Publications by authors named "Jens C Bruning"

100Publications

Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo.

Mol Metab 2020 Sep 19;42:101085. Epub 2020 Sep 19.

Max Planck Institute for Metabolism Research, Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), Cologne, 50931, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), Germany; Center for Molecular Medicine Cologne, University of Cologne, Cologne, 50931, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2020.101085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560164PMC
September 2020

GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function.

Cell Metab 2020 Jun 19;31(6):1189-1205.e13. Epub 2020 May 19.

Max Planck Institute for Metabolism Research, Department of Neuronal Control of Metabolism, Gleueler Str. 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Str. 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany; National Center for Diabetes Research (DZD), Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2020.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272126PMC
June 2020

MCH Neurons Regulate Permeability of the Median Eminence Barrier.

Neuron 2020 07 13;107(2):306-319.e9. Epub 2020 May 13.

Max Planck Institute for Metabolism Research, Department of Neuronal Control of Metabolism, Gleueler Str. 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Str. 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany; National Center for Diabetes Research (DZD), Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2020.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383232PMC
July 2020

PNOC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding.

Neuron 2020 06 16;106(6):1009-1025.e10. Epub 2020 Apr 16.

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes, and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2020.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303947PMC
June 2020

The role of ceramides in metabolic disorders: when size and localization matters.

Nat Rev Endocrinol 2020 04 14;16(4):224-233. Epub 2020 Feb 14.

Max Planck Institute for Metabolism Research, Köln, Germany.

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http://dx.doi.org/10.1038/s41574-020-0320-5DOI Listing
April 2020

NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons.

Nat Commun 2020 01 23;11(1):442. Epub 2020 Jan 23.

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931, Cologne, Germany.

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http://dx.doi.org/10.1038/s41467-020-14291-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978463PMC
January 2020

mA RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment.

Cell Rep 2019 08;28(7):1703-1716.e6

Molecular Pharmacology Program, Center for Cell Engineering, Center for Stem Cell Biology, Center for Experimental Therapeutics, Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.07.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818972PMC
August 2019

Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation.

J Allergy Clin Immunol 2020 01 8;145(1):283-300.e8. Epub 2019 Aug 8.

Department of Dermatology, University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.07.033DOI Listing
January 2020

The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons.

Cell Rep 2019 06;27(11):3182-3198.e9

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany; National Center for Diabetes Research (DZD), Ingolstädter Land Strasse 1, 85764 Neuherberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193065
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http://dx.doi.org/10.1016/j.celrep.2019.05.037DOI Listing
June 2019

CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity.

Cell 2019 05;177(6):1536-1552.e23

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne; National Center for Diabetes Research (DZD), Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193050
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http://dx.doi.org/10.1016/j.cell.2019.05.008DOI Listing
May 2019

Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions.

Cell Metab 2019 07 25;30(1):111-128.e6. Epub 2019 Apr 25.

Neuroscience Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia; Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131193018
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http://dx.doi.org/10.1016/j.cmet.2019.04.001DOI Listing
July 2019

Modulation of midbrain neurocircuitry by intranasal insulin.

Neuroimage 2019 07 23;194:120-127. Epub 2019 Mar 23.

Max-Planck-Institute for Metabolism Research, Cologne, Germany; Modern Diet and Physiology Center, USA; Cologne Cluster of Excellence in Cellular Stress and Aging-Associated Disease (CECAD), Cologne, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10538119193025
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http://dx.doi.org/10.1016/j.neuroimage.2019.03.050DOI Listing
July 2019

CerS1-Derived C Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance.

Cell Rep 2019 01;26(1):1-10.e7

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany; National Center for Diabetes Research (DZD), Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.12.031DOI Listing
January 2019

Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans.

Cell Metab 2019 03 27;29(3):695-706.e4. Epub 2018 Dec 27.

Max Planck Institute for Metabolism Research, Cologne, Germany; Cologne Cluster of Excellence in Cellular Stress and Aging-Associated Disease (CECAD), Cologne, Germany; Modern Diet and Physiology Research Center, New Haven, CT, USA.

