Jeffrey S Barrett

Jeffrey S Barrett

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Jeffrey S Barrett

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Real-World Data: An Unrealized Opportunity in Global Health?

Clin Pharmacol Ther 2019 Jul 12;106(1):57-59. Epub 2019 Jun 12.

Bill & Melinda Gates Medical Research Institute, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1002/cpt.1476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771465PMC
July 2019

A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children.

AAPS J 2019 06 27;21(5):81. Epub 2019 Jun 27.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1208/s12248-019-0351-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597607PMC
June 2019

Challenges and Opportunities With Oncology Drug Development in China.

Clin Pharmacol Ther 2019 02 8;105(2):363-375. Epub 2018 Mar 8.

Bristol-Myers Squibb, Princeton, New Jersey, USA.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cpt.1017
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http://dx.doi.org/10.1002/cpt.1017DOI Listing
February 2019

Antiinflammatory effects of aprepitant coadministration with cART regimen containing ritonavir in HIV-infected adults.

JCI Insight 2017 10 5;2(19). Epub 2017 Oct 5.

Department of Pediatrics, Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/jci.insight.95893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841871PMC
October 2017

Linear-In-Flux-Expressions Methodology: Toward a Robust Mathematical Framework for Quantitative Systems Pharmacology Simulators.

Gene Regul Syst Bio 2017 26;11:1177625017711414. Epub 2017 Jul 26.

Translational Informatics Department, Sanofi US, Bridgewater, NJ, USA.

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http://dx.doi.org/10.1177/1177625017711414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862386PMC
July 2017

Safety, dosing, and pharmaceutical quality for studies that evaluate medicinal products (including biological products) in neonates.

Pediatr Res 2017 May 3;81(5):692-711. Epub 2016 Nov 3.

Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1038/pr.2016.221DOI Listing
May 2017

Exposure Matching for Extrapolation of Efficacy in Pediatric Drug Development.

J Clin Pharmacol 2016 11;56(11):1326-1334

Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.

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http://dx.doi.org/10.1002/jcph.744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482171PMC
November 2016

Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV.

J Transl Med 2016 05 26;14(1):148. Epub 2016 May 26.

Division of Allergy and Immunology, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1186/s12967-016-0904-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880976PMC
May 2016

Population pharmacokinetics of midazolam and its metabolites in overweight and obese adolescents.

Br J Clin Pharmacol 2015 Nov 10;80(5):1185-96. Epub 2015 Sep 10.

Division of Clinical Pharmacology, Children's National Medical Center, Washington DC, USA.

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http://dx.doi.org/10.1111/bcp.12693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631191PMC
November 2015

Malabsorption blood test: Assessing fat absorption in patients with cystic fibrosis and pancreatic insufficiency.

J Clin Pharmacol 2015 Aug 23;55(8):854-65. Epub 2015 Mar 23.

Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/jcph.484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496318PMC
August 2015

Population Pharmacokinetic Model of Sublingual Buprenorphine in Neonatal Abstinence Syndrome.

Pharmacotherapy 2015 Jul 14;35(7):670-80. Epub 2015 Jul 14.

Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/phar.1610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119858PMC
July 2015

Evaluation of sodium nitroprusside for controlled hypotension in children during surgery.

Front Pharmacol 2015 6;6:136. Epub 2015 Jul 6.

Department of Anesthesia and Perioperative Care, University of California, San Francisco San Francisco, CA, USA.

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http://dx.doi.org/10.3389/fphar.2015.00136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491614PMC
July 2015

ABCB1 polymorphism and gender affect the pharmacokinetics of amlodipine in Chinese patients with essential hypertension: a population analysis.

Drug Metab Pharmacokinet 2014 11;29(4):305-11. Epub 2014 Feb 11.

Center of Clinical Pharmacology and Pharmacy Department, The Third Xiangya Hospital, Central South University.

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http://dx.doi.org/10.2133/dmpk.dmpk-13-rg-127DOI Listing
May 2015

Reduction of soluble CD163, substance P, programmed death 1 and inflammatory markers: phase 1B trial of aprepitant in HIV-1-infected adults.

AIDS 2015 May;29(8):931-9

aDepartment of Medicine bDepartment of Pediatrics cDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania dThe Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania eWestat, Rockville, Maryland, USA.

