Jennifer Keiser

Jennifer Keiser

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Jennifer Keiser

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Pharmacokinetics of ascending doses of ivermectin in Trichuris trichiura-infected children aged 2-12 years.

J Antimicrob Chemother 2019 Jun;74(6):1642-1647

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.

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http://dx.doi.org/10.1093/jac/dkz083DOI Listing
June 2019

Evaluation of emodepside in laboratory models of human intestinal nematode and schistosome infections.

Parasit Vectors 2019 May 14;12(1):226. Epub 2019 May 14.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.

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http://dx.doi.org/10.1186/s13071-019-3476-xDOI Listing
May 2019

Pharmacokinetics of Albendazole, Albendazole Sulfoxide, and Albendazole Sulfone Determined from Plasma, Blood, Dried-Blood Spots, and Mitra Samples of Hookworm-Infected Adolescents.

Antimicrob Agents Chemother 2019 Apr 27;63(4). Epub 2019 Mar 27.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland

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http://dx.doi.org/10.1128/AAC.02489-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437472PMC
April 2019

Novel 1-Methyl-1 H-pyrazole-5-carboxamide Derivatives with Potent Anthelmintic Activity.

J Med Chem 2019 Apr 28;62(7):3367-3380. Epub 2019 Mar 28.

School of Pharmaceutical Sciences , Nanjing Tech University , No. 30 South Puzhu Road , Nanjing 211816 , P. R. China.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01790DOI Listing
April 2019

Community-wide soil-transmitted helminth treatment is equity-effective.

Lancet 2019 Apr 18. Epub 2019 Apr 18.

Swiss Tropical and Public Health Institute, Basel CH-4002, Switzerland; University of Basel, Basel, Switzerland.

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https://linkinghub.elsevier.com/retrieve/pii/S01406736183298
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http://dx.doi.org/10.1016/S0140-6736(18)32981-7DOI Listing
April 2019

Life cycle maintenance and drug-sensitivity assays for early drug discovery in Schistosoma mansoni.

Nat Protoc 2019 02;14(2):461-481

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.

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http://dx.doi.org/10.1038/s41596-018-0101-yDOI Listing
February 2019

and Drug-Drug Interaction Study of the Effects of Ivermectin and Oxantel Pamoate on Tribendimidine.

Antimicrob Agents Chemother 2019 Jan 21;63(1). Epub 2018 Dec 21.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland

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http://dx.doi.org/10.1128/AAC.00762-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325189PMC
January 2019

Early Antischistosomal Leads Identified from in Vitro and in Vivo Screening of the Medicines for Malaria Venture Pathogen Box.

ACS Infect Dis 2019 Jan 16;5(1):102-110. Epub 2018 Nov 16.

Department of Medical Parasitology and Infection Biology , Swiss Tropical and Public Health Institute , Basel , Switzerland.

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http://pubs.acs.org/doi/10.1021/acsinfecdis.8b00220
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http://dx.doi.org/10.1021/acsinfecdis.8b00220DOI Listing
January 2019

Off-target effects of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel-pamoate, and albendazole plus oxantel-pamoate on the human gut microbiota.

Int J Parasitol Drugs Drug Resist 2018 12 2;8(3):372-378. Epub 2018 Jul 2.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.ijpddr.2018.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068340PMC
December 2018

SAR of a new antischistosomal urea carboxylic acid.

Bioorg Med Chem Lett 2018 Dec 25;28(23-24):3648-3651. Epub 2018 Oct 25.

College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.10.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301076PMC
December 2018

Impedance-Based Microfluidic Assay for Automated Antischistosomal Drug Screening.

ACS Sens 2018 Dec 28;3(12):2613-2620. Epub 2018 Nov 28.

Bio Engineering Laboratory, Dept. of Biosystems Science and Engineering , ETH Zurich , Basel , Switzerland.

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http://dx.doi.org/10.1021/acssensors.8b01027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396876PMC
December 2018

Assessment of tegumental damage to Schistosoma mansoni and S. haematobium after in vitro exposure to ferrocenyl, ruthenocenyl and benzyl derivatives of oxamniquine using scanning electron microscopy.

