Jeffrey Settleman

Jeffrey Settleman

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Jeffrey Settleman

Publications by authors named "Jeffrey Settleman"

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Challenges in validating candidate therapeutic targets in cancer.

Elife 2018 02 8;7. Epub 2018 Feb 8.

Salk Institute for Biological Studies, La Jolla, United States.

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https://elifesciences.org/articles/32402
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http://dx.doi.org/10.7554/eLife.32402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805407PMC
February 2018

Differential Effects of Tyrosine Kinase Inhibitors on Normal and Oncogenic EGFR Signaling and Downstream Effectors.

Mol Cancer Res 2015 Apr 8;13(4):765-74. Epub 2015 Jan 8.

Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398619PMC
April 2015

Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes.

Cancer Res 2014 Jun 22;74(11):3114-26. Epub 2014 Apr 22.

Authors' Affiliations: Departments of Discovery Oncology, Molecular Biology, Bioinformatics, Pathology, and Molecular Oncology, Genentech Inc., South San Francisco, California

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-2683DOI Listing
June 2014

EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity.

Cancer Res 2013 Oct 21;73(20):6254-63. Epub 2013 Aug 21.

Authors' Affiliations: Laboratory of Cellular & Molecular Radiation Oncology, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Charlestown; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston; and Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts; Research Oncology, Genentech, Inc., South San Francisco, California; Department of Pharmaceutical Biology, Ludwig Maximilian University of Munich, Munich; and Center for Oncology, University Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823187PMC
October 2013

Interaction of the EGFR inhibitors gefitinib, vandetanib, pelitinib and neratinib with the ABCG2 multidrug transporter: implications for the emergence and reversal of cancer drug resistance.

Biochem Pharmacol 2012 Aug 21;84(3):260-7. Epub 2012 Apr 21.

Membrane Research Group of the Hungarian Academy of Sciences, Department of Biophysics, Semmelweis University and National Blood Center, Budapest, Hungary.

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http://dx.doi.org/10.1016/j.bcp.2012.04.010DOI Listing
August 2012

Temporal resolution of autophosphorylation for normal and oncogenic forms of EGFR and differential effects of gefitinib.

Biochemistry 2012 Jun 13;51(25):5212-22. Epub 2012 Jun 13.

Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1021/bi300476vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390174PMC
June 2012

The Q43L mutant of neuregulin 2β is a pan-ErbB receptor antagonist.

Biochem J 2012 Apr;443(1):133-44

Purdue University College of Pharmacy and Purdue University Center for Cancer Research, West Lafayette, IN 47907-2064, USA.

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http://dx.doi.org/10.1042/BJ20110921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960720PMC
April 2012

EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling.

Growth Factors 2012 Apr 20;30(2):107-16. Epub 2012 Jan 20.

Purdue University College of Pharmacy, Purdue University Center for Cancer Research, West Lafayette, IN 47907-2064, USA.

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http://dx.doi.org/10.3109/08977194.2011.649918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962550PMC
April 2012

Oncogene addiction.

Curr Biol 2012 Jan;22(2):R43-4

Department of Discovery Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.cub.2011.11.004DOI Listing
January 2012

A kinase shRNA screen links LATS2 and the pRB tumor suppressor.

Genes Dev 2011 Apr;25(8):814-30

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1101/gad.2000211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078707PMC
April 2011

Neurite outgrowth from PC12 cells by basic fibroblast growth factor (bFGF) is mediated by RhoA inactivation through p190RhoGAP and ARAP3.

J Cell Physiol 2010 Sep;224(3):786-94

Department of Biochemistry, Hallym University College of Medicine, Chuncheon, Kangwon-Do, South Korea.

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http://doi.wiley.com/10.1002/jcp.22184
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http://dx.doi.org/10.1002/jcp.22184DOI Listing
September 2010

Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression.

Breast Cancer Res 2009 24;11(4):R61. Epub 2009 Aug 24.

Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1186/bcr2352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750123PMC
February 2010

Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.

Blood 2009 Oct 27;114(17):3557-66. Epub 2009 Aug 27.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Research Foundation, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1182/blood-2009-02-205815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766675PMC
October 2009

Regulation of the substrate preference of p190RhoGAP by protein kinase C-mediated phosphorylation of a phospholipid binding site.

Biochemistry 2009 Sep;48(36):8615-23

Department of Physiology, Semmelweis University, 1094 Budapest, Tuzolto u. 37-47, Hungary.

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http://dx.doi.org/10.1021/bi900667yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739883PMC
September 2009

ErbBs in lung cancer.

Exp Cell Res 2009 Feb 6;315(4):557-71. Epub 2008 Aug 6.

Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.yexcr.2008.07.026DOI Listing
February 2009

Isoform-specific ras functions in development and cancer.

