Jens Schittenhelm

Jens Schittenhelm

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Jens Schittenhelm

Jens Schittenhelm

Publications by authors named "Jens Schittenhelm"

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Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes.

Authors:
Matthew Clarke Alan Mackay Britta Ismer Jessica Chiara Pickles Ruth G Tatevossian Scott Newman Tejus A Bale Iris Stoler Elisa Izquierdo Sara Temelso Diana M Carvalho Valeria Molinari Anna Burford Louise Howell Alex Virasami Amy R Fairchild Aimee Avery Jane Chalker Mark Kristiansen Kelly Haupfear James D Dalton Wilda Orisme Ji Wen Michael Hubank Kathreena M Kurian Catherine Rowe Mellissa Maybury Stephen Crosier Jeffrey Knipstein Ulrich Schuller Uwe Kordes David E Kram Matija Snuderl Leslie Bridges Andrew J Martin Lawrence J Doey Safa Al-Sarraj Christopher Chandler Bassel Zebian Claire Cairns Rachael Natrajan Jessica Kr Boult Simon P Robinson Martin Sill Ira J Dunkel Stephen W Gilheeney Marc K Rosenblum Debbie Hughes Paula Z Proszek Tobey J MacDonald Matthias Preusser Christine Haberler Irene Slavc Roger Packer Ho-Keung Ng Shani Caspi Mara Popovic Barbara Faganel Kotnik Matthew D Wood Lissa Baird Monika Ashok Davare David A Solomon Thale Kristin Olsen Petter Brandal Michael Farrell Jane B Cryan Michael Capra Michael Karremann Jens Schittenhelm Martin U Schuhmann Martin Ebinger Winand N M Dinjens Kornelius Kerl Simone Hettmer Torsten Pietsch Felipe Andreiuolo Pablo Hernaiz Driever Andrey Korshunov Lotte Hiddingh Barbara C Worst Dominik Sturm Marc Zuckermann Olaf Witt Tabitha Bloom Claire Mitchell Evelina Miele Giovanna Stefania Colafati Francesca Diomedi-Camassei Simon Bailey Andrew S Moore Timothy Eg Hassall Stephen Paul Lowis Maria Tsoli Mark J Cowley David S Ziegler Matthias A Karajannis Kristian Aquilina Darren R Hargrave Fernando Carceller Lynley V Marshall Andreas von Deimling Christof M Kramm Stefan M Pfister Felix Sahm Suzanne J Baker Angela Mastronuzzi Andrea Carai Maria Vinci David Capper Sergey Popov David W Ellison Thomas S Jacques David T W Jones Chris Jones

Cancer Discov 2020 Apr 1. Epub 2020 Apr 1.

Division of Cancer Therapeutics and Department of Molecular Pathology, Institute of Cancer Research

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http://dx.doi.org/10.1158/2159-8290.CD-19-1030DOI Listing
April 2020

High density DNA methylation array is a reliable alternative for PCR-based analysis of the MGMT promoter methylation status in glioblastoma.

Pathol Res Pract 2020 Jan 11;216(1):152728. Epub 2019 Nov 11.

Institute of Neurology (Edinger Institute), Goethe University, Frankfurt, Germany; NORLUX Neuro-Oncology Laboratory, Luxembourg Institute of Health (LIH), Luxembourg; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Luxembourg; National Center of Pathology (NCP), Laboratoire national de santé (LNS), Dudelange, Luxembourg; Luxembourg Centre of Neuropathology (LCNP), Luxembourg. Electronic address:

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http://dx.doi.org/10.1016/j.prp.2019.152728DOI Listing
January 2020

Corticosteroid-responsive aseptic meningitis during regorafenib treatment.

Neurooncol Pract 2019 Dec 18;6(6):508-509. Epub 2019 Jul 18.

Interdisciplinary Division of Neuro-Oncology, Departments of Neurology and Neurosurgery, Hertie Institute for Clinical Brain Research, University Hospital Tübingen, Eberhard Karls University Tübingen, Germany.