Parasit Vectors 2018 Nov 6;11(1):580. Epub 2018 Nov 6.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health institute, Socinstrasse 57, 4051, Basel, CH, Switzerland.

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-018-3132-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219169PMC
November 2018

Efficacy and safety of ascending dosages of tribendimidine against hookworm infections in children: a randomized controlled trial.

Clin Infect Dis 2018 Nov 29. Epub 2018 Nov 29.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.

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http://dx.doi.org/10.1093/cid/ciy999DOI Listing
November 2018

Synthesis, characterization and biological activity of organometallic derivatives of the antimalarial drug mefloquine as new antischistosomal drug candidates.

Medchemcomm 2018 Nov 10;9(11):1905-1909. Epub 2018 Oct 10.

Laboratory for Inorganic Chemical Biology , Chimie ParisTech , PSL University , F-75005 Paris , France . Email:

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http://dx.doi.org/10.1039/c8md00396cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256353PMC
November 2018

Acting beyond 2020: better characterization of praziquantel and promising antischistosomal leads.

Curr Opin Pharmacol 2018 10 1;42:27-33. Epub 2018 Aug 1.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, CH-4002 Basel, Switzerland; University of Basel, CH-4003 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2018.06.004DOI Listing
October 2018

Effects of Vancomycin and Ciprofloxacin on the NMRI Mouse Metabolism.

J Proteome Res 2018 10 20;17(10):3565-3573. Epub 2018 Sep 20.

Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Faculty of Medicine , Imperial College London , South Kensington Campus , London SW7 2AZ , United Kingdom.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.8b00583
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http://dx.doi.org/10.1021/acs.jproteome.8b00583DOI Listing
October 2018

Extrapolation of praziquantel pharmacokinetics to a pediatric population: a cautionary tale.

J Pharmacokinet Pharmacodyn 2018 Oct 14;45(5):747-762. Epub 2018 Sep 14.

Swiss Tropical and Public Health Institute, Socinstr. 57, CH-4002, Basel, Switzerland.

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http://dx.doi.org/10.1007/s10928-018-9601-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182730PMC
October 2018

Efficacy and Safety of Ivermectin Against Trichuris trichiura in Preschool-aged and School-aged Children: A Randomized Controlled Dose-finding Trial.

Clin Infect Dis 2018 Sep;67(8):1247-1255

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute.

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http://dx.doi.org/10.1093/cid/ciy246DOI Listing
September 2018

Pharmacokinetics of a Pediatric Tribendimidine Dose-Finding Study To Treat Hookworm Infection in African Children.

Antimicrob Agents Chemother 2018 Sep 27;62(9). Epub 2018 Aug 27.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland

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http://dx.doi.org/10.1128/AAC.00959-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125550PMC
September 2018

Drug Combinations Against Soil-Transmitted Helminth Infections.

Adv Parasitol 2019 7;103:91-115. Epub 2018 Sep 7.

Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1016/bs.apar.2018.08.002DOI Listing
September 2018

Efficacy and tolerability of moxidectin alone and in co-administration with albendazole and tribendimidine versus albendazole plus oxantel pamoate against Trichuris trichiura infections: a randomised, non-inferiority, single-blind trial.

Lancet Infect Dis 2018 08 29;18(8):864-873. Epub 2018 May 29.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(18)30233-0DOI Listing
August 2018

Pharmacokinetics of Praziquantel in Schistosoma mansoni- and Schistosoma haematobium-Infected School- and Preschool-Aged Children.

Antimicrob Agents Chemother 2018 Aug 27;62(8). Epub 2018 Jul 27.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland

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http://dx.doi.org/10.1128/AAC.02253-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105791PMC
August 2018

Preventive Chemotherapy in the Fight against Soil-Transmitted Helminthiasis: Achievements and Limitations.

Trends Parasitol 2018 07 29;34(7):590-602. Epub 2018 May 29.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.pt.2018.04.008DOI Listing
July 2018

A new soluble and bioactive polymorph of praziquantel.

