Jens Juul Holst

Jens Juul Holst

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Jens Juul Holst

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Habitual activity associates with lower fasting and greater glucose-induced GLP-1 response in men.

Authors:
Charlotte Janus Dorte Vistisen Hanan Amadid Daniel R Witte Torsten Lauritzen Søren Brage Anne-Louise Bjerregaard Torben Hansen Jens Juul Holst Marit Eika Jørgensen Oluf Pedersen Kristine Færch Signe Torekov

Endocr Connect 2019 Dec 1. Epub 2019 Dec 1.

S Torekov, Copenhagen, Denmark.

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http://dx.doi.org/10.1530/EC-19-0408DOI Listing
December 2019

Incretin therapy for diabetes mellitus type 2.

Authors:
Jens Juul Holst

Curr Opin Endocrinol Diabetes Obes 2019 Dec 4. Epub 2019 Dec 4.

NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, The Panum Institute, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen N, Denmark.

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http://dx.doi.org/10.1097/MED.0000000000000516DOI Listing
December 2019

Protocol for a randomised controlled trial of the combined effects of the GLP-1 receptor agonist liraglutide and exercise on maintenance of weight loss and health after a very low-calorie diet.

Authors:
Simon Birk Kjær Jensen Julie Rehné Lundgren Charlotte Janus Christian Rimer Juhl Lisa Møller Olsen Mads Rosenkilde Jens Juul Holst Bente Merete Stallknecht Sten Madsbad Signe Sørensen Torekov

BMJ Open 2019 Nov 2;9(11):e031431. Epub 2019 Nov 2.

Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

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http://dx.doi.org/10.1136/bmjopen-2019-031431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830609PMC
November 2019

A Low Dose of Pasireotide Prevents Hypoglycemia in Roux-en-Y Gastric Bypass-Operated Individuals.

Authors:
Caroline C Øhrstrøm Dorte L Hansen Urd Lynge Kielgast Bolette Hartmann Jens Juul Holst Dorte Worm

Obes Surg 2019 Nov 10. Epub 2019 Nov 10.

Department of Medicine, Amager Hospital, Amager, Denmark.

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http://dx.doi.org/10.1007/s11695-019-04248-xDOI Listing
November 2019

Correction to: Effects of glucagon-like peptide 1 analogs on alcohol intake in alcohol-preferring vervet monkeys.

Authors:
Morgane Thomsen Jens Juul Holst Anna Molander Kristian Linnet Maurice Ptito Anders Fink-Jensen

Psychopharmacology (Berl) 2019 Nov 25. Epub 2019 Nov 25.

Laboratory of Neuropsychiatry, Psychiatric Centre Copenhagen and University Hospital of Copenhagen, Edel Sauntes Allé 10, DK-2100, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s00213-019-05374-1DOI Listing
November 2019

Ghrelin does not directly stimulate secretion of glucagon-like peptide-1.

Authors:
Sara Lind Jepsen Esben Thyssen Vestergaard Pierre Larraufie Fiona Mary Gribble Frank Reimann Jens Otto Lunde Jørgensen Jens Juul Holst Rune Ehrenreich Kuhre

J Clin Endocrinol Metab 2019 Oct 14. Epub 2019 Oct 14.

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1210/clinem/dgz046DOI Listing
October 2019

Effects of Exercise Training and IL-6 Receptor Blockade on Gastric Emptying and GLP-1 Secretion in Obese Humans: Secondary Analyses From a Double Blind Randomized Clinical Trial.

Authors:
Louise Lang Lehrskov Regitse Højgaard Christensen Anne-Sophie Wedell-Neergaard Grit Elster Legaard Emma Dorph Monica Korsager Larsen Marie Henneberg Natja Launbo Sabrina Ravn Fagerlind Sidsel Kofoed Seide Stine Nymand Maria Ball Nicole Vinum Camilla Dahl Nicolai Jacob Wewer Albrechtsen Jens Juul Holst Mathias Ried-Larsen Jaya Birgitte Rosenmeier Rikke Krogh-Madsen Kristian Karstoft Bente Klarlund Pedersen Helga Ellingsgaard

Front Physiol 2019 4;10:1249. Epub 2019 Oct 4.

Centre of Inflammation and Metabolism, Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.3389/fphys.2019.01249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787899PMC
October 2019

A Pilot Study Showing Acute Inhibitory Effect of GLP-1 on the Bone Resorption Marker CTX in Humans.

Authors:
Anne Nissen Simone Marstrand Kirsa Skov-Jeppesen Lasse Bremholm Mads Hornum Ulrik B Andersen Jens Juul Holst Mette Marie Rosenkilde Bolette Hartmann

JBMR Plus 2019 Oct 23;3(10):e10209. Epub 2019 Aug 23.

Department of Biomedical Sciences The Panum Institute, University of Copenhagen Copenhagen Denmark.

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http://dx.doi.org/10.1002/jbm4.10209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820456PMC
October 2019

Postprandial hypoglycaemia after Roux-en-Y gastric bypass and the effects of acarbose, sitagliptin, verapamil, liraglutide and pasireotide.

Authors:
Caroline Christfort Øhrstrøm Dorte Worm Anna Højager Ditte Andersen Jens Juul Holst Urd Lynge Kielgast Dorte Lindqvist Hansen

Diabetes Obes Metab 2019 Sep 24;21(9):2142-2151. Epub 2019 Jun 24.

Clinical Department, Steno Diabetes Center, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/dom.13796DOI Listing
September 2019

Gluco-metabolic effects of oral and intravenous alcohol administration in men.

Authors:
Amalie Rasmussen Rasmussen Lanng Lærke Smidt Gasbjerg Natasha Chidekel Bergmann Sigrid Bermann Mads Marstand Helsted Matthew Paul Gillum Bolette Hartmann Jens Juul Holst Tina Vilsbøll Filip K Knop

Endocr Connect 2019 Sep 1. Epub 2019 Sep 1.

F Knop, Center for Clinical Metabolic Research , Gentofte University Hospital, Hellerup, Denmark.

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http://dx.doi.org/10.1530/EC-19-0317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790903PMC
September 2019

Augmented GLP-1 Secretion as Seen After Gastric Bypass May Be Obtained by Delaying Carbohydrate Digestion.

Authors:
Christoffer Martinussen Kristine Nyvold Bojsen-Møller Carsten Dirksen Maria Saur Svane Viggo Bjerregaard Kristiansen Bolette Hartmann Jens Juul Holst Sten Madsbad

J Clin Endocrinol Metab 2019 Aug;104(8):3233-3244

Department of Endocrinology, Hvidovre Hospital, Hvidovre, Denmark.

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https://academic.oup.com/jcem/advance-article/doi/10.1210/jc
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http://dx.doi.org/10.1210/jc.2018-02661DOI Listing
August 2019

Gastric Emptying and Distal Gastrectomy Independently Enhance Postprandial Glucagon-Like Peptide-1 Release After a Mixed Meal and Improve Glycemic Control in Subjects Having Undergone Pancreaticoduodenectomy.

Authors:
Emanuel Steiner Robert Breuer Lukas Kazianka Marlene Wewalka Thomas Stimpfl Birgit Reiter Jens Juul Holst Johannes Miholic

Pancreas 2019 08;48(7):953-957

From the Department of Surgery.

