Publications by authors named "Jeffrey Settleman"

100Publications

Challenges in validating candidate therapeutic targets in cancer.

Elife 2018 02 8;7. Epub 2018 Feb 8.

Salk Institute for Biological Studies, La Jolla, United States.

View Article and Find Full Text PDF
February 2018

Differential Effects of Tyrosine Kinase Inhibitors on Normal and Oncogenic EGFR Signaling and Downstream Effectors.

Mol Cancer Res 2015 Apr 8;13(4):765-74. Epub 2015 Jan 8.

Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut.

View Article and Find Full Text PDF
April 2015

Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes.

Cancer Res 2014 Jun 22;74(11):3114-26. Epub 2014 Apr 22.

Authors' Affiliations: Departments of Discovery Oncology, Molecular Biology, Bioinformatics, Pathology, and Molecular Oncology, Genentech Inc., South San Francisco, California

View Article and Find Full Text PDF
June 2014

EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity.

Cancer Res 2013 Oct 21;73(20):6254-63. Epub 2013 Aug 21.

Authors' Affiliations: Laboratory of Cellular & Molecular Radiation Oncology, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Charlestown; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston; and Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts; Research Oncology, Genentech, Inc., South San Francisco, California; Department of Pharmaceutical Biology, Ludwig Maximilian University of Munich, Munich; and Center for Oncology, University Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany.

View Article and Find Full Text PDF
October 2013

Temporal resolution of autophosphorylation for normal and oncogenic forms of EGFR and differential effects of gefitinib.

Biochemistry 2012 Jun 13;51(25):5212-22. Epub 2012 Jun 13.

Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA.

View Article and Find Full Text PDF
June 2012

Oncogene addiction.

Curr Biol 2012 Jan;22(2):R43-4

Department of Discovery Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

View Article and Find Full Text PDF
January 2012

EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling.

Growth Factors 2012 Apr 20;30(2):107-16. Epub 2012 Jan 20.

Purdue University College of Pharmacy, Purdue University Center for Cancer Research, West Lafayette, IN 47907-2064, USA.

View Article and Find Full Text PDF
April 2012

The Q43L mutant of neuregulin 2β is a pan-ErbB receptor antagonist.

Biochem J 2012 Apr;443(1):133-44

Purdue University College of Pharmacy and Purdue University Center for Cancer Research, West Lafayette, IN 47907-2064, USA.

View Article and Find Full Text PDF
April 2012

EGF receptor inhibition radiosensitizes NSCLC cells by inducing senescence in cells sustaining DNA double-strand breaks.

Cancer Res 2011 Oct 18;71(19):6261-9. Epub 2011 Aug 18.

Laboratory of Cellular & Molecular Radiation Oncology, Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts, USA.

View Article and Find Full Text PDF
October 2011

A kinase shRNA screen links LATS2 and the pRB tumor suppressor.

Genes Dev 2011 Apr;25(8):814-30

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

View Article and Find Full Text PDF
April 2011

Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.

Blood 2009 Oct 27;114(17):3557-66. Epub 2009 Aug 27.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Research Foundation, Cincinnati, OH 45229, USA.

View Article and Find Full Text PDF
October 2009

Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression.

Breast Cancer Res 2009 24;11(4):R61. Epub 2009 Aug 24.

Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

View Article and Find Full Text PDF
February 2010

Regulation of the substrate preference of p190RhoGAP by protein kinase C-mediated phosphorylation of a phospholipid binding site.

Biochemistry 2009 Sep;48(36):8615-23

Department of Physiology, Semmelweis University, 1094 Budapest, Tuzolto u. 37-47, Hungary.

View Article and Find Full Text PDF
September 2009

Isoform-specific ras functions in development and cancer.

Future Oncol 2009 Feb;5(1):105-16

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.

View Article and Find Full Text PDF
February 2009

Coordination of Rho and Rac GTPase function via p190B RhoGAP.

Curr Biol 2008 Oct;18(20):1606-11

GI Cell Biology Laboratory, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA.

View Article and Find Full Text PDF
October 2008

Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion.

Cancer Res 2008 Oct;68(19):7779-87

Institute of Molecular Medicine, Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan.

View Article and Find Full Text PDF
October 2008

ErbBs in lung cancer.

