Jens Kuhle

Jens Kuhle

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Jens Kuhle

Publications by authors named "Jens Kuhle"

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Impact of parturition on maternal cardiovascular and neuronal integrity in a high risk cohort - a prospective cohort study.

BMC Pregnancy Childbirth 2019 Nov 5;19(1):403. Epub 2019 Nov 5.

Division of Neonatology, University Children's Hospital Basel (UKBB), Spitalstrasse 33, 4056, Basel, Switzerland.

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http://dx.doi.org/10.1186/s12884-019-2570-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833198PMC
November 2019

A multimodal approach to assess the validity of atrophied T2-lesion volume as an MRI marker of disease progression in multiple sclerosis.

J Neurol 2019 Nov 25. Epub 2019 Nov 25.

Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High Street, Buffalo, NY, 14203, USA.

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http://dx.doi.org/10.1007/s00415-019-09643-zDOI Listing
November 2019

Serum neurofilament light chain level associations with clinical and cognitive performance in multiple sclerosis: A longitudinal retrospective 5-year study.

Mult Scler 2019 Oct 15:1352458519881428. Epub 2019 Oct 15.

Jacobs MS Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.

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http://dx.doi.org/10.1177/1352458519881428DOI Listing
October 2019

Serum NfL levels should be used to monitor multiple sclerosis evolution - Yes.

Mult Scler 2019 Oct 18:1352458519872921. Epub 2019 Oct 18.

Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1177/1352458519872921DOI Listing
October 2019

Vitamin D supplementation and neurofilament light chain in multiple sclerosis.

Acta Neurol Scand 2019 Oct 28. Epub 2019 Oct 28.

Department of Neurology, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1111/ane.13185DOI Listing
October 2019

Correlations between serum and CSF pNfH levels in ALS, FTD and controls: a comparison of three analytical approaches.

Clin Chem Lab Med 2019 Sep;57(10):1556-1564

Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1515/cclm-2019-0015DOI Listing
September 2019

Plasma proteome in multiple sclerosis disease progression.

Ann Clin Transl Neurol 2019 Sep 31;6(9):1582-1594. Epub 2019 Jul 31.

Department of Clinical Chemistry, Amsterdam University Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/acn3.771DOI Listing
September 2019

Serum neurofilament light chain in pediatric MS and other acquired demyelinating syndromes.

Neurology 2019 Sep 5;93(10):e968-e974. Epub 2019 Aug 5.

From the Department of Neurology, MS Centre ErasMS (Y.Y.M.W., A.L.B., D.v.P., R.Q.H.), Department of Immunology (M.-J.M., A.F.W., R.Q.H.), and Department of Pediatric Neurology (R.F.N.), Erasmus MC, Rotterdam, the Netherlands; and Neurologic Clinic and Policlinic (C.B., Z.M., J.K.), University Hospital Basel, Switzerland.

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http://dx.doi.org/10.1212/WNL.0000000000008057DOI Listing
September 2019

Serum neurofilament light chain levels associations with gray matter pathology: a 5-year longitudinal study.

Ann Clin Transl Neurol 2019 Sep 22;6(9):1757-1770. Epub 2019 Aug 22.

Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/acn3.50872
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http://dx.doi.org/10.1002/acn3.50872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764487PMC
September 2019

Hepatitis E virus infections in patients with MS on oral disease-modifying treatment.

Neurol Neuroimmunol Neuroinflamm 2019 Sep 11;6(5). Epub 2019 Jul 11.

From the Departments of Medicine, University Hospital Basel, Neurologic Clinic and Policlinic, Clinical Research and Biomedicine, University of Basel, Petersgraben, Switzerland.

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http://dx.doi.org/10.1212/NXI.0000000000000594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705628PMC
September 2019

Serum GFAP and neurofilament light as biomarkers of disease activity and disability in NMOSD.

Neurology 2019 Sep 30;93(13):e1299-e1311. Epub 2019 Aug 30.

From the Departments of Neurology (M.W., Y.N., T.M., F.H., R.Y., J.-i.K.) and Neurological Therapeutics (N.I.), Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; and Neurology (Z.M., C.B., D.L., J.K.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Switzerland.

