Jens Treutlein

Jens Treutlein

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Jens Treutlein

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Genome-wide association study identifies 30 loci associated with bipolar disorder.

Authors:
Eli A Stahl Gerome Breen Andreas J Forstner Andrew McQuillin Stephan Ripke Vassily Trubetskoy Manuel Mattheisen Yunpeng Wang Jonathan R I Coleman Héléna A Gaspar Christiaan A de Leeuw Stacy Steinberg Jennifer M Whitehead Pavlides Maciej Trzaskowski Enda M Byrne Tune H Pers Peter A Holmans Alexander L Richards Liam Abbott Esben Agerbo Huda Akil Diego Albani Ney Alliey-Rodriguez Thomas D Als Adebayo Anjorin Verneri Antilla Swapnil Awasthi Judith A Badner Marie Bækvad-Hansen Jack D Barchas Nicholas Bass Michael Bauer Richard Belliveau Sarah E Bergen Carsten Bøcker Pedersen Erlend Bøen Marco P Boks James Boocock Monika Budde William Bunney Margit Burmeister Jonas Bybjerg-Grauholm William Byerley Miquel Casas Felecia Cerrato Pablo Cervantes Kimberly Chambert Alexander W Charney Danfeng Chen Claire Churchhouse Toni-Kim Clarke William Coryell David W Craig Cristiana Cruceanu David Curtis Piotr M Czerski Anders M Dale Simone de Jong Franziska Degenhardt Jurgen Del-Favero J Raymond DePaulo Srdjan Djurovic Amanda L Dobbyn Ashley Dumont Torbjørn Elvsåshagen Valentina Escott-Price Chun Chieh Fan Sascha B Fischer Matthew Flickinger Tatiana M Foroud Liz Forty Josef Frank Christine Fraser Nelson B Freimer Louise Frisén Katrin Gade Diane Gage Julie Garnham Claudia Giambartolomei Marianne Giørtz Pedersen Jaqueline Goldstein Scott D Gordon Katherine Gordon-Smith Elaine K Green Melissa J Green Tiffany A Greenwood Jakob Grove Weihua Guan José Guzman-Parra Marian L Hamshere Martin Hautzinger Urs Heilbronner Stefan Herms Maria Hipolito Per Hoffmann Dominic Holland Laura Huckins Stéphane Jamain Jessica S Johnson Anders Juréus Radhika Kandaswamy Robert Karlsson James L Kennedy Sarah Kittel-Schneider James A Knowles Manolis Kogevinas Anna C Koller Ralph Kupka Catharina Lavebratt Jacob Lawrence William B Lawson Markus Leber Phil H Lee Shawn E Levy Jun Z Li Chunyu Liu Susanne Lucae Anna Maaser Donald J MacIntyre Pamela B Mahon Wolfgang Maier Lina Martinsson Steve McCarroll Peter McGuffin Melvin G McInnis James D McKay Helena Medeiros Sarah E Medland Fan Meng Lili Milani Grant W Montgomery Derek W Morris Thomas W Mühleisen Niamh Mullins Hoang Nguyen Caroline M Nievergelt Annelie Nordin Adolfsson Evaristus A Nwulia Claire O'Donovan Loes M Olde Loohuis Anil P S Ori Lilijana Oruc Urban Ösby Roy H Perlis Amy Perry Andrea Pfennig James B Potash Shaun M Purcell Eline J Regeer Andreas Reif Céline S Reinbold John P Rice Fabio Rivas Margarita Rivera Panos Roussos Douglas M Ruderfer Euijung Ryu Cristina Sánchez-Mora Alan F Schatzberg William A Scheftner Nicholas J Schork Cynthia Shannon Weickert Tatyana Shehktman Paul D Shilling Engilbert Sigurdsson Claire Slaney Olav B Smeland Janet L Sobell Christine Søholm Hansen Anne T Spijker David St Clair Michael Steffens John S Strauss Fabian Streit Jana Strohmaier Szabolcs Szelinger Robert C Thompson Thorgeir E Thorgeirsson Jens Treutlein Helmut Vedder Weiqing Wang Stanley J Watson Thomas W Weickert Stephanie H Witt Simon Xi Wei Xu Allan H Young Peter Zandi Peng Zhang Sebastian Zöllner Rolf Adolfsson Ingrid Agartz Martin Alda Lena Backlund Bernhard T Baune Frank Bellivier Wade H Berrettini Joanna M Biernacka Douglas H R Blackwood Michael Boehnke Anders D Børglum Aiden Corvin Nicholas Craddock Mark J Daly Udo Dannlowski Tõnu Esko Bruno Etain Mark Frye Janice M Fullerton Elliot S Gershon Michael Gill Fernando Goes Maria Grigoroiu-Serbanescu Joanna Hauser David M Hougaard Christina M Hultman Ian Jones Lisa A Jones René S Kahn George Kirov Mikael Landén Marion Leboyer Cathryn M Lewis Qingqin S Li Jolanta Lissowska Nicholas G Martin Fermin Mayoral Susan L McElroy Andrew M McIntosh Francis J McMahon Ingrid Melle Andres Metspalu Philip B Mitchell Gunnar Morken Ole Mors Preben Bo Mortensen Bertram Müller-Myhsok Richard M Myers Benjamin M Neale Vishwajit Nimgaonkar Merete Nordentoft Markus M Nöthen Michael C O'Donovan Ketil J Oedegaard Michael J Owen Sara A Paciga Carlos Pato Michele T Pato Danielle Posthuma Josep Antoni Ramos-Quiroga Marta Ribasés Marcella Rietschel Guy A Rouleau Martin Schalling Peter R Schofield Thomas G Schulze Alessandro Serretti Jordan W Smoller Hreinn Stefansson Kari Stefansson Eystein Stordal Patrick F Sullivan Gustavo Turecki Arne E Vaaler Eduard Vieta John B Vincent Thomas Werge John I Nurnberger Naomi R Wray Arianna Di Florio Howard J Edenberg Sven Cichon Roel A Ophoff Laura J Scott Ole A Andreassen John Kelsoe Pamela Sklar

