2008

Iron depletion limits intracellular bacterial growth in macrophages.

Blood 2008 Aug 27;112(3):866-74. Epub 2008 Mar 27.

Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA.

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http://dx.doi.org/10.1182/blood-2007-12-126854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481528PMC
August 2008

Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis.

J Biol Chem 2008 Apr 15;283(16):10276-86. Epub 2008 Feb 15.

Department of Pathology and Departments of Biochemistry and Medicine, School of Medicine, University of Utah, Salt Lake City Utah 84132, USA.

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http://dx.doi.org/10.1074/jbc.M801160200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447656PMC
April 2008

Some vertebrates go with the GLO.

Cell 2008 Mar;132(6):921-2

Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1016/j.cell.2008.03.005DOI Listing
March 2008

Yap5 is an iron-responsive transcriptional activator that regulates vacuolar iron storage in yeast.

Mol Cell Biol 2008 Feb 10;28(4):1326-37. Epub 2007 Dec 10.

Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1128/MCB.01219-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258748PMC
February 2008

Regulation of iron acquisition and storage: consequences for iron-linked disorders.

Nat Rev Mol Cell Biol 2008 Jan;9(1):72-81

Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA.

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http://dx.doi.org/10.1038/nrm2295DOI Listing
January 2008

Chediak-Higashi syndrome.

Curr Opin Hematol 2008 Jan;15(1):22-9

Department of Pathology, University of Utah School of Medicine, 30 N. 1900 E., Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1097/MOH.0b013e3282f2bcceDOI Listing
January 2008

Zebrafish as a model for defining the functional impact of mammalian ferroportin mutations.

Blood 2007 Nov 28;110(10):3780-3. Epub 2007 Aug 28.

Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2007-07-10
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http://dx.doi.org/10.1182/blood-2007-07-100248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077323PMC
November 2007

Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice.

Nat Genet 2007 Aug 15;39(8):1025-32. Epub 2007 Jul 15.

Division of Hematology/Oncology, Children's Hospital Boston, Boston, Massachusetts, 02115 USA.

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http://dx.doi.org/10.1038/ng2059DOI Listing
August 2007

The WD repeat protein FAN regulates lysosome size independent from abnormal downregulation/membrane recruitment of protein kinase C.

Exp Cell Res 2007 Jul 24;313(12):2703-18. Epub 2007 Apr 24.

Institut für Immunologie, Universitätsklinikum Schleswig-Holstein Campus Kiel, Michaelisstr. 5, 24105 Kiel, Germany.

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http://dx.doi.org/10.1016/j.yexcr.2007.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988431PMC
July 2007

Hepcidin regulation: ironing out the details.

J Clin Invest 2007 Jul;117(7):1755-8

Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84106, USA.

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http://dx.doi.org/10.1172/JCI32701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904333PMC
July 2007

Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin.

EMBO J 2007 Jun 31;26(12):2823-31. Epub 2007 May 31.

Department of Pathology, School of Medicine, University of Utah, 50 North Medical Drive, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1038/sj.emboj.7601735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1894773PMC
June 2007

The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease.

Blood 2007 May 8;109(10):4174-80. Epub 2007 Feb 8.

Howard Hughes Medical Institute, Department of Pediatrics, Section of Developmental Biology, University of Colorado at Denver and Health Sciences Center, Aurora.

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http://dx.doi.org/10.1182/blood-2007-01-066068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885502PMC
May 2007

Evidence for the multimeric structure of ferroportin.

Blood 2007 Mar 31;109(5):2205-9. Epub 2006 Oct 31.

Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA.

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http://www.bloodjournal.org/content/109/5/2205.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-06-03
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http://dx.doi.org/10.1182/blood-2006-06-032516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1801059PMC
March 2007

Localization of iron in Arabidopsis seed requires the vacuolar membrane transporter VIT1.

Science 2006 Nov 2;314(5803):1295-8. Epub 2006 Nov 2.

Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1126/science.1132563DOI Listing
November 2006

Ferroportin-mediated mobilization of ferritin iron precedes ferritin degradation by the proteasome.

EMBO J 2006 Nov 2;25(22):5396-404. Epub 2006 Nov 2.

Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA.

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http://dx.doi.org/10.1038/sj.emboj.7601409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636618PMC
November 2006

PKR1 encodes an assembly factor for the yeast V-type ATPase.

J Biol Chem 2006 Oct 22;281(42):32025-35. Epub 2006 Aug 22.

Division of Immunology and Cell Biology, Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132-2501, USA.

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http://dx.doi.org/10.1074/jbc.M606451200DOI Listing
October 2006

Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release.

J Virol 2006 Oct;80(19):9465-80

Department of Biochemistry, 15 N. Medical Drive East, Room 4100, University of Utah School of Medicine, Salt Lake City, UT 84112-5650, USA.

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http://dx.doi.org/10.1128/JVI.01049-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1617254PMC
October 2006

YKE4 (YIL023C) encodes a bidirectional zinc transporter in the endoplasmic reticulum of Saccharomyces cerevisiae.

J Biol Chem 2006 Aug 7;281(32):22566-74. Epub 2006 Jun 7.

Division of Cell Biology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.

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August 2006

Molecular and clinical correlates in iron overload associated with mutations in ferroportin.

Haematologica 2006 Aug;91(8):1092-5

Dipartimento di Scienze Microbiologiche Genetiche e Molecolari, Università di Messina, 98166 Messina, Italia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718284PMC
August 2006

Iron-dependent metabolic remodeling in S. cerevisiae.

Biochim Biophys Acta 2006 Jul 5;1763(7):646-51. Epub 2006 Apr 5.

