Jeremy Burrows

Jeremy Burrows

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Jeremy Burrows

Jeremy Burrows

Publications by authors named "Jeremy Burrows"

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The Development Process for Discovery and Clinical Advancement of Modern Antimalarials.

J Med Chem 2019 Dec 20;62(23):10526-10562. Epub 2019 Aug 20.

The Walter and Eliza Hall Institute of Medical Research , Parkville , Victoria 3052 , Australia.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00761DOI Listing
December 2019

Blocking Development in Mosquitoes: A Powerful New Approach for Expanding Malaria Control Efforts.

Am J Trop Med Hyg 2019 10;101(4):734-735

Innovative Vector Control Consortium, Liverpool, United Kingdom.

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http://dx.doi.org/10.4269/ajtmh.19-0318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779223PMC
October 2019

Evaluation of Current and Emerging Antimalarial Medicines for Inhibition of Toxoplasma gondii Growth in Vitro.

ACS Infect Dis 2018 08 25;4(8):1264-1274. Epub 2018 Jul 25.

Department of Molecular Microbiology , Washington University School of Medicine in St. Louis , 600 S. Euclid Avenue , St. Louis , Missouri 63110 , United States.

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http://dx.doi.org/10.1021/acsinfecdis.8b00113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093624PMC
August 2018

Malaria.

Nat Rev Dis Primers 2017 Aug 3;3:17050. Epub 2017 Aug 3.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1038/nrdp.2017.50DOI Listing
August 2017

Parasite physiology: No longer lost in translation.

Authors:
Jeremy Burrows

Nat Microbiol 2017 05 25;2:17055. Epub 2017 May 25.

Medicines for Malaria Venture, Route de Pré Bois 20, 1215 Meyrin, Geneva 15, Switzerland.

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http://dx.doi.org/10.1038/nmicrobiol.2017.55DOI Listing
May 2017

Open data in drug discovery and development: lessons from malaria.

Nat Rev Drug Discov 2016 10 12;15(10):661-2. Epub 2016 Aug 12.

Medicines for Malaria Venture, 20 Route de Pré-Bois, Geneva 1215, Switzerland.

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http://dx.doi.org/10.1038/nrd.2016.154DOI Listing
October 2016

ICI 56,780 Optimization: Structure-Activity Relationship Studies of 7-(2-Phenoxyethoxy)-4(1H)-quinolones with Antimalarial Activity.

J Med Chem 2016 07 12;59(14):6943-60. Epub 2016 Jul 12.

Department of Chemistry, University of South Florida , CHE 205, 4202 E. Fowler Avenue, Tampa, Florida 33620, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b00759DOI Listing
July 2016

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

Hit and lead criteria in drug discovery for infectious diseases of the developing world.

Nat Rev Drug Discov 2015 Nov 5;14(11):751-8. Epub 2015 Oct 5.

Global Health Innovative Technology (GHIT) Fund, Ark Hills, Sengokuyama Mori Tower (25F), 1-9-10 Roppongi, Minato-ku, Tokyo 106-0032, Japan.

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http://dx.doi.org/10.1038/nrd4683DOI Listing
November 2015

A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments.

PLoS Negl Trop Dis 2015 Oct 8;9(10):e0003987. Epub 2015 Oct 8.

Medicines for Malaria Venture, Geneva, Switzerland; Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0003987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598153PMC
October 2015

ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria.

Antimicrob Agents Chemother 2015 Sep 29;59(9):5555-60. Epub 2015 Jun 29.

VA Medical Center, Experimental Chemotherapy Laboratory, Portland, Oregon, USA Oregon Health & Science University, Department of Molecular Microbiology and Immunology, Portland, Oregon, USA

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http://dx.doi.org/10.1128/AAC.01183-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538462PMC
September 2015

Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum.

Antimicrob Agents Chemother 2015 Apr 20;59(4):1977-82. Epub 2015 Jan 20.

Departments of Physiology and Pharmacology, Molecular Microbiology, and Immunology, Oregon Health & Science University, Portland, Oregon, USA VA Medical Center, Portland, Oregon, USA

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http://dx.doi.org/10.1128/AAC.04149-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356778PMC
April 2015

Microbiology: Malaria runs rings round artemisinin.

Authors:
Jeremy Burrows

Nature 2015 Apr 15;520(7549):628-30. Epub 2015 Apr 15.

Medicines for Malaria Venture, 1215 Meyrin, Switzerland.

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http://dx.doi.org/10.1038/nature14387DOI Listing
April 2015

Defining the biology component of the drug discovery strategy for malaria eradication.

Trends Parasitol 2014 Oct 15;30(10):478-90. Epub 2014 Aug 15.

Medicines for Malaria Venture (MMV), PO Box 1826, 20 route de Pré-Bois, 1215 Geneva 15, Switzerland.

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http://dx.doi.org/10.1016/j.pt.2014.07.004DOI Listing
October 2014

Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors.

J Med Chem 2014 Jun 13;57(12):5381-94. Epub 2014 Jun 13.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas , 6001 Forest Park Boulevard, Dallas, Texas 75390-9041, United States.

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http://dx.doi.org/10.1021/jm500481tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079327PMC
June 2014

Antimalarial drug discovery - the path towards eradication.

Parasitology 2014 Jan 17;141(1):128-39. Epub 2013 Jul 17.

Medicines for Malaria Venture, ICC, 20 Route de Pré-Bois - PO Box 1826, 1215 Geneva 15, Switzerland.

