Jeroen E J Guikema

Jeroen E J Guikema

UNVERIFIED PROFILE

Are you Jeroen E J Guikema?   Register this Author

Register author
Jeroen E J Guikema

Jeroen E J Guikema

Publications by authors named "Jeroen E J Guikema"

Are you Jeroen E J Guikema?   Register this Author

37Publications

684Reads

19Profile Views

Base Excision Repair in the Immune System: Small DNA Lesions With Big Consequences.

Front Immunol 2020 29;11:1084. Epub 2020 May 29.

Department of Pathology, Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2020.01084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272602PMC
May 2020

Salivary gland MALT lymphomas of Sjӧgren's syndrome patients in majority express rheumatoid factors affinity-selected for IgG.

Arthritis Rheumatol 2020 Mar 17. Epub 2020 Mar 17.

Department of Pathology, Cancer Center Amsterdam, Amsterdam University Medical Center, University of Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.41263DOI Listing
March 2020

The NEDD8-activating enzyme inhibitor MLN4924 induces DNA damage in Ph+ leukemia and sensitizes for ABL kinase inhibitors.

Cell Cycle 2019 09 26;18(18):2307-2322. Epub 2019 Jul 26.

Department of Pathology, Amsterdam University Medical Centers, location AMC, University of Amsterdam , Amsterdam , The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15384101.2019.1646068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738521PMC
September 2019

The Complex Interplay between DNA Injury and Repair in Enzymatically Induced Mutagenesis and DNA Damage in B Lymphocytes.

Int J Mol Sci 2017 Aug 30;18(9). Epub 2017 Aug 30.

Department of Pathology, Academic Medical Center, University of Amsterdam; Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Amsterdam 1105 AZ, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms18091876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618525PMC
August 2017

Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay.

J Vis Exp 2017 06 9(124). Epub 2017 Jun 9.

Department of Pathology, Academic Medical Center, University of Amsterdam, Lymphoma and Myeloma Center Amsterdam (LYMMCARE);

View Article

Download full-text PDF

Source
https://www.jove.com/video/55703/detection-visualization-dna
Publisher Site
http://dx.doi.org/10.3791/55703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608333PMC
June 2017

Computational Model Reveals Limited Correlation between Germinal Center B-Cell Subclone Abundancy and Affinity: Implications for Repertoire Sequencing.

Front Immunol 2017 6;8:221. Epub 2017 Mar 6.

Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands; Bioinformatics Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2017.00221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337809PMC
March 2017

B-Lymphoblastic Lymphomas Evolving from Follicular Lymphomas Co-Express Surrogate Light Chains and Mutated Gamma Heavy Chains.

Am J Pathol 2016 12 15;186(12):3273-3284. Epub 2016 Oct 15.

Department of Pathology, Academic Medical Center Amsterdam, Amsterdam, the Netherlands; Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Amsterdam, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajpath.2016.07.027DOI Listing
December 2016

The DNA Damage Response Regulates RAG1/2 Expression in Pre-B Cells through ATM-FOXO1 Signaling.

J Immunol 2016 10 24;197(7):2918-29. Epub 2016 Aug 24.

Department of Pathology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands; Lymphoma and Myeloma Center Amsterdam, 1105 AZ Amsterdam, the Netherlands;

View Article

Download full-text PDF

Source
http://www.jimmunol.org/content/197/7/2918.full.pdf
Web Search
http://dx.doi.org/10.4049/jimmunol.1501989DOI Listing
October 2016

MYC in diffuse large B-cell lymphoma: always the bad guy?

Leuk Lymphoma 2015 18;56(11):3003-4. Epub 2015 Jun 18.

b Department of Pathology , Academic Medical Center and Lymphoma and Myeloma Center (LYMMCARE) , Amsterdam , The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/10428194.2015.1048445DOI Listing
August 2016

Identification of a novel stereotypic IGHV4-59/IGHJ5-encoded B-cell receptor subset expressed by various B-cell lymphomas with high affinity rheumatoid factor activity.

Haematologica 2016 05 8;101(5):e200-3. Epub 2016 Feb 8.

Department of Pathology and Lymphoma and Myeloma Center Amsterdam (LYMMCARE), Academic Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2015.139626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004362PMC
May 2016

NF-κB and AKT signaling prevent DNA damage in transformed pre-B cells by suppressing RAG1/2 expression and activity.

Blood 2015 Sep 7;126(11):1324-35. Epub 2015 Jul 7.

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; and Lymphoma and Myeloma Center Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-01-62
Publisher Site
http://dx.doi.org/10.1182/blood-2015-01-621623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671331PMC
September 2015

Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells.

J Immunol 2014 Jul 16;193(2):931-9. Epub 2014 Jun 16.

Department of Molecular and Physiological Systems, Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, MA 01655;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1400002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105697PMC
July 2014

ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination.

