Jeroen P Roose

Jeroen P Roose

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Jeroen P Roose

Jeroen P Roose

Publications by authors named "Jeroen P Roose"

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39Publications

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Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases.

Science 2019 10 19;366(6461):109-115. Epub 2019 Sep 19.

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1126/science.aay0543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007921PMC
October 2019

mTOR and other effector kinase signals that impact T cell function and activity.

Immunol Rev 2019 09;291(1):134-153

Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1111/imr.12796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697425PMC
September 2019

Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer.

Cancers (Basel) 2019 Sep 24;11(10). Epub 2019 Sep 24.

Department of Anatomy, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.3390/cancers11101423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826786PMC
September 2019

Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation.

Sci Signal 2019 07 23;12(591). Epub 2019 Jul 23.

Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1126/scisignal.aao0736DOI Listing
July 2019

Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells.

Cell Rep 2019 05;27(6):1858-1874.e6

Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.04.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593126PMC
May 2019

Tonic Signals: Why Do Lymphocytes Bother?

Trends Immunol 2017 11 25;38(11):844-857. Epub 2017 Jul 25.

Department of Anatomy, School of Medicine, University of California, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.it.2017.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669999PMC
November 2017

RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma.

Cancer Cell 2017 05;31(5):685-696.e6

Departments of Dermatology and Pathology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499527PMC
May 2017

Distinct oncogenic Ras signals characterized by profound differences in flux through the RasGDP/RasGTP cycle.

Small GTPases 2017 01 9;8(1):20-25. Epub 2016 May 9.

a Department of Anatomy , University of California San Francisco , San Francisco , CA , USA.

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http://dx.doi.org/10.1080/21541248.2016.1187323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331899PMC
January 2017

Lost GRP on cytotoxicity?

Authors:
Jeroen P Roose

Nat Immunol 2016 11;17(12):1339-1340

Department of Anatomy, University of California San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1038/ni.3620DOI Listing
November 2016

One-way membrane trafficking of SOS in receptor-triggered Ras activation.

Nat Struct Mol Biol 2016 09 8;23(9):838-46. Epub 2016 Aug 8.

Department of Chemistry, University of California, Berkeley, Berkeley, California, USA.

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http://dx.doi.org/10.1038/nsmb.3275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016256PMC
September 2016

Flavors of EGFR-Ras signals impacting intestinal homeostasis.

Cell Cycle 2015 ;14(20):3205-6

a Department of Anatomy ; University of California, San Francisco ; San Francisco , CA USA.

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http://dx.doi.org/10.1080/15384101.2015.1084203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825600PMC
August 2016

Unexpected insights for anti-EGFR cancer therapy.

Oncotarget 2015 Aug;6(22):18746-7

Department of Anatomy, University of California, San Francisco, San Francisco, California, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662453PMC
http://dx.doi.org/10.18632/oncotarget.5115DOI Listing
August 2015

RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.

Nat Cell Biol 2015 Jun 25;17(6):804-15. Epub 2015 May 25.

Department of Anatomy, University of California, San Francisco, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/ncb3175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652934PMC
June 2015

RasGRP Ras guanine nucleotide exchange factors in cancer.

Front Biol (Beijing) 2013 Oct;8(5):508-532

Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1007/s11515-013-1276-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987922PMC
October 2013

Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells.

Front Immunol 2013 Sep 4;4:239. Epub 2013 Sep 4.

Department of Anatomy, University of California San Francisco , San Francisco, CA , USA.

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http://dx.doi.org/10.3389/fimmu.2013.00239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762125PMC
September 2013

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1.

Elife 2013 Jul 30;2:e00813. Epub 2013 Jul 30.

Department of Molecular and Cell Biology , University of California, Berkeley , Berkeley , United States ; California Institute for Quantitative Biosciences , University of California, Berkeley , Berkeley , United States.

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http://dx.doi.org/10.7554/eLife.00813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728621PMC
July 2013

Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS.

Mol Cell Biol 2013 Jun 15;33(12):2470-84. Epub 2013 Apr 15.

Department of Anatomy, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1128/MCB.01593-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700092PMC
June 2013

The membrane environment can promote or suppress bistability in cell signaling networks.

J Phys Chem B 2012 Mar 13;116(11):3630-40. Epub 2012 Mar 13.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1021/jp2102385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321252PMC
March 2012

Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression.

PLoS One 2011 26;6(9):e25540. Epub 2011 Sep 26.

Department of Anatomy, University of California San Francisco, San Francisco, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025540PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180458PMC
February 2012

STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development.

Nat Immunol 2011 May 27;12(5):425-33. Epub 2011 Mar 27.

Department of Medicine, Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, University of California at San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1038/ni.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623929PMC
May 2011

Origin of the sharp boundary that discriminates positive and negative selection of thymocytes.

Proc Natl Acad Sci U S A 2009 Jan 19;106(2):528-33. Epub 2008 Dec 19.

Departments of Chemical Engineering, Chemistry, and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.0805981105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626737PMC
January 2009

Digital signaling and hysteresis characterize ras activation in lymphoid cells.

Cell 2009 Jan;136(2):337-51

Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.cell.2008.11.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662698PMC
January 2009

Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes.

Mol Cell Biol 2007 Apr 5;27(7):2732-45. Epub 2007 Feb 5.

Department of Medicine, University of California-San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0795, USA.

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http://dx.doi.org/10.1128/MCB.01882-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899892PMC
April 2007

A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.

Mol Cell Biol 2005 Jun;25(11):4426-41

Department of Medicine, UCSF, 533 Parnassus Avenue, Room U-330, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1128/MCB.25.11.4426-4441.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1140631PMC
June 2005

Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases.

Mol Cell Biol 2005 Jun;25(12):4924-33

Department of Medicine, The Rosalind Russell Medical Research Center for Arthritis and Howard Hughes Medical Institute, University of California at San Francisco, 533 Parnassus Avenue, San Francisco, CA 94143-0795, USA.

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http://dx.doi.org/10.1128/MCB.25.12.4924-4933.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1140569PMC
June 2005