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http://dx.doi.org/10.1097/MPA.0000000000001361DOI Listing
August 2019

The imprinted gene Delta like non-canonical notch ligand 1 (Dlk1) associates with obesity and triggers insulin resistance through inhibition of skeletal muscle glucose uptake.

Authors:
Charlotte Harken Jensen Rok Kosmina Mikael Rydén Christina Baun Svend Hvidsten Marianne Skovsager Andersen Louise Lehmann Christensen Amalia Gastaldelli Paolo Marraccini Peter Arner Christian Damsgaard Jørgensen Jorge Laborda Jens Juul Holst Ditte Caroline Andersen

EBioMedicine 2019 Aug 3;46:368-380. Epub 2019 Aug 3.

Laboratory of Molecular and Cellular Cardiology, Dep. of Clinical Biochemistry and Pharmacology, Odense University Hospital, Denmark; Danish Center for Regenerative Medicine (danishcrm.com), Odense University Hospital, Denmark; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; Clinical Institute, University of Southern Denmark, Odense, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.07.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711890PMC
August 2019

Increased Body Weight and Fat Mass After Subchronic GIP Receptor Antagonist, but Not GLP-2 Receptor Antagonist, Administration in Rats.

Authors:
Sara Baldassano Lærke Smidt Gasbjerg Hüsün Sheyma Kizilkaya Mette Marie Rosenkilde Jens Juul Holst Bolette Hartmann

Front Endocrinol (Lausanne) 2019 6;10:492. Epub 2019 Aug 6.

Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.3389/fendo.2019.00492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691063PMC
August 2019

Short-chain fatty acids and regulation of pancreatic endocrine secretion in mice.

Authors:
Anne Ørgaard Sara Lind Jepsen Jens Juul Holst

Islets 2019 30;11(5):103-111. Epub 2019 Aug 30.

The Novo Nordisk Foundation Center for Basic Metabolic Research, Translational Metabolic Physiology, Faculty of Health Sciences, University of Copenhagen , Copenhagen , Denmark.

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http://dx.doi.org/10.1080/19382014.2019.1587976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773373PMC
August 2019

Instrumentalization of Eating Improves Weight Loss Maintenance in Obesity.

Authors:
Bodil Just Christensen Eva Winning Iepsen Julie Lundgren Lotte Holm Sten Madsbad Jens Juul Holst Signe Sørensen Torekov

Obes Facts 2017 6;10(6):633-647. Epub 2017 Dec 6.

Institute of Food and Resource Economics, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1159/000481138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836264PMC
July 2019

Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients.

Authors:
Esben Thyssen Vestergaard Astrid Johanneson Hjelholt Rune E Kuhre Niels Møller Pierre Larraufie Fiona M Gribble Frank Reimann Niels Jessen Jens Juul Holst Jens Otto Lunde Jørgensen

J Clin Endocrinol Metab 2019 Jul;104(7):2581-2592

Medical Research Laboratories Aarhus University, Aarhus N, Denmark.

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http://dx.doi.org/10.1210/jc.2018-02503DOI Listing
July 2019

Separate and Combined Effects of GIP and GLP-1 Infusions on Bone Metabolism in Overweight Men Without Diabetes.

Authors:
Natasha Chidekel Bergmann Asger Lund Lærke Smidt Gasbjerg Niklas Rye Jørgensen Lene Jessen Bolette Hartmann Jens Juul Holst Mikkel Bring Christensen Tina Vilsbøll Filip Krag Knop

J Clin Endocrinol Metab 2019 Jul;104(7):2953-2960

Clinical Metabolic Physiology, Steno Diabetes Center Copenhagen, Gentofte Hospital, Hellerup, Denmark.

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http://dx.doi.org/10.1210/jc.2019-00008DOI Listing
July 2019

Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia.

Authors:
Christopher M Mulla Allison B Goldfine Jonathan M Dreyfuss Sander Houten Hui Pan David M Pober Nicolai J Wewer Albrechtsen Maria S Svane Julie B Schmidt Jens Juul Holst Colleen M Craig Tracey L McLaughlin Mary-Elizabeth Patti

Obes Surg 2019 Jul;29(7):2092-2099

Research Division, Joslin Diabetes Center, and Harvard Medical School, 1 Joslin Place, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1007/s11695-019-03845-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544487PMC
July 2019

The incretin system in healthy humans: The role of GIP and GLP-1.

Authors:
Jens Juul Holst

Metabolism 2019 Jul 25;96:46-55. Epub 2019 Apr 25.

The NNF center for Basic Metabolic Research and Department of Biomedical Sciences, the Panum Institute, University of Copenhagen, DK-2200, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2019.04.014DOI Listing
July 2019

Which to choose, an oral or an injectable glucagon-like peptide-1 receptor agonist?

Authors:
Jens Juul Holst

Lancet 2019 07 8;394(10192):4-6. Epub 2019 Jun 8.

Department of Biomedical Sciences and NNF Center for Basic Metabolic Research, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(19)31350-9DOI Listing
July 2019

Pros and cons of Roux en-Y gastric bypass surgery in obese patients with type 2 diabetes.

Authors:
Tummas Justinussen Sten Madsbad Jens Juul Holst Kirstine Nyvold Bojsen-Møller

Expert Rev Endocrinol Metab 2019 07 19;14(4):243-257. Epub 2019 Jun 19.

a Department of Endocrinology , Copenhagen University Hospital Hvidovre , Hvidovre , Denmark.

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http://dx.doi.org/10.1080/17446651.2019.1628639DOI Listing
July 2019

Glucagon-Like Peptide-1 Is a Marker of Systemic Inflammation in Patients Treated with High-Dose Chemotherapy and Autologous Stem Cell Transplantation.

Authors:
Maria Schou Ebbesen Hannelouise Kissow Bolette Hartmann Kathrine Grell Jette Sønderskov Gørløv Katrine Kielsen Jens Juul Holst Klaus Müller

Biol Blood Marrow Transplant 2019 06 5;25(6):1085-1091. Epub 2019 Feb 5.

Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark; Institute for Inflammation Research, University Hospital Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.bbmt.2019.01.036DOI Listing
June 2019

Postprandial levels of GLP-1, GIP and glucagon after 2 years of weight loss with a Paleolithic diet: a randomised controlled trial in healthy obese women.

Authors:
Julia Otten Mats Ryberg Caroline Mellberg Tomas Andersson Elin Chorell Bernt Lindahl Christel Larsson Jens Juul Holst Tommy Olsson

Eur J Endocrinol 2019 Jun;180(6):417-427

Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.

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http://dx.doi.org/10.1530/EJE-19-0082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528411PMC
June 2019

The diurnal variation of bone formation is attenuated in adult patients with type 2 diabetes.

Authors:
Katrine Hygum Jakob Kau Starup-Linde Torben Harsløf Niklas Rye Joergensen Bolette Hartmann Jens Juul Holst Bente Langdahl

Eur J Endocrinol 2019 Jun 1. Epub 2019 Jun 1.

B Langdahl, Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus N, Denmark.

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http://dx.doi.org/10.1530/EJE-19-0309DOI Listing
June 2019

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents.

Authors:
Charlotte Bayer Christiansen Samuel Addison Jack Trammell Nicolai Jacob Wewer Albrechtsen Kristina Schoonjans Reidar Albrechtsen Matthew Paul Gillum Rune Ehrenreich Kuhre Jens Juul Holst

Am J Physiol Gastrointest Liver Physiol 2019 May 15;316(5):G574-G584. Epub 2019 Feb 15.

