Jeremy M Stark

Jeremy M Stark

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Jeremy M Stark

Jeremy M Stark

Publications by authors named "Jeremy M Stark"

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USP22 Interacts with PALB2 and Promotes Chemotherapy Resistance via Homologous Recombination of DNA Double-Strand Breaks.

Mol Cancer Res 2020 Mar 4;18(3):424-435. Epub 2019 Nov 4.

Division of Thoracic Surgery, Baum Family Thoracic Oncology Laboratory, City of Hope National Medical Center, Duarte, California.

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http://dx.doi.org/10.1158/1541-7786.MCR-19-0053DOI Listing
March 2020

The RAD52-S346X variant reduces risk of developing breast cancer in carriers of pathogenic germline BRCA2 mutations.

Mol Oncol 2020 Mar 16. Epub 2020 Mar 16.

Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA.

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http://dx.doi.org/10.1002/1878-0261.12665DOI Listing
March 2020

Functional deficiency of DNA repair gene EXO5 results in androgen-induced genomic instability and prostate tumorigenesis.

Oncogene 2020 Feb 15;39(6):1246-1259. Epub 2019 Oct 15.

Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope, Duarte, USA.

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http://dx.doi.org/10.1038/s41388-019-1061-6DOI Listing
February 2020

BLM has Contrary Effects on Repeat-Mediated Deletions, based on the Distance of DNA DSBs to a Repeat and Repeat Divergence.

Cell Rep 2020 Feb;30(5):1342-1357.e4

Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA; Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085117PMC
February 2020

The canonical non-homologous end joining factor XLF promotes chromosomal deletion rearrangements in human cells.

J Biol Chem 2020 Jan 21;295(1):125-137. Epub 2019 Nov 21.

Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, California 91010

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http://dx.doi.org/10.1074/jbc.RA119.010421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952595PMC
January 2020

Distinct roles of RAD52 and POLQ in chromosomal break repair and replication stress response.

PLoS Genet 2019 08 5;15(8):e1008319. Epub 2019 Aug 5.

Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695211PMC
August 2019

C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains.

Nat Commun 2018 06 27;9(1):2484. Epub 2018 Jun 27.

Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, 1500 E Duarte Rd., Duarte, CA, 91010, USA.

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http://www.nature.com/articles/s41467-018-04867-5
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http://dx.doi.org/10.1038/s41467-018-04867-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021437PMC
June 2018

Repeat-mediated deletions can be induced by a chromosomal break far from a repeat, but multiple pathways suppress such rearrangements.

Genes Dev 2018 04 10;32(7-8):524-536. Epub 2018 Apr 10.

Department of Cancer Genetics and Epigenetics, City of Hope, Duarte, California 91010, USA.

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http://dx.doi.org/10.1101/gad.311084.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959236PMC
April 2018

PRPF8 is important for BRCA1-mediated homologous recombination.

Oncotarget 2017 Nov 6;8(55):93319-93337. Epub 2017 Oct 6.

Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, CA, USA.

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http://dx.doi.org/10.18632/oncotarget.21555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706798PMC
November 2017

Contribution of canonical nonhomologous end joining to chromosomal rearrangements is enhanced by ATM kinase deficiency.

Proc Natl Acad Sci U S A 2017 01 5;114(4):728-733. Epub 2017 Jan 5.

Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, CA 91010;

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http://dx.doi.org/10.1073/pnas.1612204114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278456PMC
January 2017

RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner.

Cell Cycle 2016 ;15(6):787-98

a Department of Molecular Pharmacology , Beckman Research Institute, City of Hope , Duarte , CA , USA.

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http://dx.doi.org/10.1080/15384101.2016.1138184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845925PMC
December 2016

Regulation of Single-Strand Annealing and its Role in Genome Maintenance.

Trends Genet 2016 09 19;32(9):566-575. Epub 2016 Jul 19.

Department of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, CA, USA; Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tig.2016.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992407PMC
September 2016

Myelodysplasia-associated mutations in serine/arginine-rich splicing factor SRSF2 lead to alternative splicing of CDC25C.

BMC Mol Biol 2016 08 23;17(1):18. Epub 2016 Aug 23.

Department of Molecular and Cellular Biology, Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, 91010, USA.

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http://dx.doi.org/10.1186/s12867-016-0071-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994158PMC
August 2016

Tetratricopeptide repeat factor XAB2 mediates the end resection step of homologous recombination.

Nucleic Acids Res 2016 07 15;44(12):5702-16. Epub 2016 Apr 15.

