Publications by authors named "Jeremy N Rich"

100Publications

Protein Sumoylation with SUMO1 Promoted by Pin1 in Glioma Stem Cells Augments Glioblastoma Malignancy.

Neuro Oncol 2020 Jun 27. Epub 2020 Jun 27.

Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1093/neuonc/noaa150DOI Listing
June 2020

Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.

Cell 2020 Jun 22;181(6):1329-1345.e24. Epub 2020 May 22.

The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.04.047DOI Listing
June 2020

Reprogramming the microenvironment: tricks of tumor-derived astrocytes.

Cell Res 2020 Aug;30(8):633-634

Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, CA, 92037, USA.

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http://dx.doi.org/10.1038/s41422-020-0335-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395723PMC
August 2020

Glioblastoma Stem Cells: Driving Resilience through Chaos.

Trends Cancer 2020 03 3;6(3):223-235. Epub 2020 Feb 3.

Division of Regenerative Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, 92037, USA; Sanford Consortium for Regenerative Medicine, La Jolla, CA 92037, USA; Department of Neurosciences, University of California San Diego, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2020.01.009DOI Listing
March 2020

Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αβ Axis.

Cell Stem Cell 2020 02 16;26(2):187-204.e10. Epub 2020 Jan 16.

Department of Medicine, Division of Regenerative Medicine, University of California School of Medicine, San Diego, La Jolla, CA 92037, USA; Sanford Consortium for Regenerative Medicine, 2880 Torrey Pines Scenic Drive, La Jolla, CA 92037, USA; Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.11.016DOI Listing
February 2020

Functional Enhancers Shape Extrachromosomal Oncogene Amplifications.

Cell 2019 11 21;179(6):1330-1341.e13. Epub 2019 Nov 21.

Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.10.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241652PMC
November 2019

Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock.

Cancer Discov 2019 11 27;9(11):1556-1573. Epub 2019 Aug 27.

Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center and Sanford Consortium for Regenerative Medicine, University of California, San Diego, California.

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http://dx.doi.org/10.1158/2159-8290.CD-19-0215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983300PMC
November 2019

Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling.

Cell Metab 2019 09 11;30(3):525-538.e8. Epub 2019 Jul 11.

Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pathology, UCSD School of Medicine, La Jolla, CA 92093, USA; Moores Cancer Center, UCSD School of Medicine, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742496PMC
September 2019

A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.

Cancer Cell 2019 07;36(1):51-67.e7

Arthur and Sonia Labatt Brain Tumor Research Centre, Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON M5G0A4, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada; Division of Hematology-Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON M5G1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.06.002DOI Listing
July 2019

Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer.

Genes Dev 2019 06;33(11-12):591-609

Division of Regenerative Medicine, Department of Medicine, University of California at San Diego, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1101/gad.324301.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546059PMC
June 2019

Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis.

Cell Stem Cell 2019 05 11;24(5):707-723.e8. Epub 2019 Apr 11.

Department of Pediatrics, Brain Tumor Center, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Key Laboratory of Birth Defects, Children's Hospital of Fudan University, Shanghai 201102, China. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669001PMC
May 2019

Mechanism of Action of Methotrexate Against Zika Virus.

Viruses 2019 04 10;11(4). Epub 2019 Apr 10.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.

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https://www.mdpi.com/1999-4915/11/4/338
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http://dx.doi.org/10.3390/v11040338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521145PMC
April 2019

Chromatin remodeler HELLS maintains glioma stem cells through E2F3 and MYC.

JCI Insight 2019 04 4;4(7). Epub 2019 Apr 4.

Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1172/jci.insight.126140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483649PMC
April 2019

SUFU: The Jekyll and Hyde of the Cerebellum.

Dev Cell 2019 01;48(2):131-132

Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2019.01.013DOI Listing
January 2019

Cancer Stem Cells: The Architects of the Tumor Ecosystem.

Cell Stem Cell 2019 01;24(1):41-53

Department of Medicine, Division of Regenerative Medicine, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350931PMC
January 2019

N-methyladenine DNA Modification in Glioblastoma.

Cell 2018 11 1;175(5):1228-1243.e20. Epub 2018 Nov 1.

Department of Medicine, Division of Regenerative Medicine, University of California, San Diego, La Jolla, CA 92037, USA; Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA 92037, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183131
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http://dx.doi.org/10.1016/j.cell.2018.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433469PMC
November 2018

Poly(ADP-Ribose) Polymerase Inhibition Sensitizes Colorectal Cancer-Initiating Cells to Chemotherapy.

