Jens T Siveke

Jens T Siveke

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Jens T Siveke

Publications by authors named "Jens T Siveke"

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Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity.

Angew Chem Int Ed Engl 2019 Oct 4. Epub 2019 Oct 4.

Technische Universität Dortmund, Chemistry and Chemical Biology, Otto-Hahn-Strasse 6, 44227, Dortmund, GERMANY.

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http://dx.doi.org/10.1002/anie.201909857DOI Listing
October 2019

Immunotherapy and Combination Strategies in Pancreatic Cancer: Current Status and Emerging Trends.

Oncol Res Treat 2018 26;41(5):286-290. Epub 2018 Apr 26.

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http://dx.doi.org/10.1159/000488917DOI Listing
August 2019

NAPOLI-1 phase 3 study of liposomal irinotecan in metastatic pancreatic cancer: Final overall survival analysis and characteristics of long-term survivors.

Eur J Cancer 2019 Feb 14;108:78-87. Epub 2019 Jan 14.

National Health Research Institutes - National Institute of Cancer Research, No. 367, Sheng-Li Road, Tainan, 70456, Taiwan.

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http://dx.doi.org/10.1016/j.ejca.2018.12.007DOI Listing
February 2019

Quality of life in metastatic pancreatic cancer patients receiving liposomal irinotecan plus 5-fluorouracil and leucovorin.

Eur J Cancer 2019 Jan 17;106:24-33. Epub 2018 Nov 17.

Division of Solid Tumor Translational Oncology, West German Cancer Center, University Hospital Essen, Hufelandstrasse 55, 45147, Essen, Germany; German Cancer Consortium (DKTK, Partner Site Essen) and German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ejca.2018.09.029DOI Listing
January 2019

Still a hopeless case for personalized oncology? Pancreatic cancer revisited.

Oncoscience 2019 Jan 22;6(1-2):285-286. Epub 2018 Aug 22.

Member of the German Cancer Consortium (DKTK), Institute of Pathology, Technical University Munich, 81675 Munich, Germany.

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http://dx.doi.org/10.18632/oncoscience.464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382256PMC
January 2019

Fibroblast-Activating Protein: Targeting the Roots of the Tumor Microenvironment.

Authors:
Jens T Siveke

J Nucl Med 2018 09 10;59(9):1412-1414. Epub 2018 Aug 10.

Division of Solid Tumor Translational Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany; and German Cancer Consortium and German Cancer Research Center, Heidelberg, Germany

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http://dx.doi.org/10.2967/jnumed.118.214361DOI Listing
September 2018

PAXgene fixation enables comprehensive metabolomic and proteomic analyses of tissue specimens by MALDI MSI.

Biochim Biophys Acta Gen Subj 2018 Jan 9;1862(1):51-60. Epub 2017 Oct 9.

Research Unit Analytical Pathology, Helmholtz Zentrum München, Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2017.10.005DOI Listing
January 2018

Multiparametric 18F-FDG PET/MR follow-up in a patient with autoimmune pancreatitis.

Eur J Hybrid Imaging 2017 22;1(1):11. Epub 2017 Nov 22.

Technical University of Munich Klinikum rechts der Isar, Department of Nuclear Medicine, Munich, Germany.

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http://dx.doi.org/10.1186/s41824-017-0016-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954669PMC
November 2017

Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner.

Nucleic Acids Res 2017 Jun;45(11):6334-6349

Department of General, Visceral and Pediatric Surgery, Göttingen Center for Molecular Biosciences, University Medical Center Göttingen, Justus-von-Liebig-Weg 11, 37077 Göttingen, Germany.

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http://dx.doi.org/10.1093/nar/gkx212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499659PMC
June 2017

Extended RAS analysis and correlation with overall survival in advanced pancreatic cancer.

Br J Cancer 2017 May 27;116(11):1462-1469. Epub 2017 Apr 27.

Department of Internal Medicine III and Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Marchioninistr. 15, Munich 81377, Germany.

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http://dx.doi.org/10.1038/bjc.2017.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520094PMC
May 2017

Oncogenic KRas-induced Increase in Fluid-phase Endocytosis is Dependent on N-WASP and is Required for the Formation of Pancreatic Preneoplastic Lesions.

EBioMedicine 2017 Feb 24;15:90-99. Epub 2016 Dec 24.