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http://dx.doi.org/10.1093/nop/npz030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105064PMC
December 2019

T1ρ-based dynamic glucose-enhanced (DGEρ) MRI at 3 T: method development and early clinical experience in the human brain.

Magn Reson Med 2019 11 23;82(5):1832-1847. Epub 2019 Jun 23.

Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.

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http://dx.doi.org/10.1002/mrm.27857DOI Listing
November 2019

Integrative assessment of brain and bone invasion in meningioma patients.

Radiat Oncol 2019 Jul 29;14(1):132. Epub 2019 Jul 29.

Department of Radiation Oncology, University Hospital Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany.

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http://dx.doi.org/10.1186/s13014-019-1341-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664715PMC
July 2019

Oncogenic BRAF Alterations and Their Role in Brain Tumors.

Cancers (Basel) 2019 Jun 8;11(6). Epub 2019 Jun 8.

Department of Neuropathology, Comprehensive Cancer Center Tübingen-Stuttgart and Eberhard Karls University Tübingen, Abt. für Neuropathologie, Calwer Str.3, 72074 Tübingen, Germany.

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http://dx.doi.org/10.3390/cancers11060794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627484PMC
June 2019

Oncogenic KRAS hotspot mutations are rare in IDH-mutant gliomas.

Brain Pathol 2019 05 1;29(3):321-324. Epub 2019 Feb 1.

Center for CNS Tumors, Comprehensive Cancer Center Tuebingen-Stuttgart, University Hospital of Tuebingen, Eberhard Karls University of Tuebingen, Tuebingen, Germany.

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http://doi.wiley.com/10.1111/bpa.12709
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http://dx.doi.org/10.1111/bpa.12709DOI Listing
May 2019

Combined use of MR-PET and 5-ALA for neurosurgical management of recurrent multiple malignant hemangiopericytomas.

J Neurosurg Sci 2019 Apr 6;63(2):240-242. Epub 2018 Mar 6.

Department of Neurosurgery, University Hospital Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.23736/S0390-5616.17.04064-4DOI Listing
April 2019

High frequency of H3 K27M mutations in adult midline gliomas.

J Cancer Res Clin Oncol 2019 Apr 4;145(4):839-850. Epub 2019 Jan 4.

Department of Neuropathology, Institute of Pathology and Neuropathology, University Hospital of Tuebingen, Eberhard Karls University of Tuebingen, 72076, Tuebingen, Germany.

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http://link.springer.com/10.1007/s00432-018-02836-5
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http://dx.doi.org/10.1007/s00432-018-02836-5DOI Listing
April 2019

Transsphenoidal Removal of Recurrent Osteoid Osteoma of Clivus.

World Neurosurg 2018 Dec 26;120:506-508. Epub 2018 Sep 26.

Department of Neurosurgery, University of Tuebingen, Tuebingen, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183217
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http://dx.doi.org/10.1016/j.wneu.2018.09.133DOI Listing
December 2018

High Expression of Somatostatin Receptors 2A, 3, and 5 in Corticotroph Pituitary Adenoma.

Int J Endocrinol 2018 9;2018:1763735. Epub 2018 Dec 9.

Center for CNS Tumors, Comprehensive Cancer Center Tuebingen-Stuttgart, University Hospital Tuebingen, Eberhard-Karls-University Tuebingen, Germany.

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http://dx.doi.org/10.1155/2018/1763735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304820PMC
December 2018

Tissue microarrays - translational biomarker research in the fast lane.

Expert Rev Mol Diagn 2018 10 13;18(10):833-835. Epub 2018 Sep 13.

b Center for CNS Tumors, Comprehensive Cancer Center Tuebingen-Stuttgart , University Hospital Tuebingen, Eberhard-Karls-University Tuebingen , Tuebingen , Germany.

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http://dx.doi.org/10.1080/14737159.2018.1522252DOI Listing
October 2018

Glioma Grading and Determination of IDH Mutation Status and ATRX loss by DCE and ASL Perfusion.

Clin Neuroradiol 2018 Sep 9;28(3):421-428. Epub 2017 May 9.

Diagnostic and Interventional Neuroradiology, Department of Radiology, Eberhard Karls University, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany.