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http://dx.doi.org/10.1016/j.cmet.2018.12.006DOI Listing
March 2019

Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation.

Cell 2018 11;175(5):1321-1335.e20

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany; National Center for Diabetes Research (DZD), Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541012PMC
November 2018

Hepatic leptin receptor expression can partially compensate for IL-6Rα deficiency in DEN-induced hepatocellular carcinoma.

Mol Metab 2018 11 5;17:122-133. Epub 2018 Sep 5.

Max Planck Institute for Metabolism Research, Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), Cologne, 50931, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197506PMC
November 2018

Melanin-Concentrating Hormone-Dependent Control of Feeding: When Volume Matters.

Cell Metab 2018 07;28(1):7-8

Max Planck Institute for Metabolism Research, Department of Neuronal Control of Metabolism, Gleueler Str. 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Str. 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.06.018DOI Listing
July 2018

Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a Pomc-Somatostatin-Growth Hormone Circuit.

Cell Rep 2018 05;23(6):1728-1741

Institute of Zoology, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.04.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015746PMC
May 2018

TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding.

Diabetes 2018 07 30;67(7):1246-1257. Epub 2018 Apr 30.

Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Melbourne, Victoria, Australia

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http://dx.doi.org/10.2337/db17-1485DOI Listing
July 2018

VEGF and GLUT1 are highly heritable, inversely correlated and affected by dietary fat intake: Consequences for cognitive function in humans.

Mol Metab 2018 05 12;11:129-136. Epub 2018 Feb 12.

Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal 14558, Germany; German Center for Diabetes Research (DZD), München-Neuherberg 85764, Germany; Department of Endocrinology, Diabetes and Nutrition, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin 12200, Germany.

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http://dx.doi.org/10.1016/j.molmet.2018.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001408PMC
May 2018

N-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response.

Mol Cell 2018 02 8;69(4):636-647.e7. Epub 2018 Feb 8.

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816726PMC
February 2018

Corrigendum to "Insulin controls food intake and energy balance via NPY neurons" [Mol Metabol 6 (2017) 574-584].

Mol Metab 2017 11 8;6(11):1562. Epub 2017 Jul 8.

Neuroscience Division, Garvan Institute of Medical Research, St Vincent's Hospital, Sydney, 2010, Australia; Faculty of Medicine, UNSW, 2052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2017.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681235PMC
November 2017

A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding.

Cell Metab 2017 Aug;26(2):375-393.e7

Metabolic Disease and Obesity Program, Biomedicine Discovery Institute, Monash University, Victoria 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.07.013DOI Listing
August 2017

The Sense of Smell Impacts Metabolic Health and Obesity.

Cell Metab 2017 Jul;26(1):198-211.e5

Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA; The Paul F. Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.06.015DOI Listing
July 2017

IL-6/Stat3-Dependent Induction of a Distinct, Obesity-Associated NK Cell Subpopulation Deteriorates Energy and Glucose Homeostasis.

Cell Metab 2017 Jul;26(1):171-184.e6

Max-Planck-Institute for Metabolism Research, Gleueler Straße 50, 50931 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, 50924 Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.05.018DOI Listing
July 2017

Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity.

Dis Model Mech 2017 06;10(6):679-689

Max Planck Institute for Metabolism Research, Department of Neuronal Control of Metabolism, Gleueler Str. 50, Cologne 50931, Germany

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http://dx.doi.org/10.1242/dmm.026609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483000PMC
June 2017

Insulin controls food intake and energy balance via NPY neurons.

Mol Metab 2017 06 12;6(6):574-584. Epub 2017 Apr 12.

Neuroscience Division, Garvan Institute of Medical Research, St Vincent's Hospital, Sydney, 2010, Australia.

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http://dx.doi.org/10.1016/j.molmet.2017.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444095PMC
June 2017

Neuronal control of peripheral insulin sensitivity and glucose metabolism.