Future Oncol 2009 Feb;5(1):105-16

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.2217/14796694.5.1.105DOI Listing
February 2009

Loss of the Ras regulator RASAL1: another route to Ras activation in colorectal cancer.

Gastroenterology 2009 Jan 28;136(1):46-8. Epub 2008 Nov 28.

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http://dx.doi.org/10.1053/j.gastro.2008.11.024DOI Listing
January 2009

Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion.

Cancer Res 2008 Oct;68(19):7779-87

Institute of Molecular Medicine, Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-0997DOI Listing
October 2008

Coordination of Rho and Rac GTPase function via p190B RhoGAP.

Curr Biol 2008 Oct;18(20):1606-11

GI Cell Biology Laboratory, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.cub.2008.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084715PMC
October 2008

Modeling oncogene addiction using RNA interference.

Proc Natl Acad Sci U S A 2008 Aug 18;105(34):12480-4. Epub 2008 Aug 18.

Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1073/pnas.0803217105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517605PMC
August 2008

p190A RhoGAP is a glycogen synthase kinase-3-beta substrate required for polarized cell migration.

J Biol Chem 2008 Jul 23;283(30):20978-88. Epub 2008 May 23.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1074/jbc.M802588200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475707PMC
July 2008

[A Kras-specific function in cancer initiation].

Ai Zheng 2008 Jul;27(7):673-4

Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.

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July 2008

Regulation of the nucleotide state of oncogenic ras proteins by nucleoside diphosphate kinase.

Methods Enzymol 2006 ;407:33-45

General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1016/S0076-6879(05)07004-7DOI Listing
June 2008

Targeted combinatorial therapy of non-small cell lung carcinoma using a GST-fusion protein of full-length or truncated MDA-7/IL-24 with Tarceva.

J Cell Physiol 2008 Jun;215(3):827-36

Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA.

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http://dx.doi.org/10.1002/jcp.21369DOI Listing
June 2008

Cell shape and tissue morphogenesis.

Semin Cell Dev Biol 2008 Jun 15;19(3):213-4. Epub 2008 Feb 15.

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http://dx.doi.org/10.1016/j.semcdb.2008.02.002DOI Listing
June 2008

High-throughput lung cancer cell line screening for genotype-correlated sensitivity to an EGFR kinase inhibitor.

Methods Enzymol 2008 ;438:331-41

Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1016/S0076-6879(07)38023-3DOI Listing
June 2008

p190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4.

J Cell Biol 2008 Jun 9;181(6):1013-26. Epub 2008 Jun 9.

Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, England, UK.

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http://dx.doi.org/10.1083/jcb.200711129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426943PMC
June 2008

Explaining the preponderance of Kras mutations in human cancer: An isoform-specific function in stem cell expansion.

Cell Cycle 2008 May 11;7(10):1332-5. Epub 2008 Mar 11.

Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachussets, USA.

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http://dx.doi.org/10.4161/cc.7.10.5927DOI Listing
May 2008

Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion.

Mol Cell Biol 2008 Apr 11;28(8):2659-74. Epub 2008 Feb 11.

Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1128/MCB.01661-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2293097PMC
April 2008

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.

