Jeffrey S Hyams

Jeffrey S Hyams

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Jeffrey S Hyams

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Serologic, but Not Genetic, Markers Are Associated With Impaired Anthropometrics at Diagnosis of Pediatric Crohn's Disease.

J Pediatr Gastroenterol Nutr 2019 Nov;69(5):e129-e134

Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition.

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http://dx.doi.org/10.1097/MPG.0000000000002462DOI Listing
November 2019

Longitudinal non-adherence predicts treatment escalation in paediatric ulcerative colitis.

Aliment Pharmacol Ther 2019 Oct 2;50(8):911-918. Epub 2019 Aug 2.

Cincinnati Children's Hospital Medical Center, Division of Behavioral Medicine and Clinical Psychology, Cincinnati, OH, USA.

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http://dx.doi.org/10.1111/apt.15445DOI Listing
October 2019

Characterizing Clinical Features and Creating a Gene Expression Profile Associated With Pain Burden in Children With Inflammatory Bowel Disease.

Inflamm Bowel Dis 2019 Oct 18. Epub 2019 Oct 18.

Department of Anesthesiology, University of Kansas School of Medicine, Kansas City, Kansas, USA.

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http://dx.doi.org/10.1093/ibd/izz240DOI Listing
October 2019

Special considerations for biologic medications in pediatric ulcerative colitis.

Expert Opin Biol Ther 2019 Oct 29:1-7. Epub 2019 Oct 29.

Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children's Medical Center, University of Connecticut School of Medicine, Hartford, USA.

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http://dx.doi.org/10.1080/14712598.2020.1685492DOI Listing
October 2019

Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy.

Cell 2019 Sep 29;178(6):1493-1508.e20. Epub 2019 Aug 29.

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.08.008DOI Listing
September 2019

Unlimited expansion of intestinal stem cells from a wide range of ages.

Integr Mol Med 2019 Aug 15;6(4). Epub 2019 Jul 15.

Institute of Molecular Medicine, McGovern Medical School of The University of Texas, Health Science Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.15761/IMM.1000375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713279PMC
August 2019

Health Care Cost for Children Newly Diagnosed With Inflammatory Bowel Disease.

Inflamm Bowel Dis 2019 Aug 24. Epub 2019 Aug 24.

Connecticut Children's Medical Center, Hartford, CT, USA.

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http://dx.doi.org/10.1093/ibd/izz183DOI Listing
August 2019

Blood-Derived DNA Methylation Signatures of Crohn's Disease and Severity of Intestinal Inflammation.

Gastroenterology 2019 06 16;156(8):2254-2265.e3. Epub 2019 Feb 16.

Genetics and Molecular Biology Program, Emory University, Atlanta, Georgia; Division of Pediatric Gastroenterology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia; Department of Human Genetics, Emory University, Atlanta, Georgia. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.01.270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529254PMC
June 2019

Bowel Location Rather Than Disease Subtype Dominates Transcriptomic Heterogeneity in Pediatric IBD.

Cell Mol Gastroenterol Hepatol 2018 1;6(4):474-476.e3. Epub 2018 Aug 1.

Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, Georgia.

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https://linkinghub.elsevier.com/retrieve/pii/S2352345X183010
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http://dx.doi.org/10.1016/j.jcmgh.2018.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198018PMC
April 2019

Population Pharmacokinetics and Exposure-Response Modeling Analyses of Golimumab in Children With Moderately to Severely Active Ulcerative Colitis.

J Clin Pharmacol 2019 Apr 11;59(4):590-604. Epub 2018 Dec 11.

Global Clinical Pharmacology, Janssen Research & Development, LLC, Spring House, PA, USA.

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http://dx.doi.org/10.1002/jcph.1353DOI Listing
April 2019

An Efficient Method for Cloning Gastrointestinal Stem Cells From Patients via Endoscopic Biopsies.

Gastroenterology 2019 01 6;156(1):20-23. Epub 2018 Oct 6.

Institute of Molecular Medicine, McGovern Medical School of University of Texas Health Science Center, Houston, Texas; Department of Biochemistry and Molecular Biology, McGovern Medical School of University of Texas Health Science Center, Houston, Texas. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085183508
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http://dx.doi.org/10.1053/j.gastro.2018.08.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309951PMC
January 2019

Safety of Adalimumab in Pediatric Patients with Polyarticular Juvenile Idiopathic Arthritis, Enthesitis-Related Arthritis, Psoriasis, and Crohn's Disease.