Novo Nordic Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark.

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https://www.physiology.org/doi/10.1152/ajpgi.00010.2019
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http://dx.doi.org/10.1152/ajpgi.00010.2019DOI Listing
May 2019

Effect of liraglutide on body weight and microvascular function in non-diabetic overweight women with coronary microvascular dysfunction.

Authors:
Hannah Elena Suhrs Kristoffer Flintholm Raft Kira Bové Steen Madsbad Jens Juul Holst Mette Zander Eva Prescott

Int J Cardiol 2019 05 2;283:28-34. Epub 2019 Jan 2.

Department of Cardiology, Bispebjerg University Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.ijcard.2018.12.005DOI Listing
May 2019

GIP-induced vasodilation in human adipose tissue involves capillary recruitment.

Authors:
Meena Asmar Ali Asmar Lene Simonsen Flemming Dela Jens Juul Holst Jens Bülow

Endocr Connect 2019 May 1. Epub 2019 May 1.

J Bülow, Department of Clinical Physiology/Nuclear Medicine, Bispebjerg Hospital, Kobenhavn, Denmark.

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http://dx.doi.org/10.1530/EC-19-0144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590203PMC
May 2019

Liraglutide improves the beta-cell function without increasing insulin secretion during a mixed meal in patients, who exhibit well-controlled type 2 diabetes and coronary artery disease.

Authors:
Christian Anholm Preman Kumarathurai Anders Jürs Lene Rørholm Pedersen Olav Wendelboe Nielsen Ole Peter Kristiansen Mogens Fenger Jens Juul Holst Sten Madsbad Ahmad Sajadieh Steen Bendix Haugaard

Diabetol Metab Syndr 2019 31;11:42. Epub 2019 May 31.

1Department of Internal Medicine, Copenhagen University Hospital Glostrup, Nordre Ringvej 57, 2600 Glostrup, Denmark.

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http://dx.doi.org/10.1186/s13098-019-0438-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543623PMC
May 2019

Effects of active commuting and leisure-time exercise on appetite in individuals with overweight and obesity.

Authors:
Jonas Salling Quist Martin Bæk Blond Anne Sofie Gram Carina Bjørnskov Steenholt Charlotte Janus Jens Juul Holst Jens F Rehfeld Anders Sjödin Bente Stallknecht Mads Rosenkilde

J Appl Physiol (1985) 2019 Apr 3;126(4):941-951. Epub 2019 Jan 3.

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark.

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https://www.physiology.org/doi/10.1152/japplphysiol.00239.20
Publisher Site
http://dx.doi.org/10.1152/japplphysiol.00239.2018DOI Listing
April 2019

Peptone-mediated glucagon-like peptide-1 secretion depends on intestinal absorption and activation of basolaterally located Calcium-Sensing Receptors.

Authors:
Ida M Modvig Rune E Kuhre Jens Juul Holst

Physiol Rep 2019 04;7(8):e14056

Department of Biomedical Sciences, NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.14814/phy2.14056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482282PMC
April 2019

Liraglutide-Induced Weight Loss May be Affected by Autonomic Regulation in Type 1 Diabetes.

Authors:
Christian Stevns Hansen Christian Seerup Frandsen Jesper Fleischer Dorte Vistisen Jens Juul Holst Lise Tarnow Filip Krag Knop Sten Madsbad Henrik Ullits Andersen Thomas Fremming Dejgaard

Front Endocrinol (Lausanne) 2019 12;10:242. Epub 2019 Apr 12.

Steno Diabetes Center Copenhagen, Gentofte, Denmark.

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http://dx.doi.org/10.3389/fendo.2019.00242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473101PMC
April 2019

From the Incretin Concept and the Discovery of GLP-1 to Today's Diabetes Therapy.

Authors:
Jens Juul Holst

Front Endocrinol (Lausanne) 2019 26;10:260. Epub 2019 Apr 26.

Department of Biomedical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.3389/fendo.2019.00260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497767PMC
April 2019

A pre-meal of whey proteins induces differential effects on glucose and lipid metabolism in subjects with the metabolic syndrome: a randomised cross-over trial.

Authors:
Ann Bjørnshave Jens Juul Holst Kjeld Hermansen

Eur J Nutr 2019 Mar 6;58(2):755-764. Epub 2018 Apr 6.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Tage-Hansens Gade 2, 8000, Aarhus C, Denmark.

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http://dx.doi.org/10.1007/s00394-018-1684-3DOI Listing
March 2019

Neuromedin U Does Not Act as a Decretin in Rats.

Authors:
Rune Ehrenreich Kuhre Charlotte Bayer Christiansen Seyed Mojtaba Ghiasi Maria Buur Nordskov Gabe Patricia Almine Skat-Rørdam Ida Marie Modvig Thomas Mandrup-Poulsen Reidar Albrechtsen Mette Marie Rosenkilde Bolette Hartmann Nicolai Jacob Wewer Albrechtsen Jens Juul Holst

Cell Metab 2019 03 15;29(3):719-726.e5. Epub 2018 Nov 15.

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Panum Institute, Blegdamsvej 3B, 12.2, 2200 Copenhagen N, Denmark; NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.10.008DOI Listing
March 2019

The effect of DPP-4-protected GLP-1 (7-36) on coronary microvascular function in obese adults.

Authors:
Malin Nilsson Kira Bang Bové Elena Suhrs Thomas Hermann Sten Madsbad Jens Juul Holst Eva Prescott Mette Zander

Int J Cardiol Heart Vasc 2019 Mar 29;22:139-144. Epub 2019 Jan 29.

Department of Endocrinology, Bispebjerg University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.ijcha.2019.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356020PMC
March 2019

Long-acting glucagon-like peptide-1 receptor agonist-status December 2018.

Authors:
Jens Juul Holst

Ann Transl Med 2019 Mar;7(5):83

Department of Biomedical Sciences and NNF center for Basic Metabolic Research, The Panum Institute, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.21037/atm.2019.01.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462657PMC
March 2019

Effects of glucagon-like peptide 1 analogs on alcohol intake in alcohol-preferring vervet monkeys.

Authors:
Morgane Thomsen Jens Juul Holst Anna Molander Kristian Linnet Maurice Ptito Anders Fink-Jensen

Psychopharmacology (Berl) 2019 Feb 31;236(2):603-611. Epub 2018 Oct 31.

Laboratory of Neuropsychiatry, Psychiatric Centre Copenhagen and University Hospital of Copenhagen, Edel Sauntes Allé 10, DK-2100, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s00213-018-5089-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428196PMC
February 2019

Gut Hormones and Their Effect on Bone Metabolism. Potential Drug Therapies in Future Osteoporosis Treatment.

Authors:
Sine Paasch Schiellerup Kirsa Skov-Jeppesen Johanne Agerlin Windeløv Maria Saur Svane Jens Juul Holst Bolette Hartmann Mette Marie Rosenkilde

Front Endocrinol (Lausanne) 2019 26;10:75. Epub 2019 Feb 26.

Laboratory of Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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https://www.frontiersin.org/article/10.3389/fendo.2019.00075
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http://dx.doi.org/10.3389/fendo.2019.00075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399108PMC
February 2019

Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial.