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http://dx.doi.org/10.1007/s00062-017-0590-zDOI Listing
September 2018

Contrast enhancement predicting survival in integrated molecular subtypes of diffuse glioma: an observational cohort study.

J Neurooncol 2018 Sep 17;139(2):373-381. Epub 2018 Apr 17.

Institute of Neuropathology, Department of Pathology and Neuropathology, University Hospital Tübingen, Eberhard Karls University, Tübingen, Germany.

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http://dx.doi.org/10.1007/s11060-018-2872-yDOI Listing
September 2018

Glioma grading by dynamic susceptibility contrast perfusion and C-methionine positron emission tomography using different regions of interest.

Neuroradiology 2018 Apr 20;60(4):381-389. Epub 2018 Feb 20.

Diagnostic and Interventional Neuroradiology, Department of Radiology, Eberhard Karls University, Hoppe-Seyler-Straße 3, 72076, Tuebingen, Germany.

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http://dx.doi.org/10.1007/s00234-018-1993-5DOI Listing
April 2018

DNA methylation-based classification of central nervous system tumours.

Authors:
David Capper David T W Jones Martin Sill Volker Hovestadt Daniel Schrimpf Dominik Sturm Christian Koelsche Felix Sahm Lukas Chavez David E Reuss Annekathrin Kratz Annika K Wefers Kristin Huang Kristian W Pajtler Leonille Schweizer Damian Stichel Adriana Olar Nils W Engel Kerstin Lindenberg Patrick N Harter Anne K Braczynski Karl H Plate Hildegard Dohmen Boyan K Garvalov Roland Coras Annett Hölsken Ekkehard Hewer Melanie Bewerunge-Hudler Matthias Schick Roger Fischer Rudi Beschorner Jens Schittenhelm Ori Staszewski Khalida Wani Pascale Varlet Melanie Pages Petra Temming Dietmar Lohmann Florian Selt Hendrik Witt Till Milde Olaf Witt Eleonora Aronica Felice Giangaspero Elisabeth Rushing Wolfram Scheurlen Christoph Geisenberger Fausto J Rodriguez Albert Becker Matthias Preusser Christine Haberler Rolf Bjerkvig Jane Cryan Michael Farrell Martina Deckert Jürgen Hench Stephan Frank Jonathan Serrano Kasthuri Kannan Aristotelis Tsirigos Wolfgang Brück Silvia Hofer Stefanie Brehmer Marcel Seiz-Rosenhagen Daniel Hänggi Volkmar Hans Stephanie Rozsnoki Jordan R Hansford Patricia Kohlhof Bjarne W Kristensen Matt Lechner Beatriz Lopes Christian Mawrin Ralf Ketter Andreas Kulozik Ziad Khatib Frank Heppner Arend Koch Anne Jouvet Catherine Keohane Helmut Mühleisen Wolf Mueller Ute Pohl Marco Prinz Axel Benner Marc Zapatka Nicholas G Gottardo Pablo Hernáiz Driever Christof M Kramm Hermann L Müller Stefan Rutkowski Katja von Hoff Michael C Frühwald Astrid Gnekow Gudrun Fleischhack Stephan Tippelt Gabriele Calaminus Camelia-Maria Monoranu Arie Perry Chris Jones Thomas S Jacques Bernhard Radlwimmer Marco Gessi Torsten Pietsch Johannes Schramm Gabriele Schackert Manfred Westphal Guido Reifenberger Pieter Wesseling Michael Weller Vincent Peter Collins Ingmar Blümcke Martin Bendszus Jürgen Debus Annie Huang Nada Jabado Paul A Northcott Werner Paulus Amar Gajjar Giles W Robinson Michael D Taylor Zane Jaunmuktane Marina Ryzhova Michael Platten Andreas Unterberg Wolfgang Wick Matthias A Karajannis Michel Mittelbronn Till Acker Christian Hartmann Kenneth Aldape Ulrich Schüller Rolf Buslei Peter Lichter Marcel Kool Christel Herold-Mende David W Ellison Martin Hasselblatt Matija Snuderl Sebastian Brandner Andrey Korshunov Andreas von Deimling Stefan M Pfister

Nature 2018 03 14;555(7697):469-474. Epub 2018 Mar 14.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature26000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093218PMC
March 2018

Immunohistochemical comparative analysis of GFAP, MAP - 2, NOGO - A, OLIG - 2 and WT - 1 expression in WHO 2016 classified neuroepithelial tumours and their prognostic value.

