Jens Juul Holst

Jens Juul Holst

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Jens Juul Holst

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Incretin therapy for diabetes mellitus type 2.

Authors:
Jens Juul Holst

Curr Opin Endocrinol Diabetes Obes 2019 Dec 4. Epub 2019 Dec 4.

NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, The Panum Institute, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen N, Denmark.

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http://dx.doi.org/10.1097/MED.0000000000000516DOI Listing
December 2019

A Low Dose of Pasireotide Prevents Hypoglycemia in Roux-en-Y Gastric Bypass-Operated Individuals.

Obes Surg 2019 Nov 10. Epub 2019 Nov 10.

Department of Medicine, Amager Hospital, Amager, Denmark.

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http://dx.doi.org/10.1007/s11695-019-04248-xDOI Listing
November 2019

Correction to: Effects of glucagon-like peptide 1 analogs on alcohol intake in alcohol-preferring vervet monkeys.

Psychopharmacology (Berl) 2019 Nov 25. Epub 2019 Nov 25.

Laboratory of Neuropsychiatry, Psychiatric Centre Copenhagen and University Hospital of Copenhagen, Edel Sauntes Allé 10, DK-2100, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s00213-019-05374-1DOI Listing
November 2019

Ghrelin does not directly stimulate secretion of glucagon-like peptide-1.

J Clin Endocrinol Metab 2019 Oct 14. Epub 2019 Oct 14.

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1210/clinem/dgz046DOI Listing
October 2019

A Pilot Study Showing Acute Inhibitory Effect of GLP-1 on the Bone Resorption Marker CTX in Humans.

JBMR Plus 2019 Oct 23;3(10):e10209. Epub 2019 Aug 23.

Department of Biomedical Sciences The Panum Institute, University of Copenhagen Copenhagen Denmark.

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http://dx.doi.org/10.1002/jbm4.10209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820456PMC
October 2019

Postprandial hypoglycaemia after Roux-en-Y gastric bypass and the effects of acarbose, sitagliptin, verapamil, liraglutide and pasireotide.

Diabetes Obes Metab 2019 Sep 24;21(9):2142-2151. Epub 2019 Jun 24.

Clinical Department, Steno Diabetes Center, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/dom.13796DOI Listing
September 2019

The imprinted gene Delta like non-canonical notch ligand 1 (Dlk1) associates with obesity and triggers insulin resistance through inhibition of skeletal muscle glucose uptake.

EBioMedicine 2019 Aug 3;46:368-380. Epub 2019 Aug 3.

Laboratory of Molecular and Cellular Cardiology, Dep. of Clinical Biochemistry and Pharmacology, Odense University Hospital, Denmark; Danish Center for Regenerative Medicine (danishcrm.com), Odense University Hospital, Denmark; Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; Clinical Institute, University of Southern Denmark, Odense, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.07.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711890PMC
August 2019

Short-chain fatty acids and regulation of pancreatic endocrine secretion in mice.

Islets 2019 30;11(5):103-111. Epub 2019 Aug 30.

The Novo Nordisk Foundation Center for Basic Metabolic Research, Translational Metabolic Physiology, Faculty of Health Sciences, University of Copenhagen , Copenhagen , Denmark.

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http://dx.doi.org/10.1080/19382014.2019.1587976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773373PMC
August 2019

Instrumentalization of Eating Improves Weight Loss Maintenance in Obesity.

Obes Facts 2017 6;10(6):633-647. Epub 2017 Dec 6.

Institute of Food and Resource Economics, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1159/000481138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836264PMC
July 2019

Separate and Combined Effects of GIP and GLP-1 Infusions on Bone Metabolism in Overweight Men Without Diabetes.

J Clin Endocrinol Metab 2019 Jul;104(7):2953-2960

Clinical Metabolic Physiology, Steno Diabetes Center Copenhagen, Gentofte Hospital, Hellerup, Denmark.

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http://dx.doi.org/10.1210/jc.2019-00008DOI Listing
July 2019

The incretin system in healthy humans: The role of GIP and GLP-1.

Authors:
Jens Juul Holst

Metabolism 2019 Jul 25;96:46-55. Epub 2019 Apr 25.

The NNF center for Basic Metabolic Research and Department of Biomedical Sciences, the Panum Institute, University of Copenhagen, DK-2200, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2019.04.014DOI Listing
July 2019

Which to choose, an oral or an injectable glucagon-like peptide-1 receptor agonist?