Nat Genet 2019 05 1;51(5):793-803. Epub 2019 May 1.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://www.nature.com/articles/s41588-019-0397-8
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http://dx.doi.org/10.1038/s41588-019-0397-8DOI Listing
May 2019

Association of the alcohol dehydrogenase gene polymorphism rs1789891 with gray matter brain volume, alcohol consumption, alcohol craving and relapse risk.

Addict Biol 2019 Jan 23;24(1):110-120. Epub 2017 Oct 23.

Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.

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http://dx.doi.org/10.1111/adb.12571DOI Listing
January 2019

Evidence for increased genetic risk load for major depression in patients assigned to electroconvulsive therapy.

Am J Med Genet B Neuropsychiatr Genet 2019 Jan 2;180(1):35-45. Epub 2018 Dec 2.

Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1002/ajmg.b.32700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368636PMC
January 2019

Response to therapeutic sleep deprivation: a naturalistic study of clinical and genetic factors and post-treatment depressive symptom trajectory.

Neuropsychopharmacology 2018 12 17;43(13):2572-2577. Epub 2018 May 17.

Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, University of Heidelberg, J5 68159, Mannheim, Germany.

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http://dx.doi.org/10.1038/s41386-018-0092-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224527PMC
December 2018

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.

Authors:
Raymond K Walters Renato Polimanti Emma C Johnson Jeanette N McClintick Mark J Adams Amy E Adkins Fazil Aliev Silviu-Alin Bacanu Anthony Batzler Sarah Bertelsen Joanna M Biernacka Tim B Bigdeli Li-Shiun Chen Toni-Kim Clarke Yi-Ling Chou Franziska Degenhardt Anna R Docherty Alexis C Edwards Pierre Fontanillas Jerome C Foo Louis Fox Josef Frank Ina Giegling Scott Gordon Laura M Hack Annette M Hartmann Sarah M Hartz Stefanie Heilmann-Heimbach Stefan Herms Colin Hodgkinson Per Hoffmann Jouke Jan Hottenga Martin A Kennedy Mervi Alanne-Kinnunen Bettina Konte Jari Lahti Marius Lahti-Pulkkinen Dongbing Lai Lannie Ligthart Anu Loukola Brion S Maher Hamdi Mbarek Andrew M McIntosh Matthew B McQueen Jacquelyn L Meyers Yuri Milaneschi Teemu Palviainen John F Pearson Roseann E Peterson Samuli Ripatti Euijung Ryu Nancy L Saccone Jessica E Salvatore Sandra Sanchez-Roige Melanie Schwandt Richard Sherva Fabian Streit Jana Strohmaier Nathaniel Thomas Jen-Chyong Wang Bradley T Webb Robbee Wedow Leah Wetherill Amanda G Wills Jason D Boardman Danfeng Chen Doo-Sup Choi William E Copeland Robert C Culverhouse Norbert Dahmen Louisa Degenhardt Benjamin W Domingue Sarah L Elson Mark A Frye Wolfgang Gäbel Caroline Hayward Marcus Ising Margaret Keyes Falk Kiefer John Kramer Samuel Kuperman Susanne Lucae Michael T Lynskey Wolfgang Maier Karl Mann Satu Männistö Bertram Müller-Myhsok Alison D Murray John I Nurnberger Aarno Palotie Ulrich Preuss Katri Räikkönen Maureen D Reynolds Monika Ridinger Norbert Scherbaum Marc A Schuckit Michael Soyka Jens Treutlein Stephanie Witt Norbert Wodarz Peter Zill Daniel E Adkins Joseph M Boden Dorret I Boomsma Laura J Bierut Sandra A Brown Kathleen K Bucholz Sven Cichon E Jane Costello Harriet de Wit Nancy Diazgranados Danielle M Dick Johan G Eriksson Lindsay A Farrer Tatiana M Foroud Nathan A Gillespie Alison M Goate David Goldman Richard A Grucza Dana B Hancock Kathleen Mullan Harris Andrew C Heath Victor Hesselbrock John K Hewitt Christian J Hopfer John Horwood William Iacono Eric O Johnson Jaakko A Kaprio Victor M Karpyak Kenneth S Kendler Henry R Kranzler Kenneth Krauter Paul Lichtenstein Penelope A Lind Matt McGue James MacKillop Pamela A F Madden Hermine H Maes Patrik Magnusson Nicholas G Martin Sarah E Medland Grant W Montgomery Elliot C Nelson Markus M Nöthen Abraham A Palmer Nancy L Pedersen Brenda W J H Penninx Bernice Porjesz John P Rice Marcella Rietschel Brien P Riley Richard Rose Dan Rujescu Pei-Hong Shen Judy Silberg Michael C Stallings Ralph E Tarter Michael M Vanyukov Scott Vrieze Tamara L Wall John B Whitfield Hongyu Zhao Benjamin M Neale Joel Gelernter Howard J Edenberg Arpana Agrawal

