Jeffry R Alger

Jeffry R Alger

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Jeffry R Alger

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Dorsolateral prefrontal γ-aminobutyric acid in patients with treatment-resistant depression after transcranial magnetic stimulation measured with magnetic resonance spectroscopy

J Psychiatry Neurosci 2019 Nov;44(6):386-394

From the Neuromodulation Division, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles (Levitt, Diaz, Cook, Ginder, Krantz, Minzenberg, Vince-Cruz, Nguyen, Leuchter); the Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles (Levitt, Kalender, O’Neill, Cook, Krantz, Minzenberg, Leuchter); the Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles (Kalender); the Division of Child and Adolescent Psychiatry, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles (Levitt, O’Neill); the Department of Bioengineering, Henry Samueli School of Engineering at Applied Science at UCLA, Los Angeles (Cook); the Department of Neurology, UCLA David Geffen School of Medicine at UCLA, Los Angeles (Alger); the Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas (Alger); and the NeuroSpectroScopics, LCC, Sherman Oaks, California (Alger).

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http://dx.doi.org/10.1503/jpn.180230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821508PMC
November 2019

N-Acetyl and Glutamatergic Neurometabolites in Perisylvian Brain Regions of Methamphetamine Users.

Int J Neuropsychopharmacol 2019 01;22(1):1-9

Laboratory of Molecular Neuroimaging, Semel Institute for Neuroscience and Human Behavior and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California.

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http://dx.doi.org/10.1093/ijnp/pyy042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313110PMC
January 2019

Whole Brain Magnetic Resonance Spectroscopic Determinants of Functional Outcomes in Pediatric Moderate/Severe Traumatic Brain Injury.

J Neurotrauma 2018 07 18;35(14):1637-1645. Epub 2018 May 18.

11 Departments of Psychology and Psychiatry and Brain Research Institute , David Geffen School of Medicine, Los Angeles, California.

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http://dx.doi.org/10.1089/neu.2017.5366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016095PMC
July 2018

tcaSIM: A Simulation Program for Optimal Design of C Tracer Experiments for Analysis of Metabolic Flux by NMR and Mass Spectroscopy.

Curr Metabolomics 2018 ;6(3):176-187

Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.2174/2213235X07666181219115856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863451PMC
January 2018

Multisite, multimodal neuroimaging of chronic urological pelvic pain: Methodology of the MAPP Research Network.

Neuroimage Clin 2016 6;12:65-77. Epub 2016 Jan 6.

UCLA Brain Research Institute, David Geffen School of Medicine at UCLA, USA; UCLA Ahmanson-Lovelace Brain Mapping Center, David Geffen School of Medicine at UCLA, USA; Department of Internal Medicine, David Geffen School of Medicine at UCLA, USA; Oppenheimer Center for Neurobiology of Stress at UCLA, David Geffen School of Medicine at UCLA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, USA.

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http://dx.doi.org/10.1016/j.nicl.2015.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925887PMC
November 2017

Cingulate and thalamic metabolites in obsessive-compulsive disorder.

Psychiatry Res Neuroimaging 2016 Aug 24;254:34-40. Epub 2016 May 24.

Division of Adult Psychiatry, UCLA Semel Institute for Neuroscience, Los Angeles, CA, United States.

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http://dx.doi.org/10.1016/j.pscychresns.2016.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780184PMC
August 2016

Plasma and Cerebrospinal Fluid Biomarkers Predict Cerebral Injury in HIV-Infected Individuals on Stable Combination Antiretroviral Therapy.

J Acquir Immune Defic Syndr 2015 May;69(1):29-35

*Emory University, Atlanta, GA; †Indiana University, Indianapolis, IN; ‡University of California, San Diego, San Diego, CA; §University of California, Los Angeles, CA; ‖University of Rochester School of Medicine, Rochester, NY; ¶University of Colorado Medical Center, Denver, CO; #University of Pittsburgh, Pittsburgh, PA; **University of Hawaii, Honolulu, HI; ††University of Florida, Gainesville, FL; and ‡‡Tufts University School of Medicine, Boston, MA.

