Jennifer R Grandis

Jennifer R Grandis

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Jennifer R Grandis

Publications by authors named "Jennifer R Grandis"

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Gene targets of sulforaphane in head and neck squamous cell carcinoma.

Mol Med Rep 2019 Dec 23;20(6):5335-5344. Epub 2019 Oct 23.

Department of Otolaryngology‑Head and Neck Surgery, University of California at San Francisco, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.3892/mmr.2019.10766DOI Listing
December 2019

Targeting STAT3 in Cancer with Nucleotide Therapeutics.

Cancers (Basel) 2019 Oct 29;11(11). Epub 2019 Oct 29.

Department Otolaryngology-Head and Neck Surgery, University of California at San Francisco, 1450 3rd Street, Room HD268, Box 3111, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.3390/cancers11111681DOI Listing
October 2019

NSAID therapy for PIK3CA-Altered colorectal, breast, and head and neck cancer.

Adv Biol Regul 2019 Sep 15:100653. Epub 2019 Sep 15.

Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2019.100653DOI Listing
September 2019

ATR inhibition sensitizes HPV and HPV head and neck squamous cell carcinoma to cisplatin.

Oral Oncol 2019 Aug 6;95:35-42. Epub 2019 Jun 6.

Department of Otolaryngology, University of California, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2019.05.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827881PMC
August 2019

HER3 targeting potentiates growth suppressive effects of the PI3K inhibitor BYL719 in pre-clinical models of head and neck squamous cell carcinoma.

Sci Rep 2019 Jun 24;9(1):9130. Epub 2019 Jun 24.

Department of Otolaryngology-Head & Neck Surgery, University of Pittsburgh Medical Center, Eye and Ear Institute, Suite 500, 200 Lothrop St., Pittsburgh, PA, 15213, USA.

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http://dx.doi.org/10.1038/s41598-019-45589-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591241PMC
June 2019

Investigational multitargeted kinase inhibitors in development for head and neck neoplasms.

Expert Opin Investig Drugs 2019 04 26;28(4):351-363. Epub 2019 Feb 26.

a Department of Otolaryngology - Head and Neck Surgery , University of California , San Francisco , CA , USA.

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http://dx.doi.org/10.1080/13543784.2019.1581172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857634PMC
April 2019

An update: emerging drugs to treat squamous cell carcinomas of the head and neck.

Expert Opin Emerg Drugs 2018 12 16;23(4):283-299. Epub 2018 Nov 16.

a Department of Otolaryngology-Head and Neck Surgery , University of California , San Francisco , CA , USA.

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https://www.tandfonline.com/doi/full/10.1080/14728214.2018.1
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http://dx.doi.org/10.1080/14728214.2018.1543400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525082PMC
December 2018

BET Inhibition Overcomes Receptor Tyrosine Kinase-Mediated Cetuximab Resistance in HNSCC.

Cancer Res 2018 08 23;78(15):4331-4343. Epub 2018 May 23.

Department of Otolaryngology and Head and Neck Surgery, University of California San Francisco, San Francisco, California.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-0459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072571PMC
August 2018

New Therapies in Head and Neck Cancer.

Trends Cancer 2018 05 19;4(5):385-396. Epub 2018 Apr 19.

Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2018.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226306PMC
May 2018

Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription Factor.

Int J Mol Sci 2018 May 30;19(6). Epub 2018 May 30.

Department of Otolaryngology-Head and Neck Surgery, University of California at San Francisco, San Francisco, CA 94115, USA.

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http://dx.doi.org/10.3390/ijms19061608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032396PMC
May 2018

Targeting the IL-6/JAK/STAT3 signalling axis in cancer.

Nat Rev Clin Oncol 2018 04 6;15(4):234-248. Epub 2018 Feb 6.

Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, CA, USA.

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http://www.nature.com/doifinder/10.1038/nrclinonc.2018.8
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http://dx.doi.org/10.1038/nrclinonc.2018.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858971PMC
April 2018

The Fusion Gene Induces Cancer Stem Cell-like Properties and Therapeutic Resistance in Nasopharyngeal Carcinoma.

Clin Cancer Res 2018 02 13;24(3):659-673. Epub 2017 Nov 13.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-0352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796860PMC
February 2018

Therapeutic Implications of the Genetic Landscape of Head and Neck Cancer.