Authors:
Henrik Munch Roager Josef K Vogt Mette Kristensen Lea Benedicte S Hansen Sabine Ibrügger Rasmus B Mærkedahl Martin Iain Bahl Mads Vendelbo Lind Rikke L Nielsen Hanne Frøkiær Rikke Juul Gøbel Rikard Landberg Alastair B Ross Susanne Brix Jesper Holck Anne S Meyer Morten H Sparholt Anders F Christensen Vera Carvalho Bolette Hartmann Jens Juul Holst Jüri Johannes Rumessen Allan Linneberg Thomas Sicheritz-Pontén Marlene D Dalgaard Andreas Blennow Henrik Lauritz Frandsen Silas Villas-Bôas Karsten Kristiansen Henrik Vestergaard Torben Hansen Claus T Ekstrøm Christian Ritz Henrik Bjørn Nielsen Oluf Borbye Pedersen Ramneek Gupta Lotte Lauritzen Tine Rask Licht

Gut 2019 01 1;68(1):83-93. Epub 2017 Nov 1.

National Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark.

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http://dx.doi.org/10.1136/gutjnl-2017-314786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839833PMC
January 2019

WITHDRAWN: Glucose-Dependent Insulinotropic Polypeptide Increases Blood Flow in Adipose Tissue of Humans by Recruiting Capillaries.

Authors:
Meena Asmar Ali Asmar Lene Simonsen Jens Juul Holst Jens Bülow

J Clin Endocrinol Metab 2019 01;104(1):W1-W9

Department of Clinical Physiology/Nuclear Medicine, Bispebjerg University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1210/jc.2018-00389DOI Listing
January 2019

Pre-meal and postprandial lipaemia in subjects with the metabolic syndrome: effects of timing and protein quality (randomised crossover trial).

Authors:
Ann Bjørnshave Trine Nygaard Johansen Bashar Amer Trine Kastrup Dalsgaard Jens Juul Holst Kjeld Hermansen

Br J Nutr 2019 Jan 2:1-10. Epub 2019 Jan 2.

1Department of Endocrinology and Internal Medicine,Aarhus University Hospital,Aarhus,Denmark.

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http://dx.doi.org/10.1017/S0007114518003264DOI Listing
January 2019

Endogenous glucagon-like peptide- 1 and 2 are essential for regeneration after acute intestinal injury in mice.

Authors:
Rasmus Hytting-Andreasen Emilie Balk-Møller Bolette Hartmann Jens Pedersen Johanne Agerlin Windeløv Jens Juul Holst Hannelouise Kissow

PLoS One 2018 4;13(6):e0198046. Epub 2018 Jun 4.

Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198046PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986149PMC
December 2018

Response to Letter to the Editor: "Hemodynamic Effects of Glucagon: A Literature Review".

Authors:
Kasper Meidahl Petersen Søren Bøgevig Jens Juul Holst Filip Krag Knop Mikkel Bring Christensen

J Clin Endocrinol Metab 2018 12;103(12):4480-4481

Department of Clinical Pharmacology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1210/jc.2018-01825DOI Listing
December 2018

Hepatic Insulin Clearance in Regulation of Systemic Insulin Concentrations-Role of Carbohydrate and Energy Availability.

Authors:
Kirstine N Bojsen-Møller Anne-Marie Lundsgaard Sten Madsbad Bente Kiens Jens Juul Holst

Diabetes 2018 11;67(11):2129-2136

Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db18
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http://dx.doi.org/10.2337/db18-0539DOI Listing
November 2018

A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults.

Authors:
Lea B S Hansen Henrik M Roager Nadja B Søndertoft Rikke J Gøbel Mette Kristensen Mireia Vallès-Colomer Sara Vieira-Silva Sabine Ibrügger Mads V Lind Rasmus B Mærkedahl Martin I Bahl Mia L Madsen Jesper Havelund Gwen Falony Inge Tetens Trine Nielsen Kristine H Allin Henrik L Frandsen Bolette Hartmann Jens Juul Holst Morten H Sparholt Jesper Holck Andreas Blennow Janne Marie Moll Anne S Meyer Camilla Hoppe Jørgen H Poulsen Vera Carvalho Domenico Sagnelli Marlene D Dalgaard Anders F Christensen Magnus Christian Lydolph Alastair B Ross Silas Villas-Bôas Susanne Brix Thomas Sicheritz-Pontén Karsten Buschard Allan Linneberg Jüri J Rumessen Claus T Ekstrøm Christian Ritz Karsten Kristiansen H Bjørn Nielsen Henrik Vestergaard Nils J Færgeman Jeroen Raes Hanne Frøkiær Torben Hansen Lotte Lauritzen Ramneek Gupta Tine Rask Licht Oluf Pedersen

Nat Commun 2018 11 13;9(1):4630. Epub 2018 Nov 13.

The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200, Copenhagen, Denmark.

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http://www.nature.com/articles/s41467-018-07019-x
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http://dx.doi.org/10.1038/s41467-018-07019-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234216PMC
November 2018

Insulin Secretion Depends on Intra-islet Glucagon Signaling.

Authors:
Berit Svendsen Olav Larsen Maria Buur Nordskov Gabe Charlotte Bayer Christiansen Mette M Rosenkilde Daniel J Drucker Jens Juul Holst

Cell Rep 2018 10;25(5):1127-1134.e2

NovoNordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.celrep.2018.10.018DOI Listing
October 2018

The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon.

Authors:
Charlotte Bayer Christiansen Maria Buur Nordskov Gabe Berit Svendsen Lars Ove Dragsted Mette Marie Rosenkilde Jens Juul Holst

Am J Physiol Gastrointest Liver Physiol 2018 07 1;315(1):G53-G65. Epub 2018 Mar 1.

Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen , Copenhagen , Denmark.

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https://www.physiology.org/doi/10.1152/ajpgi.00346.2017
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http://dx.doi.org/10.1152/ajpgi.00346.2017DOI Listing
July 2018

Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control.

Authors:
Louise Lang Lehrskov Mark Preben Lyngbaek Line Soederlund Grit Elster Legaard Jan Adam Ehses Sarah Elizabeth Heywood Nicolai Jacob Wewer Albrechtsen Jens Juul Holst Kristian Karstoft Bente Klarlund Pedersen Helga Ellingsgaard

Cell Metab 2018 Jun 3;27(6):1201-1211.e3. Epub 2018 May 3.

The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183025
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http://dx.doi.org/10.1016/j.cmet.2018.04.008DOI Listing
June 2018

Non-insulin pharmacological therapies for treating type 1 diabetes.

Authors:
Christian Seerup Frandsen Thomas Fremming Dejgaard Sten Madsbad Jens Juul Holst

Expert Opin Pharmacother 2018 06;19(9):947-960

c Department of Biomedical Sciences and NNF Center for Basic Metabolic Research , University of Copenhagen , Copenhagen , Denmark.

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http://dx.doi.org/10.1080/14656566.2018.1483339DOI Listing
June 2018

Patient profiling for success after weight loss surgery (GO Bypass study): An interdisciplinary study protocol.

Authors:
Bodil Just Christensen Julie Berg Schmidt Mette Søndergaard Nielsen Louise Tækker Lotte Holm Susanne Lunn Wender L P Bredie Christian Ritz Jens Juul Holst Torben Hansen Anja Hilbert Carel W le Roux Oliver J Hulme Hartwig Siebner Tobias Morville Lars Naver Andrea Karen Floyd Anders Sjödin

Contemp Clin Trials Commun 2018 Jun 17;10:121-130. Epub 2018 Feb 17.

Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.conctc.2018.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046467PMC
June 2018

Hemodynamic Effects of Glucagon: A Literature Review.

