Publications by authors named "Jens C Schwamborn"

63Publications

Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient-Derived Neurons.

Mov Disord 2020 Nov 3. Epub 2020 Nov 3.

Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.

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http://dx.doi.org/10.1002/mds.28365DOI Listing
November 2020

Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids.

Cell Tissue Res 2020 Dec 31;382(3):463-476. Epub 2020 Jul 31.

Luxembourg Centre for Systems Biomedicine (LCSB), Developmental and Cellular Biology, University of Luxembourg, Belvaux, Luxembourg.

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http://dx.doi.org/10.1007/s00441-020-03249-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683480PMC
December 2020

Machine learning-assisted neurotoxicity prediction in human midbrain organoids.

Parkinsonism Relat Disord 2020 06 8;75:105-109. Epub 2020 May 8.

Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2020.05.011DOI Listing
June 2020

Quality Control Strategy for CRISPR-Cas9-Based Gene Editing Complicated by a Pseudogene.

Front Genet 2019 8;10:1297. Epub 2020 Jan 8.

Clinical and Experimental Neuroscience, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg.

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http://dx.doi.org/10.3389/fgene.2019.01297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961559PMC
January 2020

Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling.

Cereb Cortex 2020 May;30(5):3240-3258

Department of Neurosurgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China.

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http://dx.doi.org/10.1093/cercor/bhz306DOI Listing
May 2020

Non-proteolytic ubiquitination of OTULIN regulates NF-κB signaling pathway.

J Mol Cell Biol 2020 04;12(3):163-175

Department of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA.

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http://dx.doi.org/10.1093/jmcb/mjz081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181720PMC
April 2020

Automated high-throughput high-content autophagy and mitophagy analysis platform.

Sci Rep 2019 07 1;9(1):9455. Epub 2019 Jul 1.

Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 7 avenue des Hauts-Fourneaux, Esch-sur-Alzette, Luxembourg.

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http://dx.doi.org/10.1038/s41598-019-45917-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603000PMC
July 2019

Guidelines for Fluorescent Guided Biallelic HDR Targeting Selection With PiggyBac System Removal for Gene Editing.

Front Genet 2019 13;10:190. Epub 2019 Mar 13.

Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg.

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http://dx.doi.org/10.3389/fgene.2019.00190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425911PMC
March 2019

Automated microfluidic cell culture of stem cell derived dopaminergic neurons.

Sci Rep 2019 02 11;9(1):1796. Epub 2019 Feb 11.

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7 avenue des Hauts-Fourneaux, L-4362, Esch-sur-Alzette, Luxembourg.

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http://dx.doi.org/10.1038/s41598-018-34828-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370836PMC
February 2019

Millifluidic culture improves human midbrain organoid vitality and differentiation.

Lab Chip 2018 10;18(20):3172-3183

University of Luxembourg (UL), Centre for Systems Biomedicine (LCSB) - Developmental and Cellular Biology group, Luxembourg.

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http://xlink.rsc.org/?DOI=C8LC00206A
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http://dx.doi.org/10.1039/c8lc00206aDOI Listing
October 2018

A complex of the ubiquitin ligase TRIM32 and the deubiquitinase USP7 balances the level of c-Myc ubiquitination and thereby determines neural stem cell fate specification.

Cell Death Differ 2019 03 13;26(4):728-740. Epub 2018 Jun 13.

Developmental and Cellular Biology Group, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, L-4367, Belvaux, Luxembourg.

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http://dx.doi.org/10.1038/s41418-018-0144-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460386PMC
March 2019

Is Parkinson's Disease a Neurodevelopmental Disorder and Will Brain Organoids Help Us to Understand It?

Stem Cells Dev 2018 07 12;27(14):968-975. Epub 2018 Mar 12.

Luxembourg Centre for Systems Biomedicine, Developmental and Cellular Biology, University of Luxembourg , Belvaux, Luxembourg .