Nat Commun 2017 05 4;8:15259. Epub 2017 May 4.

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany.

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http://dx.doi.org/10.1038/ncomms15259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418592PMC
May 2017

IL-6 Regulates M2 Polarization and Local Proliferation of Adipose Tissue Macrophages in Obesity.

J Immunol 2017 04 13;198(7):2927-2934. Epub 2017 Feb 13.

Institute of Anatomy, Leipzig University, 04317 Leipzig, Germany;

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http://dx.doi.org/10.4049/jimmunol.1600476DOI Listing
April 2017

Hypothalamic inflammation in obesity and metabolic disease.

J Clin Invest 2017 01 3;127(1):24-32. Epub 2017 Jan 3.

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http://dx.doi.org/10.1172/JCI88878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199695PMC
January 2017

Insulin-Dependent Activation of MCH Neurons Impairs Locomotor Activity and Insulin Sensitivity in Obesity.

Cell Rep 2016 12;17(10):2512-2521

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany; National Center for Diabetes Research (DZD), Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.030DOI Listing
December 2016

Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue.

Cell Rep 2016 10;17(4):1008-1021

Urologische Klinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66, 79106 Freiburg, Germany; BIOSS Centre of Biological Signalling Studies, Albert Ludwigs University, 79106 Freiburg, Germany; Deutsches Konsortium für Translationale Krebsforschung (DKTK), Standort Freiburg, 79108 Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.09.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081406PMC
October 2016

Hunger-Driven Motivational State Competition.

Neuron 2016 Oct 29;92(1):187-201. Epub 2016 Sep 29.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20892, USA; National Institute on Drug Abuse (NIDA), National Institutes of Health, Baltimore, MD 21224, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082717PMC
http://dx.doi.org/10.1016/j.neuron.2016.08.032DOI Listing
October 2016

Neuroendocrinology: Electromagnetogenetic Control over Feeding and Glucose Metabolism.

Curr Biol 2016 06;26(11):R470-3

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany. Electronic address:

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http://linkinghub.elsevier.com/retrieve/pii/S096098221630397
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http://dx.doi.org/10.1016/j.cub.2016.04.044DOI Listing
June 2016

Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity.

Cell 2016 May 28;165(4):882-95. Epub 2016 Apr 28.

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, Joseph Stelzmann Strasse 26, 50931 Cologne, Germany; National Center for Diabetes Research (DZD), Ingolstädter Land Strasse 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.03.033DOI Listing
May 2016

Sweet Mitochondrial Dynamics in VMH Neurons.

Cell Metab 2016 Apr;23(4):577-9

Max-Planck-Institute for Metabolism Research, Gleueler Strasse 50a, 50931 Köln, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Ageing Associated Diseases (CECAD), Joseph-Stelzmann-Strasse 26, 50931 Köln, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital, Joseph-Stelzmann-Strasse 26, 50931 Köln, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.03.014DOI Listing
April 2016

AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue.

Cell 2016 Mar;165(1):125-138

Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany; National Center for Diabetes Research (DZD) Ingolstädter Land Strasse 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.02.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157157PMC
March 2016

FTO gene variant modulates the neural correlates of visual food perception.

Neuroimage 2016 Mar 5;128:21-31. Epub 2016 Jan 5.

Max Planck Institute for Metabolism Research, 50931 Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuroimage.2015.12.049DOI Listing
March 2016

Metabolism: Light on leptin link to lipolysis.

Nature 2015 Nov;527(7576):43-4

Max Planck Institute for Metabolism Research, Cologne 50931, Germany.

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http://dx.doi.org/10.1038/527043aDOI Listing
November 2015

Hypothalamic UDP Increases in Obesity and Promotes Feeding via P2Y6-Dependent Activation of AgRP Neurons.

