Jeremy M Simon

Jeremy M Simon

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Jeremy M Simon

Jeremy M Simon

Publications by authors named "Jeremy M Simon"

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High-throughput screening and classification of chemicals and their effects on neuronal gene expression using RASL-seq.

Sci Rep 2019 Mar 14;9(1):4529. Epub 2019 Mar 14.

Department of Cell Biology and Physiology, UNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1038/s41598-019-39016-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418307PMC
March 2019

Single-cell transcriptomic analysis of mouse neocortical development.

Nat Commun 2019 01 11;10(1):134. Epub 2019 Jan 11.

Department of Cell Biology and Physiology, UNC Neuroscience Center, The University of North Carolina at Chapel Hill, 115 Mason Farm Road, Chapel Hill, NC, 27599, USA.

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http://www.nature.com/articles/s41467-018-08079-9
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http://dx.doi.org/10.1038/s41467-018-08079-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329831PMC
January 2019

Tissue- and strain-specific effects of a genotoxic carcinogen 1,3-butadiene on chromatin and transcription.

Mamm Genome 2018 02 10;29(1-2):153-167. Epub 2018 Feb 10.

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.

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http://dx.doi.org/10.1007/s00335-018-9739-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095468PMC
February 2018

Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma.

Neuro Oncol 2017 Oct;19(11):1469-1480

Pathobiology and Translational Science Graduate Program, Departments of Pathology and Laboratory Medicine, Biology, Pharmacology, Genetics, Medicine, and Neurology, Divisions of Neuropathology and Hematology/Oncology, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, Proteomics Core Facility, Neurosciences Center, Carolina Institute for Developmental Disabilities, and Biological and Biomedical Sciences Program, University of North Carolina (UNC) School of Medicine, Chapel Hill, North Carolina; Cancer & Cell Biology Division, TGen, Phoenix, Arizona; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota; Department of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1093/neuonc/nox044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737415PMC
October 2017

Enhanced Nociception in Angelman Syndrome Model Mice.

J Neurosci 2017 10 20;37(42):10230-10239. Epub 2017 Sep 20.

Department of Cell Biology and Physiology and University of North Carolina Neuroscience Center,

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http://dx.doi.org/10.1523/JNEUROSCI.1018-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647775PMC
October 2017

Genomic profiles of low-grade murine gliomas evolve during progression to glioblastoma.

Neuro Oncol 2017 Sep;19(9):1237-1247

Curriculum in Genetics and Molecular Biology, Pathobiology and Translational Science Graduate Program, Division of Neuropathology, Department of Pathology and Laboratory Medicine, Carolina Institute for Developmental Disabilities and Department of Genetics, Lineberger Comprehensive Cancer Center, Neurosciences Center, and Department of Neurology, University of North Carolina (UNC) School of Medicine, Chapel Hill, North Carolina;Cancer & Cell Biology Division, Translational Genomics Institute (TGen), Phoenix, Arizona.

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http://dx.doi.org/10.1093/neuonc/nox050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570221PMC
September 2017

Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms.

PLoS One 2016 27;11(5):e0156439. Epub 2016 May 27.

Department of Cell Biology and Physiology, UNC Neuroscience Center, Carolina Institute for Developmental Disabilities, The University of North Carolina, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0156439PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883752PMC
July 2017

Widespread Chromatin Accessibility at Repetitive Elements Links Stem Cells with Human Cancer.

Cell Rep 2016 11;17(6):1607-1620

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pediatrics, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267842PMC
November 2016

Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide.

Neuro Oncol 2016 07 28;18(7):962-73. Epub 2016 Jan 28.

Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina (R.S.S., L.H., M.G.E., J.W., C.R.M.); Division of Neuropathology, Department of Pathology & Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina (M.V., R.S.M., R.E.B., A.M.W., K.K.W., C.R.M.); Carolina Institute for Developmental Disabilities and Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, North Carolina (J.M.S.); Department of Neurosurgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina (M.G.E., J.W.); Department of Neurology and Neurosciences Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina (C.R.M.).