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http://dx.doi.org/10.1097/QAD.0000000000000638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472318PMC
May 2015

Novel method to predict body weight in children based on age and morphological facial features.

J Clin Pharmacol 2015 Apr 6;55(4):447-51. Epub 2015 Jan 6.

Division of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://doi.wiley.com/10.1002/jcph.422
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http://dx.doi.org/10.1002/jcph.422DOI Listing
April 2015

Modeling and simulation approach to support dosing and study design requirements for treating HIV-related neuropsychiatric disease with the NK1-R antagonist aprepitant.

Curr HIV Res 2014 ;12(2):121-31

Divisions of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.2174/1570162x12666140526120831DOI Listing
March 2015

Challenges and considerations for development of therapeutic proteins in pediatric patients.

J Clin Pharmacol 2015 Mar;55 Suppl 3:S103-15

Former employee of Clinical Pharmacology, Genentech, South San Francisco, USA; Oncology Clinical Pharmacology, Novartis, East Hanover, USA.

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http://dx.doi.org/10.1002/jcph.382DOI Listing
March 2015

Paediatric models in motion: requirements for model-based decision support at the bedside.

Br J Clin Pharmacol 2015 Jan;79(1):85-96

Department of Pediatrics, Division of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/bcp.12287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294079PMC
January 2015

Adjuvant therapies for HIV-associated neurocognitive disorders.

Ann Clin Transl Neurol 2014 Nov 23;1(11):938-52. Epub 2014 Oct 23.

The Children's Hospital of Philadelphia Research Institute Philadelphia, Pennsylvania ; Division of Allergy & Immunology, The Children's Hospital of Philadelphia Philadelphia, Pennsylvania ; Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1002/acn3.131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265066PMC
November 2014

Predictors of arterial blood pressure control during deliberate hypotension with sodium nitroprusside in children.

Anesth Analg 2014 Oct;119(4):867-74

From the *Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina; †Department of Pediatrics, University of Pennsylvania Medical School, Philadelphia, Pennsylvania; ‡Department of Anesthesia, Stanford School of Medicine, Stanford, California; and §Duke Clinical Research Institute, Durham, North Carolina.

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http://dx.doi.org/10.1213/ANE.0000000000000376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169308PMC
October 2014

Effect of CYP3A5*3 polymorphism on pharmacokinetic drug interaction between tacrolimus and amlodipine.

Drug Metab Pharmacokinet 2013 26;28(5):398-405. Epub 2013 Feb 26.

Clinical Pharmacy and Pharmacology Research Institute, The Third Xiangya Hospital, Central South University.

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http://dx.doi.org/10.2133/dmpk.dmpk-12-rg-148DOI Listing
June 2014

Busulfan in infant to adult hematopoietic cell transplant recipients: a population pharmacokinetic model for initial and Bayesian dose personalization.

Clin Cancer Res 2014 Feb 11;20(3):754-63. Epub 2013 Nov 11.

Authors' Affiliations: University of Washington Schools of Pharmacy and Medicine; Fred Hutchinson Cancer Research Center; Seattle Children's Hospital, Seattle, Washington; Division of Clinical Pharmacology & Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Children's Mercy Hospitals and Clinics, Kansas City, Missouri; and Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946385PMC
February 2014

A sensitive and selective liquid chromatography/tandem mass spectrometry method for quantitative analysis of efavirenz in human plasma.

PLoS One 2013 5;8(6):e63305. Epub 2013 Jun 5.

Division of Clinical Pharmacology & Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063305PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673986PMC
January 2014

The grand challenges in obstetric and pediatric pharmacology.

Front Pharmacol 2013 30;4:170. Epub 2013 Dec 30.

Interdisciplinary Pharmacometrics Program, Pediatric Clinical Pharmacology Sanofi, Philadelphia, PA, USA.

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http://dx.doi.org/10.3389/fphar.2013.00170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874543PMC
January 2014

PET measurement of receptor occupancy as a tool to guide dose selection in neuropharmacology: are we asking the right questions?

J Clin Psychopharmacol 2013 Dec;33(6):725-8

From the *Laboratory for Applied PK/PD, Division of Clinical Pharmacology and Therapeutics, Divisions of †Neurology, and ‡Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA.

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http://dx.doi.org/10.1097/JCP.0b013e3182a88654DOI Listing
December 2013

Identifying novel phenotypes of vulnerability and resistance to activity-based anorexia in adolescent female rats.