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http://dx.doi.org/10.1212/WNL.0000000000008160DOI Listing
September 2019

Blood neurofilament light chain at the doorstep of clinical application.

Neurol Neuroimmunol Neuroinflamm 2019 Sep 8;6(5):e599. Epub 2019 Aug 8.

Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1212/NXI.0000000000000599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705620PMC
September 2019

A case series on the value of tau and neurofilament protein levels to predict and detect delirium in cardiac surgery patients.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2019 Sep 16;163(3):241-246. Epub 2019 Sep 16.

Department of Anesthesiology and Intensive Care Medicine, University Medical Center Rostock, Rostock, Germany.

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http://dx.doi.org/10.5507/bp.2019.043DOI Listing
September 2019

A Framework for Estimating the Burden of Chronic Diseases: Design and Application in the Context of Multiple Sclerosis.

Front Neurol 2019 4;10:953. Epub 2019 Sep 4.

Department of Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.3389/fneur.2019.00953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742909PMC
September 2019

Serum neurofilament light chain as a prognostic marker in postanoxic encephalopathy.

Epilepsy Behav 2019 Jul 30:106432. Epub 2019 Jul 30.

Neurocenter of Southern Switzerland, Civic Hospital, Lugano, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.yebeh.2019.07.033DOI Listing
July 2019

Serum neurofilament light chain in chronic inflammatory demyelinating polyneuropathy.

J Peripher Nerv Syst 2019 Jun 29;24(2):187-194. Epub 2019 Apr 29.

Department of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/jns.12319DOI Listing
June 2019

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis.

JAMA Neurol 2019 Jun 17. Epub 2019 Jun 17.

UCL Institute of Neurology, Queen Square, London, United Kingdom.

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http://dx.doi.org/10.1001/jamaneurol.2019.1534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580449PMC
June 2019

Blood neurofilament light as a potential endpoint in Phase 2 studies in MS.

Ann Clin Transl Neurol 2019 Jun 28;6(6):1081-1089. Epub 2019 May 28.

Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering University Hospital Basel, University of Basel Basel Switzerland.

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http://dx.doi.org/10.1002/acn3.795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562031PMC
June 2019

High-density lipoprotein cholesterol is associated with multiple sclerosis fatigue: A fatigue-metabolism nexus?

J Clin Lipidol 2019 Jul - Aug;13(4):654-663.e1. Epub 2019 Jun 18.

Department of Biotechnical and Clinical Laboratory Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA; Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.

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http://dx.doi.org/10.1016/j.jacl.2019.06.003DOI Listing
June 2019

Serum neurofilament light chain is a biomarker of acute and chronic neuronal damage in early multiple sclerosis.

Mult Scler 2019 04 15;25(5):678-686. Epub 2018 Mar 15.

Department of Neurology and Focus Program Translational Neuroscience (FTN), Research Center for Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1177/1352458518765666DOI Listing
April 2019

Central Slab versus Whole Brain to Measure Brain Atrophy in Multiple Sclerosis.

Eur Neurol 2018 3;80(3-4):207-214. Epub 2019 Jan 3.

Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland,

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https://www.karger.com/Article/FullText/495798
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http://dx.doi.org/10.1159/000495798DOI Listing
March 2019

Blood neurofilament light chain as a biomarker of MS disease activity and treatment response.

Neurology 2019 03 8;92(10):e1007-e1015. Epub 2019 Feb 8.

From the Neurologic Clinic and Policlinic (J.K., C.B., L.K.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel; Novartis Pharma AG (H.K., D.A.H., F.D., D.T., D.L.), Basel, Switzerland; Novartis Healthcare Pvt. Ltd. (U.K.), Hyderabad, India; and DATAMAP GmbH (R.M.), Freiburg, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000007032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442011PMC
March 2019

Patterns of care for Multiple Sclerosis in a setting of universal care access: A cross-sectional study.

Mult Scler Relat Disord 2019 Feb 2;28:17-25. Epub 2018 Dec 2.

Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 84, 8001 Zurich, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22110348183052
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http://dx.doi.org/10.1016/j.msard.2018.11.033DOI Listing
February 2019

Serum glial fibrillary acidic protein correlates with multiple sclerosis disease severity.

Mult Scler 2018 Dec 20:1352458518819380. Epub 2018 Dec 20.

Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland/Division of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland.

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http://dx.doi.org/10.1177/1352458518819380DOI Listing
December 2018

Neurofilament Light Chain: Blood Biomarker of Neonatal Neuronal Injury.

Front Neurol 2018 20;9:984. Epub 2018 Nov 20.

Department of Neonatology, University Children's Hospital Basel, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.3389/fneur.2018.00984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256184PMC
November 2018

The disease burden of Multiple Sclerosis from the individual and population perspective: Which symptoms matter most?

Mult Scler Relat Disord 2018 Oct 21;25:112-121. Epub 2018 Jul 21.

Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.msard.2018.07.013DOI Listing
October 2018

Neurofilaments as biomarkers in neurological disorders.

Nat Rev Neurol 2018 10;14(10):577-589

Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.

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http://www.nature.com/articles/s41582-018-0058-z
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http://dx.doi.org/10.1038/s41582-018-0058-zDOI Listing
October 2018

Serum neurofilament light: A biomarker of neuroaxonal injury after ischemic stroke.

Neurology 2018 10 14;91(14):e1338-e1347. Epub 2018 Sep 14.

From the Institute for Stroke and Dementia Research, University Hospital (S.T., M. Duering, A.G.K., J.B., B.G., F.A.W., M. Dichgans), and Graduate School of Systemic Neurosciences (S.T.), LMU Munich; Munich Cluster for Systems Neurology (SyNergy) (S.T., M. Dichgans), Munich, Germany; Neurologic Clinic and Policlinic (C.B., J.K.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Switzerland; German Center for Neurodegenerative Diseases (DZNE) (F.J.B., G.C.P.), Bonn; Department of Neurology (F.J.B., G.C.P.), University Hospital Bonn; Departments of Neurology (M.K., L.K.), Neuroradiology (F.D.), and Radiology (B.E.-W.), University Hospital, LMU Munich; Department of Neurology (M.W.G.), University of Magdeburg, University Hospital; German Center for Neurodegenerative Diseases (DZNE) (M.W.G.), Magdeburg, Germany; Stroke Center and Department of Neurology (N.P.), University Hospital Basel, Switzerland; and German Center for Neurodegenerative Diseases (DZNE) (M. Dichgans), Munich, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000006282DOI Listing
October 2018

NfL is a biomarker for adult-onset leukoencephalopathy with axonal spheroids and pigmented glia.

Neurology 2018 10 14;91(16):755-757. Epub 2018 Sep 14.

From the Department of Neurodegenerative Diseases (S.N.H., L.S.), Hertie-Institute for Clinical Brain Research & Center of Neurology, University of Tübingen, Germany; German Research Center for Neurodegenerative Diseases (DZNE) (S.N.H., L.S.), Tübingen, Germany; Institute of Human Genetics (I.K., F.R., J.R.L.), University of Leipzig, Germany; Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research (C.B., J.K.), University Hospital Basel, University of Basel, Switzerland; and Department of Neurology (P.K.), University of Magdeburg, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000006357DOI Listing
October 2018

Exploring the effect of vitamin D supplementation on the anti-EBV antibody response in relapsing-remitting multiple sclerosis.

Mult Scler 2018 09 21;24(10):1280-1287. Epub 2017 Jul 21.

School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands/Academic MS Center Limburg, Zuyderland Medical Center, Sittard, The Netherlands.

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http://dx.doi.org/10.1177/1352458517722646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108041PMC
September 2018

Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis.

Brain 2018 08;141(8):2382-2391

Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1093/brain/awy154DOI Listing
August 2018

Serum neurofilament light chain: a biomarker of neuronal injury in vasculitic neuropathy.

Ann Rheum Dis 2018 07 25;77(7):1093-1094. Epub 2017 Jul 25.

Clinic for Rheumatology, Department of Medicine, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1136/annrheumdis-2017-212045DOI Listing
July 2018

Serum neurofilament light is increased in multiple system atrophy of cerebellar type and in repeat-expansion spinocerebellar ataxias: a pilot study.

