Publications by authors named "Jens Kuhle"

100Publications

Serum Neurofilament Levels in Children With Febrile Seizures and in Controls.

Front Neurosci 2020 29;14:579958. Epub 2020 Sep 29.

Division of Neonatology and University of Basel Children's Hospital (UKBB), Basel, Switzerland.

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http://dx.doi.org/10.3389/fnins.2020.579958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550525PMC
September 2020

Serum neurofilament light chain as outcome marker for intensive care unit patients.

J Neurol 2020 Oct 23. Epub 2020 Oct 23.

Department of Neurology, Evangelisches Krankenhaus Hattingen, Hattingen, Germany.

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http://dx.doi.org/10.1007/s00415-020-10277-9DOI Listing
October 2020

Increasing cancer risk over calendar year in people with multiple sclerosis: a case-control study.

J Neurol 2020 Oct 21. Epub 2020 Oct 21.

Neurocenter of Southern Switzerland, Ospedale Regionale di Lugano Civico e Italiano, Via Tesserete 46, 6903, Lugano, Switzerland.

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http://dx.doi.org/10.1007/s00415-020-10170-5DOI Listing
October 2020

Serum Neurofilament Light Chain Is Associated with Incident Lacunes in Progressive Cerebral Small Vessel Disease.

J Stroke 2020 Sep 29;22(3):369-376. Epub 2020 Sep 29.

Donders Institute for Brain, Cognition and Behaviour, Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.5853/jos.2019.02845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568975PMC
September 2020

The weak association between neurofilament levels at multiple sclerosis onset and cognitive performance after 9 years.

Mult Scler Relat Disord 2020 Sep 28;46:102534. Epub 2020 Sep 28.

Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Katerinska 30, 120 00 Prague, Czech Republic. Electronic address:

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http://dx.doi.org/10.1016/j.msard.2020.102534DOI Listing
September 2020

Ratio and index of Neurofilament light chain indicate its origin in Guillain-Barré Syndrome.

Ann Clin Transl Neurol 2020 11 8;7(11):2213-2220. Epub 2020 Oct 8.

Institute of Molecular and Clinical Immunology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.

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http://dx.doi.org/10.1002/acn3.51207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664266PMC
November 2020

Evaluation of neurofilament light chain in the cerebrospinal fluid and blood as a biomarker for neuronal damage in experimental pneumococcal meningitis.

J Neuroinflammation 2020 Oct 7;17(1):293. Epub 2020 Oct 7.

Neuroinfection Laboratory, Institute for Infectious Diseases, University of Bern, Friedbühlstrasse 51, 3001, Bern, Switzerland.

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http://dx.doi.org/10.1186/s12974-020-01966-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539528PMC
October 2020

Serum neurofilament light chains in MS: Association with the Timed Up and Go.

Neurol Neuroimmunol Neuroinflamm 2020 Nov 25;7(6). Epub 2020 Sep 25.

From the Division of Neurology (G.A., G.B., P.H.L.), Department of Clinical Neurosciences, Geneva University Hospitals and Geneva University, Switzerland; Department of Neurology (G.A.), Albert Einstein College of Medicine, Yeshiva University, New York; Neurologic Clinic and Policlinic (J.K., D.L.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel and University of Basel; Willy Taillard Laboratory of Kinesiology (S.A.), Geneva University Hospitals and University of Geneva; Division of Laboratory Medicine (P.H.L.), Department of Genetic and Laboratory Medicine, Geneva University Hospitals; and Department of Pathology and Immunology (P.H.L.), Faculty of Medicine, University of Geneva, Switzerland.

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http://dx.doi.org/10.1212/NXI.0000000000000895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577527PMC
November 2020

Comparative analysis of dimethyl fumarate and fingolimod in relapsing-remitting multiple sclerosis.

J Neurol 2020 Sep 24. Epub 2020 Sep 24.

Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1007/s00415-020-10226-6DOI Listing
September 2020

Neurofilament light chain, a biomarker for polyneuropathy in systemic amyloidosis.

Amyloid 2020 Sep 4:1-6. Epub 2020 Sep 4.

Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1080/13506129.2020.1815696DOI Listing
September 2020

De-escalating rituximab dose results in stability of clinical, radiological, and serum neurofilament levels in multiple sclerosis.

Mult Scler 2020 Aug 25:1352458520952036. Epub 2020 Aug 25.

Multiple sclerosis Center, Department of Neurology, Neurocenter of Southern Switzerland (NSI), Ospedale Civico, Lugano, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.

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http://dx.doi.org/10.1177/1352458520952036DOI Listing
August 2020

Long-term prognostic value of longitudinal measurements of blood neurofilament levels.