Cell 2015 Sep;162(6):1404-17

Max Planck Institute for Metabolism Research, Department of Neuronal Control of Metabolism, Gleueler Str. 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany; National Center for Diabetes Research (DZD), Ingolstädter Land Str. 1, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.08.032DOI Listing
September 2015

NK cells link obesity-induced adipose stress to inflammation and insulin resistance.

Nat Immunol 2015 Apr 2;16(4):376-85. Epub 2015 Mar 2.

Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.

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http://dx.doi.org/10.1038/ni.3120DOI Listing
April 2015

Ceramide synthase 4 regulates stem cell homeostasis and hair follicle cycling.

J Invest Dermatol 2015 Jun 23;135(6):1501-1509. Epub 2015 Feb 23.

Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1038/jid.2015.60DOI Listing
June 2015

Central insulin signaling modulates hypothalamus-pituitary-adrenal axis responsiveness.

Mol Metab 2015 Feb 10;4(2):83-92. Epub 2014 Dec 10.

Naomi Berrie Diabetes Center, Columbia University, New York, NY 10032, USA ; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.molmet.2014.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314547PMC
February 2015

Versatile functions for IL-6 in metabolism and cancer.

Trends Immunol 2015 Feb 21;36(2):92-101. Epub 2015 Jan 21.

Max Planck Institute for Metabolism Research, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.it.2014.12.008DOI Listing
February 2015

Meta-analysis of global metabolomic data identifies metabolites associated with life-span extension.

Metabolomics 2014 Aug;10(4):737-743

Departments of Chemistry and Molecular Biology, The Center for Mass Spectrometry and Metabolomics, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1007/s11306-013-0608-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267291PMC
August 2014

Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance.

Cell Rep 2014 Nov 13;9(4):1495-506. Epub 2014 Nov 13.

Department of Mouse Genetics and Metabolism, Institute for Genetics, Cologne 50674, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), Cologne 50931, Germany; Center for Molecular Medicine (CMMC), University of Cologne, Cologne 50931, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Cologne 50937, Germany; Max Planck Institute for Metabolism Research, Cologne 50931, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.10.045DOI Listing
November 2014

Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.

Cell Metab 2014 Oct;20(4):678-86

Max Planck Institute for Metabolism Research, Cologne, North Rhine-Westphalia 50931, Germany; CECAD, Cologne, North Rhine-Westphalia 50931, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Cologne, North Rhine-Westphalia 50931, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.08.002DOI Listing
October 2014

Die another day: a painless path to longevity.

Cell 2014 May;157(5):1004-6

Max-Planck-Institute for Neurological Research, Gleueler Strasse 50a, 50931 Köln, Germany; Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne and Center for Molecular Medicine Cologne (CMMC), Zülpicher Strasse 47a, 50674 Köln, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Ageing Associated Diseases (CECAD), Zülpicher Str. 47a, 50674 Köln, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.05.013DOI Listing
May 2014

Regulation of metabolism by long, non-coding RNAs.

Front Genet 2014 25;5:57. Epub 2014 Mar 25.

Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases Köln, Germany ; Max-Planck-Institute for Neurological Research Köln, Germany ; Department of Mouse Genetics and Metabolism and Center for Molecular Medicine Cologne, Institute for Genetics at the University Hospital of Cologne, University of Cologne Cologne, Germany ; Center for Endocrinology, Diabetes and Preventive Medicine, University Hospital Cologne, University of Cologne, Cologne Germany.

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http://dx.doi.org/10.3389/fgene.2014.00057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971185PMC
June 2014

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin.

Nat Immunol 2014 May 30;15(5):423-30. Epub 2014 Mar 30.

1] Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Cologne, Germany. [2] Max Planck Institute for Neurological Research, Cologne, Germany. [3] Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Cologne, Germany. [4] Center for Endocrinology, Diabetes and Preventive Medicine, University Hospital Cologne, Cologne, Germany. [5] Center for Molecular Medicine Cologne, Cologne, Germany.

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http://dx.doi.org/10.1038/ni.2865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161471PMC
May 2014

The paradox of neuronal insulin action and resistance in the development of aging-associated diseases.