J Neurol 2018 Jul 8;265(7):1618-1624. Epub 2018 May 8.

Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.

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http://dx.doi.org/10.1007/s00415-018-8893-9DOI Listing
July 2018

Serum neurofilament light chain is increased in hereditary spastic paraplegias.

Ann Clin Transl Neurol 2018 Jul 21;5(7):876-882. Epub 2018 May 21.

Department of Neurodegenerative Diseases Hertie-Institute for Clinical Brain Research and Center of Neurology University of Tübingen Hoppe-Seyler-Str. 3 72076 Tübingen Germany.

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http://dx.doi.org/10.1002/acn3.583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043776PMC
July 2018

Prodromal symptoms of multiple sclerosis in primary care.

Ann Neurol 2018 06 30;83(6):1162-1173. Epub 2018 May 30.

Neurocenter of Southern Switzerland, Civic Hospital, Lugano, Switzerland.

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http://dx.doi.org/10.1002/ana.25247DOI Listing
June 2018

Comparative analysis of natalizumab versus fingolimod as second-line treatment in relapsing-remitting multiple sclerosis.

Mult Scler 2018 05 24;24(6):777-785. Epub 2018 Apr 24.

Neurologic Clinic and Policlinic, Department of Neurology, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1177/1352458518768433DOI Listing
May 2018

Dimethyl fumarate influences innate and adaptive immunity in multiple sclerosis.

J Autoimmun 2018 01 27;86:39-50. Epub 2017 Sep 27.

Laboratory of Clinical Neuroimmunology, Neurologic Clinic and Policlinic, Departments of Biomedicine and Clinical Research, University Hospital Basel and University of Basel, Hebelstrasse 20, 4031, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2017.09.009DOI Listing
January 2018

Neurofilament light chain predicts disease activity in relapsing-remitting MS.

Neurol Neuroimmunol Neuroinflamm 2018 Jan 28;5(1):e422. Epub 2017 Nov 28.

Department of Neurology (K.N.V., K.B., K.-M.M., Ø.T., S.W., L.A.B., C.V.), Haukeland University Hospital; Department of Clinical Medicine (K.N.V., K.-M.M., Ø.T., S.W., L.A.B., C.V.), University of Bergen, Norway; Neurologic Clinic and Policlinic (C.B., J.K.), Departments of Medicine, Clinical Research and Biomedicine, University Hospital Basel, University of Basel, Switzerland; Department of Global Public Health and Primary Care (K.B.), University of Bergen, Norway; and Norwegian MS-Registry & Biobank (K.-M.M.).

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http://dx.doi.org/10.1212/NXI.0000000000000422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707445PMC
January 2018

Multicenter evaluation of neurofilaments in early symptom onset amyotrophic lateral sclerosis.

Neurology 2018 01 6;90(1):e22-e30. Epub 2017 Dec 6.

From the Nuffield Department of Clinical Neurosciences (E.F., E.G., M.R.T.), University of Oxford, UK; Department of Neurology (P.O., P.S., F.V., J.H.W., P.W., A.C.L., M.O.), Ulm University Hospital, Germany; Department of Pathophysiology and Transplantation (F.V., V.S.), Università degli Studi di Milano; Department of Neurology-Stroke Unit and Laboratory of Neuroscience (F.V., C.M., V.S.), IRCCS Istituto Auxologico Italiano, Milan, Italy; Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine (C.B., J.K.), University Hospital and University of Basel, Switzerland; Department of Neurology (P.V.D.) and Laboratory of Molecular Neurobiomarker Research and Laboratory Medicine (K.P.), University Hospitals Leuven; KU Leuven-University of Leuven (P.V.D.); Department of Neurosciences (P.V.D.), VIB-Center for Brain & Disease Research, Leuven, Belgium; Department of Neurology (J.G., P.M., B.S.), Jena University Hospital, Germany; Department of Metabolic Biochemistry (C.J., F.L.) and Neurological Diseases Department (M.d.M.A., F.S.), Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Paris, France; Department of Neurology (S.K., S.P.), Hannover Medical School; Institute for Epidemiology and Medical Biometry (B.M.) Ulm University, Germany; Donders Institute for Brain, Cognition and Behaviour, Department of Neurology (J.R., M.M.V.), and Radboud Alzheimer Center, Department of Laboratory Medicine (M.M.V.), Radboud University Medical Center, Nijmegen, the Netherlands; and Department of Neurodegenerative Disease and Gerontopsychiatry/Neurology (P.W.), Bonn University Hospital, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000004761DOI Listing
January 2018