Authors:
Kasper Meidahl Petersen Søren Bøgevig Jens Juul Holst Filip Krag Knop Mikkel Bring Christensen

J Clin Endocrinol Metab 2018 05;103(5):1804-1812

Department of Clinical Pharmacology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1210/jc.2018-00050DOI Listing
May 2018

Mechanisms in bariatric surgery: Gut hormones, diabetes resolution, and weight loss.

Authors:
Jens Juul Holst Sten Madsbad Kirstine N Bojsen-Møller Maria Saur Svane Nils Bruun Jørgensen Carsten Dirksen Christoffer Martinussen

Surg Obes Relat Dis 2018 05 8;14(5):708-714. Epub 2018 Mar 8.

NNF Center for Basic Metabolic Research and Dept. Biomedical Sciences, the Panum Institute, University of Copenhagen, Copenhagen, Denmark; Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.soard.2018.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974695PMC
May 2018

Effects of Preceding Ethanol Intake on Glucose Response to Low-Dose Glucagon in Individuals With Type 1 Diabetes: A Randomized, Placebo-Controlled, Crossover Study.

Authors:
Ajenthen Ranjan Kirsten Nørgaard Rikke Tetzschner Isabelle Isa Kristin Steineck Trine Ryberg Clausen Jens Juul Holst Sten Madsbad Signe Schmidt

Diabetes Care 2018 04 22;41(4):797-806. Epub 2018 Jan 22.

Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.

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http://dx.doi.org/10.2337/dc17-1458DOI Listing
April 2018

Effects of a diet rich in arabinoxylan and resistant starch compared with a diet rich in refined carbohydrates on postprandial metabolism and features of the metabolic syndrome.

Authors:
Anne Grethe Schioldan Søren Gregersen Stine Hald Ann Bjørnshave Mette Bohl Bolette Hartmann Jens Juul Holst Hans Stødkilde-Jørgensen Kjeld Hermansen

Eur J Nutr 2018 Mar 9;57(2):795-807. Epub 2017 Jan 9.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Tage-Hansens Gade 2, 8000, Aarhus, Denmark.

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http://dx.doi.org/10.1007/s00394-016-1369-8DOI Listing
March 2018

Glucagon-Like Peptide-1 Inhibits Prandial Gastrointestinal Motility Through Myenteric Neuronal Mechanisms in Humans.

Authors:
Md Abdul Halim Marie Degerblad Magnus Sundbom Urban Karlbom Jens Juul Holst Dominic-Luc Webb Per M Hellström

J Clin Endocrinol Metab 2018 02;103(2):575-585

Department of Medical Sciences, Gastroenterology Unit, Uppsala University, Uppsala, Sweden.

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https://academic.oup.com/jcem/article/103/2/575/4644818
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http://dx.doi.org/10.1210/jc.2017-02006DOI Listing
February 2018

Glucose-dependent insulinotropic polypeptide (GIP) receptor antagonists as anti-diabetic agents.

Authors:
Lærke Smidt Gasbjerg Maria Buur Nordskov Gabe Bolette Hartmann Mikkel Bring Christensen Filip Krag Knop Jens Juul Holst Mette Marie Rosenkilde

Peptides 2018 02;100:173-181

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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https://linkinghub.elsevier.com/retrieve/pii/S01969781173036
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http://dx.doi.org/10.1016/j.peptides.2017.11.021DOI Listing
February 2018

Erratum to semaglutide seems to be more effective the other GLP-1Ras.

Authors:
Jens Juul Holst Sten Madsbad

Ann Transl Med 2018 Feb;6(3):74

Department of Endocrinology, Copenhagen University Hospital Hvidovre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.21037/atm.2018.01.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879530PMC
February 2018

Effect of Liraglutide Treatment on Jejunostomy Output in Patients With Short Bowel Syndrome: An Open-Label Pilot Study.

Authors:
Mark Hvistendahl Christopher Filtenborg Brandt Siri Tribler Rahim Mohammad Naimi Bolette Hartmann Jens Juul Holst Jens Frederik Rehfeld Mads Hornum Jens Rikardt Andersen Birthe Merete Henriksen Per Brøbech Mortensen Palle Bekker Jeppesen

JPEN J Parenter Enteral Nutr 2018 Jan 11;42(1):112-121. Epub 2017 Dec 11.

Department of Medical Gastroenterology CA-2121, Rigshospitalet, Copenhagen, Denmark.

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http://doi.wiley.com/10.1177/0148607116672265
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http://dx.doi.org/10.1177/0148607116672265DOI Listing
January 2018

Comparing olive oil and C4-dietary oil, a prodrug for the GPR119 agonist, 2-oleoyl glycerol, less energy intake of the latter is needed to stimulate incretin hormone secretion in overweight subjects with type 2 diabetes.

Authors:
Mette Johannsen Mandøe Katrine Bagge Hansen Johanne Agerlin Windeløv Filip Krag Knop Jens Frederik Rehfeld Mette Marie Rosenkilde Jens Juul Holst Harald Severin Hansen

Nutr Diabetes 2018 01 12;8(1). Epub 2018 Jan 12.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1038/s41387-017-0011-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199285PMC
January 2018

Pre-Meal Effect of Whey Proteins on Metabolic Parameters in Subjects with and without Type 2 Diabetes: A Randomized, Crossover Trial.

Authors:
Ann Bjørnshave Jens Juul Holst Kjeld Hermansen

Nutrients 2018 Jan 25;10(2). Epub 2018 Jan 25.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, DK-8000 Aarhus, Denmark.

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http://dx.doi.org/10.3390/nu10020122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852698PMC
January 2018

Comparison of Glycomacropeptide with Phenylalanine Free-Synthetic Amino Acids in Test Meals to PKU Patients: No Significant Differences in Biomarkers, Including Plasma Phe Levels.

Authors:
Kirsten K Ahring Allan M Lund Erik Jensen Thomas G Jensen Karen Brøndum-Nielsen Michael Pedersen Allan Bardow Jens Juul Holst Jens F Rehfeld Lisbeth B Møller

J Nutr Metab 2018 8;2018:6352919. Epub 2018 Jan 8.

Department of Clinical Genetics, Applied Human Molecular Genetics, Kennedy Center, Rigshospitalet, Denmark.

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http://dx.doi.org/10.1155/2018/6352919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817308PMC
January 2018

Discovery, characterization, and clinical development of the glucagon-like peptides.

Authors:
Daniel J Drucker Joel F Habener Jens Juul Holst

J Clin Invest 2017 Dec 1;127(12):4217-4227. Epub 2017 Dec 1.

Novo Nordisk Foundation Center for Basic Metabolic Research, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1172/JCI97233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707151PMC
December 2017

Glucagon-like peptide-1 acutely affects renal blood flow and urinary flow rate in spontaneously hypertensive rats despite significantly reduced renal expression of GLP-1 receptors.

Authors:
Jonas Ronn Elisa P Jensen Nicolai J Wewer Albrechtsen Jens Juul Holst Charlotte M Sorensen

Physiol Rep 2017 Dec;5(23)

Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.14814/phy2.13503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727271PMC
December 2017

Semaglutide seems to be more effective the other GLP-1Ras.

Authors:
Jens Juul Holst Sten Madsbad

Ann Transl Med 2017 Dec;5(24):505

Department of Endocrinology, Copenhagen University Hospital Hvidovre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.21037/atm.2017.11.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750268PMC
December 2017

Major rapid weight loss induces changes in cardiac repolarization.