Exp Cell Res 2009 Feb 6;315(4):557-71. Epub 2008 Aug 6.

Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.

View Article and Find Full Text PDF
February 2009

Modeling oncogene addiction using RNA interference.

Proc Natl Acad Sci U S A 2008 Aug 18;105(34):12480-4. Epub 2008 Aug 18.

Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.

View Article and Find Full Text PDF
August 2008

[A Kras-specific function in cancer initiation].

Ai Zheng 2008 Jul;27(7):673-4

Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.

View Article and Find Full Text PDF
July 2008

Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma.

Cancer Res 2008 Jun;68(12):4853-61

Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts, USA.

View Article and Find Full Text PDF
June 2008

p190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4.

J Cell Biol 2008 Jun 9;181(6):1013-26. Epub 2008 Jun 9.

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, England, UK.

View Article and Find Full Text PDF
June 2008

p190A RhoGAP is a glycogen synthase kinase-3-beta substrate required for polarized cell migration.

J Biol Chem 2008 Jul 23;283(30):20978-88. Epub 2008 May 23.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA.

View Article and Find Full Text PDF
July 2008

Explaining the preponderance of Kras mutations in human cancer: An isoform-specific function in stem cell expansion.

Cell Cycle 2008 May 11;7(10):1332-5. Epub 2008 Mar 11.

Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachussets, USA.

View Article and Find Full Text PDF
May 2008

High-throughput lung cancer cell line screening for genotype-correlated sensitivity to an EGFR kinase inhibitor.

Methods Enzymol 2008 ;438:331-41

Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, USA.

View Article and Find Full Text PDF
June 2008

Transitions between epithelial and mesenchymal states in development and disease.

Semin Cell Dev Biol 2008 Jun 9;19(3):294-308. Epub 2008 Feb 9.

Department of Cell and Developmental Biology, UCL, London, UK.

View Article and Find Full Text PDF
June 2008

Acquired resistance to tyrosine kinase inhibitors during cancer therapy.

Curr Opin Genet Dev 2008 Feb 5;18(1):73-9. Epub 2008 Mar 5.

Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.

View Article and Find Full Text PDF
February 2008

Cell shape and tissue morphogenesis.

Semin Cell Dev Biol 2008 Jun 15;19(3):213-4. Epub 2008 Feb 15.

View Article and Find Full Text PDF
June 2008

Targeted combinatorial therapy of non-small cell lung carcinoma using a GST-fusion protein of full-length or truncated MDA-7/IL-24 with Tarceva.

J Cell Physiol 2008 Jun;215(3):827-36

Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA.

View Article and Find Full Text PDF
June 2008

Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion.

Mol Cell Biol 2008 Apr 11;28(8):2659-74. Epub 2008 Feb 11.

Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.

View Article and Find Full Text PDF
April 2008

GEFs in growth factor signaling.

Growth Factors 2007 Oct;25(5):355-61

Harvard Medical School and Massachusetts General Hospital, Center for Cancer Research, Charlestown, MA 02129, USA.

View Article and Find Full Text PDF
October 2007

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.