Serum neurofilament light is sensitive to active cerebral small vessel disease.

Neurology 2017 Nov 18;89(20):2108-2114. Epub 2017 Oct 18.

From the Department of Neurology (T.G., D.P., C.E., T.S.-H., M.K., S.F., A.P., M.V., L.P., E.H., S.R., R.S., F.F., M.K.), Division of Neuroradiology, Vascular and Interventional Radiology (C.E.), and Institute for Medical Informatics, Statistics and Documentation (E.H.), Medical University of Graz, Austria; and Neurologic Clinic and Policlinic (C.B., S.G., J,K.), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, University of Basel, Switzerland.

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http://dx.doi.org/10.1212/WNL.0000000000004645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711505PMC
November 2017

Inflammatory and Neuronal Biomarkers Associated With Retinal Thinning in Pediatric HIV.

Invest Ophthalmol Vis Sci 2017 11;58(13):5985-5992

Department of Hematology, Immunology and Infectious Diseases, Emma Children's Hospital/Academic Medical Center, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1167/iovs.17-22252DOI Listing
November 2017

Fluid biomarker and electrophysiological outcome measures for progressive MS trials.

Mult Scler 2017 Oct;23(12):1600-1613

Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital of Basel, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1177/1352458517732844DOI Listing
October 2017

Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis.

Ann Neurol 2017 Jun;81(6):857-870

Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine, and Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1002/ana.24954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519945PMC
June 2017

Data quality evaluation for observational multiple sclerosis registries.

Mult Scler 2017 Apr 5;23(5):647-655. Epub 2016 Aug 5.

Department of Medicine, University of Melbourne, Melbourne, VIC, Australia/Department of Neurology, Royal Melbourne Hospital, Melbourne, VIC, Australia/Department of Neurology, Box Hill Hospital, Monash University, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1177/1352458516662728DOI Listing
April 2017

Epstein-Barr-negative MS: a true phenomenon?

Neurol Neuroimmunol Neuroinflamm 2017 Mar 3;4(2):e318. Epub 2017 Feb 3.

Blizard Institute (R.D., J.K., G.G.), Queen Mary University London; Department of Neurology (R.D.), St Georges Hospital, London, UK; Neurology, Departments of Medicine (J.K.), Biomedicine and Clinical Research, University Hospital Basel, Switzerland; and Department of Pathology (J.M.), VU University Medical Centre, Amsterdam.

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http://dx.doi.org/10.1212/NXI.0000000000000318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292929PMC
March 2017

Serum neurofilament is associated with progression of brain atrophy and disability in early MS.

Neurology 2017 Feb 1;88(9):826-831. Epub 2017 Feb 1.

From Neurologic Clinic and Policlinic (J.K., C.B., O.Y.), Departments of Medicine, Clinical Research, and Biomedicine, University Hospital Basel, University of Basel, Switzerland; Department of Neurology (B.N., E.W.), University of California San Francisco; Department of Neuroimmunology (D.G.), Queen Square, Institute of Neurology, London; independent statistician (S.M.), Haddenham, Bucks, UK; Department of Neurology (D.P.), University of Southern California, Los Angeles; and Department of Neuroscience and Trauma (G.G., S.G.), Queen Mary University of London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000003653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331872PMC
February 2017

Neurofilament light chain in FTD is elevated not only in cerebrospinal fluid, but also in serum.

J Neurol Neurosurg Psychiatry 2016 11 17;87(11):1270-1272. Epub 2016 May 17.

Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1136/jnnp-2015-312972DOI Listing
November 2016

Serum neurofilament light chain in early relapsing remitting MS is increased and correlates with CSF levels and with MRI measures of disease severity.

Mult Scler 2016 10 11;22(12):1550-1559. Epub 2016 Jan 11.

Advanced Clinical Imaging Technology Group, Siemens Healthcare IM BM PI, Lausanne, Switzerland/Neuro-Immunology, Neurology Division, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland/LTS5, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1177/1352458515623365DOI Listing
October 2016

Neurofilament light chain level is a weak risk factor for the development of MS.

Neurology 2016 Sep 12;87(11):1076-84. Epub 2016 Aug 12.

From Servei de Neurologia-Neuroimmunologia (G.A., C.E., H.E., J.S.-G., E.S., M.C., J.R., C.N., C.T., J.C., A.V.-J., I.G., M.J.A., X.M., M.T.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Barcelona; Universitat Autònoma de Barcelona (G.A., C.E., H.E., J.S.-G., E.S., M.C., J.R., C.N., C.T., J.C., A.V.-J., I.G., X.M., M.T.), Bellaterra; Departments of Neurology and Immunology (L.M.V., J.C.A.-C., C.P.), Multiple Sclerosis Unit, Hospital Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain; Department of Neurology (J.K., L.K.), University Hospital Basel; Neurocentre of Southern Switzerland (G.D.), Ospedale Civico, Lugano, Switzerland; and Magnetic Resonance Unit (IDI) (D.P., C.A., A.R.), Hospital Universitari Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1212/WNL.0000000000003085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027802PMC
September 2016

Comment: "If you can't measure it, you can't improve it" (Lord Kelvin).

Authors:
Jens Kuhle

Neurology 2016 09 31;87(13):1335. Epub 2016 Aug 31.

From Neurology, Departments of Medicine, Clinical Research and Biomedicine, University Hospital Basel, Switzerland.

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http://dx.doi.org/10.1212/WNL.0000000000003164DOI Listing
September 2016

Systemic inflammatory response and neuromuscular involvement in amyotrophic lateral sclerosis.

Neurol Neuroimmunol Neuroinflamm 2016 Aug 1;3(4):e244. Epub 2016 Jun 1.

Centre for Neuroscience & Trauma (C.L., F.O., J.K., A.M.) and Centre of Primary Care and Public Health (V.G.), Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London; Sobell Department of Motor Neuroscience and Movement Disorders (C.L., P.F., L.G.), MRC Centre for Neuromuscular Diseases (P.F., L.G.), MRC Unit for Lifelong Health and Ageing (N.S.), Department of Molecular Neuroscience (K.S.), and Department of Clinical Neuroscience (R.O.), UCL Institute of Neurology; Basildon and Thurrock University Hospitals (K.A., A.M.), NHS Foundation Trust, Basildon; William Harvey Hospital (F.O.), Kent; Proteome Sciences plc (E.L.), South Wing Laboratory, Institute of Psychiatry, UK; Neurology (J.K.), University Hospital Basel, Switzerland; Department of Immunobiology (T.T.), King's College London; National Hospital for Neurology and Neurosurgery (N.S., R.H., R.O.), London; Musgrove Park Hospital (M.F.), Taunton; and Department of Medical Statistics (N.P.), London School of Hygiene and Tropical Medicine, UK.

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http://dx.doi.org/10.1212/NXI.0000000000000244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897985PMC
August 2016

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.

Neuron 2016 07 9;91(1):56-66. Epub 2016 Jun 9.

German Center for Neurodegenerative Diseases (DZNE), Tuebingen, D-72076 Tuebingen, Germany; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, D-72076 Tuebingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.05.018DOI Listing
July 2016

Natalizumab-induced POU2AF1/Spi-B upregulation: A possible route for PML development.

Neurol Neuroimmunol Neuroinflamm 2016 Jun 31;3(3):e223. Epub 2016 Mar 31.

Clinical Neuroimmunology (M.M., C.S., F.H., M.R., B.F.D., J.K., T.D., L.K., R.L.P.L.), Departments of Biomedicine and Neurology, University Hospital Basel, Switzerland; and Department of Neurology (A.H.), St. Josef-Hospital, Ruhr-University Bochum, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821666PMC
June 2016

Neurofilament Light Chain Determination from Peripheral Blood Samples.