Authors:
Esben Vedel-Larsen Eva Winning Iepsen Julie Lundgren Claus Graff Johannes J Struijk Torben Hansen Jens Juul Holst Sten Madsbad Signe Torekov Jørgen K Kanters

J Electrocardiol 2016 May-Jun;49(3):467-72. Epub 2016 Feb 10.

Laboratory of Experimental Cardiology, Departtment of Biomedical Sciences, University of Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jelectrocard.2016.02.005DOI Listing
November 2017

Cross-Validation of a Glucose-Insulin-Glucagon Pharmacodynamics Model for Simulation Using Data From Patients With Type 1 Diabetes.

Authors:
Sabrina Lyngbye Wendt Ajenthen Ranjan Jan Kloppenborg Møller Signe Schmidt Carsten Boye Knudsen Jens Juul Holst Sten Madsbad Henrik Madsen Kirsten Nørgaard John Bagterp Jørgensen

J Diabetes Sci Technol 2017 Nov 1;11(6):1101-1111. Epub 2017 Feb 1.

2 Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kgs. Lyngby, Denmark.

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http://dx.doi.org/10.1177/1932296817693254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951032PMC
November 2017

Genetic determinants of circulating GIP and GLP-1 concentrations.

Authors:
Peter Almgren Andreas Lindqvist Ulrika Krus Liisa Hakaste Emilia Ottosson-Laakso Olof Asplund Emily Sonestedt Rashmi B Prasad Esa Laurila Marju Orho-Melander Olle Melander Tiinamaija Tuomi Jens Juul Holst Peter M Nilsson Nils Wierup Leif Groop Emma Ahlqvist

JCI Insight 2017 11 2;2(21). Epub 2017 Nov 2.

Lund University Diabetes Centre, Department of Clinical Sciences, Malmö, Lund University, Skåne University Hospital, Malmö, Sweden.

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http://dx.doi.org/10.1172/jci.insight.93306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963138PMC
November 2017

Short-term effects of a low carbohydrate diet on glycaemic variables and cardiovascular risk markers in patients with type 1 diabetes: A randomized open-label crossover trial.

Authors:
Ajenthen Ranjan Signe Schmidt Camilla Damm-Frydenberg Jens Juul Holst Sten Madsbad Kirsten Nørgaard

Diabetes Obes Metab 2017 10 10;19(10):1479-1484. Epub 2017 Jul 10.

Department of Endocrinology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

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http://dx.doi.org/10.1111/dom.12953DOI Listing
October 2017

DPP4 gene variation affects GLP-1 secretion, insulin secretion, and glucose tolerance in humans with high body adiposity.

Authors:
Anja Böhm Robert Wagner Fausto Machicao Jens Juul Holst Baptist Gallwitz Norbert Stefan Andreas Fritsche Hans-Ulrich Häring Harald Staiger

PLoS One 2017 27;12(7):e0181880. Epub 2017 Jul 27.

German Center for Diabetes Research (DZD), Tübingen, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181880PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531535PMC
October 2017

The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor.

Authors:
Meena Asmar Ali Asmar Lene Simonsen Lærke Smidt Gasbjerg Alexander Hovard Sparre-Ulrich Mette Marie Rosenkilde Bolette Hartmann Flemming Dela Jens Juul Holst Jens Bülow

Diabetes 2017 09 30;66(9):2363-2371. Epub 2017 Jun 30.

Department of Clinical Physiology and Nuclear Medicine, Bispebjerg University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.2337/db17-0480DOI Listing
September 2017

The Gut: A Key to the Pathogenesis of Type 2 Diabetes?

Authors:
Jens Juul Holst Jens Pedersen Nicolai Jacob Wewer Albrechtsen Filip Krag Knop

Metab Syndr Relat Disord 2017 08 12;15(6):259-262. Epub 2017 Jun 12.

2 Center for Diabetes Research, Gentofte Hospital, University of Copenhagen , Copenhagen, Denmark .

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http://dx.doi.org/10.1089/met.2017.0015DOI Listing
August 2017

Effect of oral contraceptives and/or metformin on GLP-1 secretion and reactive hypoglycaemia in polycystic ovary syndrome.

Authors:
Dorte Glintborg Hanne Mumm Jens Juul Holst Marianne Andersen

Endocr Connect 2017 May 21;6(4):267-277. Epub 2017 Apr 21.

Department of Endocrinology and MetabolismOdense University Hospital, Odense C, Denmark.

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http://dx.doi.org/10.1530/EC-17-0034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457494PMC
May 2017

Differential impact of glucose administered intravenously or orally on bone turnover markers in healthy male subjects.

Authors:
Sidse Westberg-Rasmussen Jakob Starup-Linde Kjeld Hermansen Jens Juul Holst Bolette Hartmann Peter Vestergaard Søren Gregersen

Bone 2017 04 23;97:261-266. Epub 2017 Jan 23.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1016/j.bone.2017.01.027DOI Listing
April 2017

Insulin and Glucagon: Partners for Life.

Authors:
Jens Juul Holst William Holland Jesper Gromada Young Lee Roger H Unger Hai Yan Kyle W Sloop Timothy J Kieffer Nicolas Damond Pedro L Herrera

Endocrinology 2017 04;158(4):696-701

Department of Genetic Medicine & Development, Faculty of Medicine, University of Geneva, CH-1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1210/en.2016-1748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061217PMC
April 2017

Preserved glucagon-like peptide-1 responses to oral glucose, but reduced incretin effect, insulin secretion and sensitivity in young Asians with type 2 diabetes mellitus.

Authors:
Toh Peng Yeow Giovanni Pacini Andrea Tura Chee Peng Hor Shueh Lin Lim Florence Hui Sieng Tan Chin Voon Tong Janet Yeow Hua Hong Fuziah Md Zain Jens Juul Holst Wan Nazaimoon Wan Mohamud

BMJ Open Diabetes Res Care 2017 10;5(1):e000352. Epub 2017 Mar 10.

Department of Cardiovascular , Diabetes and Nutrition Research Centre, Institute for Medical Research , Kuala Lumpur , Malaysia.

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http://dx.doi.org/10.1136/bmjdrc-2016-000352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353273PMC
March 2017

Hypoglycemia-Associated EEG Changes Following Antecedent Hypoglycemia in Type 1 Diabetes Mellitus.

Authors:
Anne-Sophie Sejling Troels W Kjaer Ulrik Pedersen-Bjergaard Line S Remvig Christian S Frandsen Linda Hilsted Jens Faber Jens Juul Holst Lise Tarnow Jakob Skadkær Møller Martin N Nielsen Birger Thorsteinsson Claus B Juhl

Diabetes Technol Ther 2017 02;19(2):85-90

1 Faculty of Health, University of Southern Denmark , Odense, Denmark .

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http://dx.doi.org/10.1089/dia.2016.0331DOI Listing
February 2017

Acute effects of glucagon-like peptide-1, GLP-1, and exenatide on mesenteric blood flow, cardiovascular parameters, and biomarkers in healthy volunteers.