Stem Cells 2019 01 12;37(1):42-53. Epub 2018 Nov 12.

Department of Stem Cell and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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http://doi.wiley.com/10.1002/stem.2929
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http://dx.doi.org/10.1002/stem.2929DOI Listing
January 2019

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.

Nature 2018 01 20;553(7686):101-105. Epub 2017 Dec 20.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1038/nature25169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993422PMC
January 2018

Inhibition of ID1-BMPR2 Intrinsic Signaling Sensitizes Glioma Stem Cells to Differentiation Therapy.

Clin Cancer Res 2018 01 5;24(2):383-394. Epub 2017 Dec 5.

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1529DOI Listing
January 2018

Targeting Glioma Stem Cell-Derived Pericytes Disrupts the Blood-Tumor Barrier and Improves Chemotherapeutic Efficacy.

Cell Stem Cell 2017 Nov;21(5):591-603.e4

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687837PMC
November 2017

Targeting glioma stem cells through combined BMI1 and EZH2 inhibition.

Nat Med 2017 Nov 9;23(11):1352-1361. Epub 2017 Oct 9.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1038/nm.4415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679732PMC
November 2017

Nicotinamide metabolism regulates glioblastoma stem cell maintenance.

JCI Insight 2017 May 18;2(10). Epub 2017 May 18.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1172/jci.insight.90019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436539PMC
May 2017

Messenger RNA Methylation Regulates Glioblastoma Tumorigenesis.

Cancer Cell 2017 04;31(4):474-475

Tumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482444PMC
April 2017

Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance.

Cell Stem Cell 2017 02 15;20(2):233-246.e7. Epub 2016 Dec 15.

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291795PMC
February 2017

Tetraspanin CD9 stabilizes gp130 by preventing its ubiquitin-dependent lysosomal degradation to promote STAT3 activation in glioma stem cells.

Cell Death Differ 2017 01 14;24(1):167-180. Epub 2016 Oct 14.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1038/cdd.2016.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260495PMC
January 2017

Cancer stem cells: A nuanced perspective.

Medicine (Baltimore) 2016 Sep;95(1 Suppl 1):S26-8

aDepartment of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH bThe Sidney Kimmel Comprehensive Center, The Johns Hopkins University School of Medicine, Baltimore, MD cCancer Center, Institute for Academic Medicine, Houston Methodist Hospital, Houston, TX.

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http://dx.doi.org/10.1097/MD.0000000000004559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599213PMC
September 2016

Cancer stem cells: understanding tumor hierarchy and heterogeneity.

Authors:
Jeremy N Rich

Medicine (Baltimore) 2016 Sep;95(1 Suppl 1):S2-7

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.

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http://Insights.ovid.com/crossref?an=00005792-201609081-0000
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http://dx.doi.org/10.1097/MD.0000000000004764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599210PMC
September 2016

Cancer stem cells: master gatekeepers and regulators of cancer growth and metastasis Introduction.

Authors:
Jeremy N Rich

Medicine (Baltimore) 2016 Sep;95(1 Suppl 1):S1

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.

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http://dx.doi.org/10.1097/MD.0000000000004558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599209PMC
September 2016

The ID1-CULLIN3 Axis Regulates Intracellular SHH and WNT Signaling in Glioblastoma Stem Cells.

Cell Rep 2016 08 28;16(6):1629-1641. Epub 2016 Jul 28.

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.06.092DOI Listing
August 2016

Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells.

Cancer Discov 2016 05 21;6(5):532-45. Epub 2016 Mar 21.

Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire. Norris Cotton Cancer Center, Lebanon, New Hampshire.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854766PMC
May 2016

Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models.

Cancer Res 2016 04 26;76(8):2432-42. Epub 2016 Feb 26.

Department of Cancer Biology, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio. Department of Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio. Department of Radiation Oncology, James Cancer Hospital and Comprehensive Cancer Center, The Ohio State University Wexner School of Medicine, Columbus, Ohio.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873320PMC
April 2016

An epigenetic gateway to brain tumor cell identity.

Nat Neurosci 2016 Jan;19(1):10-9

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1038/nn.4190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568053PMC
January 2016

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin.

Cancer Cell 2015 Dec 25;28(6):715-729. Epub 2015 Nov 25.

Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Division of Neurosurgery, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://www.cell.com/cancer-cell/pdf/S1535-6108(15)00382-7.pd
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http://linkinghub.elsevier.com/retrieve/pii/S153561081500382
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http://dx.doi.org/10.1016/j.ccell.2015.10.005DOI Listing
December 2015

Arsenic trioxide disrupts glioma stem cells via promoting PML degradation to inhibit tumor growth.

Oncotarget 2015 Nov;6(35):37300-15

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.18632/oncotarget.5836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741931PMC
November 2015

"PEAR-ing" Genomic and Epigenomic Analyses for Cancer Gene Discovery.

Cancer Discov 2015 Oct;5(10):1018-20

Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608252PMC
October 2015

Coordination of self-renewal in glioblastoma by integration of adhesion and microRNA signaling.

Neuro Oncol 2016 05 15;18(5):656-66. Epub 2015 Sep 15.

Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (A.G.A., S.M.T., E.E.M.-H., B.O., D.J.S., J.S.H., M.S., M.L., J.D.L.); Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio (A.G.A., J.N.R., J.D.L.); Department of Genetics, The University of Texas, MD Anderson Cancer Center, Houston, Texas (P.S., P.O.Z., S.M.); Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (W.A.F., J.N.R.); Laboratory of Biochemistry and Molecular Biology, School of Life Sciences, Yunnan University, Kunming, China (M.L.); Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois (M.R.G., K.K.V., A.J.T.); Department of Neurological Surgery, The Ohio State University, Columbus, Ohio (I.N.); Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, Ohio (M.A.V., J.N.R., J.D.L.); Case Comprehensive Cancer Center, Cleveland, Ohio (M.A.V., J.N.R., J.D.L.).

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http://dx.doi.org/10.1093/neuonc/nov196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827035PMC
May 2016

The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma.

Sci Transl Med 2015 Sep;7(304):304ra143

Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.aa
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http://dx.doi.org/10.1126/scitranslmed.aac6762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743764PMC
September 2015

Cancer stem cells in glioblastoma.

Genes Dev 2015 Jun;29(12):1203-17

Department of Molecular Medicine, Cleveland Clinic, Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.261982.115
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http://dx.doi.org/10.1101/gad.261982.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495393PMC
June 2015

Growth Factor Receptor Fusions Predict Therapeutic Sensitivity.

Clin Cancer Res 2015 Jul 20;21(14):3105-7. Epub 2015 May 20.

Burkhardt Brain Tumor Neuro-Oncology Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio. Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-0458DOI Listing
July 2015

Differential connexin function enhances self-renewal in glioblastoma.

Cell Rep 2015 May 7;11(7):1031-42. Epub 2015 May 7.

Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44915, USA; Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA; Rose Ella Burkhardt Brain Tumor and Neuro Oncology Center, Cleveland Clinic, Cleveland, OH 44195, USA; Case Comprehensive Cancer Center, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502443PMC
May 2015

Feedback circuitry between miR-218 repression and RTK activation in glioblastoma.

Sci Signal 2015 May 5;8(375):ra42. Epub 2015 May 5.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/scisignal.2005978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437515PMC
May 2015

CDC20 maintains tumor initiating cells.

Oncotarget 2015 May;6(15):13241-54

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537011PMC
http://dx.doi.org/10.18632/oncotarget.3676DOI Listing
May 2015

Mitochondrial control by DRP1 in brain tumor initiating cells.

Nat Neurosci 2015 Apr 2;18(4):501-10. Epub 2015 Mar 2.

1] Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland, Ohio, USA. [2] Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1038/nn.3960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376639PMC
April 2015

High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues.

Nat Photonics 2014;8:627-634

Biosystems and Biomaterials Division, National Institute of Standards and Technology, 100 Bureau Dr, Gaithersburg, MD 20899, USA.

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http://www.nature.com/articles/nphoton.2014.145
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http://dx.doi.org/10.1038/nphoton.2014.145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304702PMC
January 2014

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth.

Nat Cell Biol 2015 Feb 12;17(2):170-82. Epub 2015 Jan 12.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1038/ncb3090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312504PMC
February 2015

Lgr5 Marks Post-Mitotic, Lineage Restricted Cerebellar Granule Neurons during Postnatal Development.

PLoS One 2014 10;9(12):e114433. Epub 2014 Dec 10.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114433PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262395PMC
October 2017

Sema3C promotes the survival and tumorigenicity of glioma stem cells through Rac1 activation.