Methods Mol Biol 2016 ;1304:93-8

Neurology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.

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May 2016

Severe exacerbation of relapsing-remitting multiple sclerosis after G-CSF therapy.

Neurol Neuroimmunol Neuroinflamm 2016 Apr 9;3(2):e215. Epub 2016 Mar 9.

University Hospital Basel, Switzerland.

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http://dx.doi.org/10.1212/NXI.0000000000000215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794809PMC
April 2016

Multiple Sclerosis and Antibodies against KIR4.1.

N Engl J Med 2016 Apr;374(15):1496-8

University Hospital Basel, Basel, Switzerland

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http://dx.doi.org/10.1056/NEJMc1507131DOI Listing
April 2016

Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children.

Medicine (Baltimore) 2016 Mar;95(12):e3093

From the Department of Pediatric Hematology, Immunology and Infectious Diseases, (YWVD, CB, SC, JATS, HJS, TWK, DP); Psychosocial Department (JATS), Emma Children's Hospital/Academic Medical Center; Neurochemistry Laboratory and Biobank (CET), Department of Clinical Chemistry, VU University Medical Center and Neurocampus Amsterdam, the Netherlands; Neurology (JK), Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, Basel, Switzerland; Department of Experimental Immunology (NAK); Department of Global Health and Amsterdam Institute of Global Health and Development (PR), Academic Medical Center; HIV Monitoring Foundation (PR); Department of Internal Medicine (PR), Division of Infectious Diseases, Center for Infection and Immunity Amsterdam (CINIMA); and Department of Radiology (CBLMM, MWAC), Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1097/MD.0000000000003093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998374PMC
March 2016

Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome.

J Neurol Neurosurg Psychiatry 2016 Feb 25;87(2):126-9. Epub 2015 Feb 25.

Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, London, UK Department of Neurology, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1136/jnnp-2014-309690DOI Listing
February 2016

Quantified CSF antibody reactivity against myelin in multiple sclerosis.

Ann Clin Transl Neurol 2015 12 9;2(12):1116-23. Epub 2015 Nov 9.

Max Planck Institute of Experimental Medicine Göttingen 37075 Germany; Department of Neurology University of Göttingen Göttingen 37075 Germany.

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http://dx.doi.org/10.1002/acn3.264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693593PMC
December 2015

Decision for intravenous thrombolysis in a young patient with acute vertical gaze palsy.

Acta Neurol Belg 2015 Sep 3;115(3):445-7. Epub 2014 Sep 3.

Department of Neurology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland,

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http://dx.doi.org/10.1007/s13760-014-0356-1DOI Listing
September 2015

CSF neurofilament light chain reflects corticospinal tract degeneration in ALS.

Ann Clin Transl Neurol 2015 Jul 25;2(7):748-55. Epub 2015 May 25.

Nuffield Department of Clinical Neurosciences, University of Oxford Oxford, United Kingdom.

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http://dx.doi.org/10.1002/acn3.212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531057PMC
July 2015

The refinement of genetic predictors of multiple sclerosis.

PLoS One 2014 2;9(5):e96578. Epub 2014 May 2.

Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096578PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008598PMC
June 2015

Neurofilament light chain: A prognostic biomarker in amyotrophic lateral sclerosis.

Neurology 2015 Jun 1;84(22):2247-57. Epub 2015 May 1.