Semin Radiat Oncol 2018 01;28(1):2-11

Department of Otolaryngology-Head and Neck Surgery, University of California at San Francisco, San Francisco, CA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10534296173008
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http://dx.doi.org/10.1016/j.semradonc.2017.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293987PMC
January 2018

EGFR-targeted therapies in the post-genomic era.

Cancer Metastasis Rev 2017 09;36(3):463-473

Department of Otolaryngology, University of California San Francisco, 2380 Sutter Street, San Francisco, CA, 94113, USA.

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http://link.springer.com/10.1007/s10555-017-9687-8
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http://dx.doi.org/10.1007/s10555-017-9687-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693744PMC
September 2017

The fourth edition of the head and neck World Health Organization blue book: editors' perspectives.

Hum Pathol 2017 08 2;66:10-12. Epub 2017 Jun 2.

Department of Pathology HP437, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.humpath.2017.05.014DOI Listing
August 2017

Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines.

J Chem Biol 2017 Jul 11;10(3):129-141. Epub 2017 May 11.

Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA 94118 USA.

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http://dx.doi.org/10.1007/s12154-017-0169-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480263PMC
July 2017

Genomic and Transcriptomic Alterations Associated with STAT3 Activation in Head and Neck Cancer.

PLoS One 2016 17;11(11):e0166185. Epub 2016 Nov 17.

Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco, CA, United States of America, 94143.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166185PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113908PMC
June 2017

Head and neck cancer in 2016: A watershed year for improvements in treatment?

Nat Rev Clin Oncol 2017 Feb 6;14(2):76-78. Epub 2016 Dec 6.

Department of Otolaryngology-Head and Neck Surgery, Clinical and Translational Sciences Institute, University of California, San Francisco, 550 16th Street, Box 0558, San Francisco, California 94113, USA.

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http://dx.doi.org/10.1038/nrclinonc.2016.196DOI Listing
February 2017

Cancer genomics: Spot the difference.

Nature 2017 01 4;541(7636):162-163. Epub 2017 Jan 4.

Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1038/nature21112DOI Listing
January 2017

Toxicity, pharmacokinetics and metabolism of a novel inhibitor of IL-6-induced STAT3 activation.

Cancer Chemother Pharmacol 2016 Dec 24;78(6):1225-1235. Epub 2016 Oct 24.

Cancer Therapeutics Program, The University of Pittsburgh Cancer Institute, Hillman Cancer Center, Room G27e, 5117 Centre Ave, Pittsburgh, PA, 15213, USA.

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http://dx.doi.org/10.1007/s00280-016-3181-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115981PMC
December 2016

HPV-Associated Head and Neck Cancer: Unique Features of Epidemiology and Clinical Management.

Annu Rev Med 2016 26;67:91-101. Epub 2015 Aug 26.

Department of Otolaryngology, MedStar Georgetown University Hospital, Washington DC 20007; email:

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http://dx.doi.org/10.1146/annurev-med-051914-021907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242186PMC
October 2016

Treatment of head and neck cancer in the elderly.

Expert Opin Pharmacother 2016 Oct 16;17(14):1903-21. Epub 2016 Aug 16.

a Department of Otolaryngology , University of California San Francisco , San Francisco , CA , USA.

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http://dx.doi.org/10.1080/14656566.2016.1220540DOI Listing
October 2016

A sensible approach to targeting STAT3-mediated transcription.

Ann Transl Med 2016 Oct;4(Suppl 1):S57

Department of Otolaryngology, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.21037/atm.2016.10.51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104644PMC
October 2016

New Strategies in Esophageal Carcinoma: Translational Insights from Signaling Pathways and Immune Checkpoints.

Clin Cancer Res 2016 Sep 1;22(17):4283-90. Epub 2016 Jul 1.

Division of Hematology and Oncology, University of California San Francisco, San Francisco, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0292DOI Listing
September 2016

HGF/Met Signaling in Head and Neck Cancer: Impact on the Tumor Microenvironment.

Clin Cancer Res 2016 Aug 1;22(16):4005-13. Epub 2016 Jul 1.

Department of Otolaryngology, University of California San Francisco, San Francisco, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820346PMC
August 2016

Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors.

Bioorg Med Chem Lett 2016 08 9;26(15):3581-5. Epub 2016 Jun 9.