Clinic and Polyclinic for Internal Medicine II, Klinikum Rechts der Isar, Technical University of Munich, Germany; German Cancer Consortium (DKTK) and German Cancer Research Center, DKFZ, Heidelberg, Germany; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK), Partner Site Essen, West German Cancer Center, University Hospital Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233824PMC
February 2017

Epigenetic treatment of pancreatic cancer: is there a therapeutic perspective on the horizon?

Gut 2017 01 3;66(1):168-179. Epub 2016 Nov 3.

Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center Goettingen, Goettingen, Germany.

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http://dx.doi.org/10.1136/gutjnl-2016-312539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256386PMC
January 2017

Hes1 Controls Exocrine Cell Plasticity and Restricts Development of Pancreatic Ductal Adenocarcinoma in a Mouse Model.

Am J Pathol 2016 11 14;186(11):2934-2944. Epub 2016 Sep 14.

II Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany; German Cancer Consortium and German Cancer Research Center, Heidelberg, Germany; Division of Solid Tumor Translational Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2016.07.025DOI Listing
November 2016

Modeling Therapy Response and Spatial Tissue Distribution of Erlotinib in Pancreatic Cancer.

Mol Cancer Ther 2016 05 28;15(5):1145-52. Epub 2016 Jan 28.

2. Medizinische Klinik, Technische Universität München, Munich, Germany. German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany. Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK) Partner Site Essen, West German Cancer Center, University Hospital Essen, Essen, Germany.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0165DOI Listing
May 2016

Next-generation metabolic imaging in pancreatic cancer.

Gut 2016 Mar 13;65(3):367-9. Epub 2015 Oct 13.

Division of Translational Solid Tumor Oncology, German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany and German Cancer Research Center (DKFZ), Heidelberg, Germany Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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http://gut.bmj.com/content/65/3/367.full.pdf
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http://dx.doi.org/10.1136/gutjnl-2015-310518DOI Listing
March 2016

Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial.

Lancet 2016 Feb 29;387(10018):545-557. Epub 2015 Nov 29.

National Institute of Cancer Research, National Health Research Institutes, Tainan, and Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan. Electronic address:

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http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(
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http://linkinghub.elsevier.com/retrieve/pii/S014067361500986
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http://dx.doi.org/10.1016/S0140-6736(15)00986-1DOI Listing
February 2016

Current methods in mouse models of pancreatic cancer.

Methods Mol Biol 2015 ;1267:185-215

Departments of Genetics and Pediatrics, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1007/978-1-4939-2297-0_9DOI Listing
September 2015

Thrombophilic factor analysis in cirrhotic patients with portal vein thrombosis.

J Thromb Thrombolysis 2015 Jul;40(1):54-60

II. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, Munich, Germany,

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http://dx.doi.org/10.1007/s11239-014-1124-zDOI Listing
July 2015

Selective in vivo imaging of syngeneic, spontaneous, and xenograft tumors using a novel tumor cell-specific hsp70 peptide-based probe.

Cancer Res 2014 Dec 9;74(23):6903-12. Epub 2014 Oct 9.

Department of Radiation Oncology, Klinikum rechts der Isar, TU München and CCG - "Innate Immunity in Tumor Biology", Helmholtz Zentrum München (HMGU), Munich, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0413DOI Listing
December 2014

The increasing diversity of KRAS signaling in pancreatic cancer.

Authors:
Jens T Siveke

Gastroenterology 2014 Oct 11;147(4):736-9. Epub 2014 Sep 11.

II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.08.026DOI Listing
October 2014

Translational research in pancreatic ductal adenocarcinoma: current evidence and future concepts.

World J Gastroenterol 2014 Aug;20(31):10769-77

Stephan Kruger, Michael Haas, Sibylle Bächmann, Volker Heinemann, Stefan Boeck, Department of Internal Medicine III and Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, D-81377 Munich, Germany.

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http://dx.doi.org/10.3748/wjg.v20.i31.10769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138457PMC
August 2014

Critical appraisal of locoregional failure and systemic disease progression after preoperative chemoradiation of esophageal adenocarcinoma.

J Clin Oncol 2014 Jul 27;32(19):2112. Epub 2014 May 27.

Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1200/JCO.2013.54.7398DOI Listing
July 2014

Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D.