Pathol Res Pract 2018 Jan 14;214(1):15-24. Epub 2017 Dec 14.

Department of Neuropathology, Institute of Pathology and Neuropathology, University Hospital of Tuebingen, Eberhard Karls University of Tuebingen and Comprehensive Cancer Center Tuebingen-Stuttgart, Tuebingen, 72076, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03440338173086
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http://dx.doi.org/10.1016/j.prp.2017.12.009DOI Listing
January 2018

The Prognostic Impact of Ventricular Opening in Glioblastoma Surgery: A Retrospective Single Center Analysis.

World Neurosurg 2017 Oct 18;106:615-624. Epub 2017 Jul 18.

Department of Neurosurgery, University Hospital Tuebingen, Eberhard Karls University, Tuebingen, Germany; Center for CNS Tumors, Comprehensive Cancer Center Tuebingen Stuttgart, University Hospital Tuebingen, Eberhard Karls University, Tuebingen, Germany.

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http://dx.doi.org/10.1016/j.wneu.2017.07.034DOI Listing
October 2017

The Cellular Retinoic Acid Binding Protein 2 Promotes Survival of Malignant Peripheral Nerve Sheath Tumor Cells.

Am J Pathol 2017 Jul 11;187(7):1623-1632. Epub 2017 May 11.

Institute of Neuropathology, University Hospital Münster, Münster, Germany; Institute of Pathology, Brandenburg Medical School, Brandenburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.02.021DOI Listing
July 2017

Implications of Vestibular Schwannoma Consistency: Analysis of 140 Cases Regarding Radiologic and Clinical Features.

World Neurosurg 2017 Mar 24;99:159-163. Epub 2016 Nov 24.

Department of Neurosurgery, Eberhard Karls University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1016/j.wneu.2016.11.082DOI Listing
March 2017

In vivo molecular profiling of human glioma using diffusion kurtosis imaging.

J Neurooncol 2017 01 7;131(1):93-101. Epub 2016 Sep 7.

Department of Neuroradiology, Eberhard Karls University, Tübingen, Germany.

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http://dx.doi.org/10.1007/s11060-016-2272-0DOI Listing
January 2017

Risk Factors of Preoperative and Early Postoperative Seizures in Patients with Meningioma: A Retrospective Single-Center Cohort Study.

World Neurosurg 2017 Jan 21;97:538-546. Epub 2016 Oct 21.

Department of Neurosurgery, Eberhard Karls University of Tübingen, University Hospital Tübingen, Tübingen, Germany; Neuro-Oncology Center, Comprehensive Cancer Center Tübingen, Eberhard Karls University of Tübingen, University Hospital Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1016/j.wneu.2016.10.062DOI Listing
January 2017

Recent advances in subtyping tumors of the central nervous system using molecular data.

Expert Rev Mol Diagn 2017 01 9;17(1):83-94. Epub 2016 Dec 9.

a Department of Neuropathology, Institute of Pathology and Neuropathology, University Hospital of Tuebingen , Eberhard Karls University of Tuebingen , Tuebingen , Germany.

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https://www.tandfonline.com/doi/full/10.1080/14737159.2017.1
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http://dx.doi.org/10.1080/14737159.2017.1266259DOI Listing
January 2017

EBV-negative aggressive B-cell lymphomas of donor origin after allogeneic hematopoietic stem cell transplantation: a report of three cases.

Leuk Lymphoma 2016 11 6;57(11):2603-11. Epub 2016 Apr 6.

a Institute of Pathology and Neuropathology , University Hospital and Comprehensive Cancer Center Tuebingen, University of Tuebingen , Tuebingen , Germany ;

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http://dx.doi.org/10.3109/10428194.2016.1160088DOI Listing
November 2016

The role of integrins in primary and secondary brain tumors.

