Jennifer P Morton

Jennifer P Morton

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Jennifer P Morton

Jennifer P Morton

Publications by authors named "Jennifer P Morton"

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Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition.

Cell Rep 2020 Feb;30(8):2729-2742.e4

Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.01.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043007PMC
February 2020

CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer.

Trends Cancer 2019 Nov 21;5(11):724-741. Epub 2019 Oct 21.

The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia; St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales 2010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2019.09.010DOI Listing
November 2019

Neutrophils: Homing in on the myeloid mechanisms of metastasis.

Mol Immunol 2019 06;110:69-76

Cancer Research UK Beatson Institute, Garscube Estate, Switchback Rd, Glasgow G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2017.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544568PMC
June 2019

Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.

Cell Metab 2019 06 28;29(6):1390-1399.e6. Epub 2019 Feb 28.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602533PMC
June 2019

Combating pancreatic cancer with PI3K pathway inhibitors in the era of personalised medicine.

Gut 2019 04 5;68(4):742-758. Epub 2018 Nov 5.

Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Cancer Division, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1136/gutjnl-2018-316822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580874PMC
April 2019

Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer.

Gastroenterology 2018 03 26;154(4):820-838. Epub 2017 Dec 26.

The Garvan Institute of Medical Research, Sydney, New South Wales, Australia; The Kinghorn Cancer Center, Sydney, New South Wales, Australia; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.11.280DOI Listing
March 2018

PTEN deficiency permits the formation of pancreatic cancer in the absence of autophagy.

Cell Death Differ 2017 07 20;24(7):1303-1304. Epub 2017 Jan 20.

Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/cdd.2016.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520160PMC
July 2017

Substrate Rigidity Controls Activation and Durotaxis in Pancreatic Stellate Cells.

Sci Rep 2017 05 31;7(1):2506. Epub 2017 May 31.

Cellular and Molecular Biomechanics Laboratory, Department of Bioengineering, Imperial College London, London, SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1038/s41598-017-02689-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451433PMC
May 2017

Hypermutation In Pancreatic Cancer.

Gastroenterology 2017 01 15;152(1):68-74.e2. Epub 2016 Nov 15.

Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom; Department of Surgery, Bankstown Hospital, Bankstown, Sydney, New South Wales, Australia; South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales Australia, Liverpool, New South Wales, Australia; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085163518
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http://dx.doi.org/10.1053/j.gastro.2016.09.060DOI Listing
January 2017

CXCR2 inhibition in pancreatic cancer: opportunities for immunotherapy?

Immunotherapy 2017 01;9(1):9-12

Cancer Research UK Beatson Institute, Switchback Rd, Glasgow, G61 1BD, UK.

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http://dx.doi.org/10.2217/imt-2016-0115DOI Listing
January 2017

Notch3 drives development and progression of cholangiocarcinoma.

Proc Natl Acad Sci U S A 2016 10 10;113(43):12250-12255. Epub 2016 Oct 10.

Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, United Kingdom; The Scottish Liver Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, United Kingdom

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http://dx.doi.org/10.1073/pnas.1600067113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086988PMC
October 2016

Genomic analyses identify molecular subtypes of pancreatic cancer.

Authors:
Peter Bailey David K Chang Katia Nones Amber L Johns Ann-Marie Patch Marie-Claude Gingras David K Miller Angelika N Christ Tim J C Bruxner Michael C Quinn Craig Nourse L Charles Murtaugh Ivon Harliwong Senel Idrisoglu Suzanne Manning Ehsan Nourbakhsh Shivangi Wani Lynn Fink Oliver Holmes Venessa Chin Matthew J Anderson Stephen Kazakoff Conrad Leonard Felicity Newell Nick Waddell Scott Wood Qinying Xu Peter J Wilson Nicole Cloonan Karin S Kassahn Darrin Taylor Kelly Quek Alan Robertson Lorena Pantano Laura Mincarelli Luis N Sanchez Lisa Evers Jianmin Wu Mark Pinese Mark J Cowley Marc D Jones Emily K Colvin Adnan M Nagrial Emily S Humphrey Lorraine A Chantrill Amanda Mawson Jeremy Humphris Angela Chou Marina Pajic Christopher J Scarlett Andreia V Pinho Marc Giry-Laterriere Ilse Rooman Jaswinder S Samra James G Kench Jessica A Lovell Neil D Merrett Christopher W Toon Krishna Epari Nam Q Nguyen Andrew Barbour Nikolajs Zeps Kim Moran-Jones Nigel B Jamieson Janet S Graham Fraser Duthie Karin Oien Jane Hair Robert Grützmann Anirban Maitra Christine A Iacobuzio-Donahue Christopher L Wolfgang Richard A Morgan Rita T Lawlor Vincenzo Corbo Claudio Bassi Borislav Rusev Paola Capelli Roberto Salvia Giampaolo Tortora Debabrata Mukhopadhyay Gloria M Petersen Donna M Munzy William E Fisher Saadia A Karim James R Eshleman Ralph H Hruban Christian Pilarsky Jennifer P Morton Owen J Sansom Aldo Scarpa Elizabeth A Musgrove Ulla-Maja Hagbo Bailey Oliver Hofmann Robert L Sutherland David A Wheeler Anthony J Gill Richard A Gibbs John V Pearson Nicola Waddell Andrew V Biankin Sean M Grimmond

Nature 2016 Mar 24;531(7592):47-52. Epub 2016 Feb 24.

Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.

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http://dx.doi.org/10.1038/nature16965DOI Listing
March 2016

GEMMs as preclinical models for testing pancreatic cancer therapies.