Cancer Discov 2014 Jun 2;4(6):688-701. Epub 2014 Apr 2.

Authors' Affiliations:Signaling and Transcription Laboratory, Department of Gastroenterology, Philipps University, Marburg; Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center Göttingen, Göttingen; II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität; Institute of Pathology, Helmholtz Zentrum, Munich; Theodor Boveri Institute, University of Würzburg, Würzburg; Institute for Genetics, Justus-Liebig-University, Giessen, Germany; Schulze Center for Novel Therapeutics, Division of Oncology Research; Divisions of Anatomic Pathology and Biostatistics, College of Medicine; Laboratory of Epigenetics and Chromatin Dynamics, Department of Medicine, Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota; Barrow Brain Tumor Research Center, St. Joseph's Hospital and Medical Center, Phoenix, Arizona; and Cold Spring Harbor Laboratory, Cold Spring Harbor, New York

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http://dx.doi.org/10.1158/2159-8290.CD-13-0593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069603PMC
June 2014

Validation of heat shock protein 70 as a tumor-specific biomarker for monitoring the outcome of radiation therapy in tumor mouse models.

Int J Radiat Oncol Biol Phys 2014 Mar;88(3):694-700

Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Clinical Kooperation Group, Innate Immunity in Tumor Biology, HelmholtzZentrum München, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2013.11.008DOI Listing
March 2014

Approach to cystic lesions of the pancreas.

Wien Med Wochenschr 2014 Feb 20;164(3-4):44-50. Epub 2013 Nov 20.

II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Ismaningerstr. 22, 81675, München, Deutschland,

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http://dx.doi.org/10.1007/s10354-013-0244-yDOI Listing
February 2014

Translational research in pancreatic cancer: KRAS and beyond.

Pancreas 2014 Jan;43(1):150-2

Department of Internal Medicine III and Comprehensive Cancer Center Klinikum Grosshadern Ludwig-Maximilians-University of Munich, Germany Department of Pathology Ludwig-Maximilians-University of Munich, Germany Department of Internal Medicine III and Comprehensive Cancer Center Klinikum Grosshadern Ludwig-Maximilians-University of Munich, Germany Department of Internal Medicine III and Comprehensive Cancer Center Klinikum Grosshadern Ludwig-Maximilians-University of Munich, Germany and Department of Pathology Ludwig-Maximilians-University of Munich, Germany Institute of Medical Informatics Biometry and Epidemiology Ludwig-Maximilians-University of Munich, Germany Department of Internal Medicine II Klinikum Rechts der Isar Technical University of Munich, Germany Department of Pathology Ludwig-Maximilians-University of Munich, Germany Department of Internal Medicine III and Comprehensive Cancer Center Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Germany.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MPA.0b013e31829629f6DOI Listing
January 2014

Reply: To PMID 23315998.

Hepatology 2013 Nov 12;58(5):1859-60. Epub 2013 Sep 12.

2nd Department of Internal Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

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http://dx.doi.org/10.1002/hep.26410DOI Listing
November 2013

Canonical Notch2 signaling determines biliary cell fates of embryonic hepatoblasts and adult hepatocytes independent of Hes1.

Hepatology 2013 Jun 17;57(6):2469-79. Epub 2013 Apr 17.

2nd Department of Internal Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

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http://dx.doi.org/10.1002/hep.26254DOI Listing
June 2013

The role of insulin and IGF system in pancreatic cancer.

J Mol Endocrinol 2013 Jun 23;50(3):R67-74. Epub 2013 Apr 23.

II Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Ismaningerstr 22, 81675 Munich, Germany.

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http://dx.doi.org/10.1530/JME-12-0259DOI Listing
June 2013

Genetically engineered mouse models of pancreatic cancer: unravelling tumour biology and progressing translational oncology.

Gut 2012 Oct 26;61(10):1488-500. Epub 2011 Aug 26.

II. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaningerstr. 22, München 81675, Germany.

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http://dx.doi.org/10.1136/gutjnl-2011-300756DOI Listing
October 2012

Direct molecular tissue analysis by MALDI imaging mass spectrometry in the field of gastrointestinal disease.

Gastroenterology 2012 Sep 20;143(3):544-549.e2. Epub 2012 Jul 20.

Institute of Pathology, Research Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2012.07.022DOI Listing
September 2012

Expression and clinicopathological significance of notch signaling and cell-fate genes in biliary tract cancer.