Nat Neurosci 2018 12 26;21(12):1656-1669. Epub 2018 Nov 26.

Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.

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http://dx.doi.org/10.1038/s41593-018-0275-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430207PMC
December 2018

Response to therapeutic sleep deprivation: a naturalistic study of clinical and genetic factors and post-treatment depressive symptom trajectory.

Neuropsychopharmacology 2018 12 17;43(13):2572-2577. Epub 2018 May 17.

Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, University of Heidelberg, J5 68159, Mannheim, Germany.

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http://dx.doi.org/10.1038/s41386-018-0092-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224527PMC
December 2018

Gene set enrichment analysis and expression pattern exploration implicate an involvement of neurodevelopmental processes in bipolar disorder.

J Affect Disord 2018 03 14;228:20-25. Epub 2017 Nov 14.

Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany; Department of Biomedicine & Institute of Medical Genetics and Pathology, Human Genomics Research Group and Division of Medical Genetics, Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland; Institute of Human Genetics, Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany; Department of Genomics, Life & Brain Research Center, University of Bonn, Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2017.11.068DOI Listing
March 2018

Fast sleep spindle density is associated with rs4680 (Val108/158Met) genotype of catechol-O-methyltransferase (COMT).

Sleep 2018 03;41(3)

Central Institute of Mental Health, Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1093/sleep/zsy007DOI Listing
March 2018

Preliminary Evidence for an Association Between Variants of the Catechol-O-Methyltransferase (COMT) Gene and Premature Ejaculation.

J Sex Med 2017 12;14(12):1558-1565

Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Germany.

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http://dx.doi.org/10.1016/j.jsxm.2017.11.002DOI Listing
December 2017

Expert and self-assessment of lifetime symptoms and diagnosis of major depressive disorder in large-scale genetic studies in the general population: comparison of a clinical interview and a self-administered checklist.

Psychiatr Genet 2017 10;27(5):187-196

aDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim bInstitute of Human Genetics cDepartment of Genomics, Life and Brain Center, University of Bonn, Bonn dInstitute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University, Munich eDepartment of Psychiatry and Psychotherapy, University of Göttingen, Göttingen fInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany gDepartment of Biomedicine, Division of Medical Genetics, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1097/YPG.0000000000000182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576521PMC
October 2017

Identification of shared risk loci and pathways for bipolar disorder and schizophrenia.

PLoS One 2017 6;12(2):e0171595. Epub 2017 Feb 6.

Institute of Human Genetics, University of Bonn, Bonn, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171595PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293228PMC
August 2017

Association between neuropeptide Y receptor Y2 promoter variant rs6857715 and major depressive disorder.

Psychiatr Genet 2017 02;27(1):34-37

aDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg bInstitute of Human Genetics, University of Bonn, Bonn, Germany cDepartment of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany d Department of Child and Adolescent Psychiatry, University Psychiatric Hospital, Bern, Switzerland eDepartment of Biomedicine, Division of Medical Genetics, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1097/YPG.0000000000000149DOI Listing
February 2017

GATA4 variant interaction with brain limbic structure and relapse risk: A voxel-based morphometry study.

Eur Neuropsychopharmacol 2016 09 7;26(9):1431-1437. Epub 2016 Jul 7.

Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1016/j.euroneuro.2016.06.011DOI Listing
September 2016

Interaction between COMT Val(158)Met polymorphism and childhood adversity affects reward processing in adulthood.

Neuroimage 2016 05 12;132:556-570. Epub 2016 Feb 12.

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany; Department of Psychology, University of Potsdam, Potsdam, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuroimage.2016.02.006DOI Listing
May 2016

Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.