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http://dx.doi.org/10.1089/scd.2017.0289DOI Listing
July 2018

CRISPR/Cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and α-Synuclein modulation in dopaminergic neurons.

Stem Cell Res 2017 10 18;24:44-50. Epub 2017 Aug 18.

University of Luxembourg, Luxembourg Centre for Systems Biomedicine (LCSB), 6, avenue du Swing, L-4367 Belvaux, Luxembourg. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2017.08.013DOI Listing
October 2017

Parkinson's Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32.

Mol Neurobiol 2018 Apr 15;55(4):3490-3498. Epub 2017 May 15.

Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 6, Avenue du Swing, 4367, Belvaux, Luxembourg.

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http://dx.doi.org/10.1007/s12035-017-0570-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842508PMC
April 2018

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells.

Stem Cell Reports 2017 05 13;8(5):1144-1154. Epub 2017 Apr 13.

Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 7, avenue des Hauts-Fourneaux, 4362 Esch-sur-Alzette, Luxembourg. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425618PMC
May 2017

Environmental enrichment and physical exercise revert behavioral and electrophysiological impairments caused by reduced adult neurogenesis.

Hippocampus 2017 01 18;27(1):36-51. Epub 2016 Oct 18.

Department of Psychiatry, Laboratory of Molecular Psychiatry, University of Münster, Münster, Germany.

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http://dx.doi.org/10.1002/hipo.22669DOI Listing
January 2017

A Generalized Gene-Regulatory Network Model of Stem Cell Differentiation for Predicting Lineage Specifiers.

Stem Cell Reports 2016 09 18;7(3):307-315. Epub 2016 Aug 18.

Computational Biology Group, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7 Avenue des Hauts Fourneaux, 4362 Esch-sur-Alzette, Luxembourg. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034562PMC
September 2016

Expression of the Parkinson's Disease-Associated Gene Alpha-Synuclein is Regulated by the Neuronal Cell Fate Determinant TRIM32.

Mol Neurobiol 2017 08 23;54(6):4257-4270. Epub 2016 Jun 23.

Developmental and Cellular Biology Group, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 6 avenue du Swing, 4367, Belvaux, Luxembourg.

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http://dx.doi.org/10.1007/s12035-016-9989-9DOI Listing
August 2017

TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase.

PLoS Pathog 2015 Jun 9;11(6):e1004960. Epub 2015 Jun 9.

Department of Microbiology & Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461266PMC
June 2015

Differentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture.

Lab Chip 2015 Jun;15(11):2419-28

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7 avenue des Hauts-Fourneaux, L-4362 Esch-sur-Alzette, Luxembourg.

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http://xlink.rsc.org/?DOI=C5LC00180C
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http://dx.doi.org/10.1039/c5lc00180cDOI Listing
June 2015

The neural stem cell fate determinant TRIM32 regulates complex behavioral traits.

Front Cell Neurosci 2015 18;9:75. Epub 2015 Mar 18.

Department of Behavioural Biology, Westfälische Wilhelms-Universität Münster Münster, Germany.

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http://dx.doi.org/10.3389/fncel.2015.00075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364253PMC
April 2015

The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs.

Nucleic Acids Res 2015 Mar 26;43(5):2638-54. Epub 2015 Feb 26.

Stem Cell Biology and Regeneration Group, Institute of Cell Biology, ZMBE, Westfälische Wilhelms-Universität Münster, D-48149 Münster, Germany Developmental and Cellular Biology Group, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, L-4362 Esch-Belval, Luxembourg

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http://dx.doi.org/10.1093/nar/gkv138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357729PMC
March 2015

Gene regulatory network analysis reveals differences in site-specific cell fate determination in mammalian brain.

Front Cell Neurosci 2014 18;8:437. Epub 2014 Dec 18.

Computational Biology, Luxembourg Centre for Systems Biomedicine, University of Luxembourg Belval, Luxembourg.