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http://www.journals.cambridge.org/abstract_S0031182013000826
Publisher Site
http://dx.doi.org/10.1017/S0031182013000826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884835PMC
January 2014

Designing the next generation of medicines for malaria control and eradication.

Malar J 2013 Jun 6;12:187. Epub 2013 Jun 6.

Medicines for Malaria Venture-MMV, PO Box 1826, Route de Pré-Bois 20, Geneva 151215, Switzerland.

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http://dx.doi.org/10.1186/1475-2875-12-187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685552PMC
June 2013

Antimalarial drug discovery: where next?

Authors:
Jeremy N Burrows

Future Med Chem 2012 Dec;4(18):2233-5

Medicines for Malaria Venture, PO Box 1826, 20 route de Pré-Bois, 1215 Geneva 15, Switzerland.

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http://dx.doi.org/10.4155/fmc.12.189DOI Listing
December 2012

The global pipeline of new medicines for the control and elimination of malaria.

Malar J 2012 Sep 7;11:316. Epub 2012 Sep 7.

Medicines for Malaria Venture (MMV), 20 rte de Pré-Bois 1215, Geneva, Switzerland.

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http://dx.doi.org/10.1186/1475-2875-11-316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472257PMC
September 2012

Identification and In-Vitro ADME Assessment of a Series of Novel Anti-Malarial Agents Suitable for Hit-to-Lead Chemistry.

ACS Med Chem Lett 2012 Jul 28;3(7):570-3. Epub 2012 May 28.

Medical Research Council Technology , 1-3 Burtonhole Lane, Mill Hill, London, United Kingdom.

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http://dx.doi.org/10.1021/ml300091cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025777PMC
July 2012

Novel orally active antimalarial thiazoles.

J Med Chem 2011 Nov 11;54(21):7713-9. Epub 2011 Oct 11.

Department of Chemistry, University of Cape Town , Rondebosch 7701, South Africa.

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http://dx.doi.org/10.1021/jm201108kDOI Listing
November 2011

Challenges in antimalarial drug discovery.

Future Med Chem 2011 Sep;3(11):1401-12

Medicines for Malaria Venture, Route de Pré-Bois 20, PO Box 1826, 1215 Geneva 15, Switzerland.

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http://dx.doi.org/10.4155/fmc.11.91DOI Listing
September 2011

The state of the art in anti-malarial drug discovery and development.

Curr Top Med Chem 2011 ;11(10):1226-54

Medicines for Malaria Venture, ICC, Geneva, Switzerland.

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http://dx.doi.org/10.2174/156802611795429194DOI Listing
August 2011

The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis.

Bioorg Med Chem Lett 2011 Mar 18;21(5):1376-81. Epub 2011 Jan 18.

Respiratory and Inflammation Research Area, AstraZeneca, Alderley Park, Macclesfield, Cheshire, UK.

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http://dx.doi.org/10.1016/j.bmcl.2011.01.036DOI Listing
March 2011

Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity.

J Med Chem 2010 Oct;53(19):7076-94

Department of Chemistry, University of South Florida, CHE 205, 4202 E. Fowler Avenue, Tampa, Florida 33620, USA.

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http://dx.doi.org/10.1021/jm1007903DOI Listing
October 2010

Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination.

Trends Parasitol 2010 Mar 3;26(3):145-51. Epub 2010 Feb 3.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://linkinghub.elsevier.com/retrieve/pii/S147149220900280
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http://dx.doi.org/10.1016/j.pt.2009.12.005DOI Listing
March 2010

Concise syntheses of the natural products (+)-sylvaticin and (+)-cis-sylvaticin.

J Am Chem Soc 2009 Sep;131(35):12854-61

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1021/ja9049959DOI Listing
September 2009

ProSAR: a new methodology for combinatorial library design.

J Chem Inf Model 2009 Mar;49(3):603-14

DECS GCS Computational Chemistry, AstraZeneca R&D Mölndal, Pepparedsleden 1, SE-43183 Mölndal, Sweden.

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http://dx.doi.org/10.1021/ci800231dDOI Listing
March 2009

Studies on the total synthesis of lactonamycin: synthesis of the CDEF ring system.

J Org Chem 2006 Oct;71(21):8151-8

Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, England.

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http://pubs.acs.org/doi/abs/10.1021/jo0613378
Publisher Site
http://dx.doi.org/10.1021/jo0613378DOI Listing
October 2006

Total synthesis of (+)-cis-sylvaticin: double oxidative cyclization reactions catalyzed by osmium.

J Am Chem Soc 2006 Oct;128(42):13704-5

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, UK.

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http://dx.doi.org/10.1021/ja0660148DOI Listing
October 2006

Fragment screening: an introduction.

Mol Biosyst 2006 Sep;2(9):430-46

GlaxoSmithKline Research and Development, Gunnels Wood Road, Stevenage, Herts, UK.

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http://dx.doi.org/10.1039/b610069bDOI Listing
September 2006

New osmium-based reagent for the dihydroxylation of alkenes.

J Org Chem 2006 Jun;71(12):4481-9

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1021/jo060301cDOI Listing
June 2006

Studies on the total synthesis of lactonamycin: construction of model ABCD ring systems.

J Org Chem 2006 Mar;71(6):2434-44

Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, England.

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http://dx.doi.org/10.1021/jo052637cDOI Listing
March 2006

Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas.

Bioorg Med Chem Lett 2005 Jan;15(1):25-8

Respiratory and Inflammation Research Area, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK.

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http://dx.doi.org/10.1016/j.bmcl.2004.10.044DOI Listing
January 2005