Histol Histopathol 2016 Oct 14;31(10):1069-78. Epub 2016 Apr 14.

Department of Pathology, University Medical Hospital, Eberhard Karls University Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.14670/HH-11-7741DOI Listing
October 2016

IDH1 R132H mutation in a pilocytic astrocytoma: a case report.

Int J Clin Exp Pathol 2015 1;8(9):11809-13. Epub 2015 Sep 1.

Department of Pathology and Neuropathology, Eberhard-Karls-University Tuebingen, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637747PMC
September 2016

Brain invasion in otherwise benign meningiomas does not predict tumor recurrence.

Acta Neuropathol 2016 09 27;132(3):479-81. Epub 2016 Jul 27.

Edinger Institute, Institute of Neurology, Goethe University Frankfurt, 60528, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1007/s00401-016-1598-1DOI Listing
September 2016

ATRX immunostaining predicts IDH and H3F3A status in gliomas.

Acta Neuropathol Commun 2016 06 16;4(1):60. Epub 2016 Jun 16.

Department of Neuropathology, Institute of Pathology and Neuropathology, University Hospital of Tuebingen, Eberhard Karls University of Tuebingen, Calwerstr. 3, D-72076, Tuebingen, Germany.

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http://dx.doi.org/10.1186/s40478-016-0331-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910252PMC
June 2016

TERT Promoter Mutations and Risk of Recurrence in Meningioma.

J Natl Cancer Inst 2016 May 13;108(5). Epub 2015 Dec 13.

Affiliations of authors:Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg , Heidelberg , Germany (FS, DS, CK, DR, JB, AK, DC, SS, AvD); Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg , Germany (FS, DS, CK, DR, AK, DC, AvD); Department of Pathology (AO), Department of Genomic Medicine (QW), Department of Radiation Oncology (QW, EPS), and Department of Bioinformatics and Computational Biology (QW), The University of Texas MD Anderson Cancer Center , Houston, TX ; Department of Radiation Oncology (SA, JD) and Department of Neurosurgery (MSc, TU, CHM), University Hospital Heidelberg , Heidelberg , Germany ; Department of Neuropathology, Charité Medical University , Berlin , Germany (AK); Department of Pathology, University Hospital Nürnberg , Nürnberg , Germany (AFO): Department of Neurosurgery, Medical Faculty of the Ruprecht-Karls-University of Heidelberg , Mannheim , Germany (SB); Department of Neuropathology, Institute of Pathology and Neuropathology, University Tübingen , Tübingen , Germany (JS); Department of Neuropathology, University of Bonn , Bonn , Germany (AB); Department of Neurosurgery (BB) and Institute of Neuropathology (WP), University Hospital Münster , Münster , Germany (BB); Department of Neurosurgery, University Hospital Bonn , Bonn , Germany (KG, MSi); Department of Neurosurgery, University Hospital Würzburg , Würzburg , Germany (AFK); Department of Neurosurgery, University Hospital Hamburg , Hamburg , Germany (KL); Department of Neuropathology, Otto von Guericke University Magdeburg , Magdeburg , Germany (CM); Institute of Pathology, Saarland University , Homburg, Saarland , Germany (YJK); Department of Neurosurgery, Saarland University , Homburg , Germany (RK); MacFeeters-Hamilton Brain Tumour Centre, Princess Margaret Cancer Center , Toronto, Ontario , Canada (KDA); Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg , Germany (TH).

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http://dx.doi.org/10.1093/jnci/djv377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849806PMC
May 2016

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.

