Jens Milbradt

Jens Milbradt

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Jens Milbradt

Jens Milbradt

Publications by authors named "Jens Milbradt"

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Human cytomegalovirus overcomes SAMHD1 restriction in macrophages via pUL97.

Nat Microbiol 2019 12 23;4(12):2260-2272. Epub 2019 Sep 23.

Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1038/s41564-019-0557-8DOI Listing
December 2019

A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SAMHD1.

Nat Microbiol 2019 12 23;4(12):2273-2284. Epub 2019 Sep 23.

Institute of Clinical and Molecular Virology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.

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http://dx.doi.org/10.1038/s41564-019-0529-zDOI Listing
December 2019

Human cytomegalovirus utilises cellular dual-specificity tyrosine phosphorylation-regulated kinases during placental replication.

Placenta 2018 12 13;72-73:10-19. Epub 2018 Oct 13.

Serology and Virology Division, SEALS Microbiology, Prince of Wales Hospital, Sydney, Australia; School of Women's and Children's Health, University of New South Wales, Australia; School of Medical Sciences, University of New South Wales, Australia; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.placenta.2018.10.002DOI Listing
December 2018

Transmembrane Protein pUL50 of Human Cytomegalovirus Inhibits ISGylation by Downregulating UBE1L.

J Virol 2018 08 17;92(15). Epub 2018 Jul 17.

Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Suwon, Republic of Korea

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http://dx.doi.org/10.1128/JVI.00462-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052311PMC
August 2018

Protein kinases responsible for the phosphorylation of the nuclear egress core complex of human cytomegalovirus.

J Gen Virol 2017 Oct 27;98(10):2569-2581. Epub 2017 Sep 27.

Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Erlangen, Germany.

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http://dx.doi.org/10.1099/jgv.0.000931DOI Listing
October 2017

Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity.

Antiviral Res 2017 07 9;143:113-121. Epub 2017 Apr 9.

Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Germany. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2017.04.003DOI Listing
July 2017

The human cytomegalovirus nuclear egress complex unites multiple functions: Recruitment of effectors, nuclear envelope rearrangement, and docking to nuclear capsids.

Rev Med Virol 2017 07 30;27(4). Epub 2017 Jun 30.

Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Erlangen, Germany.

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http://dx.doi.org/10.1002/rmv.1934DOI Listing
July 2017

Cytomegalovirus pUL50 is the multi-interacting determinant of the core nuclear egress complex (NEC) that recruits cellular accessory NEC components.

J Gen Virol 2016 07 4;97(7):1676-1685. Epub 2016 May 4.

Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Erlangen, Germany.

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http://dx.doi.org/10.1099/jgv.0.000495DOI Listing
July 2016

Human Cytomegalovirus Nuclear Egress Proteins Ectopically Expressed in the Heterologous Environment of Plant Cells are Strictly Targeted to the Nuclear Envelope.

Viruses 2016 Mar 10;8(3):73. Epub 2016 Mar 10.

Division of Biochemistry, Department of Biology, Friedrich-Alexander University Erlangen-Nuremberg, Staudtstrasse 5, Erlangen 91058, Germany.

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http://dx.doi.org/10.3390/v8030073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810263PMC
March 2016

Human cytomegalovirus replication is strictly inhibited by siRNAs targeting UL54, UL97 or UL122/123 gene transcripts.

PLoS One 2014 2;9(6):e97231. Epub 2014 Jun 2.

Virology Division, SEALS Microbiology, Prince of Wales Hospital, Sydney, Australia; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia; School of Medical Sciences, University of New South Wales, Sydney, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097231PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041654PMC
January 2015

The cytomegalovirus egress proteins pUL50 and pUL53 are translocated to the nuclear envelope through two distinct modes of nuclear import.

J Gen Virol 2013 Sep 5;94(Pt 9):2056-69. Epub 2013 Jun 5.

Institute for Clinical and Molecular Virology, University of Erlangen-Nuremberg, Erlangen, Germany.

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http://dx.doi.org/10.1099/vir.0.052571-0DOI Listing
September 2013

Nuclear import of isoforms of the cytomegalovirus kinase pUL97 is mediated by differential activity of NLS1 and NLS2 both acting through classical importin-α binding.

J Gen Virol 2012 Aug 2;93(Pt 8):1756-68. Epub 2012 May 2.

Institute for Clinical and Molecular Virology, University of Erlangen-Nuremberg, Schlossgarten 4, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1099/vir.0.040592-0DOI Listing
August 2012

Specific residues of a conserved domain in the N terminus of the human cytomegalovirus pUL50 protein determine its intranuclear interaction with pUL53.

J Biol Chem 2012 Jul 15;287(28):24004-16. Epub 2012 May 15.

Institute for Clinical and Molecular Virology, Division of Biotechnology, University of Erlangen-Nuremberg, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1074/jbc.M111.331207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390675PMC
July 2012

Regulatory roles of protein kinases in cytomegalovirus replication.

Adv Virus Res 2011 ;80:69-101

Institute for Clinical and Molecular Virology, University of Erlangen-Nuremberg, Erlangen, Germany.

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http://dx.doi.org/10.1016/B978-0-12-385987-7.00004-XDOI Listing
November 2011

The unique antiviral activity of artesunate is broadly effective against human cytomegaloviruses including therapy-resistant mutants.

Antiviral Res 2011 Nov 6;92(2):364-8. Epub 2011 Aug 6.

Division of Infectious Diseases, Oregon Health and Science University, Portland, Oregon, USA.

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http://dx.doi.org/10.1016/j.antiviral.2011.07.018DOI Listing
November 2011

Novel mode of phosphorylation-triggered reorganization of the nuclear lamina during nuclear egress of human cytomegalovirus.

J Biol Chem 2010 Apr 4;285(18):13979-89. Epub 2010 Mar 4.

Institute for Clinical and Molecular Virology, University of Erlangen-Nuremberg, D-91054 Erlangen, Germany.

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http://dx.doi.org/10.1074/jbc.M109.063628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859560PMC
April 2010

Sensitivity of human herpesvirus 6 and other human herpesviruses to the broad-spectrum antiinfective drug artesunate.

J Clin Virol 2009 Sep 4;46(1):24-8. Epub 2009 Jun 4.

Institute for Clinical and Molecular Virology, Medical Center Erlangen, University of Erlangen-Nuremberg, Germany.

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http://dx.doi.org/10.1016/j.jcv.2009.05.017DOI Listing
September 2009

Cytomegaloviral protein kinase pUL97 interacts with the nuclear mRNA export factor pUL69 to modulate its intranuclear localization and activity.

J Gen Virol 2009 Mar;90(Pt 3):567-78

Institute for Clinical and Molecular Virology, University of Erlangen-Nuremberg, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1099/vir.0.005827-0DOI Listing
March 2009

Cytomegaloviral proteins that associate with the nuclear lamina: components of a postulated nuclear egress complex.

J Gen Virol 2009 Mar;90(Pt 3):579-90

Institute for Clinical and Molecular Virology, University of Erlangen-Nuremberg, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1099/vir.0.005231-0DOI Listing
March 2009

Cytomegaloviral proteins pUL50 and pUL53 are associated with the nuclear lamina and interact with cellular protein kinase C.

J Gen Virol 2007 Oct;88(Pt 10):2642-50

Virological Institute of the University Hospital Erlangen, Clinical and Molecular Virology, University of Erlangen-Nuremberg, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1099/vir.0.82924-0DOI Listing
October 2007