J Pediatr 2018 10 25;201:166-175.e3. Epub 2018 Jul 25.

Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children's Medical Center, Hartford, CT.

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http://dx.doi.org/10.1016/j.jpeds.2018.05.042DOI Listing
October 2018

Biologics Delay Progression of Crohn's Disease, but Not Early Surgery, in Children.

Clin Gastroenterol Hepatol 2018 09 2;16(9):1467-1473. Epub 2018 Mar 2.

Pediatric Gastroenterology and Nutrition, Hasbro Children Hospital, Providence, Rhode Island; The Warren Alpert Medical School, Brown University, Providence, Rhode Island. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2018.02.027DOI Listing
September 2018

Prevalence of Pediatric Functional Gastrointestinal Disorders Utilizing the Rome IV Criteria.

J Pediatr 2018 04 3;195:134-139. Epub 2018 Feb 3.

Department of Medicine, Division of Gastroenterology and Hepatology, Center for Functional GI and Motility Disorders, University of North Carolina, Chapel Hill, NC; College of Pharmacy and Health Sciences, Campbell University, Buies Creek, NC; School of Social Work, University of Washington, Seattle, WA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00223476173163
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http://dx.doi.org/10.1016/j.jpeds.2017.12.012DOI Listing
April 2018

Subcutaneous Golimumab in Pediatric Ulcerative Colitis: Pharmacokinetics and Clinical Benefit.

Inflamm Bowel Dis 2017 12;23(12):2227-2237

*Division of Gastroenterology, Hepatology, and Nutrition, Connecticut Children's Medical Center, Hartford, Connecticut;†Janssen Research & Development, LLC, Springhouse, Pennsylvania;‡The Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel;§IBD Centre, The Hospital for Sick Children, University of Toronto, Toronto, Canada;‖Pediatric Gastroenterology and Nutrition, University Hospital Brussels, Free University Brussels, Bruxelles, Belgium;¶Department of Pediatrics, University of California, San Francisco, California;**Pediatric Gastroenterology, Clinical Development and Research Affairs, Goryeb Children's Hospital/Atlantic Health, Morristown, New Jersey; and††Department of Pediatrics, Division of Gastroenterology, Seattle Children's Hospital, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1097/MIB.0000000000001262DOI Listing
December 2017

Combination Therapy in Pediatric Inflammatory Bowel Disease: Yes, No, Maybe.

Inflamm Bowel Dis 2017 10;23(10):1774-1776

*Division of Gastroenterology, Hepatology, and Nutrition, Connecticut Children's Medical Center, Hartford, Connecticut; †Division of Gastroenterology, Hepatology, and Nutrition, Mount Sinai Hospital, New York, New York; and ‡Division of Gastroenterology, Hepatology, and Nutrition, Emory University, Atlanta, Georgia.

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http://dx.doi.org/10.1097/MIB.0000000000001206DOI Listing
October 2017

Exclusive and partial enteral nutrition for Crohn's disease - Authors' reply.

Lancet 2017 09;390(10101):1486-1487

Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children's Medical Center, Hartford, CT, USA.

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http://dx.doi.org/10.1016/S0140-6736(17)32157-8DOI Listing
September 2017

Fecal Transplantation Successfully Treats Recurrent D-Lactic Acidosis in a Child With Short Bowel Syndrome.

JPEN J Parenter Enteral Nutr 2017 07 29;41(5):896-897. Epub 2015 Nov 29.

1 Division of Digestive Diseases, Hepatology & Nutrition, Connecticut Children's Medical Center, Hartford, Connecticut, USA.

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http://dx.doi.org/10.1177/0148607115619931DOI Listing
July 2017

Growth Improvement with Adalimumab Treatment in Children with Moderately to Severely Active Crohn's Disease.

Inflamm Bowel Dis 2017 06;23(6):967-975

*Department of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada; †Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN; ‡Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA; §Department of Pediatric Gastroenterology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands; ‖Department of Pediatrics, Pediatric Gastroenterology, Universite Sorbonne Paris-Cite, Hospital Necker-Enfants Malades, Paris, France; ¶Division of Digestive Diseases, Hepatology and Nutrition, Connecticut Children's Medical Center, Hartford, CT; **AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany; and ††AbbVie Inc., North Chicago, IL.

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http://dx.doi.org/10.1097/MIB.0000000000001075DOI Listing
June 2017

Long-term Efficacy and Safety of Adalimumab in Pediatric Patients with Crohn's Disease.

