Jenny J Yang

Jenny J Yang

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Jenny J Yang

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Precision detection of liver metastasis by collagen-targeted protein MRI contrast agent.

Biomaterials 2019 Dec 6;224:119478. Epub 2019 Sep 6.

Department of Chemistry, Georgia State University, Atlanta, GA, 30303, USA; Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA, 30303, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2019.119478DOI Listing
December 2019

Designing Calcium-Binding Proteins for Molecular MR Imaging.

Methods Mol Biol 2019 ;1929:111-125

Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA, USA.

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http://link.springer.com/10.1007/978-1-4939-9030-6_8
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http://dx.doi.org/10.1007/978-1-4939-9030-6_8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542288PMC
June 2019

Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities After Ischemic Stroke in Adult Mice.

Neurotherapeutics 2018 07;15(3):770-784

Department of Anesthesiology, Emory University School of Medicine, 101 Woodruff Circle, Woodruff Memorial Research Building, Suite 620B, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1007/s13311-018-0635-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095793PMC
July 2018

Correction to: Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities after Ischemic Stroke in Adult Mice.

Neurotherapeutics 2018 07;15(3):836

Department of Anesthesiology, Emory University School of Medicine, 101 Woodruff Circle, Woodruff Memorial Research, Building, Suite 620B, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1007/s13311-018-0645-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095791PMC
July 2018

Radiologic and Histopathologic Correlation of Different Growth Patterns of Metastatic Uveal Melanoma to the Liver.

Ophthalmology 2018 04 6;125(4):597-605. Epub 2017 Nov 6.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia; Department of Pathology, Emory University School of Medicine, Atlanta, Georgia. Electronic address:

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http://dx.doi.org/10.1016/j.ophtha.2017.09.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211288PMC
April 2018

Direct visualization of interaction between calmodulin and connexin45.

Biochem J 2017 11 27;474(24):4035-4051. Epub 2017 Nov 27.

Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, U.S.A.

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http://biochemj.org/lookup/doi/10.1042/BCJ20170426
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http://dx.doi.org/10.1042/BCJ20170426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976250PMC
November 2017

Calcium Dynamics Mediated by the Endoplasmic/Sarcoplasmic Reticulum and Related Diseases.

Int J Mol Sci 2017 May 10;18(5). Epub 2017 May 10.

Department of Chemistry, Center for Diagnostics and Therapeutics (CDT), Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.3390/ijms18051024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454937PMC
May 2017

Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER.

J Vis Exp 2017 05 19(123). Epub 2017 May 19.

Department of Chemistry, Center of Diagnostics and Therapeutics (CDT), Georgia State University;

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http://dx.doi.org/10.3791/55822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608000PMC
May 2017

Molecular Basis for Modulation of Metabotropic Glutamate Receptors and Their Drug Actions by Extracellular Ca.

Int J Mol Sci 2017 Mar 21;18(3). Epub 2017 Mar 21.

Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.3390/ijms18030672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372683PMC
March 2017

Towards the Molecular Imaging of Prostate Cancer Biomarkers Using Protein-based MRI Contrast Agents.

Curr Protein Pept Sci 2016 ;17(6):519-33

Department of Chemistry, Center for Diagnostics & Therapeutics (CDT), Center for Biotechnology and Drug Design, Georgia State University, 50 Decatur Street, SE., Atlanta, GA 30303, USA.

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http://dx.doi.org/10.2174/1389203717666160101123725DOI Listing
February 2017

The hills and valleys of calcium signaling.

Sci China Life Sci 2016 Aug 10;59(8):743-8. Epub 2016 Aug 10.

Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, 30303, USA.

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http://dx.doi.org/10.1007/s11427-016-5098-2DOI Listing
August 2016

Prostate-specific membrane antigen targeted protein contrast agents for molecular imaging of prostate cancer by MRI.

Nanoscale 2016 Jul 10;8(25):12668-82. Epub 2016 Mar 10.

Departments of Chemistry, Center for Diagnostics & Therapeutics, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1039/c5nr09071gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528195PMC
July 2016

Defining potential roles of Pb(2+) in neurotoxicity from a calciomics approach.

