Jen Jen Yeh

Jen Jen Yeh

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Jen Jen Yeh

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Impact of neoadjuvant therapy on postoperative outcomes after pancreaticoduodenectomy.

J Surg Oncol 2018 Sep 16;118(3):455-462. Epub 2018 Aug 16.

Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1002/jso.25183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653597PMC
September 2018

Use of iontophoresis for the treatment of cancer.

J Control Release 2018 08 15;284:144-151. Epub 2018 Jun 15.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA.

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http://dx.doi.org/10.1016/j.jconrel.2018.06.020DOI Listing
August 2018

Sequencing Pancreatic Juice: Squeezing the Most Out of Surveillance.

Clin Cancer Res 2018 06 2;24(12):2713-2715. Epub 2018 Mar 2.

Department of Pharmacology, School of Medicine, The University of North Carolina, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-0215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295911PMC
June 2018

Impact of formulation on the iontophoretic delivery of the FOLFIRINOX regimen for the treatment of pancreatic cancer.

Cancer Chemother Pharmacol 2018 06 30;81(6):991-998. Epub 2018 Mar 30.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1007/s00280-018-3570-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753584PMC
June 2018

Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability.

PLoS One 2017 5;12(4):e0174863. Epub 2017 Apr 5.

Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174863PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381904PMC
September 2017

Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer.

Oncotarget 2017 Aug 1;8(34):56081-56094. Epub 2016 Jun 1.

Curriculum in Genetics & Molecular Biology, The University of North Carolina, Chapel Hill, NC.

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http://dx.doi.org/10.18632/oncotarget.9760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593546PMC
August 2017

Outpatient Total Thyroidectomy Is Safe for Moderate-Volume Surgeons.

Am Surg 2017 Jul;83(7):750-754

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July 2017

Selective single cell isolation for genomics using microraft arrays.

Nucleic Acids Res 2016 09 16;44(17):8292-301. Epub 2016 Aug 16.

Curriculum in Bioinformatics and Computational Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA Department of Biology, Campus Box 3280, Coker Hall, UNC-Chapel Hill, Chapel Hill, NC 27599-3280, USA Department of Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041489PMC
http://dx.doi.org/10.1093/nar/gkw700DOI Listing
September 2016

Metformin Treatment Does Not Inhibit Growth of Pancreatic Cancer Patient-Derived Xenografts.

PLoS One 2016 13;11(1):e0147113. Epub 2016 Jan 13.

Department of Pharmacology, School of Medicine, The University of North Carolina, Chapel Hill, NC, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147113PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711922PMC
July 2016

Gut microbiome compositional and functional differences between tumor and non-tumor adjacent tissues from cohorts from the US and Spain.

Gut Microbes 2015 ;6(3):161-72

a Department of Cell Biology and Physiology, and Microbiome Core Facility; University of North Carolina School of Medicine ; Chapel Hill , NC , USA.

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http://dx.doi.org/10.1080/19490976.2015.1039223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615176PMC
February 2016

Iontophoretic device delivery for the localized treatment of pancreatic ductal adenocarcinoma.

Proc Natl Acad Sci U S A 2016 Feb 8;113(8):2200-5. Epub 2016 Feb 8.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Division of Surgical Oncology, Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

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http://dx.doi.org/10.1073/pnas.1600421113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776454PMC
February 2016

Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression.

Cancer Cell 2016 Jan 24;29(1):75-89. Epub 2015 Dec 24.

Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816652PMC
January 2016

mTOR inhibition induces compensatory, therapeutically targetable MEK activation in renal cell carcinoma.

PLoS One 2014 2;9(9):e104413. Epub 2014 Sep 2.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104413PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152178PMC
May 2015

Targeting tumor hypoxia with hypoxia-activated prodrugs.

J Clin Oncol 2015 May 23;33(13):1505-8. Epub 2015 Mar 23.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC

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http://dx.doi.org/10.1200/JCO.2014.60.0759DOI Listing
May 2015

Local iontophoretic administration of cytotoxic therapies to solid tumors.

Sci Transl Med 2015 Feb;7(273):273ra14

Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA.

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http://desimone-group.chem.unc.edu/wp-content/uploads/2015/0
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http://stm.sciencemag.org/cgi/doi/10.1126/scitranslmed.30099
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http://dx.doi.org/10.1126/scitranslmed.3009951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545246PMC
February 2015

Circulating tumor cells as a biomarker of response to treatment in patient-derived xenograft mouse models of pancreatic adenocarcinoma.

PLoS One 2014 19;9(2):e89474. Epub 2014 Feb 19.