Alzheimers Dement 2014 Feb;10(1 Suppl):S3-11

Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, Köln, Germany; Center for Endocrinology, Diabetes and Preventive Medicine, University Hospital Cologne, Köln, Germany; Center for Molecular Medicine Cologne, Köln, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Ageing Associated Diseases, Köln, Germany; Max-Planck-Institute for Neurological Research, Köln, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2013.12.008DOI Listing
February 2014

The fat mass and obesity-associated (FTO) gene: Obesity and beyond?

Biochim Biophys Acta 2014 Oct 8;1842(10):2039-47. Epub 2014 Feb 8.

Max Planck Institute for Neurological Research, D-50931 Cologne, Germany; Department of Mouse Genetics and Metabolism, Institute for Genetics, Center of Molecular Medicine Cologne (CMMC), D-50674 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), D-50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital of Cologne, D-50931 Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.01.017DOI Listing
October 2014

Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding.

Cell 2014 Jan 23;156(3):495-509. Epub 2014 Jan 23.

Max Planck Institute for Neurological Research, 50931 Cologne, Germany; Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, 50674 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, 50674 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, 50924 Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101521PMC
January 2014

Signaling through the adaptor molecule MyD88 in CD4+ T cells is required to overcome suppression by regulatory T cells.

Immunity 2014 Jan;40(1):78-90

Department of Immunobiology, Yale University, New Haven, CT 06519, USA; Howard Hughes Medical Institute, School of Medicine, Yale University, New Haven, CT 06519, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2013.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445716PMC
January 2014

Obesity: The need to eat--overruling the homeostatic control of feeding.

Nat Rev Endocrinol 2014 Jan 26;10(1):5-6. Epub 2013 Nov 26.

Max Planck Institute for Neurological Research, Gleueler Straße 50, D-50931 Cologne, Germany.

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http://dx.doi.org/10.1038/nrendo.2013.235DOI Listing
January 2014

K(ATP)-channel-dependent regulation of catecholaminergic neurons controls BAT sympathetic nerve activity and energy homeostasis.

Cell Metab 2013 Sep;18(3):445-55

Department of Mouse Genetics and Metabolism, Institute for Genetics and Center for Molecular Medicine (CMMC), University of Cologne, Zülpicher Strasse 47b, 50674 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Zülpicher Strasse 47b, 50674 Cologne, Germany; Max Planck Institute for Neurological Research, Gleueler Strasse 50, 50931 Cologne, Germany.

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http://dx.doi.org/10.1016/j.cmet.2013.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684875PMC
September 2013

Obesity promotes liver carcinogenesis via Mcl-1 stabilization independent of IL-6Rα signaling.

Cell Rep 2013 Aug 15;4(4):669-80. Epub 2013 Aug 15.

Max Planck Institute for Neurological Research Cologne, Institute for Genetics, University of Cologne, 50937 Cologne, Germany.

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http://dx.doi.org/10.1016/j.celrep.2013.07.023DOI Listing
August 2013

Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.

Endocrinology 2013 Jul 13;154(7):2410-20. Epub 2013 May 13.

Research and Development Division, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2013-1261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689283PMC
July 2013

Delayed puberty but normal fertility in mice with selective deletion of insulin receptors from Kiss1 cells.

Endocrinology 2013 Mar 7;154(3):1337-48. Epub 2013 Feb 7.

Center for Diabetes and Endocrine Research, University of Toledo College of Medicine, Toledo, OH 43614, USA.

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http://dx.doi.org/10.1210/en.2012-2056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578993PMC
March 2013

Perinatal programming of metabolic diseases: role of insulin in the development of hypothalamic neurocircuits.

Endocrinol Metab Clin North Am 2013 Mar 13;42(1):149-64. Epub 2012 Dec 13.

Department of Mouse Genetics and Metabolism, University Hospital Cologne and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Köln 50674, Germany.