From the Centre for Neuroscience & Trauma (C.-H.L., G.G., J.K., A.M.), Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London; Sobell Department of Motor Neuroscience and Movement Disorders (C.-H.L., L.G.), Departments of Neuroinflammation (A.P.), Neurodegenerative Disease (P.F.), Molecular Neuroscience (K.S.), and Clinical Neuroscience (R.O.), and MRC Centre for Neuromuscular Diseases (R.O., L.G.), UCL Institute of Neurology, London; MRC Integrative Epidemiology Unit (C.M.-W.), University of Bristol; Nuffield Department of Clinical Neurosciences (E.G., K.T., M.R.T.), University of Oxford; Department of Medical Statistics (N.P.), London School of Hygiene and Tropical Medicine, London, UK; UmanDiagnostics (N.N.), Umeå, Sweden; Medicine Clinical Trial Unit (M.F.), Musgrove Park Hospital, Taunton, UK; National Hospital for Neurology and Neurosurgery (R.O., R.H., A.M.), London, UK; Neurology (J.K.), University Hospital Basel, Switzerland; North-East London and Essex MND Care and Research Centre (A.M.), London; and Basildon and Thurrock University Hospitals NHS Foundation Trust (A.M.), Basildon, UK.

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http://dx.doi.org/10.1212/WNL.0000000000001642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456658PMC
June 2015

Plasma neurofilament heavy chain levels and disease progression in amyotrophic lateral sclerosis: insights from a longitudinal study.

J Neurol Neurosurg Psychiatry 2015 May 9;86(5):565-73. Epub 2014 Jul 9.

Centre for Neuroscience & Trauma, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK Basildon and Thurrock University Hospitals NHS Foundation Trust, Essex, UK North-East London and Essex MND Care and Research Centre, London, UK.

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http://dx.doi.org/10.1136/jnnp-2014-307672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413806PMC
May 2015

Fingolimod and CSF neurofilament light chain levels in relapsing-remitting multiple sclerosis.

Neurology 2015 Apr 25;84(16):1639-43. Epub 2015 Mar 25.

From the Neuroimmunology Unit (J.K., G.D., G.G.), Blizard Institute, Barts and the London School of Medicine and Dentistry, London, UK; Neurology, Departments of Medicine, Clinical Research and Biomedicine (J.K., J.L., L.K.), and the Medical Image Analysis Center (MIAC) (E.-W.R.), University Hospital, Basel, Switzerland; Novartis Pharmaceuticals Corporation (T.S., Y.C., G.F.), East Hanover, NJ; Novartis Pharma AG (F.D.), Basel, Switzerland; and Novartis Healthcare Pvt Ltd (A.S.), Hyderabad, India.

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http://dx.doi.org/10.1212/WNL.0000000000001491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409586PMC
April 2015

Unraveling natalizumab effects on deregulated miR-17 expression in CD4+ T cells of patients with relapsing-remitting multiple sclerosis.

J Immunol Res 2014 12;2014:897249. Epub 2014 May 12.

Clinical Neuroimmunology, Departments of Biomedicine and Neurology, University Hospital Basel, Hebelstrasse 20, 4031 Basel, Switzerland.

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http://dx.doi.org/10.1155/2014/897249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036714PMC
December 2014

Neurofilament light antibodies in serum reflect response to natalizumab treatment in multiple sclerosis.

Mult Scler 2014 Sep 10;20(10):1355-62. Epub 2014 Feb 10.

Neuroimmunology Unit, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK

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http://journals.sagepub.com/doi/10.1177/1352458514521887
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http://dx.doi.org/10.1177/1352458514521887DOI Listing
September 2014

MiR-126: a novel route for natalizumab action?

Mult Scler 2014 Sep 5;20(10):1363-70. Epub 2014 Mar 5.

University Hospital Basel, University of Basel, Switzerland

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http://dx.doi.org/10.1177/1352458514524998DOI Listing
September 2014

Immune reactivity to neurofilament proteins in the clinical staging of amyotrophic lateral sclerosis.

J Neurol Neurosurg Psychiatry 2014 Mar 27;85(3):274-8. Epub 2013 Sep 27.

Neuroimmunology Unit, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, , London, UK.

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http://dx.doi.org/10.1136/jnnp-2013-305494DOI Listing
March 2014

DNase hypersensitive sites and association with multiple sclerosis.

Hum Mol Genet 2014 Feb 2;23(4):942-8. Epub 2013 Oct 2.

Department of Physiology, Anatomy and Genetics and Medical Research Council Functional Genomics Unit, University of Oxford, South Parks Road, Oxford OX1 3PT, UK.

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http://dx.doi.org/10.1093/hmg/ddt489DOI Listing
February 2014