Neurol Neuroimmunol Neuroinflamm 2020 09 12;7(5). Epub 2020 Aug 12.

From the Novartis Pharma AG (D.A.H., H.K., D.T.), Basel; Research Center for Clinical Neuroimmunology and Neuroscience Basel (L.K., D.L., J.K.), Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital and University of Basel, Switzerland; Department of Neurology (J.A.C.), Mellen MS Center, Neurological Institute, Cleveland Clinic, OH; Novartis Healthcare Pvt. Ltd. (A.S.), Hyderabad, India; and DATAMAP GmbH (R.M.), Freiburg, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428358PMC
September 2020

Lymphocyte recovery after fingolimod discontinuation in patients with MS.

Neurol Neuroimmunol Neuroinflamm 2020 Nov 14;7(6). Epub 2020 Aug 14.

From the Department of Neurology (S.N., J.K., T.D.), University Hospital Basel, University of Basel; Division of Developmental- and Neuropaediatrics (S.N.), University Children's Hospital of Basel (UKBB), University of Basel; and Department of Biomedicine (J.K., T.D.), University Hospital Basel, Switzerland.

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http://dx.doi.org/10.1212/NXI.0000000000000874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641093PMC
November 2020

Validation of Quantitative Scores Derived From Motor Evoked Potentials in the Assessment of Primary Progressive Multiple Sclerosis: A Longitudinal Study.

Front Neurol 2020 24;11:735. Epub 2020 Jul 24.

Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.3389/fneur.2020.00735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393441PMC
July 2020

Apolipoproteins AI and E are associated with neuroaxonal injury to gray matter in multiple sclerosis.

Mult Scler Relat Disord 2020 Oct 11;45:102389. Epub 2020 Jul 11.

Department of Pharmaceutical Sciences, State University of New York, Buffalo, NY, USA; Jacobs Comprehensive MS Treatment and Research Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.msard.2020.102389DOI Listing
October 2020

Serum neurofilament light as a biomarker in progressive multiple sclerosis.

Neurology 2020 09 16;95(10):436-444. Epub 2020 Jul 16.

From the University College London (R.K.), United Kingdom; National Multiple Sclerosis Society (K.E.S., M.A.), New York; McGill University (D.L.A.), Montreal, Canada; Perron Institute (W.C.), Sir Charles Gairdner Hospital, Perth, Australia; University Hospital Vall d'Hebron (M.C.), Barcelona, Spain; San Raffaele Scientific Institute (R.F.), Milan, Italy; Genentech/Roche (C.H.), South San Francisco; University Hospital Basel (J.K., D.L.), Switzerland; Biogen (T.P.), Boston; Quanterix Corporation (T.P.), Billerica; Rigshospitalet (F.S.), University of Copenhagen, Denmark; Progressive Multiple Sclerosis Alliance (C.S.), Glasgow, United Kingdom; Amsterdam UMC (C.E.T.), the Netherlands; MedDay Pharma (I.T.), Paris, France; Novartis (F.v.R.), Basel, Switzerland; Elizabeth Walker Consulting (E.W.), Seattle; and Mellen Center for Multiple Sclerosis (R.J.F.), Cleveland Clinic.

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http://dx.doi.org/10.1212/WNL.0000000000010346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538221PMC
September 2020

Association of neuronal injury blood marker neurofilament light chain with mild-to-moderate COVID-19.

J Neurol 2020 Dec 9;267(12):3476-3478. Epub 2020 Jul 9.

University Children's Hospital Regensburg (KUNO), Hospital St. Hedwig of the Order of St. John, University of Regensburg, Steinmetzstr. 1-3, 93049, Regensburg, Germany.

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http://dx.doi.org/10.1007/s00415-020-10050-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345451PMC
December 2020

Disability progression multiple sclerosis patients on fingolimod versus interferon-beta/glatiramer acetate.

Mult Scler 2020 May 28:1352458520918489. Epub 2020 May 28.

Neurologic Clinic and Policlinic, Departments of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1177/1352458520918489DOI Listing
May 2020

Plasma neurofilament light levels are associated with risk of disability in multiple sclerosis.

Neurology 2020 06 20;94(23):e2457-e2467. Epub 2020 May 20.

From the Department of Clinical Neuroscience (A.M., P.S., M.K., F.P., T.O., I.K.), The Karolinska Neuroimmunology & Multiple Sclerosis Centre, Karolinska Institutet; Centre for Molecular Medicine (A.M., P.S., M.K., F.P., T.O., I.K.), Karolinska University Hospital, Stockholm, Sweden; Departments of Medicine, Biomedicine, and Clinical Research (D.L., C.B., Z.M., L.K., J.K.), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel; Clinical Trial Unit (P.B.), Department of Clinical Research, University Hospital Basel, University of Switzerland; Institution of Neuroscience and Physiology (J.L.), Sahlgrenska Academy, University of Gothenburg, Gothenburg; Institute of Environmental Medicine (L.A.), Karolinska Institutet, Stockholm; and Centre for Occupational and Environmental Medicine (L.A.), Stockholm County Council, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000009571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455371PMC
June 2020

Serum neurofilament light chain and optical coherence tomography measures in MS: A longitudinal study.