J Immunol 2014 May 11;192(10):4887-96. Epub 2014 Apr 11.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1303481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049217PMC
May 2014

A mutated B cell chronic lymphocytic leukemia subset that recognizes and responds to fungi.

J Exp Med 2013 Jan 7;210(1):59-70. Epub 2013 Jan 7.

Department of Pathology, Academic Medical Center, University of Amsterdam, 1012 ZA Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20121801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549718PMC
January 2013

Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells.

Mol Cell 2011 Jan;41(2):232-42

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655-0122, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S109727651100008
Publisher Site
http://dx.doi.org/10.1016/j.molcel.2011.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044441PMC
January 2011

p53 represses class switch recombination to IgG2a through its antioxidant function.

J Immunol 2010 Jun 5;184(11):6177-87. Epub 2010 May 5.

Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.0904085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235438PMC
June 2010

The role of Apex2 in class-switch recombination of immunoglobulin genes.

Int Immunol 2010 Mar;22(3):213; author reply 213-4

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/intimm/dxq003DOI Listing
March 2010

The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switch.

Philos Trans R Soc Lond B Biol Sci 2009 Mar;364(1517):645-52

Department of Molecular Genetics and Microbiology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01545, USA.

View Article

Download full-text PDF

Source
http://rstb.royalsocietypublishing.org/cgi/doi/10.1098/rstb.
Publisher Site
http://dx.doi.org/10.1098/rstb.2008.0200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660920PMC
March 2009

Reassessment of the role of Mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching.

J Immunol 2008 Dec;181(12):8450-9

Department of Molecular Genetics and Microbiology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656362PMC
http://dx.doi.org/10.4049/jimmunol.181.12.8450DOI Listing
December 2008

Structure and consequences of IGH switch breakpoints in Burkitt lymphoma.

J Natl Cancer Inst Monogr 2008 (39):32-6

Department of Pathology and Laboratory Medicine, University Medical Center Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jncimonographs/lgn020DOI Listing
September 2008

Mechanism and regulation of class switch recombination.

Annu Rev Immunol 2008 ;26:261-92

Department of Molecular Genetics and Microbiology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, Massachusetts 01655-012, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev.immunol.26.021607.090248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707252PMC
June 2008

Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair.

J Immunol 2007 Nov;179(9):6064-71

Department of Molecular Genetics and Microbiology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.179.9.6064DOI Listing
November 2007

APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.

J Exp Med 2007 Nov 19;204(12):3017-26. Epub 2007 Nov 19.

Department of Molecular Genetics and Microbiology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

View Article

Download full-text PDF

Source
http://www.jem.org/lookup/doi/10.1084/jem.20071289
Publisher Site
http://dx.doi.org/10.1084/jem.20071289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118529PMC
November 2007

IGH switch breakpoints in Burkitt lymphoma: exclusive involvement of noncanonical class switch recombination.

Genes Chromosomes Cancer 2006 Sep;45(9):808-19

Department of Pathology and Laboratory Medicine, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/gcc.20345DOI Listing
September 2006

Complex biallelic IGH rearrangements in IgM-expressing Z-138 cell line: Involvement of downstream immunoglobulin class switch recombination.

Genes Chromosomes Cancer 2005 Feb;42(2):164-9

Department of Pathology and Laboratory Medicine, Groningen University Medical Center, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/gcc.20132DOI Listing
February 2005

Heterogeneity in the multiple myeloma tumor clone.

Leuk Lymphoma 2004 May;45(5):857-71

Department of Cell Biology, Section Histology and Immunology, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10428190310001593201DOI Listing
May 2004

CD27-triggering on primary plasma cell leukaemia cells has anti-apoptotic effects involving mitogen activated protein kinases.

Br J Haematol 2004 Feb;124(3):299-308

Department of Cell Biology, Section Histology and Immunology, Faculty of Medical Sciences, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1046/j.1365-2141.2003.04783.xDOI Listing
February 2004

Expression of activation-induced cytidine deaminase is confined to B-cell non-Hodgkin's lymphomas of germinal-center phenotype.

Cancer Res 2003 Jul;63(14):3894-8

Department of Pathology, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
July 2003

CD27 is heterogeneously expressed in multiple myeloma: low CD27 expression in patients with high-risk disease.

Br J Haematol 2003 Apr;121(1):36-43

Department of Cell Biology, Histology and Immunology Section, University Hospital, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1046/j.1365-2141.2003.04260.xDOI Listing
April 2003

Myeloma clonotypic B cells are hampered in their ability to undergo B-cell differentiation in vitro.

Br J Haematol 2002 Oct;119(1):54-61

Department of Cell Biology, Section Histology and Immunology, University of Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1046/j.1365-2141.2002.03789.xDOI Listing
October 2002