Eur J Pharm Biopharm 2018 Jun 31;127:19-28. Epub 2018 Jan 31.

Department of Pharmacy and BioTechnology, University of Bologna, Via S. Donato 19/2, 40127 Bologna, Italy.

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http://dx.doi.org/10.1016/j.ejpb.2018.01.018DOI Listing
June 2018

Characterizing the Biochemical Response to Schistosoma mansoni Infection and Treatment with Praziquantel in Preschool and School Aged Children.

J Proteome Res 2018 06 21;17(6):2028-2033. Epub 2018 May 21.

Division of Integrative Systems Medicine and Digestive Diseases , Department of Surgery and Cancer, Imperial College London , London SW7 2AZ , United Kingdom.

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http://dx.doi.org/10.1021/acs.jproteome.7b00910DOI Listing
June 2018

Diagnostic comparison between FECPAKG2 and the Kato-Katz method for analyzing soil-transmitted helminth eggs in stool.

PLoS Negl Trop Dis 2018 06 4;12(6):e0006562. Epub 2018 Jun 4.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel Switzerland.

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http://dx.doi.org/10.1371/journal.pntd.0006562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002127PMC
June 2018

Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against Schistosoma mansoni.

Parasit Vectors 2018 05 15;11(1):298. Epub 2018 May 15.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, P.O. Box, CH-4002, Basel, Switzerland.

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-018-2855-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952519PMC
May 2018

Retrospective assessment of resource use and costs in two investigator-initiated randomized trials exemplified a comprehensive cost item list.

J Clin Epidemiol 2018 Apr 30;96:73-83. Epub 2017 Dec 30.

Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jclinepi.2017.12.022DOI Listing
April 2018

The optimal timing of post-treatment sampling for the assessment of anthelminthic drug efficacy against Ascaris infections in humans.

Int J Parasitol Drugs Drug Resist 2018 04 13;8(1):67-69. Epub 2018 Jan 13.

Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

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http://dx.doi.org/10.1016/j.ijpddr.2017.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114078PMC
April 2018

Egg Excretion does not Increase after Exercise: Implications for Diagnostic Testing.

Am J Trop Med Hyg 2018 03 14;98(3):772-775. Epub 2017 Dec 14.

Divisions of General Internal Medicine and Infectious Diseases, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.17-0728
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http://dx.doi.org/10.4269/ajtmh.17-0728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930907PMC
March 2018

Evaluation of a novel micro-sampling device, Mitra™, in comparison to dried blood spots, for analysis of praziquantel in Schistosoma haematobium-infected children in rural Côte d'Ivoire.

J Pharm Biomed Anal 2018 Mar 31;151:339-346. Epub 2018 Jan 31.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2018.01.030DOI Listing
March 2018

Investigations on the interplays between Schistosoma mansoni, praziquantel and the gut microbiome.

Parasit Vectors 2018 03 12;11(1):168. Epub 2018 Mar 12.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.

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http://dx.doi.org/10.1186/s13071-018-2739-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848565PMC
March 2018

Efficacy and safety of tribendimidine versus praziquantel against Opisthorchis viverrini in Laos: an open-label, randomised, non-inferiority, phase 2 trial.

Lancet Infect Dis 2018 02 16;18(2):155-161. Epub 2017 Nov 16.

Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1016/S1473-3099(17)30624-2DOI Listing
February 2018

Progress in antischistosomal N,N'-diaryl urea SAR.

Bioorg Med Chem Lett 2018 02 29;28(3):244-248. Epub 2017 Dec 29.

College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.12.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026081PMC
February 2018

Immunohistochemical Investigations of Treatment with Ro 13-3978, Praziquantel, Oxamniquine, and Mefloquine in Schistosoma mansoni-Infected Mice.

Antimicrob Agents Chemother 2017 12 22;61(12). Epub 2017 Nov 22.

Swiss Tropical and Public Health Institute, Basel, Switzerland, and University of Basel, Basel Switzerland

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http://dx.doi.org/10.1128/AAC.01142-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700362PMC
December 2017

An explorative analysis of process and formulation variables affecting comilling in a vibrational mill: The case of praziquantel.