Neurol Neuroimmunol Neuroinflamm 2020 07 18;7(4). Epub 2020 May 18.

From the Buffalo Neuroimaging Analysis Center (E.T., D.J., J.H., O.O., N.B., M.G.D., R.Z.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York; IRCCS (N.B.), Fondazione Don Carlo Gnocchi, Milan, Italy; Neurologic Clinic and Policlinic (J.K., C.B., Z.M., N.L.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Switzerland; Department of Pharmaceutical Sciences (M.R.), Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York; Novartis Pharma AG (D.T., H.K., D.L.), Basel, Switzerland; Jacobs MS Center (R.H.B.B., B.W.-G.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, and Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York.

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http://dx.doi.org/10.1212/NXI.0000000000000737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251512PMC
July 2020

Serum neurofilament light chain is a useful biomarker in pediatric multiple sclerosis.

Neurol Neuroimmunol Neuroinflamm 2020 07 13;7(4). Epub 2020 May 13.

From the Department of Pediatrics and Adolescent Medicine (M.-C.R., P.H., W.S., J.G.), Division of Pediatric Neurology, University Medical Centre Göttingen, Georg August University Göttingen, Germany; Clinical Trial Unit (P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Medical Image Analysis Centre Basel (MIAC AG) (J.W., E.R.); Department of Biomedical Engineering (J.W.), University Basel; Neurologic Clinic and Policlinic (Z.M., C.B., D.L., J.K.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel; Novartis Pharma AG (H.K., D.T.), Basel, Switzerland; and Institute of Neuropathology (W.B.), University Medical Centre Göttingen, Georg August University Göttingen, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238898PMC
July 2020

Vitamin D, smoking, EBV, and long-term cognitive performance in MS: 11-year follow-up of BENEFIT.

Neurology 2020 05 16;94(18):e1950-e1960. Epub 2020 Apr 16.

From the Department of Nutrition (M.C., K.L.M, A.A.), Harvard T.H. Chan School of Public Health, Boston, MA; Department of Global Public Health and Primary Care (M.C.), University of Bergen, Bergen, Norway; Department of Neurology (E.H.M.-L.), Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain; Departments of Medicine, Biomedicine and Clinical Research (C.B., L.K., J.K.), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Basel, Switzerland; CHU Hôpital Pontchaillou (G.E.), Rennes, France; University of Ottawa and Ottawa Hospital Research Institute (M.S.F.), Ottawa, Canada; Department of Neurology (H.-P.H.), Medical Faculty, Heinrich-Heine Universität, Düsseldorf, Germany; St. Michael's Hospital (X.M.), University of Toronto, Canada and Multiple Sclerosis Center of Catalonia (Cemcat) (X.M.), Vall d'Hebron University Hospital, Barcelona, Spain; Ferkauf Graduate School of Psychology (F.W.F.), Yeshiva University, New York, NY; Department of Neurology (I.K.P.), Medical Faculty, Heinrich-Heine Universität, Düsseldorf and COGITO Center for Applied Neurocognition and Neuropsychological Research (I.K.P.), Düsseldorf, Germany; Technical University of Munich (B.H.), School of Medicine and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Munich, Germany; Central Texas Neurology Consultants (E.J.F.), Round Rock, TX; Neuroimmunology and Multiple Sclerosis Research (S.S.), Department of Neurology, University Hospital Zurich, University of Zurich and Center for Neuroscience Zurich (S.S.), Federal Institute of Technology (ETH), Zurich, Switzerland; Bayer AG (E.-M.W.), Berlin, Germany; Department of Epidemiology (A.A.), Harvard T.H. Chan School of Public Health, Boston, MA and Channing Division of Network Medicine (A.A.); and Department of Medicine (A.A.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000009371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274920PMC
May 2020

Monitoring of radiologic disease activity by serum neurofilaments in MS.

Neurol Neuroimmunol Neuroinflamm 2020 07 9;7(4). Epub 2020 Apr 9.