University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America ; Department of Surgery, University of North Carolina, Chapel Hill, North Carolina, United States of America ; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America ; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089474PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929698PMC
October 2014

Value of intraoperative neck margin analysis during Whipple for pancreatic adenocarcinoma: a multicenter analysis of 1399 patients.

Ann Surg 2014 Sep;260(3):494-501; discussion 501-3

Departments of *Surgery †Pathology, and ‡Medical Oncology, Emory University School of Medicine, Atlanta, GA §Department of Surgery, University of Wisconsin School of Medicine, Madison, WI ¶Department of Surgery, Northwestern University Feinberg School of Medicine, Evanston, IL ‖Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH **Department of Surgery, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC ††Department of Surgery, University of Louisville School of Medicine, Louisville, KY ‡‡Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN; and §§Department of Surgery, Washington University School of Medicine, St. Louis, MO.

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http://pdfs.journals.lww.com/annalsofsurgery/2014/09000/Valu
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/SLA.0000000000000890DOI Listing
September 2014

Small sample sorting of primary adherent cells by automated micropallet imaging and release.

Cytometry A 2014 Jul 17;85(7):642-9. Epub 2014 Jun 17.

Department of Biomedical Engineering, University of North Carolina, Chapel Hill, North Carolina 27599 and North Carolina State University, Raleigh, North Carolina, 27695.

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http://dx.doi.org/10.1002/cyto.a.22480DOI Listing
July 2014

Measurement of protein kinase B activity in single primary human pancreatic cancer cells.

Anal Chem 2014 May 18;86(9):4573-80. Epub 2014 Apr 18.

Department of Chemistry, University of North Carolina , Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/ac500616qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018172PMC
May 2014

Micropallet arrays for the capture, isolation and culture of circulating tumor cells from whole blood of mice engrafted with primary human pancreatic adenocarcinoma.

Biosens Bioelectron 2014 Apr 18;54:476-83. Epub 2013 Nov 18.

Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, United States; Joint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC 27599, United States; Joint Department of Biomedical Engineering, North Carolina State University, Raleigh, NC 27695, United States; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, United States; Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09565663130079
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http://dx.doi.org/10.1016/j.bios.2013.11.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947965PMC
April 2014

Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology.

Proc Natl Acad Sci U S A 2014 Feb 11;111(8):3110-5. Epub 2014 Feb 11.

Department of Genetics, Department of Medicine, Division of Hematology/Oncology, Department of Surgery, Department of Pathology and Laboratory Medicine, and Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.

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http://dx.doi.org/10.1073/pnas.1318376111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939870PMC
February 2014

Response to MLN8237 in pancreatic cancer is not dependent on RalA phosphorylation.

Mol Cancer Ther 2014 Jan 12;13(1):122-33. Epub 2013 Nov 12.

Corresponding Author: Jen Jen Yeh, The University of North Carolina at Chapel Hill, CB# 7213, 1150 Physicians Office Building, 101 Manning Drive, Chapel Hill, NC 27599-7213;

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http://dx.doi.org/10.1158/1535-7163.MCT-12-1232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910332PMC
January 2014

Intraoperative electron radiation therapy as an important treatment modality in retroperitoneal sarcoma.

J Surg Res 2013 Nov 29;185(1):245-9. Epub 2013 May 29.

Division of Surgical Oncology, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1016/j.jss.2013.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166614PMC
November 2013

Isolation and in vitro culture of rare cancer stem cells from patient-derived xenografts of pancreatic ductal adenocarcinoma.

Anal Chem 2013 Aug 15;85(15):7271-8. Epub 2013 Jul 15.

Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/ac401165sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754897PMC
August 2013

Fusobacterium is associated with colorectal adenomas.

PLoS One 2013 15;8(1):e53653. Epub 2013 Jan 15.

Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053653PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546075PMC
June 2013

GSK-3α promotes oncogenic KRAS function in pancreatic cancer via TAK1-TAB stabilization and regulation of noncanonical NF-κB.

Cancer Discov 2013 Jun 1;3(6):690-703. Epub 2013 Apr 1.

Department of Cell and Developmental Biology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679268PMC
June 2013

Relative value unit impact of complex skin closures to academic surgical melanoma practices.

Am J Surg 2012 Sep;204(3):327-31

Department of Surgery, Division of General Surgery and Trauma, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

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http://dx.doi.org/10.1016/j.amjsurg.2011.10.014DOI Listing
September 2012

Differential gene expression between African American and European American colorectal cancer patients.