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http://dx.doi.org/10.3389/fncel.2014.00437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270183PMC
January 2015

Neural stem cells in Parkinson's disease: a role for neurogenesis defects in onset and progression.

Cell Mol Life Sci 2015 Feb 18;72(4):773-97. Epub 2014 Nov 18.

Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362, Esch-sur-Alzette, Luxembourg.

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http://dx.doi.org/10.1007/s00018-014-1774-1DOI Listing
February 2015

Induced neural stem cells achieve long-term survival and functional integration in the adult mouse brain.

Stem Cell Reports 2014 Sep 31;3(3):423-31. Epub 2014 Jul 31.

Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Esch-sur-Alzette, Luxembourg; Stem Cell Biology and Regeneration Group, Institute of Cell Biology, ZMBE, Westfälische Wilhelms-University Münster, 48149 Münster, Germany. Electronic address:

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http://www.cell.com/stem-cell-reports/pdf/S2213-6711(14)0020
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http://linkinghub.elsevier.com/retrieve/pii/S221367111400203
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http://dx.doi.org/10.1016/j.stemcr.2014.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265999PMC
September 2014

The parkinson's disease-associated LRRK2 mutation R1441G inhibits neuronal differentiation of neural stem cells.

Stem Cells Dev 2013 Sep 24;22(18):2487-96. Epub 2013 May 24.

Stem Cell Biology and Regeneration Group, ZMBE, Institute of Cell Biology, Westfälische Wilhelms-Universität Münster, Münster, Germany.

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http://dx.doi.org/10.1089/scd.2013.0163DOI Listing
September 2013

Discovery of inhibitors of microglial neurotoxicity acting through multiple mechanisms using a stem-cell-based phenotypic assay.

Cell Stem Cell 2012 Nov 11;11(5):620-32. Epub 2012 Oct 11.

Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Münster, Germany.

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http://dx.doi.org/10.1016/j.stem.2012.07.005DOI Listing
November 2012

Direct reprogramming of fibroblasts into neural stem cells by defined factors.

Cell Stem Cell 2012 Apr 22;10(4):465-72. Epub 2012 Mar 22.

Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.

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http://dx.doi.org/10.1016/j.stem.2012.02.021DOI Listing
April 2012

TRIM32 regulates skeletal muscle stem cell differentiation and is necessary for normal adult muscle regeneration.

PLoS One 2012 27;7(1):e30445. Epub 2012 Jan 27.

Westfälische Wilhelms-Universität Münster, Zentrum für Molekularbiologie der Entzündung, Institute of Cell Biology, Stem Cell Biology and Regeneration Group, Münster, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030445PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267731PMC
July 2012

JAM-C is an apical surface marker for neural stem cells.

Stem Cells Dev 2012 Mar 17;21(5):757-66. Epub 2012 Jan 17.

Institute of Cell Biology, Stem Cell Biology and Regeneration Group, Westfälische Wilhelms-Universität Münster, ZMBE, Münster, Germany.

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http://dx.doi.org/10.1089/scd.2011.0274DOI Listing
March 2012

Neural stem cells maintain their stemness through protein kinase C ζ-mediated inhibition of TRIM32.

Stem Cells 2011 Sep;29(9):1437-47

Westfälische Wilhelms-Universität Münster, ZMBE, Institute of Cell Biology, Stem Cell Biology and Regeneration Group, Münster, Germany.

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http://dx.doi.org/10.1002/stem.687DOI Listing
September 2011

Cellular organization of adult neurogenesis in the Common Marmoset.

Aging Cell 2011 Feb 15;10(1):28-38. Epub 2010 Nov 15.

ZMBE, Cell Biology, Stem Cell Biology and Regeneration Group, Germany.

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http://dx.doi.org/10.1111/j.1474-9726.2010.00639.xDOI Listing
February 2011

The E3-ubiquitin ligase TRIM2 regulates neuronal polarization.