From the Department of Medicine (T.U., T.K.), CORe, The University of Melbourne, Victoria, Australia; Department of Neurology and Center of Clinical Neuroscience (T.U., B.S., M.T., K.V., E.K.H., D.H.), Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Clinical Trial Unit (S.S., P.B.), Department of Clinical Research, University Hospital Basel, University of Basel; Departments of Medicine, Biomedicine and Clinical Research (C.B., J.O., D.L., Y.N., L.K., J. Kuhle), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel, Switzerland; Department of Neurology, Jacobs School of Medicine and Biomedical Sciences (N.B., M.D., R.Z.), Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo; IRCCS "S. Maria Nascente" (N.B.), Don Carlo Gnocchi Foundation, Milan, Italy; Department of Radiology (J. Krasensky, M.V.), Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, NY; and Department of Neurology (T.K.), The Royal Melbourne Hospital, Victoria, Australia.

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http://dx.doi.org/10.1212/NXI.0000000000000714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176248PMC
July 2020

Blood neurofilament light levels segregate treatment effects in multiple sclerosis.

Neurology 2020 03 11;94(11):e1201-e1212. Epub 2020 Feb 11.

From the Department of Medicine Solna, Clinical Epidemiology Division (B.D.), The Karolinska Neuroimmunology & Multiple Sclerosis Centre, Department of Clinical Neuroscience (A.M., I.K., T.O., F.P.), and Institute of Environmental Medicine (L.A.), Karolinska Institutet; Centre for Molecular Medicine (A.M., I.K., T.O., F.P.), Karolinska University Hospital, Stockholm, Sweden; Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine, and Clinical Research (C.B., Z.M., L.K., D.L., J.K.), and Clinical Trial Unit, Department of Clinical Research (P.B.), University Hospital Basel, University of Basel, Switzerland; Sanofi Genzyme (J.A.T.), Stockholm, Sweden; Biogen (T.P., B.C.K.), Cambridge, MA; Department of Neurology, Medical Faculty (B.C.K.), Heinrich-Heine University, Duesseldorf, Germany; and Institution of Neuroscience and Physiology (J.L.), Sahlgrenska Academy, University of Gothenburg, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000009097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387108PMC
March 2020

Serum neurofilament light levels in normal aging and their association with morphologic brain changes.

Nat Commun 2020 02 10;11(1):812. Epub 2020 Feb 10.

Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.

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http://dx.doi.org/10.1038/s41467-020-14612-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010701PMC
February 2020

Growth differentiation factor 15 is increased in stable MS.

Neurol Neuroimmunol Neuroinflamm 2020 03 5;7(2). Epub 2020 Feb 5.

From the Department of Biomedicine (A.A., M.C., C.F.), University of Basel; Neurologic Clinic and Policlinic (C.B., J.O., L.K., Y.N., J.K., M.M.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel; Medical Image Analysis Center Basel AG (M.A.); Division of Neuroradiology (M.A.), University Hospital Basel; Department of Biomedical Engineering (M.A.), University Basel, Switzerland; and Department of Gynaecology (J.W.), University Hospital Würzburg, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051204PMC
March 2020

Xenogeneic Neu5Gc and self-glycan Neu5Ac epitopes are potential immune targets in MS.

Neurol Neuroimmunol Neuroinflamm 2020 03 3;7(2). Epub 2020 Feb 3.

From the Institute of Pharmacology (K.F.B., S.v.G.), University of Bern, Switzerland; Neurologic Clinic and Policlinic (J.O., L.K., J.K.), Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital Basel, University of Basel, Switzerland; Department of Neurology with Institute of Translational Neurology (C.W.K., J.D.L.), University Hospital Münster, University of Münster, Germany; Laboratory of Neuroinflammation (C.W.K., B.P., J.D.L.), Institute of Experimental Immunology, University of Zurich, Switzerland; Department for BioMedical Research (DBMR) (R.R.), University of Bern, Switzerland; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Science (N.B.), Moscow, Russia; Auckland University of Technology (N.B.), New Zealand; and Department of Surgery (R.D.C.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1212/NXI.0000000000000676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051216PMC
March 2020

NfL and pNfH are increased in Friedreich's ataxia.

J Neurol 2020 May 30;267(5):1420-1430. Epub 2020 Jan 30.

Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany.

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http://dx.doi.org/10.1007/s00415-020-09722-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184046PMC
May 2020

Serum neurofilament light chain reflects inflammation-driven neurodegeneration and predicts delayed brain volume loss in early stage of multiple sclerosis.

Mult Scler 2020 Jan 21:1352458519901272. Epub 2020 Jan 21.

Department of Neurology and Center of Clinical Neuroscience, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic.

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http://dx.doi.org/10.1177/1352458519901272DOI Listing
January 2020

Plasma neurofilament light chain: an early biomarker for hereditary ATTR amyloid polyneuropathy.

Amyloid 2020 Jun 6;27(2):97-102. Epub 2020 Jan 6.