Department of Pathology, School of Medicine University of Utah, Salt Lake City, UT 84132-2501, USA.

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http://dx.doi.org/10.1016/j.bbamcr.2006.03.008DOI Listing
July 2006

Grey, a novel mutation in the murine Lyst gene, causes the beige phenotype by skipping of exon 25.

Mamm Genome 2006 Mar 3;17(3):203-10. Epub 2006 Mar 3.

Anatomisches Institut, Universität Bonn, Germany.

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http://dx.doi.org/10.1007/s00335-005-0015-1DOI Listing
March 2006

Recruitment of Tup1p and Cti6p regulates heme-deficient expression of Aft1p target genes.

EMBO J 2006 Feb 26;25(3):512-21. Epub 2006 Jan 26.

Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132-2501, USA.

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http://dx.doi.org/10.1038/sj.emboj.7600961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1383541PMC
February 2006

The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study.

Blood 2006 Jan 1;107(1):328-33. Epub 2005 Sep 1.

Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1690, USA.

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http://dx.doi.org/10.1182/blood-2005-05-2049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895343PMC
January 2006

Iron overload due to mutations in ferroportin.

Haematologica 2006 Jan;91(1):92-5

Dipartimento di Scienze Microbiologiche Genetiche e Molecolari, Università di Messina, Messina, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718253PMC
January 2006

Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis.

Nature 2005 Aug;436(7053):1035-39

Stem Cell Program and Division Hematology/Oncology Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature03887DOI Listing
August 2005

Regulatory oversight of the iron trade: posttranscriptional regulation in yeast.

Cell Metab 2005 Jul;2(1):4-6

Department of Structural Biology, Stanford University, Palo Alto, CA 94305, USA.

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http://dx.doi.org/10.1016/j.cmet.2005.06.008DOI Listing
July 2005

Post-transcriptional regulation of the yeast high affinity iron transport system.

J Biol Chem 2005 Jun 7;280(23):22181-90. Epub 2005 Apr 7.

Dipartimento di Scienze Microbiologiche Genetiche e Molecolari, Università di Messina, Salita Sperone 31, I-98166 Villaggio S. Agata, Messina I-98166, Italy.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M414663200
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June 2005

The molecular basis of ferroportin-linked hemochromatosis.

Proc Natl Acad Sci U S A 2005 Jun 13;102(25):8955-60. Epub 2005 Jun 13.

Dipartimento di Scienze Microbiologiche Genetiche e Molecolari, Università di Messina, 98166 Messina, Italy.

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http://dx.doi.org/10.1073/pnas.0503804102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1157058PMC
June 2005

The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells.

J Biol Chem 2005 Mar 11;280(11):10548-55. Epub 2005 Jan 11.

University of Utah Health Sciences Center, Department of Pathology, Salt Lake City, Utah 84132, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M413734200
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March 2005

Strokes after intravenous gamma globulin: thrombotic phenomenon in patients with risk factors or just coincidence?

Am J Hematol 2005 Mar;78(3):216-20

Comprehensive Cancer Center, New York Medical College, Our Lady of Mercy Medical Center, Bronx, New York 10466, USA.

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http://doi.wiley.com/10.1002/ajh.20287
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March 2005

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization.

Science 2004 Dec 28;306(5704):2090-3. Epub 2004 Oct 28.

Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1126/science.1104742DOI Listing
December 2004

Defective lysosomal exocytosis and plasma membrane repair in Chediak-Higashi/beige cells.

Proc Natl Acad Sci U S A 2004 Nov 22;101(48):16795-800. Epub 2004 Nov 22.

Section of Microbial Pathogenesis and Department of Cell Biology, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.

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http://dx.doi.org/10.1073/pnas.0405905101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC534728PMC
November 2004

Bph1p, the Saccharomyces cerevisiae homologue of CHS1/beige, functions in cell wall formation and protein sorting.

Traffic 2004 Sep;5(9):700-10

Department of Pathology, Division of Cell Biology and Immunology, University of Utah Health Science Center, Salt Lake City, Utah 84132, USA.

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http://dx.doi.org/10.1111/j.1600-0854.2004.00213.xDOI Listing
September 2004

A mitochondrial-vacuolar signaling pathway in yeast that affects iron and copper metabolism.

J Biol Chem 2004 Aug 25;279(32):33653-61. Epub 2004 May 25.

Division of Immunology and Cell Biology, Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA.

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August 2004

Transcription of the yeast iron regulon does not respond directly to iron but rather to iron-sulfur cluster biosynthesis.

J Biol Chem 2004 Jul 28;279(28):29513-8. Epub 2004 Apr 28.

Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA.

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http://dx.doi.org/10.1074/jbc.M403209200DOI Listing
July 2004

A fungal multicopper oxidase restores iron homeostasis in aceruloplasminemia.

Blood 2004 Jun 22;103(12):4672-3. Epub 2004 Jan 22.

Department of Anesthesiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1182/blood-2003-11-4060DOI Listing
June 2004

Characterization of Vta1p, a class E Vps protein in Saccharomyces cerevisiae.

J Biol Chem 2004 Mar 29;279(12):10982-90. Epub 2003 Dec 29.

Department of Pathology, Division of Cell Biology and Immunology, University of Utah Health Science Center, Salt Lake City, Utah 84132-2501, USA.

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March 2004

Genome-wide analysis of iron-dependent growth reveals a novel yeast gene required for vacuolar acidification.

J Biol Chem 2004 Feb 21;279(6):4322-9. Epub 2003 Nov 21.

Division of Immunology and Cell Biology, Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA.

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February 2004