Int J Eat Disord 2013 Nov 13;46(7):737-46. Epub 2013 Jul 13.

Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York; Department of Psychiatry, New York State Psychiatric Institute, New York.

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http://dx.doi.org/10.1002/eat.22149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783190PMC
November 2013

GCG100649, A Novel Cyclooxygenase-2 Inhibitor, Exhibits a Drug Disposition Profile in Healthy Volunteers Compatible With High Affinity to Carbonic Anhydrase-I/II: Preliminary Dose-Exposure Relationships to Define Clinical Development Strategies.

Clin Pharmacol Drug Dev 2013 Oct 25;2(4):379-86. Epub 2013 Jul 25.

Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/cpdd.47DOI Listing
October 2013

A Modeling and Simulations Framework to Support Global Regulatory Strategies for Pediatric Drug Development Programs.

Ther Innov Regul Sci 2013 Sep;47(5):550-556

3 The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1177/2168479013500289DOI Listing
September 2013

Considerations for the prediction of survival time in pancreatic cancer based on registry data.

J Pharmacokinet Pharmacodyn 2013 Aug 12;40(4):527-36. Epub 2013 Jul 12.

Laboratory of Applied PK/PD, Department of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia, Colket Translational Research Building, Room 4012, 3501 Civic Center Blvd, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s10928-013-9327-zDOI Listing
August 2013

Risk assessment of drug interaction potential and concomitant dosing pattern on targeted toxicities in pediatric cancer patients.

AAPS J 2013 Jul 18;15(3):775-86. Epub 2013 Apr 18.

Division of Clinical Pharmacology and Therapeutics, Department of Pediatrics, The Children's Hospital of Philadelphia, 3501 Civic Center Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1208/s12248-013-9489-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691430PMC
July 2013

Strategic biomarkers for drug development in treating rare diseases and diseases in neonates and infants.

AAPS J 2013 Apr 19;15(2):447-54. Epub 2013 Jan 19.

Office of Clinical Pharmacology, Center for Drug Evaluation and Research, FDA, Silver Spring, MD, USA.

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http://dx.doi.org/10.1208/s12248-013-9452-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675740PMC
April 2013

Increased bioavailability of 11-keto-β-boswellic acid following single oral dose frankincense extract administration after a standardized meal in healthy male volunteers: modeling and simulation considerations for evaluating drug exposures.

J Clin Pharmacol 2012 Oct 13;52(10):1592-600. Epub 2011 Dec 13.

Institute for Translational Medicine and Therapeutics (ITMAT), Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1177/0091270011422811DOI Listing
October 2012

Modeling and simulation approaches to evaluate pharmacokinetic sampling contamination from central venous catheters in pediatric pharmacokinetic studies of actinomycin-D: a report from the children's oncology group.

Cancer Chemother Pharmacol 2012 Jul 24;70(1):83-94. Epub 2012 May 24.

Division of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia, Colket Translational Research Building, Room 4012, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s00280-012-1878-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008333PMC
July 2012

Melatonin pharmacokinetics following two different oral surge-sustained release doses in older adults.

J Pineal Res 2012 May 21;52(4):437-45. Epub 2012 Feb 21.

Division of Geriatric Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://doi.wiley.com/10.1111/j.1600-079X.2011.00958.x
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http://dx.doi.org/10.1111/j.1600-079X.2011.00958.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682489PMC
May 2012

Clinical importance of the drug interaction between statins and CYP3A4 inhibitors: a retrospective cohort study in The Health Improvement Network.

Pharmacoepidemiol Drug Saf 2012 May 16;21(5):494-506. Epub 2012 Mar 16.

Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/pds.3199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890414PMC
May 2012

Population pharmacokinetics of pentobarbital in neonates, infants, and children after open heart surgery.

J Pediatr 2011 Sep 12;159(3):414-419.e1-3. Epub 2011 Jun 12.

Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002234761100390
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http://dx.doi.org/10.1016/j.jpeds.2011.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157563PMC
September 2011

Dactinomycin and vincristine toxicity in the treatment of childhood cancer: a retrospective study from the Children's Oncology Group.

Pediatr Blood Cancer 2011 Aug 1;57(2):252-7. Epub 2010 Dec 1.