University of Pittsburgh Chemical Diversity Center, University of Pittsburgh, Pittsburgh, PA 15260, USA; Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1016/j.bmcl.2016.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964800PMC
August 2016

Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane.

Cancer Prev Res (Phila) 2016 Jul 23;9(7):547-57. Epub 2016 Jun 23.

Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1158/1940-6207.CAPR-15-0290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930727PMC
July 2016

Corrigendum to "Cetuximab activity in dysplastic lesions of the upper aerodigestive tract" [Oral Oncol. 53 (2016) 60-66].

Oral Oncol 2016 Jun 13;57:e8. Epub 2016 Apr 13.

Department of Otolaryngology-Head and Neck Surgery, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA; Milton J Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2016.03.018DOI Listing
June 2016

Loss-of-Function PTPRD Mutations Lead to Increased STAT3 Activation and Sensitivity to STAT3 Inhibition in Head and Neck Cancer.

PLoS One 2015 12;10(8):e0135750. Epub 2015 Aug 12.

Department of Otolaryngology, University of California San Francisco, San Francisco, CA, United States of America, 94143.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135750PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534317PMC
May 2016

The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations.

Oral Oncol 2016 May 28;56:84-92. Epub 2015 Dec 28.

Department of Internal Medicine, Division of Hematology/Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2015.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590227PMC
May 2016

MAPK1E322K mutation increases head and neck squamous cell carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin.

Oncotarget 2016 Apr;7(17):23300-11

Department of Otolaryngology Head and Neck Surgery, University of California at San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.18632/oncotarget.8188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029627PMC
April 2016

Proteomic Characterization of Head and Neck Cancer Patient-Derived Xenografts.

Mol Cancer Res 2016 Mar 18;14(3):278-86. Epub 2015 Dec 18.

Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania. Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania. Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco, California.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794346PMC
March 2016

Cetuximab activity in dysplastic lesions of the upper aerodigestive tract.

Oral Oncol 2016 Feb 10;53:60-6. Epub 2015 Dec 10.

Department of Otolaryngology-Head and Neck Surgery, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA; Milton J Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2015.11.016DOI Listing
February 2016

Treatment of Triple-Negative Breast Cancer with TORC1/2 Inhibitors Sustains a Drug-Resistant and Notch-Dependent Cancer Stem Cell Population.

Cancer Res 2016 Jan 16;76(2):440-52. Epub 2015 Dec 16.

Department of Medicine, Vanderbilt University, Nashville, Tennessee. Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee. Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1640-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715956PMC
January 2016

Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery.

PLoS One 2014 18;9(7):e102678. Epub 2014 Jul 18.

Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Computational & Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102678PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103836PMC
November 2015

MicroRNA-363 targets myosin 1B to reduce cellular migration in head and neck cancer.

BMC Cancer 2015 Nov 6;15:861. Epub 2015 Nov 6.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA.

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http://dx.doi.org/10.1186/s12885-015-1888-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635687PMC
November 2015

HCS campaign to identify selective inhibitors of IL-6-induced STAT3 pathway activation in head and neck cancer cell lines.

Assay Drug Dev Technol 2015 Sep;13(7):356-76

9 Clinical and Translational Science Institute, Otolaryngology - Head and Neck Surgery, University of California , San Francisco, California.

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http://dx.doi.org/10.1089/adt.2015.663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556090PMC
September 2015

Genetic mutations in head and neck cancer: utilizing existing treatments.

Pharmacogenomics 2014 ;15(12):1553-5

Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.2217/pgs.14.122DOI Listing
June 2015

Emerging drugs for head and neck cancer.

Expert Opin Emerg Drugs 2015 Jun 31;20(2):313-29. Epub 2015 Mar 31.

Sun Yat-Sen University and The First Affiliated Hospital of Sun Yat-Sen University, Department of Otolaryngology , Guangzhou, Guangzhou , PR China.

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http://dx.doi.org/10.1517/14728214.2015.1031653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678969PMC
June 2015

Therapeutic insights from genomic studies of head and neck squamous cell carcinomas.

Cancer Discov 2015 Mar 2;5(3):239-44. Epub 2015 Feb 2.

Department of Otolaryngology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania. Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1158/2159-8290.CD-14-1205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355279PMC
March 2015

Challenges in EGFRvIII detection in head and neck squamous cell carcinoma.