Metallomics 2016 06;8(6):563-78

Department of Chemistry, Center for Diagnostics and Therapeutics, and Drug Design and Biotechnology, Georgia State University, Atlanta, GA 3030, USA.

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http://dx.doi.org/10.1039/c6mt00038jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979543PMC
June 2016

ProCA1.GRPR: a new imaging agent in cancer detection.

Biomark Med 2016 05 13;10(5):449-52. Epub 2016 Apr 13.

Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.2217/bmm-2016-0040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493961PMC
May 2016

Role of Ca2+ and L-Phe in regulating functional cooperativity of disease-associated "toggle" calcium-sensing receptor mutations.

PLoS One 2014 24;9(11):e113622. Epub 2014 Nov 24.

Department of Chemistry, Georgia State University, Atlanta, Georgia, United States of America; Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113622PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242666PMC
January 2016

GRPR-targeted Protein Contrast Agents for Molecular Imaging of Receptor Expression in Cancers by MRI.

Sci Rep 2015 Nov 18;5:16214. Epub 2015 Nov 18.

Departments of Chemistry and Biology, Center for Diagnostics &Therapeutics, Georgia State University, Atlanta, GA 30303.

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http://dx.doi.org/10.1038/srep16214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649707PMC
November 2015

Fast kinetics of calcium signaling and sensor design.

Curr Opin Chem Biol 2015 Aug 4;27:90-7. Epub 2015 Jul 4.

Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13675931150007
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http://dx.doi.org/10.1016/j.cbpa.2015.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553074PMC
August 2015

Effect of Ca²⁺ on the steady-state and time-resolved emission properties of the genetically encoded fluorescent sensor CatchER.

J Phys Chem B 2015 Feb 5;119(6):2103-11. Epub 2014 Jun 5.

Department of Chemistry, Georgia State University , Atlanta, Georgia 30303, United States.

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http://pubs.acs.org/doi/10.1021/jp501707n
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http://dx.doi.org/10.1021/jp501707nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329989PMC
February 2015

The calcium sensing receptor: from calcium sensing to signaling.

Sci China Life Sci 2015 Jan 10;58(1):14-27. Epub 2015 Jan 10.

Department of Chemistry, Georgia State University, Atlanta, Georgia, 30303, USA.

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http://dx.doi.org/10.1007/s11427-014-4779-yDOI Listing
January 2015

Direct determination of multiple ligand interactions with the extracellular domain of the calcium-sensing receptor.

J Biol Chem 2014 Nov 10;289(48):33529-42. Epub 2014 Oct 10.

From the Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia 30303,

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http://www.jbc.org/lookup/doi/10.1074/jbc.M114.604652
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http://dx.doi.org/10.1074/jbc.M114.604652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246106PMC
November 2014

Design of ProCAs (protein-based Gd(3+) MRI contrast agents) with high dose efficiency and capability for molecular imaging of cancer biomarkers.

Med Res Rev 2014 Sep 11;34(5):1070-99. Epub 2014 Mar 11.

Departments of Chemistry and Biology, Georgia State University, Atlanta, Georgia; Center for Diagnostics & Therapeutics (CDT), Georgia State University, Atlanta, Georgia; Center for Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia.

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http://doi.wiley.com/10.1002/med.21313
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http://dx.doi.org/10.1002/med.21313DOI Listing
September 2014

Pyruvate kinase M2 in blood circulation facilitates tumor growth by promoting angiogenesis.

J Biol Chem 2014 Sep 28;289(37):25812-21. Epub 2014 Jul 28.

From the Department of Biology and

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http://dx.doi.org/10.1074/jbc.M114.576934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162182PMC
September 2014

Myoplasmic resting Ca2+ regulation by ryanodine receptors is under the control of a novel Ca2+-binding region of the receptor.

Biochem J 2014 Jun;460(2):261-71

‡Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, 20 Shattuck Street, Boston, MA 02115, U.S.A.

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http://biochemj.org/lookup/doi/10.1042/BJ20131553
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http://dx.doi.org/10.1042/BJ20131553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019983PMC
June 2014

Gap junction regulation by calmodulin.

FEBS Lett 2014 Apr 16;588(8):1430-8. Epub 2014 Jan 16.

Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, United States. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2014.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989380PMC
April 2014

Molecular imaging of EGFR/HER2 cancer biomarkers by protein MRI contrast agents.

J Biol Inorg Chem 2014 Feb 24;19(2):259-70. Epub 2013 Dec 24.

Department of Chemistry, Georgia State University, 50 Decatur Street, 550 NSC, Atlanta, GA, 30303, USA.

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http://dx.doi.org/10.1007/s00775-013-1076-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931309PMC
February 2014

Identification of an L-phenylalanine binding site enhancing the cooperative responses of the calcium-sensing receptor to calcium.

J Biol Chem 2014 Feb 6;289(8):5296-309. Epub 2014 Jan 6.

From the Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia 30303 and.

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http://dx.doi.org/10.1074/jbc.M113.537357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931085PMC
February 2014

Extracellular calcium modulates actions of orthosteric and allosteric ligands on metabotropic glutamate receptor 1α.

J Biol Chem 2014 Jan 26;289(3):1649-61. Epub 2013 Nov 26.

From the Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia 30303.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M113.507665
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http://dx.doi.org/10.1074/jbc.M113.507665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894344PMC
January 2014

Prostate cancer metastatic to bone has higher expression of the calcium-sensing receptor (CaSR) than primary prostate cancer.

Receptors Clin Investig 2014;1(6)

Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia 30303.

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http://dx.doi.org/10.14800/rci.270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459757PMC
January 2014

Structural basis for a hand-like site in the calcium sensor CatchER with fast kinetics.

Acta Crystallogr D Biol Crystallogr 2013 Dec 19;69(Pt 12):2309-19. Epub 2013 Nov 19.

Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1107/S0907444913021306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852649PMC
December 2013

Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers.

Wiley Interdiscip Rev Nanomed Nanobiotechnol 2013 Mar-Apr;5(2):163-79. Epub 2013 Jan 17.

Departments of Chemistry and Biology, Center for Diagnostics & Therapeutics, Georgia State University, Atlanta, GA, USA.

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http://dx.doi.org/10.1002/wnan.1205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011496PMC
August 2013

Metal toxicity and opportunistic binding of Pb(2+) in proteins.

J Inorg Biochem 2013 Aug 19;125:40-9. Epub 2013 Apr 19.

Department of Chemistry, Center for Diagnostics and Therapeutics and Drug Design and Biotechnology, Georgia State University, Atlanta, GA, 30303, United States.

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http://dx.doi.org/10.1016/j.jinorgbio.2013.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947799PMC
August 2013

Probing Ca2+-binding capability of viral proteins with the EF-hand motif by grafting approach.

Methods Mol Biol 2013 ;963:37-53

Department of Chemistry, Georgia State University, Atlanta, GA, USA.

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http://dx.doi.org/10.1007/978-1-62703-230-8_3DOI Listing
June 2013

Interaction between p68 RNA helicase and Ca2+-calmodulin promotes cell migration and metastasis.

Nat Commun 2013 ;4:1354

Department of Biology, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.1038/ncomms2345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552336PMC
June 2013

Reciprocal regulation of protein kinase and pyruvate kinase activities of pyruvate kinase M2 by growth signals.

J Biol Chem 2013 May 10;288(22):15971-9. Epub 2013 Apr 10.

Department of Biology, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.1074/jbc.M112.448753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668752PMC
May 2013

Calciomics: integrative studies of Ca2+-binding proteins and their interactomes in biological systems.

Metallomics 2013 Jan;5(1):29-42

Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, TX 77030, USA.

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http://xlink.rsc.org/?DOI=C2MT20009K
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http://dx.doi.org/10.1039/c2mt20009kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614492PMC
January 2013

Predicting Ca2+ -binding sites using refined carbon clusters.

Proteins 2012 Dec 31;80(12):2666-79. Epub 2012 Jul 31.

Department of Mathematics and Statistics, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1002/prot.24149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486949PMC
December 2012

Gating of connexin 43 gap junctions by a cytoplasmic loop calmodulin binding domain.

Am J Physiol Cell Physiol 2012 May 14;302(10):C1548-56. Epub 2012 Mar 14.