Authors:
Tae-Hwi Schwantes-An Juan Zhang Li-Shiun Chen Sarah M Hartz Robert C Culverhouse Xiangning Chen Hilary Coon Josef Frank Helen M Kamens Bettina Konte Leena Kovanen Antti Latvala Lisa N Legrand Brion S Maher Whitney E Melroy Elliot C Nelson Mark W Reid Jason D Robinson Pei-Hong Shen Bao-Zhu Yang Judy A Andrews Paul Aveyard Olga Beltcheva Sandra A Brown Dale S Cannon Sven Cichon Robin P Corley Norbert Dahmen Louisa Degenhardt Tatiana Foroud Wolfgang Gaebel Ina Giegling Stephen J Glatt Richard A Grucza Jill Hardin Annette M Hartmann Andrew C Heath Stefan Herms Colin A Hodgkinson Per Hoffmann Hyman Hops David Huizinga Marcus Ising Eric O Johnson Elaine Johnstone Radka P Kaneva Kenneth S Kendler Falk Kiefer Henry R Kranzler Ken S Krauter Orna Levran Susanne Lucae Michael T Lynskey Wolfgang Maier Karl Mann Nicholas G Martin Manuel Mattheisen Grant W Montgomery Bertram Müller-Myhsok Michael F Murphy Michael C Neale Momchil A Nikolov Denise Nishita Markus M Nöthen John Nurnberger Timo Partonen Michele L Pergadia Maureen Reynolds Monika Ridinger Richard J Rose Noora Rouvinen-Lagerström Norbert Scherbaum Christine Schmäl Michael Soyka Michael C Stallings Michael Steffens Jens Treutlein Ming Tsuang Tamara L Wall Norbert Wodarz Vadim Yuferov Peter Zill Andrew W Bergen Jingchun Chen Paul M Cinciripini Howard J Edenberg Marissa A Ehringer Robert E Ferrell Joel Gelernter David Goldman John K Hewitt Christian J Hopfer William G Iacono Jaakko Kaprio Mary Jeanne Kreek Ivo M Kremensky Pamela A F Madden Matt McGue Marcus R Munafò Robert A Philibert Marcella Rietschel Alec Roy Dan Rujescu Sirkku T Saarikoski Gary E Swan Alexandre A Todorov Michael M Vanyukov Robert B Weiss Laura J Bierut Nancy L Saccone

Behav Genet 2016 Mar 21;46(2):151-69. Epub 2015 Sep 21.

Department of Genetics, Washington University School of Medicine, 4523 Clayton Avenue, Campus Box 8232, St. Louis, MO, 63110, USA.

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https://genepi.qimr.edu.au/contents/p/staff/Schwantes_An_Beh
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http://link.springer.com/10.1007/s10519-015-9737-3
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http://dx.doi.org/10.1007/s10519-015-9737-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752855PMC
March 2016

A common risk variant in CACNA1C supports a sex-dependent effect on longitudinal functioning and functional recovery from episodes of schizophrenia-spectrum but not bipolar disorder.

Eur Neuropsychopharmacol 2015 Dec 9;25(12):2262-70. Epub 2015 Oct 9.

Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Germany; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany; Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August-University, Göttingen, Germany.

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http://dx.doi.org/10.1016/j.euroneuro.2015.09.012DOI Listing
December 2015

Alterations of Glucocorticoid Receptor Gene Methylation in Externalizing Disorders During Childhood and Adolescence.

Behav Genet 2015 Sep 18;45(5):529-36. Epub 2015 Apr 18.

Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany,

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http://dx.doi.org/10.1007/s10519-015-9721-yDOI Listing
September 2015

New-born females show higher stress- and genotype-independent methylation of SLC6A4 than males.

Borderline Personal Disord Emot Dysregul 2015 15;2. Epub 2015 Apr 15.

Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1186/s40479-015-0029-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579500PMC
September 2015

Genetic variation in the G72 gene is associated with increased frontotemporal fiber tract integrity.

Eur Arch Psychiatry Clin Neurosci 2015 Jun 17;265(4):291-301. Epub 2014 Jul 17.

Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstrasse-30, 52074, Aachen, Germany,

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http://dx.doi.org/10.1007/s00406-014-0516-6DOI Listing
June 2015

Association of norepinephrine transporter (NET, SLC6A2) genotype with ADHD-related phenotypes: findings of a longitudinal study from birth to adolescence.

Psychiatry Res 2015 Apr 27;226(2-3):425-33. Epub 2014 Dec 27.

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany; Department of Psychology, University of Potsdam, Potsdam, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.psychres.2014.12.029DOI Listing
April 2015

Smoking behaviour: investigation of the coaction of environmental and genetic risk factors.

Psychiatr Genet 2014 Dec;24(6):279-80

aDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim bInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich cInstitute of Human Genetics dDepartment of Genomics, Life & Brain Center, University of Bonn, Bonn eSection on Psychiatric Genetics, Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany fDepartment of Biomedicine, Division of Medical Genetics, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1097/YPG.0000000000000051DOI Listing
December 2014

Analysis of genome-wide significant bipolar disorder genes in borderline personality disorder.

