Publications by authors named "Jeremy A Goettel"

26Publications

Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation.

Gastroenterology 2020 Aug 21. Epub 2020 Aug 21.

Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee; Program in Chemical and Physical Biology, Vanderbilt University, Nashville, Tennessee; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, Tennessee; Center for Quantitative Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2020.08.029DOI Listing
August 2020

Humanized mouse models of genetic immune disorders and hematological malignancies.

Biochem Pharmacol 2020 04 18;174:113671. Epub 2019 Oct 18.

Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2019.113671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050416PMC
April 2020

Low-Dose Interleukin-2 Ameliorates Colitis in a Preclinical Humanized Mouse Model.

Cell Mol Gastroenterol Hepatol 2019 9;8(2):193-195. Epub 2019 May 9.

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2019.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661391PMC
July 2020

Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD.

Inflamm Bowel Dis 2017 11;23(11):1950-1961

1Division of Pediatric Gastroenterology and Nutrition, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat-Gan, Israel; 2Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; 3Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts; 4VEO-IBD Consortium; 5Department of Pediatrics and Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts; 6Harvard Medical School, Boston, Massachusetts; 7Great Ormond Street Hospital London, London, England; 8Translational Gastroenterology Unit, University of Oxford, Oxford, England; 9Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, Gainesville, Florida; 10Division of Gastroenterology and Nutrition, The Children's Hospital at Montefiore, Bronx, New York; 11Pediatric Gastroenterology Unit, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel; 12Department of Pediatrics, Kurume University School of Medicine, Kurume, Japan; 13Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany; 14Department of Gastroenterology, Children's National Medical Center, Washington, DC; 15Division of Pediatric Hematology and Oncology, University of Michigan, Ann Arbor, Michigan; 16Hospital das Clınicas, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 17Division of Gastroenterology, McMaster Children's Hospital, West Hamilton, Ontario, Canada; 18Dr von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany; 19Division of Pathology, Boston Children's Hospital, Boston, Massachusetts; 20Department of Pediatrics, University of Oxford, Oxford, England; 21Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; 22Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada; 23Department of Biochemistry, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; and 24Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1097/MIB.0000000000001270DOI Listing
November 2017

Haematopoietic stem and progenitor cells from human pluripotent stem cells.

Nature 2017 05 17;545(7655):432-438. Epub 2017 May 17.

Stem Cell Transplantation Program, Division of Pediatric Hematology and Oncology, Dana-Farber Cancer Institute, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature22370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872146PMC
May 2017

Ultrasound-Mediated Delivery of RNA to Colonic Mucosa of Live Mice.

Gastroenterology 2017 04 11;152(5):1151-1160. Epub 2017 Jan 11.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts; The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368009PMC
April 2017

Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia.

Proc Natl Acad Sci U S A 2017 01 3;114(3):568-573. Epub 2017 Jan 3.

Department of Gastroenterology, Nutrition, and Hepatology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.

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http://dx.doi.org/10.1073/pnas.1612921114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5255594PMC
January 2017

AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice.

Cell Rep 2016 10;17(5):1318-1329

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA; The Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.09.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106873PMC
October 2016

Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.

Blood 2015 Jun 1;125(25):3886-95. Epub 2015 Apr 1.

Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA; Department of Medicine, Harvard Medical School, Boston, MA; Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1182/blood-2014-12-618363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473116PMC
June 2015

Aminoglycoside-mediated relaxation of the ductus arteriosus in sepsis-associated PDA.

Am J Physiol Heart Circ Physiol 2014 Sep 3;307(5):H732-40. Epub 2014 Jul 3.

Department of Pediatrics, Vanderbilt University School of Medicine and the Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee;

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http://www.physiology.org/doi/10.1152/ajpheart.00838.2013
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http://dx.doi.org/10.1152/ajpheart.00838.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187398PMC
September 2014

Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function.

Immunity 2014 May 1;40(5):706-19. Epub 2014 May 1.

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA 02115, USA; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS). Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513358PMC
May 2014

Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans.

Adv Immunol 2014 ;122:177-210

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Division of Gastroenterology, Brigham & Women's Hospital, Boston, Massachusetts, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/B97801280026740
Publisher Site
http://dx.doi.org/10.1016/B978-0-12-800267-4.00005-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741283PMC
May 2014

Colitis and colon cancer in WASP-deficient mice require helicobacter species.

Inflamm Bowel Dis 2013 Sep;19(10):2041-50

Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02139, USA.

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http://dx.doi.org/10.1097/MIB.0b013e318295fd8fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082694PMC
September 2013

Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice.

Gastroenterology 2012 Sep 15;143(3):719-729.e2. Epub 2012 Jun 15.

Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Department of Gastroenterology/Nutrition, Children's Hospital, Boston, Massachusetts; Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2012.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760724PMC
September 2012

Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratios.

Gut 2013 Jan 20;62(1):73-82. Epub 2012 Jan 20.

Division of Neonatology, Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, 2215 B Garland Ave., 1125 MRB IV/Light Hall, Nashville, TN 37232-0656, USA.

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http://dx.doi.org/10.1136/gutjnl-2011-301551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606820PMC
January 2013

TNF transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells.

Am J Physiol Gastrointest Liver Physiol 2011 Aug 12;301(2):G220-9. Epub 2011 May 12.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1152/ajpgi.00383.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154604PMC
August 2011

Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections.

Nat Med 2011 Mar 6;17(3):341-6. Epub 2011 Feb 6.

Department of Molecular Biology, University of Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1038/nm.2296DOI Listing
March 2011

KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1.

Exp Cell Res 2011 Feb 7;317(4):452-63. Epub 2010 Dec 7.

Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1016/j.yexcr.2010.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038243PMC
February 2011

KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-γ production.

Gastroenterology 2011 Jan 25;140(1):265-74. Epub 2010 Sep 25.

Department of Cell and Developmental Biology, Vanderbilt University School of Medicine and Monroe Carell Jr Children's Hospital at Vanderbilt, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1053/j.gastro.2010.09.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008308PMC
January 2011

TNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB.

J Biol Chem 2008 Oct 18;283(43):29485-94. Epub 2008 Aug 18.

Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0696, USA.

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http://dx.doi.org/10.1074/jbc.M801269200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570867PMC
October 2008

Tumor necrosis factor inhibits ligand-stimulated EGF receptor activation through a TNF receptor 1-dependent mechanism.

Am J Physiol Gastrointest Liver Physiol 2008 Aug 8;295(2):G285-93. Epub 2008 May 8.

Dept. of Pediatrics, Div. of Pediatric Gastroenterology, Hepatology, and Nutrition, 2215 Garland Ave., 1035 MRB IV, Nashville TN, 37232-0696, USA.

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http://dx.doi.org/10.1152/ajpgi.00425.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519857PMC
August 2008