Authors:
Jens Juul Holst

Lancet 2019 07 8;394(10192):4-6. Epub 2019 Jun 8.

Department of Biomedical Sciences and NNF Center for Basic Metabolic Research, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(19)31350-9DOI Listing
July 2019

Pros and cons of Roux en-Y gastric bypass surgery in obese patients with type 2 diabetes.

Expert Rev Endocrinol Metab 2019 07 19;14(4):243-257. Epub 2019 Jun 19.

a Department of Endocrinology , Copenhagen University Hospital Hvidovre , Hvidovre , Denmark.

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http://dx.doi.org/10.1080/17446651.2019.1628639DOI Listing
July 2019

Glucagon-Like Peptide-1 Is a Marker of Systemic Inflammation in Patients Treated with High-Dose Chemotherapy and Autologous Stem Cell Transplantation.

Biol Blood Marrow Transplant 2019 06 5;25(6):1085-1091. Epub 2019 Feb 5.

Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark; Institute for Inflammation Research, University Hospital Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.bbmt.2019.01.036DOI Listing
June 2019

The diurnal variation of bone formation is attenuated in adult patients with type 2 diabetes.

Eur J Endocrinol 2019 Jun 1. Epub 2019 Jun 1.

B Langdahl, Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus N, Denmark.

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http://dx.doi.org/10.1530/EJE-19-0309DOI Listing
June 2019

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents.

Am J Physiol Gastrointest Liver Physiol 2019 May 15;316(5):G574-G584. Epub 2019 Feb 15.

Novo Nordic Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark.

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https://www.physiology.org/doi/10.1152/ajpgi.00010.2019
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http://dx.doi.org/10.1152/ajpgi.00010.2019DOI Listing
May 2019

Effect of liraglutide on body weight and microvascular function in non-diabetic overweight women with coronary microvascular dysfunction.

Int J Cardiol 2019 05 2;283:28-34. Epub 2019 Jan 2.

Department of Cardiology, Bispebjerg University Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.ijcard.2018.12.005DOI Listing
May 2019

GIP-induced vasodilation in human adipose tissue involves capillary recruitment.

Endocr Connect 2019 May 1. Epub 2019 May 1.

J Bülow, Department of Clinical Physiology/Nuclear Medicine, Bispebjerg Hospital, Kobenhavn, Denmark.

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http://dx.doi.org/10.1530/EC-19-0144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590203PMC
May 2019

Effects of active commuting and leisure-time exercise on appetite in individuals with overweight and obesity.

J Appl Physiol (1985) 2019 Apr 3;126(4):941-951. Epub 2019 Jan 3.

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark.

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https://www.physiology.org/doi/10.1152/japplphysiol.00239.20
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http://dx.doi.org/10.1152/japplphysiol.00239.2018DOI Listing
April 2019

Peptone-mediated glucagon-like peptide-1 secretion depends on intestinal absorption and activation of basolaterally located Calcium-Sensing Receptors.

Physiol Rep 2019 04;7(8):e14056

Department of Biomedical Sciences, NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.14814/phy2.14056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482282PMC
April 2019

From the Incretin Concept and the Discovery of GLP-1 to Today's Diabetes Therapy.

Authors:
Jens Juul Holst

Front Endocrinol (Lausanne) 2019 26;10:260. Epub 2019 Apr 26.

Department of Biomedical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.3389/fendo.2019.00260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497767PMC
April 2019

A pre-meal of whey proteins induces differential effects on glucose and lipid metabolism in subjects with the metabolic syndrome: a randomised cross-over trial.

Eur J Nutr 2019 Mar 6;58(2):755-764. Epub 2018 Apr 6.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Tage-Hansens Gade 2, 8000, Aarhus C, Denmark.

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http://dx.doi.org/10.1007/s00394-018-1684-3DOI Listing
March 2019

Neuromedin U Does Not Act as a Decretin in Rats.

Cell Metab 2019 03 15;29(3):719-726.e5. Epub 2018 Nov 15.

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Panum Institute, Blegdamsvej 3B, 12.2, 2200 Copenhagen N, Denmark; NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.10.008DOI Listing
March 2019

The effect of DPP-4-protected GLP-1 (7-36) on coronary microvascular function in obese adults.