Molecular Neurobiology Group, Instituto de Biologia Molecular e Celular (IBMC) - Instituto de Investigação e Inovação em Saúde (i3S) da Universidade do Porto, Porto, Portugal.

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http://dx.doi.org/10.1080/13506129.2019.1708716DOI Listing
June 2020

PARP-1 deregulation in multiple sclerosis.

Mult Scler J Exp Transl Clin 2019 Oct-Dec;5(4):2055217319894604. Epub 2019 Dec 16.

Departments of Biomedicine and Neurology, University Hospital Basel, Switzerland.

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http://dx.doi.org/10.1177/2055217319894604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918498PMC
December 2019

Confounding effect of blood volume and body mass index on blood neurofilament light chain levels.

Ann Clin Transl Neurol 2020 01 1;7(1):139-143. Epub 2020 Jan 1.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/acn3.50972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952306PMC
January 2020

A multimodal approach to assess the validity of atrophied T2-lesion volume as an MRI marker of disease progression in multiple sclerosis.

J Neurol 2020 Mar 25;267(3):802-811. Epub 2019 Nov 25.

Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High Street, Buffalo, NY, 14203, USA.

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http://dx.doi.org/10.1007/s00415-019-09643-zDOI Listing
March 2020

Impact of parturition on maternal cardiovascular and neuronal integrity in a high risk cohort - a prospective cohort study.

BMC Pregnancy Childbirth 2019 Nov 5;19(1):403. Epub 2019 Nov 5.

Division of Neonatology, University Children's Hospital Basel (UKBB), Spitalstrasse 33, 4056, Basel, Switzerland.

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http://dx.doi.org/10.1186/s12884-019-2570-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833198PMC
November 2019

Vitamin D supplementation and neurofilament light chain in multiple sclerosis.

Acta Neurol Scand 2020 Jan 26;141(1):77-80. Epub 2019 Nov 26.

Department of Neurology, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1111/ane.13185DOI Listing
January 2020

Serum NfL levels should be used to monitor multiple sclerosis evolution - Yes.

Mult Scler 2020 01 18;26(1):17-19. Epub 2019 Oct 18.

Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1177/1352458519872921DOI Listing
January 2020

Serum neurofilament light chain level associations with clinical and cognitive performance in multiple sclerosis: A longitudinal retrospective 5-year study.

Mult Scler 2020 Nov 15;26(13):1670-1681. Epub 2019 Oct 15.

Jacobs MS Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.

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http://dx.doi.org/10.1177/1352458519881428DOI Listing
November 2020

A Framework for Estimating the Burden of Chronic Diseases: Design and Application in the Context of Multiple Sclerosis.

Front Neurol 2019 4;10:953. Epub 2019 Sep 4.

Department of Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.3389/fneur.2019.00953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742909PMC
September 2019

A case series on the value of tau and neurofilament protein levels to predict and detect delirium in cardiac surgery patients.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2019 Sep 16;163(3):241-246. Epub 2019 Sep 16.

Department of Anesthesiology and Intensive Care Medicine, University Medical Center Rostock, Rostock, Germany.

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http://dx.doi.org/10.5507/bp.2019.043DOI Listing
September 2019

Blood neurofilament light chain at the doorstep of clinical application.

Neurol Neuroimmunol Neuroinflamm 2019 09 8;6(5):e599. Epub 2019 Aug 8.

Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1212/NXI.0000000000000599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705620PMC
September 2019

Serum GFAP and neurofilament light as biomarkers of disease activity and disability in NMOSD.

Neurology 2019 09 30;93(13):e1299-e1311. Epub 2019 Aug 30.

From the Departments of Neurology (M.W., Y.N., T.M., F.H., R.Y., J.-i.K.) and Neurological Therapeutics (N.I.), Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; and Neurology (Z.M., C.B., D.L., J.K.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Switzerland.

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http://dx.doi.org/10.1212/WNL.0000000000008160DOI Listing
September 2019

Hepatitis E virus infections in patients with MS on oral disease-modifying treatment.

Neurol Neuroimmunol Neuroinflamm 2019 09 11;6(5). Epub 2019 Jul 11.

From the Departments of Medicine, University Hospital Basel, Neurologic Clinic and Policlinic, Clinical Research and Biomedicine, University of Basel, Petersgraben, Switzerland.

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http://dx.doi.org/10.1212/NXI.0000000000000594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705628PMC
September 2019

Serum neurofilament light chain levels associations with gray matter pathology: a 5-year longitudinal study.

Ann Clin Transl Neurol 2019 09 22;6(9):1757-1770. Epub 2019 Aug 22.

Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/acn3.50872
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http://dx.doi.org/10.1002/acn3.50872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764487PMC
September 2019

Serum neurofilament light chain in pediatric MS and other acquired demyelinating syndromes.