Children's Oncology Group and Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1002/pbc.22882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467305PMC
August 2011

A time to keep and a time to cast away categories of tumor response.

J Clin Oncol 2011 Aug 5;29(23):3109-11. Epub 2011 Jul 5.

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http://dx.doi.org/10.1200/JCO.2011.36.3887DOI Listing
August 2011

Prescribing habits and caregiver satisfaction with resources for dosing children: rationale for more informative dosing guidance.

BMC Pediatr 2011 Apr 2;11:25. Epub 2011 Apr 2.

Department of Pediatrics, Division of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia, 3501 Civic Center Blvd, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1186/1471-2431-11-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076266PMC
April 2011

Evaluating performance of a decision support system to improve methotrexate pharmacotherapy in children and young adults with cancer.

Ther Drug Monit 2011 Feb;33(1):99-107

Laboratory for Applied PK/PD, Division of Clinical Pharmacology & Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1097/FTD.0b013e318203b41eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074357PMC
February 2011

Approaches to clear residual chemotherapeutics from indwelling catheters in children with cancer.

Ther Drug Monit 2010 Dec;32(6):741-8

Division of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1097/FTD.0b013e3181fa3c68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998595PMC
December 2010

Application of Individualized Bayesian Urea Kinetic Modeling to pediatric hemodialysis.

ASAIO J 2010 May-Jun;56(3):246-53

Laboratory for Applied PK/PD, Division of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1097/MAT.0b013e3181cf07d2DOI Listing
August 2010

Population pharmacokinetics of dexmedetomidine in infants after open heart surgery.

Anesth Analg 2010 May;110(5):1383-92

Division of Clinical Pharmacology and Therapeutics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1213/ANE.0b013e3181d783c8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041635PMC
May 2010

A rapid and sensitive LC-MS/MS method for determination of fluconazole in human plasma and its application in infants with Candida infections.

Ther Drug Monit 2009 Dec;31(6):703-9

Laboratory for Applied PK/PD, Division of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://Insights.ovid.com/crossref?an=00007691-200912000-0000
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http://dx.doi.org/10.1097/FTD.0b013e3181b20b40DOI Listing
December 2009

The in silico child: using simulation to guide pediatric drug development and manage pediatric pharmacotherapy.

J Clin Pharmacol 2009 Aug 16;49(8):889-904. Epub 2009 Jun 16.

Department of Clinical Pharmacy and Pharmacotherapy, Heinrich-Heine-University of Düsseldorf, 40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1177/0091270009337513DOI Listing
August 2009

Population pharmacokinetics of the selective serotonin 5-HT1A receptor partial agonist piclozotan.

Am J Ther 2009 Mar-Apr;16(2):106-15

Department of Pediatrics, Division of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia, PA, USA.

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http://dx.doi.org/10.1097/MJT.0b013e31816b8c85DOI Listing
May 2009

Rhabdomyolysis reports show interaction between simvastatin and CYP3A4 inhibitors.

Pharmacoepidemiol Drug Saf 2009 Apr;18(4):301-9

Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1002/pds.1711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890413PMC
April 2009

Population pharmacokinetics of imatinib mesylate and its metabolite in children and young adults.

Cancer Chemother Pharmacol 2009 Jan 9;63(2):229-38. Epub 2008 Apr 9.

The Children's Hospital of Philadelphia, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s00280-008-0730-xDOI Listing
January 2009

The role of quantitative pharmacology in an academic translational research environment.

AAPS J 2008 5;10(1):9-14. Epub 2008 Feb 5.

Laboratory for Applied PK/PD, Clinical Pharmacology & Therapeutics Division, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1208/s12248-007-9002-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751447PMC
September 2008

Globalization of quantitative pharmacology: first international symposium of quantitative pharmacology in drug development and regulation.

J Clin Pharmacol 2008 Jul 19;48(7):787-92. Epub 2008 May 19.

Laboratory for Applied PK/PD, Clinical Pharmacology & Therapeutics Division, The Children's Hospital of Philadelphia, The University of Pennsylvania Medical School, Pediatrics Department, Abramson Research Center, Philadelphia, PA 19104, USA.

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http://doi.wiley.com/10.1177/0091270008319331
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http://dx.doi.org/10.1177/0091270008319331DOI Listing
July 2008

Key performance indicators for the assessment of pediatric pharmacotherapeutic guidance.