Authors:
Daniel J Klionsky Hagai Abeliovich Patrizia Agostinis Devendra K Agrawal Gjumrakch Aliev David S Askew Misuzu Baba Eric H Baehrecke Ben A Bahr Andrea Ballabio Bruce A Bamber Diane C Bassham Ettore Bergamini Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Dale E Bredesen Jeffrey L Brodsky John H Brumell Ulf T Brunk Wilfried Bursch Nadine Camougrand Eduardo Cebollero Francesco Cecconi Yingyu Chen Lih-Shen Chin Augustine Choi Charleen T Chu Jongkyeong Chung Peter G H Clarke Robert S B Clark Steven G Clarke Corinne Clavé John L Cleveland Patrice Codogno María I Colombo Ana Coto-Montes James M Cregg Ana Maria Cuervo Jayanta Debnath Francesca Demarchi Patrick B Dennis Phillip A Dennis Vojo Deretic Rodney J Devenish Federica Di Sano J Fred Dice Marian Difiglia Savithramma Dinesh-Kumar Clark W Distelhorst Mojgan Djavaheri-Mergny Frank C Dorsey Wulf Dröge Michel Dron William A Dunn Michael Duszenko N Tony Eissa Zvulun Elazar Audrey Esclatine Eeva-Liisa Eskelinen László Fésüs Kim D Finley José M Fuentes Juan Fueyo Kozo Fujisaki Brigitte Galliot Fen-Biao Gao David A Gewirtz Spencer B Gibson Antje Gohla Alfred L Goldberg Ramon Gonzalez Cristina González-Estévez Sharon Gorski Roberta A Gottlieb Dieter Häussinger You-Wen He Kim Heidenreich Joseph A Hill Maria Høyer-Hansen Xun Hu Wei-Pang Huang Akiko Iwasaki Marja Jäättelä William T Jackson Xuejun Jiang Shengkan Jin Terje Johansen Jae U Jung Motoni Kadowaki Chanhee Kang Ameeta Kelekar David H Kessel Jan A K W Kiel Hong Pyo Kim Adi Kimchi Timothy J Kinsella Kirill Kiselyov Katsuhiko Kitamoto Erwin Knecht Masaaki Komatsu Eiki Kominami Seiji Kondo Attila L Kovács Guido Kroemer Chia-Yi Kuan Rakesh Kumar Mondira Kundu Jacques Landry Marianne Laporte Weidong Le Huan-Yao Lei Michael J Lenardo Beth Levine Andrew Lieberman Kah-Leong Lim Fu-Cheng Lin Willisa Liou Leroy F Liu Gabriel Lopez-Berestein Carlos López-Otín Bo Lu Kay F Macleod Walter Malorni Wim Martinet Ken Matsuoka Josef Mautner Alfred J Meijer Alicia Meléndez Paul Michels Giovanni Miotto Wilhelm P Mistiaen Noboru Mizushima Baharia Mograbi Iryna Monastyrska Michael N Moore Paula I Moreira Yuji Moriyasu Tomasz Motyl Christian Münz Leon O Murphy Naweed I Naqvi Thomas P Neufeld Ichizo Nishino Ralph A Nixon Takeshi Noda Bernd Nürnberg Michinaga Ogawa Nancy L Oleinick Laura J Olsen Bulent Ozpolat Shoshana Paglin Glen E Palmer Issidora Papassideri Miles Parkes David H Perlmutter George Perry Mauro Piacentini Ronit Pinkas-Kramarski Mark Prescott Tassula Proikas-Cezanne Nina Raben Abdelhaq Rami Fulvio Reggiori Bärbel Rohrer David C Rubinsztein Kevin M Ryan Junichi Sadoshima Hiroshi Sakagami Yasuyoshi Sakai Marco Sandri Chihiro Sasakawa Miklós Sass Claudio Schneider Per O Seglen Oleksandr Seleverstov Jeffrey Settleman John J Shacka Irving M Shapiro Andrei Sibirny Elaine C M Silva-Zacarin Hans-Uwe Simon Cristiano Simone Anne Simonsen Mark A Smith Katharina Spanel-Borowski Vickram Srinivas Meredith Steeves Harald Stenmark Per E Stromhaug Carlos S Subauste Seiichiro Sugimoto David Sulzer Toshihiko Suzuki Michele S Swanson Ira Tabas Fumihiko Takeshita Nicholas J Talbot Zsolt Tallóczy Keiji Tanaka Kozo Tanaka Isei Tanida Graham S Taylor J Paul Taylor Alexei Terman Gianluca Tettamanti Craig B Thompson Michael Thumm Aviva M Tolkovsky Sharon A Tooze Ray Truant Lesya V Tumanovska Yasuo Uchiyama Takashi Ueno Néstor L Uzcátegui Ida van der Klei Eva C Vaquero Tibor Vellai Michael W Vogel Hong-Gang Wang Paul Webster John W Wiley Zhijun Xi Gutian Xiao Joachim Yahalom Jin-Ming Yang George Yap Xiao-Ming Yin Tamotsu Yoshimori Li Yu Zhenyu Yue Michisuke Yuzaki Olga Zabirnyk Xiaoxiang Zheng Xiongwei Zhu Russell L Deter

Autophagy 2008 Feb 21;4(2):151-75. Epub 2007 Nov 21.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.

View Article and Find Full Text PDF
February 2008

Oncogene addiction: setting the stage for molecularly targeted cancer therapy.