Neurology 2019 09 5;93(10):e968-e974. Epub 2019 Aug 5.

From the Department of Neurology, MS Centre ErasMS (Y.Y.M.W., A.L.B., D.v.P., R.Q.H.), Department of Immunology (M.-J.M., A.F.W., R.Q.H.), and Department of Pediatric Neurology (R.F.N.), Erasmus MC, Rotterdam, the Netherlands; and Neurologic Clinic and Policlinic (C.B., Z.M., J.K.), University Hospital Basel, Switzerland.

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http://dx.doi.org/10.1212/WNL.0000000000008057DOI Listing
September 2019

Serum neurofilament light chain as a prognostic marker in postanoxic encephalopathy.

Epilepsy Behav 2019 12 30;101(Pt B):106432. Epub 2019 Jul 30.

Neurocenter of Southern Switzerland, Civic Hospital, Lugano, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.yebeh.2019.07.033DOI Listing
December 2019

Plasma proteome in multiple sclerosis disease progression.

Ann Clin Transl Neurol 2019 09 31;6(9):1582-1594. Epub 2019 Jul 31.

Department of Clinical Chemistry, Amsterdam University Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/acn3.771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7651845PMC
September 2019

High-density lipoprotein cholesterol is associated with multiple sclerosis fatigue: A fatigue-metabolism nexus?

J Clin Lipidol 2019 Jul - Aug;13(4):654-663.e1. Epub 2019 Jun 18.

Department of Biotechnical and Clinical Laboratory Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA; Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.

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http://dx.doi.org/10.1016/j.jacl.2019.06.003DOI Listing
June 2020

Correlations between serum and CSF pNfH levels in ALS, FTD and controls: a comparison of three analytical approaches.

Clin Chem Lab Med 2019 Sep;57(10):1556-1564

Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1515/cclm-2019-0015DOI Listing
September 2019

Blood neurofilament light as a potential endpoint in Phase 2 studies in MS.

Ann Clin Transl Neurol 2019 Jun 28;6(6):1081-1089. Epub 2019 May 28.

Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering University Hospital Basel, University of Basel Basel Switzerland.

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http://dx.doi.org/10.1002/acn3.795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562031PMC
June 2019

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis.

JAMA Neurol 2019 Jun 17. Epub 2019 Jun 17.

UCL Institute of Neurology, Queen Square, London, United Kingdom.

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http://dx.doi.org/10.1001/jamaneurol.2019.1534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580449PMC
June 2019

Serum neurofilament light chain in chronic inflammatory demyelinating polyneuropathy.

J Peripher Nerv Syst 2019 06 29;24(2):187-194. Epub 2019 Apr 29.

Department of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/jns.12319DOI Listing
June 2019

Blood neurofilament light chain as a biomarker of MS disease activity and treatment response.

Neurology 2019 03 8;92(10):e1007-e1015. Epub 2019 Feb 8.

From the Neurologic Clinic and Policlinic (J.K., C.B., L.K.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel; Novartis Pharma AG (H.K., D.A.H., F.D., D.T., D.L.), Basel, Switzerland; Novartis Healthcare Pvt. Ltd. (U.K.), Hyderabad, India; and DATAMAP GmbH (R.M.), Freiburg, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000007032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442011PMC
March 2019

Central Slab versus Whole Brain to Measure Brain Atrophy in Multiple Sclerosis.

Eur Neurol 2018 3;80(3-4):207-214. Epub 2019 Jan 3.

Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland,

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https://www.karger.com/Article/FullText/495798
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http://dx.doi.org/10.1159/000495798DOI Listing
March 2019

Serum glial fibrillary acidic protein correlates with multiple sclerosis disease severity.

Mult Scler 2020 02 20;26(2):210-219. Epub 2018 Dec 20.

Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland/Division of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland.

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http://dx.doi.org/10.1177/1352458518819380DOI Listing
February 2020

Neurofilament Light Chain: Blood Biomarker of Neonatal Neuronal Injury.

Front Neurol 2018 20;9:984. Epub 2018 Nov 20.

Department of Neonatology, University Children's Hospital Basel, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.3389/fneur.2018.00984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256184PMC
November 2018

Patterns of care for Multiple Sclerosis in a setting of universal care access: A cross-sectional study.

Mult Scler Relat Disord 2019 Feb 2;28:17-25. Epub 2018 Dec 2.

Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 84, 8001 Zurich, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22110348183052
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http://dx.doi.org/10.1016/j.msard.2018.11.033DOI Listing
February 2019

NfL is a biomarker for adult-onset leukoencephalopathy with axonal spheroids and pigmented glia.

Neurology 2018 10 14;91(16):755-757. Epub 2018 Sep 14.

