Jenny P-Y Ting

Jenny P-Y Ting

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Jenny P-Y Ting

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Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR.

J Exp Med 2019 Dec 26;216(12):2838-2853. Epub 2019 Sep 26.

Oral and Craniofacial Biomedicine PhD Program, University of North Carolina at Chapel Hill, Chapel Hill, NC

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http://dx.doi.org/10.1084/jem.20190111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888982PMC
December 2019

The NLRP3 inflammasome: molecular activation and regulation to therapeutics.

Nat Rev Immunol 2019 08;19(8):477-489

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://www.nature.com/articles/s41577-019-0165-0
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http://dx.doi.org/10.1038/s41577-019-0165-0DOI Listing
August 2019

A microparticle platform for STING-targeted immunotherapy enhances natural killer cell- and CD8 T cell-mediated anti-tumor immunity.

Biomaterials 2019 Jun 14;205:94-105. Epub 2019 Mar 14.

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Institute for Inflammatory Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Center for Translational Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2019.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594365PMC
June 2019

NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25.

Cell Host Microbe 2019 04 19;25(4):602-616.e7. Epub 2019 Mar 19.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA; Institute of Inflammatory Diseases, Center for Translational Immunology, University of North Carolina, Chapel Hill, NC, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19313128193010
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http://dx.doi.org/10.1016/j.chom.2019.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459718PMC
April 2019

Identification of a Locus in Mice that Regulates the Collateral Damage and Lethality of Virus Infection.

Cell Rep 2019 04;27(5):1387-1396.e5

Department of Genetics, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, UNC-Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508094PMC
April 2019

Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon.

Immunity 2019 03;50(3):591-599.e6

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613193007
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http://dx.doi.org/10.1016/j.immuni.2019.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469509PMC
March 2019

The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity.

Immunity 2018 12;49(6):1049-1061.e6

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10747613183044
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http://dx.doi.org/10.1016/j.immuni.2018.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532657PMC
December 2018

Investigation of tunable acetalated dextran microparticle platform to optimize M2e-based influenza vaccine efficacy.

J Control Release 2018 11 24;289:114-124. Epub 2018 Sep 24.

Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2018.09.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365168PMC
November 2018

A spike in inflammation.

Nat Nanotechnol 2018 11;13(11):980-981

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://www.nature.com/articles/s41565-018-0292-y
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http://dx.doi.org/10.1038/s41565-018-0292-yDOI Listing
November 2018

The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis.

Cell Host Microbe 2018 09;24(3):364-378.e6

Lineberger Comprehensive Cancer Center, UNC-Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, UNC-Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, UNC-Chapel Hill, Chapel Hill, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161752PMC
September 2018

A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination.

J Control Release 2018 01 21;270:1-13. Epub 2017 Nov 21.

Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Institute for Inflammatory Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Center for Translational Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2017.11.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808851PMC
January 2018

A noncanonical function of cGAMP in inflammasome priming and activation.

J Exp Med 2017 Dec 13;214(12):3611-3626. Epub 2017 Oct 13.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC

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http://dx.doi.org/10.1084/jem.20171749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716045PMC
December 2017

Reversing SKI-SMAD4-mediated suppression is essential for T17 cell differentiation.

Nature 2017 11 25;551(7678):105-109. Epub 2017 Oct 25.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1038/nature24283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743442PMC
November 2017

NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes.

J Exp Med 2017 05 12;214(5):1351-1370. Epub 2017 Apr 12.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

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http://dx.doi.org/10.1084/jem.20150237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413320PMC
May 2017

NLRX1 negatively modulates type I IFN to facilitate KSHV reactivation from latency.

PLoS Pathog 2017 May 1;13(5):e1006350. Epub 2017 May 1.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426799PMC
May 2017

An NLRP3 Mutation Causes Arthropathy and Osteoporosis in Humanized Mice.