Int J Cardiol Heart Vasc 2019 Mar 29;22:139-144. Epub 2019 Jan 29.

Department of Endocrinology, Bispebjerg University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.ijcha.2019.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356020PMC
March 2019

Long-acting glucagon-like peptide-1 receptor agonist-status December 2018.

Authors:
Jens Juul Holst

Ann Transl Med 2019 Mar;7(5):83

Department of Biomedical Sciences and NNF center for Basic Metabolic Research, The Panum Institute, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.21037/atm.2019.01.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462657PMC
March 2019

Effects of glucagon-like peptide 1 analogs on alcohol intake in alcohol-preferring vervet monkeys.

Psychopharmacology (Berl) 2019 Feb 31;236(2):603-611. Epub 2018 Oct 31.

Laboratory of Neuropsychiatry, Psychiatric Centre Copenhagen and University Hospital of Copenhagen, Edel Sauntes Allé 10, DK-2100, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s00213-018-5089-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428196PMC
February 2019

Gut Hormones and Their Effect on Bone Metabolism. Potential Drug Therapies in Future Osteoporosis Treatment.

Front Endocrinol (Lausanne) 2019 26;10:75. Epub 2019 Feb 26.

Laboratory of Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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https://www.frontiersin.org/article/10.3389/fendo.2019.00075
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http://dx.doi.org/10.3389/fendo.2019.00075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399108PMC
February 2019

WITHDRAWN: Glucose-Dependent Insulinotropic Polypeptide Increases Blood Flow in Adipose Tissue of Humans by Recruiting Capillaries.

J Clin Endocrinol Metab 2019 01;104(1):W1-W9

Department of Clinical Physiology/Nuclear Medicine, Bispebjerg University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1210/jc.2018-00389DOI Listing
January 2019

Pre-meal and postprandial lipaemia in subjects with the metabolic syndrome: effects of timing and protein quality (randomised crossover trial).

Br J Nutr 2019 Jan 2:1-10. Epub 2019 Jan 2.

1Department of Endocrinology and Internal Medicine,Aarhus University Hospital,Aarhus,Denmark.

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http://dx.doi.org/10.1017/S0007114518003264DOI Listing
January 2019

Response to Letter to the Editor: "Hemodynamic Effects of Glucagon: A Literature Review".

J Clin Endocrinol Metab 2018 12;103(12):4480-4481

Department of Clinical Pharmacology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1210/jc.2018-01825DOI Listing
December 2018

Hepatic Insulin Clearance in Regulation of Systemic Insulin Concentrations-Role of Carbohydrate and Energy Availability.

Diabetes 2018 11;67(11):2129-2136

Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db18
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http://dx.doi.org/10.2337/db18-0539DOI Listing
November 2018

Insulin Secretion Depends on Intra-islet Glucagon Signaling.

Cell Rep 2018 10;25(5):1127-1134.e2

NovoNordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.celrep.2018.10.018DOI Listing
October 2018

The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon.

Am J Physiol Gastrointest Liver Physiol 2018 07 1;315(1):G53-G65. Epub 2018 Mar 1.

Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen , Copenhagen , Denmark.

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https://www.physiology.org/doi/10.1152/ajpgi.00346.2017
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http://dx.doi.org/10.1152/ajpgi.00346.2017DOI Listing
July 2018

Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control.

Cell Metab 2018 Jun 3;27(6):1201-1211.e3. Epub 2018 May 3.

The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183025
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http://dx.doi.org/10.1016/j.cmet.2018.04.008DOI Listing
June 2018

Non-insulin pharmacological therapies for treating type 1 diabetes.

Expert Opin Pharmacother 2018 06;19(9):947-960

c Department of Biomedical Sciences and NNF Center for Basic Metabolic Research , University of Copenhagen , Copenhagen , Denmark.

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http://dx.doi.org/10.1080/14656566.2018.1483339DOI Listing
June 2018

Hemodynamic Effects of Glucagon: A Literature Review.

J Clin Endocrinol Metab 2018 05;103(5):1804-1812

Department of Clinical Pharmacology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1210/jc.2018-00050DOI Listing
May 2018

Mechanisms in bariatric surgery: Gut hormones, diabetes resolution, and weight loss.

Surg Obes Relat Dis 2018 05 8;14(5):708-714. Epub 2018 Mar 8.