PLoS One 2015 6;10(2):e0117781. Epub 2015 Feb 6.

Department of Pathology, University of Pittsburgh, Pittsburgh, PA, United States of America; Department of Otolaryngology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States of America; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States of America; Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117781PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320077PMC
March 2015

JAK kinase inhibition abrogates STAT3 activation and head and neck squamous cell carcinoma tumor growth.

Neoplasia 2015 Mar;17(3):256-64

Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2015.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372647PMC
March 2015

Receptor-type protein tyrosine phosphatases in cancer.

Chin J Cancer 2015 Feb 17;34(2):61-9. Epub 2014 Oct 17.

Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.5732/cjc.014.10146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360074PMC
February 2015

HER2 as a therapeutic target in head and neck squamous cell carcinoma.

Clin Cancer Res 2015 Feb 25;21(3):526-33. Epub 2014 Nov 25.

Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315724PMC
February 2015

Identification of epidermal growth factor receptor (EGFR) genetic variants that modify risk for head and neck squamous cell carcinoma.

Cancer Lett 2015 Feb 12;357(2):549-56. Epub 2014 Dec 12.

Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2014.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295492PMC
February 2015

2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway.

Bioorg Med Chem Lett 2014 Nov 15;24(21):5081-5. Epub 2014 Sep 15.

University of Pittsburgh Chemical Diversity Center, University of Pittsburgh, Pittsburgh, PA 15260, USA; Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250329PMC
November 2014

High-content pSTAT3/1 imaging assays to screen for selective inhibitors of STAT3 pathway activation in head and neck cancer cell lines.

Assay Drug Dev Technol 2014 Jan-Feb;12(1):55-79. Epub 2013 Oct 15.

1 Department of Pharmaceutical Sciences, University of Pittsburgh , Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1089/adt.2013.524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934522PMC
October 2014

Identification of mutations in the PYRIN-containing NLR genes (NLRP) in Head and Neck Squamous Cell Carcinoma.

PLoS One 2014 21;9(1):e85619. Epub 2014 Jan 21.

Department of Otolaryngology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America ; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085619PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897487PMC
October 2014

Caspase-8 mutations in head and neck cancer confer resistance to death receptor-mediated apoptosis and enhance migration, invasion, and tumor growth.

Mol Oncol 2014 Oct 18;8(7):1220-30. Epub 2014 Apr 18.

Department of Medicine, University of Pittsburgh, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA; Department of Pharmacology & Chemical Biology, University of Pittsburgh, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA. Electronic address:

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http://doi.wiley.com/10.1016/j.molonc.2014.03.018
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http://dx.doi.org/10.1016/j.molonc.2014.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198498PMC
October 2014

STAT3 oligonucleotide inhibits tumor angiogenesis in preclinical models of squamous cell carcinoma.

PLoS One 2014 3;9(1):e81819. Epub 2014 Jan 3.

Department of Otolaryngology, School of Medicine, University of Pittsburgh, Pennsylvania, United States of America ; Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081819PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880270PMC
September 2014

Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss.

Nat Genet 2014 Sep 3;46(9):939-43. Epub 2014 Aug 3.

1] Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, California, USA. [2] Department of Medicine, University of California, San Diego, La Jolla, California, USA. [3] Department of Computer Science and Engineering, University of California, San Diego, La Jolla, California, USA. [4] Moores Cancer Center, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1038/ng.3051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146706PMC
September 2014

Erlotinib, erlotinib-sulindac versus placebo: a randomized, double-blind, placebo-controlled window trial in operable head and neck cancer.

Clin Cancer Res 2014 Jun 11;20(12):3289-98. Epub 2014 Apr 11.

Authors' Affiliations: Division of Head and Neck Surgery, Department of Otolaryngology, Oregon Health and Science University, Portland, Oregon; Division of Hematology/Oncology, Department of Internal Medicine; Department of Pharmacology and Chemical Biology;Biostatistics Facility, University of Pittsburgh, University of Pittsburgh Cancer Institute; Departments of Otolaryngology and Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Otolaryngology, University of Kansas Medical Center, Kansas City, Kansas; Women's Health Integrated Research Center, Gynecologic Cancer Center of Excellence, Annandale, Virginia; Division of Hematology/Oncology, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts; and Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-13-3360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104657PMC
June 2014

Integration of molecular targeted therapy with radiation in head and neck cancer.