J Pediatr Pharmacol Ther 2008 Jul;13(3):141-55

Laboratory for Applied Pharmacokinetics/Pharmacodynamics, Division of Clinical Pharmacology, The Children's Hospital of Philadelphia ; Pediatrics Department, University of Pennsylvania Medical School.

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http://dx.doi.org/10.5863/1551-6776-13.3.141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462038PMC
July 2008

A SAS-based solution to evaluate study design efficiency of phase I pediatric oncology trials via discrete event simulation.

Comput Methods Programs Biomed 2008 Jun 13;90(3):240-50. Epub 2008 Feb 13.

Clinical Pharmacology & Therapeutics Division, The Children's Hospital of Philadelphia, USA.

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http://dx.doi.org/10.1016/j.cmpb.2007.12.008DOI Listing
June 2008

Abundant anti-apoptotic BCL-2 is a molecular target in leukaemias with t(4;11) translocation.

Br J Haematol 2008 Jun 18;141(6):827-39. Epub 2008 Apr 18.

Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2008.07100.xDOI Listing
June 2008

Pharmacokinetics and pharmacodynamics in the critically ill child.

Pediatr Clin North Am 2008 Jun;55(3):735-55, xii

The Children's Hospital of Philadelphia, Abramson Research Center, 3516 Civic Center Boulevard, Suite 916 H, Philadelphia, PA 19104, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S003139550800090
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http://dx.doi.org/10.1016/j.pcl.2008.02.017DOI Listing
June 2008

Pharmacometrics: a multidisciplinary field to facilitate critical thinking in drug development and translational research settings.

J Clin Pharmacol 2008 May;48(5):632-49

Laboratory for Applied PK/PD, Clinical Pharmacology & Therapeutics Division, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1177/0091270008315318DOI Listing
May 2008

All dex'ed out with nowhere to go?

J Clin Oncol 2008 Apr;26(12):1917-8

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http://dx.doi.org/10.1200/JCO.2007.15.4591DOI Listing
April 2008

Clinical and pharmacokinetic characteristics of intracavitary administration of pegylated liposomal encapsulated doxorubicin in dogs with splenic hemangiosarcoma.

J Vet Intern Med 2007 Nov-Dec;21(6):1347-54

School of Veterinary Medicine, Department of Clinical Studies, MJ Ryan Veterinary Hospital of the University of Pennsylvania, 3900 Delancy Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1892/06-214.1DOI Listing
February 2008

Population pharmacokinetic investigation of actinomycin-D in children and young adults.

J Clin Pharmacol 2008 Jan;48(1):35-42

Division of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://doi.wiley.com/10.1177/0091270007310383
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http://dx.doi.org/10.1177/0091270007310383DOI Listing
January 2008

Shortening the timeline of pediatric phase I trials: the rolling six design.

J Clin Oncol 2008 Jan;26(2):190-5

Children's Hospital of Philadelphia, Abramson Research Center 916, 3615 Civic Center Blvd, Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1200/JCO.2007.12.7712DOI Listing
January 2008

Integration of modeling and simulation into hospital-based decision support systems guiding pediatric pharmacotherapy.

BMC Med Inform Decis Mak 2008 Jan 28;8. Epub 2008 Jan 28.

Department of Pediatrics, Division of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia, USA.

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http://bmcmedinformdecismak.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/1472-6947-8-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2254609PMC
January 2008

An informatics approach to assess pediatric pharmacotherapy: design and implementation of a hospital drug utilization system.

J Clin Pharmacol 2007 Sep 26;47(9):1172-80. Epub 2007 Jul 26.

Clinical Pharmacology and Therapeutics, Abramson Research Center, Suite 916 J, The Children's Hospital of Philadelphia, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1177/0091270007304105DOI Listing
September 2007

A sensitive and selective liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of actinomycin-D and vincristine in children with cancer.

J Mass Spectrom 2007 Jun;42(6):761-70

Division of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/jms.1211DOI Listing
June 2007

Facilitating compound progression of antiretroviral agents via modeling and simulation.

J Neuroimmune Pharmacol 2007 Mar 17;2(1):58-71. Epub 2007 Jan 17.