Inflamm Bowel Dis 2017 03;23(3):453-460

*Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; †Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York; ‡Pediatric Gastroenterology Unit, Department of Pediatrics, Universite Sorbonne Paris-Cite, Hospital Necker-Enfants Malades, Paris, France; §Department of Pediatric Gastroenterology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands; ‖Pediatric Gastroenterology, Goryeb Children's Hospital/Atlantic Health, Morristown, New Jersey; ¶Division of Digestive Diseases, Connecticut Children's Medical Center, Hartford, Connecticut; **AbbVie Inc., North Chicago, Illinois; and ††AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany.

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http://dx.doi.org/10.1097/MIB.0000000000001021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319394PMC
March 2017

Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease.

Gastroenterology 2017 01 28;152(1):206-217.e2. Epub 2016 Sep 28.

Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.09.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164948PMC
January 2017

The safety of treatment options for pediatric Crohn's disease.

Expert Opin Drug Saf 2016 Oct 1;15(10):1383-90. Epub 2016 Jul 1.

a Division of Digestive Diseases, Hepatology, and Nutrition , Connecticut Children's Medical Center , Hartford , CT , USA.

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http://dx.doi.org/10.1080/14740338.2016.1203418DOI Listing
October 2016

Multi-Center Experience of Vedolizumab Effectiveness in Pediatric Inflammatory Bowel Disease.

Inflamm Bowel Dis 2016 09;22(9):2121-6

*Department of Pediatrics, Pediatric Inflammatory Bowel Disease Program, Cedars Sinai Medical Center, Los Angeles, California; †Department of Pediatrics, Susan and Leonard Feinstein IBD Clinical Center, Icahn School of Medicine, Mount Sinai Hospital, New York, New York; and ‡Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children's Medical Center, Hartford, CT; University of Connecticut School of Medicine, Farmington, Connecticut.

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http://www.wcpghan2016.com/Presentations/8-Saturday/AM/517D/
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http://pdfs.journals.lww.com/ibdjournal/2016/09000/Multi_Cen
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http://dx.doi.org/10.1097/MIB.0000000000000865DOI Listing
September 2016

Efficacy and Safety of Escalation of Adalimumab Therapy to Weekly Dosing in Pediatric Patients with Crohn's Disease.

Inflamm Bowel Dis 2016 Apr;22(4):886-93

*Pediatric Gastroenterology and Hepatology, Icahn School of Medicine at Mount Sinai, New York, New York; †Division of Gastroenterology and Nutrition, Goryeb Children's Hospital/Atlantic Health, Morristown, New Jersey; ‡Gastroentrology and Hepatology, Mayo Clinic, Rochester, Minnesota; §Department of Gastroenterology, Hepatology and Feeding Disorders, Children's Memorial Health Institute, Warsaw, Poland; ‖Faculté de Médecine, Universite Paris Descartes, Sorbonne Paris-Cite and Department of Paediatric Gastroenterology, APHP Hopital Necker-Enfants Malades, Paris, France; ¶Digestive Diseases, Hepatology and Nutrition, Connecticut Children's Medical Center, Hartford, Connecticut; **US Medical Affairs, AbbVie Inc., North Chicago, Illinois; ††Data and Statistical Sciences, AbbVie Inc., North Chicago, Illinois; ‡‡Clinical Pharmacology & Pharmacometrics, AbbVie Inc., North Chicago, Illinois; §§AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany; and ‖‖Global Regulatory Affairs, AbbVie Inc., North Chicago, Illinois.

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http://dx.doi.org/10.1097/MIB.0000000000000715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794130PMC
April 2016

Functional Disorders: Children and Adolescents.

Gastroenterology 2016 Feb 15. Epub 2016 Feb 15.

University of North Carolina at Chapel Hill Department of Gastroenterology and Hepatology 130 Mason Farm rd, #4106 CB 7080 Chapel Hill NC.

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http://dx.doi.org/10.1053/j.gastro.2016.02.015DOI Listing
February 2016

Can early anti-TNF-α treatment be an effective therapeutic strategy in children with Crohn's disease?

Immunotherapy 2014 ;6(7):799-802

Division of Digestive Diseases, Hepatology, and Nutrition Connecticut Children's Medical Center Professor of Pediatrics, University of Connecticut School of Medicine, CT, USA.

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http://dx.doi.org/10.2217/imt.14.57DOI Listing
July 2015

Well-defined and reliable clinical outcome assessments for pediatric Crohn disease: a critical need for drug development.