Pharmacol Ther 2014 Apr 23;142(1):88-98. Epub 2013 Nov 23.

Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01637258130022
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http://dx.doi.org/10.1016/j.pharmthera.2013.11.007DOI Listing
April 2014

Epidemiology of head and neck squamous cell cancer among HIV-infected patients.

J Acquir Immune Defic Syndr 2014 Apr;65(5):603-10

*Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; †Department of Otolaryngology/Head and Neck Surgery, University of Michigan, Ann Arbor, MI; ‡Department of Head and Neck Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX; §Department of Internal Medicine, Emory University School of Medicine, Atlanta, GA; ‖Department of Radiation Oncology, Mount Sinai Medical Center, New York, NY; ¶Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI; #Department of Otolaryngology/Head and Neck Surgery, Johns Hopkins University, Baltimore, MD; **Cancer Biology Program, University of Michigan, Ann Arbor, MI; ††Department of Biostatistics, University of Texas M. D. Anderson Cancer Center, Houston, TX; §§Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA; and ‖‖Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

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http://dx.doi.org/10.1097/QAI.0000000000000083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999230PMC
April 2014

Systemic administration of a cyclic signal transducer and activator of transcription 3 (STAT3) decoy oligonucleotide inhibits tumor growth without inducing toxicological effects.

Mol Med 2014 Mar 18;20:46-56. Epub 2014 Mar 18.

Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.

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http://dx.doi.org/10.2119/molmed.2013.00104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951464PMC
March 2014

Single-agent obatoclax (GX15-070) potently induces apoptosis and pro-survival autophagy in head and neck squamous cell carcinoma cells.

Oral Oncol 2014 Feb 8;50(2):120-7. Epub 2013 Nov 8.

Department of Medicine, University of Pittsburgh, University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States; Department of Pharmacology & Chemical Biology, University of Pittsburgh, University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2013.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944051PMC
February 2014

Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer.

Proc Natl Acad Sci U S A 2014 Jan 6;111(3):1114-9. Epub 2014 Jan 6.

Departments of Otolaryngology, Pharmacology and Chemical Biology, Structural Biology, and Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.

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http://dx.doi.org/10.1073/pnas.1319551111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903220PMC
January 2014

Expression of EGFR, VEGF, and NOTCH1 suggest differences in tumor angiogenesis in HPV-positive and HPV-negative head and neck squamous cell carcinoma.

Head Neck Pathol 2013 Dec 4;7(4):344-55. Epub 2013 May 4.

Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, A516 Crabtree Hall, 130 DeSoto Street, Pittsburgh, PA, 15261, USA,

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http://dx.doi.org/10.1007/s12105-013-0447-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824798PMC
December 2013

Polymorphisms in NAT2 and GSTP1 are associated with survival in oral and oropharyngeal cancer.

Cancer Epidemiol 2013 Aug 21;37(4):505-11. Epub 2013 Mar 21.

Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15232, USA.

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http://dx.doi.org/10.1016/j.canep.2013.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690299PMC
August 2013

Childhood passive smoke exposure is associated with adult head and neck cancer.

Cancer Epidemiol 2013 Aug 22;37(4):417-23. Epub 2013 Apr 22.

Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15232, USA.

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http://dx.doi.org/10.1016/j.canep.2013.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706460PMC
August 2013

Critical analysis of the potential for targeting STAT3 in human malignancy.

Onco Targets Ther 2013 30;6:999-1010. Epub 2013 Jul 30.

Departments of Otolaryngology and Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.2147/OTT.S47903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735336PMC
August 2013

Cisplatin-Based Chemotherapy Options for Recurrent and/or Metastatic Squamous Cell Cancer of the Head and Neck.

Clin Med Insights Ther 2013 ;2013(5)

University of Pittsburgh, Department of Otolaryngology, Eye and Ear Institute, Pittsburgh, PA.

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http://dx.doi.org/10.4137/CMT.S10409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835153PMC
January 2013

Nucleic acid-based approaches to STAT inhibition.

JAKSTAT 2012 Oct;1(4):285-91

Department of Otolaryngology; University of Pittsburgh School of Medicine; Pittsburgh, PA USA.

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http://dx.doi.org/10.4161/jkst.22312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670286PMC
October 2012