Authors:
Daniel J Klionsky Hagai Abeliovich Patrizia Agostinis Devendra K Agrawal Gjumrakch Aliev David S Askew Misuzu Baba Eric H Baehrecke Ben A Bahr Andrea Ballabio Bruce A Bamber Diane C Bassham Ettore Bergamini Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Dale E Bredesen Jeffrey L Brodsky John H Brumell Ulf T Brunk Wilfried Bursch Nadine Camougrand Eduardo Cebollero Francesco Cecconi Yingyu Chen Lih-Shen Chin Augustine Choi Charleen T Chu Jongkyeong Chung Peter G H Clarke Robert S B Clark Steven G Clarke Corinne Clavé John L Cleveland Patrice Codogno María I Colombo Ana Coto-Montes James M Cregg Ana Maria Cuervo Jayanta Debnath Francesca Demarchi Patrick B Dennis Phillip A Dennis Vojo Deretic Rodney J Devenish Federica Di Sano J Fred Dice Marian Difiglia Savithramma Dinesh-Kumar Clark W Distelhorst Mojgan Djavaheri-Mergny Frank C Dorsey Wulf Dröge Michel Dron William A Dunn Michael Duszenko N Tony Eissa Zvulun Elazar Audrey Esclatine Eeva-Liisa Eskelinen László Fésüs Kim D Finley José M Fuentes Juan Fueyo Kozo Fujisaki Brigitte Galliot Fen-Biao Gao David A Gewirtz Spencer B Gibson Antje Gohla Alfred L Goldberg Ramon Gonzalez Cristina González-Estévez Sharon Gorski Roberta A Gottlieb Dieter Häussinger You-Wen He Kim Heidenreich Joseph A Hill Maria Høyer-Hansen Xun Hu Wei-Pang Huang Akiko Iwasaki Marja Jäättelä William T Jackson Xuejun Jiang Shengkan Jin Terje Johansen Jae U Jung Motoni Kadowaki Chanhee Kang Ameeta Kelekar David H Kessel Jan A K W Kiel Hong Pyo Kim Adi Kimchi Timothy J Kinsella Kirill Kiselyov Katsuhiko Kitamoto Erwin Knecht Masaaki Komatsu Eiki Kominami Seiji Kondo Attila L Kovács Guido Kroemer Chia-Yi Kuan Rakesh Kumar Mondira Kundu Jacques Landry Marianne Laporte Weidong Le Huan-Yao Lei Michael J Lenardo Beth Levine Andrew Lieberman Kah-Leong Lim Fu-Cheng Lin Willisa Liou Leroy F Liu Gabriel Lopez-Berestein Carlos López-Otín Bo Lu Kay F Macleod Walter Malorni Wim Martinet Ken Matsuoka Josef Mautner Alfred J Meijer Alicia Meléndez Paul Michels Giovanni Miotto Wilhelm P Mistiaen Noboru Mizushima Baharia Mograbi Iryna Monastyrska Michael N Moore Paula I Moreira Yuji Moriyasu Tomasz Motyl Christian Münz Leon O Murphy Naweed I Naqvi Thomas P Neufeld Ichizo Nishino Ralph A Nixon Takeshi Noda Bernd Nürnberg Michinaga Ogawa Nancy L Oleinick Laura J Olsen Bulent Ozpolat Shoshana Paglin Glen E Palmer Issidora Papassideri Miles Parkes David H Perlmutter George Perry Mauro Piacentini Ronit Pinkas-Kramarski Mark Prescott Tassula Proikas-Cezanne Nina Raben Abdelhaq Rami Fulvio Reggiori Bärbel Rohrer David C Rubinsztein Kevin M Ryan Junichi Sadoshima Hiroshi Sakagami Yasuyoshi Sakai Marco Sandri Chihiro Sasakawa Miklós Sass Claudio Schneider Per O Seglen Oleksandr Seleverstov Jeffrey Settleman John J Shacka Irving M Shapiro Andrei Sibirny Elaine C M Silva-Zacarin Hans-Uwe Simon Cristiano Simone Anne Simonsen Mark A Smith Katharina Spanel-Borowski Vickram Srinivas Meredith Steeves Harald Stenmark Per E Stromhaug Carlos S Subauste Seiichiro Sugimoto David Sulzer Toshihiko Suzuki Michele S Swanson Ira Tabas Fumihiko Takeshita Nicholas J Talbot Zsolt Tallóczy Keiji Tanaka Kozo Tanaka Isei Tanida Graham S Taylor J Paul Taylor Alexei Terman Gianluca Tettamanti Craig B Thompson Michael Thumm Aviva M Tolkovsky Sharon A Tooze Ray Truant Lesya V Tumanovska Yasuo Uchiyama Takashi Ueno Néstor L Uzcátegui Ida van der Klei Eva C Vaquero Tibor Vellai Michael W Vogel Hong-Gang Wang Paul Webster John W Wiley Zhijun Xi Gutian Xiao Joachim Yahalom Jin-Ming Yang George Yap Xiao-Ming Yin Tamotsu Yoshimori Li Yu Zhenyu Yue Michisuke Yuzaki Olga Zabirnyk Xiaoxiang Zheng Xiongwei Zhu Russell L Deter

Autophagy 2008 Feb 21;4(2):151-75. Epub 2007 Nov 21.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.

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http://www.dwalab.ca/common/pdf/cdd200944a.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654259PMC
http://dx.doi.org/10.4161/auto.5338DOI Listing
February 2008

Acquired resistance to tyrosine kinase inhibitors during cancer therapy.

Curr Opin Genet Dev 2008 Feb 5;18(1):73-9. Epub 2008 Mar 5.

Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0959437X080000
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http://dx.doi.org/10.1016/j.gde.2008.01.004DOI Listing
February 2008

Genetic interactions between Drosophila melanogaster Atg1 and paxillin reveal a role for paxillin in autophagosome formation.

Autophagy 2008 Jan 8;4(1):37-45. Epub 2007 Oct 8.

Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.

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http://dx.doi.org/10.4161/auto.5141DOI Listing
January 2008

Oncogene addiction: setting the stage for molecularly targeted cancer therapy.

Genes Dev 2007 Dec;21(24):3214-31

Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1101/gad.1609907DOI Listing
December 2007

GEFs in growth factor signaling.

Growth Factors 2007 Oct;25(5):355-61

Harvard Medical School and Massachusetts General Hospital, Center for Cancer Research, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1080/08977190701830375DOI Listing
October 2007

A rho-binding protein kinase C-like activity is required for the function of protein kinase N in Drosophila development.

