Publications by authors named "Jennifer S Dickey"

31Publications

Reproductive hormone levels and differential mitochondria-related oxidative gene expression as potential mechanisms for gender differences in cardiosensitivity to Doxorubicin in tumor-bearing spontaneously hypertensive rats.

Cancer Chemother Pharmacol 2015 Sep 25;76(3):447-59. Epub 2015 Jun 25.

Laboratory of Chemistry, Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave/Bldg 52/72 Rm 2212, Silver Spring, MD, 20993, USA.

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http://dx.doi.org/10.1007/s00280-015-2786-8DOI Listing
September 2015

Regulatory perspective on minimal residual disease flow cytometry testing in multiple myeloma.

Cytometry B Clin Cytom 2016 Jan 25;90(1):73-80. Epub 2015 Jul 25.

Center for Drug Evaluation and Research (CDER) and Center for Devices and Radiologic Health (CDRH), Food and Drug Administration (FDA).

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http://doi.wiley.com/10.1002/cyto.b.21268
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http://dx.doi.org/10.1002/cyto.b.21268DOI Listing
January 2016

The first FDA marketing authorizations of next-generation sequencing technology and tests: challenges, solutions and impact for future assays.

Expert Rev Mol Diagn 2015 Jan 5;15(1):33-40. Epub 2014 Nov 5.

Division of Molecular Genetics and Pathology, Office of In Vitro Diagnostics and Radiological Health (OIR), CDRH, US FDA, 10903 New Hampshire Ave, Silver Spring, 20993, USA.

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http://dx.doi.org/10.1586/14737159.2015.979795DOI Listing
January 2015

Systemic DNA damage accumulation under in vivo tumor growth can be inhibited by the antioxidant Tempol.

Cancer Lett 2014 Oct 25;353(2):248-57. Epub 2014 Jul 25.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, Vic. 3002, Australia; Laboratory of Molecular Radiation Biology, Peter MacCallum Cancer Centre, Vic. 3002, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Vic. 3002, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2014.07.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167057PMC
October 2014

Susceptibility to bystander DNA damage is influenced by replication and transcriptional activity.

Nucleic Acids Res 2012 Nov 31;40(20):10274-86. Epub 2012 Aug 31.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20952, USA.

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http://dx.doi.org/10.1093/nar/gks795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488239PMC
November 2012

The role of miRNA in the direct and indirect effects of ionizing radiation.

Radiat Environ Biophys 2011 Nov 18;50(4):491-9. Epub 2011 Sep 18.

Laboratory of Biochemistry, Division of Therapeutic Proteins, CDER, FDA, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s00411-011-0386-5DOI Listing
November 2011

Systemic DNA damage related to cancer.

Cancer Res 2011 May 10;71(10):3437-41. Epub 2011 May 10.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-4579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096754PMC
May 2011

Para-inflammation mediates systemic DNA damage in response to tumor growth.

Commun Integr Biol 2011 Jan;4(1):78-81

Laboratory of Molecular Pharmacology; Center for Cancer Research; National Cancer Institute; Bethesda, MD USA.

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http://dx.doi.org/10.4161/cib.4.1.13942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073278PMC
January 2011

The iron chelator Dp44mT inhibits the proliferation of cancer cells but fails to protect from doxorubicin-induced cardiotoxicity in spontaneously hypertensive rats.

Cancer Chemother Pharmacol 2011 Nov 4;68(5):1125-34. Epub 2011 Mar 4.

Laboratory of Biochemistry, Center for Drug Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Building 29A, Room 2A-11, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s00280-011-1587-yDOI Listing
November 2011

H2AX phosphorylation in response to DNA double-strand break formation during bystander signalling: effect of microRNA knockdown.

Radiat Prot Dosimetry 2011 Feb 23;143(2-4):264-9. Epub 2010 Dec 23.

Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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https://academic.oup.com/rpd/article-lookup/doi/10.1093/rpd/
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http://dx.doi.org/10.1093/rpd/ncq470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108274PMC
February 2011

Tumors induce complex DNA damage in distant proliferative tissues in vivo.

Proc Natl Acad Sci U S A 2010 Oct 20;107(42):17992-7. Epub 2010 Sep 20.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1008260107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964229PMC
October 2010

The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinone.

J Biol Chem 2010 Nov 30;285(45):34447-59. Epub 2010 Aug 30.

Laboratory of Biochemistry, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1074/jbc.M110.133579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966059PMC
November 2010

microRNAome changes in bystander three-dimensional human tissue models suggest priming of apoptotic pathways.

Carcinogenesis 2010 Oct 19;31(10):1882-8. Epub 2010 Jul 19.

Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, T1K 3M4 Canada.

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http://dx.doi.org/10.1093/carcin/bgq119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950932PMC
October 2010

Role of oxidatively induced DNA lesions in human pathogenesis.

Mutat Res 2010 Apr-Jun;704(1-3):152-9. Epub 2010 Jan 8.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.mrrev.2009.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074954PMC
August 2010

γ-H2AX as a biomarker of DNA damage induced by ionizing radiation in human peripheral blood lymphocytes and artificial skin.

Adv Space Res 2009 ;43(8):1171-1178

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, D.H.H.S., Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1016/j.asr.2008.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735274PMC
January 2009

H2AX: functional roles and potential applications.

Chromosoma 2009 Dec 26;118(6):683-92. Epub 2009 Aug 26.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s00412-009-0234-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094848PMC
December 2009

Intercellular communication of cellular stress monitored by gamma-H2AX induction.

Carcinogenesis 2009 Oct 3;30(10):1686-95. Epub 2009 Aug 3.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20952, USA.

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http://dx.doi.org/10.1093/carcin/bgp192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757548PMC
October 2009

GammaH2AX and cancer.

Nat Rev Cancer 2008 Dec 13;8(12):957-67. Epub 2008 Nov 13.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nrc2523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094856PMC
December 2008

gamma-H2AX in bystander cells: not just a radiation-triggered event, a cellular response to stress mediated by intercellular communication.

Cell Cycle 2007 Sep 5;6(18):2210-2. Epub 2007 Jul 5.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20895, USA.

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http://dx.doi.org/10.4161/cc.6.18.4682DOI Listing
September 2007

Ability of viral topoisomerase II to discern the handedness of supercoiled DNA: bimodal recognition of DNA geometry by type II enzymes.

Biochemistry 2006 Sep;45(38):11674-80

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA.

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http://dx.doi.org/10.1021/bi0520838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517260PMC
September 2006

DNA methylation impacts the cleavage activity of Chlorella virus topoisomerase II.

Biochemistry 2005 Nov;44(46):15378-86

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA.

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http://dx.doi.org/10.1021/bi051334+DOI Listing
November 2005

Impact of the C-terminal domain of topoisomerase IIalpha on the DNA cleavage activity of the human enzyme.

Biochemistry 2005 Aug;44(34):11546-54

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA.

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http://dx.doi.org/10.1021/bi050811lDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678941PMC
August 2005

Chlorella virus Marburg topoisomerase II: high DNA cleavage activity as a characteristic of Chlorella virus type II enzymes.

Biochemistry 2005 Mar;44(10):3899-908

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA.

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http://pubs.acs.org/doi/abs/10.1021/bi047777f
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http://dx.doi.org/10.1021/bi047777fDOI Listing
March 2005

Site-specific DNA cleavage by Chlorella virus topoisomerase II.

Biochemistry 2002 Oct;41(39):11761-9

Departments of Biochemistry and Medicine (Hematology/Oncology), Vanderbilt University School of Medicine, Nashville, TN 37232-0146, USA.

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http://dx.doi.org/10.1021/bi025802gDOI Listing
October 2002