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http://dx.doi.org/10.1016/j.ecl.2012.10.002DOI Listing
March 2013

Novel approaches to the pharmacotherapy of obesity.

Curr Pharm Des 2013 ;19(27):4938-52

Center of Endocrinology, Diabetes and Preventive Medicine, University of Cologne, Kerpener St. 62, 50937 Cologne, Germany.

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http://dx.doi.org/10.2174/13816128113199990302DOI Listing
February 2014

CNS insulin signaling in the control of energy homeostasis and glucose metabolism - from embryo to old age.

Trends Endocrinol Metab 2013 Feb 19;24(2):76-84. Epub 2012 Dec 19.

Max Planck Institute for Neurological Research, D-50931 Cologne, Germany.

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http://dx.doi.org/10.1016/j.tem.2012.11.004DOI Listing
February 2013

MyomiRs-133a/b turn off the heat.

Nat Cell Biol 2012 Dec;14(12):1248-9

Max Planck Institute for Neurological Research, Gleueler Street 50a, 50931 Köln, Germany.

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http://dx.doi.org/10.1038/ncb2642DOI Listing
December 2012

Adipocyte dysfunction in a mouse model of polycystic ovary syndrome (PCOS): evidence of adipocyte hypertrophy and tissue-specific inflammation.

PLoS One 2012 31;7(10):e48643. Epub 2012 Oct 31.

Department of Physiology and Pharmacology, Center for Diabetes and Endocrine Research, University of Toledo Medical Center, Toledo, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048643PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485364PMC
May 2013

Acute selective ablation of rat insulin promoter-expressing (RIPHER) neurons defines their orexigenic nature.

Proc Natl Acad Sci U S A 2012 Oct 11;109(44):18132-7. Epub 2012 Oct 11.

Institute for Genetics, Department of Mouse Genetics and Metabolism, Center for Molecular Medicine, and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, 50674 Cologne, Germany.

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http://dx.doi.org/10.1073/pnas.1206147109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497747PMC
October 2012

Selective insulin and leptin resistance in metabolic disorders.

Cell Metab 2012 Aug;16(2):144-52

Department of Mouse Genetics and Metabolism, Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Center of Molecular Medicine Cologne, University of Cologne, D-50674 Cologne, Germany.

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http://dx.doi.org/10.1016/j.cmet.2012.07.004DOI Listing
August 2012

Vascular endothelial insulin/IGF-1 signaling controls skin wound vascularization.

Biochem Biophys Res Commun 2012 May 4;421(2):197-202. Epub 2012 Apr 4.

Department of Dermatology, University of Cologne, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2012.03.134DOI Listing
May 2012

Cutting edge: Inhibition of IL-6 trans-signaling protects from malaria-induced lethality in mice.

J Immunol 2012 May 30;188(9):4141-4. Epub 2012 Mar 30.

Center of Molecular Medicine Cologne, Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, Institute for Genetics Cologne, Max Planck Institute for Neurological Research Cologne, D-50931 Cologne, Germany.

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http://dx.doi.org/10.4049/jimmunol.1102137DOI Listing
May 2012

Mapping leptin's link to reproduction.

Mol Metab 2012 9;1(1-2):5-7. Epub 2012 Aug 9.

Department of Mouse Genetics and Metabolism, Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), Center of Molecular Medicine Cologne (CMMC), University of Cologne, D-50674 Cologne, Germany ; Max Planck Institute for Neurological Research, Gleueler Str. 50, D-50931 Cologne, Germany ; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, D-50924 Cologne, Germany.

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http://dx.doi.org/10.1016/j.molmet.2012.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757656PMC
September 2013

Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner.

Endocrinology 2011 Dec 11;152(12):4825-37. Epub 2011 Oct 11.

Jesse Brown Veterans Affairs Medical Center, Research and Development Division, 820 South Damen Avenue, Chicago, Illinois 60612, USA.

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http://dx.doi.org/10.1210/en.2011-1447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230054PMC
December 2011