From the Department of Neurodegenerative Diseases (S.N.H., L.S.), Hertie-Institute for Clinical Brain Research & Center of Neurology, University of Tübingen, Germany; German Research Center for Neurodegenerative Diseases (DZNE) (S.N.H., L.S.), Tübingen, Germany; Institute of Human Genetics (I.K., F.R., J.R.L.), University of Leipzig, Germany; Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research (C.B., J.K.), University Hospital Basel, University of Basel, Switzerland; and Department of Neurology (P.K.), University of Magdeburg, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000006357DOI Listing
October 2018

Serum neurofilament light: A biomarker of neuroaxonal injury after ischemic stroke.

Neurology 2018 10 14;91(14):e1338-e1347. Epub 2018 Sep 14.

From the Institute for Stroke and Dementia Research, University Hospital (S.T., M. Duering, A.G.K., J.B., B.G., F.A.W., M. Dichgans), and Graduate School of Systemic Neurosciences (S.T.), LMU Munich; Munich Cluster for Systems Neurology (SyNergy) (S.T., M. Dichgans), Munich, Germany; Neurologic Clinic and Policlinic (C.B., J.K.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Switzerland; German Center for Neurodegenerative Diseases (DZNE) (F.J.B., G.C.P.), Bonn; Department of Neurology (F.J.B., G.C.P.), University Hospital Bonn; Departments of Neurology (M.K., L.K.), Neuroradiology (F.D.), and Radiology (B.E.-W.), University Hospital, LMU Munich; Department of Neurology (M.W.G.), University of Magdeburg, University Hospital; German Center for Neurodegenerative Diseases (DZNE) (M.W.G.), Magdeburg, Germany; Stroke Center and Department of Neurology (N.P.), University Hospital Basel, Switzerland; and German Center for Neurodegenerative Diseases (DZNE) (M. Dichgans), Munich, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000006282DOI Listing
October 2018

Neurofilaments as biomarkers in neurological disorders.

Nat Rev Neurol 2018 10;14(10):577-589

Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.

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http://www.nature.com/articles/s41582-018-0058-z
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http://dx.doi.org/10.1038/s41582-018-0058-zDOI Listing
October 2018

The disease burden of Multiple Sclerosis from the individual and population perspective: Which symptoms matter most?

Mult Scler Relat Disord 2018 Oct 21;25:112-121. Epub 2018 Jul 21.

Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.msard.2018.07.013DOI Listing
October 2018

Serum neurofilament light chain is increased in hereditary spastic paraplegias.

Ann Clin Transl Neurol 2018 Jul 21;5(7):876-882. Epub 2018 May 21.

Department of Neurodegenerative Diseases Hertie-Institute for Clinical Brain Research and Center of Neurology University of Tübingen Hoppe-Seyler-Str. 3 72076 Tübingen Germany.

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http://dx.doi.org/10.1002/acn3.583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043776PMC
July 2018

Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis.

Brain 2018 08;141(8):2382-2391

Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1093/brain/awy154DOI Listing
August 2018

Prodromal symptoms of multiple sclerosis in primary care.

Ann Neurol 2018 06 30;83(6):1162-1173. Epub 2018 May 30.

Neurocenter of Southern Switzerland, Civic Hospital, Lugano, Switzerland.

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http://dx.doi.org/10.1002/ana.25247DOI Listing
June 2018

Serum neurofilament light is increased in multiple system atrophy of cerebellar type and in repeat-expansion spinocerebellar ataxias: a pilot study.

J Neurol 2018 Jul 8;265(7):1618-1624. Epub 2018 May 8.

Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.

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http://dx.doi.org/10.1007/s00415-018-8893-9DOI Listing
July 2018

Comparative analysis of natalizumab versus fingolimod as second-line treatment in relapsing-remitting multiple sclerosis.

Mult Scler 2018 05 24;24(6):777-785. Epub 2018 Apr 24.

Neurologic Clinic and Policlinic, Department of Neurology, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1177/1352458518768433DOI Listing
May 2018

Serum neurofilament light chain is a biomarker of acute and chronic neuronal damage in early multiple sclerosis.

Mult Scler 2019 04 15;25(5):678-686. Epub 2018 Mar 15.

Department of Neurology and Focus Program Translational Neuroscience (FTN), Research Center for Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1177/1352458518765666DOI Listing
April 2019

Multicenter evaluation of neurofilaments in early symptom onset amyotrophic lateral sclerosis.

Neurology 2018 01 6;90(1):e22-e30. Epub 2017 Dec 6.