Dis Model Mech 2015 Oct;8(10):1185-200

Cancer Research UK Beatson Institute, Glasgow, G61 1BD, UK

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http://dx.doi.org/10.1242/dmm.021055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610236PMC
October 2015

Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment.

Carcinogenesis 2014 Aug 5;35(8):1671-9. Epub 2014 Jun 5.

Cancer Division, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, NSW 2010, Sydney, Australia, Diabetes and Obesity Division, Garvan Institute of Medical Research, St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, NSW 2010, Sydney, Australia and The Beatson Institute for Cancer Research, Garscube Estate, Glasgow G61 1BD, UK

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http://dx.doi.org/10.1093/carcin/bgu108DOI Listing
August 2014

Expression of KOC, S100P, mesothelin and MUC1 in pancreatico-biliary adenocarcinomas: development and utility of a potential diagnostic immunohistochemistry panel.

BMC Clin Pathol 2014 23;14:35. Epub 2014 Jul 23.

Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden G61 1QH, UK ; Department of Pathology, Southern General Hospital, Greater Glasgow & Clyde NHS, Glasgow G51 4TF, UK.

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http://bmcclinpathol.biomedcentral.com/articles/10.1186/1472
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http://dx.doi.org/10.1186/1472-6890-14-35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112611PMC
July 2014

Dasatinib inhibits mammary tumour development in a genetically engineered mouse model.

J Pathol 2013 Aug;230(4):430-40

Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1002/path.4202DOI Listing
August 2013

Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer.

Cancer Res 2013 Aug 7;73(15):4674-86. Epub 2013 Jun 7.

The Beatson Institute for Cancer Research, Glasgow; Section of Dermatology, School of Medicine, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-4545DOI Listing
August 2013

Activation of the IL-6R/Jak/stat pathway is associated with a poor outcome in resected pancreatic ductal adenocarcinoma.

J Gastrointest Surg 2013 May 23;17(5):887-98. Epub 2013 Feb 23.

West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, G31 2ER, UK.

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http://dx.doi.org/10.1007/s11605-013-2168-7DOI Listing
May 2013

MYC-y mice: from tumour initiation to therapeutic targeting of endogenous MYC.

Mol Oncol 2013 Apr 8;7(2):248-58. Epub 2013 Mar 8.

Beatson Institute for Cancer Research, Garscube Estate, Switchback Rd, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1016/j.molonc.2013.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528411PMC
April 2013

The right time, the right place: will targeting human cancer-associated mutations to the mouse provide the perfect preclinical model?

Curr Opin Genet Dev 2012 Feb 7;22(1):28-35. Epub 2012 Mar 7.

The Beatson Institute for Cancer Research, Switchback Road, Glasgow, G61 1BD, UK.

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http://dx.doi.org/10.1016/j.gde.2012.02.009DOI Listing
February 2012

MicroRNA molecular profiles associated with diagnosis, clinicopathologic criteria, and overall survival in patients with resectable pancreatic ductal adenocarcinoma.

Clin Cancer Res 2012 Jan 23;18(2):534-45. Epub 2011 Nov 23.

West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, G31 2ER, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-0679DOI Listing
January 2012

Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling.

Nat Cell Biol 2011 Dec 4;14(1):51-60. Epub 2011 Dec 4.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XR, UK.

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http://dx.doi.org/10.1038/ncb2386DOI Listing
December 2011

Ras, PI3K/Akt and senescence: Paradoxes provide clues for pancreatic cancer therapy.

Small GTPases 2011 Sep 1;2(5):264-267. Epub 2011 Sep 1.

Drexel University College of Medicine; Philadelphia, PA USA.

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http://dx.doi.org/10.4161/sgtp.2.5.17367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265817PMC
September 2011

Timing is everything: Brca2 and p53 mutations in pancreatic cancer.

Gastroenterology 2011 Apr 23;140(4):1143-6. Epub 2011 Feb 23.

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http://dx.doi.org/10.1053/j.gastro.2011.02.026DOI Listing
April 2011

p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma.

J Pathol 2010 Oct;222(2):129-37

Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.

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http://dx.doi.org/10.1002/path.2748DOI Listing
October 2010

Trp53 deletion stimulates the formation of metastatic pancreatic tumors.

Am J Pathol 2008 Apr 29;172(4):1081-7. Epub 2008 Feb 29.

University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.

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http://dx.doi.org/10.2353/ajpath.2008.070778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276406PMC
April 2008

Shh signaling and pancreatic cancer: implications for therapy?

Cell Cycle 2007 Jul 18;6(13):1553-7. Epub 2007 May 18.

Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.4161/cc.6.13.4467DOI Listing
July 2007

RNA polymerase III transcription is repressed in response to the tumour suppressor ARF.

Nucleic Acids Res 2007 16;35(9):3046-52. Epub 2007 Apr 16.

Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, UK.

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http://dx.doi.org/10.1093/nar/gkm208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888803PMC
June 2007

Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis.

Proc Natl Acad Sci U S A 2007 Mar 19;104(12):5103-8. Epub 2007 Mar 19.

Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1073/pnas.0701158104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828712PMC
March 2007

p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB.

EMBO J 2003 Jun;22(11):2810-20

Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, Davidson Building, University of Glasgow, Glasgow G12 8QQ, UK.

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http://dx.doi.org/10.1093/emboj/cdg265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC156762PMC
June 2003

CK2 forms a stable complex with TFIIIB and activates RNA polymerase III transcription in human cells.

Mol Cell Biol 2002 Jun;22(11):3757-68

Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC133823PMC
http://dx.doi.org/10.1128/mcb.22.11.3757-3768.2002DOI Listing
June 2002