Genetics 2007 Aug 16;176(4):2201-12. Epub 2007 May 16.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1534/genetics.107.072967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950625PMC
August 2007

Drugging the bad "AKT-TOR" to overcome TKI-resistant lung cancer.

Cancer Cell 2007 Jul;12(1):6-8

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.ccr.2007.06.010DOI Listing
July 2007

Mutational activation of ErbB family receptor tyrosine kinases: insights into mechanisms of signal transduction and tumorigenesis.

Bioessays 2007 Jun;29(6):558-65

Purdue University School of Pharmacy and Purdue Cancer Research Center, 201 S. University Street, West Lafayette, IN 47907, USA.

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http://dx.doi.org/10.1002/bies.20582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789424PMC
June 2007

Epidermal growth factor receptor mutations in lung cancer.

Nat Rev Cancer 2007 Mar;7(3):169-81

Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/nrc2088DOI Listing
March 2007

Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib.

Cancer Res 2007 Mar;67(5):2325-30

Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4293DOI Listing
March 2007

Combinatorial treatment of non-small-cell lung cancers with gefitinib and Ad.mda-7 enhances apoptosis-induction and reverses resistance to a single therapy.

J Cell Physiol 2007 Feb;210(2):549-59

Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York 10032, USA.

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http://dx.doi.org/10.1002/jcp.20906DOI Listing
February 2007

PAK-in' up cGMP for the move.

Cell 2007 Jan;128(2):237-8

MGH Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.cell.2007.01.002DOI Listing
January 2007

p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho.

Cell 2006 Dec;127(5):1027-39

Department of Cancer Biology, 438 Preston Building, Vanderbilt University, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1016/j.cell.2006.09.046DOI Listing
December 2006

Oncogenic shock: turning an activated kinase against the tumor cell.

Cell Cycle 2006 Dec 13;5(24):2878-80. Epub 2006 Dec 13.

Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.4161/cc.5.24.3598DOI Listing
December 2006

Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane.

Mol Biol Cell 2006 Nov 13;17(11):4827-36. Epub 2006 Sep 13.

Department of Molecular Biophysics and Biochemistry, Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1091/mbc.e06-02-0132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635390PMC
November 2006

Distinct but overlapping functions for the closely related p190 RhoGAPs in neural development.

Dev Neurosci 2006 ;28(6):538-50

Department of Biology, Calvin College, Grand Rapids, MI, USA.

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http://dx.doi.org/10.1159/000095116DOI Listing
November 2006

A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes.

Cancer Cell 2006 Nov;10(5):425-35

Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1016/j.ccr.2006.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673136PMC
November 2006

Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression.

Mol Cell 2006 Oct;24(2):301-8

Program in Immunology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, Massachusetts 02111, USA.

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http://dx.doi.org/10.1016/j.molcel.2006.09.005DOI Listing
October 2006

Drosophila Rho-kinase (DRok) is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis.

Dev Biol 2006 Sep 19;297(2):417-32. Epub 2006 May 19.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.ydbio.2006.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504748PMC
September 2006

Rho-kinase regulates tissue morphogenesis via non-muscle myosin and LIM-kinase during Drosophila development.

BMC Dev Biol 2006 Aug 1;6:38. Epub 2006 Aug 1.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1186/1471-213X-6-38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1552057PMC
August 2006

The complexity of targeting EGFR signalling in cancer: from expression to turnover.

Biochim Biophys Acta 2006 Aug 23;1766(1):120-39. Epub 2006 Jun 23.

Clinical Experimental Oncology Laboratory, National Cancer Institute, Via Amendola, 209, 70126, Bari, Italy.

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http://dx.doi.org/10.1016/j.bbcan.2006.06.001DOI Listing
August 2006

"Oncogenic shock": explaining oncogene addiction through differential signal attenuation.

Clin Cancer Res 2006 Jul;12(14 Pt 2):4392s-4395s

Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-0096DOI Listing
July 2006

Regulation of RhoGAP specificity by phospholipids and prenylation.

Methods Enzymol 2006 ;406:104-17

Semmelweis University, Department of Physiology, Budapest, Hungary.

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http://dx.doi.org/10.1016/S0076-6879(06)06009-5DOI Listing
March 2006

Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752.

Proc Natl Acad Sci U S A 2006 Feb 6;103(7):2316-21. Epub 2006 Feb 6.

Cancer Center and Department of Pathology, Molecular Pathology Research Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1073/pnas.0508776103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413705PMC
February 2006

GAPs in growth factor signalling.

Growth Factors 2005 Jun;23(2):143-9

Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.

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http://www.tandfonline.com/doi/full/10.1080/0897719050013048
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http://dx.doi.org/10.1080/08977190500130480DOI Listing
June 2005