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http://dx.doi.org/10.1097/QAI.0000000000000532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424074PMC
May 2015

Relationship between hippocampal atrophy and neuropathology markers: a 7T MRI validation study of the EADC-ADNI Harmonized Hippocampal Segmentation Protocol.

Alzheimers Dement 2015 Feb 22;11(2):139-50. Epub 2015 Jan 22.

LENITEM (Laboratory of Epidemiology, Neuroimaging and Telemedicine), IRCCS S.Giovanni di Dio- Fatebenefratelli, Brescia, Italy; University Hospitals and University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.jalz.2015.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348340PMC
February 2015

Multi-delay arterial spin labeling perfusion MRI in moyamoya disease--comparison with CT perfusion imaging.

Eur Radiol 2014 May 21;24(5):1135-44. Epub 2014 Feb 21.

State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing, 100101, China.

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http://dx.doi.org/10.1007/s00330-014-3098-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143230PMC
May 2014

Early metabolic crisis-related brain atrophy and cognition in traumatic brain injury.

Brain Imaging Behav 2013 Sep;7(3):307-15

Los Angeles Biomedical Research Institute, Psychology Division, Department of Psychiatry, Harbor-University of California, Los Angeles Medical Center, 1124 W. Carson St., B-4 South (Box 490), Torrance, CA, 90502, USA,

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http://link.springer.com/10.1007/s11682-013-9231-6
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http://dx.doi.org/10.1007/s11682-013-9231-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172457PMC
September 2013

Acute Stroke Imaging Research Roadmap II.

Stroke 2013 Sep 16;44(9):2628-39. Epub 2013 Jul 16.

Department of Radiology, University of Virginia, Charlottesville, VA, USA.

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http://www.thestair.org/sites/default/files/files/Imaging.pd
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http://stroke.ahajournals.org/cgi/doi/10.1161/STROKEAHA.113.
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http://dx.doi.org/10.1161/STROKEAHA.113.002015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040226PMC
September 2013

Ensemble segmentation for GBM brain tumors on MR images using confidence-based averaging.

Med Phys 2013 Sep;40(9):093502

TeraRecon Inc., 4000 East 3rd Avenue, Suite 200, Foster City, California 94404, USA.

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http://dx.doi.org/10.1118/1.4817475DOI Listing
September 2013

DTI tractography and white matter fiber tract characteristics in euthymic bipolar I patients and healthy control subjects.

Brain Imaging Behav 2013 Jun;7(2):129-39

Laboratory of Neuro Imaging LONI, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, 635 Charles E. Young Dr. S, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1007/s11682-012-9202-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572298PMC
June 2013

Utility of multiparametric 3-T MRI for glioma characterization.

Neuroradiology 2013 May 2;55(5):603-13. Epub 2013 Feb 2.

Department of Radiology & Imaging, Fortis Memorial Research Institute, Gurgaon, Haryana, India 122002.

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http://dx.doi.org/10.1007/s00234-013-1145-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209475PMC
May 2013

1H MRSI of middle frontal gyrus in pediatric ADHD.

J Psychiatr Res 2013 Apr 27;47(4):505-12. Epub 2012 Dec 27.

Ahmanson-Lovelace Brain Mapping Center in the Department of Neurology, 660 Charles Young Dr. So. Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.jpsychires.2012.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609653PMC
April 2013

Brain growth rate abnormalities visualized in adolescents with autism.

Hum Brain Mapp 2013 Feb 20;34(2):425-36. Epub 2011 Oct 20.

Laboratory of Neuro Imaging, University of California Los Angeles School of Medicine, Los Angeles, California, USA.

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http://dx.doi.org/10.1002/hbm.21441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144412PMC
February 2013

Regional prediction of tissue fate in acute ischemic stroke.