Department of Cancer Genetics and Epigenetics, 1500 E Duarte Rd., Duarte, CA 91010, USA Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, 1500 E Duarte Rd., Duarte, CA 91010, USA

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http://dx.doi.org/10.1093/nar/gkw275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937314PMC
July 2016

A PCNA-derived cell permeable peptide selectively inhibits neuroblastoma cell growth.

PLoS One 2014 11;9(4):e94773. Epub 2014 Apr 11.

Department of Molecular & Cellular Biology, Beckman Research Institute of City of Hope, Duarte, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094773PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984256PMC
May 2015

DNA damage response factors from diverse pathways, including DNA crosslink repair, mediate alternative end joining.

PLoS Genet 2015 Jan 28;11(1):e1004943. Epub 2015 Jan 28.

Department of Radiation Biology, Beckman Research Institute of the City of Hope, Duarte, California, United States of America; Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309583PMC
January 2015

TGFβ induces "BRCAness" and sensitivity to PARP inhibition in breast cancer by regulating DNA-repair genes.

Mol Cancer Res 2014 Nov 7;12(11):1597-609. Epub 2014 Aug 7.

Department of Cancer Biology, City of Hope Beckman Research Institute and Medical Center, Duarte, California. Department of Biotherapy and Key Laboratory of Cancer Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233161PMC
November 2014

An RNF168 fragment defective for focal accumulation at DNA damage is proficient for inhibition of homologous recombination in BRCA1 deficient cells.

Nucleic Acids Res 2014 Jul 14;42(12):7720-33. Epub 2014 May 14.

Department of Radiation Biology, Beckman Research Institute of the City of Hope, 1500 E Duarte Road, Duarte, CA 91010, USA Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, 1500 E Duarte Road, Duarte, CA 91010, USA

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http://dx.doi.org/10.1093/nar/gku421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081061PMC
July 2014

Visualization of local DNA unwinding by Mre11/Rad50/Nbs1 using single-molecule FRET.

Proc Natl Acad Sci U S A 2013 Nov 4;110(47):18868-73. Epub 2013 Nov 4.

Department of Chemistry and Biochemistry, Department of Molecular Genetics and Microbiology, Institute for Cellular and Molecular Biology, and Howard Hughes Medical Institute, University of Texas, Austin, TX 78712.

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http://dx.doi.org/10.1073/pnas.1309816110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839711PMC
November 2013

HP1 promotes tumor suppressor BRCA1 functions during the DNA damage response.

Nucleic Acids Res 2013 Jun 15;41(11):5784-98. Epub 2013 Apr 15.

Department of Molecular Pharmacology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1093/nar/gkt231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675466PMC
June 2013

The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression.

J Cell Biol 2013 May;201(5):693-707

Institute for Cancer Genetics, Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1083/jcb.201302145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664708PMC
May 2013

I-SceI-based assays to examine distinct repair outcomes of mammalian chromosomal double strand breaks.

Methods Mol Biol 2012 ;920:379-91

Department of Cancer Biology, Irell and Nanella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA.

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http://dx.doi.org/10.1007/978-1-61779-998-3_27DOI Listing
January 2013

The HSV-1 exonuclease, UL12, stimulates recombination by a single strand annealing mechanism.

PLoS Pathog 2012 9;8(8):e1002862. Epub 2012 Aug 9.

Molecular, Microbial and Structural Biology Department, University of Connecticut Health Center, Farmington, Connecticut, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1002862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415443PMC
December 2012

RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1.

J Biol Chem 2012 Nov 10;287(48):40618-28. Epub 2012 Oct 10.

Department of Radiation Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1074/jbc.M112.410951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504775PMC
November 2012

Examining the roles of DNA2 during mammalian end resection.

Cell Cycle 2012 Nov 25;11(22):4111. Epub 2012 Oct 25.

Department of Radiation Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA, USA.

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http://www.tandfonline.com/doi/abs/10.4161/cc.22605
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http://dx.doi.org/10.4161/cc.22605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524202PMC
November 2012

RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells.

Nucleic Acids Res 2012 Aug 9;40(15):7347-57. Epub 2012 May 9.

Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1093/nar/gks353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424541PMC
August 2012

Suberoylanilide hydroxamic acid as a radiosensitizer through modulation of RAD51 protein and inhibition of homology-directed repair in multiple myeloma.

Mol Cancer Res 2012 Aug 22;10(8):1052-64. Epub 2012 Jun 22.

Department of Radiation Oncology, City of Hope Cancer Center, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-11-0587DOI Listing
August 2012

Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context.

J Biol Chem 2011 Dec 24;286(49):42470-82. Epub 2011 Oct 24.

Department of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA.

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http://dx.doi.org/10.1074/jbc.M111.309252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234933PMC
December 2011

The relative efficiency of homology-directed repair has distinct effects on proper anaphase chromosome separation.