Psychiatr Genet 2014 Dec;24(6):262-5

Departments of aGenetic Epidemiology in Psychiatry bPsychosomatic Medicine and Psychotherapy cBiostatistics, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim dDepartment of Genomics, Institute of Human Genetics, Life and Brain Center University of Bonn, Bonn eDepartment of Psychiatry and Psychotherapy, University Medical Center, Mainz fLeibniz Institute for Neurobiology, Magdeburg gDepartment of Psychiatry, Campus Mitte hDepartment of Psychiatry, Campus Benjamin Franklin, Charité-Universitätsmedizin, Berlin iDepartment of Psychiatry, University of Halle, Halle, Germany jDepartment of Biomedicine, Division of Medical Genetics, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1097/YPG.0000000000000060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219535PMC
December 2014

Interaction between prenatal stress and dopamine D4 receptor genotype in predicting aggression and cortisol levels in young adults.

Psychopharmacology (Berl) 2014 Aug 20;231(16):3089-97. Epub 2014 Feb 20.

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J 5, 68159, Mannheim, Germany.

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http://link.springer.com/content/pdf/10.1007/s00213-014-3484
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http://link.springer.com/10.1007/s00213-014-3484-7
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http://dx.doi.org/10.1007/s00213-014-3484-7DOI Listing
August 2014

A functional variant in the neuropeptide S receptor 1 gene moderates the influence of urban upbringing on stress processing in the amygdala.

Stress 2014 Jul 16;17(4):352-61. Epub 2014 Jun 16.

Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg , Mannheim , Germany .

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http://dx.doi.org/10.3109/10253890.2014.921903DOI Listing
July 2014

ADH1B Arg48His allele frequency map: filling in the gap for Central Europe.

Biol Psychiatry 2014 May 5;75(10):e15. Epub 2013 Sep 5.

Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2013.05.042DOI Listing
May 2014

Genome-wide association study reveals two new risk loci for bipolar disorder.

Nat Commun 2014 Mar 11;5:3339. Epub 2014 Mar 11.

1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany [3] Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, D-52425 Jülich, Germany [4] Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel CH-4012, Switzerland [5].

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http://www.nature.com/articles/ncomms4339
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http://dx.doi.org/10.1038/ncomms4339DOI Listing
March 2014

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.