Cell Rep 2016 12;17(11):3077-3088

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.052DOI Listing
December 2016

MAVS-dependent host species range and pathogenicity of human hepatitis A virus.

Science 2016 09 15;353(6307):1541-1545. Epub 2016 Sep 15.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27517, USA. Department of Medicine, University of North Carolina, Chapel Hill, NC 27517, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068972PMC
http://dx.doi.org/10.1126/science.aaf8325DOI Listing
September 2016

Reining in uncontrolled inflammasome with PKA.

Nat Immunol 2016 09;17(10):1137-8

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, the Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, the Center for Translational Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, and the Institute for Inflammatory Diseases, University of North Carolina at Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/ni.3556DOI Listing
September 2016

Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1β Secretion: A Primary Human Monocyte Model.

PLoS One 2015 24;10(8):e0136708. Epub 2015 Aug 24.

Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; The Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America; Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136708PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547738PMC
May 2016

Influenza A Virus NS1 Protein Inhibits the NLRP3 Inflammasome.

PLoS One 2015 15;10(5):e0126456. Epub 2015 May 15.

Virus-Host Interactions Laboratory, Department of Biosystems and Biotechnology, Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 136-713, Republic of Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126456PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433236PMC
March 2016

The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals.

Cell Rep 2016 Mar 10;14(11):2562-75. Epub 2016 Mar 10.

The Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7295, USA; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599-7295, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247163018
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http://dx.doi.org/10.1016/j.celrep.2016.02.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853907PMC
March 2016

The pathogenic role of the inflammasome in neurodegenerative diseases.

J Neurochem 2016 Jan 2;136 Suppl 1:29-38. Epub 2015 Sep 2.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://doi.wiley.com/10.1111/jnc.13217
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http://dx.doi.org/10.1111/jnc.13217DOI Listing
January 2016

Tumor Presence Induces Global Immune Changes and Enhances Nanoparticle Clearance.

ACS Nano 2016 Jan 2;10(1):861-70. Epub 2015 Dec 2.

Department of Chemical and Biomolecular Engineering, North Carolina State University , Raleigh, North Carolina 27695, United States.

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http://dx.doi.org/10.1021/acsnano.5b05999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761267PMC
January 2016

Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.

Cell Host Microbe 2015 Sep 27;18(3):320-32. Epub 2015 Aug 27.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA; Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19313128150030
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http://dx.doi.org/10.1016/j.chom.2015.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567510PMC
September 2015

Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.

Nat Med 2015 Aug 24;21(8):906-13. Epub 2015 Jun 24.

1] Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA. [2] Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. [3] Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/nm.3908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529369PMC
August 2015

NLRP3 moonlights in TH2 polarization.

Nat Immunol 2015 Aug;16(8):794-6

Center for Immunology &Microbial Disease, Albany Medical College, Albany, New York, USA.

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http://dx.doi.org/10.1038/ni.3223DOI Listing
August 2015

NLRP12 provides a critical checkpoint for osteoclast differentiation.

Proc Natl Acad Sci U S A 2015 Aug 3;112(33):10455-60. Epub 2015 Aug 3.

Musculoskeletal Research Center, Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110; Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110

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http://dx.doi.org/10.1073/pnas.1500196112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547270PMC
August 2015

Spleen Tyrosine Kinase (Syk) Mediates IL-1β Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection.

J Biol Chem 2015 Jul 1;290(28):17306-20. Epub 2015 Jun 1.

From the Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Department of Genetics, and Institute of Inflammatory Diseases, University of North Carolina, Chapel Hill, North Carolina 27599 and

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http://dx.doi.org/10.1074/jbc.M115.664136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498069PMC
July 2015

Inflammasomes: mechanism of action, role in disease, and therapeutics.

Nat Med 2015 Jul 29;21(7):677-87. Epub 2015 Jun 29.

