Jen-Chieh Chuang

Jen-Chieh Chuang

UNVERIFIED PROFILE

Are you Jen-Chieh Chuang?   Register this Author

Register author
Jen-Chieh Chuang

Jen-Chieh Chuang

Publications by authors named "Jen-Chieh Chuang"

Are you Jen-Chieh Chuang?   Register this Author

42Publications

778Reads

29Profile Views

SWI/SNF component restrains pancreatic neoplasia formation.

Gut 2019 07 12;68(7):1259-1270. Epub 2018 Oct 12.

Children's Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

View Article

Download full-text PDF

Source
http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2017-315490
Publisher Site
http://dx.doi.org/10.1136/gutjnl-2017-315490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499717PMC
July 2019

β1-adrenergic receptors mediate plasma acyl-ghrelin elevation and depressive-like behavior induced by chronic psychosocial stress.

Neuropsychopharmacology 2019 06 8;44(7):1319-1327. Epub 2019 Feb 8.

Department of Internal Medicine, Division of Hypothalamic Research, UT Southwestern Medical Center, 5323 Harry Hines Blvd., MC9077, Dallas, TX, 75390-9077, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41386-019-0334-7DOI Listing
June 2019

Arid1a Loss Drives Nonalcoholic Steatohepatitis in Mice Through Epigenetic Dysregulation of Hepatic Lipogenesis and Fatty Acid Oxidation.

Hepatology 2019 May 18;69(5):1931-1945. Epub 2019 Mar 18.

Children's Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.30487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461494PMC
May 2019

1,25-Dihydroxyvitamin D enhances glucose-stimulated insulin secretion in mouse and human islets: a role for transcriptional regulation of voltage-gated calcium channels by the vitamin D receptor.

J Steroid Biochem Mol Biol 2019 01 30;185:17-26. Epub 2018 Jul 30.

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, United States; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsbmb.2018.07.004DOI Listing
January 2019

Identification of Correlative Shifts in Indices of Brain Cholesterol Metabolism in the C57BL6/Mecp2 Mouse, a Model for Rett Syndrome.

Lipids 2018 04 17;53(4):363-373. Epub 2018 May 17.

Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9151, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lipd.12041DOI Listing
April 2018

Measurement of Rates of Cholesterol and Fatty Acid Synthesis In Vivo Using Tritiated Water.

Methods Mol Biol 2017 ;1583:241-256

Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-9151, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-6875-6_18DOI Listing
February 2018

Impact of loss of SOAT2 function on disease progression in the lysosomal acid lipase-deficient mouse.

Steroids 2018 02 13;130:7-14. Epub 2017 Dec 13.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.steroids.2017.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760480PMC
February 2018

Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer.

Cancer Cell 2017 11;32(5):574-589.e6

Children's Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2017.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728182PMC
November 2017

Quantitation of the rates of hepatic and intestinal cholesterol synthesis in lysosomal acid lipase-deficient mice before and during treatment with ezetimibe.

Biochem Pharmacol 2017 Jul 18;135:116-125. Epub 2017 Mar 18.

Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2017.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489310PMC
July 2017

Suppression of brain cholesterol synthesis in male Mecp2-deficient mice is age dependent and not accompanied by a concurrent change in the rate of fatty acid synthesis.

Brain Res 2017 Jan 24;1654(Pt A):77-84. Epub 2016 Oct 24.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brainres.2016.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131633PMC
January 2017

Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration.

Cell Stem Cell 2016 Apr 24;18(4):456-66. Epub 2016 Mar 24.

Departments of Pediatrics and Internal Medicine, Children's Research Institute, Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S19345909160010
Publisher Site
http://dx.doi.org/10.1016/j.stem.2016.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826298PMC
April 2016

PRD125, a potent and selective inhibitor of sterol O-acyltransferase 2 markedly reduces hepatic cholesteryl ester accumulation and improves liver function in lysosomal acid lipase-deficient mice.

J Pharmacol Exp Ther 2015 Nov 17;355(2):159-67. Epub 2015 Aug 17.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas (A.M.L., J-C.C., K.S.P., S.D.T.); Graduate School of Pharmaceutical Science, Kitasato University, Tokyo, Japan (T.O., H.T.); and Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina (T.O., L.L.R.)

View Article

Download full-text PDF

Source
http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.115.22720
Publisher Site
http://dx.doi.org/10.1124/jpet.115.227207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613965PMC
November 2015

Impact of physiological levels of chenodeoxycholic acid supplementation on intestinal and hepatic bile acid and cholesterol metabolism in Cyp7a1-deficient mice.

Steroids 2015 Jan 28;93:87-95. Epub 2014 Nov 28.

Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.steroids.2014.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297738PMC
January 2015

Impact of the loss of caveolin-1 on lung mass and cholesterol metabolism in mice with and without the lysosomal cholesterol transporter, Niemann-Pick type C1.

Biochim Biophys Acta 2014 Jul 18;1841(7):995-1002. Epub 2014 Apr 18.

Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13881981140007
Publisher Site
http://dx.doi.org/10.1016/j.bbalip.2014.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035115PMC
July 2014

Sustained and selective suppression of intestinal cholesterol synthesis by Ro 48-8071, an inhibitor of 2,3-oxidosqualene:lanosterol cyclase, in the BALB/c mouse.