NNF Center for Basic Metabolic Research and Dept. Biomedical Sciences, the Panum Institute, University of Copenhagen, Copenhagen, Denmark; Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.soard.2018.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974695PMC
May 2018

Glucagon-Like Peptide-1 Inhibits Prandial Gastrointestinal Motility Through Myenteric Neuronal Mechanisms in Humans.

J Clin Endocrinol Metab 2018 02;103(2):575-585

Department of Medical Sciences, Gastroenterology Unit, Uppsala University, Uppsala, Sweden.

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https://academic.oup.com/jcem/article/103/2/575/4644818
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http://dx.doi.org/10.1210/jc.2017-02006DOI Listing
February 2018

Glucose-dependent insulinotropic polypeptide (GIP) receptor antagonists as anti-diabetic agents.

Peptides 2018 02;100:173-181

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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https://linkinghub.elsevier.com/retrieve/pii/S01969781173036
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http://dx.doi.org/10.1016/j.peptides.2017.11.021DOI Listing
February 2018

Erratum to semaglutide seems to be more effective the other GLP-1Ras.

Ann Transl Med 2018 Feb;6(3):74

Department of Endocrinology, Copenhagen University Hospital Hvidovre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.21037/atm.2018.01.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879530PMC
February 2018

Pre-Meal Effect of Whey Proteins on Metabolic Parameters in Subjects with and without Type 2 Diabetes: A Randomized, Crossover Trial.

Nutrients 2018 Jan 25;10(2). Epub 2018 Jan 25.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, DK-8000 Aarhus, Denmark.

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http://dx.doi.org/10.3390/nu10020122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852698PMC
January 2018

Discovery, characterization, and clinical development of the glucagon-like peptides.

J Clin Invest 2017 Dec 1;127(12):4217-4227. Epub 2017 Dec 1.

Novo Nordisk Foundation Center for Basic Metabolic Research, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1172/JCI97233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707151PMC
December 2017

Semaglutide seems to be more effective the other GLP-1Ras.

Ann Transl Med 2017 Dec;5(24):505

Department of Endocrinology, Copenhagen University Hospital Hvidovre, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.21037/atm.2017.11.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750268PMC
December 2017

Major rapid weight loss induces changes in cardiac repolarization.

J Electrocardiol 2016 May-Jun;49(3):467-72. Epub 2016 Feb 10.

Laboratory of Experimental Cardiology, Departtment of Biomedical Sciences, University of Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jelectrocard.2016.02.005DOI Listing
November 2017

Short-term effects of a low carbohydrate diet on glycaemic variables and cardiovascular risk markers in patients with type 1 diabetes: A randomized open-label crossover trial.

Diabetes Obes Metab 2017 10 10;19(10):1479-1484. Epub 2017 Jul 10.

Department of Endocrinology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

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http://dx.doi.org/10.1111/dom.12953DOI Listing
October 2017

The Gut: A Key to the Pathogenesis of Type 2 Diabetes?

Metab Syndr Relat Disord 2017 08 12;15(6):259-262. Epub 2017 Jun 12.

2 Center for Diabetes Research, Gentofte Hospital, University of Copenhagen , Copenhagen, Denmark .

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http://dx.doi.org/10.1089/met.2017.0015DOI Listing
August 2017

Effect of oral contraceptives and/or metformin on GLP-1 secretion and reactive hypoglycaemia in polycystic ovary syndrome.

Endocr Connect 2017 May 21;6(4):267-277. Epub 2017 Apr 21.

Department of Endocrinology and MetabolismOdense University Hospital, Odense C, Denmark.

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http://dx.doi.org/10.1530/EC-17-0034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457494PMC
May 2017

Differential impact of glucose administered intravenously or orally on bone turnover markers in healthy male subjects.

Bone 2017 04 23;97:261-266. Epub 2017 Jan 23.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1016/j.bone.2017.01.027DOI Listing
April 2017

Insulin and Glucagon: Partners for Life.

Endocrinology 2017 04;158(4):696-701

Department of Genetic Medicine & Development, Faculty of Medicine, University of Geneva, CH-1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1210/en.2016-1748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061217PMC
April 2017

Acute effects of glucagon-like peptide-1, GLP-1, and exenatide on mesenteric blood flow, cardiovascular parameters, and biomarkers in healthy volunteers.