Department of Pharmacology, SUNY Upstate Medical University, 750 East Adams St., Syracuse, NY 13210, USA

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http://dx.doi.org/10.1152/ajpcell.00319.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361999PMC
May 2012

Residual sarcoplasmic reticulum Ca2+ concentration after Ca2+ release in skeletal myofibers from young adult and old mice.

Pflugers Arch 2012 Apr 17;463(4):615-24. Epub 2012 Jan 17.

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC, 27157, USA.

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http://dx.doi.org/10.1007/s00424-012-1073-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319114PMC
April 2012

Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase.

Mol Cell 2012 Mar 2;45(5):598-609. Epub 2012 Feb 2.

Department of Biology, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1016/j.molcel.2012.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299833PMC
March 2012

Design and application of a class of sensors to monitor Ca2+ dynamics in high Ca2+ concentration cellular compartments.

Proc Natl Acad Sci U S A 2011 Sep 13;108(39):16265-70. Epub 2011 Sep 13.

Department of Chemistry, Center for Drug Design and Biotechnology, Georgia State University, Atlanta, GA 30303, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1103015108
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http://dx.doi.org/10.1073/pnas.1103015108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182728PMC
September 2011

Calmodulin regulates Ca2+-sensing receptor-mediated Ca2+ signaling and its cell surface expression.

J Biol Chem 2010 Nov 8;285(46):35919-31. Epub 2010 Sep 8.

Department of Chemistry, Center for Drug Design and Advanced Biotechnology, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.1074/jbc.M110.147918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975215PMC
November 2010

Elucidation of a novel extracellular calcium-binding site on metabotropic glutamate receptor 1{alpha} (mGluR1{alpha}) that controls receptor activation.

J Biol Chem 2010 Oct 12;285(43):33463-74. Epub 2010 Aug 12.

Department of Chemistry, Center for Drug Design and Advanced Biotechnology, Georgia State University, Atlanta, Georgia 30303, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.147033
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http://dx.doi.org/10.1074/jbc.M110.147033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963343PMC
October 2010

Calcium-dependent association of calmodulin with the rubella virus nonstructural protease domain.

J Biol Chem 2010 Mar 19;285(12):8855-68. Epub 2010 Jan 19.

Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.1074/jbc.M109.097063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838307PMC
March 2010

Integration of Diverse Research Methods to Analyze and Engineer Ca-Binding Proteins: From Prediction to Production.

Curr Bioinform 2010 Mar;5(1):68-80

Department of Chemistry, Center for Drug Design and Biotechnology, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.2174/157489310790596358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927018PMC
March 2010

Inverse tuning of metal binding affinity and protein stability by altering charged coordination residues in designed calcium binding proteins.

PMC Biophys 2009 Dec 21;2:11. Epub 2009 Dec 21.

Department of Chemistry, Center for Drug Design and Biotechnology, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1186/1757-5036-2-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816670PMC
December 2009

A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+.

FEBS J 2009 Oct 20;276(19):5589-97. Epub 2009 Aug 20.

Department of Chemistry, Center for Drug Design and Advanced Biotechnology, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2009.07240.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866080PMC
October 2009

Designing caspase-3 sensors for imaging of apoptosis in living cells.

Chemistry 2009 Sep;15(37):9311-4

Department of Chemistry, Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30303, USA.

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http://doi.wiley.com/10.1002/chem.200901439
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http://dx.doi.org/10.1002/chem.200901439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480176PMC
September 2009

Fluorescence complementation via EF-hand interactions.

J Biotechnol 2009 Jul 11;142(3-4):205-13. Epub 2009 Jun 11.

Department of Chemistry, Center for Drug Design and Advanced Biotechnology, Georgia State University, Atlanta, GA 30302, USA.

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http://dx.doi.org/10.1016/j.jbiotec.2009.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866105PMC
July 2009

Viral calciomics: interplays between Ca2+ and virus.

Cell Calcium 2009 Jul 16;46(1):1-17. Epub 2009 Jun 16.

Department of Chemistry, Georgia State University, 50 Decatur St., Atlanta, GA 30303 USA.

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http://dx.doi.org/10.1016/j.ceca.2009.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449087PMC
July 2009

Facilitating chromophore formation of engineered Ca(2+) binding green fluorescent proteins.