1] The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [2] Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/nm.3893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519035PMC
July 2015

Analysis of human innate immune responses to PRINT fabricated nanoparticles with cross validation using a humanized mouse model.

Nanomedicine 2015 Apr 14;11(3):589-99. Epub 2015 Jan 14.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Center for Translational Immunology and Institute of Inflammatory Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2014.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385431PMC
April 2015

Controlled analysis of nanoparticle charge on mucosal and systemic antibody responses following pulmonary immunization.

Proc Natl Acad Sci U S A 2015 Jan 29;112(2):488-93. Epub 2014 Dec 29.

Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695; and Lineberger Comprehensive Cancer Center, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 Chemistry, and

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http://dx.doi.org/10.1073/pnas.1422923112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299250PMC
January 2015

HIV-1 infection induces interleukin-1β production via TLR8 protein-dependent and NLRP3 inflammasome mechanisms in human monocytes.

J Biol Chem 2014 Aug 17;289(31):21716-26. Epub 2014 Jun 17.

From the Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599

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http://dx.doi.org/10.1074/jbc.M114.566620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118130PMC
August 2014

Inflammasomes and metabolic disorders: old genes in modern diseases.

Mol Cell 2014 Apr;54(2):297-308

The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.03.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084585PMC
April 2014

NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.

Immunity 2014 Mar 20;40(3):329-41. Epub 2014 Feb 20.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Institute of Inflammatory Diseases and Center for Translational Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011014PMC
March 2014

Toward a molecular pathogenic pathway for Yersinia pestis YopM.

Front Cell Infect Microbiol 2012 11;2:155. Epub 2012 Dec 11.

Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky Lexington, KY, USA.

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http://dx.doi.org/10.3389/fcimb.2012.00155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518861PMC
December 2013

Analysis of the murine immune response to pulmonary delivery of precisely fabricated nano- and microscale particles.

PLoS One 2013 12;8(4):e62115. Epub 2013 Apr 12.

Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062115PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625166PMC
October 2013

Mechanisms of NOD-like receptor-associated inflammasome activation.

Immunity 2013 Sep;39(3):432-41

The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.immuni.2013.08.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835203PMC
September 2013

Nanoparticle clearance is governed by Th1/Th2 immunity and strain background.

J Clin Invest 2013 Jul 17;123(7):3061-73. Epub 2013 Jun 17.

Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1172/JCI66895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696555PMC
July 2013

Agitation by suffocation: how hypoxia activates innate immunity via the Warburg effect.

Cell Metab 2013 Jun;17(6):814-5

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.cmet.2013.05.016DOI Listing
June 2013

The NLR protein, NLRX1, and its partner, TUFM, reduce type I interferon, and enhance autophagy.

Autophagy 2013 Mar 15;9(3):432-3. Epub 2013 Jan 15.

Department of Diagnostic Sciences, School of Dental Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

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http://dx.doi.org/10.4161/auto.23026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590269PMC
March 2013

Plexin-B2 and Plexin-D1 in dendritic cells: expression and IL-12/IL-23p40 production.

PLoS One 2012 15;7(8):e43333. Epub 2012 Aug 15.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043333PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419716PMC
January 2013

Atopic asthmatic patients have reduced airway inflammatory cell recruitment after inhaled endotoxin challenge compared with healthy volunteers.

J Allergy Clin Immunol 2012 Oct 4;130(4):869-76.e2. Epub 2012 Jul 4.

Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27516, USA.

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http://dx.doi.org/10.1016/j.jaci.2012.05.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652253PMC
October 2012

Porphyromonas gingivalis mediates inflammasome repression in polymicrobial cultures through a novel mechanism involving reduced endocytosis.

J Biol Chem 2012 Sep 26;287(39):32791-9. Epub 2012 Jul 26.

Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1074/jbc.M112.401737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463344PMC
September 2012

NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice.

J Immunol 2012 Aug 29;189(4):2006-16. Epub 2012 Jun 29.