Authors:
Dominik Sturm Brent A Orr Umut H Toprak Volker Hovestadt David T W Jones David Capper Martin Sill Ivo Buchhalter Paul A Northcott Irina Leis Marina Ryzhova Christian Koelsche Elke Pfaff Sariah J Allen Gnanaprakash Balasubramanian Barbara C Worst Kristian W Pajtler Sebastian Brabetz Pascal D Johann Felix Sahm Jüri Reimand Alan Mackay Diana M Carvalho Marc Remke Joanna J Phillips Arie Perry Cynthia Cowdrey Rachid Drissi Maryam Fouladi Felice Giangaspero Maria Łastowska Wiesława Grajkowska Wolfram Scheurlen Torsten Pietsch Christian Hagel Johannes Gojo Daniela Lötsch Walter Berger Irene Slavc Christine Haberler Anne Jouvet Stefan Holm Silvia Hofer Marco Prinz Catherine Keohane Iris Fried Christian Mawrin David Scheie Bret C Mobley Matthew J Schniederjan Mariarita Santi Anna M Buccoliero Sonika Dahiya Christof M Kramm André O von Bueren Katja von Hoff Stefan Rutkowski Christel Herold-Mende Michael C Frühwald Till Milde Martin Hasselblatt Pieter Wesseling Jochen Rößler Ulrich Schüller Martin Ebinger Jens Schittenhelm Stephan Frank Rainer Grobholz Istvan Vajtai Volkmar Hans Reinhard Schneppenheim Karel Zitterbart V Peter Collins Eleonora Aronica Pascale Varlet Stephanie Puget Christelle Dufour Jacques Grill Dominique Figarella-Branger Marietta Wolter Martin U Schuhmann Tarek Shalaby Michael Grotzer Timothy van Meter Camelia-Maria Monoranu Jörg Felsberg Guido Reifenberger Matija Snuderl Lynn Ann Forrester Jan Koster Rogier Versteeg Richard Volckmann Peter van Sluis Stephan Wolf Tom Mikkelsen Amar Gajjar Kenneth Aldape Andrew S Moore Michael D Taylor Chris Jones Nada Jabado Matthias A Karajannis Roland Eils Matthias Schlesner Peter Lichter Andreas von Deimling Stefan M Pfister David W Ellison Andrey Korshunov Marcel Kool

Cell 2016 Feb;164(5):1060-1072

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.

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http://www.cell.com/cell/pdf/S0092-8674(16)00055-6.pdf
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http://www.cell.com/cms/attachment/2048488015/2058390163/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S009286741600055
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http://dx.doi.org/10.1016/j.cell.2016.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139621PMC
February 2016

Analysis of IDH1-R132 mutation, BRAF V600 mutation and KIAA1549-BRAF fusion transcript status in central nervous system tumors supports pediatric tumor classification.

J Cancer Res Clin Oncol 2016 Jan 27;142(1):89-100. Epub 2015 Jun 27.

Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tübingen, Calwerstr. 3, 72076, Tübingen, Germany.

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http://link.springer.com/content/pdf/10.1007%2Fs00432-015-20
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http://link.springer.com/10.1007/s00432-015-2006-2
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http://dx.doi.org/10.1007/s00432-015-2006-2DOI Listing
January 2016

Tumour necrosis factor receptor superfamily member 9 (TNFRSF9) is up-regulated in reactive astrocytes in human gliomas.

Neuropathol Appl Neurobiol 2015 Feb;41(2):e56-67

Edinger Institute, Institute of Neurology, Goethe University Frankfurt, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1111/nan.12135DOI Listing
February 2015

[Endocrine abnormalities in a patient with borderline personality disorder--case 8/2014].

Dtsch Med Wochenschr 2014 Dec 4;139(50):2602. Epub 2014 Dec 4.

Medizinische Klinik IV, Universitätsklinikum Tübingen.

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http://dx.doi.org/10.1055/s-0034-1387424DOI Listing
December 2014

Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma.

Acta Neuropathol 2014 Oct 21;128(4):551-9. Epub 2014 Aug 21.

Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, INF 224, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-014-1326-7DOI Listing
October 2014

Comparing the expression of integrins αvβ3, αvβ5, αvβ6, αvβ8, fibronectin and fibrinogen in human brain metastases and their corresponding primary tumors.

Int J Clin Exp Pathol 2013 15;6(12):2719-32. Epub 2013 Nov 15.

Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tübingen Tübingen 72076, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843253PMC
August 2014

WT1 expression increases with malignancy and indicates unfavourable outcome in astrocytoma.