Arch Biochem Biophys 2009 Jun 7;486(1):27-34. Epub 2009 Apr 7.

Department of Chemistry and Center for Drug Design and Advanced Biotechnology, Georgia State University, 50 Decatur Street, Atlanta, GA 30302, USA.

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http://dx.doi.org/10.1016/j.abb.2009.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774846PMC
June 2009

Designing protease sensors for real-time imaging of trypsin activation in pancreatic cancer cells.

Biochemistry 2009 Apr;48(15):3519-26

Department of Chemistry, Center for Drug Design and Biotechnology, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.1021/bi802289vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739378PMC
April 2009

Calmodulin mediates the Ca2+-dependent regulation of Cx44 gap junctions.

Biophys J 2009 Apr;96(7):2832-48

Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.1016/j.bpj.2008.12.3941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711270PMC
April 2009

Multiple Ca(2+)-binding sites in the extracellular domain of the Ca(2+)-sensing receptor corresponding to cooperative Ca(2+) response.

Biochemistry 2009 Jan;48(2):388-98

Department of Chemistry, Center of Drug Design and Advanced Biotechnology, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.1021/bi8014604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627791PMC
January 2009

Structural differences between Pb2+- and Ca2+-binding sites in proteins: implications with respect to toxicity.

J Inorg Biochem 2008 Oct 5;102(10):1901-9. Epub 2008 Jul 5.

Center for Drug Design and Biotechnology, Department of Chemistry, Georgia State University, 50 Decatur Street, 550 NSC, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1016/j.jinorgbio.2008.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567809PMC
October 2008

Rational design of a conformation-switchable Ca2+- and Tb3+-binding protein without the use of multiple coupled metal-binding sites.

FEBS J 2008 Oct 10;275(20):5048-61. Epub 2008 Sep 10.

Department of Chemistry, Center of Drug Design and Biotechnology, Georgia State University, Atlanta, GA, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2008.06638.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613763PMC
October 2008

Statistical analysis of structural characteristics of protein Ca2+-binding sites.

J Biol Inorg Chem 2008 Sep 2;13(7):1169-81. Epub 2008 Jul 2.

Department of Chemistry, Center for Drug Design and Biotechnology, Georgia State University, Atlanta, GA 30303, USA.

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September 2008

Rational design of protein-based MRI contrast agents.

J Am Chem Soc 2008 Jul 25;130(29):9260-7. Epub 2008 Jun 25.

Department of Chemistry, Center for Drug Design and Advanced Biotechnology, Georgia State University, Atlanta, Georgia 30303, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692035PMC
July 2008

Rational design of a novel calcium-binding site adjacent to the ligand-binding site on CD2 increases its CD48 affinity.

Protein Sci 2008 Mar;17(3):439-49

Department of Chemistry, Center for Drug Design and Biotechnology, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.1110/ps.073328208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248323PMC
March 2008

Identification of the calmodulin binding domain of connexin 43.

J Biol Chem 2007 Nov 27;282(48):35005-17. Epub 2007 Sep 27.

Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, USA.

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November 2007

Developing sensors for real-time measurement of high Ca2+ concentrations.

Biochemistry 2007 Oct 9;46(43):12275-88. Epub 2007 Oct 9.

Department of Chemistry and Biology, Center for Drug Design and Biotechnology, Georgia State University, Atlanta, Georgia 30303, USA.

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October 2007

Identification and dissection of Ca(2+)-binding sites in the extracellular domain of Ca(2+)-sensing receptor.

J Biol Chem 2007 Jun 3;282(26):19000-10. Epub 2007 May 3.

Department of Chemistry, Center for Biotechnology and Drug Design Georgia State University, Atlanta, Georgia 30303, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867057PMC
June 2007

Functional elements on SIRPalpha IgV domain mediate cell surface binding to CD47.

J Mol Biol 2007 Jan 3;365(3):680-93. Epub 2006 Oct 3.

Department of Biology, Georgia State University, Atlanta, GA 30302, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855148PMC
January 2007

Prediction of EF-hand calcium-binding proteins and analysis of bacterial EF-hand proteins.

Proteins 2006 Nov;65(3):643-55

Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, USA.

