Publications by authors named "Jeremy L Jenkins"

58 Publications

Indolyl-Pyridinyl-Propenone-Induced Methuosis through the Inhibition of PIKFYVE.

ACS Omega 2018 Jun 5;3(6):6097-6103. Epub 2018 Jun 5.

Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

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June 2018

Quantitative Prioritization of Tool Compounds for Phenotypic Screening.

Methods Mol Biol 2018 ;1787:195-206

Novartis Institutes for BioMedical Research Inc., Cambridge, MA, USA.

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February 2019

Drug discovery and development in the era of Big Data.

Future Med Chem 2016 Oct 21;8(15):1807-1813. Epub 2016 Sep 21.

Relay Therapeutics, 215 First St, Cambridge, MA 02142, USA.

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October 2016

Data-Driven Derivation of an "Informer Compound Set" for Improved Selection of Active Compounds in High-Throughput Screening.

J Chem Inf Model 2016 09 16;56(9):1622-30. Epub 2016 Aug 16.

Developmental & Molecular Pathways, Novartis Institutes for BioMedical Research , Novartis Pharma AG, Novartis Campus, 4056 Basel, Switzerland.

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September 2016

Evidence-Based and Quantitative Prioritization of Tool Compounds in Phenotypic Drug Discovery.

Cell Chem Biol 2016 07 14;23(7):862-874. Epub 2016 Jul 14.

Novartis Institutes for BioMedical Research Inc., 250 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address:

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July 2016

Identifying compound efficacy targets in phenotypic drug discovery.

Drug Discov Today 2016 Jan 10;21(1):82-89. Epub 2015 Aug 10.

Developmental & Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA. Electronic address:

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January 2016

Using information from historical high-throughput screens to predict active compounds.

J Chem Inf Model 2014 Jul 26;54(7):1880-91. Epub 2014 Jun 26.

Novartis Institutes for BioMedical Research, Novartis Pharma AG , Novartis Campus, 4056 Basel, Switzerland.

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July 2014

Causal Network Models for Predicting Compound Targets and Driving Pathways in Cancer.

J Biomol Screen 2014 Jun 11;19(5):791-802. Epub 2014 Feb 11.

Developmental & Molecular Pathways, Novartis Institutes for BioMedical Research, Inc., Cambridge, MA, USA.

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June 2014

Drug discovery: Rethinking cellular drug response.

Authors:
Jeremy L Jenkins

Nat Chem Biol 2013 Nov;9(11):669-70

Department of Developmental and Molecular Pathways at the Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.

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November 2013

Large-Scale QSAR in Target Prediction and Phenotypic HTS Assessment.

Authors:
Jeremy L Jenkins

Mol Inform 2012 Jul 12;31(6-7):508-14. Epub 2012 Jul 12.

Developmental and Molecular Pathways, Quantitative Biology, Novartis Institutes for BioMedical Research, 220 Massachusetts Ave., Cambridge, MA 02139 phone: 617-871-7155.

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July 2012

Rethinking molecular similarity: comparing compounds on the basis of biological activity.

ACS Chem Biol 2012 Aug 31;7(8):1399-409. Epub 2012 May 31.

Center for Proteomic Chemistry, Novartis Institutes for Biomedical Research Inc., 250 Massachusetts Avenue, Cambridge, MA 02139, USA.

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August 2012

Determination of minimal transcriptional signatures of compounds for target prediction.

EURASIP J Bioinform Syst Biol 2012 May 10;2012(1). Epub 2012 May 10.

Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus Basel, CH-4056, Basel, Switzerland.

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May 2012

Activity-aware clustering of high throughput screening data and elucidation of orthogonal structure-activity relationships.

J Chem Inf Model 2011 Dec 7;51(12):3158-68. Epub 2011 Dec 7.

Novartis Institutes for Biomedical Research, 250 Massachusetts Ave., Cambridge, Massachusetts 02139, USA.

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December 2011

Computational methods for early predictive safety assessment from biological and chemical data.

Expert Opin Drug Metab Toxicol 2011 Dec 4;7(12):1497-511. Epub 2011 Nov 4.

Novartis Institutes for BioMedical Research, Inc., Chemical Biology Informatics, Quantitative Biology, Developmental and Molecular Pathways, 220 Massachusetts Avenue, 02139 Cambridge, MA, USA.

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December 2011

From in silico target prediction to multi-target drug design: current databases, methods and applications.

J Proteomics 2011 Nov 18;74(12):2554-74. Epub 2011 May 18.

Unilever Centre for Molecular Sciences Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.

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November 2011

A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space.

Protein Sci 2010 Nov;19(11):2096-109

Lead Discovery Informatics, Lead Finding Platform, Novartis Institutes for BioMedical Research, Inc., 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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November 2010

Phenotypic screening: Fishing for neuroactive compounds.

Nat Chem Biol 2010 Mar;6(3):172-173

Jeremy L. Jenkins and Laszlo Urban are in the Center for Proteomic Chemistry, Lead Finding Platform, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.

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March 2010

Chemogenomic analysis of safety profiling data.

Methods Mol Biol 2009 ;575:207-23

Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.

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February 2010

Plate-based diversity selection based on empirical HTS data to enhance the number of hits and their chemical diversity.

J Biomol Screen 2009 Jul 16;14(6):690-9. Epub 2009 Jun 16.

Lead Discovery Informatics, Center for Proteomic Chemistry Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA.

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July 2009