Publications by authors named "Jennifer L Meagher"

32Publications

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.

Cancer Cell 2019 11;36(5):498-511.e17

Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880868PMC
November 2019

Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2).

ACS Chem Biol 2016 12 31;11(12):3374-3382. Epub 2016 Oct 31.

Program in Chemical Biology, ‡Department of Chemistry, §Department of Biophysics, and ∥Life Sciences Institute, University of Michigan , 930 N. University Ave., Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1021/acschembio.6b00720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359770PMC
December 2016

High-resolution crystal structures of Colocasia esculenta tarin lectin.

Glycobiology 2017 01 24;27(1):50-56. Epub 2016 Aug 24.

Department of Biological Chemistry, University of Michigan, 1150 W. Medical Center Drive, Ann Arbor, MI 48109, USA

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http://dx.doi.org/10.1093/glycob/cww083DOI Listing
January 2017

Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors.

J Med Chem 2015 Jun 16;58(12):4927-39. Epub 2015 Jun 16.

†Departments of Medicinal Chemistry, ‡Internal Medicine, §Pharmacology, and ∥Biological Chemistry, ⊥Life Sciences Institute, and #Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474678PMC
June 2015

Structural analysis and binding properties of isoforms of tarin, the GNA-related lectin from Colocasia esculenta.

Biochim Biophys Acta 2015 Jan 23;1854(1):20-30. Epub 2014 Oct 23.

Instituto de Química, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-909, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2014.10.013DOI Listing
January 2015

Ordering a dynamic protein via a small-molecule stabilizer.

J Am Chem Soc 2013 Mar 22;135(9):3363-6. Epub 2013 Feb 22.

Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1021/ja3122334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607081PMC
March 2013

Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression.

J Med Chem 2012 Oct 2;55(19):8502-14. Epub 2012 Oct 2.

Comprehensive Cancer Center, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0934, USA.

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http://dx.doi.org/10.1021/jm3010306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495162PMC
October 2012

Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity.

J Med Chem 2012 Jul 2;55(13):6149-61. Epub 2012 Jul 2.

Comprehensive Cancer Center and Departments of Internal Medicine, Pharmacology and Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109-0934, USA.

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http://dx.doi.org/10.1021/jm300608wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417242PMC
July 2012

Design of Bcl-2 and Bcl-xL inhibitors with subnanomolar binding affinities based upon a new scaffold.

J Med Chem 2012 May 10;55(10):4664-82. Epub 2012 May 10.

Comprehensive Cancer Center and Department of Internal Medicine, University of Michigan , 1500 East Medical Center Drive, Ann Arbor, Michigan 48109-0934, United States.

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http://pubs.acs.org/doi/10.1021/jm300178u
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http://dx.doi.org/10.1021/jm300178uDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397176PMC
May 2012

Structural basis for the enhanced stability of highly fluorinated proteins.

Proc Natl Acad Sci U S A 2012 Mar 12;109(13):4810-5. Epub 2012 Mar 12.

Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1073/pnas.1120112109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324029PMC
March 2012

Interaction of a cyclic, bivalent smac mimetic with the x-linked inhibitor of apoptosis protein.

Biochemistry 2008 Sep 22;47(37):9811-24. Epub 2008 Aug 22.

Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1021/bi800785yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784912PMC
September 2008

Crystal structure of banana lectin reveals a novel second sugar binding site.

Glycobiology 2005 Oct 8;15(10):1033-42. Epub 2005 Jun 8.

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1093/glycob/cwi088DOI Listing
October 2005