Nucleic Acids Res 2011 Aug 31;39(14):5935-44. Epub 2011 Mar 31.

Department of Cancer Biology, Beckman Research Institute of the City of Hope, 1500 E Duarte Rd, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1093/nar/gkr187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152340PMC
August 2011

Interhomolog recombination and loss of heterozygosity in wild-type and Bloom syndrome helicase (BLM)-deficient mammalian cells.

Proc Natl Acad Sci U S A 2011 Jul 5;108(29):11971-6. Epub 2011 Jul 5.

Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1073/pnas.1104421108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141969PMC
July 2011

Subtelomeric regions in mammalian cells are deficient in DNA double-strand break repair.

DNA Repair (Amst) 2011 May 3;10(5):536-44. Epub 2011 Apr 3.

Department of Radiation Oncology, University of California San Francisco, 94143-1331, United States.

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http://dx.doi.org/10.1016/j.dnarep.2011.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084351PMC
May 2011

ATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaks.

PLoS Genet 2010 Nov 4;6(11):e1001194. Epub 2010 Nov 4.

Department of Cancer Biology and Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, Duarte, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1001194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973825PMC
November 2010

Mammalian Fbh1 is important to restore normal mitotic progression following decatenation stress.

DNA Repair (Amst) 2010 Jun 24;9(6):708-17. Epub 2010 Apr 24.

Department of Cancer Biology, Division of Radiation Biology, Beckman Research Institute of the City of Hope, 1500 E Duarte Rd., Duarte, CA 91010, USA.

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http://dx.doi.org/10.1016/j.dnarep.2010.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883650PMC
June 2010

Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity.

J Biol Chem 2010 May 25;285(21):15739-45. Epub 2010 Mar 25.

Institute of Molecular Cancer Research, University of Zurich, CH-8057 Zurich, Switzerland.

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http://dx.doi.org/10.1074/jbc.M110.110478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871440PMC
May 2010

Limiting the persistence of a chromosome break diminishes its mutagenic potential.

PLoS Genet 2009 Oct 16;5(10):e1000683. Epub 2009 Oct 16.

Department of Cancer Biology, Division of Radiation Biology, Beckman Research Institute of the City of Hope, Duarte, California, USA.

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https://dx.plos.org/10.1371/journal.pgen.1000683
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http://dx.doi.org/10.1371/journal.pgen.1000683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752804PMC
October 2009

Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair.

PLoS Genet 2008 Jun 27;4(6):e1000110. Epub 2008 Jun 27.

Department of Radiation Biology, Beckman Research Institute of City of Hope, Duarte, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430616PMC
June 2008

RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.

Genes Dev 2007 Dec 14;21(23):3073-84. Epub 2007 Nov 14.

Department of Genetics, Case Comprehensive Cancer Centre, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://www.genesdev.org/cgi/doi/10.1101/gad.1609107
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http://dx.doi.org/10.1101/gad.1609107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2081974PMC
December 2007

Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions.

Proc Natl Acad Sci U S A 2006 Jun 26;103(23):8768-73. Epub 2006 May 26.

Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1073/pnas.0600298103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482653PMC
June 2006

Genetic steps of mammalian homologous repair with distinct mutagenic consequences.

Mol Cell Biol 2004 Nov;24(21):9305-16

Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021, USA.

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http://dx.doi.org/10.1128/MCB.24.21.9305-9316.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC522275PMC
November 2004

Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability.

Oncogene 2004 Jan;23(2):546-53

Department of Pathology, Institute of Cancer Genetics, Columbia University College of Physicians and Surgeons, 1150 St Nicholas Avenue, New York, NY 10032, USA.

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http://dx.doi.org/10.1038/sj.onc.1207098DOI Listing
January 2004

Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaks.

Mol Cell Biol 2003 Jan;23(2):733-43

Cell Biology Program, Memorial Sloan-Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151548PMC
http://dx.doi.org/10.1128/mcb.23.2.733-743.2003DOI Listing
January 2003

ATP hydrolysis by mammalian RAD51 has a key role during homology-directed DNA repair.

J Biol Chem 2002 Jun 28;277(23):20185-94. Epub 2002 Mar 28.

Cell Biology Program, Memorial Sloan-Kettering Cancer Center and Cornell University Graduate School of Medical Sciences, New York, New York 10021.

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http://dx.doi.org/10.1074/jbc.M112132200DOI Listing
June 2002

Variant XRCC3 implicated in cancer is functional in homology-directed repair of double-strand breaks.

Oncogene 2002 Jun;21(26):4176-80

Cell Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1038/sj.onc.1205539DOI Listing
June 2002