Authors:
S Hong Lee Stephan Ripke Benjamin M Neale Stephen V Faraone Shaun M Purcell Roy H Perlis Bryan J Mowry Anita Thapar Michael E Goddard John S Witte Devin Absher Ingrid Agartz Huda Akil Farooq Amin Ole A Andreassen Adebayo Anjorin Richard Anney Verneri Anttila Dan E Arking Philip Asherson Maria H Azevedo Lena Backlund Judith A Badner Anthony J Bailey Tobias Banaschewski Jack D Barchas Michael R Barnes Thomas B Barrett Nicholas Bass Agatino Battaglia Michael Bauer Mònica Bayés Frank Bellivier Sarah E Bergen Wade Berrettini Catalina Betancur Thomas Bettecken Joseph Biederman Elisabeth B Binder Donald W Black Douglas H R Blackwood Cinnamon S Bloss Michael Boehnke Dorret I Boomsma Gerome Breen René Breuer Richard Bruggeman Paul Cormican Nancy G Buccola Jan K Buitelaar William E Bunney Joseph D Buxbaum William F Byerley Enda M Byrne Sian Caesar Wiepke Cahn Rita M Cantor Miguel Casas Aravinda Chakravarti Kimberly Chambert Khalid Choudhury Sven Cichon C Robert Cloninger David A Collier Edwin H Cook Hilary Coon Bru Cormand Aiden Corvin William H Coryell David W Craig Ian W Craig Jennifer Crosbie Michael L Cuccaro David Curtis Darina Czamara Susmita Datta Geraldine Dawson Richard Day Eco J De Geus Franziska Degenhardt Srdjan Djurovic Gary J Donohoe Alysa E Doyle Jubao Duan Frank Dudbridge Eftichia Duketis Richard P Ebstein Howard J Edenberg Josephine Elia Sean Ennis Bruno Etain Ayman Fanous Anne E Farmer I Nicol Ferrier Matthew Flickinger Eric Fombonne Tatiana Foroud Josef Frank Barbara Franke Christine Fraser Robert Freedman Nelson B Freimer Christine M Freitag Marion Friedl Louise Frisén Louise Gallagher Pablo V Gejman Lyudmila Georgieva Elliot S Gershon Daniel H Geschwind Ina Giegling Michael Gill Scott D Gordon Katherine Gordon-Smith Elaine K Green Tiffany A Greenwood Dorothy E Grice Magdalena Gross Detelina Grozeva Weihua Guan Hugh Gurling Lieuwe De Haan Jonathan L Haines Hakon Hakonarson Joachim Hallmayer Steven P Hamilton Marian L Hamshere Thomas F Hansen Annette M Hartmann Martin Hautzinger Andrew C Heath Anjali K Henders Stefan Herms Ian B Hickie Maria Hipolito Susanne Hoefels Peter A Holmans Florian Holsboer Witte J Hoogendijk Jouke-Jan Hottenga Christina M Hultman Vanessa Hus Andrés Ingason Marcus Ising Stéphane Jamain Edward G Jones Ian Jones Lisa Jones Jung-Ying Tzeng Anna K Kähler René S Kahn Radhika Kandaswamy Matthew C Keller James L Kennedy Elaine Kenny Lindsey Kent Yunjung Kim George K Kirov Sabine M Klauck Lambertus Klei James A Knowles Martin A Kohli Daniel L Koller Bettina Konte Ania Korszun Lydia Krabbendam Robert Krasucki Jonna Kuntsi Phoenix Kwan Mikael Landén Niklas Långström Mark Lathrop Jacob Lawrence William B Lawson Marion Leboyer David H Ledbetter Phil H Lee Todd Lencz Klaus-Peter Lesch Douglas F Levinson Cathryn M Lewis Jun Li Paul Lichtenstein Jeffrey A Lieberman Dan-Yu Lin Don H Linszen Chunyu Liu Falk W Lohoff Sandra K Loo Catherine Lord Jennifer K Lowe Susanne Lucae Donald J MacIntyre Pamela A F Madden Elena Maestrini Patrik K E Magnusson Pamela B Mahon Wolfgang Maier Anil K Malhotra Shrikant M Mane Christa L Martin Nicholas G Martin Manuel Mattheisen Keith Matthews Morten Mattingsdal Steven A McCarroll Kevin A McGhee James J McGough Patrick J McGrath Peter McGuffin Melvin G McInnis Andrew McIntosh Rebecca McKinney Alan W McLean Francis J McMahon William M McMahon Andrew McQuillin Helena Medeiros Sarah E Medland Sandra Meier Ingrid Melle Fan Meng Jobst Meyer Christel M Middeldorp Lefkos Middleton Vihra Milanova Ana Miranda Anthony P Monaco Grant W Montgomery Jennifer L Moran Daniel Moreno-De-Luca Gunnar Morken Derek W Morris Eric M Morrow Valentina Moskvina Pierandrea Muglia Thomas W Mühleisen Walter J Muir Bertram Müller-Myhsok Michael Murtha Richard M Myers Inez Myin-Germeys Michael C Neale Stan F Nelson Caroline M Nievergelt Ivan Nikolov Vishwajit Nimgaonkar Willem A Nolen Markus M Nöthen John I Nurnberger Evaristus A Nwulia Dale R Nyholt Colm O'Dushlaine Robert D Oades Ann Olincy Guiomar Oliveira Line Olsen Roel A Ophoff Urban Osby Michael J Owen Aarno Palotie Jeremy R Parr Andrew D Paterson Carlos N Pato Michele T Pato Brenda W Penninx Michele L Pergadia Margaret A Pericak-Vance Benjamin S Pickard Jonathan Pimm Joseph Piven Danielle Posthuma James B Potash Fritz Poustka Peter Propping Vinay Puri Digby J Quested Emma M Quinn Josep Antoni Ramos-Quiroga Henrik B Rasmussen Soumya Raychaudhuri Karola Rehnström Andreas Reif Marta Ribasés John P Rice Marcella Rietschel Kathryn Roeder Herbert Roeyers Lizzy Rossin Aribert Rothenberger Guy Rouleau Douglas Ruderfer Dan Rujescu Alan R Sanders Stephan J Sanders Susan L Santangelo Joseph A Sergeant Russell Schachar Martin Schalling Alan F Schatzberg William A Scheftner Gerard D Schellenberg Stephen W Scherer Nicholas J Schork Thomas G Schulze Johannes Schumacher Markus Schwarz Edward Scolnick Laura J Scott Jianxin Shi Paul D Shilling Stanley I Shyn Jeremy M Silverman Susan L Slager Susan L Smalley Johannes H Smit Erin N Smith Edmund J S Sonuga-Barke David St Clair Matthew State Michael Steffens Hans-Christoph Steinhausen John S Strauss Jana Strohmaier T Scott Stroup James S Sutcliffe Peter Szatmari Szabocls Szelinger Srinivasa Thirumalai Robert C Thompson Alexandre A Todorov Federica Tozzi Jens Treutlein Manfred Uhr Edwin J C G van den Oord Gerard Van Grootheest Jim Van Os Astrid M Vicente Veronica J Vieland John B Vincent Peter M Visscher Christopher A Walsh Thomas H Wassink Stanley J Watson Myrna M Weissman Thomas Werge Thomas F Wienker Ellen M Wijsman Gonneke Willemsen Nigel Williams A Jeremy Willsey Stephanie H Witt Wei Xu Allan H Young Timothy W Yu Stanley Zammit Peter P Zandi Peng Zhang Frans G Zitman Sebastian Zöllner Bernie Devlin John R Kelsoe Pamela Sklar Mark J Daly Michael C O'Donovan Nicholas Craddock Patrick F Sullivan Jordan W Smoller Kenneth S Kendler Naomi R Wray

Nat Genet 2013 Sep 11;45(9):984-94. Epub 2013 Aug 11.