Biochem Pharmacol 2014 Apr 31;88(3):351-63. Epub 2014 Jan 31.

Departments of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2014.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989900PMC
April 2014

Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin.

Mol Metab 2014 Feb 17;3(1):64-72. Epub 2013 Oct 17.

Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA ; Division of Endocrinology and Metabolism, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA ; Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmet.2013.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929914PMC
February 2014

Role of calcium and EPAC in norepinephrine-induced ghrelin secretion.

Endocrinology 2014 Jan 20;155(1):98-107. Epub 2013 Dec 20.

Division of Endocrinology and Metabolism (B.K.M., J.-C.C., I.S., A.K.W., A.K., S.O.-L., J.M.Z.), Department of Internal Medicine; Division of Hypothalamic research (B.K.M., J.-C.C., L.K., I.S., A.K.W., A.K., S.O.-L., J.J.R., J.M.Z.), Department of Internal Medicine; and Departments of Psychiatry (B.K.M., J.-C.C., I.S., A.K.W., A.K., S.O.-L., J.M.Z.) and Physiology (L.K., J.J.R.), University of Texas Southwestern Medical Center, Dallas, Texas 75390.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2013-1691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868802PMC
January 2014

Ezetimibe markedly attenuates hepatic cholesterol accumulation and improves liver function in the lysosomal acid lipase-deficient mouse, a model for cholesteryl ester storage disease.

Biochem Biophys Res Commun 2014 Jan 25;443(3):1073-7. Epub 2013 Dec 25.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9151, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2013.12.096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935496PMC
January 2014

Characterization of gastric and neuronal histaminergic populations using a transgenic mouse model.

PLoS One 2013 29;8(3):e60276. Epub 2013 Mar 29.

The Department of Internal Medicine (Division of Hypothalamic Research and Division of Endocrinology & Metabolism) and the Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060276PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612060PMC
September 2013

Differential effects of chronic social stress and fluoxetine on meal patterns in mice.

Appetite 2013 May 11;64:81-8. Epub 2013 Jan 11.

Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9070, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.appet.2012.12.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606634PMC
May 2013

Hindbrain ghrelin receptor signaling is sufficient to maintain fasting glucose.

PLoS One 2012 31;7(8):e44089. Epub 2012 Aug 31.

Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044089PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432098PMC
February 2013

Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells.

Am J Physiol Endocrinol Metab 2012 May 13;302(10):E1300-10. Epub 2012 Mar 13.

Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9077, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpendo.00041.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361986PMC
May 2012

Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice.

J Clin Invest 2012 Mar 13;122(3):1000-9. Epub 2012 Feb 13.

Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75390-9051, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI59816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287225PMC
March 2012

Functional implications of limited leptin receptor and ghrelin receptor coexpression in the brain.

J Comp Neurol 2012 Feb;520(2):281-94

Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cne.22690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282302PMC
February 2012

Ghrelin directly stimulates glucagon secretion from pancreatic alpha-cells.

Mol Endocrinol 2011 Sep 30;25(9):1600-11. Epub 2011 Jun 30.

Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9077, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/me.2011-1001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165914PMC
September 2011

Ghrelin's Roles in Stress, Mood, and Anxiety Regulation.

Int J Pept 2010 14;2010. Epub 2010 Feb 14.

Divisions of Hypothalamic Research and Endocrinology & Metabolism, Department of Internal Medicine, The University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9077, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2010/460549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915752PMC
July 2011

Ghrelin mediates stress-induced food-reward behavior in mice.

J Clin Invest 2011 Jul 23;121(7):2684-92. Epub 2011 Jun 23.

Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9077, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI57660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223843PMC
July 2011

5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver.

Nat Neurosci 2010 Dec 31;13(12):1457-9. Epub 2010 Oct 31.

Division of Hypothalamic Research and Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nn.2664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059249PMC
December 2010

Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice.

Proc Natl Acad Sci U S A 2010 Oct 20;107(40):17391-6. Epub 2010 Sep 20.

Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.1008025107
Publisher Site
http://dx.doi.org/10.1073/pnas.1008025107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951430PMC
October 2010

Translational neuroscience approaches to hyperphagia.

J Neurosci 2010 Sep;30(35):11549-54

Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9127, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.2578-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948492PMC
September 2010

Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner.

Biol Psychiatry 2010 May 24;67(9):880-6. Epub 2009 Dec 24.

Department of Internal Medicine (Division of Hypothalamic Research), The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9077, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biopsych.2009.10.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854245PMC
May 2010

Research resource: nuclear hormone receptor expression in the endocrine pancreas.

Mol Endocrinol 2008 Oct 31;22(10):2353-63. Epub 2008 Jul 31.

Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9077, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/mend/article-lookup/doi/10.1210/me.
Publisher Site
http://dx.doi.org/10.1210/me.2007-0568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582538PMC
October 2008

Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice.

Proc Natl Acad Sci U S A 2008 Mar 28;105(10):3992-7. Epub 2008 Feb 28.

Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology, and Research (ASTAR), Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0711700105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268794PMC
March 2008