Authors:
Lasse Bremholm Ulrik B Andersen Mads Hornum Linda Hilsted Simon Veedfald Bolette Hartmann Jens Juul Holst

Physiol Rep 2017 Feb;5(4)

Department of Biomedical Sciences & NNF Center for Basic Metabolic Research, The Panum Institute, University of Copenhagen, Copenhagen, Denmark

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http://dx.doi.org/10.14814/phy2.13102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328764PMC
February 2017

Low-Carbohydrate Diet Impairs the Effect of Glucagon in the Treatment of Insulin-Induced Mild Hypoglycemia: A Randomized Crossover Study.

Authors:
Ajenthen Ranjan Signe Schmidt Camilla Damm-Frydenberg Isabelle Steineck Trine Ryberg Clausen Jens Juul Holst Sten Madsbad Kirsten Nørgaard

Diabetes Care 2017 Jan 21;40(1):132-135. Epub 2016 Oct 21.

Department of Endocrinology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

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http://dx.doi.org/10.2337/dc16-1472DOI Listing
January 2017

Peptide YY3-36 and glucagon-like peptide-1 in functional dyspepsia. Secretion and role in symptom generation.

Authors:
Anne-Barbara Witte Linda Hilsted Jens Juul Holst Peter Thelin Schmidt

Scand J Gastroenterol 2016 26;51(4):400-9. Epub 2015 Oct 26.

a Center for Digestive Diseases, Karolinska University Hospital, Karolinska Institute , Stockholm , Sweden ;

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http://dx.doi.org/10.3109/00365521.2015.1101780DOI Listing
November 2016

Insulin Resistance Is Accompanied by Increased Fasting Glucagon and Delayed Glucagon Suppression in Individuals With Normal and Impaired Glucose Regulation.

Authors:
Kristine Færch Dorte Vistisen Giovanni Pacini Signe S Torekov Nanna B Johansen Daniel R Witte Anna Jonsson Oluf Pedersen Torben Hansen Torsten Lauritzen Marit E Jørgensen Bo Ahrén Jens Juul Holst

Diabetes 2016 Nov 8;65(11):3473-3481. Epub 2016 Aug 8.

Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.2337/db16-0240DOI Listing
November 2016

Liraglutide for treating type 1 diabetes.

Authors:
Thomas Fremming Dejgaard Christian Seerup Frandsen Jens Juul Holst Sten Madsbad

Expert Opin Biol Ther 2016 ;16(4):579-90

a Department of Endocrinology, Hvidovre Hospital , University of Copenhagen , Hvidovre , Denmark.

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http://dx.doi.org/10.1517/14712598.2016.1160050DOI Listing
October 2016

Regulation of Pancreatic α-Cell Function and Proliferation by Bone Morphogenetic Protein 4 (BMP4) In Vitro.

Authors:
Sofie Sylvest Nielsen Gitte Lund Christensen Jens Juul Holst Nils Billestrup

Endocrinology 2016 Oct 1;157(10):3809-3820. Epub 2016 Aug 1.

Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1210/en.2016-1163DOI Listing
October 2016

Insulin Plays a Permissive Role for the Vasoactive Effect of GIP Regulating Adipose Tissue Metabolism in Humans.

Authors:
Meena Asmar Lene Simonsen Ali Asmar Jens Juul Holst Flemming Dela Jens Bülow

J Clin Endocrinol Metab 2016 08 3;101(8):3155-62. Epub 2016 Jun 3.

Department of Clinical Physiology/Nuclear Medicine (M.A., L.S., A.A., J.B.), Bispebjerg University Hospital, Copenhagen, Denmark; The Novo Nordisk Foundation Center for Basic Metabolic Research (J.J.H.), University of Copenhagen, Copenhagen, Denmark; Department of Biomedical Sciences (J.J.H., J.B.), University of Copenhagen, Copenhagen, Denmark; Xlab, Center for Healthy Ageing (F.D.), University of Copenhagen, Denmark; Department of Geriatrics (F.D.), Bispebjerg University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1210/jc.2016-1933DOI Listing
August 2016

Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells.

Authors:
Søren Fisker Schmidt Jesper Grud Skat Madsen Kari Østerli Frafjord Lars la Cour Poulsen Sofia Salö Michael Boergesen Anne Loft Bjørk Ditlev Larsen Maria Stahl Madsen Jens Juul Holst Pierre Maechler Louise Torp Dalgaard Susanne Mandrup

Cell Rep 2016 08 18;16(9):2359-72. Epub 2016 Aug 18.

Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.07.063DOI Listing
August 2016

The insulinotropic effect of exogenous glucagon-like peptide-1 is not affected by acute vagotomy in anaesthetized pigs.

Authors:
Simon Veedfald Marie Hansen Louise Wulff Christensen Sara Agnete Hjort Larsen Karina Rahr Hjøllund Astrid Plamboeck Bolette Hartmann Carolyn Fiona Deacon Jens Juul Holst

Exp Physiol 2016 07;101(7):895-912

Department of Biomedical Sciences (endocrinology section) and NNF Center for Basic Metabolic Research (translational metabolic physiology section), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1113/EP085692DOI Listing
July 2016

Mechanisms of surgical control of type 2 diabetes: GLP-1 is key factor.

Authors:
Jens Juul Holst Sten Madsbad

Surg Obes Relat Dis 2016 Jul 3;12(6):1236-42. Epub 2016 Mar 3.

Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.soard.2016.02.033DOI Listing
July 2016

Minor Contribution of Endogenous GLP-1 and GLP-2 to Postprandial Lipemia in Obese Men.

Authors:
Niina Matikainen Elias Björnson Sanni Söderlund Christofer Borén Björn Eliasson Kirsi H Pietiläinen Leonie H Bogl Antti Hakkarainen Nina Lundbom Angela Rivellese Gabriele Riccardi Jean-Pierre Després Natalie Alméras Jens Juul Holst Carolyn F Deacon Jan Borén Marja-Riitta Taskinen

PLoS One 2016 11;11(1):e0145890. Epub 2016 Jan 11.

Research programs Unit, Diabetes and Obesity, University of Helsinki and Heart and Lung Center, Helsinki University Hospital, Helsinki, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145890PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709062PMC
June 2016

Roles of the Gut in Glucose Homeostasis.

Authors:
Jens Juul Holst Fiona Gribble Michael Horowitz Chris K Rayner

Diabetes Care 2016 Jun;39(6):884-92

Discipline of Medicine, University of Adelaide and Royal Adelaide Hospital, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.2337/dc16-0351DOI Listing
June 2016

In vivo and in vitro degradation of peptide YY3-36 to inactive peptide YY3-34 in humans.

Authors:
Signe Toräng Kirstine Nyvold Bojsen-Møller Maria Saur Svane Bolette Hartmann Mette Marie Rosenkilde Sten Madsbad Jens Juul Holst

Am J Physiol Regul Integr Comp Physiol 2016 05 27;310(9):R866-74. Epub 2016 Jan 27.

Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; NNF Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark;

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http://dx.doi.org/10.1152/ajpregu.00394.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000776PMC
May 2016

Cholecystokinin-Induced Gallbladder Emptying and Metformin Elicit Additive Glucagon-Like Peptide-1 Responses.

Authors:
Ulrich Rohde David Peick Sonne Mikkel Christensen Morten Hansen Andreas Brønden Signe Toräng Jens Frederik Rehfeld Jens Juul Holst Tina Vilsbøll Filip Krag Knop

J Clin Endocrinol Metab 2016 05 22;101(5):2076-83. Epub 2016 Mar 22.