Genes Dev 2007 Dec;21(24):3214-31

Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

View Article and Find Full Text PDF
December 2007

Drugging the bad "AKT-TOR" to overcome TKI-resistant lung cancer.

Cancer Cell 2007 Jul;12(1):6-8

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA.

View Article and Find Full Text PDF
July 2007

Mutational activation of ErbB family receptor tyrosine kinases: insights into mechanisms of signal transduction and tumorigenesis.

Bioessays 2007 Jun;29(6):558-65

Purdue University School of Pharmacy and Purdue Cancer Research Center, 201 S. University Street, West Lafayette, IN 47907, USA.

View Article and Find Full Text PDF
June 2007

A rho-binding protein kinase C-like activity is required for the function of protein kinase N in Drosophila development.

Genetics 2007 Aug 16;176(4):2201-12. Epub 2007 May 16.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA.

View Article and Find Full Text PDF
August 2007

Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib.

Cancer Res 2007 Mar;67(5):2325-30

Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA.

View Article and Find Full Text PDF
March 2007

Epidermal growth factor receptor mutations in lung cancer.

Nat Rev Cancer 2007 Mar;7(3):169-81

Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA.

View Article and Find Full Text PDF
March 2007

PAK-in' up cGMP for the move.

Cell 2007 Jan;128(2):237-8

MGH Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.

View Article and Find Full Text PDF
January 2007

Oncogenic shock: turning an activated kinase against the tumor cell.

Cell Cycle 2006 Dec 13;5(24):2878-80. Epub 2006 Dec 13.

Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

View Article and Find Full Text PDF
December 2006

Combinatorial treatment of non-small-cell lung cancers with gefitinib and Ad.mda-7 enhances apoptosis-induction and reverses resistance to a single therapy.

J Cell Physiol 2007 Feb;210(2):549-59

Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York 10032, USA.

View Article and Find Full Text PDF
February 2007

A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes.

Cancer Cell 2006 Nov;10(5):425-35

Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA.

View Article and Find Full Text PDF
November 2006

Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression.

Mol Cell 2006 Oct;24(2):301-8

Program in Immunology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, Massachusetts 02111, USA.

View Article and Find Full Text PDF
October 2006

Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane.

Mol Biol Cell 2006 Nov 13;17(11):4827-36. Epub 2006 Sep 13.

Department of Molecular Biophysics and Biochemistry, Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06520, USA.

View Article and Find Full Text PDF
November 2006

The complexity of targeting EGFR signalling in cancer: from expression to turnover.

Biochim Biophys Acta 2006 Aug 23;1766(1):120-39. Epub 2006 Jun 23.

Clinical Experimental Oncology Laboratory, National Cancer Institute, Via Amendola, 209, 70126, Bari, Italy.

View Article and Find Full Text PDF
August 2006

Drosophila Rho-kinase (DRok) is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis.

Dev Biol 2006 Sep 19;297(2):417-32. Epub 2006 May 19.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.

View Article and Find Full Text PDF
September 2006

Rho-kinase regulates tissue morphogenesis via non-muscle myosin and LIM-kinase during Drosophila development.

BMC Dev Biol 2006 Aug 1;6:38. Epub 2006 Aug 1.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA.

View Article and Find Full Text PDF
August 2006

"Oncogenic shock": explaining oncogene addiction through differential signal attenuation.

Clin Cancer Res 2006 Jul;12(14 Pt 2):4392s-4395s

Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

View Article and Find Full Text PDF
July 2006

Regulation of the nucleotide state of oncogenic ras proteins by nucleoside diphosphate kinase.

Methods Enzymol 2006 ;407:33-45

General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts, USA.

View Article and Find Full Text PDF
June 2008

Regulation of RhoGAP specificity by phospholipids and prenylation.

Methods Enzymol 2006 ;406:104-17

Semmelweis University, Department of Physiology, Budapest, Hungary.

View Article and Find Full Text PDF
March 2006

Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752.

Proc Natl Acad Sci U S A 2006 Feb 6;103(7):2316-21. Epub 2006 Feb 6.

Cancer Center and Department of Pathology, Molecular Pathology Research Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

View Article and Find Full Text PDF
February 2006

GAPs in growth factor signalling.

Growth Factors 2005 Jun;23(2):143-9

Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.

View Article and Find Full Text PDF
June 2005