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http://dx.doi.org/10.1093/neuonc/nov321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896545PMC
July 2016

High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility.

Proc Natl Acad Sci U S A 2016 Mar 29;113(11):3018-23. Epub 2016 Feb 29.

Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Carolina Center for Genome Sciences, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

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http://dx.doi.org/10.1073/pnas.1521827113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801272PMC
March 2016

Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration.

Nat Commun 2016 Mar 31;7:11173. Epub 2016 Mar 31.

Department of Cell Biology and Physiology, UNC Neuroscience Center, University of North Carolina at Chapel Hill, 111 Mason Farm Road, Chapel Hill, North Carolina 27599-7545, USA.

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http://dx.doi.org/10.1038/ncomms11173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821887PMC
March 2016

A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin.

J Biol Chem 2015 Oct 3;290(43):26088-102. Epub 2015 Sep 3.

the Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27599,

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http://dx.doi.org/10.1074/jbc.M115.654459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646261PMC
October 2015

Gene length matters in neurons.

Neuron 2015 Apr;86(2):353-5

Department of Cell Biology and Physiology, UNC Neuroscience Center, The Carolina Institute for Developmental Disabilities, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7545, USA.

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http://dx.doi.org/10.1016/j.neuron.2015.03.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584405PMC
April 2015

PTEN deficiency mediates a reciprocal response to IGFI and mTOR inhibition.

Mol Cancer Res 2014 Nov 3;12(11):1610-20. Epub 2014 Jul 3.

Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233155PMC
November 2014

LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues.

J Cell Biol 2014 Oct;207(2):299-315

University of North Carolina Lineberger Comprehensive Cancer Center, Department of Cell Biology and Physiology, Department of Genetics, Department of Biomedical Engineering, Carolina Center for Genome Science, Department of Pediatrics, and Howard Hughes Medical Institute, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599 University of North Carolina Lineberger Comprehensive Cancer Center, Department of Cell Biology and Physiology, Department of Genetics, Department of Biomedical Engineering, Carolina Center for Genome Science, Department of Pediatrics, and Howard Hughes Medical Institute, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599 University of North Carolina Lineberger Comprehensive Cancer Center, Department of Cell Biology and Physiology, Department of Genetics, Department of Biomedical Engineering, Carolina Center for Genome Science, Department of Pediatrics, and Howard Hughes Medical Institute, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599

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http://dx.doi.org/10.1083/jcb.201404067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210439PMC
October 2014

A chemical tool for in vitro and in vivo precipitation of lysine methyltransferase G9a.

ChemMedChem 2014 Mar 17;9(3):549-53. Epub 2014 Jan 17.

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Chapel Hill, NC 27599 (USA).

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http://dx.doi.org/10.1002/cmdc.201300450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005005PMC
March 2014

The open chromatin landscape of Kaposi's sarcoma-associated herpesvirus.

J Virol 2013 Nov 28;87(21):11831-42. Epub 2013 Aug 28.

Lineberger Comprehensive Cancer Center.

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http://dx.doi.org/10.1128/JVI.01685-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807352PMC
November 2013

A detailed protocol for formaldehyde-assisted isolation of regulatory elements (FAIRE).

Curr Protoc Mol Biol 2013 ;Chapter 21:Unit21.26

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1002/0471142727.mb2126s102DOI Listing
June 2013

Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription.

Genome Res 2012 Feb 15;22(2):259-70. Epub 2011 Nov 15.

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1101/gr.125666.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266033PMC
February 2012

Using formaldehyde-assisted isolation of regulatory elements (FAIRE) to isolate active regulatory DNA.

Nat Protoc 2012 Jan 19;7(2):256-67. Epub 2012 Jan 19.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/nprot.2011.444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784247PMC
January 2012