Center for Diabetes Research (U.R., D.P.S., M.C., M.H., A.B., T.V., F.K.K.), Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research and Department of Biomedical Sciences (U.R., M.H., S.T., J.J.H., F.K.K.), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Department of Clinical Pharmacology (M.C.), Bispebjerg Hospital, University of Copenhagen, 2400 Copenhagen, Denmark; and Department of Clinical Biochemistry (J.F.R.), Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1210/jc.2016-1133DOI Listing
May 2016

COMPARISON OF THE LONG-TERM EFFECTS OF LIRAGLUTIDE AND GLIMEPIRIDE MONOTHERAPY ON BONE MINERAL DENSITY IN PATIENTS WITH TYPE 2 DIABETES.

Authors:
Matthew P Gilbert Michel Marre Jens Juul Holst Alan Garber Florian M M Baeres Henrik Thomsen Richard E Pratley

Endocr Pract 2016 Apr 17;22(4):406-11. Epub 2015 Nov 17.

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http://dx.doi.org/10.4158/EP15758.ORDOI Listing
April 2016

Atrial Natriuretic Peptide in the High Normal Range Is Associated With Lower Prevalence of Insulin Resistance.

Authors:
Amra Jujić Peter M Nilsson Margaretha Persson Jens Juul Holst Signe Sørensen Torekov Valeriya Lyssenko Leif Groop Olle Melander Martin Magnusson

J Clin Endocrinol Metab 2016 Apr 27;101(4):1372-80. Epub 2016 Jan 27.

Departments of Cardiology (A.J., M.M.), Internal Medicine (O.M.), and Clinical Sciences (A.J., P.M.N., M.P., L.G., O.M., M.M.), Skåne University Hospital, SE-205 02 Malmö, Sweden; Department of Clinical Sciences (V.L.), Diabetes and Endocrinology Unit, Lund University Diabetes Center, Lund University, SE-200 41 Malmö, Sweden; Department of Biomedical Sciences and NNF Center for Basal Metabolic Research (J.J.H., S.S.T.), The Panum Institute, DK-2200 Copenhagen, Denmark; and Steno Diabetes Center A/S (V.L.), DK-2820 Gentofte, Denmark.

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http://dx.doi.org/10.1210/jc.2015-3518DOI Listing
April 2016

Peptide production and secretion in GLUTag, NCI-H716, and STC-1 cells: a comparison to native L-cells.

Authors:
Rune Ehrenreich Kuhre Nicolai Jacob Wewer Albrechtsen Carolyn Fiona Deacon Emilie Balk-Møller Jens Frederik Rehfeld Frank Reimann Fiona Mary Gribble Jens Juul Holst

J Mol Endocrinol 2016 04 27;56(3):201-11. Epub 2016 Jan 27.

Department of Biomedical Sciences and NNF Center for Basic Metabolic Researchthe Panum Institute, University of Copenhagen, Copenhagen, Denmark

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http://dx.doi.org/10.1530/JME-15-0293DOI Listing
April 2016

Rapid gut growth but persistent delay in digestive function in the postnatal period of preterm pigs.

Authors:
Carl Frederik Hansen Thomas Thymann Anders Daniel Andersen Jens Juul Holst Bolette Hartmann Linda Hilsted Louise Langhorn Jacob Jelsing Per Torp Sangild

Am J Physiol Gastrointest Liver Physiol 2016 04 28;310(8):G550-60. Epub 2016 Jan 28.

Comparative Pediatrics and Nutrition, University of Copenhagen, Copenhagen, Denmark; Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Denmark.

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http://dx.doi.org/10.1152/ajpgi.00221.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836131PMC
April 2016

Searching for the physiological role of glucose-dependent insulinotropic polypeptide.

Authors:
Jens Juul Holst Johanne Agerlin Windeløv Geke Aline Boer Jens Pedersen Berit Svendsen Mikkel Christensen Signe Torekov Meena Asmar Bolette Hartmann Anne Nissen

J Diabetes Investig 2016 Apr 18;7 Suppl 1:8-12. Epub 2016 Apr 18.

The NNF Center for Basic Metabolic ResearchCopnehagenDenmark; Department of Biomedical SciencesThe Panum InstituteUniversity of CopenhagenCopnehagenDenmark.

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http://dx.doi.org/10.1111/jdi.12488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854498PMC
April 2016

Efficacy and safety of liraglutide for overweight adult patients with type 1 diabetes and insufficient glycaemic control (Lira-1): a randomised, double-blind, placebo-controlled trial.

Authors:
Thomas Fremming Dejgaard Christian Seerup Frandsen Tanja Stenbæk Hansen Thomas Almdal Søren Urhammer Ulrik Pedersen-Bjergaard Tonny Jensen Andreas Kryger Jensen Jens Juul Holst Lise Tarnow Filip Krag Knop Sten Madsbad Henrik Ullits Andersen

Lancet Diabetes Endocrinol 2016 Mar 3;4(3):221-232. Epub 2015 Dec 3.

Steno Diabetes Center, Gentofte, Denmark.

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http://dx.doi.org/10.1016/S2213-8587(15)00436-2DOI Listing
March 2016

Glucose-Dependent Insulinotropic Polypeptide Is Associated With Lower Low-Density Lipoprotein But Unhealthy Fat Distribution, Independent of Insulin: The ADDITION-PRO Study.

Authors:
Cathrine Laustrup Møller Dorte Vistisen Kristine Færch Nanna Borup Johansen Daniel R Witte Anna Jonsson Oluf Pedersen Torben Hansen Torsten Lauritzen Marit E Jørgensen Signe S Torekov Jens Juul Holst

J Clin Endocrinol Metab 2016 Feb 27;101(2):485-93. Epub 2015 Oct 27.

Steno Diabetes Center (C.L.M., D.V., K.F., N.B.J., M.E.J.), 2820 Gentofte, Denmark; The Danish Diabetes Academy (N.B.J., D.R.W.), 5000 Odense, Denmark; Department of Public Health, Section for General Practice (D.R.W., T.L.), Aarhus University, 8000 Aarhus, Denmark; NNF Center for Basic Metabolic Research (A.J., O.P., T.H., S.S.T., J.J.H.), University of Copenhagen, 2200 Copenhagen, Denmark; and Department of Biomedical Sciences (S.S.T., J.J.H.), Public Health, University of Copenhagen, 1014 Copenhagen, Denmark.

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http://dx.doi.org/10.1210/jc.2015-3133DOI Listing
February 2016

Do glucagonomas always produce glucagon?

Authors:
Nicolai Jacob Wewer Albrechtsen Benjamin G Challis Ivan Damjanov Jens Juul Holst

Bosn J Basic Med Sci 2016 Feb 1;16(1):1-7. Epub 2016 Feb 1.

1: Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark 2: Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

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http://dx.doi.org/10.17305/bjbms.2015.794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765933PMC
February 2016

Resistant starch and protein intake enhances fat oxidation and feelings of fullness in lean and overweight/obese women.

Authors:
Christopher L Gentile Emery Ward Jens Juul Holst Arne Astrup Michael J Ormsbee Scott Connelly Paul J Arciero

Nutr J 2015 Oct 29;14:113. Epub 2015 Oct 29.

Human Nutrition and Metabolism Laboratory, Department of Health and Exercise Sciences, Skidmore College, 815 North Broadway, Saratoga Springs, NY, 12866, USA.

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http://nutritionj.biomedcentral.com/articles/10.1186/s12937-
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http://dx.doi.org/10.1186/s12937-015-0104-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627411PMC
October 2015