Ann Biomed Eng 2012 Oct 17;40(10):2177-87. Epub 2012 May 17.

Department of Neurology & Neurosurgery, Geffen School of Medicine, University of California, Los Angeles, USA.

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http://link.springer.com/content/pdf/10.1007/s10439-012-0591
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http://link.springer.com/10.1007/s10439-012-0591-7
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http://dx.doi.org/10.1007/s10439-012-0591-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647682PMC
October 2012

Clinical utility of magnetic resonance spectroscopy to enhance diagnosis of HIV-associated mild neurocognitive disorder.

Neuropsychiatry (London) 2012 Oct;2(5):379-383

Department of Mental Health, AIDS Healthcare Foundation (AHF), 6255 W Sunset Boulevard, 21st Floor, Los Angeles, CA 90028, USA.

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http://dx.doi.org/10.2217/npy.12.50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652484PMC
October 2012

The diffusion tensor imaging toolbox.

Authors:
Jeffry R Alger

J Neurosci 2012 May;32(22):7418-28

Department of Neurology, Department of Radiological Sciences, Interdepartmental Program in Biomedical Engineering, Ahmanson-Lovelace Brain Mapping Center, Brain Research Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-7085, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.4687-11.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444512PMC
May 2012

MRSI correlates of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder.

Prog Neuropsychopharmacol Biol Psychiatry 2012 Jan 1;36(1):161-8. Epub 2011 Oct 1.

Division of Child & Adolescent Psychiatry, Semel Institute for Neurosciences, Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, CA 90024-1759, United States.

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http://dx.doi.org/10.1016/j.pnpbp.2011.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344316PMC
January 2012

Diminished gray matter within the hypothalamus in autism disorder: a potential link to hormonal effects?

Biol Psychiatry 2011 Aug 4;70(3):278-82. Epub 2011 May 4.

Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine, University of California at Los Angeles, 760 Westwood Plaza 47-417, Los Angeles, CA 90024-1759, USA.

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http://dx.doi.org/10.1016/j.biopsych.2011.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134572PMC
August 2011

Mean diffusivity and fractional anisotropy as indicators of disease and genetic liability to schizophrenia.

J Psychiatr Res 2011 Jul 8;45(7):980-8. Epub 2011 Feb 8.

Laboratory of Neuro Imaging, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1016/j.jpsychires.2011.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109158PMC
July 2011

White matter connectivity of human hypothalamus.

Brain Res 2011 Jan 29;1371:43-64. Epub 2010 Nov 29.

Univ Clermont 1, UFR Médecine, EA3295, Equipe de Recherche en signal et Imagerie Médicale, Clermont-Ferrand, F-63001, France.

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http://dx.doi.org/10.1016/j.brainres.2010.11.072DOI Listing
January 2011

Early nonischemic oxidative metabolic dysfunction leads to chronic brain atrophy in traumatic brain injury.

J Cereb Blood Flow Metab 2010 Apr 23;30(4):883-94. Epub 2009 Dec 23.

Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1038/jcbfm.2009.263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949156PMC
April 2010

Quantitative proton magnetic resonance spectroscopy and spectroscopic imaging of the brain: a didactic review.

Authors:
Jeffry R Alger

Top Magn Reson Imaging 2010 Apr;21(2):115-28

Department of Neurology, Ahmanson-Lovelace Brain Mapping Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-7085, USA.

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http://dx.doi.org/10.1097/RMR.0b013e31821e568fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103086PMC
April 2010

Metabolic levels in the corpus callosum and their structural and behavioral correlates after moderate to severe pediatric TBI.

J Neurotrauma 2010 Mar;27(3):473-81

Semel Institute for Neuroscience and Human Behavior Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California-Los Angeles, 760 Westwood Plaza, Room C8-746, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1089/neu.2009.1058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867590PMC
March 2010

Impact of reperfusion after 3 hours of symptom onset on tissue fate in acute cerebral ischemia.

J Neuroimaging 2009 Oct 21;19(4):317-22. Epub 2008 Oct 21.