Laboratory for Applied PK/PD, Clinical Pharmacology and Therapeutics Division, The Children's Hospital of Philadelphia, Abramson Research Center, Room 916H, 3516 Civic Center Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s11481-006-9061-zDOI Listing
March 2007

Model-based drug development applied to oncology.

Expert Opin Drug Discov 2007 Feb;2(2):185-209

Laboratory for Applied PK/PD, Clinical Pharmacology & Therapeutics Division, The Children's Hospital of Philadelphia, USA .

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http://dx.doi.org/10.1517/17460441.2.2.185DOI Listing
February 2007

Analysis and comparison of active constituents in commercial standardized silymarin extracts by liquid chromatography-electrospray ionization mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2007 Jan 30;845(1):95-103. Epub 2006 Aug 30.

Division of Clinical Pharmacology & Therapeutics, The Children's Hospital of Philadelphia, Abramson Research Center 916H, Philadelphia, PA 19104-4399, USA.

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http://dx.doi.org/10.1016/j.jchromb.2006.07.063DOI Listing
January 2007

Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry.

J Chromatogr A 2006 May 24;1116(1-2):57-68. Epub 2006 Apr 24.

Division of Clinical Pharmacology & Therapeutics, The Children's Hospital of Philadelphia, Abramson Research Center 916H, Philadelphia, PA 19104-4399, USA.

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http://dx.doi.org/10.1016/j.chroma.2006.03.053DOI Listing
May 2006

A liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of actinomycin-D and vincristine in children with cancer.

Cancer Chemother Pharmacol 2006 Apr 27;57(4):458-64. Epub 2005 Sep 27.

Division of Clinical Pharmacology and Therapeutics, Children's Hospital of Philadelphia, Abramson Research Center, Suite 916, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s00280-005-0065-9DOI Listing
April 2006

Drug utilization in the pediatric intensive care unit: monitoring prescribing trends and establishing prioritization of pharmacotherapeutic evaluation of critically ill children.

J Clin Pharmacol 2005 Nov;45(11):1305-12

Department of Pediatrics, Division of Clinical Pharmacology and Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1177/0091270005280966DOI Listing
November 2005

Modeling and simulation of adherence: approaches and applications in therapeutics.

AAPS J 2005 Oct 5;7(2):E390-407. Epub 2005 Oct 5.

Food and Drug Administration, Rockville, MD 20857, USA.

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http://link.springer.com/10.1208/aapsj070240
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http://dx.doi.org/10.1208/aapsj070240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750977PMC
October 2005

Population pharmacokinetic studies in pediatrics: issues in design and analysis.

AAPS J 2005 Oct 5;7(2):E475-87. Epub 2005 Oct 5.

Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.

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http://dx.doi.org/10.1208/aapsj070248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750985PMC
October 2005

Application and impact of population pharmacokinetics in the assessment of antiretroviral pharmacotherapy.

Clin Pharmacokinet 2005 ;44(6):591-625

Children's Hospital of Philadelphia and University of Pennsylvania, 19104, USA.

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http://link.springer.com/10.2165/00003088-200544060-00003
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August 2005

The effect of food on the pharmacokinetics of a dual angiotensin-converting enzyme/neutral endopeptidase inhibitor, M100240.

J Clin Pharmacol 2004 Dec;44(12):1379-84

Drug Metabolism and Pharmacokinetics, Aventis Pharmaceuticals, Inc, 1041 Route 202-206, PO Box 6800, Mail stop M303B, Bridgewater, NJ 08807-0800, USA.

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http://doi.wiley.com/10.1177/0091270004269557
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December 2004

Optimizing dose selection with modeling and simulation: application to the vasopeptidase inhibitor M100240.

J Clin Pharmacol 2004 Jun;44(6):621-31

Aventis Pharmaceuticals, 1041 Route 202-206, Bridgewater, NJ 08807, USA.

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http://doi.wiley.com/10.1177/0091270004265365
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June 2004

No clinically relevant CYP3A induction with the dual angiotensin-converting enzyme/neutral endopeptidase inhibitor, M100240.

J Clin Pharmacol 2004 Apr;44(4):379-87

Drug Metabolism and Pharmacokinetics, Aventis Pharmaceuticals, Inc., 1041 Route 202-206, P.O. Box 6800, Mailstop M303B, Bridgewater, NJ 08807-0800, USA.

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http://doi.wiley.com/10.1177/0091270004263948
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April 2004