J Clin Pathol 2014 Jul 7;67(7):556-61. Epub 2014 Mar 7.

Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1136/jclinpath-2013-202114DOI Listing
July 2014

A novel mutation in LRSAM1 causes axonal Charcot-Marie-Tooth disease with dominant inheritance.

BMC Neurol 2014 Jun 3;14:118. Epub 2014 Jun 3.

Department of Neurology and Hertie Institute for Clinical Brain Research, Hoppe-Seyler-Str, 3, 72076 Tübingen, Germany.

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http://dx.doi.org/10.1186/1471-2377-14-118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060843PMC
June 2014

BRAF-mutated pleomorphic xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression.

Brain Pathol 2014 Apr 29;24(3):221-9. Epub 2014 Jan 29.

Department of Neuropathology, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany; German Cancer Consortium (DKTK), CCU Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1111/bpa.12111DOI Listing
April 2014

The embryonic stem cell factor UTF1 serves as a reliable diagnostic marker for germinomas.

Pathology 2014 Apr;46(3):225-9

1Department of Neuropathology, University of Marburg 2Department of Neuropathology, Edinger Institute (Institute of Neurology), Goethe University, Frankfurt/Main 3Department of Neuropathology, Ruprecht-Karls-University of Heidelberg 4Department of Pathology, Klinikum Stuttgart 5Department of Neuropathology, Institute of Pathology and Neuropathology, Eberhard-Karls-University of Tuebingen, Germany.

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http://dx.doi.org/10.1097/PAT.0000000000000071DOI Listing
April 2014

Osteonectin expression in surrounding stroma of craniopharyngiomas: association with recurrence rate and brain infiltration.

Int J Surg Pathol 2013 Dec 6;21(6):591-8. Epub 2013 May 6.

1Division of Immunopathology of the Nervous System.

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http://dx.doi.org/10.1177/1066896913486695DOI Listing
December 2013

Invasion patterns in brain metastases of solid cancers.

Neuro Oncol 2013 Dec 30;15(12):1664-72. Epub 2013 Sep 30.

Corresponding Author: Matthias Preusser, MD, Department of Medicine I and Comprehensive Cancer Center, Central Nervous System Tumours Unit (CCC-CNS), Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

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http://dx.doi.org/10.1093/neuonc/not112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829586PMC
December 2013

Prognostic relevance of global histone 3 lysine 9 acetylation in ependymal tumors.

J Neurosurg 2013 Dec 11;119(6):1424-31. Epub 2013 Oct 11.

Division of Immunopathology of the Nervous System;

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http://dx.doi.org/10.3171/2013.9.JNS13511DOI Listing
December 2013

Intravoxel incoherent motion diffusion-weighted MR imaging of gliomas: feasibility of the method and initial results.

Neuroradiology 2013 Oct 14;55(10):1189-96. Epub 2013 Jul 14.

Department of Diagnostic and Interventional Neuroradiology, Eberhard Karls University, Hoppe Seyler Str. 3, 72076, Tübingen, Germany,

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http://dx.doi.org/10.1007/s00234-013-1229-7DOI Listing
October 2013

Differential expression of the tumor suppressor A-kinase anchor protein 12 in human diffuse and pilocytic astrocytomas is regulated by promoter methylation.

J Neuropathol Exp Neurol 2013 Oct;72(10):933-41

From the Institute of Pathology, University Hospital Heidelberg (BG, MR, WW, PS); Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ) (CRS, LG, CD, PS, OP, CP); Department of Neuropathology, University of Heidelberg (DC); Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ) (DC, WW); and Department of Neuroradiology, University of Heidelberg (MNV), Heidelberg; Edinger Institute, University Hospital Frankfurt a.M., Frankfurt (CZ, JZ, PNH, MM); and Division of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg (BC); and Department of Neurooncology, Neurology Clinic and National Center for Tumor Diseases, University of Heidelberg (WW), Heidelberg, Germany; Department of Neurology, University Hospital Zurich, Zurich, Switzerland (MW); and Department of Neuropathology, Institute of Pathology and Neuropathology, Eberhard-Karls-University of Tübingen, Tübingen (RM, JS); and Department of Sports Medicine, Rehabilitation and Disease Prevention, Johannes Gutenberg University, Mainz (PS), Germany.