J Pediatr Gastroenterol Nutr 2015 Jun;60(6):729-36

*Office of Pediatric Therapeutics, Office of the Commissioner, Food and Drug Administration †Study Endpoint and Labeling Development, Office of New Drugs, Center for Drug Research and Evaluation, Food and Drug Administration, Silver Spring, MD ‡Connecticut Children's Medical Center, Hartford §Division of Gastroenterology and Inborn Errors Products, Office of New Drug, Center for Drug Research and Evaluation, Food and Drug Administration, Silver Spring, MD.

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http://dx.doi.org/10.1097/MPG.0000000000000793DOI Listing
June 2015

Cloning and variation of ground state intestinal stem cells.

Nature 2015 Jun 3;522(7555):173-8. Epub 2015 Jun 3.

1] The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut 06032, USA [2] Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06032, USA [3] Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02118, USA [4] Department of Medicine, National University of Singapore, 119228 Singapore [5] Multiclonal Therapeutics, Inc., Farmington, Connecticut 06032, USA.

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http://dx.doi.org/10.1038/nature14484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853906PMC
June 2015

Pharmacokinetics and exposure-efficacy relationship of adalimumab in pediatric patients with moderate to severe Crohn's disease: results from a randomized, multicenter, phase-3 study.

Inflamm Bowel Dis 2015 Apr;21(4):783-92

*Global Pharmaceutical Research and Development Division, AbbVie Inc., North Chicago, Illinois; †AbbVie Deutschland GmbH & Co KG, Ludwigshafen, Germany; ‡Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children's Medical Center, Hartford, Connecticut; §Division of Gastroenterology and Nutrition, Goryeb Children's Hospital-Atlantic Health, Morristown, New Jersey; and ‖Service de gastroentérologie-hépatologie-nutrition pédiatriques, Hôpital Necker-Enfants Malades, Paris, France.

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http://dx.doi.org/10.1097/MIB.0000000000000327DOI Listing
April 2015

Difficult-to-treat-pediatric Crohn's disease: focus on adalimumab.

Pediatric Health Med Ther 2015 28;6:33-40. Epub 2015 Apr 28.

Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children's Medical Center Hartford, University of Connecticut School of Medicine, Department of Pediatrics, Farmington, CT, USA.

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http://dx.doi.org/10.2147/PHMT.S40948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683269PMC
April 2015

Outcome measures for clinical trials in paediatric IBD: an evidence-based, expert-driven practical statement paper of the paediatric ECCO committee.

Gut 2015 Mar 12;64(3):438-46. Epub 2014 May 12.

The Juliet Keidan Institute for Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Israel.

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http://dx.doi.org/10.1136/gutjnl-2014-307008DOI Listing
March 2015

Standardized recording of parameters related to the natural history of inflammatory bowel disease: from Montreal to Paris.

Authors:
Jeffrey S Hyams

Dig Dis 2014 23;32(4):337-44. Epub 2014 Jun 23.

Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children's Medical Center, University of Connecticut School of Medicine, Hartford, Conn., USA.

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http://dx.doi.org/10.1159/000358133DOI Listing
February 2015

Biologics in pediatric Crohn's disease: is it time to move to an earlier therapeutic approach?

Authors:
Jeffrey S Hyams

Expert Rev Clin Immunol 2014 Nov;10(11):1423-6

Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children's Medical Center, Professor of Pediatrics, University of Connecticut School of Medicine, 282 Washington Street, Hartford, CT 06106, USA.

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http://dx.doi.org/10.1586/1744666X.2014.955017DOI Listing
November 2014

Retrospective cohort study of methotrexate use in the treatment of pediatric Crohn's disease.

Inflamm Bowel Dis 2014 Aug;20(8):1341-5

1Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania; 2Department of Pediatrics, Connecticut Children's Medical Center, Hartford, Connecticut; 3Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada; 4Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, Toronto, ON, Canada; 5Department of Pediatrics, I.W.K. Health Center, Halifax, NS, Canada; 6Pediatric Gastroenterology, Goryeb Children's Hospital, Morristown, New Jersey; 7Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio; 8Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; 9Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin; 10Section of Gastroenterology/Hepatology/Nutrition, Riley Hospital for Children, Indianapolis, Indiana; 11Department of Gastroenterology, Dayton Children's, Dayton, Ohio; 12Division of Pediatric Gastroenterology, Nutrition and Liver Diseases, Hasbro Children's Hospital, Providence, Rhode Island; 13Department of Pediatrics, Russell Children's Hospital, Birmingham, Alabama; 14Division of Pediatric Gastroenterology and Nutrition, Johns Hopkins University School of Medicine, Baltimore, Maryland; 15Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Medical Center, Cincinnati, Ohio; 16Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina; and 17Department of Pediatrics, Cohen Children's Medical Center, New Hyde Park, New York.