Int J Pharm 2017 Nov 24;533(2):402-412. Epub 2017 May 24.

Department of Pharmacy and BioTechnology, University of Bologna, Via S. Donato 19/2, 40127 Bologna, Italy.

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http://dx.doi.org/10.1016/j.ijpharm.2017.05.053DOI Listing
November 2017

Ferrocenyl, Ruthenocenyl, and Benzyl Oxamniquine Derivatives with Cross-Species Activity against Schistosoma mansoni and Schistosoma haematobium.

ACS Infect Dis 2017 09 18;3(9):645-652. Epub 2017 Jul 18.

Chimie ParisTech, PSL Research University, Laboratory for Inorganic Chemical Biology , F-75005 Paris, France.

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http://dx.doi.org/10.1021/acsinfecdis.7b00054DOI Listing
September 2017

Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the Schistosoma mansoni mouse model.

PLoS Negl Trop Dis 2017 Sep 21;11(9):e0005942. Epub 2017 Sep 21.

Merck Global Health Institute, Ares Trading S.A., a subsidiary of Merck KGaA (Darmstadt, Germany), Coinsins, Switzerland.

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http://dx.doi.org/10.1371/journal.pntd.0005942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626502PMC
September 2017

Efficacy of recommended drugs against soil transmitted helminths: systematic review and network meta-analysis.

BMJ 2017 Sep 25;358:j4307. Epub 2017 Sep 25.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, PO Box, CH-4002 Basel, Switzerland

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611648PMC
http://dx.doi.org/10.1136/bmj.j4307DOI Listing
September 2017

Exposure of Heligmosomoides polygyrus and Trichuris muris to albendazole, albendazole sulfoxide, mebendazole and oxantel pamoate in vitro and in vivo to elucidate the pathway of drug entry into these gastrointestinal nematodes.

Int J Parasitol Drugs Drug Resist 2017 08 24;7(2):159-173. Epub 2017 Mar 24.

Department of Medical Parasitology and Infection Biology Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel, Switzerland; University of Basel, P.O. Box, CH-4003 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ijpddr.2017.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377441PMC
August 2017

In vitro and in vivo activity of R- and S- praziquantel enantiomers and the main human metabolite trans-4-hydroxy-praziquantel against Schistosoma haematobium.

Parasit Vectors 2017 Aug 1;10(1):365. Epub 2017 Aug 1.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.

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http://dx.doi.org/10.1186/s13071-017-2293-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540299PMC
August 2017

Excretory/secretory products from the gastrointestinal nematode Trichuris muris.

Exp Parasitol 2017 Jul 19;178:30-36. Epub 2017 May 19.

Institute of Parasitology, McGill University, 21,111 Lakeshore Road, Sainte-Anne-de-Bellevue, Quebec H9X 3V9, Canada; Centre for Host-Parasite Interactions, Canada.

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http://dx.doi.org/10.1016/j.exppara.2017.05.003DOI Listing
July 2017

Efficacy and safety of praziquantel in preschool-aged and school-aged children infected with Schistosoma mansoni: a randomised controlled, parallel-group, dose-ranging, phase 2 trial.

Lancet Glob Health 2017 07;5(7):e688-e698

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/S2214-109X(17)30187-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471607PMC
July 2017

Mobile-phone and handheld microscopy for neglected tropical diseases.

PLoS Negl Trop Dis 2017 07 6;11(7):e0005550. Epub 2017 Jul 6.

Department of Medicine, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1371/journal.pntd.0005550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499985PMC
July 2017

Controlling schistosomiasis with praziquantel: How much longer without a viable alternative?

Infect Dis Poverty 2017 Mar 28;6(1):74. Epub 2017 Mar 28.

Swiss Tropical and Public Health Institute, P.O. Box, CH-4002, Basel, Switzerland.

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http://dx.doi.org/10.1186/s40249-017-0286-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371198PMC
March 2017

Unexpected low soil-transmitted helminth prevalence in the Butha-Buthe district in Lesotho, results from a cross-sectional survey.