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http://dx.doi.org/10.1097/NEN.0b013e3182a59a88DOI Listing
October 2013

Management of holocord pilocytic astrocytomas in children and adolescents: an update.

Pediatr Neurosurg 2012 21;48(3):133-40. Epub 2013 Feb 21.

Department of Neurosurgery, Children's Hospital, Eberhard Karl University, Tübingen, Germany.

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http://dx.doi.org/10.1159/000345593DOI Listing
September 2013

Mutant BRAF V600E protein in ganglioglioma is predominantly expressed by neuronal tumor cells.

Acta Neuropathol 2013 Jun 24;125(6):891-900. Epub 2013 Feb 24.

Department of Neuropathology, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-013-1100-2DOI Listing
June 2013

Longitudinal expression analysis of αv integrins in human gliomas reveals upregulation of integrin αvβ3 as a negative prognostic factor.

J Neuropathol Exp Neurol 2013 Mar;72(3):194-210

Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1097/NEN.0b013e3182851019DOI Listing
March 2013

The "go or grow" potential of gliomas is linked to the neuropeptide processing enzyme carboxypeptidase E and mediated by metabolic stress.

Acta Neuropathol 2012 Jul 15;124(1):83-97. Epub 2012 Jan 15.

Laboratory of Molecular Neuro-Oncology, Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Otfried-Müller-Str. 27, 72076, Tübingen, Germany.

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http://dx.doi.org/10.1007/s00401-011-0940-xDOI Listing
July 2012

Diagnostic value of EAAT-1 and Kir7.1 for distinguishing endolymphatic sac tumors from choroid plexus tumors.

Am J Clin Pathol 2012 Jul;138(1):85-9

Dept of Neuropathology, Institute of Pathology and Neuropathology, University of Tübingen, Calwerstr 3, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1309/AJCPPRKNNL09JTLPDOI Listing
July 2012

Paediatric clear cell meningioma with multiple distant recurrences after presumed intra-operative cell spread.

Childs Nerv Syst 2012 Jun 5;28(6):925-31. Epub 2012 Jan 5.

Department of Neuropathology, Institute of Pathology and Neuropathology, University Hospital of Tübingen, Tübingen, Germany.

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http://link.springer.com/10.1007/s00381-011-1669-5
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http://dx.doi.org/10.1007/s00381-011-1669-5DOI Listing
June 2012

Atypical teratoid/rhabdoid tumors may show morphological and immunohistochemical features seen in choroid plexus tumors.

Neuropathology 2011 Oct 30;31(5):461-7. Epub 2011 Jan 30.

Institute for Brain Research Department of Neurosurgery, University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1111/j.1440-1789.2010.01189.xDOI Listing
October 2011

Parenchymal accumulation of CD163+ macrophages/microglia in multiple sclerosis brains.

J Neuroimmunol 2011 Aug 6;237(1-2):73-9. Epub 2011 Jul 6.

Institute of Immunology, Third Military Medical University of PLA, Gaotanyan Main Street 30, 400038, Chongqing, People's Republic of China.

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http://dx.doi.org/10.1016/j.jneuroim.2011.06.006DOI Listing
August 2011

WT1 expression in normal and neoplastic cranial and peripheral nerves is independent of grade of malignancy.

Cancer Biomark 2010 ;7(2):73-7

Institute of Brain Research, University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.3233/CBM-2010-0149DOI Listing
April 2011

Hypoxia-inducible factor-1α-dependent protection from intestinal ischemia/reperfusion injury involves ecto-5'-nucleotidase (CD73) and the A2B adenosine receptor.

J Immunol 2011 Apr 28;186(7):4367-74. Epub 2011 Feb 28.

Department of Anesthesiology and Critical Care Medicine, Tübingen University Hospital, D-72074 Tübingen, Germany.

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http://dx.doi.org/10.4049/jimmunol.0903617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884622PMC
April 2011