Pulmonary Division, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.4049/jimmunol.1201065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635067PMC
August 2012

IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis.

J Immunol 2012 Aug 11;189(4):1792-9. Epub 2012 Jul 11.

Department of Medicine, Center for Gastrointestinal Biology and Diseases, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.4049/jimmunol.1200042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411910PMC
August 2012

Regulation of class I major histocompatibility complex (MHC) by nucleotide-binding domain, leucine-rich repeat-containing (NLR) proteins.

J Biol Chem 2012 Jul 29;287(29):24294-303. Epub 2012 May 29.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, the Institute of Inflammatory Diseases and Center of Translational Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7295, USA.

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http://dx.doi.org/10.1074/jbc.M112.364604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397855PMC
July 2012

Characterization of NLRP12 during the development of allergic airway disease in mice.

PLoS One 2012 23;7(1):e30612. Epub 2012 Jan 23.

Lineberger Comprehensive Cancer Center, Institute of Inflammatory Diseases and Center for Translational Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030612PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264608PMC
June 2012

Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation.

PLoS One 2011 23;6(9):e24795. Epub 2011 Sep 23.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024795PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179467PMC
March 2012

Analysis of NLRP3 in the development of allergic airway disease in mice.

J Immunol 2012 Mar 8;188(6):2884-93. Epub 2012 Feb 8.

Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.4049/jimmunol.1102488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294123PMC
March 2012

A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?

Nat Immunol 2012 Mar 19;13(4):352-7. Epub 2012 Mar 19.

Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/ni.2228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090390PMC
March 2012

NLRX1 has a tail to tell.

Immunity 2012 Mar;36(3):311-2

Structural Immunobiology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.immuni.2012.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658283PMC
March 2012

Cross-regulation between the IL-1β/IL-18 processing inflammasome and other inflammatory cytokines.

Curr Opin Immunol 2011 Oct 10;23(5):591-7. Epub 2011 Aug 10.

Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.coi.2011.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380339PMC
October 2011

Monocytic microparticles activate endothelial cells in an IL-1β-dependent manner.

Blood 2011 Aug 23;118(8):2366-74. Epub 2011 Jun 23.

Division of Hematology and Oncology, Department of Medicine, McAllister Heart Institute, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1182/blood-2011-01-330878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162361PMC
August 2011

The inflammasome NLRs in immunity, inflammation, and associated diseases.

Annu Rev Immunol 2011 ;29:707-35

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599, USA.

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http://www.annualreviews.org/doi/10.1146/annurev-immunol-031
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http://dx.doi.org/10.1146/annurev-immunol-031210-101405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067317PMC
June 2011

Plexin-D1 is a novel regulator of germinal centers and humoral immune responses.

J Immunol 2011 May 4;186(10):5603-11. Epub 2011 Apr 4.

Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.4049/jimmunol.1003464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771081PMC
May 2011

Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling.

Nat Immunol 2011 May 10;12(5):408-15. Epub 2011 Apr 10.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/ni.2022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090391PMC
May 2011

DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB.

J Biol Chem 2011 Feb 19;286(6):4098-106. Epub 2010 Nov 19.

Department of Microbiology-Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7295, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.147371
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039338PMC
February 2011

Cutting edge: NLRC5-dependent activation of the inflammasome.

J Immunol 2011 Feb 29;186(3):1333-7. Epub 2010 Dec 29.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.4049/jimmunol.1003111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669680PMC
February 2011

Discovery of a viral NLR homolog that inhibits the inflammasome.

Science 2011 Jan;331(6015):330-4

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1126/science.1199478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072027PMC
January 2011

Plexin-A4-semaphorin 3A signaling is required for Toll-like receptor- and sepsis-induced cytokine storm.

J Exp Med 2010 Dec 22;207(13):2943-57. Epub 2010 Nov 22.

Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1084/jem.20101138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005237PMC
December 2010