The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1038/ng.2711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800159PMC
September 2013

BDNF Val 66 Met and 5-HTTLPR genotype moderate the impact of early psychosocial adversity on plasma brain-derived neurotrophic factor and depressive symptoms: a prospective study.

Eur Neuropsychopharmacol 2013 Aug 9;23(8):902-9. Epub 2012 Oct 9.

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany.

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http://dx.doi.org/10.1016/j.euroneuro.2012.09.003DOI Listing
August 2013

Interactive effects of corticotropin-releasing hormone receptor 1 gene and childhood adversity on depressive symptoms in young adults: findings from a longitudinal study.

Eur Neuropsychopharmacol 2013 May 28;23(5):358-67. Epub 2012 Jun 28.

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.

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http://dx.doi.org/10.1016/j.euroneuro.2012.06.002DOI Listing
May 2013

A mega-analysis of genome-wide association studies for major depressive disorder.

Authors:
Stephan Ripke Naomi R Wray Cathryn M Lewis Steven P Hamilton Myrna M Weissman Gerome Breen Enda M Byrne Douglas H R Blackwood Dorret I Boomsma Sven Cichon Andrew C Heath Florian Holsboer Susanne Lucae Pamela A F Madden Nicholas G Martin Peter McGuffin Pierandrea Muglia Markus M Noethen Brenda P Penninx Michele L Pergadia James B Potash Marcella Rietschel Danyu Lin Bertram Müller-Myhsok Jianxin Shi Stacy Steinberg Hans J Grabe Paul Lichtenstein Patrik Magnusson Roy H Perlis Martin Preisig Jordan W Smoller Kari Stefansson Rudolf Uher Zoltan Kutalik Katherine E Tansey Alexander Teumer Alexander Viktorin Michael R Barnes Thomas Bettecken Elisabeth B Binder René Breuer Victor M Castro Susanne E Churchill William H Coryell Nick Craddock Ian W Craig Darina Czamara Eco J De Geus Franziska Degenhardt Anne E Farmer Maurizio Fava Josef Frank Vivian S Gainer Patience J Gallagher Scott D Gordon Sergey Goryachev Magdalena Gross Michel Guipponi Anjali K Henders Stefan Herms Ian B Hickie Susanne Hoefels Witte Hoogendijk Jouke Jan Hottenga Dan V Iosifescu Marcus Ising Ian Jones Lisa Jones Tzeng Jung-Ying James A Knowles Isaac S Kohane Martin A Kohli Ania Korszun Mikael Landen William B Lawson Glyn Lewis Donald Macintyre Wolfgang Maier Manuel Mattheisen Patrick J McGrath Andrew McIntosh Alan McLean Christel M Middeldorp Lefkos Middleton Grant M Montgomery Shawn N Murphy Matthias Nauck Willem A Nolen Dale R Nyholt Michael O'Donovan Högni Oskarsson Nancy Pedersen William A Scheftner Andrea Schulz Thomas G Schulze Stanley I Shyn Engilbert Sigurdsson Susan L Slager Johannes H Smit Hreinn Stefansson Michael Steffens Thorgeir Thorgeirsson Federica Tozzi Jens Treutlein Manfred Uhr Edwin J C G van den Oord Gerard Van Grootheest Henry Völzke Jeffrey B Weilburg Gonneke Willemsen Frans G Zitman Benjamin Neale Mark Daly Douglas F Levinson Patrick F Sullivan

Mol Psychiatry 2013 Apr 3;18(4):497-511. Epub 2012 Apr 3.

Harvard University/Broad Institute, USA.

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http://dx.doi.org/10.1038/mp.2012.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837431PMC
April 2013

The genetics of alcohol dependence.

Ann N Y Acad Sci 2013 Apr 21;1282:39-70. Epub 2012 Nov 21.

Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health Mannheim, University Medical Center Mannheim, University of Heidelberg, Germany.

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http://dx.doi.org/10.1111/j.1749-6632.2012.06794.xDOI Listing
April 2013

Time-resolved influences of functional DAT1 and COMT variants on visual perception and post-processing.

PLoS One 2012 23;7(7):e41552. Epub 2012 Jul 23.

Section for Clinical Neurophysiology and Multimodal Neuroimaging, Child and Adolescent Psychiatric Department, Technical University Dresden, Dresden, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041552PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402385PMC
November 2012

Dopamine inactivation efficacy related to functional DAT1 and COMT variants influences motor response evaluation.

PLoS One 2012 23;7(5):e37814. Epub 2012 May 23.

Section for Clinical Neurophysiology and Multimodal Neuroimaging, Child and Adolescent Psychiatric Department, Technical University Dresden, Dresden, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037814PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359334PMC
October 2012

An interaction between a neuropeptide Y gene polymorphism and early adversity modulates endocrine stress responses.