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http://dx.doi.org/10.1097/MIB.0000000000000102DOI Listing
August 2014

Treating inflammatory bowel disease in children and adolescents.

Authors:
Jeffrey S Hyams

Gastroenterol Hepatol (N Y) 2014 Jul;10(7):444-6

Director Department of Gastroenterology Connecticut Children's Medical Center Professor Department of Pediatrics University of Connecticut School of Medicine Hartford, Connecticut.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302493PMC
July 2014

Pediatric UC drug development: a GREAT idea now needs a GRAND conversation.

J Pediatr Gastroenterol Nutr 2014 Jun;58(6):677-8

*Pediatric Gastroenterology, Goryeb Children's Hospital, Atlantic Health, Morristown, NJ †Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children's Medical Center, Hartford.

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http://dx.doi.org/10.1097/MPG.0000000000000367DOI Listing
June 2014

Utility of neutrophil Fcγ receptor I (CD64) index as a biomarker for mucosal inflammation in pediatric Crohn's disease.

Inflamm Bowel Dis 2014 Jun;20(6):1037-48

1Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Divisions of 2Allergy and Immunology and 3Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; 4Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; 5Division of Pediatric Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; 6Division of Pediatric Gastroenterology and Nutrition, Cohen Children's Medical Center of New York, New Hyde Park, New York; 7Department of Pediatric Gastroenterology and Nutrition, Goryeb Children's Hospital/Atlantic Health System, Morristown, New Jersey; 8Division of Pediatric Gastroenterology, Hepatology and Nutrition, Nationwide Children's Hospital, Columbus, Ohio; 9Department of Pediatrics, University of California, San Francisco, San Francisco, California; 10Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada; 11Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada; 12Digestive Diseases and Nutrition Center, Department of Pediatrics, University at Buffalo, Buffalo, New York; 13Division of Digestive Diseases and Nutrition, Connecticut Children's Medical Center, Hartford, Connecticut; and 14Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Emory University, Atlanta, Georgia.

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http://dx.doi.org/10.1097/MIB.0000000000000049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151275PMC
June 2014

Transition of management in adolescents with IBD.

Nat Rev Gastroenterol Hepatol 2014 Feb 14;11(2):109-15. Epub 2014 Jan 14.

Division of Digestive Diseases, Hepatology & Nutrition, Connecticut Children's Medical Center, 282 Washington Street, Hartford, CT 06106, USA.

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http://dx.doi.org/10.1038/nrgastro.2013.254DOI Listing
February 2014

Fecal transplantation: re-discovering the value of stool.

Curr Opin Pediatr 2013 Oct;25(5):618-23

Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children's Medical Center, Hartford CT, University of Connecticut School of Medicine, Farmington, Connecticut, USA.

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http://dx.doi.org/10.1097/MOP.0b013e328363ed66DOI Listing
October 2013

Authors' response.

J Pediatr Gastroenterol Nutr 2013 May;56(5):e38

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http://dx.doi.org/10.1097/MPG.0b013e318289530aDOI Listing
May 2013

Fecal osteoprotegerin may guide the introduction of second-line therapy in hospitalized children with ulcerative colitis.

Inflamm Bowel Dis 2011 Aug 3;17(8):1726-30. Epub 2010 Dec 3.

Division of Digestive Diseases, Hepatology and Nutrition, Connecticut Children's Medical Center, Hartford, Connecticut, USA.

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http://dx.doi.org/10.1002/ibd.21561DOI Listing
August 2011

The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organisation: pregnancy and pediatrics.

Am J Gastroenterol 2011 Feb 14;106(2):214-23; quiz 224. Epub 2010 Dec 14.

Department of Gastroenterology, UCSF Center for Colitis and Crohn's Disease, San Francisco, California 94115, USA.

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http://dx.doi.org/10.1038/ajg.2010.464DOI Listing
February 2011

Retrospective Evaluation of the Safety and Effect of Adalimumab Therapy (RESEAT) in pediatric Crohn's disease.

Am J Gastroenterol 2009 Dec 1;104(12):3042-9. Epub 2009 Sep 1.

Division of Pediatric Gastroenterology, Goryeb Children's Hospital/Atlantic Health, Morristown, New Jersey 07962 , USA.