Physiol Rep 2017 Feb;5(4)

Department of Biomedical Sciences & NNF Center for Basic Metabolic Research, The Panum Institute, University of Copenhagen, Copenhagen, Denmark

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http://dx.doi.org/10.14814/phy2.13102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328764PMC
February 2017

Low-Carbohydrate Diet Impairs the Effect of Glucagon in the Treatment of Insulin-Induced Mild Hypoglycemia: A Randomized Crossover Study.

Diabetes Care 2017 Jan 21;40(1):132-135. Epub 2016 Oct 21.

Department of Endocrinology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.

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http://dx.doi.org/10.2337/dc16-1472DOI Listing
January 2017

Peptide YY3-36 and glucagon-like peptide-1 in functional dyspepsia. Secretion and role in symptom generation.

Scand J Gastroenterol 2016 26;51(4):400-9. Epub 2015 Oct 26.

a Center for Digestive Diseases, Karolinska University Hospital, Karolinska Institute , Stockholm , Sweden ;

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http://dx.doi.org/10.3109/00365521.2015.1101780DOI Listing
November 2016

Liraglutide for treating type 1 diabetes.

Expert Opin Biol Ther 2016 ;16(4):579-90

a Department of Endocrinology, Hvidovre Hospital , University of Copenhagen , Hvidovre , Denmark.

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http://dx.doi.org/10.1517/14712598.2016.1160050DOI Listing
October 2016

Regulation of Pancreatic α-Cell Function and Proliferation by Bone Morphogenetic Protein 4 (BMP4) In Vitro.

Endocrinology 2016 Oct 1;157(10):3809-3820. Epub 2016 Aug 1.

Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1210/en.2016-1163DOI Listing
October 2016

Insulin Plays a Permissive Role for the Vasoactive Effect of GIP Regulating Adipose Tissue Metabolism in Humans.

J Clin Endocrinol Metab 2016 08 3;101(8):3155-62. Epub 2016 Jun 3.

Department of Clinical Physiology/Nuclear Medicine (M.A., L.S., A.A., J.B.), Bispebjerg University Hospital, Copenhagen, Denmark; The Novo Nordisk Foundation Center for Basic Metabolic Research (J.J.H.), University of Copenhagen, Copenhagen, Denmark; Department of Biomedical Sciences (J.J.H., J.B.), University of Copenhagen, Copenhagen, Denmark; Xlab, Center for Healthy Ageing (F.D.), University of Copenhagen, Denmark; Department of Geriatrics (F.D.), Bispebjerg University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1210/jc.2016-1933DOI Listing
August 2016

The insulinotropic effect of exogenous glucagon-like peptide-1 is not affected by acute vagotomy in anaesthetized pigs.

Exp Physiol 2016 07;101(7):895-912

Department of Biomedical Sciences (endocrinology section) and NNF Center for Basic Metabolic Research (translational metabolic physiology section), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1113/EP085692DOI Listing
July 2016

Mechanisms of surgical control of type 2 diabetes: GLP-1 is key factor.

Surg Obes Relat Dis 2016 Jul 3;12(6):1236-42. Epub 2016 Mar 3.

Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.soard.2016.02.033DOI Listing
July 2016

Roles of the Gut in Glucose Homeostasis.

Diabetes Care 2016 Jun;39(6):884-92

Discipline of Medicine, University of Adelaide and Royal Adelaide Hospital, Adelaide, South Australia, Australia.

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http://dx.doi.org/10.2337/dc16-0351DOI Listing
June 2016

In vivo and in vitro degradation of peptide YY3-36 to inactive peptide YY3-34 in humans.

Am J Physiol Regul Integr Comp Physiol 2016 05 27;310(9):R866-74. Epub 2016 Jan 27.

Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; NNF Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark;

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http://dx.doi.org/10.1152/ajpregu.00394.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000776PMC
May 2016

Cholecystokinin-Induced Gallbladder Emptying and Metformin Elicit Additive Glucagon-Like Peptide-1 Responses.

J Clin Endocrinol Metab 2016 05 22;101(5):2076-83. Epub 2016 Mar 22.

Center for Diabetes Research (U.R., D.P.S., M.C., M.H., A.B., T.V., F.K.K.), Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research and Department of Biomedical Sciences (U.R., M.H., S.T., J.J.H., F.K.K.), Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Department of Clinical Pharmacology (M.C.), Bispebjerg Hospital, University of Copenhagen, 2400 Copenhagen, Denmark; and Department of Clinical Biochemistry (J.F.R.), Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1210/jc.2016-1133DOI Listing
May 2016

Atrial Natriuretic Peptide in the High Normal Range Is Associated With Lower Prevalence of Insulin Resistance.