Am J Gastroenterol 2012 Jan 20;107(1):126-35. Epub 2011 Sep 20.

2nd Department of Internal Medicine, Klinikum rechts der Isar, Technische Universität München, Germany.

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http://www.nature.com/articles/ajg2011305
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http://dx.doi.org/10.1038/ajg.2011.305DOI Listing
January 2012

Early requirement of Rac1 in a mouse model of pancreatic cancer.

Gastroenterology 2011 Aug 28;141(2):719-30, 730.e1-7. Epub 2011 Apr 28.

II. Medizinische Klinik Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1053/j.gastro.2011.04.043DOI Listing
August 2011

Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma.

Proc Natl Acad Sci U S A 2010 Jul 12;107(30):13438-43. Epub 2010 Jul 12.

Second Department of Internal Medicine and Institute of Pathology, Technical University of Munich, 81675 Munich, Germany.

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http://dx.doi.org/10.1073/pnas.1002423107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922150PMC
July 2010

Betacellulin protects from pancreatitis by activating stress-activated protein kinase.

Gastroenterology 2010 Apr 29;138(4):1585-94, 1594.e1-3. Epub 2009 Dec 29.

Institute of Molecular Animal Breeding and Biotechnology, Gene Center of the LMU Munich, Germany.

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http://dx.doi.org/10.1053/j.gastro.2009.12.045DOI Listing
April 2010

Conditional inactivation of Myc impairs development of the exocrine pancreas.

Development 2008 Oct 20;135(19):3191-6. Epub 2008 Aug 20.

Department of Internal Medicine, Technical University of Munich, Munich, Germany.

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http://dx.doi.org/10.1242/dev.017137DOI Listing
October 2008

Conditional ablation of Notch signaling in pancreatic development.

Development 2008 Aug 17;135(16):2757-65. Epub 2008 Jul 17.

Department of Internal Medicine, Technical University of Munich, Ismaniger Strasse 22, 81675 Munich, Germany.

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http://dx.doi.org/10.1242/dev.013722DOI Listing
August 2008

Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice.

Hepatology 2008 Aug;48(2):607-16

Second Department of Internal Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

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http://dx.doi.org/10.1002/hep.22381DOI Listing
August 2008

Notch signaling is required for exocrine regeneration after acute pancreatitis.

Gastroenterology 2008 Feb 4;134(2):544-55. Epub 2007 Nov 4.

Second Department of Internal Medicine, Klinikum rechts der Isar, Technical University of Munich, München, Germany.

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http://dx.doi.org/10.1053/j.gastro.2007.11.003DOI Listing
February 2008

IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression.

EMBO J 2006 Aug 10;25(16):3801-12. Epub 2006 Aug 10.

Department of Internal Medicine II, Technical University of Munich, Munich, Germany.

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http://dx.doi.org/10.1038/sj.emboj.7601259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1553200PMC
August 2006

Pancreatic cancer: basic and clinical aspects.

Gastroenterology 2005 May;128(6):1606-25

II. Department of Internal Medicine, Technical University of Munich, Germany.

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http://dx.doi.org/10.1053/j.gastro.2005.04.001DOI Listing
May 2005

Chromosomal instability in mouse metastatic pancreatic cancer--it's Kras and Tp53 after all.

Cancer Cell 2005 May;7(5):405-7

2nd Department of Internal Medicine, Technical University of Munich, Klinikum rechts der Isar, Ismaningerstrasse 22, 81675 Munich, Germany.

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http://dx.doi.org/10.1016/j.ccr.2005.04.025DOI Listing
May 2005

Evidence for systemic manifestations in cerebroretinal vasculopathy.

Am J Med Genet A 2003 Dec;123A(3):309

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http://dx.doi.org/10.1002/ajmg.a.20369DOI Listing
December 2003

Stenosis of the common bile duct caused by synchronous pancreatic cystadenoma and cholangiocarcinoma.

Gastrointest Endosc 2003 Aug;58(2):311-2

Medizinische Poliklinik, Institut für Klinische Radiologie, Standort Innenstadt, Klinikum der Universität, Ludwig-Maximilians Universität, München.

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http://dx.doi.org/10.1067/mge.2003.351DOI Listing
August 2003