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November 2006

Predicting calcium-binding sites in proteins - a graph theory and geometry approach.

Proteins 2006 Jul;64(1):34-42

Department of Computer Science, Georgia State University, Atlanta, Georgia 30302, USA.

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July 2006

Using protein design to dissect the effect of charged residues on metal binding and protein stability.

Biochemistry 2006 May;45(18):5848-56

Department of Chemistry, Center for Drug Design and Biotechnology, Georgia State University, Atlanta, Georgia 30303, USA.

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May 2006

Amyloid fibril formation by a domain of rat cell adhesion molecule.

Cell Biochem Biophys 2006 ;44(2):241-9

Department of Chemistry, Center of Drug Design, Georgia State University, Atlanta, GA, USA.

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April 2006

Expression and optical properties of green fluorescent protein expressed in different cellular environments.

J Biotechnol 2005 Oct;119(4):368-78

Department of Chemistry, Center for Drug Design and Biotechnology, Georgia State University, Atlanta, GA 30303, USA.

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October 2005

Calcium and lanthanide affinity of the EF-loops from the C-terminal domain of calmodulin.

J Inorg Biochem 2005 Jun;99(6):1376-83

Department of Chemistry, Center of Drug Design, Georgia State University, University Plaza, Atlanta, GA 30303, USA.

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June 2005

The effects of Ca2+ binding on the dynamic properties of a designed Ca2+-binding protein.

Biochemistry 2005 Jun;44(23):8267-73

Department of Chemistry, Center for Drug Design, Georgia State University, Atlanta, Georgia 30303, USA.

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June 2005

Probing site-specific calmodulin calcium and lanthanide affinity by grafting.

J Am Chem Soc 2005 Mar;127(11):3743-50

Department of Chemistry, Center for Drug Design and Advanced Biotechnology, Georgia State University, Atlanta, Georgia 30303, USA.

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March 2005

Design of a calcium-binding protein with desired structure in a cell adhesion molecule.

J Am Chem Soc 2005 Feb;127(7):2085-93

Department of Chemistry, Center for Drug Design and Biotechnology, Georgia State University, Atlanta, Georgia 30303, USA.

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February 2005

Obtaining site-specific calcium-binding affinities of calmodulin.

Protein Pept Lett 2003 Aug;10(4):331-45

Department of Chemistry and Center for Drug Design and Advanced Biotechnology, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.2174/0929866033478852DOI Listing
August 2003

A grafting approach to obtain site-specific metal-binding properties of EF-hand proteins.

Protein Eng 2003 Jun;16(6):429-34

Department of Chemistry, Center of Drug Design, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1093/protein/gzg051DOI Listing
June 2003

Rational design of a calcium-binding protein.

J Am Chem Soc 2003 May;125(20):6165-71

Department of Chemistry, Center of Drug Design, Georgia State University, Atlanta 30303, USA.

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http://dx.doi.org/10.1021/ja034724xDOI Listing
May 2003

Temperature-induced formation of a non-native intermediate state of the all beta-sheet protein CD2.

Cell Biochem Biophys 2002 ;36(1):1-18

Department of Chemistry, Center of Drug Design, Georgia State University, Atlanta 30303, USA.

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October 2002

Isolated EF-loop III of calmodulin in a scaffold protein remains unpaired in solution using pulsed-field-gradient NMR spectroscopy.

Biochim Biophys Acta 2002 Jul;1598(1-2):80-7

Department of Chemistry, Center of Drug Design, Georgia State University, 50 Decatur Street, Atlanta, GA 30303, USA.

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July 2002

Metal-binding studies for a de novo designed calcium-binding protein.

Protein Eng 2002 Jul;15(7):571-4

Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.

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July 2002

Structural analysis, identification, and design of calcium-binding sites in proteins.

Proteins 2002 May;47(3):344-56

Department of Biology Drug Design, Georgia State University, Atlanta, Georgia, USA.

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May 2002

Design, synthesis, and characterization of a calcium-sensitive near infrared dye.

Talanta 2002 Apr;56(6):1099-107

Department of Chemistry, Center for Drug Design and Advanced Biotechnology, Georgia State University, Atlanta, GA 30303, USA.

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April 2002