J Neurochem 2011 Apr 28;117(1):29-37. Epub 2010 Sep 28.

Department of Neurology, Westfälische Wilhelms-Universität Münster, University Hospital of Münster, Münster, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06971.xDOI Listing
April 2011

Brain tumor stem cells.

Biol Chem 2010 Jun;391(6):607-17

Center for Molecular Biology of Inflammation, Institute of Cell Biology, Stem Cell Biology and Regeneration Group, Westfälische Wilhelms-Universität Münster, Von-Esmach-Str. 56, D-48149 Münster, Germany.

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http://dx.doi.org/10.1515/BC.2010.059DOI Listing
June 2010

JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain.

BMC Neurosci 2010 Feb 26;11:27. Epub 2010 Feb 26.

Westfälische Wilhelms-Universität Münster, ZMBE, Institute for Cell Biology, Stem Cell Biology and Regeneration Group, Von-Esmarch-Str, 56, 48149 Münster, Germany.

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http://dx.doi.org/10.1186/1471-2202-11-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837050PMC
February 2010

The stimulation of dendrite growth by Sema3A requires integrin engagement and focal adhesion kinase.

J Cell Sci 2009 Jun 19;122(Pt 12):2034-42. Epub 2009 May 19.

Institut für Allgemeine Zoologie und Genetik, Westfalische Wilhelms-Universität Münster, Schlossplatz 5, D-48149 Münster, Germany.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.038232
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http://dx.doi.org/10.1242/jcs.038232DOI Listing
June 2009

LIS1 and spindle orientation in neuroepithelial cells.

Cell Stem Cell 2008 Mar;2(3):193-4

Institute of Molecular Biotechnology of Austrian Academy of Sciences, Dr. Bohr-Gasse 3, 1030 Vienna, Austria.

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http://dx.doi.org/10.1016/j.stem.2008.02.010DOI Listing
March 2008

The interaction of mPar3 with the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity.

J Biol Chem 2007 Nov 28;282(48):35259-68. Epub 2007 Sep 28.

Abteilung Molekularbiologie, Institut für Allgemeine Zoologie und Genetik, Westfälische Wilhelms-Universität Münster, Schlossplatz 5, D-48149 Münster, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M703438200
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http://dx.doi.org/10.1074/jbc.M703438200DOI Listing
November 2007

Ubiquitination of the GTPase Rap1B by the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity.

EMBO J 2007 Mar 22;26(5):1410-22. Epub 2007 Feb 22.

Abteilung Molekularbiologie, Institut für Allgemeine Zoologie und Genetik, Westfälische Wilhelms-Universität Münster, Münster, Germany.

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http://dx.doi.org/10.1038/sj.emboj.7601580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1817628PMC
March 2007

GTPases and the control of neuronal polarity.

Methods Enzymol 2006 ;406:715-27

Institut fur Allgemeine Zoologie and Genetik, Westfalische Wilhelms Universitat, Munster, Germany.

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http://dx.doi.org/10.1016/S0076-6879(06)06056-3DOI Listing
March 2006

The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity.

Nat Neurosci 2004 Sep 1;7(9):923-9. Epub 2004 Aug 1.

Abteilung Molekularbiologie, Institut für Allgemeine Zoologie und Genetik, Westfälische Wilhelms-Universität Münster, Germany.

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http://dx.doi.org/10.1038/nn1295DOI Listing
September 2004

Semaphorin 3A stimulates neurite extension and regulates gene expression in PC12 cells.

J Biol Chem 2004 Jul 20;279(30):30923-6. Epub 2004 May 20.

Institut für Allgemeine Zoologie und Genetik, Westfälische Wilhelms-Universität Münster, Schlossplatz 5, D-48149 Münster, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.C400082200
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http://dx.doi.org/10.1074/jbc.C400082200DOI Listing
July 2004