Department of Neurology, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1111/j.1552-6569.2008.00303.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755618PMC
October 2009

MR mismatch profiles in patients with intracranial atherosclerotic stroke: a comprehensive approach comparing stroke subtypes.

J Cereb Blood Flow Metab 2009 Jun 15;29(6):1138-45. Epub 2009 Apr 15.

Department of Neurology, Stroke and Cerebrovascular Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

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http://dx.doi.org/10.1038/jcbfm.2009.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731671PMC
June 2009

Patterns and predictors of blood-brain barrier permeability derangements in acute ischemic stroke.

Stroke 2009 Feb 26;40(2):454-61. Epub 2008 Nov 26.

Department of Neurology, Samsung Medical Center, Sungkyunkwan University, South Korea.

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http://dx.doi.org/10.1161/STROKEAHA.108.522847DOI Listing
February 2009

Contrast agent dose effects in cerebral dynamic susceptibility contrast magnetic resonance perfusion imaging.

J Magn Reson Imaging 2009 Jan;29(1):52-64

Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1002/jmri.21613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731672PMC
January 2009

Reduced white matter integrity in attention-deficit hyperactivity disorder.

Neuroreport 2008 Nov;19(17):1705-8

Laboratory of Neuro Imaging, UCLA Neuropsychiatric Institute and Hospital in Los Angeles, Geffen School of Medicine at UCLA, Los Angeles, California, USA.

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http://dx.doi.org/10.1097/WNR.0b013e3283174415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819371PMC
November 2008

Diffusion tensor imaging demonstrates brainstem and cerebellar abnormalities in congenital central hypoventilation syndrome.

Pediatr Res 2008 Sep;64(3):275-80

Department of Neurobiology, University of California at Los Angeles, Los Angeles, California 90095-1763, USA.

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http://dx.doi.org/10.1203/PDR.0b013e31817da10aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682538PMC
September 2008

Thrombolytic toxicity: blood brain barrier disruption in human ischemic stroke.

Cerebrovasc Dis 2008 27;25(4):338-43. Epub 2008 Feb 27.

Department of Neurology, Georgetown University, Washington, DC 20010, USA.

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http://dx.doi.org/10.1159/000118379DOI Listing
July 2008

Predictors of cerebral microbleeds in acute ischemic stroke and TIA patients.

Cerebrovasc Dis 2006 4;22(5-6):378-83. Epub 2006 Aug 4.

UCLA Stroke Center, UCLA Medical Center, Los Angeles, Ca 90095, USA.

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https://www.karger.com/Article/FullText/94855
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http://dx.doi.org/10.1159/000094855DOI Listing
January 2007

Elevated mean diffusivity in widespread brain regions in congenital central hypoventilation syndrome.

J Magn Reson Imaging 2006 Dec;24(6):1252-8

Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095-1763, USA.

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http://doi.wiley.com/10.1002/jmri.20759
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http://dx.doi.org/10.1002/jmri.20759DOI Listing
December 2006

Inspiratory loading elicits aberrant fMRI signal changes in obstructive sleep apnea.

Respir Physiol Neurobiol 2006 Mar 1;151(1):44-60. Epub 2005 Jul 1.

Department of Neurobiology, University of California, Los Angeles, 90095-1763, USA.

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http://dx.doi.org/10.1016/j.resp.2005.05.024DOI Listing
March 2006

MRI measurement of the uptake and retention of motexafin gadolinium in glioblastoma multiforme and uninvolved normal human brain.

J Neurooncol 2006 Mar 18;77(1):95-103. Epub 2006 Mar 18.

Inter-Departmental Graduate Program in Biomedical Physics, University of California at Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1007/s11060-005-9101-1DOI Listing
March 2006

Neuroanatomic deficits in congenital central hypoventilation syndrome.

J Comp Neurol 2005 Jul;487(4):361-71

Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, California 90095-1763, USA.