Psychoneuroendocrinology 2011 Aug 26;36(7):1010-20. Epub 2011 Jan 26.

Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health Mannheim, J5, 68159 Mannheim, Germany.

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http://dx.doi.org/10.1016/j.psyneuen.2010.12.015DOI Listing
August 2011

Genome-wide association studies of alcohol dependence and substance use disorders.

Curr Psychiatry Rep 2011 Apr;13(2):147-55

Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health Mannheim (CIMH), University of Heidelberg, J5, 68159 Mannheim, Germany.

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http://dx.doi.org/10.1007/s11920-011-0176-4DOI Listing
April 2011

Volition diminishes genetically mediated amygdala hyperreactivity.

Neuroimage 2010 Nov 5;53(3):943-51. Epub 2009 Dec 5.

Department of Psychiatry, Division of Medical Psychology, University of Bonn, Germany.

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http://dx.doi.org/10.1016/j.neuroimage.2009.11.078DOI Listing
November 2010

The effect of G72 genotype on neural correlates of memory encoding and retrieval.

Neuroimage 2010 Nov 11;53(3):1001-6. Epub 2009 Dec 11.

Section of BrainImaging, Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Germany.

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http://dx.doi.org/10.1016/j.neuroimage.2009.12.018DOI Listing
November 2010

The effect of Neuregulin 1 on neural correlates of episodic memory encoding and retrieval.

Neuroimage 2010 Nov 28;53(3):985-91. Epub 2009 Dec 28.

Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Rudolf-Bultmann-Str. 8, 35039 Marburg, Germany.

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http://dx.doi.org/10.1016/j.neuroimage.2009.12.062DOI Listing
November 2010

Interacting effects of CRHR1 gene and stressful life events on drinking initiation and progression among 19-year-olds.

Int J Neuropsychopharmacol 2010 Jul 17;13(6):703-14. Epub 2009 Jul 17.

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany.

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http://dx.doi.org/10.1017/S1461145709990290DOI Listing
July 2010

Prospective association of dopamine-related polymorphisms with smoking cessation in general care.

Pharmacogenomics 2010 Apr;11(4):527-36

Division of Clinical Epidemiology & Aging Research, German Cancer Research Center, Bergheimer Str 20, D-69115 Heidelberg, Germany.

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http://dx.doi.org/10.2217/pgs.10.1DOI Listing
April 2010

Effect of CACNA1C rs1006737 on neural correlates of verbal fluency in healthy individuals.

Neuroimage 2010 Jan 23;49(2):1831-6. Epub 2009 Sep 23.

Department of Psychiatry, Philipps-University Marburg, Rudolf-Bultmann-Str. 8, 35039 Marburg, Germany.

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http://dx.doi.org/10.1016/j.neuroimage.2009.09.028DOI Listing
January 2010

Effect of the G72 (DAOA) putative risk haplotype on cognitive functions in healthy subjects.

BMC Psychiatry 2009 Sep 24;9:60. Epub 2009 Sep 24.

Section of BrainImaging, Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Germany.

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http://dx.doi.org/10.1186/1471-244X-9-60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761379PMC
September 2009

Sex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretion.

Psychoneuroendocrinology 2009 Aug 26;34(7):972-82. Epub 2009 Feb 26.

Department of Theoretical and Clinical Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany.

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http://dx.doi.org/10.1016/j.psyneuen.2009.01.011DOI Listing
August 2009

Genetic variation in dopamine pathways differentially associated with smoking progression in adolescence.

J Am Acad Child Adolesc Psychiatry 2008 Jun;47(6):673-81

Central Institute of Mental Health, Department of Child and Adolescent Psychiatry and Psychotherapy, P.O.Box 122120, D-68072 Mannheim, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S08908567096244
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http://dx.doi.org/10.1097/CHI.0b013e31816bff77DOI Listing
June 2008

HPA-axis activity in alcoholism: examples for a gene-environment interaction.

Addict Biol 2008 Mar 2;13(1):1-14. Epub 2007 Oct 2.

Section of Addiction Biology, Institute of Psychiatry, King's College, London, UK.

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http://dx.doi.org/10.1111/j.1369-1600.2007.00084.xDOI Listing
March 2008

Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use.

Biol Psychiatry 2008 Jan 27;63(2):146-51. Epub 2007 Jun 27.

Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S000632230700375
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http://dx.doi.org/10.1016/j.biopsych.2007.04.026DOI Listing
January 2008

Salvia (Lamiaceae) is not monophyletic: implications for the systematics, radiation, and ecological specializations of Salvia and tribe Mentheae.

Am J Bot 2004 Jul;91(7):1115-25

Department of Botany, University of Wisconsin, Madison, Wisconsin 53706 USA;

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http://dx.doi.org/10.3732/ajb.91.7.1115DOI Listing
July 2004

Molecular phylogeny of cycads inferred from rbcL sequences.

Naturwissenschaften 2002 May;89(5):221-5

Institut für Pharmazeutische Biologie, Universität Heidelberg, Germany.

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May 2002