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http://dx.doi.org/10.1038/ajg.2009.493DOI Listing
December 2009

Risk/benefit strategies must be employed in the management of pediatric Crohn's disease.

Authors:
Jeffrey S Hyams

Dig Dis 2009 24;27(3):291-6. Epub 2009 Sep 24.

Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children's Medical Center, University of Connecticut School of Medicine, Hartford, CT 06106, USA.

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http://dx.doi.org/10.1159/000228563DOI Listing
December 2009

A two-year longitudinal study of persistent lean tissue deficits in children with Crohn's disease.

Clin Gastroenterol Hepatol 2009 Apr 27;7(4):452-5. Epub 2008 Dec 27.

Connecticut Children's Medical Center, Hartford, Connecticut 06106, USA.

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http://dx.doi.org/10.1016/j.cgh.2008.12.017DOI Listing
April 2009

Organization of a research consortium: the time is now.

Authors:
Jeffrey S Hyams

J Pediatr Gastroenterol Nutr 2008 Nov;47(5):713-5

Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children's Medical Center, Hartford, CT 06106, USA.

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http://dx.doi.org/10.1097/01.mpg.0000338971.57088.c0DOI Listing
November 2008

Is hypnotherapy effective for pediatric functional abdominal pain or IBS?

Authors:
Jeffrey S Hyams

Nat Clin Pract Gastroenterol Hepatol 2008 Jun 15;5(6):300-1. Epub 2008 Apr 15.

Connecticut Children's Medical Center, Hartford, CT 06106, USA.

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http://dx.doi.org/10.1038/ncpgasthep1126DOI Listing
June 2008

Diagnosis and management of inflammatory bowel disease in children.

Semin Pediatr Surg 2007 Aug;16(3):164-71

Children's Medical Center, Wright University and Boonshoft School of Medicine, Dayton, Ohio, USA.

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http://dx.doi.org/10.1053/j.sempedsurg.2007.04.003DOI Listing
August 2007

Natalizumab therapy for moderate to severe Crohn disease in adolescents.

J Pediatr Gastroenterol Nutr 2007 Feb;44(2):185-91

Division of Digestive Diseases and Nutrition, Connecticut Children's Medical Center, Hartford, CT 06106, USA.

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http://dx.doi.org/10.1097/01.mpg.0000252191.05170.e7DOI Listing
February 2007

Natural history of bone metabolism and bone mineral density in children with inflammatory bowel disease.

Inflamm Bowel Dis 2007 Jan;13(1):42-50

Division of Gastroenterology and Nutrition, Connecticut Children's Medical Center, Hartford, Connecticut 06106, USA.

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http://dx.doi.org/10.1002/ibd.20006DOI Listing
January 2007

Are activated T cells regulators of bone metabolism in children with Crohn disease?

J Pediatr 2006 Apr;148(4):461-6

Connecticut Children's Medical Center, Saint Francis Hospital & Medical Center, Hartford 06106, and University of Connecticut School of Medicine, Farmington, Connecticut, USA.

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http://dx.doi.org/10.1016/j.jpeds.2005.12.027DOI Listing
April 2006

Childhood functional gastrointestinal disorders: child/adolescent.

Gastroenterology 2006 Apr;130(5):1527-37

Division of Pediatric Gastroenterology and Nutrition, CHU Ste Justine, University of Montreal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1053/j.gastro.2005.08.063DOI Listing
April 2006

Treatment of functional gastrointestinal disorders associated with abdominal pain.

Authors:
Jeffrey S Hyams

J Pediatr Gastroenterol Nutr 2005 Sep;41 Suppl 1:S47-8

Division of Digestive Diseases and Nutrition, Connecticut Children's Medical Center, Hartford, Connecticut, USA.

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http://dx.doi.org/10.1097/01.scs.0000180303.71557.71DOI Listing
September 2005

Inflammatory bowel disease.

Authors:
Jeffrey S Hyams

Pediatr Rev 2005 Sep;26(9):314-20

Division of Digestive Diseases and Nutrition, Connecticut Children's Medical Center, Hartford, Conn, USA.

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http://dx.doi.org/10.1542/pir.26-9-314DOI Listing
September 2005

Can we alter the natural history of Crohn disease in children?

J Pediatr Gastroenterol Nutr 2005 Mar;40(3):262-72

Division of Digestive Diseases and Nutrition, Connecticut Children's Medical Center, Hartford, CT 06106, USA.

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http://dx.doi.org/10.1097/01.mpg.0000154660.62359.feDOI Listing
March 2005