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http://dx.doi.org/10.1002/cne.20565DOI Listing
July 2005

Evolving paradigms in neuroimaging of the ischemic penumbra.

Stroke 2004 Nov 7;35(11 Suppl 1):2662-5. Epub 2004 Oct 7.

UCLA Stroke Center, 710 Westwood Plaza, UCLA Medical Center, Los Angeles, CA 9009, USA5.

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http://dx.doi.org/10.1161/01.STR.0000143222.13069.70DOI Listing
November 2004

1H MRSI evidence of metabolic abnormalities in childhood-onset schizophrenia.

Neuroimage 2004 Apr;21(4):1781-9

Division of Child and Adolescent Psychiatry, University of California at Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2003.11.005DOI Listing
April 2004

Predictors of apparent diffusion coefficient normalization in stroke patients.

Stroke 2004 Feb 22;35(2):514-9. Epub 2004 Jan 22.

Department of Neuroradiology, University Hospital Eppendorf, University of Hamburg, Hamburg, Germany.

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http://dx.doi.org/10.1161/01.STR.0000114873.28023.C2DOI Listing
February 2004

Global BOLD MRI changes to ventilatory challenges in congenital central hypoventilation syndrome.

Respir Physiol Neurobiol 2003 Dec;139(1):41-50

Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095-1763, USA.

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http://dx.doi.org/10.1016/j.resp.2003.09.006DOI Listing
December 2003

Beyond mismatch: evolving paradigms in imaging the ischemic penumbra with multimodal magnetic resonance imaging.

Stroke 2003 Nov 23;34(11):2729-35. Epub 2003 Oct 23.

University of California at Los Angeles Stroke Center, Los Angeles, CA 90095, USA.

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https://www.ahajournals.org/doi/10.1161/01.STR.0000097608.38
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http://dx.doi.org/10.1161/01.STR.0000097608.38779.CCDOI Listing
November 2003

Proton echo-planar spectroscopic imaging with highly effective outer volume suppression using combined presaturation and spatially selective echo dephasing.

Magn Reson Med 2003 May;49(5):817-21

Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA.

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http://dx.doi.org/10.1002/mrm.10449DOI Listing
May 2003

fMRI responses to cold pressor challenges in control and obstructive sleep apnea subjects.

J Appl Physiol (1985) 2003 Apr 3;94(4):1583-95. Epub 2003 Jan 3.

Departments of Neurobiology, Radiology, and Neurology, School of Nursing, and Brain Research Institute, University of California at Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1152/japplphysiol.00881.2002DOI Listing
April 2003

Neural responses during Valsalva maneuvers in obstructive sleep apnea syndrome.

J Appl Physiol (1985) 2003 Mar 1;94(3):1063-74. Epub 2002 Nov 1.

Department of Neurobiology, School of Nursing, University of California, Los Angeles, Los Angeles, California 90095-1763, USA.

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http://dx.doi.org/10.1152/japplphysiol.00702.2002DOI Listing
March 2003

Late secondary ischemic injury in patients receiving intraarterial thrombolysis.

Ann Neurol 2002 Dec;52(6):698-703

Stroke Center, UCLA Medical Center, 710 Westwood Plaza, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1002/ana.10380DOI Listing
December 2002

Brain responses associated with the Valsalva maneuver revealed by functional magnetic resonance imaging.

J Neurophysiol 2002 Dec;88(6):3477-86

Department of Neurobiology, University of California at Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1152/jn.00107.2002DOI Listing
December 2002

Brain morphology associated with obstructive sleep apnea.

Am J Respir Crit Care Med 2002 Nov;166(10):1382-7

Department of Neurobiology and the Brain Research Institute, University of California at Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1164/rccm.200201-050OCDOI Listing
November 2002

Novel methodology for the archiving and interactive reading of clinical magnetic resonance spectroscopic imaging.

Magn Reson Med 2002 Sep;48(3):411-8

Department of Radiology, University of California-Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1002/mrm.10239DOI Listing
September 2002