PLoS One 2012 19;7(1):e30168. Epub 2012 Jan 19.

Department of Medicine/Gastroenterology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030168PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261881PMC
June 2012

The RalB small GTPase mediates formation of invadopodia through a GTPase-activating protein-independent function of the RalBP1/RLIP76 effector.

Mol Cell Biol 2012 Apr 13;32(8):1374-86. Epub 2012 Feb 13.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1128/MCB.06291-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318593PMC
April 2012

Phosphorylation by protein kinase Cα regulates RalB small GTPase protein activation, subcellular localization, and effector utilization.

J Biol Chem 2012 Apr 5;287(18):14827-36. Epub 2012 Mar 5.

Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.344986
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http://dx.doi.org/10.1074/jbc.M112.344986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340265PMC
April 2012

Activation and involvement of Ral GTPases in colorectal cancer.

Cancer Res 2011 Jan;71(1):206-15

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-10-1517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062918PMC
January 2011

Age and Breslow depth are associated with a positive sentinel lymph node in patients with cutaneous melanocytic tumors of uncertain malignant potential.

J Am Coll Surg 2010 Dec;211(6):744-8

Department of Surgery, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, NC 27599-7213, USA.

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http://dx.doi.org/10.1016/j.jamcollsurg.2010.07.020DOI Listing
December 2010

Postoperative hypocalcemia after parathyroidectomy for renal hyperparathyroidism in the era of cinacalcet.

Am Surg 2009 Sep;75(9):843-7

Department of Surgery, University of North Carolina School of Medicine at Chapel Hill, CB #7213, 105 Manning Drive, P.O. Box #1031, Chapel Hill, NC 27599-7213, USA.

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September 2009

Metastatic melanoma cells in the sentinel node cannot be ignored.

J Am Coll Surg 2009 May;208(5):924-9; discussion 929-30

Department of Surgery, Division of Surgical Oncology and Endocrine Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7213, USA.

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http://dx.doi.org/10.1016/j.jamcollsurg.2009.02.003DOI Listing
May 2009

Method of detection of initial recurrence of stage II/III cutaneous melanoma: analysis of the utility of follow-up staging.

Ann Surg Oncol 2009 Apr 20;16(4):941-7. Epub 2008 Dec 20.

Department of Surgery and The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7213, USA.

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http://dx.doi.org/10.1245/s10434-008-0238-yDOI Listing
April 2009

KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer.

Mol Cancer Ther 2009 Apr;8(4):834-43

Department of Surgery, University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, 450 West Drive, CB 7295, Chapel Hill, NC 27599-7295, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-0972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729756PMC
April 2009

Prognostic signature for pancreatic cancer: are we close?

Authors:
Jen Jen Yeh

Future Oncol 2009 Apr;5(3):313-21

University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, Division of Surgical Oncology, Campus Box 7213, 1150 POB, 170 Manning Drive, Chapel Hill, NC 27599-7213, USA.

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https://www.futuremedicine.com/doi/10.2217/fon.09.12
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http://dx.doi.org/10.2217/fon.09.12DOI Listing
April 2009

Utilization of total thyroidectomy for papillary thyroid cancer in the United States.

Surgery 2007 Dec 5;142(6):906-13; discussion 913.e1-2. Epub 2007 Nov 5.

Department of Surgery, Division of Surgical Oncology, Northwestern University, Chicago, Ill., USA.

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http://dx.doi.org/10.1016/j.surg.2007.09.002DOI Listing
December 2007

Targeting signal transduction in pancreatic cancer treatment.

Expert Opin Ther Targets 2007 May;11(5):673-94

University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, Division of Surgical Oncology, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1517/14728222.11.5.673 DOI Listing
May 2007

Limitations of ampullectomy in the treatment of nonfamilial ampullary neoplasms.

Ann Surg Oncol 2005 Dec 25;12(12):971-80. Epub 2005 Oct 25.

Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1245/ASO.2005.03.009DOI Listing
December 2005

Effectiveness of palliative procedures for intra-abdominal sarcomas.

Ann Surg Oncol 2005 Dec 25;12(12):1084-9. Epub 2005 Oct 25.

Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1245/ASO.2005.03.016DOI Listing
December 2005

Response of stage IV anal mucosal melanoma to chemotherapy.

Lancet Oncol 2005 Jun;6(6):438-9

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/S1470-2045(05)70212-6DOI Listing
June 2005

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model.

Proc Natl Acad Sci U S A 2003 Jun 10;100(13):7841-6. Epub 2003 Jun 10.

Department of Medical Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1232229100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164675PMC
June 2003