Cell Rep 2014 Dec 20;9(5):1812-1826. Epub 2014 Nov 20.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA; Burkhardt Brain Tumor and Neuro-Oncology Center, Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA; Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.10.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268066PMC
December 2014

Development of a Sox2 reporter system modeling cellular heterogeneity in glioma.

Neuro Oncol 2015 Mar 21;17(3):361-71. Epub 2014 Nov 21.

Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio (K.S., M.S., J.S.H., B.O., J.D.L.); Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio (Q.W., J.N.R.); Department of Biological, Geological, and Environmental Sciences, Cleveland State University, Cleveland, Ohio (M.S., J.D.L.); Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama (K.W., A.B.H.); Image I.Q., Cleveland, Ohio (A.V.); Case Comprehensive Cancer Center, Cleveland, Ohio (J.N.R., J.D.L.).

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http://dx.doi.org/10.1093/neuonc/nou320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483103PMC
March 2015

Molecular targeting of TRF2 suppresses the growth and tumorigenesis of glioblastoma stem cells.

Glia 2014 Oct 7;62(10):1687-98. Epub 2014 Jun 7.

Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China; Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland.

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http://dx.doi.org/10.1002/glia.22708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141001PMC
October 2014

The zinc finger transcription factor ZFX is required for maintaining the tumorigenic potential of glioblastoma stem cells.

Stem Cells 2014 Aug;32(8):2033-47

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1002/stem.1730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349564PMC
August 2014

Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy.

Genes Dev 2014 May 1;28(10):1085-100. Epub 2014 May 1.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA;

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http://dx.doi.org/10.1101/gad.235515.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035537PMC
May 2014

Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation.

Nat Cell Biol 2014 May 20;16(5):445-56. Epub 2014 Apr 20.

Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue Cleveland, Ohio 44195, USA.

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http://www.nature.com/articles/ncb2954
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http://dx.doi.org/10.1038/ncb2954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036069PMC
May 2014

High-throughput flow cytometry screening reveals a role for junctional adhesion molecule a as a cancer stem cell maintenance factor.

Cell Rep 2014 Jan 27;6(1):117-29. Epub 2013 Dec 27.

Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA; Case Comprehensive Cancer Center, Cleveland, OH 44106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2013.11.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899718PMC
January 2014

miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma.

Proc Natl Acad Sci U S A 2014 Jan 24;111(1):291-6. Epub 2013 Dec 24.

Abramson Family Cancer Research Institute, Howard Hughes Medical Institute, Penn Molecular Profiling Facility - Bioinformatics Group, and Departments of Cell and Developmental Biology, Pathology and Laboratory Medicine, Cancer Biology, and Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104.

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http://dx.doi.org/10.1073/pnas.1314341111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890843PMC
January 2014

Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A.

J Exp Med 2013 Dec 9;210(13):2851-72. Epub 2013 Dec 9.

Department of Stem Cell Biology and Regenerative Medicine, 2 Department of Cellular and Molecular Medicine, and 3 Department of Cancer Biology, Lerner Research Institute; 4 Department of Colorectal Surgery, Digestive Disease Institute; 5 Department of Anatomical Pathology, Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195.

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http://dx.doi.org/10.1084/jem.20131195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865474PMC
December 2013

The Lgr5 transgene is expressed specifically in glycinergic amacrine cells in the mouse retina.

Exp Eye Res 2014 Feb 15;119:106-10. Epub 2013 Nov 15.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH 44195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2013.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986349PMC
February 2014

The evolving landscape of glioblastoma stem cells.

Curr Opin Neurol 2013 Dec;26(6):701-7

aDepartment of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic bCase Western Reserve University School of Medicine cDepartment of Cell Biology, Case Western Reserve University dCleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1097/WCO.0000000000000032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031658PMC
December 2013

Genomics informs glioblastoma biology.

Nat Genet 2013 Oct;45(10):1105-7

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1038/ng.2775DOI Listing
October 2013

Leptin receptor maintains cancer stem-like properties in triple negative breast cancer cells.

Endocr Relat Cancer 2013 Dec 14;20(6):797-808. Epub 2013 Oct 14.

Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, Ohio 44195, USA Department of Nutritional Sciences, The University of Texas, Austin, Texas, USA Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, Texas, USA Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA ImageIQ, Cleveland, Ohio, USA Case Comprehensive Cancer Center, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1530/ERC-13-0329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843956PMC
December 2013

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake.

Nat Neurosci 2013 Oct 1;16(10):1373-82. Epub 2013 Sep 1.

1] Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, Ohio, USA. [2] Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1038/nn.3510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930177PMC
October 2013