J Clin Endocrinol Metab 2016 Apr 27;101(4):1372-80. Epub 2016 Jan 27.

Departments of Cardiology (A.J., M.M.), Internal Medicine (O.M.), and Clinical Sciences (A.J., P.M.N., M.P., L.G., O.M., M.M.), Skåne University Hospital, SE-205 02 Malmö, Sweden; Department of Clinical Sciences (V.L.), Diabetes and Endocrinology Unit, Lund University Diabetes Center, Lund University, SE-200 41 Malmö, Sweden; Department of Biomedical Sciences and NNF Center for Basal Metabolic Research (J.J.H., S.S.T.), The Panum Institute, DK-2200 Copenhagen, Denmark; and Steno Diabetes Center A/S (V.L.), DK-2820 Gentofte, Denmark.

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http://dx.doi.org/10.1210/jc.2015-3518DOI Listing
April 2016

Peptide production and secretion in GLUTag, NCI-H716, and STC-1 cells: a comparison to native L-cells.

J Mol Endocrinol 2016 04 27;56(3):201-11. Epub 2016 Jan 27.

Department of Biomedical Sciences and NNF Center for Basic Metabolic Researchthe Panum Institute, University of Copenhagen, Copenhagen, Denmark

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http://dx.doi.org/10.1530/JME-15-0293DOI Listing
April 2016

Rapid gut growth but persistent delay in digestive function in the postnatal period of preterm pigs.

Am J Physiol Gastrointest Liver Physiol 2016 04 28;310(8):G550-60. Epub 2016 Jan 28.

Comparative Pediatrics and Nutrition, University of Copenhagen, Copenhagen, Denmark; Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Denmark.

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http://dx.doi.org/10.1152/ajpgi.00221.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836131PMC
April 2016

Searching for the physiological role of glucose-dependent insulinotropic polypeptide.

J Diabetes Investig 2016 Apr 18;7 Suppl 1:8-12. Epub 2016 Apr 18.

The NNF Center for Basic Metabolic ResearchCopnehagenDenmark; Department of Biomedical SciencesThe Panum InstituteUniversity of CopenhagenCopnehagenDenmark.

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http://dx.doi.org/10.1111/jdi.12488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854498PMC
April 2016

Glucose-Dependent Insulinotropic Polypeptide Is Associated With Lower Low-Density Lipoprotein But Unhealthy Fat Distribution, Independent of Insulin: The ADDITION-PRO Study.

J Clin Endocrinol Metab 2016 Feb 27;101(2):485-93. Epub 2015 Oct 27.

Steno Diabetes Center (C.L.M., D.V., K.F., N.B.J., M.E.J.), 2820 Gentofte, Denmark; The Danish Diabetes Academy (N.B.J., D.R.W.), 5000 Odense, Denmark; Department of Public Health, Section for General Practice (D.R.W., T.L.), Aarhus University, 8000 Aarhus, Denmark; NNF Center for Basic Metabolic Research (A.J., O.P., T.H., S.S.T., J.J.H.), University of Copenhagen, 2200 Copenhagen, Denmark; and Department of Biomedical Sciences (S.S.T., J.J.H.), Public Health, University of Copenhagen, 1014 Copenhagen, Denmark.

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http://dx.doi.org/10.1210/jc.2015-3133DOI Listing
February 2016

Do glucagonomas always produce glucagon?

Bosn J Basic Med Sci 2016 Feb 1;16(1):1-7. Epub 2016 Feb 1.

1: Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark 2: Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

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http://dx.doi.org/10.17305/bjbms.2015.794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765933PMC
February 2016

Resistant starch and protein intake enhances fat oxidation and feelings of fullness in lean and overweight/obese women.

Nutr J 2015 Oct 29;14:113. Epub 2015 Oct 29.

Human Nutrition and Metabolism Laboratory, Department of Health and Exercise Sciences, Skidmore College, 815 North Broadway, Saratoga Springs, NY, 12866, USA.

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http://nutritionj.biomedcentral.com/articles/10.1186/s12937-
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http://dx.doi.org/10.1186/s12937-015-0104-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627411PMC
October 2015