Parasit Vectors 2017 02 8;10(1):72. Epub 2017 Feb 8.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.

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http://dx.doi.org/10.1186/s13071-017-1995-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299746PMC
February 2017

Pharmacokinetics of the Antischistosomal Lead Ozonide OZ418 in Uninfected Mice Determined by Liquid Chromatography-Tandem Mass Spectrometry.

Antimicrob Agents Chemother 2016 12 21;60(12):7364-7371. Epub 2016 Nov 21.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland

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http://dx.doi.org/10.1128/AAC.02394-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119018PMC
December 2016

Comparison of sensitivity and faecal egg counts of Mini-FLOTAC using fixed stool samples and Kato-Katz technique for the diagnosis of Schistosoma mansoni and soil-transmitted helminths.

Acta Trop 2016 Dec 31;164:107-116. Epub 2016 Aug 31.

Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel, Switzerland; University of Basel, P.O. Box, CH-4003 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.actatropica.2016.08.024DOI Listing
December 2016

Revisiting the SAR of the Antischistosomal Aryl Hydantoin (Ro 13-3978).

J Med Chem 2016 12 28;59(23):10705-10718. Epub 2016 Nov 28.

College of Pharmacy, University of Nebraska Medical Center , 986125 Nebraska Medical Center, Omaha, Nebraska 68198, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150661PMC
December 2016

Approved oncology drugs lack in vivo activity against Trichuris muris despite in vitro activity.

Parasitol Res 2016 Nov 8;115(11):4443-4446. Epub 2016 Aug 8.

Swiss Tropical and Public Health Institute, P.O. Box CH-4002, Basel, Switzerland.

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http://dx.doi.org/10.1007/s00436-016-5225-9DOI Listing
November 2016

Population Pharmacokinetic Modeling of Tribendimidine Metabolites in Opisthorchis viverrini-Infected Adults.

Antimicrob Agents Chemother 2016 10 23;60(10):5695-704. Epub 2016 Sep 23.

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1128/AAC.00655-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038332PMC
October 2016

Single-Ascending-Dose Pharmacokinetic Study of Tribendimidine in Opisthorchis viverrini-Infected Patients.

Antimicrob Agents Chemother 2016 10 23;60(10):5705-15. Epub 2016 Sep 23.

Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland

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http://aac.asm.org/lookup/doi/10.1128/AAC.00992-16
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http://dx.doi.org/10.1128/AAC.00992-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038241PMC
October 2016

Efficacy and safety of tribendimidine against Opisthorchis viverrini: two randomised, parallel-group, single-blind, dose-ranging, phase 2 trials.

Lancet Infect Dis 2016 Oct 26;16(10):1145-1153. Epub 2016 Jul 26.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(16)30198-0DOI Listing
October 2016

In Vitro and In Vivo Drug Interaction Study of Two Lead Combinations, Oxantel Pamoate plus Albendazole and Albendazole plus Mebendazole, for the Treatment of Soil-Transmitted Helminthiasis.

Antimicrob Agents Chemother 2016 10 23;60(10):6127-33. Epub 2016 Sep 23.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland

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http://dx.doi.org/10.1128/AAC.01217-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038309PMC
October 2016

Evaluation of Malaria Diagnoses Using a Handheld Light Microscope in a Community-Based Setting in Rural Côte d'Ivoire.

Am J Trop Med Hyg 2016 10 15;95(4):831-834. Epub 2016 Aug 15.

Division of General Internal Medicine, Toronto General Hospital, Toronto, Canada. Division of Infectious Diseases, Toronto General Hospital, Toronto, Canada. Department of Medicine, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.4269/ajtmh.16-0328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062782PMC
October 2016

Re-infection with Fasciola gigantica 6-month post-treatment with triclabendazole in cattle from mobile pastoralist husbandry systems at Lake Chad.

Vet Parasitol 2016 Oct 23;230:43-48. Epub 2016 Oct 23.

Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.vetpar.2016.10.019DOI Listing
October 2016

Efficacy and Safety of Moxidectin, Synriam, Synriam-Praziquantel versus Praziquantel against Schistosoma haematobium and S. mansoni Infections: A Randomized, Exploratory Phase 2 Trial.

PLoS Negl Trop Dis 2016 09 16;10(9):e0005008. Epub 2016 Sep 16.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.

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http://dx.doi.org/10.1371/journal.pntd.0005008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026339PMC
September 2016

Evaluation of a Urine Pooling Strategy for the Rapid and Cost-Efficient Prevalence Classification of Schistosomiasis.

PLoS Negl Trop Dis 2016 08 9;10(8):e0004894. Epub 2016 Aug 9.

Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0004894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978437PMC
August 2016

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

Bimodal X-ray and Infrared Imaging of an Organometallic Derivative of Praziquantel in Schistosoma mansoni.

Chembiochem 2016 06 28;17(11):1004-7. Epub 2016 Apr 28.

École Normale Supérieure, PSL Research University, Département de Chimie, 24 rue Lhomond, 75005, Paris, France.

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http://dx.doi.org/10.1002/cbic.201500688DOI Listing
June 2016

Clonorchiasis.

Lancet 2016 Feb 21;387(10020):800-10. Epub 2015 Aug 21.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, China; World Health Organization Collaborating Center for Tropical Diseases, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(15)60313-0DOI Listing
February 2016

Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study.

Lancet Infect Dis 2016 Jan 18;16(1):53-60. Epub 2015 Sep 18.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, and University of Basel, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(15)00271-6DOI Listing
January 2016

Effect of sanitation and water treatment on intestinal protozoa infection: a systematic review and meta-analysis.

Lancet Infect Dis 2016 Jan 21;16(1):87-99. Epub 2015 Sep 21.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, and University of Basel, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(15)00349-7DOI Listing
January 2016

Development and validation of an enantioselective LC-MS/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in human plasma, blood and dried blood spots.

J Pharm Biomed Anal 2016 Jan 22;118:81-88. Epub 2015 Oct 22.

Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.jpba.2015.10.011DOI Listing
January 2016

A novel isothermal microcalorimetry tool to assess drug effects on Ancylostoma ceylanicum and Necator americanus.

Appl Microbiol Biotechnol 2016 Jan 30;100(2):837-46. Epub 2015 Oct 30.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, CH-4002, Basel, Switzerland.

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http://link.springer.com/content/pdf/10.1007%2Fs00253-015-70
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http://link.springer.com/10.1007/s00253-015-7081-4
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http://dx.doi.org/10.1007/s00253-015-7081-4DOI Listing
January 2016

Diagnosis of Opisthorchis viverrini Infection with Handheld Microscopy in Lao People's Democratic Republic.

Am J Trop Med Hyg 2016 Jan 2;94(1):158-60. Epub 2015 Nov 2.

Divisions of Internal Medicine and Infectious Diseases, University Health Network, Ontario, Canada; Department of Medicine, University of Toronto, Ontario, Canada; National Institute of Public Health, Ministry of Health, Vientiane, Lao People's Democratic Republic; Faculty of Medical Sciences, University of Health Sciences, Vientiane, Lao People's Democratic Republic; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute and University of Basel, Basel, Switzerland; University of Basel, Basel, Switzerland; Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute and University of Basel, Basel, Switzerland; Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California.

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http://dx.doi.org/10.4269/ajtmh.15-0525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710422PMC
January 2016

Fluorescence/luminescence-based markers for the assessment of Schistosoma mansoni schistosomula drug assays.

Parasit Vectors 2015 Dec 8;8:624. Epub 2015 Dec 8.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, CH-4002, Basel, Switzerland.

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http://dx.doi.org/10.1186/s13071-015-1233-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672532PMC
December 2015

Is Caenorhabditis elegans the Magic Bullet for Anthelminthic Drug Discovery?

Authors:
Jennifer Keiser

Trends Parasitol 2015 Oct 25;31(10):455-456. Epub 2015 Sep 25.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.pt.2015.08.004DOI Listing
October 2015