From the Nuffield Department of Clinical Neurosciences (E.F., E.G., M.R.T.), University of Oxford, UK; Department of Neurology (P.O., P.S., F.V., J.H.W., P.W., A.C.L., M.O.), Ulm University Hospital, Germany; Department of Pathophysiology and Transplantation (F.V., V.S.), Università degli Studi di Milano; Department of Neurology-Stroke Unit and Laboratory of Neuroscience (F.V., C.M., V.S.), IRCCS Istituto Auxologico Italiano, Milan, Italy; Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine (C.B., J.K.), University Hospital and University of Basel, Switzerland; Department of Neurology (P.V.D.) and Laboratory of Molecular Neurobiomarker Research and Laboratory Medicine (K.P.), University Hospitals Leuven; KU Leuven-University of Leuven (P.V.D.); Department of Neurosciences (P.V.D.), VIB-Center for Brain & Disease Research, Leuven, Belgium; Department of Neurology (J.G., P.M., B.S.), Jena University Hospital, Germany; Department of Metabolic Biochemistry (C.J., F.L.) and Neurological Diseases Department (M.d.M.A., F.S.), Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Paris, France; Department of Neurology (S.K., S.P.), Hannover Medical School; Institute for Epidemiology and Medical Biometry (B.M.) Ulm University, Germany; Donders Institute for Brain, Cognition and Behaviour, Department of Neurology (J.R., M.M.V.), and Radboud Alzheimer Center, Department of Laboratory Medicine (M.M.V.), Radboud University Medical Center, Nijmegen, the Netherlands; and Department of Neurodegenerative Disease and Gerontopsychiatry/Neurology (P.W.), Bonn University Hospital, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000004761DOI Listing
January 2018

Neurofilament light chain predicts disease activity in relapsing-remitting MS.

Neurol Neuroimmunol Neuroinflamm 2018 Jan 28;5(1):e422. Epub 2017 Nov 28.

Department of Neurology (K.N.V., K.B., K.-M.M., Ø.T., S.W., L.A.B., C.V.), Haukeland University Hospital; Department of Clinical Medicine (K.N.V., K.-M.M., Ø.T., S.W., L.A.B., C.V.), University of Bergen, Norway; Neurologic Clinic and Policlinic (C.B., J.K.), Departments of Medicine, Clinical Research and Biomedicine, University Hospital Basel, University of Basel, Switzerland; Department of Global Public Health and Primary Care (K.B.), University of Bergen, Norway; and Norwegian MS-Registry & Biobank (K.-M.M.).

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http://dx.doi.org/10.1212/NXI.0000000000000422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707445PMC
January 2018

Inflammatory and Neuronal Biomarkers Associated With Retinal Thinning in Pediatric HIV.

Invest Ophthalmol Vis Sci 2017 11;58(13):5985-5992

Department of Hematology, Immunology and Infectious Diseases, Emma Children's Hospital/Academic Medical Center, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1167/iovs.17-22252DOI Listing
November 2017

Serum neurofilament light is sensitive to active cerebral small vessel disease.

Neurology 2017 Nov 18;89(20):2108-2114. Epub 2017 Oct 18.

From the Department of Neurology (T.G., D.P., C.E., T.S.-H., M.K., S.F., A.P., M.V., L.P., E.H., S.R., R.S., F.F., M.K.), Division of Neuroradiology, Vascular and Interventional Radiology (C.E.), and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Austria; and Neurologic Clinic and Policlinic (C.B., S.G., J,K.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Switzerland.

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http://dx.doi.org/10.1212/WNL.0000000000004645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711505PMC
November 2017

Fluid biomarker and electrophysiological outcome measures for progressive MS trials.

Mult Scler 2017 Oct;23(12):1600-1613

Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital of Basel, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1177/1352458517732844DOI Listing
October 2017

Dimethyl fumarate influences innate and adaptive immunity in multiple sclerosis.

J Autoimmun 2018 01 27;86:39-50. Epub 2017 Sep 27.

Laboratory of Clinical Neuroimmunology, Neurologic Clinic and Policlinic, Departments of Biomedicine and Clinical Research, University Hospital Basel and University of Basel, Hebelstrasse 20, 4031, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2017.09.009DOI Listing
January 2018

Serum neurofilament light chain: a biomarker of neuronal injury in vasculitic neuropathy.

Ann Rheum Dis 2018 07 25;77(7):1093-1094. Epub 2017 Jul 25.

Clinic for Rheumatology, Department of Medicine, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1136/annrheumdis-2017-212045DOI Listing
July 2018

Exploring the effect of vitamin D supplementation on the anti-EBV antibody response in relapsing-remitting multiple sclerosis.

Mult Scler 2018 09 21;24(10):1280-1287. Epub 2017 Jul 21.

School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands/Academic MS Center Limburg, Zuyderland Medical Center, Sittard, The Netherlands.

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http://dx.doi.org/10.1177/1352458517722646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108041PMC
September 2018